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» Arachidonic Acid Pathway v14
Arachidonic Acid Pathway v14
Posted on:
22 August 2016
By:
Sven
PTGS1 PTGS2 COX1 COX2
Arachidonic acid
all-
cis
-5,8,11,14-Eicosatetraenoic acid
= other eicosanoids
= 15(R)-HETE
15R
M
= metabolites
HETEs
DHETs
Epoxides
(EETs)
CyP450
Hepoxilins
and
Trioxilins
12(S)-HETE
G
P
X
’
s
12(S)-HpETE
12-Lipoxygenase (12-LO)
A
L
O
X
1
2
B
M
Lipoxins A4 & B4
(LXA
4
& LXB
4
)
5-LO
15(S)-HETE
G
P
X
’
s
15(S)-HpETE
15-Lipoxygenase
Leukotriene
transporters
Leukotriene
receptors
M
Leukotrienes
M
Leukotriene A4
(LTA
4
)
LOX5 regulators
5-Lipoxygenase (5-LO)
5-HETEs
acetylated COX2
15R
Thromboxane
A2 receptor
M
Thromboxane A2
(TxA
2
)
Prostaglandin
receptors
M
Prostaglandins
Prostacyclin
receptor
M
Prostacyclin
(PGI
2
)
Prostaglandin H2
(PGH
2
)
COX2 inhibitors
(
e
.
g
. celecoxib)
Non-selective NSAIDs
(
e
.
g
. aspirin,
ibuprofen, naproxen)
COX2
COX1
Central lipid and
phospholipid metabolism
diet
e
x
t
e
n
s
i
o
n
o
f
l
i
n
o
l
e
i
c
a
c
i
d
arachidonic acid
remodeling
a
d
d
i
t
i
o
n
o
f
C
o
A
c
l
e
a
v
a
g
e
o
f
p
h
o
s
p
h
o
l
i
p
i
d
s
