Human gene name	human protein (UniProt ID)	human protein (NCBI Gene ID)	Mouse ortholog/analog (gene name|NCBI ID)	Evidence code (mouse)	Notes (mouse)	Fish ortholog/analog (gene name|NCBI ID)	Evidence code (fish)	Notes (fish)	Yeast ortholog/analog (standard name|ORF)	Evidence code (yeast)	Notes (yeast)
ACAD9	Q9H845	28976	ACAD9|229211	1		acad9|724002	1		none	7	
ACAT1	P24752	38	ACAT1|110446	1		ACAT1|445290	1		none	6	The closest yeast gene, ERG10, is a paralog and has a poor p-value.
ACSL1	P33121	2180	ACSL1|14081	1		Zgc:101071|445175;acsl1|555308	8	In IMP, zgc:101071 has a better p-value (4e-12) than fish acsl1 (9e-5).  	none	7	A paralog, yeast FAA2, prefers medium chain fatty acids (vs. long-chain for ACSL1).
ACSL3	O95573	2181	ACSL3|74205	1		acsl3a|567157;acsl3b|559656	2		FAA1|YOR317W;FAA3|YIL009W	8	A third ortholog, FAA4, has a much weaker p-value.
ACSL4	O60488	2182	ACSL4|50790	1		acsl4a|393622	1		FAA1|YOR317W;FAA3|YIL009W	8	A third ortholog, FAA4, has a much weaker p-value.
ACSL5	Q9ULC5	51703	ACSL5|433256	1		none	7	There are fish genes in the same OrthoMCL family, but they are paralogous to ACSL5 and orthologous to other human genes.	none	7	The closest yeast gene, FAA2, is paralogous to ACSL5 and is a medium-, not a long-chain, synthase.
AGPAT2	O15120	10555	AGPAT2|67512	1		none	7		none	7	
AGPAT4	Q9NRZ5	56895	AGPAT4|68262	1		agpat4|406265	2		none	7	
AGPAT5	Q9NUQ2	55326	AGPAT5|52123	1		agpat5|767778	2		none	7	
AKR1B1	P15121	231	AKR1B3|11677	1		akr1b1|415138	1	Also orthologous to hAKR1B10.	none	7	
AKR1C3	P42330	8644	Akr1c6|83702	6	IMP identified 3 different proteins with p=1e-3.	none	7		none	7	
ALOX12	P18054	239	ALOX12|11684	1	Mouse has several other genes with similar names, but this one is the ortholog/analog.	alox12|322732	1	Zebrafish alox12 is orthologous to hALOX12 and hALOX15.	none	7	
ALOX12B	O75342	242	Alox12b|11686	2		none	7	Closest zebrafish genes are paralogous to ALOX12B and more closely related to LOX5.	none	7	
ALOX15	P16050	246	Alox12l|11687	2		alox12|322732	2	Zebrafish alox12 is orthologous to hALOX12 and hALOX15.	none	7	
ALOX15B	O15296	247	ALOX8|11688	1		none	7		none	7	
ALOX5	P09917	240	ALOX5|11689	1		alox5|567204	2		none	7	
ALOX5AP	P20292	241	ALOX5AP|11690	1		alox5ap|337376	2		none	7	
ALOXE3	Q9BYJ1	59344	ALOXE3|23801	1		none	7	Closest zebrafish genes in P-POD correspond to hALOX5.	none	7	
AWAT2	Q6E213	158835	AWAT2|245532	1		none	7		none	7	
C1ORF93	Q8TBF2	127281	2810405K02RIK|66469	1		fam213b|406605	2		none	7	
CBR1	P16152	873	Cbr1|12408	2		cbr1|373866;cbr1l|337696	2	Zebrafish cbr1 and cbr1l are orthologous to both human CBR1 and CBR3.  A third ortholog listed in P-POD has been deprecated.	none	7	
CBR3	O75828	874	CBR3|109857	1		cbr1|373866;cbr1l|337696	2	Zebrafish cbr1 and cbr1l are orthologous to both human CBR1 and CBR3.  A third ortholog listed in P-POD has been deprecated.	none	7	
CYP1A1	P04798	1543	CYP1A1|13076	1		cyp1a|140634	1	Difficult to classify Cyp450 proteins.  Zebrafish cyp1a is the closest paralog and the only IMP analog of human CYP1A1.  Also, there appears to be a reciprocal loss in that clade of the OrthoMCL family, resulting in a presumptive duplication event with bird and fish genes forming one clade and mammalian genes another; if this reciprocal loss is not correct, then cyp1a would be an ortholog of CYP1A1.	none	7	
CYP1A2	P05177	1544	CYP1A2|13077	1		cyp1a|140634	1	Difficult to classify Cyp450 proteins.  Zebrafish cyp1a is paralogous to human CYP1A1 and CYP1A2.	none	7	
CYP1B1	Q16678	1545	CYP1B1|13078	1		cyp1b1|100150054	1		none	7	
CYP2B6	P20813	1555	Cyp2b19|13090;Cyp2b9|13094	5	Difficult to classify Cyp450 proteins.  Both P-POD and IMP agree on these five mouse genes: Cyp2b19 (NCBI GeneID 13090; p=5e-12), Cyp2b9 (NCBI GeneID 13094; p=3e-12), Cyp2b10 (NCBI GeneID 13088; p=2e-06), Cyp2b23 (NCBI GeneID 243881; p=6e-4), and Cyp2b13 (NCBI GeneID 13089; p=2e-3).	none	7	Difficult to classify Cyp450 proteins.	none	7	
CYP2C18	P33260	1562	Cyp2c55|72082	2	Difficult to classify Cyp450 proteins.	cyp2y3|368352	2	Difficult to classify Cyp450 proteins.  Zebrafish cyp2y3 is orthologous to human CYP2C8, CYP2C9, CYP2C18, and CYP2C19.	none	7	
CYP2C19	P33261	1557	Cyp2c66|69888;Cyp2c65|72303	3	Difficult to classify Cyp450 proteins.	cyp2y3|368352	2	Difficult to classify Cyp450 proteins.  Zebrafish cyp2y3 is orthologous to human CYP2C8, CYP2C9, CYP2C18, and CYP2C19.	none	7	
CYP2C8	P10632	1558	Cyp2C55|72082	3	Difficult to classify Cyp450 proteins.	cyp2y3|368352	2	Difficult to classify Cyp450 proteins.  Zebrafish cyp2y3 is orthologous to human CYP2C8, CYP2C9, CYP2C18, and CYP2C19.	none	7	
CYP2C9	P11712	1559	Cyp2c66|69888;Cyp2c65|72303	3	Difficult to classify Cyp450 proteins.	cyp2y3|368352	2	Difficult to classify Cyp450 proteins.  Zebrafish cyp2y3 is orthologous to human CYP2C8, CYP2C9, CYP2C18, and CYP2C19.	none	7	
CYP2D6	P10635	1565	Cyp2d26|76279	5	Difficult to classify Cyp450 proteins.  Mouse Cyp2d26 is the top-ranked analog (p=1e-11) and a close paralog of human CYP2D6.  Other analogs include Cyp2d26 (NCBI GeneID 76279; p=1e-11), Cyp2d12 (NCBI GeneID 380997; p=4e-7), Cyp2d22 (NCBI GeneID 56448; p=4e-7), Cyp2d34 (NCBI GeneID 223706; p=4e-7), and Cyp2d40 (NCBI GeneID 71754; p=4e-7).  P-POD names Cyp2d22 as the ortholog of CYP2D6.	none	7	Difficult to classify Cyp450 proteins.	none	7	
CYP2E1	P05181	1571	CYP2E1|13106	1		none	7		none	7	
CYP2J2	P51589	1573	Cyp2j6 |13110	5	Difficult to classify Cyp450 proteins.  Top-ranked analog (also an ortholog): Cyp2j6 (NCBI GeneID 13110; p=8e-10).  Other analogs and orthologs identified include: Cyp2j5 (NCBI GeneID 13109; p=1e-4), Cyp2j9 (NCBI GeneID 74519; p=9e-4), Cyp2j11 (NCBI GeneID 100066; p=9e-4), Cyp2j13 (NCBI GeneID 230459), Cyp2j8 (NCBI GeneID 665095), and Cyp2j12 (NCBI GeneID 242546).	cyp2n13|492484;cyp2p6|393108;cyp2p10|399485;cyp2p9|393592;cyp2v1|494153;cyp2ae1|572114;cyp2j20|797309;cyp2p7|100034406;cyp2p8|100034366	6	Difficult to classify Cyp450 proteins.  There appears to have been rapid expansion of this gene in zebrafish; P-POD (OrthoMCL) lists 8 orthologs, which form a single clade of fish proteins.  Four of these proteins (cyp2n13, cyp2p6, cyp2p10, and cyp2p9) are also listed as analogs in IMP.  IMP also identifies a fifth, slightly weaker, analog, cyp2v1; this gene is orphaned in P-POD's OrthoMCL analysis, but identified as an ortholog of hCYP2J2 in P-POD's MultiParanoid analysis.  Because the genes are so closely related, and because the analogs have comparable p-values, I am choosing the combined set of all nine proteins.	none	7	
CYP2U1	Q7Z449	113612	CYP2U1|71519	3	Difficult to classify Cyp450 proteins.	cyp2u1|556280	2	Difficult to classify Cyp450 proteins.	none	7	
CYP3A4	P08684	1576	Cyp3a11|13112;Cyp3a25|56388;Cyp3a41b|100041375;Cyp3a16|13114;Cyp3a59|100041449	5	Difficult to classify Cyp450 proteins.  P-POD and IMP agree on the top five hits: Cyp3a11 (NCBI GeneID 13112; p=5e-12), Cyp3a25 (NCBI GeneID 56388; p=5e-12), Cyp3a41b (NCBI GeneID 100041375; p=6e-12), Cyp3a16 (NCBI GeneID 13114; p=2e-11), and Cyp3a59 (NCBI GeneID 100041449; p=7e-10).  Four additional proteins are identified as either orthologs or analogs: Cyp3a57 (NCBI GeneID 622127), Cyp3a13 (NCBI GeneID 13113), Cyp3a41a (NCBI GeneID 53973), and Cyp3a44 (NCBI GeneID 337924).	cyp3c1l2|492759;cyp3c4|558541	6	Difficult to classify Cyp450 proteins.  P-POD identified one ortholog, cyp3a65 (NCBI GeneID 553969), which was the third-ranked of the 4 analogs identified by IMP: cyp3c1l2 (NCBI GeneID 492759; p=1e-6); cyp3c4 (NCBI GeneID 558541; p=3e-6); cyp3a65 (NCBI GeneID 553969; p=7e-5); cyp3c1 (NCBI GeneID 324340; p=4e-4).  Curator chose the two top-ranked analogs.	none	7	
CYP4A11	Q02928	1579	Cyp4a10|13117;Cyp4a31|666168;Cyp4a32|100040843 (9e-4)	5	Difficult to classify Cyp450 proteins.  IMP identifies these three mouse proteins as the best analogs: Cyp4a10 (NCBI GeneID 13117; p=1e-05), Cyp4a31 (NCBI GeneID 666168; p=9e-4), and Cyp4a32 (NCBI GeneID 100040843; p=9e-4).  P-POD also identifies the following as orthologs: Cyp4a12a (NCBI GeneID 277753), Cyp4a12b (NCBI GeneID 13118), Cyp4a14 (NCBI GeneID 13119), and pseudogene Cyp4a30b-ps (NCBI GeneID 435802).	cyp4t8|387527	2	Difficult to classify Cyp450 proteins.  Zebrafish cyp4t8 is also orthologous to several other human CYP450 proteins.	none	7	
CYP4A22	Q5TCH4	284541	Cyp4a31|666168;Cyp4a32|100040843;Cyp4a10|13117	5	Difficult to classify Cyp450 proteins.  IMP identifies these three mouse proteins as the best analogs: Cyp4a31 (NCBI GeneID 666168; p=3e-4), Cyp4a32 (NCBI GeneID 100040843; p=3e-4), and Cyp4a10 (NCBI GeneID 13117; p=3e-3).  P-POD also identifies the following as orthologs: Cyp4a12a (NCBI GeneID 277753), Cyp4a12b (NCBI GeneID 13118), Cyp4a14 (NCBI GeneID 13119), and pseudogene Cyp4a30b-ps (NCBI GeneID 435802).	cyp4t8|387527	2	Difficult to classify Cyp450 proteins.  Zebrafish cyp4t8 is also orthologous to several other human CYP450 proteins.	none	7	
CYP4F11	Q9HBI6	57834	Cyp4f15|106648;Cyp4f40|631304	2	Difficult to classify Cyp450 proteins.  These mouse proteins are orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11.	cyp4f43|100037390	2	Difficult to classify Cyp450 proteins.  This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11.	none	7	
CYP4F2	P78329	8529	Cyp4f15|106648;Cyp4f40|631304	2	Difficult to classify Cyp450 proteins.  These mouse proteins are orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11.	cyp4f3|100037390	2	Difficult to classify Cyp450 proteins.  This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11.	none	7	
CYP4F22	Q6NT55	126410	CYP4F39|320997	1		cyp4f43|100037390	2	Difficult to classify Cyp450 proteins.  This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11.	none	7	
CYP4F3	Q08477	4051	Cyp4f15|106648;Cyp4f40|631304	2	Difficult to classify Cyp450 proteins.  These mouse proteins are orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11.	cyp4f3|100037390	2	Difficult to classify Cyp450 proteins.  This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11.	none	7	
CYP4F8	P98187	11283	Cyp4f15|106648;Cyp4f40|631304	2	Difficult to classify Cyp450 proteins.  These mouse proteins are orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11.	cyp4f3|100037390	2	Difficult to classify Cyp450 proteins.  This fish protein is orthologous to human CYP4F2, CYP4F3, CYP4F8, and CYP4F11.	none	7	
CYSLTR1	Q9Y271	10800	CYSLTR1|58861	1		cysltr1|553675	1		none	7	
CYSLTR2	Q9NS75	57105	CYSLTR2|70086	1		none	7		none	7	
DPEP1	P16444	1800	Dpep1|13479	2		zgc:153024|768195	2		none	7	
DPEP2	Q9H4A9	64174	Dpep2|319446	4	Human DPEP2 is paralogous to both mouse Dpep2 and Dpep3.	none	7		none	7	
EPHX2	P34913	2053	Ephx2|13850	2		ephx2|494099	2	P-POD shows a duplication and reciprocal loss among the vertebrates--chicken and zebrafish are in one clade and human, mouse, and rat are in the other--but that may be incorrect.  As a result, zebrafish ephx2, which P-POD shows as paralogous to hEPHX2, may actually be orthologous.	none	7	
GGT1	P19440	2678	Ggt1|14598	2		ggt1a|393387;ggt1b|569014	2		ECM38|YLR299W	2	
GGT5	P36269	2687	Ggt5|23887	2		none	7		none	7	
GGT6	Q6P531	124975	Ggt6|71522	1P		none	7		none	7	
GGT7	Q9UJ14	2686	GGT7|207182	1		none	7		none	7	
GPR44	Q9Y5Y4	11251	GPR44|14764	1		none	7	One ortholog has been removed from Ensembl.	none	7	
GPX1	P07203	2876	Gpx1|14775	2		gpx1a|352926	2		none	7	
GPX2	P18283	2877	Gpx2|14776	2		none	7		none	7	
GPX3	P22352	2878	GPX3|14778	1		gpx3|798788	2		none	7	
GPX4	P36969	2879	GPX4|625249	1		gpx4a|352928	2		none	7	Yeast genes are distantly related and paralogs.
GPX5	O75715	2880	Gpx5|14780	2		none	7		none	7	
GPX6	P59796	257202	Gpx6|75512	5	Human GPX6 is shown as paralogous to both mouse Gpx6 and Gpx5, but Gpx5 is orthologous to human GPX5.	none	7		none	7	
GPX7	Q96SL4	2882	GPX7|67305	1		gpx7|552981	2		none	7	
HPGD	P15428	3248	HPGD|15446	1		LOC565975|565975	2		none	7	
HPGDS	O60760	27306	Hpgds|54486	2		none	7		none	7	
LCAT	P04180	3931	LCAT|16816	1		lcat|793137	2		none	7	
LIPA	P38571	3988	LIPA|16889	1		lipf|406713	2	Lipf is orthologous to 2 clades of mammalian genes.	none	7	
LIPE	Q05469	3991	Lipe|16890	2		lipea|568368	2		none	7	
LIPG	Q9Y5X9	9388	LIPG|16891	1		lipg|393096	2		none	7	
LPCAT1	Q8NF37	79888	LPCAT1|210992	1		LPCAT1|555969	1		none	7	
LPCAT2	Q7L5N7	54947	LPCAT2|270084	1		lpcat2|553683	1	P-POD identifies lpcat2 as a paralog of hLPCAT2.	none	7	
LPCAT3	Q6P1A2	10162	LPCAT3|14792	1		none	7		none	7	
LTA4H	P09960	4048	LTA4H|16993	1		LTA4H|406575	1		none	7	Limited biochemical similarity to paralog LAP2/YNL045W.
LTB4R	Q15722	1241	LTB4R1|16995	1		si:ch211-272h9.2|100317356;LOC100329657|100329657	2		none	7	
LTB4R2	Q9NPC1	56413	LTB4R2|57260	1		none	7		none	7	
LTC4S	Q16873	4056	Ltc4s|17001	2		ltc4s|100535432	2		none	7	
MAPKAPK2	P49137	9261	MAPKAPK2|17164	1		MAPKAPK2A|327321	1		none	7	
MBOAT7	Q96N66	79143	MBOAT7|77582	1		MBOAT7|393509	1		none	7	
PAFAH2	Q99487	5051	PAFAH2|100163	1		none	7		none	7	
PLA2G10	O15496	8399	Pla2g10|26565	2		none	7		none	7	
PLA2G12A	Q9BZM1	81579	Pla2g12a|66350	2		pla2g12a|402802	2		none	7	
PLA2G12B	Q9BX93	84647	Pla2g12b|69836	1P		pla2g12b|406739	2P		none	7	
PLA2G1B	P04054	5319	Pla2g1b|18778	2		pla2g1b|571738	2		none	7	
PLA2G2A	P14555	5320	Pla2g2a|18780	2		none	7		none	7	
PLA2G2D	Q9UNK4	26279	PLA2G2D|18782	1		none	7		none	7	
PLA2G2E	Q9NZK7	30814	PLA2G2E|26970	1		none	7		none	7	
PLA2G2F	Q9BZM2	64600	PLA2G2F|26971	1		none	7		none	7	
PLA2G3	Q9NZ20	50487	Pla2g3|237625	2		zgc:123275|641423	2		none	7	
PLA2G4A	P47712	5321	PLA2G4A|18783	1		pla2g4a|559087;cpla2|30554	2		none	7	
PLA2G4B	P0C869	100137049	Pla2g4b|211429	1		LOC565386|565386	2	LOC565386 is uncharacterized and is orthologous to several paralogous mammalian clades.	none	7	
PLA2G4C	Q9UP65	8605	PLA2G4C|232889	1		zgc:101699|492789	2	P-POD lists 3 more fish orthologs with ENSEMBL IDs, but they don't map to Gene IDs.	none	7	
PLA2G4D	Q86XP0	283748	PLA2G4D|78390	1		LOC565386|565386	2	LOC565386 is uncharacterized and is orthologous to several paralogous mammalian clades.	none	7	
PLA2G4E	Q3MJ16	123745	PLA2G4E|329502	1		LOC565386|565386	2	LOC565386 is uncharacterized and is orthologous to several paralogous mammalian clades.	none	7	
PLA2G4F	Q68DD2	255189	PLA2G4F|271844	1		LOC565386|565386	2	LOC565386 is uncharacterized and is orthologous to several paralogous mammalian clades.	none	7	
PLA2G5	P39877	5322	Pla2g5|18784	2		none	7		none	7	
PLA2G6	O60733	8398	PLA2G6|53357	1		pla2g6|406370	2		none	7	
PLB1	Q6P1J6	151056	Plb1|665270	2		none	7		none	7	
PTGDR	Q13258	5729	PTGDR|19214	1		none	7		none	7	
PTGDS	P41222	5730	PTGDS|19215	1		ptgdsa|555483;ptgdsb|336492	6	P-POD identifies 3 orthologs: ptgsb plus 2 predicted or provisional genes.  IMP identifies ptgsa and -b, but ptgsa has a better p-value.	none	7	
PTGER1	P34995	5731	PTGER1|19216	1		none	7		none	7	
PTGER2	P43116	5732	PTGER2|19217	1		ptger2a|393608	6	P-POD also identifies ptger2b (NCBI GeneID 570410) as an ortholog of hPTGER2.	none	7	
PTGER3	P43115	5733	PTGER3|19218	1		PTGER3|100000544	2		none	7	
PTGER4	P35408	5734	PTGER4|19219	1		ptger4a|562469;ptger4b|100005416	8		none	7	
PTGES	O14684	9536	PTGES|64292	1		PTGES|544666	1		none	7	
PTGES2	Q9H7Z7	80142	PTGES2|96979	1		ptgesl|799964	2		none	7	
PTGES3	Q15185	10728	Ptges3|56351	1	P-POD identifies an additional mouse pseudogene.  UniProt identifier for Ptges3 maps to 3 NCBI Gene IDs, but 2 are deprecated or pseudogenes.	ptges3a|406449	1		none	7	Yeast ortholog SBA1 shares chaperone activity with PTGES3 but is not a prostaglandin synthase.
PTGFR	P43088	5737	PTGFR|19220	1		ptgfr|571808	2	A second locus, LOC100005681, is possibly a duplicate of ptgfr; it is also nearby.	none	7	
PTGIR	P43119	5739	PTGIR|19222	1		PTGIR|561406	2		none	7	
PTGIS	Q16647	5740	PTGIS|19223	1		ptgis|559148	2		none	7	
PTGR1	Q14914	22949	Ptgr1|67103	2		ptgr1|494108	1		none	7	The closest yeast gene is a paralog that is orthologous to another human gene.
PTGS1	P23219	5742	PTGS1|19224	1		ptgs1|246226	1		none	7	
PTGS2	P35354	5743	PTGS2|19225	1		ptgs2a|246227	8	Both P-POD and IMP identify both ptgs2a (NCBI GeneID 246227) and ptgs2b (NCBI GeneID 559020), but ptgs2a has a much better p-value in IMP.	none	7	
SLC27A2	O14975	11001	SLC27A2|26458	1		slc27a2|449925;slc27a2b|100004228	6	IMP identifes slc27a2, but the p-value is not very strong (3e-3).  P-POD identifies slc27a2b plus 2 other predicted/provisional proteins.	FAT1|YBR041W	3	
SOAT1	P35610	6646	SOAT1|20652	1		soat1|564424	2		none	7	
TBXA2R	P21731	6915	TBXA2R|21390	1		none	7	One ortholog in P-POD has been deprecated.	none	7	
TBXAS1	P24557	6916	TBXAS1|21391	1		TBXAS1|792041	1		none	7