Curator Name UniProt ID NCBI Gene ID Gene Name Species Name Taxonomy ID Data Type Data Value Value Unit ChEBI Chemical Term A ChEBI Chemical ID A ChEBI Chemical Term B ChEBI Chemical ID B Secondary Source IDs Secondary Source Notes Reviewed (Y/N) Use (Y/N) Evidence Code Primary Source Secondary Source PENTACON Notes Gene Set Secondary Source Version Date Secondary Source Version PENTACON Annotation No Faith P31749 207 AKT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 52.8 uM for ATP (for purified and in vitro activated AKT1) 52.8 uM ATP CHEBI:15422 Y Y ECO:0000006 PubMed:16540465 UniProtKB BP, DGA 4/3/2013 166 2200002601 Faith P31749 207 AKT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.5 uM for peptide substrate (for purified and in vitro activated AKT1) 0.5 uM peptide CHEBI:16670 Y Y UniProtKB BP, DGA 4/3/2013 166 2200002602 Faith P31749 207 AKT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 143.3 uM for ATP (for recombinant myristoylated AKT1 expressed and immunoprecipitated from Rat-1 cells) 143.3 uM ATP CHEBI:15422 Y Y UniProtKB BP, DGA 4/3/2013 166 2200002603 Faith P31749 207 AKT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.9 uM for peptide substrate (for recombinant myristoylated AKT1 expressed and immunoprecipitated from Rat-1 cells) 2.9 uM peptide CHEBI:16670 Y Y UniProtKB BP, DGA 4/3/2013 166 2200002604 Faith P00374 1719 DHFR Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.7 uM for dihydrofolate 2.7 uM dihydrofolic acid CHEBI:15633 Y Y ECO:0000006 PubMed:21876184 PubMed:15039552 PubMed:19196009 UniProtKB BP 4/3/2013 151 2200002605 Faith P00374 1719 DHFR Homo sapiens 9606 Comment/biophysicochemical properties/KM 4.0 uM for NADPH 4 uM NADPH CHEBI:16474 Y Y UniProtKB BP 4/3/2013 151 2200002606 Faith Q03393 5805 PTS Homo sapiens 9606 Comment/biophysicochemical properties/KM 8.1 uM for 7,8-dihydroneopterin triphosphate 8.1 uM 7,8-dihydroneopterin triphosphate CHEBI:NEW_161403 Y Y ECO:0000006 PubMed:10531334 UniProtKB No ChEBI term BP 4/3/2013 138 2200002607 Faith Q03393 5805 PTS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 120 nmol/min/mg enzyme with 7,8-dihydroneopterin triphosphate as substrate 120 nmol/min/mg 7,8-dihydroneopterin triphosphate CHEBI:NEW_161403 Y Y UniProtKB No ChEBI term BP 4/3/2013 138 2200002608 Faith Q03393 5805 PTS Homo sapiens 9606 Comment/biophysicochemical properties/KM 10 uM for 7,8-dihydroneopterin triphosphate 10 uM 7,8-dihydroneopterin triphosphate CHEBI:NEW_161403 Y Y PubMed:3536512 PENTACON No ChEBI term BP 4/21/2014 3 2200002609 Faith P35270 6697 SPR Homo sapiens 9606 Comment/biophysicochemical properties/KM 14.3 uM for sepiapterin 14.3 uM sepiapterin CHEBI:16095 Y Y ECO:0000006 PubMed:11825621 UniProtKB BP 4/3/2013 137 2200002610 Faith P35270 6697 SPR Homo sapiens 9606 Comment/biophysicochemical properties/KM 10 uM for NADPH 10 uM NADPH CHEBI:16474 Y Y UniProtKB BP 4/3/2013 137 2200002611 Katie P12821 1636 ACE Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.51 mM for Hip-His-Leu 2.51 mM Hip-His-Leu CHEBI:NEW_161404 Y Y ECO:0000006 PubMed:11076943 PubMed:12542396 UniProtKB No ChEBI term BP, DGA, AAE 4/3/2013 172 2200002612 Faith P08311 1511 CTSG Homo sapiens 9606 Comment/biophysicochemical properties/KM 1.15 mM for Z-Lys-SBzl 1.15 mM lysine derivative CHEBI:53079 Y Y ECO:0000006 PubMed:8194606 UniProtKB Z-Lys-SBzl not in ChEBI BP, DGA 4/3/2013 134 2200002613 Faith P08311 1511 CTSG Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.26 mM for Suc-Ala-Ala-Pro-Phe-SBzl 0.26 mM Suc-Ala-Ala-Pro-Phe-SBzl CHEBI:NEW_161405 Y Y UniProtKB no ChEBI term BP, DGA 4/3/2013 134 2200002614 Faith P08473 4311 MME Homo sapiens 9606 Comment/biophysicochemical properties/KM 55.1 uM for angiotensin-1 55.1 uM angiotensin CHEBI:48433 Y Y ECO:0000006 PubMed:15283675 UniProtKB angiotensin-I BP 4/3/2013 165 2200002615 Faith P08473 4311 MME Homo sapiens 9606 Comment/biophysicochemical properties/KM 179 uM for angiotensin-2 179 uM angiotensin II CHEBI:48432 Y Y UniProtKB BP 4/3/2013 165 2200002616 Faith P08473 4311 MME Homo sapiens 9606 Comment/biophysicochemical properties/KM 111.4 uM for angiotensin 1-9 111.4 uM angiotension 1-9 CHEBI:NEW_161406 Y Y UniProtKB no ChEBI term BP 4/3/2013 165 2200002617 Faith Q9BYF1 59272 ACE2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 6.9 uM for angiotensin I 6.9 uM angiotensin CHEBI:48433 Y Y ECO:0000006 PubMed:11815627 UniProtKB angiotensin-I BP, DGA 4/3/2013 114 2200002618 Faith Q9BYF1 59272 ACE2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2 uM for angiotensin II 2 uM angiotensin II CHEBI:48432 Y Y UniProtKB BP, DGA 4/3/2013 114 2200002619 Faith Q9BYF1 59272 ACE2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 6.8 uM for apelin-13 6.8 uM apelin-13 CHEBI:NEW_161407 Y Y UniProtKB no ChEBI term BP, DGA 4/3/2013 114 2200002620 Faith Q9BYF1 59272 ACE2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 5.5 uM for dynorphin-13 5.5 uM dynorphin-13 CHEBI:NEW_161408 Y Y UniProtKB no ChEBI term BP, DGA 4/3/2013 114 2200002621 Mike P30793 2643 GCH1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 116 uM for GTP 116 uM GTP CHEBI:15996 Y Y ECO:0000006 PubMed:2500984 UniProtKB synthetic petide serving as chromogenic substrate BP, DGA 4/3/2013 145 2200002627