Tools and Systems



We present genome-wide functional interaction networks for 144 human tissues and cell types developed using a data-driven Bayesian methodology that integrates thousands of diverse experiments spanning tissue and disease states. Tissue-specific networks predict lineage-specific responses to perturbation, identify the changing functional roles of genes across tissues and illuminate relationships among diseases. We introduce NetWAS, which combines genes with nominally significant genome-wide association study (GWAS) P values and tissue-specific networks to identify disease-gene associations more accurately than GWAS alone. Our webserver, GIANT, provides an interface to human tissue networks through multi-gene queries, network visualization, analysis tools including NetWAS and downloadable networks. GIANT enables systematic exploration of the landscape of interacting genes that shape specialized cellular functions across more than a hundred human tissues and cell types. (

Curated Data Resource (


PENTACON curators compiled lists of human genes involved in the Arachidonic Acid Pathway (AAP) and related networks based on the expertise of PENTACON researchers, as well as curated information from external resources including KEGG, Reactome, and GO. The genes were ranked as "Gold Standard", "Likely" or "Predicted" to be involved in the Arachidonic Acid or related pathways according to available experimental evidence. Specific gene curation was then performed by PENTACON curators based on information available in UniProt, BRENDA, BindingDB and the literature. The manually curated information, including chemicals, tissue specificity and disease involvement, was captured using standardized ontology terms. (

AAP Pathway Viewer


We created an interactive, graphical figure of the Arachidonic Acid Pathway to place the information we curated in its cellular context. The pathway figure is organized into four distinct quadrants showing the different origins and fates of arachidonic acid in the human body. When clicked, the graphical elements of the diagram display additional information and linkouts for each protein and eicosanoid in the pathway and for over 60 NSAIDs affecting the COX1 and/or COX2 enzymes. (AAP Pathway Viewer)PTGS1

bii data repository (

An extensive, annotated bii repository of large-scale data sets relevant to the NSAID response, including data sets published by the PENTACON consortium and by others. (

Orthologs @CDR


PENTACON curators identified mouse, rat, fish, and yeast orthologs and analogs of human arachidonic acid pathway genes using P-POD version 4 (Heinicke et al 2007) and IMP (Wong et al 2012). Orthologs were based on P-POD's OrthoMCL analysis when possible or, when the human gene was not assigned to an OrthoMCL family, on P-POD's MultiParanoid analysis. Functional analogs were obtained from IMP using a cutoff of p < 0.05. Evidence codes document how the orthologs/analogs were selected and are included in the download file. These data can be viewed as web table or can be downloaded as tab-delimited files (Orthologs and Analogs file, the README, and the evidence code file).(