Curator Name REGULATOR UniProt ID REGULATOR NCBI Gene ID REGULATOR Gene Name REGULATOR Type REGULATOR Species Name REGULATOR Taxonomy ID REGULATOR UniProt Data Type REGULATOR UniProt Data Value REGULATOR UniProt Version Date REGULATOR UniProt Version REGULATOR Part of Complex REGULATOR Name of Complex BioGRID PPI Curation REGULATOR, ADDITIONAL UniProt ID(s) REGULATOR, ADDITIONAL NCBI Gene ID(s) REGULATOR, ADDITIONAL Gene Name(s) REGULATOR, ADDITIONAL Type REGULATOR, ADDITIONAL Species Name(s) REGULATOR, ADDITIONAL Taxonomy ID REGULATOR, ADDITIONAL UniProt Data Type REGULATOR, ADDITIONAL UniProt Data Value REGULATOR, ADDITIONAL UniProt Version Date REGULATOR, ADDITIONAL UniProt Version TARGET UniProt ID TARGET NCBI Gene ID TARGET Gene Name TARGET Type TARGET Species name TARGET Taxonomy ID TARGET UniProt Data Type TARGET UniProt Data Value TARGET UniProt Version Date TARGET UniProt Version Experiment Type Experiment Type ID Molecular Interactions Ontology Term Molcular Interactions Ontology ID GO Term GO ID Uberon Term Uberon ID BRENDA Tissue Ontology Term BRENDA Tissue Ontology ID Human Disease Ontology Term Human Disease Ontology ID ChEBI Chemical Term ChEBI Chemical ID Reviewed (Y/N) Use (Y/N) Source PENTACON Notes REGULATOR Gene Set REGULATOR, ADDITIONAL Gene Set TARGET Gene Set PENTACON Annotation No Jodi P42226 6778 STAT6 protein Homo sapiens 9606 P16050 246 ALOX15 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 BEAS-2B cell BTO:0002923 y y PMID:10657944 IL-4 induced formation of DNA-protein complex AAP 4000000001 Jodi P42226 6778 STAT6 protein Homo sapiens 9606 P16050 246 ALOX15 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 BEAS-2B cell BTO:0002923 y y PMID:10657944 regulation is induced by IL-4 AAP 4000000002 Jodi Q92908 2627 GATA6 protein Homo sapiens 9606 P16050 246 ALOX15 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 CACO-2 cell BTO:0000195 colon adenocarcinoma DOID:234 y y PMID:10675566 AAP 4000000003 Katie P15336 1386 ATF2 protein Homo sapiens 9606 yes AP1 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 mammary epithelial cell line BTO:0002768 paclitaxel CHEBI:45863 y y PMID:10809726 AAP 4000000004 Katie P01100 2353 FOS protein Homo sapiens 9606 yes AP1 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 mammary epithelial cell line BTO:0002768 paclitaxel CHEBI:45863 y y PMID:10809726 AAP 4000000005 Katie P05412 3725 JUN protein Homo sapiens 9606 yes AP1 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 mammary epithelial cell line BTO:0002768 paclitaxel CHEBI:45863 y y PMID:10809726 AAP 4000000006 Katie P05412 3725 JUN protein Homo sapiens 9606 yes AP1 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 mammary epithelial cell line BTO:0002768 paclitaxel CHEBI:45863 y y PMID:10809726 AAP 4000000007 Katie P08047 6667 SP1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 umbilical vein endothelium UBERON:0007777 umbilical vein endothelial cell line BTO:0001520 y y PMID:10825178 Assessed COX-2 induction by hypoxia AAP 4000000008 Katie P08047 6667 SP1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 umbilical vein endothelium UBERON:0007777 umbilical vein endothelial cell line BTO:0001520 y y PMID:10825178 Assessed COX-2 induction by hypoxia AAP 4000000009 Katie Q02447 6670 SP3 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 umbilical vein endothelium UBERON:0007777 umbilical vein endothelial cell line BTO:0001520 y y PMID:10825178 Assessed COX-2 induction by hypoxia AAP 4000000010 Katie Q02447 6670 SP3 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 umbilical vein endothelium UBERON:0007777 umbilical vein endothelial cell line BTO:0001520 y y PMID:10825178 Assessed COX-2 induction by hypoxia AAP 4000000011 Jodi P08047 6667 SP1 protein Homo sapiens 9606 Q16873 4056 LTC4S gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 y y PMID:10919991 nuclear extract; supershifted bands were observed in the presence of anti-Sp1 antibody AAP 4000000012 Jodi Q02447 6670 SP3 protein Homo sapiens 9606 Q16873 4056 LTC4S gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 y y PMID:10919991 nuclear extract; supershifted bands were observed in the presence of anti-Sp3 antibody AAP 4000000013 Jodi P08047 6667 SP1 protein Homo sapiens 9606 Q16873 4056 LTC4S gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 THP-1 cell BTO:0001370 acute monocytic leukemia DOID:8864 y y PMID:10919991 nuclear extract; supershifted bands were observed in the presence of anti-Sp1 antibody AAP 4000000014 Jodi Q02447 6670 SP3 protein Homo sapiens 9606 Q16873 4056 LTC4S gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 THP-1 cell BTO:0001370 acute monocytic leukemia DOID:8864 y y PMID:10919991 nuclear extract; supershifted bands were observed in the presence of anti-Sp3 antibody AAP 4000000015 Jodi P08047 6667 SP1 protein Homo sapiens 9606 Q16873 4056 LTC4S gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:10919991 purified SP1 used AAP 4000000016 Chandra Q16236 4780 NFE2L2 protein Homo sapiens 9606 yes P37238 19016 Pparg protein Mus musculus 10090 P49430 24886 Tbxas1 gene Rattus norvegicus 10116 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 NR-8383 cell BTO:0002907 15-deoxy-Delta(12,14)-prostaglandin J2 CHEBI:34159 y y PMID:10930400 PPARG appears to bind NRF2 and block interaction with the promoter, resulting in transcriptional suppression; addition of PGJ2 further suppresses transcription 4000000017 Chandra Q16236 4780 NFE2L2 protein Homo sapiens 9606 yes P37238 19016 Pparg protein Mus musculus 10090 P49430 24886 Tbxas1 gene Rattus norvegicus 10116 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 NR-8383 cell BTO:0002907 y y PMID:10930400 PPARG appears to bind NRF2 and block interaction with the promoter, resulting in transcriptional suppression 4000000018 Chandra Q16236 4780 NFE2L2 protein Homo sapiens 9606 yes O88275 25664 Pparg protein Rattus norvegicus 10116 P49430 24886 Tbxas1 gene Rattus norvegicus 10116 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 NR-8383 cell BTO:0002907 y y PMID:10930400 PPARG appears to bind NRF2 and blocks NRF2 interaction with the promoter, resulting in transcriptional repression 4000000019 Chandra Q16236 4780 NFE2L2 protein Homo sapiens 9606 P49430 24886 Tbxas1 gene Rattus norvegicus 10116 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 NR-8383 cell BTO:0002907 y y PMID:10930400 4000000020 Chandra P37238 19016 Pparg protein Mus musculus 10090 P49430 24886 Tbxas1 gene Rattus norvegicus 10116 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 NR-8383 cell BTO:0002907 y y PMID:10930400 4000000021 Jodi P14859 5451 POU2F1 protein Homo sapiens 9606 O60760 27306 HPGDS gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 Dami cell BTO:0001550 y y PMID:10998423 AAP 4000000022 Jodi P05549 7020 TFAP2A protein Homo sapiens 9606 O60760 27306 HPGDS gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 Dami cell BTO:0001550 y y PMID:10998423 protein not directly shown to bind DNA AAP 4000000023 Jodi P05549 7020 TFAP2A protein Homo sapiens 9606 O60760 27306 HPGDS gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 regulation of gene expression GO:0010468 Hep-G2 cell BTO:0000599 hepatocellular carcinoma DOID:684 y y PMID:10998423 AAP 4000000024 Jodi P13010 7520 XRCC5 protein Homo sapiens 9606 P16050 246 ALOX15 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 A-549 cell BTO:0000018 bronchiolo-alveolar adenocarcinoma DOID:4926 y y PMID:11196700 AAP 4000000025 Jodi P12956 2547 XRCC6 protein Homo sapiens 9606 P16050 246 ALOX15 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 A-549 cell BTO:0000018 bronchiolo-alveolar adenocarcinoma DOID:4926 y y PMID:11196700 AAP 4000000026 Katie P37231 5468 PPARG protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 epithelial cell line BTO:0001120 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:11278336 PPAR-g activation inhibits PMA-mediated induction of COX-2 expression by blocking induction of c-Jun and binding CBP so that it can't interact with AP-1 BP AAP 4000000027 Katie P15336 1386 ATF2 protein Homo sapiens 9606 yes AP1 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 mammary epithelial cell line BTO:0002768 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:11278336 AAP 4000000028 Katie Q92793 1387 CREBBP protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 mammary epithelial cell line BTO:0002768 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:11278336 AAP 4000000029 Katie P01100 2353 FOS protein Homo sapiens 9606 yes AP1 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 mammary epithelial cell line BTO:0002768 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:11278336 AAP 4000000030 Katie P05412 3725 JUN protein Homo sapiens 9606 yes AP1 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 mammary epithelial cell line BTO:0002768 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:11278336 AAP 4000000031 Katie P05412 3725 JUN protein Homo sapiens 9606 yes AP1 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 mammary epithelial cell line BTO:0002768 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:11278336 AAP 4000000032 Katie P37231 5468 PPARG protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 mammary epithelial cell line BTO:0002768 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:11278336 PPAR-g activation inhibits PMA-mediated induction of COX-2 expression by blocking induction of c-Jun and binding CBP so that it can't interact with AP-1 BP AAP 4000000033 Chandra P17676 1051 CEBPB protein Homo sapiens 9606 Q09472 2033 EP300 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 protein expression level evidence ECO:0000046 negative regulation of gene expression GO:0010629 foreskin fibroblast cell line BTO:0002245 phorbol ester CHEBI:37532 y y PMID:11741938 PMA-induced activation of COX2 protein levels by EP300 was blocked by co-transfection with CEBPB AAP 4000000034 Chandra P17676 1051 CEBPB protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 nucleic acid binding evidence ECO:0000136 direct interaction MI:0407 foreskin fibroblast cell line BTO:0002245 phorbol ester CHEBI:37532 y y PMID:11741938 Protein bound to biotinylated DNA probes was pulled down with streptavidin-coated beads AAP 4000000035 Chandra P17676 1051 CEBPB protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 nucleic acid binding evidence ECO:0000136 direct interaction MI:0407 foreskin fibroblast cell line BTO:0002245 y y PMID:11741938 Protein bound to biotinylated DNA probes was pulled down with streptavidin-coated beads AAP 4000000036 Chandra P17676 1051 CEBPB protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 foreskin fibroblast cell line BTO:0002245 phorbol ester CHEBI:37532 y y PMID:11741938 AAP 4000000037 Chandra P49716 1052 CEBPD protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 nucleic acid binding evidence ECO:0000136 direct interaction MI:0407 foreskin fibroblast cell line BTO:0002245 phorbol ester CHEBI:37532 y y PMID:11741938 Protein bound to biotinylated DNA probes was pulled down with streptavidin-coated beads AAP 4000000038 Chandra P49716 1052 CEBPD protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 nucleic acid binding evidence ECO:0000136 direct interaction MI:0407 foreskin fibroblast cell line BTO:0002245 y y PMID:11741938 Protein bound to biotinylated DNA probes was pulled down with streptavidin-coated beads AAP 4000000039 Chandra Q09472 2033 EP300 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 protein expression level evidence ECO:0000046 positive regulation of gene expression GO:0010628 foreskin fibroblast cell line BTO:0002245 phorbol ester CHEBI:37532 y y PMID:11741938 AAP 4000000040 Chandra P37238 19016 Pparg isoform 1 protein Mus musculus 10090 Comment/alternative products/isoform P37238-2 7/24/2013 144 P34978 24816 Tbxa2r gene Rattus norvegicus 10116 transcriptional activation assay ECO:0000170 negative regulation of gene expression GO:0010629 vascular smooth muscle cell BTO:0004578 y y PMID:11777901 rat TBXA2R has only 1 form; expression of PPARG isoform 1 represses expression of TBXA2R promoter with out without ligands 4000000041 Chandra P37238 19016 Pparg isoform 1 protein Mus musculus 10090 Comment/alternative products/isoform P37238-2 7/24/2013 144 P34978 24816 Tbxa2r gene Rattus norvegicus 10116 transcriptional activation assay ECO:0000170 negative regulation of gene expression GO:0010629 vascular smooth muscle cell BTO:0004578 15-deoxy-Delta(12,14)-prostaglandin J2 CHEBI:34159 y y PMID:11777901 rat TBXA2R has only 1 form; expression of PPARG isoform 1 represses expression of TBXA2R promoter with out without ligands 4000000042 Chandra P37238 19016 Pparg isoform 1 protein Mus musculus 10090 Comment/alternative products/isoform P37238-2 7/24/2013 144 P34978 24816 Tbxa2r gene Rattus norvegicus 10116 transcriptional activation assay ECO:0000170 negative regulation of gene expression GO:0010629 vascular smooth muscle cell BTO:0004578 troglitazone CHEBI:9753 y y PMID:11777901 rat TBXA2R has only 1 form; expression of PPARG isoform 1 represses expression of TBXA2R promoter with out without ligands 4000000043 Chandra Q01714 24790 Sp1 protein Rattus norvegicus 10116 yes Pparg/Sp1 P37238-2 19016 Pparg isoform 1 protein Mus musculus 10090 Comment/alternative products/isoform P37238-2 7/24/2013 132 P34978 24816 Tbxa2r gene Rattus norvegicus 10116 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 vascular smooth muscle cell BTO:0004578 y y PMID:11777901 Co-expression of Pparg represses the induced transcription by Sp1 at Tbxa2r promoter 4000000044 Chandra Q01714 24790 Sp1 protein Rattus norvegicus 10116 P34978 24816 Tbxa2r gene Rattus norvegicus 10116 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 vascular smooth muscle cell BTO:0004578 y y PMID:11777901 EMSA with endogenous TFs in nuclear extract, supershifts to id which Sp; found Sp1 exclusively 4000000045 Chandra O89090 20683 Sp1 isoform 1 protein Mus musculus 10090 Comment/alternative products/isoform O89090-1 7/24/2013 121 P37238-2 19016 Pparg isoform 1 protein Mus musculus 10090 Comment/alternative products/isoform P37238-2 7/24/2013 132 P34978 24816 Tbxa2r gene Rattus norvegicus 10116 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 vascular smooth muscle cell BTO:0004578 y y PMID:11777901 Co-overexpression of Sp1 and PPARG represses expression 4000000046 Chandra O89090 20683 Sp1 isoform 1 protein Mus musculus 10090 Comment/alternative products/isoform O89090-1 7/24/2013 121 P34978 24816 Tbxa2r gene Rattus norvegicus 10116 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 vascular smooth muscle cell BTO:0004578 y y PMID:11777901 Overexpression of Sp1 induces expression 4000000047 Chandra O89090 20683 Sp1 isoform 1 protein Mus musculus 10090 Comment/alternative products/isoform O89090-1 7/24/2013 121 P34978 24816 Tbxa2r gene Rattus norvegicus 10116 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:11777901 EMSA with in vitro transcription/translation (Rabbit Reticulocyte Lysate) of TF 4000000048 Katie P15336 1386 ATF2 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 myofibroblast cell line BTO:0004166 y y PMID:11880271 IL-1 used to induce COX-2 expression, detected binding only for Jun/ATF and cEBP-beta AAP 4000000049 Katie P17676 1051 CEBPB protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 myofibroblast cell line BTO:0004166 y y PMID:11880271 IL-1 used to induce COX-2 expression, detected binding only for Jun/ATF and cEBP-beta AAP 4000000050 Katie P05412 3725 JUN protein Homo sapiens 9606 yes AP1 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 myofibroblast cell line BTO:0004166 y y PMID:11880271 IL-1 used to induce COX-2 expression, detected binding only for Jun/ATF and cEBP-beta AAP 4000000051 Katie P19838 4790 NFKB1 protein Homo sapiens 9606 yes NFkB P19838 4790 NFKB1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 myofibroblast cell line BTO:0004166 y y PMID:11880271 IL-1 used to induce COX-2 expression, detected both p65/p50 and p50/p50 dimers, used NFkB inhibitors to confirm role in COX-2 induction AAP 4000000052 Katie P19838 4790 NFKB1 protein Homo sapiens 9606 yes NFkB Q04206 5970 RELA protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 myofibroblast cell line BTO:0004166 y y PMID:11880271 IL-1 used to induce COX-2 expression, detected both p65/p50 and p50/p50 dimers, used NFkB inhibitors to confirm role in COX-2 induction AAP 4000000053 Chandra Q16621 4778 NFE2 protein Homo sapiens 9606 yes NF-E2 P24557 6916 TBXAS1 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL cell BTO:0000565 leukemia DOID:1240 y y PMID:11956185 AAP 4000000054 Chandra Q16621 4778 NFE2 protein Homo sapiens 9606 yes NF-E2 P24557 6916 TBXAS1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HEL cell BTO:0000565 leukemia DOID:1240 y y PMID:11956185 AAP 4000000055 Chandra Q16621 4778 NFE2 protein Homo sapiens 9606 yes NF-E2 P24557 6916 TBXAS1 gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 HL-60 cell BTO:0000738 acute myeloid leukemia DOID:9119 y y PMID:11956185 AAP 4000000056 Katie P37231 5468 PPARG protein Homo sapiens 9606 no P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 respiratory system smooth muscle UBERON:0004225 respiratory smooth muscle BTO:0001660 y y PMID:12517972 PPAR-g stimulated COX-2 expression by binding to PPRE in COX-2 promoter; HASM (Homo sapiens airway smooth muscle) cells, primary derived BP AAP 4000000057 Jodi P49715 1050 CEBPA protein Homo sapiens 9606 P20292 241 ALOX5AP gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 THP-1 cell BTO:0001370 acute monocytic leukemia DOID:8864 y y PMID:12571239 binds proximal and distal C/EBP consensus sites; TNFalpha induces a time-dependent increase in binding AAP 4000000058 Jodi P49715 1050 CEBPA protein Homo sapiens 9606 P20292 241 ALOX5AP gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 THP-1 cell BTO:0001370 acute monocytic leukemia DOID:8864 y y PMID:12571239 AAP 4000000059 Jodi P17676 1051 CEBPB protein Homo sapiens 9606 P20292 241 ALOX5AP gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 THP-1 cell BTO:0001370 acute monocytic leukemia DOID:8864 y y PMID:12571239 AAP 4000000060 Jodi P49716 1052 CEBPD protein Homo sapiens 9606 P20292 241 ALOX5AP gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 THP-1 cell BTO:0001370 acute monocytic leukemia DOID:8864 y y PMID:12571239 binds proximal and distal C/EBP consensus sites; TNFalpha induces a time-dependent increase in binding to the proximal site and new binding to the distal site AAP 4000000061 Jodi P49716 1052 CEBPD protein Homo sapiens 9606 P20292 241 ALOX5AP gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 THP-1 cell BTO:0001370 acute monocytic leukemia DOID:8864 y y PMID:12571239 AAP 4000000062 Jodi Q15744 1053 CEBPE protein Homo sapiens 9606 P20292 241 ALOX5AP gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 THP-1 cell BTO:0001370 acute monocytic leukemia DOID:8864 y y PMID:12571239 binds proximal and distal C/EBP consensus sites; TNFalpha induces a time-dependent increase in binding AAP 4000000063 Chandra P08047 6667 SP1 protein Homo sapiens 9606 no O14684 9536 PTGES gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 regulation of gene expression GO:0010468 A-549 cell BTO:0000018 bronchiolo-alveolar adenocarcinoma DOID:4926 y y PMID:12818425 AAP 4000000064 Chandra Q02447 6670 SP3 protein Homo sapiens 9606 no O14684 9536 PTGES gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 regulation of gene expression GO:0010468 A-549 cell BTO:0000018 bronchiolo-alveolar adenocarcinoma DOID:4926 y y PMID:12818425 AAP 4000000065 Chandra P08047 6667 SP1 protein Homo sapiens 9606 no O14684 9536 PTGES gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 y y PMID:12818425 AAP 4000000066 Chandra Q02447 6670 SP3 protein Homo sapiens 9606 no O14684 9536 PTGES gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 y y PMID:12818425 AAP 4000000067 Chandra P08047 6667 SP1 protein Homo sapiens 9606 no Q9H7Z7 80142 PTGES2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 Hep-G2 cell BTO:0000599 hepatocellular carcinoma DOID:684 y y PMID:12818425 AAP 4000000068 Chandra P08047 6667 SP1 protein Homo sapiens 9606 no Q9H7Z7 80142 PTGES2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 regulation of gene expression GO:0010468 Hep-G2 cell BTO:0000599 hepatocellular carcinoma DOID:684 y y PMID:12818425 AAP 4000000069 Chandra Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB O14684 9536 PTGES gene Homo sapiens 9606 transcriptional activation assay ECO:0000170 positive regulation of gene expression GO:0010628 A-549 cell BTO:0000018 bronchiolo-alveolar adenocarcinoma DOID:4926 y y PMID:12860389 IL1B induced expression of mRNA and PGE2 release is blocked by dominant negative IkB AAP 4000000070 Chandra Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P35354 5743 PTGS2 gene Homo sapiens 9606 transcriptional activation assay ECO:0000170 positive regulation of gene expression GO:0010628 A-549 cell BTO:0000018 bronchiolo-alveolar adenocarcinoma DOID:4926 y y PMID:12860389 IL1B induced expression of mRNA and PGE2 release is blocked by dominant negative IkB AAP 4000000071 Jodi Q00175 18667 Pgr protein Mus musculus 10090 Q62053 19217 Ptger2 gene Mus musculus 10090 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 y y PMID:12940822 nuclear extracts from HeLa cells transfected with Pgr subtype B; some of the resulting bands were super-shifted with anti-Pgr antibody 4000000072 Jodi Q00175 18667 Pgr protein Mus musculus 10090 Q62053 19217 Ptger2 gene Mus musculus 10090 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 y y PMID:12940822 transient transfection of HeLa cells 4000000073 Jodi Q00175 18667 Pgr protein Mus musculus 10090 Q62053 19217 Ptger2 gene Mus musculus 10090 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 progesterone CHEBI:17026 y y PMID:12940822 transient transfection of HeLa cells; Pgr isoform B gives much greater induction in the presence of progesterone than Pgr isoform A 4000000074 Jodi P08047 6667 SP1 protein Homo sapiens 9606 Q62053 19217 Ptger2 gene Mus musculus 10090 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 y y PMID:12940822 nuclear extracts from HeLa cells; supershift analysis with anti-Sp1 4000000075 Jodi Q02447 6670 SP3 protein Homo sapiens 9606 Q62053 19217 Ptger2 gene Mus musculus 10090 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 y y PMID:12940822 nuclear extracts from HeLa cells; supershift analysis with anti-Sp3 4000000076 Jodi P06401 5241 PGR protein Homo sapiens 9606 Q62053 19217 Ptger2 gene Mus musculus 10090 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 T-47D cell BTO:0001248 breast carcinoma DOID:3459 y y PMID:12940822 nuclear extracts of T-47D cells used; one of the resulting bands was super-shifted with antibody against Pgr 4000000077 Katie P16220 1385 CREB1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 gastric adenocarcinoma cell line BTO:0002380 gastric adenocarcinoma DOID:3717 y y PMID:14531897 Investigated COX-2 induction following H. pylori infection AAP 4000000078 Katie P16220 1385 CREB1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 gastric adenocarcinoma cell line BTO:0002380 gastric adenocarcinoma DOID:3717 y y PMID:14531897 Investigated COX-2 induction following H. pylori infection AAP 4000000079 Katie P22415 7391 USF1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 gastric adenocarcinoma cell line BTO:0002380 gastric adenocarcinoma DOID:3717 y y PMID:14531897 Investigated COX-2 induction following H. pylori infection AAP 4000000080 Katie P22415 7391 USF1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 gastric adenocarcinoma cell line BTO:0002380 gastric adenocarcinoma DOID:3717 y y PMID:14531897 Investigated COX-2 induction following H. pylori infection AAP 4000000081 Katie Q15853 7392 USF2 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 gastric adenocarcinoma cell line BTO:0002380 gastric adenocarcinoma DOID:3717 y y PMID:14531897 Investigated COX-2 induction following H. pylori infection AAP 4000000082 Katie Q15853 7392 USF2 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 gastric adenocarcinoma cell line BTO:0002380 gastric adenocarcinoma DOID:3717 y y PMID:14531897 Investigated COX-2 induction following H. pylori infection AAP 4000000083 Chandra Q60795 18024 Nfe2l2 protein Mus musculus 10090 yes p300/CBP Q09472 2033 EP300 protein Homo sapiens 9606 P24557 6916 TBXAS1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 A-549 cell BTO:0000018 bronchiolo-alveolar adenocarcinoma DOID:4926 y y PMID:14565864 p300 further induces NRF2-stimulated expression of TBXAS1 and this requires the NRF2 binding site of the promoter. No experimental evidence for p300-NRF2 protein-protein interaction AAP 4000000084 Chandra Q16236 4780 NFE2L2 protein Homo sapiens 9606 P24557 6916 TBXAS1 gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 A-549 cell BTO:0000018 bronchiolo-alveolar adenocarcinoma DOID:4926 y y PMID:14565864 AAP 4000000085 Chandra Q60795 18024 Nfe2l2 protein Mus musculus 10090 P24557 6916 TBXAS1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 A-549 cell BTO:0000018 bronchiolo-alveolar adenocarcinoma DOID:4926 y y PMID:14565864 AAP 4000000086 Chandra Q60795 18024 Nfe2l2 protein Mus musculus 10090 P24557 6916 TBXAS1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 lung UBERON:0002048 WI-38 cell BTO:0000458 y y PMID:14565864 AAP 4000000087 Chandra P04637 7157 TP53 protein Homo sapiens 9606 no P24557 6916 TBXAS1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 glioblastoma cell line BTO:0001530 glioblastoma DOID:3068 y y PMID:14586398 suppression of basal TBXAS1 expression by co-transfection with p53 AAP 4000000088 Chandra P14921 2113 ETS1 protein Homo sapiens 9606 yes P04637 7157 TP53 protein Homo sapiens 9606 P24557 6916 TBXAS1 gene Homo sapiens 9606 RNA protection assay evidence ECO:0000110 negative regulation of gene expression GO:0010629 LN-308 cell BTO:0004457 glioblastoma DOID:3068 y y PMID:14586398 induction of TBXAS1 by ETS1 is blocked (and there is further repression) by also expressing p53 AAP 4000000089 Chandra P14921 2113 ETS1 protein Homo sapiens 9606 no P24557 6916 TBXAS1 gene Homo sapiens 9606 RNA protection assay evidence ECO:0000110 positive regulation of gene expression GO:0010628 LN-308 cell BTO:0004457 glioblastoma DOID:3068 y y PMID:14586398 AAP 4000000090 Chandra P04637 7157 TP53 protein Homo sapiens 9606 no P24557 6916 TBXAS1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 NCI-H1299 cell BTO:0002552 non-small cell lung carcinoma DOID:3908 y y PMID:14586398 suppression of basal TBXAS1 expression by co-transfection with p53 AAP 4000000091 Chandra P14921 2113 ETS1 protein Homo sapiens 9606 no P24557 6916 TBXAS1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 SAOS-2 cell BTO:0000971 bone osteosarcoma DOID:3376 y y PMID:14586398 AAP 4000000092 Chandra P04637 7157 TP53 protein Homo sapiens 9606 yes P14921 2113 ETS1 protein Homo sapiens 9606 P24557 6916 TBXAS1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 SAOS-2 cell BTO:0000971 bone osteosarcoma DOID:3376 Y Y PMID:14586398 ETS1-stimulated expression of TBXAS1 in a luciferase assay is blocked by expressing TP53; this p53-mediated repression requires the C-terminus of p53, the portion of p53 required to interact with ETS1 suggesting a direct interaction at the promoter AAP 4000000093 Chandra P04637 7157 TP53 protein Homo sapiens 9606 no P24557 6916 TBXAS1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 SAOS-2 cell BTO:0000971 bone osteosarcoma DOID:3376 y y PMID:14586398 suppression of basal TBXAS1 expression by co-transfection with p53 AAP 4000000094 Chandra P14921 2113 ETS1 protein Homo sapiens 9606 no P24557 6916 TBXAS1 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 SNB-19 cell BTO:0003761 glioblastoma DOID:3068 y y PMID:14586398 AAP 4000000095 Chandra P14921 2113 ETS1 protein Homo sapiens 9606 no P24557 6916 TBXAS1 gene Homo sapiens 9606 RNA protection assay evidence ECO:0000110 positive regulation of gene expression GO:0010628 SNB-19 cell BTO:0003761 glioblastoma DOID:3068 y y PMID:14586398 AAP 4000000096 Chandra P04637 7157 TP53 protein Homo sapiens 9606 no P24557 6916 TBXAS1 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:14586398 recombinant p53, not from extracts, binding requires concensus sites in promoter AAP 4000000097 Katie Q09472 2033 EP300 protein Homo sapiens 9606 Q92831 8850 KAT2B protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 foreskin fibroblast cell line BTO:0002245 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:14630807 Also used a streptavidin bead pulldown assay to demonstrate DNA binding AAP 4000000098 Katie Q09472 2033 EP300 protein Homo sapiens 9606 Q92831 8850 KAT2B protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 foreskin fibroblast cell line BTO:0002245 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:14630807 AAP 4000000099 Katie P17676 1051 CEBPB protein Homo sapiens 9606 no P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 respiratory system smooth muscle UBERON:0004225 respiratory smooth muscle BTO:0001660 y y PMID:14645533 Involved in COX-2 induction by IL-1b; HASM (Homo sapiens airway smooth muscle) cells, primary derived AAP 4000000100 Katie P17676 1051 CEBPB protein Homo sapiens 9606 no P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 respiratory system smooth muscle UBERON:0004225 respiratory smooth muscle BTO:0001660 y y PMID:14645533 Involved in COX-2 induction by IL-1b; HASM (Homo sapiens airway smooth muscle) cells, primary derived AAP 4000000101 Katie P17676 1051 CEBPB protein Homo sapiens 9606 no P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 respiratory system smooth muscle UBERON:0004225 respiratory smooth muscle BTO:0001660 y y PMID:14645533 Involved in COX-2 induction by IL-1b; HASM (Homo sapiens airway smooth muscle) cells, primary derived AAP 4000000102 Katie P16220 1385 CREB1 protein Homo sapiens 9606 no P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 respiratory system smooth muscle UBERON:0004225 respiratory smooth muscle BTO:0001660 y y PMID:14645533 Involved in COX-2 induction by bradykinin and IL-1b; HASM (Homo sapiens airway smooth muscle) cells, primary derived AAP 4000000103 Katie P16220 1385 CREB1 protein Homo sapiens 9606 no P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 respiratory system smooth muscle UBERON:0004225 respiratory smooth muscle BTO:0001660 y y PMID:14645533 Involved in COX-2 induction by bradykinin and IL-1b; HASM (Homo sapiens airway smooth muscle) cells, primary derived AAP 4000000104 Katie P16220 1385 CREB1 protein Homo sapiens 9606 no P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 respiratory system smooth muscle UBERON:0004225 respiratory smooth muscle BTO:0001660 y y PMID:14645533 Involved in COX-2 induction by bradykinin and IL-1b; HASM (Homo sapiens airway smooth muscle) cells, primary derived AAP 4000000105 Katie Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 respiratory system smooth muscle UBERON:0004225 respiratory smooth muscle BTO:0001660 y y PMID:14645533 Involved in COX-2 induction by IL-1b; HASM (Homo sapiens airway smooth muscle) cells, primary derived AAP 4000000106 Katie Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 respiratory system smooth muscle UBERON:0004225 respiratory smooth muscle BTO:0001660 y y PMID:14645533 Involved in COX-2 induction by IL-1b; HASM (Homo sapiens airway smooth muscle) cells, primary derived AAP 4000000107 Katie Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 respiratory system smooth muscle UBERON:0004225 respiratory smooth muscle BTO:0001660 y y PMID:14645533 Involved in COX-2 induction by IL-1b; HASM (Homo sapiens airway smooth muscle) cells, primary derived AAP 4000000108 Jodi P05412 3725 JUN protein Homo sapiens 9606 P19440 2678 GGT1 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:14684160 subtype B (transcript variant 1); addition of c-Jun antibody resulted in super-shifted band AAP 4000000109 Jodi P05412 3725 JUN protein Homo sapiens 9606 P19440 2678 GGT1 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 Hep-G2 cell BTO:0000599 hepatocellular carcinoma DOID:684 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:14684160 subtype B (transcript variant 1); addition of c-Jun antibody resulted in super-shifted band AAP 4000000110 Chandra P18146 1958 EGR1 protein Homo sapiens 9606 no Q9H7Z7 80142 PTGES2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HCA-7 cell BTO:0003031 colon adenocarcinoma DOID:234 TNF-alpha y y PMID:14722058 AAP 4000000111 Chandra P18146 1958 EGR1 protein Homo sapiens 9606 no Q9H7Z7 80142 PTGES2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HCA-7 cell BTO:0003031 colon adenocarcinoma DOID:234 TNF-alpha y y PMID:14722058 AAP 4000000112 Chandra P18146 1958 EGR1 protein Homo sapiens 9606 no Q9H7Z7 80142 PTGES2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 intestinal mucosa UBERON:0001242 ulcerative colitis disease specific cell type BTO:0004526 ulcerative colitis DOID:8577 y y PMID:14722058 inflamed mucosal tissue AAP 4000000113 Chandra P18146 1958 EGR1 protein Homo sapiens 9606 no Q9H7Z7 80142 PTGES2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 intestinal mucosa UBERON:0001242 Crohn's disease DOID:8778 y y PMID:14722058 inflamed mucosal tissue AAP 4000000114 Katie P43268 2118 ETV4 protein Homo sapiens 9606 Q09472 2033 EP300 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 colonic cancer cell line BTO:0000797 colon carcinoma DOID:1520 Y Y PMID:14976201 Used transfected RKO cells for reporter assays, investigated mechanism of NO-mediated induction of COX-2, PEA3 stimulated COX-2 expression alone and with co-activator p300 AAP 4000000115 Katie Q92793 1387 CREBBP protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 THP-1 cell BTO:0001370 diabetes mellitus DOID:9351 glucose CHEBI:17234 y y PMID:14976218 Used high glucose to induce COX-2, also investigated effects of histone modifications AAP 4000000116 Katie Q92831 8850 KAT2B protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 THP-1 cell BTO:0001370 diabetes mellitus DOID:9351 glucose CHEBI:17234 y y PMID:14976218 Used high glucose to induce COX-2, also investigated effects of histone modifications AAP 4000000117 Katie P19838 4790 NFKB1 protein Homo sapiens 9606 yes NFkB P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 THP-1 cell BTO:0001370 diabetes mellitus DOID:9351 glucose CHEBI:17234 y y PMID:14976218 Used high glucose to induce COX-2, also investigated effects of histone modifications AAP 4000000118 Katie Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 THP-1 cell BTO:0001370 diabetes mellitus DOID:9351 glucose CHEBI:17234 y y PMID:14976218 Used high glucose to induce COX-2, also investigated effects of histone modifications AAP 4000000119 Katie P16220 1385 CREB1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 THP-1 cell BTO:0001370 diabetes mellitus DOID:9351 glucose CHEBI:17234 y y PMID:14988266 Used monocyte cell line stimulated with high glucose and monocytes from diabetes patients to measure COX-2 levels, reporter assays done in cell line, also found NFkB was involved, but did not identify subunits AAP 4000000120 Jodi P08047 6667 SP1 protein Homo sapiens 9606 O15296 247 ALOX15B gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 PPC-1 cell BTO:0001062 y y PMID:15247906 AAP 4000000121 Jodi Q02447 6670 SP3 protein Homo sapiens 9606 O15296 247 ALOX15B gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 PPC-1 cell BTO:0001062 y y PMID:15247906 AAP 4000000122 Jodi P08047 6667 SP1 protein Homo sapiens 9606 O15296 247 ALOX15B gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 prostate cancer cell line BTO:0001033 prostate cancer DOID:10283 y y PMID:15247906 AAP 4000000123 Jodi Q02447 6670 SP3 protein Homo sapiens 9606 O15296 247 ALOX15B gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 prostate cancer cell line BTO:0001033 prostate cancer DOID:10283 y y PMID:15247906 AAP 4000000124 Jodi Q02447 6670 SP3 protein Homo sapiens 9606 O15296 247 ALOX15B gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 prostate epithelium UBERON:0000428 prostate gland epithelium BTO:0002397 y y PMID:15247906 NHP cells (normal human prostate epithelium) AAP 4000000125 Jodi P08047 6667 SP1 protein Homo sapiens 9606 O15296 247 ALOX15B gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 y y PMID:15247906 Drosophila SL2 cotransfection system AAP 4000000126 Jodi I6L9I6 17342 Mitf protein Mus musculus 10090 Q9JHF7 54486 Hpgds gene Mus musculus 10090 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 BMMC cell BTO:0003620 y y PMID:15375155 4000000127 Jodi I6L9I6 17342 Mitf protein Mus musculus 10090 Q9JHF7 54486 Hpgds gene Mus musculus 10090 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:15375155 4000000128 Jodi P19838 4790 NFKB1 protein Homo sapiens 9606 P20292 241 ALOX5AP gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 THP-1 cell BTO:0001370 acute monocytic leukemia DOID:8864 lipopolysaccharide CHEBI:16412 y y PMID:15625306 LPS induces p50 binding to the NFkB site in the proximal FLAP promoter. AAP 4000000129 Jodi P19838 4790 NFKB1 protein Homo sapiens 9606 P20292 241 ALOX5AP gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 THP-1 cell BTO:0001370 sickle-cell/Hb-C disease with crisis DOID:12910 lipopolysaccharide CHEBI:16412 y y PMID:15625306 LPS induction results in p50 binding to the promoter AAP 4000000130 Jodi Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P19838 4790 NFKB1 protein Homo sapiens 9606 P20292 241 ALOX5AP gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 THP-1 cell BTO:0001370 acute monocytic leukemia DOID:8864 y y PMID:15625306 overexpression of p50 and p65, together, enhances expression; expression of each protein alone does not enhance expression AAP 4000000131 Chandra P05412 3725 JUN protein Homo sapiens 9606 yes AP1 P21731 6915 TBXA2R Isoform 2 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-2 7/24/2013 143 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEK-293 cell BTO:0003320 y y PMID:15691336 AAP 4000000132 Chandra P14859 5451 POU2F1 protein Homo sapiens 9606 P21731 6915 TBXA2R Isoform 2 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-2 7/24/2013 143 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEK-293 cell BTO:0003320 y y PMID:15691336 supershift assays employing anti-Oct selective antibodies demonstrated the direct binding of Oct-1, but not Oct-2, to the Oct-1/2 element of Prm3 within HEK293 cells AAP 4000000133 Chandra P14859 5451 POU2F1 protein Homo sapiens 9606 P21731 6915 TBXA2R Isoform 2 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-2 7/24/2013 143 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HEK-293 cell BTO:0003320 y y PMID:15691336 Overexpression of Oct1 or Oct2 increases Prm3-driven luciferase assay in HEK and HEL cells AAP 4000000134 Chandra P09086 5452 POU2F2 protein Homo sapiens 9606 P21731 6915 TBXA2R Isoform 2 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-2 7/24/2013 143 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HEK-293 cell BTO:0003320 y y PMID:15691336 Overexpression of Oct1 or Oct2 increases Prm3-driven luciferase assay in HEK and HEL cells AAP 4000000135 Chandra P05412 3725 JUN protein Homo sapiens 9606 yes AP1 P21731 6915 TBXA2R Isoform 2 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-2 7/24/2013 143 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:15691336 AAP 4000000136 Chandra P05412 3725 JUN protein Homo sapiens 9606 yes AP1 P21731 6915 TBXA2R Isoform 2 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-2 7/24/2013 143 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:15691336 AAP 4000000137 Chandra P14859 5451 POU2F1 protein Homo sapiens 9606 P21731 6915 TBXA2R Isoform 2 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-2 7/24/2013 143 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:15691336 Overexpression of Oct1 or Oct2 increases Prm3-driven luciferase assay in HEK and HEL cells AAP 4000000138 Chandra P09086 5452 POU2F2 protein Homo sapiens 9606 P21731 6915 TBXA2R Isoform 2 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-2 7/24/2013 143 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:15691336 supershift assays employing anti-Oct selective antibodies demonstrated the direct binding of Oct-2, but not Oct-1, to the Oct-1/2 element of Prm3 within HEL cells AAP 4000000139 Chandra P09086 5452 POU2F2 protein Homo sapiens 9606 P21731 6915 TBXA2R Isoform 2 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-2 7/24/2013 143 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:15691336 Overexpression of Oct1 or Oct2 increases Prm3-driven luciferase assay in HEK and HEL cells AAP 4000000140 Katie P36956 6720 SREBF1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 umbilical vein endothelium UBERON:0007777 umbilical vein endothelial cell line BTO:0001520 cholesterol CHEBI:16113 y y PMID:15716578 AAP 4000000141 Katie P36956 6720 SREBF1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 umbilical vein endothelium UBERON:0007777 umbilical vein endothelial cell line BTO:0001520 cholesterol CHEBI:16113 y y PMID:15716578 Reporter assays were performed in transfected BAECs, but HUVECs were used to confirm endothelial expression of SREBPs and induction of COX-2 by lovastatin, addition of cholesterol decreased promoter activity, addition of lovastatin increased promoter activity AAP 4000000142 Katie Q12772 6721 SREBF2 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 umbilical vein endothelium UBERON:0007777 umbilical vein endothelial cell line BTO:0001520 cholesterol CHEBI:16113 y y PMID:15716578 AAP 4000000143 Katie Q12772 6721 SREBF2 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 umbilical vein endothelium UBERON:0007777 umbilical vein endothelial cell line BTO:0001520 cholesterol CHEBI:16113 y y PMID:15716578 Reporter assays were performed in transfected BAECs, but HUVECs were used to confirm endothelial expression of SREBPs and induction of COX-2 by lovastatin, addition of cholesterol decreased promoter activity, addition of lovastatin increased promoter activity, AAP 4000000144 Jodi P01100 2353 FOS protein Homo sapiens 9606 yes AP1 P05412 3725 JUN protein Homo sapiens 9606 P41222 5730 PTGDS gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 umbilical vein endothelium UBERON:0007777 HUVEC cell BTO:0001949 y y PMID:15718494 induction of L-PGDS by sheer stress AAP 4000000145 Jodi P05412 3725 JUN protein Homo sapiens 9606 yes AP1 P01100 2353 FOS protein Homo sapiens 9606 P41222 5730 PTGDS gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 umbilical vein endothelium UBERON:0007777 HUVEC cell BTO:0001949 y y PMID:15718494 induction of L-PGDS by sheer stress AAP 4000000146 Jodi Q14469 3280 HES1 protein Homo sapiens 9606 P41222 5730 PTGDS gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 TE-671 cell BTO:0002605 embryonal rhabdomyosarcoma DOID:3246 y y PMID:15743775 binding decreased by treatment with TPA or expression of PKCalpha AAP 4000000147 Jodi Q14469 3280 HES1 protein Homo sapiens 9606 P41222 5730 PTGDS gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 TE-671 cell BTO:0002605 embryonal rhabdomyosarcoma DOID:3246 y y PMID:15743775 AAP 4000000148 Jodi Q14469 3280 HES1 protein Homo sapiens 9606 P41222 5730 PTGDS gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 TE-671 cell BTO:0002605 embryonal rhabdomyosarcoma DOID:3246 y y PMID:15743775 AAP 4000000149 Jodi Q92481 7021 TFAP2B protein Homo sapiens 9606 P41222 5730 PTGDS gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 TE-671 cell BTO:0002605 embryonal rhabdomyosarcoma DOID:3246 y y PMID:15743775 binding enhanced by treatment with TPA and expression of PKCalpha AAP 4000000150 Jodi Q92481 7021 TFAP2B protein Homo sapiens 9606 P41222 5730 PTGDS gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 TE-671 cell BTO:0002605 embryonal rhabdomyosarcoma DOID:3246 y y PMID:15743775 AAP 4000000151 Chandra P01100 2353 FOS protein Homo sapiens 9606 yes AP1 P23219 5742 PTGS1 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 megakaryoblast BTO:0001164 phorbol ester CHEBI:37532 y y PMID:16105649 SP1 and AP1 act coordinately for PMA-induced expression AAP 4000000152 Chandra P05412 3725 JUN protein Homo sapiens 9606 yes AP1 P23219 5742 PTGS1 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 megakaryoblast BTO:0001164 phorbol ester CHEBI:37532 y y PMID:16105649 SP1 and AP1 act coordinately for PMA-induced expression AAP 4000000153 Chandra P08047 6667 SP1 protein Homo sapiens 9606 P23219 5742 PTGS1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 megakaryoblast BTO:0001164 phorbol ester CHEBI:37532 y y PMID:16105649 SP1 important for inducible expression in this cell line in response to PMA;COX1 promoter-luciferase assay AAP 4000000154 Chandra P37231 5468 PPARG isoform 2 protein Homo sapiens 9606 Comment/alternative products/isoform P37231-1 7/24/2013 188 yes PPARG isoform 2/RXRA P19793 6256 RXRA protein Homo sapiens 9606 P21731 6915 TBXA2R Isoform 2 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-2 7/24/2013 143 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 15-deoxy-Delta(12,14)-prostaglandin J2 CHEBI:34159 y y PMID:16156795 15-deoxy-Delta(12,14)-prostaglandin J2 represses transcription from Prm3 when both proteins co-expressed BP AAP 4000000155 Chandra P37231 5468 PPARG isoform 3 protein Homo sapiens 9606 Comment/alternative products/isoform P37231-3 7/24/2013 188 yes PPARG isoform 3/RXRA P19793 6256 RXRA protein Homo sapiens 9606 P21731 6915 TBXA2R Isoform 2 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-2 7/24/2013 143 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 15-deoxy-Delta(12,14)-prostaglandin J2 CHEBI:34159 y y PMID:16156795 15-deoxy-Delta(12,14)-prostaglandin J2 represses transcription from Prm3 when both proteins co-expressed BP AAP 4000000156 Chandra P37231 5468 PPARG isoform 2 protein Homo sapiens 9606 Comment/alternative products/isoform P37231-1 7/24/2013 188 yes PPARG isoform 2/Rxra P28700 20181 Rxra protein Mus musculus 10090 P21731 6915 TBXA2R Isoform 2 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-2 7/24/2013 143 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:16156795 in vitro tx/transl. of TFs and binding to synthetic ds DNA indicates heterodimer forms when both proteins are present and both TF half-sites are wild-type (neither mutant tolerated) BP AAP 4000000157 Chandra P37231 5468 PPARG isoform 2 protein Homo sapiens 9606 Comment/alternative products/isoform P37231-1 7/24/2013 188 P21731 6915 TBXA2R Isoform 2 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-2 7/24/2013 143 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:16156795 in vitro tx/transl. of TFs and EMSA with synthetic ds DNA indicates some binding to DNA by single TF BP AAP 4000000158 Chandra P28700 20181 Rxra protein Mus musculus 10090 P21731 6915 TBXA2R Isoform 2 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-2 7/24/2013 143 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:16156795 in vitro tx/transl. of TFs and EMSA with synthetic ds DNA indicates some binding to DNA by single TF AAP 4000000159 Jodi P19793 6256 RXRA protein Homo sapiens 9606 yes VDR/RXR P09917 240 ALOX5 gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 Mono-Mac-6 cell BTO:0002333 acute monocytic leukemia DOID:8864 y y PMID:16750418 AAP 4000000160 Jodi P11473 7421 VDR protein Homo sapiens 9606 yes VDR/RXR P09917 240 ALOX5 gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 myeloid cell line BTO:0000906 y y PMID:16750418 AAP 4000000161 Jodi P11473 7421 VDR protein Homo sapiens 9606 P09917 240 ALOX5 gene Homo sapiens 9606 nucleic acid binding evidence ECO:0000136 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:16750418 DNase footprinting AAP 4000000162 Katie O95863 6615 SNAI1 protein Homo sapiens 9606 P15428 3248 HPGD gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 colonic cancer cell line BTO:0000797 colon carcinoma DOID:1520 y y PMID:16818638 EGF represses HPGD expression in colon cancer cell lines via SNAIL, also measured HPGD expression in tumor tissue AAP 4000000163 Katie O95863 6615 SNAI1 protein Homo sapiens 9606 P15428 3248 HPGD gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 colonic cancer cell line BTO:0000797 colon carcinoma DOID:1520 y y PMID:16818638 EGF represses HPGD expression in colon cancer cell lines via SNAIL, also measured HPGD expression in tumor tissue AAP 4000000164 Jodi Q04206 5970 RELA protein Homo sapiens 9606 P43088 5737 PTGFR gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 myometrium UBERON:0001296 myometrium BTO:0000907 y y PMID:16855208 ULTR cells treated with interleukin 1beta; NFKB response element of PTGFR promoter tested AAP 4000000165 Jodi Q04206 5970 RELA protein Homo sapiens 9606 P43088 5737 PTGFR gene Homo sapiens 9606 transcript expression level evidence ECO:0000048 positive regulation of gene expression GO:0010628 myometrium UBERON:0001296 myometrium BTO:0000907 y y PMID:16855208 ULTR cells treated with IL1B leads to nuclear translocation of RELA and increased PTGFR mRNA levels; preventing translocation reduces mRNA levels AAP 4000000166 Jodi Q04887 20682 Sox9 protein Mus musculus 10090 O09114 19215 Ptgds gene Mus musculus 10090 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HEK-293 cell BTO:0000007 y y PMID:17277314 SOX9 binds as a dimer to the paired SOX site (SOX-A and SOX-B) 4000000167 Jodi Q04887 20682 Sox9 protein Mus musculus 10090 O09114 19215 Ptgds gene Mus musculus 10090 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 Sertoli cell BTO:0001238 y y PMID:17277314 SOX9 binds the paired SOX sites in XY genital ridges 4000000168 Jodi Q04887 20682 Sox9 protein Mus musculus 10090 O09114 19215 Ptgds gene Mus musculus 10090 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:17277314 Recombinant bacterially expressed GST fusion protein (full length Sox9) used 4000000169 Jodi Q05738 21674 Sry protein Mus musculus 10090 O09114 19215 Ptgds gene Mus musculus 10090 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:17277314 Recombinant bacterially expressed GST fusion protein (full length Sry) used 4000000170 Chandra P08047 6667 SP1 protein Homo sapiens 9606 no Q16647 5740 PTGIS gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 NCI-H226 cell BTO:0003008 malignant pleural mesothelioma DOID:7474 y y PMID:17374734 AAP 4000000171 Jodi P45448 26424 Nr5a2 protein Mus musculus 10090 O09114 19215 Ptgds gene Mus musculus 10090 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 3T3-L1 cell BTO:0000011 y y PMID:17439953 4000000172 Jodi P45448 26424 Nr5a2 protein Mus musculus 10090 O09114 19215 Ptgds gene Mus musculus 10090 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 3T3-L1 cell BTO:0000011 y y PMID:17439953 repression of LRH-1 expression by siRNA prevents expression of L-PGDS mRNA in preadipoc;ytic cells 4000000173 Jodi Q9WTN3 20787 Srebf1 protein Mus musculus 10090 O09114 19215 Ptgds gene Mus musculus 10090 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 3T3-L1 cell BTO:0000011 y y PMID:17439953 adipocytic 3T3-L1 cells 4000000174 Katie Q09472 2033 EP300 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 cervical cancer cell line BTO:0001967 Homo sapiens papilloma virus related cervical squamous cell carcinoma DOID:7834 y y PMID:17440114 Investigated COX-2 induction by HPV in cervical cancer cells lines AAP 4000000175 Katie P01100 2353 FOS protein Homo sapiens 9606 yes AP1 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 cervical cancer cell line BTO:0001967 Homo sapiens papilloma virus related cervical squamous cell carcinoma DOID:7834 y y PMID:17440114 Investigated COX-2 induction by HPV in cervical cancer cells lines AAP 4000000176 Katie O15379 8841 HDAC3 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 cervical cancer cell line BTO:0001967 Homo sapiens papilloma virus related cervical squamous cell carcinoma DOID:7834 y y PMID:17440114 Investigated COX-2 induction by HPV in cervical cancer cells lines AAP 4000000177 Katie P05412 3725 JUN protein Homo sapiens 9606 yes AP1 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 cervical cancer cell line BTO:0001967 Homo sapiens papilloma virus related cervical squamous cell carcinoma DOID:7834 y y PMID:17440114 Investigated COX-2 induction by HPV in cervical cancer cells lines AAP 4000000178 Katie O75376 9611 NCOR1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 cervical cancer cell line BTO:0001967 Homo sapiens papilloma virus related cervical squamous cell carcinoma DOID:7834 y y PMID:17440114 Investigated COX-2 induction by HPV in cervical cancer cells lines AAP 4000000179 Katie O75376 9611 NCOR1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 cervical cancer cell line BTO:0001967 Homo sapiens papilloma virus related cervical squamous cell carcinoma DOID:7834 y y PMID:17440114 Investigated COX-2 induction by HPV in cervical cancer cells lines AAP 4000000180 Katie Q9BZK7 79718 TBL1XR1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 cervical cancer cell line BTO:0001967 Homo sapiens papilloma virus related cervical squamous cell carcinoma DOID:7834 y y PMID:17440114 Investigated COX-2 induction by HPV in cervical cancer cells lines AAP 4000000181 Katie Q9BZK7 79718 TBL1XR1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 cervical cancer cell line BTO:0001967 Homo sapiens papilloma virus related cervical squamous cell carcinoma DOID:7834 y y PMID:17440114 Investigated COX-2 induction by HPV in cervical cancer cells lines AAP 4000000182 Katie P51668 7321 UBE2D1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 cervical cancer cell line BTO:0001967 Homo sapiens papilloma virus related cervical squamous cell carcinoma DOID:7834 y y PMID:17440114 Investigated COX-2 induction by HPV in cervical cancer cells lines AAP 4000000183 Jodi P19793 6256 RXRA protein Homo sapiens 9606 yes VDR/RXR P09917 240 ALOX5 gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 Mono-Mac-6 cell BTO:0002333 acute monocytic leukemia DOID:8864 y y PMID:17500032 cells treated with 1,25-dihydroxyvitamin D3 AAP 4000000184 Jodi P28702 6257 RXRB protein Homo sapiens 9606 yes VDR/RXR P09917 240 ALOX5 gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 Mono-Mac-6 cell BTO:0002333 acute monocytic leukemia DOID:8864 y y PMID:17500032 cells treated with 1,25-dihydroxyvitamin D3 AAP 4000000185 Jodi P11473 7421 VDR protein Homo sapiens 9606 yes VDR/RXR P19793|P28702 6256|6257 RXRA|RXRB protein Homo sapiens 9606 P09917 240 ALOX5 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 Mono-Mac-6 cell BTO:0002333 y y PMID:17500032 AAP 4000000186 Jodi P11473 7421 VDR protein Homo sapiens 9606 yes VDR/RXR P19793|P28702 6256|6257 RXRA|RXRB protein Homo sapiens 9606 P09917 240 ALOX5 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 Mono-Mac-6 cell BTO:0002333 y y PMID:17500032 cells treated with 1,25-dihydroxyvitamin D3 AAP 4000000187 Jodi P11473 7421 VDR protein Homo sapiens 9606 yes VDR/RXR P09917 240 ALOX5 gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 myeloid cell line BTO:0000906 y y PMID:17500032 cells treated with 1,25-dihydroxyvitamin D3 AAP 4000000188 Katie O43623 6591 SNAI2 protein Homo sapiens 9606 P15428 3248 HPGD gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 lung cancer cell line BTO:0000762 non-small cell lung carcinoma DOID:3908 y y PMID:17575121 EGF represses HPGD expression in non-small cell lung cancer via SLUG, also measured HPGD expression in tumor tissue AAP 4000000189 Katie O43623 6591 SNAI2 protein Homo sapiens 9606 P15428 3248 HPGD gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 lung cancer cell line BTO:0000762 non-small cell lung carcinoma DOID:3908 y y PMID:17575121 EGF represses HPGD expression in non-small cell lung cancer via SLUG, also measured HPGD expression in tumor tissue, reporter assay done in transfected Mus musculus NIH3T3 cells AAP 4000000190 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P09917 240 ALOX5 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 trichostatin A CHEBI:46024 y y PMID:17894944 AAP 4000000191 Jodi Q02447 6670 SP3 protein Homo sapiens 9606 P09917 240 ALOX5 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 trichostatin A CHEBI:46024 y y PMID:17894944 AAP 4000000192 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P09917 240 ALOX5 gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 Mono-Mac-6 cell BTO:0002333 acute monocytic leukemia DOID:8864 trichostatin A CHEBI:46024 y y PMID:17894944 AAP 4000000193 Jodi Q02447 6670 SP3 protein Homo sapiens 9606 P09917 240 ALOX5 gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 Mono-Mac-6 cell BTO:0002333 acute monocytic leukemia DOID:8864 trichostatin A CHEBI:46024 y y PMID:17894944 AAP 4000000194 Jodi P23771 2625 GATA3 protein Homo sapiens 9606 Q9Y5Y4 11251 PTGDR2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 JURKAT cell BTO:0000661 acute T cell leukemia DOID:5603 y y PMID:17910949 AAP 4000000195 Jodi P23771 2625 GATA3 protein Homo sapiens 9606 Q9Y5Y4 11251 PTGDR2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:17910949 GATA3 protein synthesized in vitro; DNA-protein complex supershifted by anti-GATA3 antibodies AAP 4000000196 Chandra Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB O14684 9536 PTGES gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 amnion UBERON:0000305 mesenchymal cell BTO:0002625 y y PMID:17928629 NFkB induction of PTGES following stimulation of primary amnion mesenchymal cells with IL1B AAP 4000000197 Chandra Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB O14684 9536 PTGES gene Homo sapiens 9606 transcriptional activation assay ECO:0000170 positive regulation of gene expression GO:0010628 amnion UBERON:0000305 mesenchymal cell BTO:0002625 y y PMID:17928629 NFkB induction of PTGES following stim. of primary amnion mesenchymal cells with IL1B; NFkB inhibitors and Dominant negative IkB block the induction of mRNAs AAP 4000000198 Chandra Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P35354 5743 PTGS2 gene Homo sapiens 9606 transcriptional activation assay ECO:0000170 positive regulation of gene expression GO:0010628 amnion UBERON:0000305 mesenchymal cell BTO:0002625 y y PMID:17928629 NFkB induction of PTGS2 following stim. of primary amnion mesenchymal cells with IL1B; NFkB inhibitors and Dominant negative IkB block the induction of mRNAs AAP 4000000199 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P35408 5734 PTGER4 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 T-98G cell BTO:0001583 brain glioblastoma multiforme DOID:3073 y y PMID:18346464 AAP 4000000200 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P35408 5734 PTGER4 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 T-98G cell BTO:0001583 brain glioblastoma multiforme DOID:3073 y y PMID:18346464 AAP 4000000201 Katie Q9Y261 3170 FOXA2 protein Homo sapiens 9606 P15428 3248 HPGD gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 lung cancer cell line BTO:0000762 lung cancer DOID:1324 y y PMID:18593902 HNF3b (tet-off) was transfected into a lung cancer cell line, removal of doxycycline in culture induced HNF3b and HPGD expression AAP 4000000202 Katie Q9Y261 3170 FOXA2 protein Homo sapiens 9606 P15428 3248 HPGD gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 lung cancer cell line BTO:0000762 lung cancer DOID:1324 y y PMID:18593902 HNF3b (tet-off) was transfected into a lung cancer cell line, removal of doxycycline in culture induced HNF3b and HPGD expression AAP 4000000203 Katie P47902 1044 CDX1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 gastric cancer cell line BTO:0000787 stomach carcinoma DOID:5517 deoxycholic acid CHEBI:28834 y y PMID:18775915 AAP 4000000204 Katie P47902 1044 CDX1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 gastric cancer cell line BTO:0000787 stomach carcinoma DOID:5517 deoxycholic acid CHEBI:28834 y y PMID:18775915 AAP 4000000205 Jodi P22415 7391 USF1 protein Homo sapiens 9606 P41222 5730 PTGDS gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 TE-671 cell BTO:0002605 embryonal rhabdomyosarcoma DOID:3246 y y PMID:18817855 aE-box of intron 4 of PTGDS; binding efficiency enhanced in serum-starved medium AAP 4000000206 Jodi P22415 7391 USF1 protein Homo sapiens 9606 P41222 5730 PTGDS gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 TE-671 cell BTO:0002605 embryonal rhabdomyosarcoma DOID:3246 y y PMID:18817855 aE-box of intron 4 of PTGDS; binding enhanced in serum-starved medium AAP 4000000207 Jodi P22415 7391 USF1 protein Homo sapiens 9606 P41222 5730 PTGDS gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 TE-671 cell BTO:0002605 embryonal rhabdomyosarcoma DOID:3246 y y PMID:18817855 serum starved cells; expression enhanced for reporter containing intron 4 AAP 4000000208 Jodi Q15853 7392 USF2 protein Homo sapiens 9606 P41222 5730 PTGDS gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 TE-671 cell BTO:0002605 embryonal rhabdomyosarcoma DOID:3246 y y PMID:18817855 aE-box of intron 4 of PTGDS AAP 4000000209 Jodi Q16665 3091 HIF1A protein Homo sapiens 9606 P20292 241 ALOX5AP gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 THP-1 cell BTO:0001370 acute monocytic leukemia DOID:8864 y y PMID:18945963 placenta growth factor induces HIF-1alpha binding AAP 4000000210 Jodi Q16665 3091 HIF1A protein Homo sapiens 9606 P20292 241 ALOX5AP gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 THP-1 cell BTO:0001370 acute monocytic leukemia DOID:8864 y y PMID:18945963 placenta growth factor (PlGF) induces ALOX5AP expression through HIF1A AAP 4000000211 Jodi P19838 4790 NFKB1 protein Homo sapiens 9606 yes NFkB P19440 2678 GGT1 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 K-562 cell BTO:0000664 chronic myeloid leukemia DOID:8552 y y PMID:18996094 tumor necrosis factor alpha increases binding AAP 4000000212 Jodi P19838 4790 NFKB1 protein Homo sapiens 9606 yes NFkB P19440 2678 GGT1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 K-562 cell BTO:0000664 chronic myeloid leukemia DOID:8552 y y PMID:18996094 evidence of regulator affecting expression comes from adding anti-p50 siRNA; tumor necrosis factor alpha induces expression AAP 4000000213 Jodi Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P19440 2678 GGT1 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 K-562 cell BTO:0000664 chronic myeloid leukemia DOID:8552 y y PMID:18996094 AAP 4000000214 Jodi Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P19440 2678 GGT1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 K-562 cell BTO:0000664 chronic myeloid leukemia DOID:8552 y y PMID:18996094 evidence of regulator affecting expression comes from adding anti-p65 siRNA; tumor necrosis factor alpha induces expression AAP 4000000215 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P19440 2678 GGT1 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 K-562 cell BTO:0000664 chronic myeloid leukemia DOID:8552 y y PMID:18996094 tumor necrosis factor alpha increases binding AAP 4000000216 Chandra P18146 1958 EGR1 protein Homo sapiens 9606 P21731 6915 TBXA2R Isoform 1 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-3 7/24/2013 143 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19067769 Promoter 1 binding data; use of Prm1 leads to generation of thromboxane A2 receptor alpha AAP 4000000217 Chandra P18146 1958 EGR1 protein Homo sapiens 9606 P21731 6915 TBXA2R Isoform 1 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-3 7/24/2013 143 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19067769 Promoter 1 binding but element closer to start AAP 4000000218 Chandra P18146 1958 EGR1 protein Homo sapiens 9606 P21731 6915 TBXA2R Isoform 1 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-3 7/24/2013 143 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19067769 Promoter 1 binding data; use of Prm1 leads to generation of thromboxane A2 receptor alpha AAP 4000000219 Chandra P08047 6667 SP1 protein Homo sapiens 9606 yes Transcription Factor Complex P18146|P19544|P19544 1958|7490 EGR1|WT1 isoform 2|WT1 isoform 4 protein Homo sapiens 9606 Comment/alternative products/isoform|Comment/alternative products/isoform|Comment/alternative products/isoform P18146-1|P19544-2|P19544-4 7/24/2013|7/24/2013|7/24/2013 135|175|175 P21731 6915 TBXA2R Isoform 1 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-3 7/24/2013 143 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 Y Y PMID:19067769 Promoter 1 binding data; Full length protein P18146 entered as P18146-1 in Regulator, Additional Data Value AAP 4000000220 Chandra P08047 6667 SP1 protein Homo sapiens 9606 P21731 6915 TBXA2R Isoform 1 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-3 7/24/2013 143 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19067769 Promoter 1 binding data AAP 4000000221 Chandra P19544 7490 WT1 isoform 2 protein Homo sapiens 9606 Comment/alternative products/isoform P19544-2 7/24/2013 175 P21731 6915 TBXA2R Isoform 1 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-3 7/24/2013 143 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19067769 two isoforms of WT1 are expressed in the HEL cells and multiple-sized complexes are formed and competed in the EMSA; because of this and because two isoforms of WT1 lacking the KTS motifs can repress transcription from the Promoter 1 of TBXA2R, both isoforms are documented AAP 4000000222 Chandra P19544 7490 WT1 isoform 2 protein Homo sapiens 9606 Comment/alternative products/isoform P19544-2 7/24/2013 175 P21731 6915 TBXA2R Isoform 1 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-3 7/24/2013 143 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19067769 Promoter 1 binding data; use of Prm1 leads to generation of thromboxane A2 receptor alpha AAP 4000000223 Chandra P19544 7490 WT1 isoform 2 protein Homo sapiens 9606 Comment/alternative products/isoform P19544-2 7/24/2013 175 P21731 6915 TBXA2R Isoform 1 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-3 7/24/2013 143 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19067769 WT1, isoform 2, lacks KTS domain and Exon 5 AAP 4000000224 Chandra P19544 7490 WT1 isoform 4 protein Homo sapiens 9606 Comment/alternative products/isoform P19544-4 7/24/2013 175 P21731 6915 TBXA2R Isoform 1 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-3 7/24/2013 143 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19067769 two isoforms of WT1 are expressed in the HEL cells and multiple-sized complexes are formed and competed in the EMSA; because of this and because two isoforms of WT1 lacking the KTS motifs can repress transcription from the Promoter 1 of TBXA2R, both isoforms are documented AAP 4000000225 Chandra P19544 7490 WT1 isoform 4 protein Homo sapiens 9606 Comment/alternative products/isoform P19544-4 7/24/2013 175 P21731 6915 TBXA2R Isoform 1 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-3 7/24/2013 143 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19067769 Promoter 1 binding data; use of Prm1 leads to generation of thromboxane A2 receptor alpha AAP 4000000226 Chandra P19544 7490 WT1 isoform 4 protein Homo sapiens 9606 Comment/alternative products/isoform P19544-4 7/24/2013 175 P21731 6915 TBXA2R Isoform 1 gene Homo sapiens 9606 Comment/alternative products/isoform P21731-3 7/24/2013 143 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19067769 WT1, isoform 2, lacks KTS domain and Exon 5 AAP 4000000227 Jodi Q01543 2313 FLI1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 EAhy 926 cell BTO:0000396 y y PMID:19118563 basal transcriptionial regulatory region AAP 4000000228 Jodi P14859 5451 POU2F1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 EAhy 926 cell BTO:0000396 y y PMID:19118563 AAP 4000000229 Jodi P14859 5451 POU2F1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 EAhy 926 cell BTO:0000396 y y PMID:19118563 basal transcriptionial regulatory region AAP 4000000230 Jodi P14859 5451 POU2F1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 transcript expression level evidence ECO:0000048 positive regulation of gene expression GO:0010628 EAhy 926 cell BTO:0000396 y y PMID:19118563 basal transcriptionial regulatory region AAP 4000000231 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 EAhy 926 cell BTO:0000396 y y PMID:19118563 AAP 4000000232 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 transcript expression level evidence ECO:0000048 positive regulation of gene expression GO:0010628 EAhy 926 cell BTO:0000396 y y PMID:19118563 basal transcriptionial regulatory region AAP 4000000233 Jodi P17947 6688 SPI1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 EAhy 926 cell BTO:0000396 y y PMID:19118563 AAP 4000000234 Jodi P17947 6688 SPI1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 EAhy 926 cell BTO:0000396 y y PMID:19118563 basal transcriptionial regulatory region AAP 4000000235 Jodi P17947 6688 SPI1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 transcript expression level evidence ECO:0000048 positive regulation of gene expression GO:0010628 EAhy 926 cell BTO:0000396 y y PMID:19118563 basal transcriptionial regulatory region AAP 4000000236 Jodi Q01543 2313 FLI1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19118563 No ChIP occurs with FLI1, indicating binding may not be relevant in vivo AAP 4000000237 Jodi Q01543 2313 FLI1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19118563 basal transcriptionial regulatory region AAP 4000000238 Jodi P14859 5451 POU2F1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19118563 AAP 4000000239 Jodi P14859 5451 POU2F1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19118563 AAP 4000000240 Jodi P14859 5451 POU2F1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19118563 basal transcriptionial regulatory region AAP 4000000241 Jodi P14859 5451 POU2F1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 transcript expression level evidence ECO:0000048 positive regulation of gene expression GO:0010628 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19118563 basal transcriptionial regulatory region AAP 4000000242 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19118563 AAP 4000000243 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19118563 AAP 4000000244 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 transcript expression level evidence ECO:0000048 positive regulation of gene expression GO:0010628 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19118563 basal transcriptionial regulatory region AAP 4000000245 Jodi P17947 6688 SPI1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19118563 AAP 4000000246 Jodi P17947 6688 SPI1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19118563 AAP 4000000247 Jodi P17947 6688 SPI1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19118563 basal transcriptionial regulatory region AAP 4000000248 Jodi P17947 6688 SPI1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 transcript expression level evidence ECO:0000048 positive regulation of gene expression GO:0010628 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:19118563 basal transcriptionial regulatory region AAP 4000000249 Jodi P17433 20375 Spi1 protein Mus musculus 10090 yes P05627 16476 Jun protein Mus musculus 10090 O09114 19215 Ptgds gene Mus musculus 10090 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 bone marrow-derived macrophage BTO:0004732 lipopolysaccharide CHEBI:16412 y y PMID:19181746 4000000250 Jodi P05627 16476 Jun protein Mus musculus 10090 yes P17433 20375 Spi1 protein Mus musculus 10090 O09114 19215 Ptgds gene Mus musculus 10090 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 RAW-264.7 cell BTO:0003292 lipopolysaccharide CHEBI:16412 y y PMID:19181746 4000000251 Jodi P17433 20375 Spi1 protein Mus musculus 10090 O09114 19215 Ptgds gene Mus musculus 10090 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 RAW-264.7 cell BTO:0003292 y y PMID:19181746 L-PGDS levels measured 4000000252 Jodi Q61221 15251 Hif1a protein Mus musculus 10090 P35375 19216 Ptger1 gene Mus musculus 10090 antisense exeriment evidence ECO:0000018 positive regulation of gene expression GO:0010628 MC3T3-E1 cell BTO:0001957 y y PMID:19277991 siRNA against HIF1A leads to lower EP1 protein levels 4000000253 Katie P28702 6257 RXRB protein Homo sapiens 9606 yes TR/RXR P15121 231 AKR1B1 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 liver cancer cell BTO:0000594 hepatocellular carcinoma DOID:684 y y PMID:19422879 T3 induces AKR1B1 expression AAP 4000000254 Katie P10827 7067 THRA protein Homo sapiens 9606 yes TR-alpha homodimer P15121 231 AKR1B1 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 liver cancer cell BTO:0000594 hepatocellular carcinoma DOID:684 y y PMID:19422879 T3 induces AKR1B1 expression AAP 4000000255 Katie P10827 7067 THRA protein Homo sapiens 9606 yes TR-alpha homodimer, TR/RXR heterodimer P15121 231 AKR1B1 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 liver cancer cell BTO:0000594 hepatocellular carcinoma DOID:684 y y PMID:19422879 T3 induces AKR1B1 expression AAP 4000000256 Katie P10827 7067 THRA protein Homo sapiens 9606 yes TR-alpha homodimer P15121 231 AKR1B1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 liver cancer cell BTO:0000594 hepatocellular carcinoma DOID:684 y y PMID:19422879 T3 induces AKR1B1 expression AAP 4000000257 Katie P10828 7068 THRB protein Homo sapiens 9606 yes TR-beta homodimer P15121 231 AKR1B1 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 liver cancer cell BTO:0000594 hepatocellular carcinoma DOID:684 y y PMID:19422879 T3 induces AKR1B1 expression AAP 4000000258 Katie P10828 7068 THRB protein Homo sapiens 9606 yes TR-beta homodimer, TR/RXR heterodimer P15121 231 AKR1B1 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 liver cancer cell BTO:0000594 hepatocellular carcinoma DOID:684 y y PMID:19422879 T3 induces AKR1B1 expression AAP 4000000259 Katie P10828 7068 THRB protein Homo sapiens 9606 yes TR-beta homodimer P15121 231 AKR1B1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 liver cancer cell BTO:0000594 hepatocellular carcinoma DOID:684 y y PMID:19422879 T3 induces AKR1B1 expression AAP 4000000260 Jodi P18146 1958 EGR1 protein Homo sapiens 9606 P35408 5734 PTGER4 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 T-98G cell BTO:0001583 brain glioblastoma multiforme DOID:3073 y y PMID:19934343 AAP 4000000261 Jodi P18146 1958 EGR1 protein Homo sapiens 9606 P35408 5734 PTGER4 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 T-98G cell BTO:0001583 brain glioblastoma multiforme DOID:3073 sulindac CHEBI:9352 y y PMID:19934343 AAP 4000000262 Jodi P18146 1958 EGR1 protein Homo sapiens 9606 P35408 5734 PTGER4 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 T-98G cell BTO:0001583 brain glioblastoma multiforme DOID:3073 y y PMID:19934343 AAP 4000000263 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P35408 5734 PTGER4 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 T-98G cell BTO:0001583 brain glioblastoma multiforme DOID:3073 y y PMID:19934343 AAP 4000000264 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P35408 5734 PTGER4 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 T-98G cell BTO:0001583 brain glioblastoma multiforme DOID:3073 sulindac CHEBI:9352 y y PMID:19934343 AAP 4000000265 Jodi P03372 2099 ESR1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 thoracic aorta UBERON:0001515 aortic smooth muscle cell BTO:0004577 17beta-estradiol CHEBI:16469 y y PMID:20070947 Homo sapiens aortic smooth muscle cells; binding enhanced by 17beta-estradiol AAP 4000000266 Jodi P03372 2099 ESR1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 EAhy 926 cell BTO:0000396 17beta-estradiol CHEBI:16469 y y PMID:20070947 AAP 4000000267 Jodi P03372 2099 ESR1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 EAhy 926 cell BTO:0000396 17beta-estradiol CHEBI:16469 y y PMID:20070947 AAP 4000000268 Jodi P03372 2099 ESR1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 HEL cell BTO:0000565 leukemia DOID:1240 17beta-estradiol CHEBI:16469 y y PMID:20070947 AAP 4000000269 Jodi P03372 2099 ESR1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL cell BTO:0000565 leukemia DOID:1240 y y PMID:20070947 AAP 4000000270 Jodi P03372 2099 ESR1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HEL cell BTO:0000565 leukemia DOID:1240 17beta-estradiol CHEBI:16469 y y PMID:20070947 AAP 4000000271 Katie P00533 1956 EGFR protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 glioblastoma cell line BTO:0001530 glioblastoma DOID:3068 y y PMID:20145033 EGFR interacts with STAT3 to induce COX-2 expression, also measured COX-2 and EGFR expression in glioma tissue AAP 4000000272 Katie P00533 1956 EGFR protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 glioblastoma cell line BTO:0001530 glioblastoma DOID:3068 y y PMID:20145033 EGFR interacts with STAT3 to induce COX-2 expression, also measured COX-2 and EGFR expression in glioma tissue AAP 4000000273 Katie P40763 6774 STAT3 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 glioblastoma cell line BTO:0001530 glioblastoma DOID:3068 y y PMID:20145033 EGFR interacts with STAT3 to induce COX-2 expression, also measured COX-2 and EGFR expression in glioma tissue AAP 4000000274 Katie P40763 6774 STAT3 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 glioblastoma cell line BTO:0001530 glioblastoma DOID:3068 y y PMID:20145033 EGFR interacts with STAT3 to induce COX-2 expression, also measured COX-2 and EGFR expression in glioma tissue AAP 4000000275 Jodi Q01196 861 RUNX1 protein Homo sapiens 9606 P18054 239 ALOX12 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEL cell BTO:0000565 leukemia DOID:1240 y y PMID:20181616 AAP 4000000276 Jodi Q01196 861 RUNX1 protein Homo sapiens 9606 P18054 239 ALOX12 gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 HEL cell BTO:0000565 leukemia DOID:1240 y y PMID:20181616 AAP 4000000277 Jodi Q01196 861 RUNX1 protein Homo sapiens 9606 P18054 239 ALOX12 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HEL cell BTO:0000565 leukemia DOID:1240 y y PMID:20181616 siRNA knockdown of RUNX1 gene affects promoter activity; overexpression increases activity AAP 4000000278 Jodi Q9Z2J9 367218 Runx2 protein Rattus norvegicus 10116 P22057 25526 Ptgds gene Rattus norvegicus 10116 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 granulosa cell BTO:0000542 y y PMID:20197312 4000000279 Jodi Q9Z2J9 367218 Runx2 protein Rattus norvegicus 10116 P22057 25526 Ptgds gene Rattus norvegicus 10116 microarray RNA expression level evidence ECO:0000104 positive regulation of gene expression GO:0010628 granulosa cell BTO:0000542 y y PMID:20197312 granulosa cells treated with forskolin and Runx2 siRNA compared to cells treated with scrambled siRNA 4000000280 Jodi Q01196 861 RUNX1 protein Homo sapiens 9606 Q15722 1241 LTB4R gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 blood UBERON:0000178 HL-60 cell BTO:0000738 acute myeloid leukemia DOID:9119 y y PMID:20395453 nuclear extracts assayed for promoter binding, and anti-RUNX1 antibody addition caused complexes to supershift AAP 4000000281 Jodi Q01196 861 RUNX1 protein Homo sapiens 9606 Q15722 1241 LTB4R gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 blood UBERON:0000178 HL-60 cell BTO:0000738 acute myeloid leukemia DOID:9119 y y PMID:20395453 RA stimulates expression, possibly by loosening the chromatin structure, facilitating accessibility to RUNX1 protein AAP 4000000282 Jodi Q01196 861 RUNX1 protein Homo sapiens 9606 Q15722 1241 LTB4R gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 blood UBERON:0000178 HL-60 cell BTO:0000738 acute myeloid leukemia DOID:9119 y y PMID:20395453 AAP 4000000283 Jodi Q01196 861 RUNX1 protein Homo sapiens 9606 Q15722 1241 LTB4R gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 blood UBERON:0000178 leukocyte BTO:0000751 y y PMID:20395453 AAP 4000000284 Jodi Q01196 861 RUNX1 protein Homo sapiens 9606 Q15722 1241 LTB4R gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 THP-1 cell BTO:0001370 acute monocytic leukemia DOID:8864 y y PMID:20395453 AAP 4000000285 Katie O43623 6591 SNAI2 protein Homo sapiens 9606 P15428 3248 HPGD gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 keratinocyte cell line BTO:0000375 y y PMID:20643784 UV radiation exposure upregulates COX-2 and suppresses HPGD AAP 4000000286 Jodi P16220 1385 CREB1 protein Homo sapiens 9606 P16050 246 ALOX15 gene Homo sapiens 9606 transcriptional activation assay ECO:0000170 regulation of gene expression GO:0010468 monocyte BTO:0000876 y y PMID:20861348 transcription activation measured in the presence of IL-13 and presence or absence of decoy ODNs for the Egr-1 and CREB consensus binding sites AAP 4000000287 Jodi P16220 1385 CREB1 protein Homo sapiens 9606 P16050 246 ALOX15 gene Homo sapiens 9606 enzyme-linked immunoabsorbent assay evidence ECO:0000267 direct interaction MI:0407 DNA binding GO:0003677 monocyte BTO:0000876 y y PMID:20861348 IL-13 induction of CREB activation; primary human monocytes AAP 4000000288 Jodi P18146 1958 EGR1 protein Homo sapiens 9606 P16050 246 ALOX15 gene Homo sapiens 9606 transcriptional activation assay ECO:0000170 regulation of gene expression GO:0010468 monocyte BTO:0000876 y y PMID:20861348 transcription activation measured in the presence of IL-13 and presence or absence of decoy ODNs for the Egr-1 and CREB consensus binding sites AAP 4000000289 Jodi P18146 1958 EGR1 protein Homo sapiens 9606 P16050 246 ALOX15 gene Homo sapiens 9606 enzyme-linked immunoabsorbent assay evidence ECO:0000267 direct interaction MI:0407 DNA binding GO:0003677 monocyte BTO:0000876 y y PMID:20861348 IL-13 induced nuclear accumulation and activation of Egr-1 DNA binding activity; primary human monocytes AAP 4000000290 Jodi Q16665 3091 HIF1A protein Homo sapiens 9606 P16152 873 CBR1 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 Hep-G2 cell BTO:0000599 hepatocellular carcinoma DOID:684 y y PMID:21056497 nuclear extracts incubated under hypoxic conditions AAP 4000000291 Jodi Q16665 3091 HIF1A protein Homo sapiens 9606 P16152 873 CBR1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 Hep-G2 cell BTO:0000599 hepatocellular carcinoma DOID:684 y y PMID:21056497 hypoxic conditions AAP 4000000292 Jodi Q16665 3091 HIF1A protein Homo sapiens 9606 P16152 873 CBR1 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:21056497 AAP 4000000293 Katie P17676 1051 CEBPB protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 lung cancer cell line BTO:0000762 lung cancer DOID:1324 y y PMID:21150337 Used cigarette smoke extract to induce COX-2 AAP 4000000294 Katie P43268 2118 ETV4 protein Homo sapiens 9606 Q15831 6794 STK11 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 lung cancer cell line BTO:0000762 lung cancer DOID:1324 y y PMID:21150337 Used cigarette smoke extract to induce COX-2, also showed that LKB1 interacts with PEA3 and p63 AAP 4000000295 Katie P23511 4800 NFYA protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 lung cancer cell line BTO:0000762 lung cancer DOID:1324 y y PMID:21150337 Used cigarette smoke extract to induce COX-2 AAP 4000000296 Katie Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 lung cancer cell line BTO:0000762 lung cancer DOID:1324 y y PMID:21150337 Used cigarette smoke extract to induce COX-2, only used p65 antibody to detect NFkB AAP 4000000297 Katie Q9H3D4 8626 TP63 protein Homo sapiens 9606 Q15831 6794 STK11 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 lung cancer cell line BTO:0000762 lung cancer DOID:1324 y y PMID:21150337 Used cigarette smoke extract to induce COX-2, also showed that LKB1 interacts with PEA3 and p63, measured DeltaNp63-alpha isoform AAP 4000000298 Katie P18848 468 ATF4 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 liver cell line BTO:0000224 hepatitis B DOID:2043 y y PMID:21244365 Simulated hepatitis B infection by transfecting liver cell lines with HBV X protein AAP 4000000299 Katie P18848 468 ATF4 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 liver cell line BTO:0000224 hepatitis B DOID:2043 y y PMID:21244365 Simulated hepatitis B infection by transfecting liver cell lines with HBV X protein AAP 4000000300 Katie P47902 1044 CDX1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 endometrial cell line BTO:0001996 endometriosis DOID:289 y y PMID:21613300 COX-2 expression was induced by hypoxia, no evidence that CDX1 actually binds directly to PTGS2 sequence AAP 4000000301 Jodi P37231 5468 PPARG protein Homo sapiens 9606 Q9JHF7 54486 Hpgds gene Mus musculus 10090 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HEK-293T cell BTO:0002181 y y PMID:21669866 Mus musculus Hpgds promoter contains 4 PPREs; PPRE1 shows strong binding to PPARgamma, while PPRE2 and 4 show minimal binding and PPRE3 does not bind. BP 4000000302 Jodi P37238 19016 Pparg protein Mus musculus 10090 Q9JHF7 54486 Hpgds gene Mus musculus 10090 protein expression level evidence ECO:0000046 positive regulation of gene expression GO:0010628 RAW-264.7 cell BTO:0003292 rosiglitazone CHEBI:50122 y y PMID:21669866 rosiglitazone, an agonist of PPARG, increased HPGDS expression in selenium-deficient cells 4000000303 Jodi Q16236 4780 NFE2L2 protein Homo sapiens 9606 O75828 874 CBR3 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 Hep-G2 cell BTO:0000599 hepatocellular carcinoma DOID:684 y y PMID:22001310 cells treated with tert-butyl hydroquinone (t-BHQ) AAP 4000000304 Jodi Q16236 4780 NFE2L2 protein Homo sapiens 9606 O75828 874 CBR3 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 Hep-G2 cell BTO:0000599 hepatocellular carcinoma DOID:684 y y PMID:22001310 addition of tert-butyl hydroquinone (t-BHQ) increased induction AAP 4000000305 Jodi P19838 4790 NFKB1 protein Homo sapiens 9606 yes NFkB P41222 5730 PTGDS gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 SH-SY5Y cell BTO:0000793 neuroblastoma DOID:769 y y PMID:22043816 binding enhanced by treatment of cells with paraquat AAP 4000000306 Jodi Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P41222 5730 PTGDS gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 SH-SY5Y cell BTO:0000793 neuroblastoma DOID:769 y y PMID:22043816 binding enhanced by treatment of cells with paraquat AAP 4000000307 Katie Q16665 3091 HIF1A protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 kidney cell line BTO:0000067 y y PMID:22068612 AAP 4000000308 Jodi P42226 6778 STAT6 protein Homo sapiens 9606 P16050 246 ALOX15 gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 Hodgkin's lymphoma DOID:8567 y y PMID:22094113 Hodgkin lymphoma L1236 cell line AAP 4000000309 Jodi P42226 6778 STAT6 protein Homo sapiens 9606 P16050 246 ALOX15 gene Homo sapiens 9606 antisense exeriment evidence ECO:0000018 regulation of gene expression GO:0010468 Hodgkin's lymphoma DOID:8567 y y PMID:22094113 STAT6 expression inhibited by siRNA, resulting in a decrease in ALOX15 mRNA; Hodgkin lymphoma L1236 cell line AAP 4000000310 Jodi Q92985 3665 IRF7 protein Homo sapiens 9606 Q9NS75 57105 CYSLTR2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 intestine-407 cell BTO:0000633 y y PMID:22194989 IRF7 protein provided by nuclear extract; binding competed by anti-IRF7 antibody; binding enhanced by treatment of cells with interferon alpha AAP 4000000311 Jodi O95863 6615 SNAI1 protein Homo sapiens 9606 Q9NS75 57105 CYSLTR2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 intestine-407 cell BTO:0000633 y y PMID:22194989 SNAI1 protein provided by nuclear extract; binding competed by anti-Snail antibody; binding enhanced by treatment of cells with epidermal growth factor (EGF) AAP 4000000312 Katie Q00613 3297 HSF1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 umbilical vein endothelium UBERON:0007777 umbilical vein endothelial cell line BTO:0001520 y y PMID:22347460 Heat shock induced COX-2 expression in various cell lines AAP 4000000313 Katie Q00613 3297 HSF1 protein Homo sapiens 9606 P35354 5743 PTGS2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 umbilical vein endothelium UBERON:0007777 umbilical vein endothelial cell line BTO:0001520 y y PMID:22347460 Heat shock induced COX-2 expression in various cell lines AAP 4000000314 Jodi P49716 1052 CEBPD protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:22381139 binding to upstream repressor region AAP 4000000315 Jodi P49716 1052 CEBPD protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 transcript expression level evidence ECO:0000048 negative regulation of gene expression GO:0010629 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:22381139 AAP 4000000316 Jodi P49716 1052 CEBPD protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:22381139 AAP 4000000317 Jodi P14859 5451 POU2F1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:22381139 PMA treatment for 16-24 hours enhances binding AAP 4000000318 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:22381139 PMA treatment for 16-24 hours enhances binding AAP 4000000319 Jodi P17947 6688 SPI1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:22381139 binding to upstream repressor region AAP 4000000320 Jodi P17947 6688 SPI1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:22381139 PMA treatment causes switch to SPI1 as the predominat factor binding the URR/PRR1 region of the promoter AAP 4000000321 Jodi P17947 6688 SPI1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 phorbol 13-acetate 12-myristate CHEBI:37537 y y PMID:22381139 PMA treatment for 16-24 hours enhances binding AAP 4000000322 Jodi P17947 6688 SPI1 protein Homo sapiens 9606 P43119 5739 PTGIR gene Homo sapiens 9606 transcript expression level evidence ECO:0000048 negative regulation of gene expression GO:0010629 HEL-92.1.7 cell BTO:0003320 leukemia DOID:1240 y y PMID:22381139 AAP 4000000323 Jodi P19838 4790 NFKB1 protein Homo sapiens 9606 O75828 874 CBR3 gene Homo sapiens 9606 transcript expression level evidence ECO:0000048 positive regulation of gene expression GO:0010628 HT-29 cell BTO:0000182 colon adenocarcinoma DOID:234 y y PMID:22425771 AAP 4000000324 Jodi Q04206 5970 RELA protein Homo sapiens 9606 O75828 874 CBR3 gene Homo sapiens 9606 transcript expression level evidence ECO:0000048 positive regulation of gene expression GO:0010628 HT-29 cell BTO:0000182 colon adenocarcinoma DOID:234 y y PMID:22425771 AAP 4000000325 Jodi P35869 196 AHR protein Homo sapiens 9606 P16152 873 CBR1 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 A-549 cell BTO:0000018 bronchiolo-alveolar adenocarcinoma DOID:4926 y y PMID:22531821 nuclear extracts treated with benzo-alpha-pyrene and incubated with anti-AhR antibody AAP 4000000326 Jodi P01100 2353 FOS protein Homo sapiens 9606 yes AP1 P16152 873 CBR1 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 U-937 cell BTO:0001412 non-Hodgkin lymphoma DOID:0060060 diarsenic trioxide CHEBI:30621 y y PMID:22719067 mutation of the binding site prevents elevated expression of a luciferase promoter construct treated with As2Oc AAP 4000000327 Jodi P05412 3725 JUN protein Homo sapiens 9606 yes AP1 P16152 873 CBR1 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 U-937 cell BTO:0001412 non-Hodgkin lymphoma DOID:0060060 diarsenic trioxide CHEBI:30621 y y PMID:22719067 mutation of the binding site prevents elevated expression of a luciferase promoter construct treated with As2Oc AAP 4000000328 Jodi P08670 7431 VIM protein Homo sapiens 9606 P16050 246 ALOX15 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 regulation of gene expression GO:0010468 BPH-1 cell BTO:0001323 y y PMID:22879973 ALOX15 promoter variant rs2255888 (associated with atherosclerosis) binds vimentin AAP 4000000329 Jodi P08670 7431 VIM protein Homo sapiens 9606 P16050 246 ALOX15 gene Homo sapiens 9606 chromatin immunoprecipitation-chip evidence ECO:0000230 direct interaction MI:0407 DNA binding GO:0003677 NIH-3T3 cell BTO:0000944 y y PMID:22879973 AAP 4000000330 Jodi P08670 7431 VIM protein Homo sapiens 9606 P16050 246 ALOX15 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 NIH-3T3 cell BTO:0000944 y y PMID:22879973 AAP 4000000331 Katie Q02447 6670 SP3 protein Homo sapiens 9606 P42330 8644 AKR1C3 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 y y PMID:22888320 Reporter assays determining that SP3 is important were done in transfected Drosophila cells, HepG2 cells were used to show basal promoter activity and induction by 5-DHT, also includes association study of promoter SNP with prostate cancer AAP 4000000332 Jodi P50219 3110 MNX1 gene Homo sapiens 9606 P43116 5732 PTGER2 gene Homo sapiens 9606 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 HL-60 cell BTO:0000738 acute myeloid leukemia DOID:9119 y y PMID:23048027 AAP 4000000333 Jodi P50219 3110 MNX1 gene Homo sapiens 9606 P43116 5732 PTGER2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 HL-60 cell BTO:0000738 acute myeloid leukemia DOID:9119 y y PMID:23048027 AAP 4000000334 Jodi Q16236 4780 NFE2L2 protein Homo sapiens 9606 Q924V2 100689020 Chcr2 gene Cricetulus griseus 10029 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 CHO-K1 cell BTO:0000457 sulforaphane CHEBI:47807 y y PMID:23247010 4000000335 Jodi Q16236 4780 NFE2L2 protein Homo sapiens 9606 Q924V3 100689019 Chcr1 gene Cricetulus griseus 10029 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 CHO-K1 cell BTO:0000457 sulforaphane CHEBI:47807 y y PMID:23247010 4000000336 Jodi Q16236 4780 NFE2L2 protein Homo sapiens 9606 P16152 873 CBR1 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 Hep-G2 cell BTO:0000599 hepatocellular carcinoma DOID:684 sulforaphane CHEBI:47807 y y PMID:23247010 NFE2L2 binds antioxidant responsive element ARE1 AAP 4000000337 Jodi Q16236 4780 NFE2L2 protein Homo sapiens 9606 P16152 873 CBR1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 Hep-G2 cell BTO:0000599 hepatocellular carcinoma DOID:684 y y PMID:23247010 AAP 4000000338 Chandra Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HMEC-1 cell BTO:0002828 y y PMID:8995303 AAP 4000000339 Chandra Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 regulation of gene expression GO:0010468 HMEC-1 cell BTO:0002828 y y PMID:8995303 AAP 4000000340 Chandra Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 umbilical vein endothelium UBERON:0007777 HUVEC cell BTO:0001949 y y PMID:8995303 AAP 4000000341 Chandra Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P35354 5743 PTGS2 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 umbilical vein endothelium UBERON:0007777 HUVEC cell BTO:0001949 y y PMID:8995303 AAP 4000000342 Chandra Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 umbilical vein endothelium UBERON:0007777 HUVEC cell BTO:0001949 y y PMID:8995303 AAP 4000000343 Chandra Q04206 5970 RELA protein Homo sapiens 9606 yes NFkB P35354 5743 PTGS2 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 regulation of gene expression GO:0010468 umbilical vein endothelium UBERON:0007777 HUVEC cell BTO:0001949 y y PMID:8995303 AAP 4000000344 Chandra P08047 6667 SP1 protein Homo sapiens 9606 no P23219 5742 PTGS1 gene Homo sapiens 9606 electrophoretic mobility shift assay evidence direct interaction MI:0407 DNA binding GO:0003677 umbilical vein endothelium UBERON:0007777 HUVEC cell BTO:0001949 y y PMID:9054382 SP1 isoforms primarily responsible for basal expression of COX1 expression AAP 4000000345 Chandra P08047 6667 SP1 protein Homo sapiens 9606 no P23219 5742 PTGS1 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 regulation of gene expression GO:0010468 umbilical vein endothelium UBERON:0007777 HUVEC cell BTO:0001949 y y PMID:9054382 COX1 promoter-luciferase assay AAP 4000000346 Jodi P10828 7068 THRB protein Homo sapiens 9606 P19793 6256 RXRA protein Homo sapiens 9606 P41222 5730 PTGDS gene Homo sapiens 9606 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 TE-671 cell BTO:0002605 embryonal rhabdomyosarcoma DOID:3246 y y PMID:9162076 interacts with the TRE (thyroid response element) in the PTGDS promoter; presence of RXRA enhances the interaction AAP 4000000347 Jodi P10828 7068 THRB protein Homo sapiens 9606 P22057 25526 PTGDS gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 TE-671 cell BTO:0002605 embryonal rhabdomyosarcoma DOID:3246 thyroid hormone CHEBI:60311 y y PMID:9162076 in the presence of thyroid hormone AAP 4000000348 Jodi P10828 7068 THRB protein Homo sapiens 9606 P41222 5730 PTGDS gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 TE-671 cell BTO:0002605 embryonal rhabdomyosarcoma DOID:3246 y y PMID:9162076 in the absence of thyroid hormone AAP 4000000349 Chandra P05627 16476 Jun protein Mus musculus 10090 yes AP1 P36423 21391 Tbxas1 gene Mus musculus 10090 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 CHO cell BTO:0000246 y y PMID:9367676 4000000350 Chandra O89090 20683 Sp1 protein Mus musculus 10090 no P36423 21391 Tbxas1 gene Mus musculus 10090 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 CHO cell BTO:0000246 y y PMID:9367676 4000000351 Chandra P05627 16476 Jun protein Mus musculus 10090 yes AP1 P36423 21391 Tbxas1 gene Mus musculus 10090 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 HL-60 cell BTO:0000738 acute myeloid leukemia DOID:9119 y y PMID:9367676 4000000352 Chandra O89090 20683 Sp1 protein Mus musculus 10090 no P36423 21391 Tbxas1 gene Mus musculus 10090 reporter gene assay evidence ECO:0000049 negative regulation of gene expression GO:0010629 HL-60 cell BTO:0000738 acute myeloid leukemia DOID:9119 y y PMID:9367676 4000000353 Jodi P10276 5914 RARA protein Homo sapiens 9606 yes RAR-RXR P19793 6256 RXRA protein Homo sapiens 9606 P22057 25526 Ptgds gene Rattus norvegicus 10116 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 COS-7 cell BTO:0000298 retinoic acid CHEBI:26536 y y PMID:9582446 assays done in COS-7 cells 4000000354 Jodi P19793 6256 RXRA protein Homo sapiens 9606 yes RAR-RXR P10276 5914 RARA protein Homo sapiens 9606 P22057 25526 Ptgds gene Rattus norvegicus 10116 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 COS-7 cell BTO:0000298 retinoic acid CHEBI:26536 y y PMID:9582446 assays done in COS-7 cells 4000000355 Jodi P19793 6256 RXRA protein Homo sapiens 9606 yes TR-RXR P10828 7068 THRB protein Homo sapiens 9606 P22057 25526 Ptgds gene Rattus norvegicus 10116 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 COS-7 cell BTO:0000298 thyroid hormone CHEBI:60311 y y PMID:9582446 assays done in COS-7 cells 4000000356 Jodi P10828 7068 THRB protein Homo sapiens 9606 yes TR-RXR P19793 6256 RXRA protein Homo sapiens 9606 P22057 25526 Ptgds gene Rattus norvegicus 10116 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 COS-7 cell BTO:0000298 thyroid hormone CHEBI:60311 y y PMID:9582446 assays done in COS-7 cells 4000000357 Jodi P10276 5914 RARA protein Homo sapiens 9606 yes RAR-RXR P19793 6256 RXRA protein Homo sapiens 9606 P22057 25526 Ptgds gene Rattus norvegicus 10116 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 y y PMID:9582446 4000000358 Jodi P19793 6256 RXRA protein Homo sapiens 9606 yes RAR-RXR P10276 5914 RARA protein Homo sapiens 9606 P22057 25526 Ptgds gene Rattus norvegicus 10116 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 y y PMID:9582446 4000000359 Jodi P19793 6256 RXRA protein Homo sapiens 9606 yes TR-RXR P10828 7068 THRB protein Homo sapiens 9606 P22057 25526 Ptgds gene Rattus norvegicus 10116 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 y y PMID:9582446 4000000360 Jodi P10828 7068 THRB protein Homo sapiens 9606 yes TR-RXR P19793 6256 RXRA protein Homo sapiens 9606 P22057 25526 Ptgds gene Rattus norvegicus 10116 electrophoretic mobility shift assay evidence ECO:0000096 direct interaction MI:0407 DNA binding GO:0003677 HeLa cell BTO:0000567 cervical adenocarcinoma DOID:3702 y y PMID:9582446 4000000361 Jodi P10828 7068 THRB protein Homo sapiens 9606 yes P19793 6256 RXRA protein Homo sapiens 9606 P22057 25526 Ptgds gene Rattus norvegicus 10116 chromatin immunoprecipitation evidence ECO:0000226 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:9582446 in vitro translated THRB and RXRA proteins used 4000000362 Jodi P18146 1958 EGR1 protein Homo sapiens 9606 P09917 240 ALOX5 gene Homo sapiens 9606 nucleic acid binding evidence ECO:0000136 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:9698605 DNase footprinting AAP 4000000363 Jodi P18146 1958 EGR1 protein Homo sapiens 9606 P09917 240 ALOX5 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 y y PMID:9698605 Drosophila SL2 cotransfection system AAP 4000000364 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P09917 240 ALOX5 gene Homo sapiens 9606 nucleic acid binding evidence ECO:0000136 direct interaction MI:0407 DNA binding GO:0003677 y y PMID:9698605 DNase footprinting AAP 4000000365 Jodi P08047 6667 SP1 protein Homo sapiens 9606 P09917 240 ALOX5 gene Homo sapiens 9606 reporter gene assay evidence ECO:0000049 positive regulation of gene expression GO:0010628 y y PMID:9698605 Drosophila SL2 cotransfection system AAP 4000000366