Tim Hla, PhD

Weill Cornell Medical College
Mouse Models

Dr. Hla cloned the human COX-2 cDNA in 1992, demonstrated its post-transcriptional control by cytokines and glucocorticoids, and recently developed a mouse model for tissue specific deletion of HuR, the RNA binding protein that regulates COX-2 as well as other inflammatory response genes. He also showed that COX-2 signaling via nuclear receptors regulate thrombotic gene expression in endothelial cells, which may be involved in Coxib-induced side effects.