Human gene name human protein (UniProt ID) human protein (NCBI Gene ID) Mouse ortholog/analog (gene name|NCBI ID) Evidence code (mouse) Notes (mouse) Fish ortholog/analog (gene name|NCBI ID) Evidence code (fish) Notes (fish) Yeast ortholog/analog (standard name|ORF) Evidence code (yeast) Notes (yeast) Rat ortholog/analog (gene name|NCBI ID) Evidence code (rat) Notes (rat) ABCC1 P33527 4363 Abcc1|17250 1 abcc1|100002010 2 YCF1|YDR135C 6 There are 4 homologs in P-POD (which appear to be paralogs due to reciprocal loss), including the 2 analogs, but YCF1 has the better p-value. nd ABCC4 O15439 10257 Abcc4|239273 2 abcc4|368620 2 YOR1|YGR281W 2 nd ACAD9 Q9H845 28976 Acad9|229211 1 acad9|724002 1 none 7 nd ACAT1 P24752 38 Acat1|110446 1 acat1|445290 1 DGA1/YOR245C 9 PMID: 11751875 makes TAG from DAG along with LRO1/YNR008W nd ACOT1 Q86TX2 641371 Acot1|26897; Acot2|171210 6 Human ACOT1 and ACOT2 are close paralogs and share all the same orthologs. All four analogs have the same p-value. none 7 All fish proteins in P-POD are either fragments or have been deprecated. none 7 nd ACOT11 Q8WXI4 26027 Acot11|329910 1 acot11a|554842 2 none 7 nd ACOT13 Q9NPJ3 55856 Acot13|66834 1 acot13|564010 2 none 7 nd ACOT2 P49753 10965 Acot1|26897; Acot2|171210 6 Human ACOT1 and ACOT2 are close paralogs and share all the same orthologs. All four analogs have the same p-value. none 7 none 7 nd ACOT4 Q8N9L9 122970 Acot4|171282 1 none 7 No orthologs in OrthoMCL; all 3 MP orthologs are fragments or have been deprecated. none 7 nd ACOT7 O00154 11332 Acot7|70025 2 acot7|447878 2 none 7 nd ACOT8 O14734 10005 Acot8|170789 2 acot8|450052 2 TES1|YJR019C 2 Looks like a paralog due to reciprocal loss, but function and compartment match. nd ACSL1 P33121 2180 Acsl114081 1 acsl1b/Zgc:101071|445175;acsl1|555308 8 In IMP, zgc:101071 has a better p-value (4e-12) than fish acsl1 (9e-5). FAA1|YOR317W;FAA4|YMR246W 9 PMID: 22633490; functional complementation:human gene ACSL1 restored Sph-to-glycerolipid conversion to faa1 faa4 double mutant nd ACSL3 O95573 2181 Acsl3|74205 1 acsl3a|567157;acsl3b|559656 2 FAA1|YOR317W;FAA3|YIL009W 8 A third ortholog, FAA4, has a much weaker p-value. nd ACSL4 O60488 2182 Acsl4|50790 1 acsl4a|393622 1 FAA1|YOR317W;FAA3|YIL009W;FAA4|YMR246W 8, 9 A third ortholog, FAA4, has a much weaker p-value.; PMID:24269233 human gene ACSL4 complemented the deficient SPH-to-glycerophospholipid metabolism in Δfaa1 Δfaa4 cells nd ACSL5 Q9ULC5 51703 Acsl5|433256 1 none 7 There are fish genes in the same OrthoMCL family, but they are paralogous to ACSL5 and orthologous to other human genes. none 7, 9 The closest yeast gene, FAA2, is paralogous to ACSL5 and is a medium-, not a long-chain, synthase.; PMID:24269233 human gene ACSL5 complemented the deficient SPH-to-glycerophospholipid metabolism in Δfaa1 Δfaa4 cells nd ACSL6 Q9UKU0 23305 Acsl6|216739 1 acsl6|566863 2 FAA1|YOR317W;FAA4|YMR246W 9 PMID: 22633490; functional complementation:human gene ACSL6 restored Sph-to-glycerolipid conversion to faa1 faa4 double mutant nd AGPAT2 O15120 10555 Agpat2|67512 1 none 7 none 7 nd AGPAT4 Q9NRZ5 56895 Agpat4|68262 1 agpat4|406265 2 none 7 nd AGPAT5 Q9NUQ2 55326 Agpat5|52123 1 agpat5|767778 2 none 7 nd AKR1B1 P15121 231 Akr1B3|11677 1 akr1b1|415138 1 Also orthologous to hAKR1B10. none 7 nd AKR1C3 P42330 8644 Akr1c6|83702 6 IMP identified 3 different proteins with p=1e-3. none 7 none 7 nd ALOX12 P18054 239 Alox12|11684 1 Mouse has several other genes with similar names, but this one is the ortholog/analog. alox12|322732 1 Zebrafish alox12 is orthologous to hALOX12 and hALOX15. none 7 Alox12|287454 1 ALOX12B O75342 242 Alox12b|11686 2 none 7 Closest zebrafish genes are paralogous to ALOX12B and more closely related to LOX5. none 7 Alox12b|287425 1 ALOX15 P16050 246 Alox15/Alox12l|11687 2 alox12|322732 2 Zebrafish alox12 is orthologous to hALOX12 and hALOX15. none 7 Alox15|81639 1 ALOX15B O15296 247 Alox8|11688 1 none 7 none 7 Alox15b|266604 1 ALOX5 P09917 240 Alox5|11689 1 alox5|567204 2 none 7 Alox5|25290 1 ALOX5AP P20292 241 Alox5ap|11690 1 alox5ap|337376 2 none 7 Alox5ap|29624 1 ALOXE3 Q9BYJ1 59344 Aloxe3|23801 1 none 7 Closest zebrafish genes in P-POD correspond to hALOX5. none 7 nd AWAT2 Q6E213 158835 Awat2|245532 1 none 7 none 7 nd BAAT Q14032 570 Baat|12012 1 none 7 none 7 nd CBR1 P16152 873 Cbr1|12408 2 cbr1|373866;cbr1l|337696 2 Zebrafish cbr1 and cbr1l are orthologous to both human CBR1 and CBR3. A third ortholog listed in P-POD has been deprecated. none 7 nd CBR3 O75828 874 Cbr3|109857 1 cbr1|373866;cbr1l|337696 2 Zebrafish cbr1 and cbr1l are orthologous to both human CBR1 and CBR3. A third ortholog listed in P-POD has been deprecated. none 7 nd CYP1A1 P04798 1543 Cyp1a1|13076 1 cyp1a|140634 1 Difficult to classify Cyp450 proteins. Zebrafish cyp1a is the closest paralog and the only IMP analog of human CYP1A1. Also, there appears to be a reciprocal loss in that clade of the OrthoMCL family, resulting in a presumptive duplication event with bird and fish genes forming one clade and mammalian genes another; if this reciprocal loss is not correct, then cyp1a would be an ortholog of CYP1A1. none 7 nd CYP1A2 P05177 1544 Cyp1a2|13077 1 cyp1a|140634 1 Difficult to classify Cyp450 proteins. Zebrafish cyp1a is paralogous to human CYP1A1 and CYP1A2. none 7 nd CYP1B1 Q16678 1545 Cyp1b1|13078 1 cyp1b1|100150054 1 none 7 nd CYP2B6 P20813 1555 Cyp2b19|13090;Cyp2b9|13094 5 Difficult to classify Cyp450 proteins. Both P-POD and IMP agree on these five mouse genes: Cyp2b19 (NCBI GeneID 13090; p=5e-12), Cyp2b9 (NCBI GeneID 13094; p=3e-12), Cyp2b10 (NCBI GeneID 13088; p=2e-06), Cyp2b23 (NCBI GeneID 243881; p=6e-4), and Cyp2b13 (NCBI GeneID 13089; p=2e-3). none 7 Difficult to classify Cyp450 proteins. none 7 nd CYP2C18 P33260 1562 Cyp2c55|72082 2 Difficult to classify Cyp450 proteins. cyp2y3|368352 2 Difficult to classify Cyp450 proteins. Zebrafish cyp2y3 is orthologous to human CYP2C8, CYP2C9, CYP2C18, and CYP2C19. none 7 nd CYP2C19 P33261 1557 Cyp2c66|69888;Cyp2c65|72303 3 Difficult to classify Cyp450 proteins. cyp2y3|368352 2 Difficult to classify Cyp450 proteins. Zebrafish cyp2y3 is orthologous to human CYP2C8, CYP2C9, CYP2C18, and CYP2C19. none 7 nd CYP2C8 P10632 1558 Cyp2c55|72082 3 Difficult to classify Cyp450 proteins. cyp2y3|368352 2 Difficult to classify Cyp450 proteins. Zebrafish cyp2y3 is orthologous to human CYP2C8, CYP2C9, CYP2C18, and CYP2C19. none 7 nd CYP2C9 P11712 1559 Cyp2c66|69888;Cyp2c65|72303 3 Difficult to classify Cyp450 proteins. cyp2y3|368352 2 Difficult to classify Cyp450 proteins. Zebrafish cyp2y3 is orthologous to human CYP2C8, CYP2C9, CYP2C18, and CYP2C19. none 7 nd CYP2D6 P10635 1565 Cyp2d26|76279 5 Difficult to classify Cyp450 proteins. Mouse Cyp2d26 is the top-ranked analog (p=1e-11) and a close paralog of human CYP2D6. Other analogs include Cyp2d26 (NCBI GeneID 76279; p=1e-11), Cyp2d12 (NCBI GeneID 380997; p=4e-7), Cyp2d22 (NCBI GeneID 56448; p=4e-7), Cyp2d34 (NCBI GeneID 223706; p=4e-7), and Cyp2d40 (NCBI GeneID 71754; p=4e-7). P-POD names Cyp2d22 as the ortholog of CYP2D6. none 7 Difficult to classify Cyp450 proteins. none 7 nd CYP2E1 P05181 1571 Cyp2e1|13106 1 none 7 none 7 nd CYP2J2 P51589 1573 Cyp2j6 |13110 5 Difficult to classify Cyp450 proteins. Top-ranked analog (also an ortholog): Cyp2j6 (NCBI GeneID 13110; p=8e-10). Other analogs and orthologs identified include: Cyp2j5 (NCBI GeneID 13109; p=1e-4), Cyp2j9 (NCBI GeneID 74519; p=9e-4), Cyp2j11 (NCBI GeneID 100066; p=9e-4), Cyp2j13 (NCBI GeneID 230459), Cyp2j8 (NCBI GeneID 665095), and Cyp2j12 (NCBI GeneID 242546). cyp2n13|492484;cyp2p6|393108;cyp2p10|399485;cyp2p9|393592;cyp2v1|494153;cyp2ae1|572114;cyp2j20|797309;cyp2p7|100034406;cyp2p8|100034366 6 Difficult to classify Cyp450 proteins. There appears to have been rapid expansion of this gene in zebrafish; P-POD (OrthoMCL) lists 8 orthologs, which form a single clade of fish proteins. Four of these proteins (cyp2n13, cyp2p6, cyp2p10, and cyp2p9) are also listed as analogs in IMP. IMP also identifies a fifth, slightly weaker, analog, cyp2v1; this gene is orphaned in P-POD's OrthoMCL analysis, but identified as an ortholog of hCYP2J2 in P-POD's MultiParanoid analysis. Because the genes are so closely related, and because the analogs have comparable p-values, I am choosing the combined set of all nine proteins. none 7 nd CYP2U1 Q7Z449 113612 Cyp2u1|71519 3 Difficult to classify Cyp450 proteins. cyp2u1|556280 2 Difficult to classify Cyp450 proteins. none 7 nd CYP3A4 P08684 1576 Cyp3a11|13112;Cyp3a25|56388;Cyp3a41b|100041375;Cyp3a16|13114;Cyp3a59|100041449 5 Difficult to classify Cyp450 proteins. P-POD and IMP agree on the top five hits: Cyp3a11 (NCBI GeneID 13112; p=5e-12), Cyp3a25 (NCBI GeneID 56388; p=5e-12), Cyp3a41b (NCBI GeneID 100041375; p=6e-12), Cyp3a16 (NCBI GeneID 13114; p=2e-11), and Cyp3a59 (NCBI GeneID 100041449; p=7e-10). Four additional proteins are identified as either orthologs or analogs: Cyp3a57 (NCBI GeneID 622127), Cyp3a13 (NCBI GeneID 13113), Cyp3a41a (NCBI GeneID 53973), and Cyp3a44 (NCBI GeneID 337924). cyp3c1l2|492759;cyp3c4|558541 6 Difficult to classify Cyp450 proteins. P-POD identified one ortholog, cyp3a65 (NCBI GeneID 553969), which was the third-ranked of the 4 analogs identified by IMP: cyp3c1l2 (NCBI GeneID 492759; p=1e-6); cyp3c4 (NCBI GeneID 558541; p=3e-6); cyp3a65 (NCBI GeneID 553969; p=7e-5); cyp3c1 (NCBI GeneID 324340; p=4e-4). Curator chose the two top-ranked analogs. none 7 nd CYP4A11 Q02928 1579 Cyp4a10|13117;Cyp4a31|666168;Cyp4a32|100040843 (9e-4) 5 Difficult to classify Cyp450 proteins. IMP identifies these three mouse proteins as the best analogs: Cyp4a10 (NCBI GeneID 13117; p=1e-05), Cyp4a31 (NCBI GeneID 666168; p=9e-4), and Cyp4a32 (NCBI GeneID 100040843; p=9e-4). P-POD also identifies the following as orthologs: Cyp4a12a (NCBI GeneID 277753), Cyp4a12b (NCBI GeneID 13118), Cyp4a14 (NCBI GeneID 13119), and pseudogene Cyp4a30b-ps (NCBI GeneID 435802). cyp4t8|387527 2 Difficult to classify Cyp450 proteins. Zebrafish cyp4t8 is also orthologous to several other human CYP450 proteins. none 7 Cyp4a1|50549 2 Difficult to classify Cyp450 proteins. P-POD also identifies multiple orthologs. CYP4A22 Q5TCH4 284541 Cyp4a31|666168;Cyp4a32|100040843;Cyp4a10|13117 5 Difficult to classify Cyp450 proteins. IMP identifies these three mouse proteins as the best analogs: Cyp4a31 (NCBI GeneID 666168; p=3e-4), Cyp4a32 (NCBI GeneID 100040843; p=3e-4), and Cyp4a10 (NCBI GeneID 13117; p=3e-3). P-POD also identifies the following as orthologs: Cyp4a12a (NCBI GeneID 277753), Cyp4a12b (NCBI GeneID 13118), Cyp4a14 (NCBI GeneID 13119), and pseudogene Cyp4a30b-ps (NCBI GeneID 435802). cyp4t8|387527 2 Difficult to classify Cyp450 proteins. Zebrafish cyp4t8 is also orthologous to several other human CYP450 proteins. none 7 nd CYP4F11 Q9HBI6 57834 Cyp4f15|106648;Cyp4f40|631304 2 Difficult to classify Cyp450 proteins. These mouse proteins are orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. cyp4f43|100037390 2 Difficult to classify Cyp450 proteins. This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. none 7 nd CYP4F2 P78329 8529 Cyp4f15|106648;Cyp4f40|631304 2 Difficult to classify Cyp450 proteins. These mouse proteins are orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. cyp4f3|100037390 2 Difficult to classify Cyp450 proteins. This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. none 7 nd CYP4F22 Q6NT55 126410 Cyp4f39|320997 1 cyp4f43|100037390 2 Difficult to classify Cyp450 proteins. This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. none 7 nd CYP4F3 Q08477 4051 Cyp4f15|106648;Cyp4f40|631304 2 Difficult to classify Cyp450 proteins. These mouse proteins are orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. cyp4f3|100037390 2 Difficult to classify Cyp450 proteins. This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. none 7 nd CYP4F8 P98187 11283 Cyp4f15|106648;Cyp4f40|631304 2 Difficult to classify Cyp450 proteins. These mouse proteins are orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. cyp4f3|100037390 2 Difficult to classify Cyp450 proteins. This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11. none 7 nd CYSLTR1 Q9Y271 10800 Cysltr1|58861 1 cysltr1|553675 1 none 7 Cysltr1|114099 1 CYSLTR2 Q9NS75 57105 Cysltr2|70086 1 none 7 none 7 nd DPEP1 P16444 1800 Dpep1|13479 2 dpep1/zgc:153024|768195 2 none 7 nd DPEP2 Q9H4A9 64174 Dpep2|319446 4 Human DPEP2 is paralogous to both mouse Dpep2 and Dpep3. none 7 none 7 nd ELOVL2 Q9NXB9 54898 Elovl2|54326 1 elovl2|678614 1 none 7 No orthologs in OrthoMCL; all 3 MultiParanoid homologs are paralogs and orthologous to other human proteins. nd ELOVL5 Q9NYP7 60481 Elovl5|68801 1 elovl5|393425 2 none 7 No orthologs in OrthoMCL; all 3 MultiParanoid homologs are paralogs and orthologous to other human proteins. nd EPHX2 P34913 2053 Ephx2|13850 2 ephx2|494099 2 P-POD shows a duplication and reciprocal loss among the vertebrates--chicken and zebrafish are in one clade and human, mouse, and rat are in the other--but that may be incorrect. As a result, zebrafish ephx2, which P-POD shows as paralogous to hEPHX2, may actually be orthologous. YNR064C 9 PMID: 15769598; YNRO64C is homologous to the epoxide hydrolase portion of the mammalian EPHX2, the homology to the lipid phosphatase (lipase) function has not been investigated nd FADS1 O60427 3992 Fads1|76267 3 Protein not in P-POD. none 7 Protein not in P-POD. none 7 Human protein not present in P-POD input nd FADS2 O95864 9415 Fads2|56473 1 fads2|140615 1 none 7 nd FAM213B/C1ORF93 Q8TBF2 127281 Fam213b/2810405K02RIK|66469 1 fam213b|406605 2 none 7 nd GGT1 P19440 2678 Ggt1|14598 2 ggt1a|393387;ggt1b|569014 2 ECM38|YLR299W 2 nd GGT5 P36269 2687 Ggt5|23887 2 none 7 none 7 nd GGT6 Q6P531 124975 Ggt6|71522 1P none 7 none 7 nd GGT7 Q9UJ14 2686 Ggt7|207182 1 none 7 none 7 nd GPR17 Q13304 2840 Gpr17|574402 1 none 7 P-POD hit not a verified gene. none 7 nd GPX1 P07203 2876 Gpx1|14775 2 gpx1a|352926 2 none 7 nd GPX2 P18283 2877 Gpx2|14776 2 none 7 none 7 nd GPX3 P22352 2878 Gpx3|14778 1 gpx3|798788 2 none 7 nd GPX4 P36969 2879 Gpx4|625249 1 gpx4a|352928 2 none 7 Yeast genes are distantly related and paralogs. nd GPX5 O75715 2880 Gpx5|14780 2 none 7 none 7 nd GPX6 P59796 257202 Gpx6|75512 5 Human GPX6 is shown as paralogous to both mouse Gpx6 and Gpx5, but Gpx5 is orthologous to human GPX5. none 7 none 7 nd GPX7 Q96SL4 2882 Gpx7|67305 1 gpx7|552981 2 none 7 nd HPGD P15428 3248 Hpgd|15446 1 LOC565975|565975 2 none 7 nd HPGDS O60760 27306 Hpgds|54486 2 none 7 none 7 Hgpds|58962 1 LCAT P04180 3931 Lcat|16816 1 lcat|793137 2 LRO1/YNR008W 9 PMID: 10747858 makes TAG from DAG along with DGA1/YOR245C nd LIPA P38571 3988 Lipa|16889 1 lipf|406713 2 Lipf is orthologous to 2 clades of mammalian genes. YEH1|YLL012W; YEH2|YLR020C; TGL1|YKL140W 9 PMID: 15713625 de-esterify sterol esters nd LIPE Q05469 3991 Lipe|16890 2 lipea|568368 2 none 7 nd LIPG Q9Y5X9 9388 Lipg|16891 1 lipg|393096 2 none 7 nd LPCAT1 Q8NF37 79888 Lpcat1|210992 1 lpcat1|555969 1 none 7 nd LPCAT2 Q7L5N7 54947 Lpcat2|270084 1 lpcat2|553683 1 P-POD identifies lpcat2 as a paralog of hLPCAT2. none 7 nd LPCAT3 Q6P1A2 10162 Lpcat3|14792 1 none 7 none 7 nd LTA4H P09960 4048 Lta4h|16993 1 lta4h|406575 1 none 7 Limited biochemical similarity to paralog LAP2/YNL045W. Lta4h|299732 1 LTB4R Q15722 1241 Ltb4r1|16995 1 si:ch211-272h9.2|100317356;LOC100329657|100329657 2 none 7 Ltb4r|59264 1 LTB4R2 Q9NPC1 56413 Ltb4r2|57260 1 none 7 none 7 Ltb4r2|114098 1 LTC4S Q16873 4056 Ltc4s|17001 2 ltc4s|100535432 2 none 7 Ltc4s|114097 1 MAPKAPK2 P49137 9261 Mapkapk2|17164 1 mapkapk2a|327321 1 none 7 nd MBOAT7 Q96N66 79143 Mboat7|77582 1 mboat7|393509 1 none 7 nd MGST2 Q99735 4258 Mgst2 |211666 1 mgst2|723997 2 none 7 nd MGST3 O14880 4259 Mgst3|66447 2 mgst3|406736 1 Another ortholog has been deprecated. none 7 nd OXER1 Q8TDS5 165140 none 1 none 1 none 1 nd PAFAH2 Q99487 5051 Pafah2|100163 1 none 7 none 7 nd PLA2G10 O15496 8399 Pla2g10|26565 2 none 7 none 7 nd PLA2G12A Q9BZM1 81579 Pla2g12a|66350 2 pla2g12a|402802 2 none 7 nd PLA2G12B Q9BX93 84647 Pla2g12b|69836 1P pla2g12b|406739 2P none 7 nd PLA2G16 P53816 11145 Pla2g16|225845 2 none 7 There is 1 MultiParanoid ortholog, but it has been deprecated. none 7 nd PLA2G1B P04054 5319 Pla2g1b|18778 2 pla2g1b|571738 2 none 7 nd PLA2G2A P14555 5320 Pla2g2a|18780 2 none 7 none 7 Pla2g2a|29692 1 PLA2G2D Q9UNK4 26279 Pla2g2d|18782 1 none 7 none 7 nd PLA2G2E Q9NZK7 30814 Pla2g2e|26970 1 none 7 none 7 nd PLA2G2F Q9BZM2 64600 Pla2g2f|26971 1 none 7 none 7 nd PLA2G3 Q9NZ20 50487 Pla2g3|237625 2 zgc:123275|641423 2 none 7 nd PLA2G4A P47712 5321 Pla2g4a|18783 1 pla2g4a|559087;cpla2|30554 2 none 7 Pla2g4a|24653 1 PLA2G4B P0C869 100137049 Pla2g4b|211429 1 LOC565386|565386 2 LOC565386 is uncharacterized and is orthologous to several paralogous mammalian clades. none 7 nd PLA2G4C Q9UP65 8605 Pla2g4c|232889 1 zgc:101699|492789 2 P-POD lists 3 more fish orthologs with ENSEMBL IDs, but they don't map to Gene IDs. none 7 nd PLA2G4D Q86XP0 283748 Pla2g4d|78390 1 LOC565386|565386 2 LOC565386 is uncharacterized and is orthologous to several paralogous mammalian clades. none 7 nd PLA2G4E Q3MJ16 123745 Pla2g4e|329502 1 LOC565386|565386 2 LOC565386 is uncharacterized and is orthologous to several paralogous mammalian clades. none 7 nd PLA2G4F Q68DD2 255189 Pla2g4f|271844 1 LOC565386|565386 2 LOC565386 is uncharacterized and is orthologous to several paralogous mammalian clades. none 7 nd PLA2G5 P39877 5322 Pla2g5|18784 2 none 7 none 7 nd PLA2G6 O60733 8398 Pla2g6|53357 1 pla2g6|406370 2 none 7 nd PLB1 Q6P1J6 151056 Plb1|665270 2 none 7 PLB1|YMR008C; PLB2|YMR006C; PLB3|YOL011W 9 PMID: 10497163 nd PNPLA2 Q96AD5 57104 Pnpla2|66853 1 pnpla3|436610 2 Unreviewed protein. none 7 nd PTGDR Q13258 5729 Ptgdr|19214 1 none 7 none 7 nd PTGDR2/GPR44 Q9Y5Y4 11251 Gpr44|14764 1 none 7 One ortholog has been removed from Ensembl. none 7 nd PTGDS P41222 5730 Ptgds|19215 1 ptgdsa|555483;ptgdsb|336492 6 P-POD identifies 3 orthologs: ptgsb plus 2 predicted or provisional genes. IMP identifies ptgsa and -b, but ptgsa has a better p-value. none 7 Ptgds|25526 1 PTGER1 P34995 5731 Ptger1|19216 1 none 7 none 7 nd PTGER2 P43116 5732 Ptger2|19217 1 ptger2a|393608 6 P-POD also identifies ptger2b (NCBI GeneID 570410) as an ortholog of hPTGER2. none 7 nd PTGER3 P43115 5733 Ptger3|19218 1 ptger3|100000544 2 none 7 nd PTGER4 P35408 5734 Ptger4|19219 1 ptger4a|562469;ptger4b|100005416 8 none 7 nd PTGES O14684 9536 Ptges|64292 1 ptges|544666 1 none 7 Ptges|59103 1 PTGES2 Q9H7Z7 80142 Ptges2|96979 1 ptgesl|799964 2 none 7 nd PTGES3 Q15185 10728 Ptges3|56351 1 P-POD identifies an additional mouse pseudogene. UniProt identifier for Ptges3 maps to 3 NCBI Gene IDs, but 2 are deprecated or pseudogenes. ptges3a|406449 1 none 7, 9 ortholog SBA1 shares chaperone activity with PTGES3 but is not a prostaglandin synthase; PMID: 9584173 functional complementation: human gene PTGES3 complemented a yeast sba1 mutation for chaperone activity in vivo nd PTGFR P43088 5737 Ptgfr|19220 1 ptgfr|571808 2 A second locus, LOC100005681, is possibly a duplicate of ptgfr; it is also nearby. none 7 nd PTGIR P43119 5739 Ptgir|19222 1 ptgir|561406 2 none 7 Ptgis|25527 1 PTGIS Q16647 5740 Ptgis|19223 1 ptgis|559148 2 none 7 nd PTGR1 Q14914 22949 Ptgr1|67103 2 ptgr1|494108 1 none 7 The closest yeast gene is a paralog that is orthologous to another human gene. nd PTGS1 P23219 5742 Ptgs1|19224 1 ptgs1|246226 1 none 7 Ptgs1|24693 1 PTGS2 P35354 5743 Ptgs2|19225 1 ptgs2a|246227 8 Both P-POD and IMP identify both ptgs2a (NCBI GeneID 246227) and ptgs2b (NCBI GeneID 559020), but ptgs2a has a much better p-value in IMP. none 7 Ptgs2|29527 1 SLC27A2 O14975 11001 Slc27a2|26458 1 slc27a2|449925;slc27a2b|100004228 6 IMP identifes slc27a2, but the p-value is not very strong (3e-3). P-POD identifies slc27a2b plus 2 other predicted/provisional proteins. FAT1|YBR041W;FAA1|YOR317W;FAA4|YMR246W 3,9 PMID:24269233 human gene SLC27A2 complemented the deficient SPH-to-glycerophospholipid metabolism in Δfaa1 Δfaa4 cells nd SOAT1 P35610 6646 Soat1|20652 1 soat1|564424 2 ARE1/YCR048W; ARE2/YNR019W 9 PMID: 8798656; sterol esterification nd TBXA2R P21731 6915 Tbxa2r|21390 1 none 7 One ortholog in P-POD has been deprecated. none 7 nd TBXAS1 P24557 6916 Tbxas1|21391 1 tbxas1|792041 1 none 7 Tbxas1|24886 1