Jeffrey Barrett, PhD

Children's Hospital of Philadelphia
Human Biology; Systems, Modeling and Computation

Dr. Barrett's expertise is in modeling and simulation approaches related to quantitative pharmacology, spanning from in vitro systems through the clinical description of disease progression. The value of this effort to PENTACON will be through the optimization of experimental designs via simulation approaches, PK/PD modeling to identify target exposures and effects in in vitro and animal models as well as healthy volunteers and patients and clinical trial simulation again to ensure design features that match expectations derived from complementary data and assumptions. The culmination of these efforts should also permit the generation of disease progression models that incorporates biochemical and clinical biomarkers with quality of life measures that describe the patient diversity as well as the underlying disease etiology over time.