Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome
Title | Towards metabolic biomarkers of insulin resistance and type 2 diabetes: progress from the metabolome |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Roberts LD, Koulman A, Griffin JL |
Journal | Lancet Diabetes Endocrinol |
Volume | 2 |
Issue | 1 |
Pagination | 65-75 |
Date Published | 2014 Jan |
ISSN | 2213-8595 |
Keywords | Biomarkers, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Lipid Metabolism, Metabolomics, Prognosis, Risk Factors |
Abstract | The complex aetiology of type 2 diabetes makes effective screening, diagnosis and prognosis a substantial challenge for the physician. The rapidly developing area of metabolomics, which uses analytical techniques such as mass spectrometry and nuclear magnetic resonance, has emerged as a promising approach to identify biomarkers of diabetes and the insulin-resistant state that precedes overt pathology. Initial successes with metabolomic studies have indicated potential biomarkers for insulin resistance and for identifying people at risk of developing diabetes, with particular focus on aminoacids and lipid metabolism. These biomarkers will help to improve research and management of diabetes. In particular, several biomarkers identified could be used for early identification of diabetes risk. Furthermore, changes in selected biomarkers can indicate effectiveness of therapeutic interventions for type 2 diabetes and the metabolic syndrome. Indeed, there is much promise that branched-chain aminoacids might provide a screening biomarker for type 2 diabetes risk, allowing early dietary and exercise interventions to treat or even prevent the disease. |
DOI | 10.1016/S2213-8587(13)70143-8 |
Alternate Journal | Lancet Diabetes Endocrinol |
PubMed ID | 24622670 |
Grant List | Bb/H013539/2 / / Biotechnology and Biological Sciences Research Council / United Kingdom ES022186 / ES / NIEHS NIH HHS / United States MC_PC_13030 / / Medical Research Council / United Kingdom MC_UP_A090_1006 / / Medical Research Council / United Kingdom UD99999906 / / Medical Research Council / United Kingdom bb/I000933/I / / Biotechnology and Biological Sciences Research Council / United Kingdom / / British Heart Foundation / United Kingdom |