Ian Blair, PhD

University of Pennsylvania
Molecular Profiling Core

Research in the Blair laboratory is focused on elucidating the role of oxidative stress in cancer and cardiovascular disease. This involves the determination of factors that control oxidative stress-mediated damage to proteins, peptides and DNA. We are also conducting metabolomics and lipidomics analyses using mass spectrometry-based methodology in order to discover new disease biomarkers. The utility of the resulting biomarkers for monitoring mitochondrial dysfunction, cardiovascular disease, and cancer is being evaluated. We are also examining how the biomarkers are modulated through smoking and the use of non-steroidal anti-inflammatory drugs and anti-oxidants.