Curator Name UniProt ID NCBI Gene ID Gene Name Species Name Taxonomy ID Data Type Data Value Value Unit ChEBI Chemical Term A ChEBI Chemical ID A ChEBI Chemical Term B ChEBI Chemical ID B Secondary Source IDs Secondary Source Notes Reviewed (Y/N) Use (Y/N) Evidence Code Primary Source Secondary Source PENTACON Notes Gene Set Secondary Source Version Date Secondary Source Version PENTACON Annotation No Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 549.0 pmol/min/mg hexadecan-1-ol CHEBI:16125 stearoyl-CoA CHEBI:15541 Y Y ECO:0000006 PubMed:15671038 PENTACON Two substrates, where first substrate is [14C] labeled. Info added from publication AAP 4/21/2014 3 2200001302 Faith O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.2 mM for glutathione for the prostaglandin D synthase activity 0.2 mM glutathione CHEBI:16856 prostaglandin H2 CHEBI:15554 Y Y PubMed:10824118 PENTACON PGDS activity listed as 30 umol/min/mg. However, does not explicitely state this is the Vmax. AAP, ASD 4/21/2014 3 2200001303 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 524.0 pmol/min/mg hexadecan-1-ol CHEBI:16125 palmitoyl-CoA CHEBI:15525 Y Y ECO:0000006 PubMed:15671038 PENTACON Two substrates, where first substrate is [14C] labeled. Info added from publication AAP 4/21/2014 3 2200001304 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1125.0 pmol/min/mg hexadecan-1-ol CHEBI:16125 palmitoleoyl-CoA CHEBI:53152 Y Y ECO:0000006 PubMed:15671038 PENTACON Two substrates, where first substrate is [14C] labeled. Info added from publication AAP 4/21/2014 3 2200001305 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 11.4 pmol/min/mg 1,2-dioleoyl-sn-glycerol CHEBI:52333 oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 PENTACON Two substrates, where second substrate is [14C] labeled. Info added from publication AAP 4/21/2014 3 2200001306 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 27.0 pmol/min/mg Arachidyl C-20 alcohol CHEBI:NONE_148495 oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 PENTACON I cannot find the first substrate. The class is 'fatty alcohol'. There is also a 'arachidyl group' in ChEBI. Two substrates, where second substrate is [14C] labeled. Info added from publication Request: arachidyl alcohol AAP 4/21/2014 3 2200001307 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1232 pmol/min/mg enzyme with [14C]cetyl-CoA as substrate 1232.0 pmol/min/mg hexadecan-1-ol CHEBI:16125 oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 UniProtKB Info in UniProt is incorrect. I will send an email to UniProt. Substrate 1 is [14C] labeled hexadecan-1-ol AAP 10/31/2012 72 2200001308 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1066.0 pmol/min/mg hexadecan-1-ol CHEBI:16125 oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 PENTACON Two substrates, where second substrate is [14C] labeled. Info added from publication AAP 4/21/2014 3 2200001309 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 665.0 pmol/min/mg hexadecan-1-ol CHEBI:16125 oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 PENTACON Two substrates, where second substrate is [14C] labeled. Info added from publication AAP 4/21/2014 3 2200001310 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 892.0 pmol/min/mg Oleyl C-18:1 alcohol CHEBI:NONE_148496 oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 PENTACON Two substrates, where second substrate is [14C] labeled. Info added from publication Request: oleyl alcohol AAP 4/21/2014 3 2200001311 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 582.0 pmol/min/mg Palmitoleyl C-16:1 alcohol CHEBI:NONE_148497 oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 PENTACON Two substrates, where second substrate is [14C] labeled. Info added from publication Request: palmitoleyl alcohol AAP 4/21/2014 3 2200001312 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 138.0 pmol/min/mg stearyl alcohol CHEBI:32154 oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 PENTACON Two substrates, where second substrate is [14C] labeled. Info added from publication AAP 4/21/2014 3 2200001313 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 6247 nmol/min/mg enzyme with arachidonoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates 6247.0 nmol/min/mg arachidonoyl-CoA CHEBI:15514 lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB Two substrates are required. The second substrate is given in Column N. LPC16:0 covers a connection of palmitoyl at either 1 or 2 in the glycero moiety. AAP 1/9/2013 82 2200001314 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 18148 nmol/min/mg enzyme with linoleoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates 18148.0 nmol/min/mg linoleoyl-CoA CHEBI:15530 lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB Two substrates are required. The second substrate is given in Column N. LPC16:0 covers a connection of palmitoyl at either 1 or 2 in the glycero moiety. AAP 1/9/2013 82 2200001315 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 4698 nmol/min/mg enzyme with oleoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates 4698.0 nmol/min/mg oleoyl-CoA CHEBI:15534 lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB Two substrates are required. The second substrate is given in Column N. LPC16:0 covers a connection of palmitoyl at either 1 or 2 in the glycero moiety. AAP 1/9/2013 82 2200001316 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1782 nmol/min/mg enzyme with palmitoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates 1782.0 nmol/min/mg palmitoyl-CoA CHEBI:15525 lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB Two substrates are required. The second substrate is given in Column N. LPC16:0 covers a connection of palmitoyl at either 1 or 2 in the glycero moiety. AAP 1/9/2013 82 2200001317 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 996 nmol/min/mg enzyme with stearoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates 996.0 nmol/min/mg stearoyl-CoA CHEBI:15541 lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB Two substrates are required. The second substrate is given in Column N. LPC16:0 covers a connection of palmitoyl at either 1 or 2 in the glycero moiety. AAP 1/9/2013 82 2200001318 Faith O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.2 mM for PGH2 for the prostaglandin D synthase activity 0.2 mM prostaglandin H2 CHEBI:15554 glutathione CHEBI:16856 Y Y PubMed:10824118 PENTACON PGDS activity listed as 30 umol/min/mg. However, does not explicitely state this is the Vmax. AAP, ASD 4/21/2014 3 2200001319 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/KM 1.1 mM for taurine toward choloyl-CoA 1.1 mM taurine CHEBI:15891 choloyl-CoA CHEBI:15519 Y Y ECO:0000006 PubMed:8034703 UniProtKB AAP, ASD 5/1/2013 102 2200001320 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/KM 5.8 mM for glycine toward choloyl-CoA 5.8 mM glycine CHEBI:15428 choloyl-CoA CHEBI:15519 Y Y UniProtKB AAP, ASD 5/1/2013 102 2200001321 Rose P24752 38 ACAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4 uM for acteoacetyl coenzyme A 4.0 uM acetoacetyl-CoA CHEBI:15345 Y Y ECO:0000006 PubMed:17371050 UniProtKB AAP, DGA, ASD 11/28/2012 141 2200001322 Rose P24752 38 ACAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 20 uM for coenzyme A 20.0 uM acetoacetyl-CoA CHEBI:15345 Y Y ECO:0000311 UniProtKB AAP, DGA, ASD 11/28/2012 141 2200001323 Rose P24752 38 ACAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 8 uM for 2-methylacteoacetyl coenzyme A 8.0 uM acetoacetyl-CoA CHEBI:15345 Y Y ECO:0000311 UniProtKB 2-methylacteoacetyl coenzyme A not in ChEBI, send request. AAP, DGA, ASD 11/28/2012 141 2200001324 Rose P24752 38 ACAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 508 uM for acetyl coenzyme A 508.0 uM acetoacetyl-CoA CHEBI:15345 Y Y ECO:0000311 UniProtKB AAP, DGA, ASD 11/28/2012 141 2200001325 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 35.8 uM for C10-acyl-CoA 35.8 uM decanoyl-CoA CHEBI:28493 Y Y ECO:0000006 PubMed:16940157 UniProtKB AAP 5/1/2013 87 2200001326 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 3.6 uM for C12-acyl-CoA 3.6 uM lauroyl-CoA CHEBI:15521 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2200001327 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.8 uM for C14-acyl-CoA 2.8 uM myristoyl-CoA CHEBI:15532 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2200001328 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 3.6 uM for C16-acyl-CoA 3.6 uM palmitoyl-CoA CHEBI:15525 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2200001329 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.4 uM for C18-acyl-CoA 2.4 uM stearoyl-CoA CHEBI:15541 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2200001330 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2 uM for C20-acyl-CoA 2.0 uM icosanoyl-CoA CHEBI:15527 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2200001331 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.4 uM for C16:1-acyl-CoA 2.4 uM hexadecenoyl-CoA CHEBI:24549 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2200001332 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4.1 uM for C18:1-acyl-CoA 4.1 uM unsaturated fatty acyl-CoA CHEBI:51006 Y Y PubMed:16940157 UniProtKB C18:1-acyl-CoA (should we assume that this is oleoyl-CoA?) AAP 5/1/2013 87 2200001333 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.1 uM for C18:1-trans-acyl-CoA 2.1 uM unsaturated fatty acyl-CoA CHEBI:51006 Y Y PubMed:16940157 UniProtKB C18:1-trans-acyl-CoA AAP 5/1/2013 87 2200001334 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 224 nmol/min/mg enzyme toward C10-acyl-CoA 224.0 nmol/min/mg decanoyl-CoA CHEBI:28493 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2200001335 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 700 nmol/min/mg enzyme toward C12-acyl-CoA 700.0 nmol/min/mg lauroyl-CoA CHEBI:15521 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2200001336 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 912 nmol/min/mg enzyme toward C14-acyl-CoA 912.0 nmol/min/mg myristoyl-CoA CHEBI:15532 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2200001337 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 691 nmol/min/mg enzyme toward C16-acyl-CoA 691.0 nmol/min/mg palmitoyl-CoA CHEBI:15525 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2200001338 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 597 nmol/min/mg enzyme toward C18-acyl-CoA 597.0 nmol/min/mg stearoyl-CoA CHEBI:15541 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2200001339 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 520 nmol/min/mg enzyme toward C20-acyl-CoA 520.0 nmol/min/mg icosanoyl-CoA CHEBI:15527 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2200001340 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 577 nmol/min/mg enzyme toward C16:1-acyl-CoA 577.0 nmol/min/mg hexadecenoyl-CoA CHEBI:24549 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2200001341 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 258 nmol/min/mg enzyme toward C18:1-acyl-CoA 258.0 nmol/min/mg unsaturated fatty acyl-CoA CHEBI:51006 Y Y PubMed:16940157 UniProtKB C18:1-acyl-CoA (should we assume that this is oleoyl-CoA?) AAP 5/1/2013 87 2200001342 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 309 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA 309.0 nmol/min/mg unsaturated fatty acyl-CoA CHEBI:51006 Y Y PubMed:16940157 UniProtKB C18:1-trans-acyl-CoA AAP 5/1/2013 87 2200001343 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4.9 uM for n-decanoyl-CoA 4.9 uM decanoyl-CoA CHEBI:28493 Y Y ECO:0000006 PubMed:19170545 UniProtKB n-decanoyl-CoA AAP, ASD 5/29/2013 101 2200001344 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 26 uM for n-octanoyl-CoA 26.0 uM octanoyl-CoA CHEBI:15533 Y Y PubMed:19170545 UniProtKB n-octanoyl-CoA AAP, ASD 5/29/2013 101 2200001345 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 5 uM for myristoyl-CoA 5.0 uM myristoyl-CoA CHEBI:15532 Y Y UniProtKB AAP, ASD 5/29/2013 101 2200001346 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 9 uM for palmitoyl-CoA 9.0 uM palmitoyl-CoA CHEBI:15525 Y Y UniProtKB AAP, ASD 5/29/2013 101 2200001347 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 9 uM for oleoyl-CoA 9.0 uM oleoyl-CoA CHEBI:15534 Y Y UniProtKB AAP, ASD 5/29/2013 101 2200001348 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 10 uM for 3,4-dihydrohyphenylacetyl-CoA 10.0 uM phenylacetyl-CoAs CHEBI:25981 Y Y PubMed:19170545 UniProtKB Typo in UniProt will be fixed in October release. Chemical name is 3,4-dihydroxyphenylacetyl-CoA (not in ChEBI). AAP, ASD 5/29/2013 101 2200001349 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 40 uM for 3-hydrohyphenylacetyl-CoA 40.0 uM phenylacetyl-CoAs CHEBI:25981 Y Y PubMed:19170545 UniProtKB Typo in UniProt will be fixed in October release. Chemical name is 3-hydroxyphenylacetyl-CoA (not in ChEBI). AAP, ASD 5/29/2013 101 2200001350 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 20 uM for arachidonoyl-CoA 20.0 uM arachidonoyl-CoA CHEBI:15514 Y Y PubMed:19170545 PENTACON Many substrates from this paper are not listed in UniProt. I added this one due to the scope of PENTACON. AAP, ASD 4/21/2014 3 2200001351 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 40.3 uM for C10-acyl-CoA 40.3 uM decanoyl-CoA CHEBI:28493 Y Y ECO:0000006 PubMed:16940157 UniProtKB AAP 5/29/2013 127 2200001352 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 8.9 uM for C12-acyl-CoA 8.9 uM lauroyl-CoA CHEBI:15521 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2200001353 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 1.6 uM for C14-acyl-CoA 1.6 uM myristoyl-CoA CHEBI:15532 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2200001354 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.0 uM for C16-acyl-CoA 2.0 uM palmitoyl-CoA CHEBI:15525 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2200001355 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.8 uM for C18-acyl-CoA 2.8 uM stearoyl-CoA CHEBI:15541 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2200001356 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4.8 uM for C20-acyl-CoA 4.8 uM icosanoyl-CoA CHEBI:15527 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2200001357 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4.5 uM for C16:1-acyl-CoA 4.5 uM hexadecenoyl-CoA CHEBI:24549 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2200001358 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 6.1 uM for C18:1-acyl-CoA 6.1 uM unsaturated fatty acyl-CoA CHEBI:51006 Y Y UniProtKB C18:1-acyl-CoA (should we assume that this is oleoyl-CoA?) AAP 5/29/2013 127 2200001359 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4.3 uM for C18:1-trans-acyl-CoA 4.3 uM unsaturated fatty acyl-CoA CHEBI:51006 Y Y UniProtKB C18:1-trans-acyl-CoA AAP 5/29/2013 127 2200001360 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 212 nmol/min/mg enzyme toward C10-acyl-CoA 212.0 nmol/min/mg decanoyl-CoA CHEBI:28493 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2200001361 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 681 nmol/min/mg enzyme toward C12-acyl-CoA 681.0 nmol/min/mg lauroyl-CoA CHEBI:15521 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2200001362 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 766 nmol/min/mg enzyme toward C14-acyl-CoA 766.0 nmol/min/mg myristoyl-CoA CHEBI:15532 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2200001363 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 656 nmol/min/mg enzyme toward C16-acyl-CoA 656.0 nmol/min/mg palmitoyl-CoA CHEBI:15525 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2200001364 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 488 nmol/min/mg enzyme toward C18-acyl-CoA 488.0 nmol/min/mg stearoyl-CoA CHEBI:15541 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2200001365 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 408 nmol/min/mg enzyme toward C20-acyl-CoA 408.0 nmol/min/mg icosanoyl-CoA CHEBI:15527 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2200001366 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 661 nmol/min/mg enzyme toward C16:1-acyl-CoA 661.0 nmol/min/mg hexadecenoyl-CoA CHEBI:24549 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2200001367 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 304 nmol/min/mg enzyme toward C18:1-acyl-CoA 304.0 nmol/min/mg unsaturated fatty acyl-CoA CHEBI:51006 Y Y UniProtKB C18:1-acyl-CoA (should we assume that this is oleoyl-CoA?) AAP 5/29/2013 127 2200001368 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 418 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA 418.0 nmol/min/mg unsaturated fatty acyl-CoA CHEBI:51006 Y Y UniProtKB C18:1-trans-acyl-CoA AAP 5/29/2013 127 2200001369 Faith Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/KM 14 uM for succinyl-CoA 14.0 uM succinyl-CoA CHEBI:15380 Y Y ECO:0000006 PubMed:16940157 UniProtKB AAP 5/1/2013 92 2200001370 Faith Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/KM 147 uM for glutaryl-CoA 147.0 uM glutaryl-CoA CHEBI:15524 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 92 2200001371 Faith Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/KM 3.4 uM for C14-acyl-CoA 3.4 uM myristoyl-CoA CHEBI:15532 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 92 2200001372 Faith Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 581 nmol/min/mg enzyme toward succinyl-CoA 581.0 nmol/min/mg succinyl-CoA CHEBI:15380 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 92 2200001373 Faith Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 132 nmol/min/mg enzyme toward glutaryl-CoA 132.0 nmol/min/mg glutaryl-CoA CHEBI:15524 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 92 2200001374 Faith Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 137 nmol/min/mg enzyme toward C14-acyl-CoA 137.0 nmol/min/mg myristoyl-CoA CHEBI:15532 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 92 2200001375 Katie Q9ULC5 51703 ACSL5 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.11 uM for palmitic acid (isoform 1 at pH 7.5) 0.11 uM palmitic acid CHEBI:15756 Y Y ECO:0000006 PubMed:17681178 UniProtKB Curated by Faith. pH 7.5 AAP, AAP-M 11/28/2012 121 2200001376 Katie Q9ULC5 51703 ACSL5 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.38 uM for palmitic acid (isoform 1 at pH 9.5) 0.38 uM palmitic acid CHEBI:15756 Y Y ECO:0000311 UniProtKB Curated by Faith AAP, AAP-M 11/28/2012 121 2200001377 Katie Q9ULC5 51703 ACSL5 Homo sapiens 9606 0.04 uM for palmitic acid (isoform 3 at pH 7.5) 0.04 uM palmitic acid CHEBI:15756 Y Y ECO:0000311 UniProtKB Curated by Faith AAP, AAP-M 11/28/2012 121 2200001378 Katie Q9ULC5 51703 ACSL5 Homo sapiens 9606 0.15 uM for palmitic acid (isoform 3 at pH 8.5) 0.15 uM palmitic acid CHEBI:15756 Y Y ECO:0000311 UniProtKB Curated by Faith AAP, AAP-M 11/28/2012 121 2200001379 Rose P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 1.0 uM for androstanediol 1.0 uM androstane-3,17-diol CHEBI:27727 Y Y ECO:0000311 UniProtKB AAP, ASD 2/6/2013 142 2200001380 Rose P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 4.4 nmol/min/mg enzyme with androstanediol as substrate 4.4 nmol/min/mg androstane-3,17-diol CHEBI:27727 Y Y ECO:0000311 UniProtKB AAP, ASD 2/6/2013 142 2200001381 Rose P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 142.1 uM for progesterone 142.1 uM progesterone CHEBI:17026 Y Y ECO:0000006 PubMed:10557352 UniProtKB AAP, ASD 2/6/2013 142 2200001382 Rose P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 20.1 nmol/min/mg enzyme with progesterone as substrate 20.1 nmol/min/mg progesterone CHEBI:17026 Y Y ECO:0000311 UniProtKB AAP, ASD 2/6/2013 142 2200001383 Rose P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.37 uM for 5-alpha-dihydrotestosterone 2.37 uM testosterone CHEBI:17347 Y Y ECO:0000311 UniProtKB 5-alpha-dihydrotestosterone not in ChEBI, send request. AAP, ASD 2/6/2013 142 2200001384 Rose P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1.8 nmol/min/mg enzyme with 5-alpha-dihydrotestosterone as substrate 1.8 nmol/min/mg testosterone CHEBI:17347 Y Y ECO:0000311 UniProtKB AAP, ASD 2/6/2013 142 2200001385 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.2 mM for 2-fluoro-beta-alanine toward choloyl-CoA 2.2 mM beta-alanine derivative CHEBI:22823 Y Y UniProtKB 2-fluoro-beta-alanine AAP, ASD 5/1/2013 102 2200001386 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/KM 19.3 uM for arachidoyl-CoA 19.3 uM icosanoyl-CoA CHEBI:15527 Y Y UniProtKB AAP, ASD 5/1/2013 102 2200001387 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.33 umol/min/mg enzyme with taurine as substrate for acyltransferase activity 0.33 umol/min/mg taurine CHEBI:15891 Y Y UniProtKB AAP, ASD 5/1/2013 102 2200001388 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.19 umol/min/mg enzyme with 2-fluoro-beta-alanine as substrate for acyltransferase activity 0.19 umol/min/mg beta-alanine derivative CHEBI:22823 Y Y UniProtKB 2-fluoro-beta-alanine AAP, ASD 5/1/2013 102 2200001389 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.77 umol/min/mg enzyme with glycine as substrate for acyltransferase activity 0.77 umol/min/mg glycine CHEBI:15428 Y Y UniProtKB AAP, ASD 5/1/2013 102 2200001390 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 223 nmol/min/mg enzyme with arachidoyl-CoA as substrate for acyl-CoA thioesterase activity 223.0 nmol/min/mg icosanoyl-CoA CHEBI:15527 Y Y UniProtKB AAP, ASD 5/1/2013 102 2200001391 Mike P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 173 uM for daunorubicin 173.0 uM daunorubicin CHEBI:41977 Y Y ECO:0000311 UniProtKB AAP, ASD 11/28/2012 147 2200001392 Mike P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 22 uM for menadione 22.0 uM menadione CHEBI:28869 Y Y ECO:0000311 UniProtKB AAP, ASD 11/28/2012 147 2200001393 Mike P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 247 uM for NADPH 247.0 uM NADPH CHEBI:16474 Y Y ECO:0000311 UniProtKB AAP, ASD 11/28/2012 147 2200001394 Mike P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 309 uM for prostaglandin E2 309.0 uM prostaglandin E2 CHEBI:15551 Y Y ECO:0000311 UniProtKB AAP, ASD 11/28/2012 147 2200001395 Mike P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 30 uM for S-nitrosoglutathione 30.0 uM S-nitrosoglutathione CHEBI:50091 Y Y ECO:0000006 PubMed:18826943 PubMed:17344335 UniProtKB AAP, ASD 11/28/2012 147 2200001396 Mike O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 25 uM for menadione (PubMed:15537833) 25.0 uM menadione CHEBI:28869 Y Y ECO:0000006 PubMed:15537833 UniProtKB AAP, ASD 11/28/2012 115 2200001397 Mike O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 43 uM for menadione (PubMed:18493841) 43.0 uM menadione CHEBI:28869 Y Y ECO:0000006 PubMed:18493841 UniProtKB AAP, ASD 11/28/2012 115 2200001398 Mike O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 90 uM for NADPH (PubMed:15537833) 90.0 uM NADPH CHEBI:16474 Y Y ECO:0000006 PubMed:15537833 UniProtKB AAP, ASD 11/28/2012 115 2200001399 Mike O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 38 uM for NADPH (PubMed:18493841) 38.0 uM NADPH CHEBI:16474 Y Y ECO:0000006 PubMed:18493841 UniProtKB AAP, ASD 11/28/2012 115 2200001400 Mike P05177 1544 CYP1A2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 71 uM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine 71.0 uM 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine CHEBI:NONE_148498 Y Y ECO:0000311 UniProtKB request from ChEBI:2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine AAP, DGA, ASD 11/28/2012 140 2200001401 Mike P05177 1544 CYP1A2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 26 uM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline 26.0 uM 2-amino-2,4-dimethylimidazo[4,5-f]quinoline CHEBI:NONE_148499 Y Y ECO:0000311 UniProtKB request from ChEBI:2-amino-2,4-dimethylimidazo[4,5-f]quinoline AAP, DGA, ASD 11/28/2012 140 2200001402 Mike P05177 1544 CYP1A2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 21 uM for 2-amino-3-methylimidazo[4,5-f]quinoline 21.0 uM 2-amino-3-methylimidazo[4,5-f]quinoline CHEBI:NONE_148500 Y Y ECO:0000311 UniProtKB request from ChEBI: 2-amino-3-methylimidazo[4,5-f]quinoline AAP, DGA, ASD 11/28/2012 140 2200001403 Mike P05177 1544 CYP1A2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 27 uM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline 27.0 uM 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline CHEBI:NONE_148501 Y Y ECO:0000311 UniProtKB request from ChEBI:2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline AAP, DGA, ASD 11/28/2012 140 2200001404 Mike/Rose P05177 1544 CYP1A2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4 uM for 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole 4.0 uM 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole CHEBI:NONE_148502 Y Y ECO:0000006 PubMed:14725854 UniProtKB request from ChEBI: 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole; PUBCHEMcid:49971 AAP, DGA, ASD 11/28/2012 140 2200001405 Mike P05177 1544 CYP1A2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 25 uM for phenacetin 25.0 uM phenacetin CHEBI:8050 Y Y ECO:0000311 UniProtKB AAP, DGA, ASD 11/28/2012 140 2200001406 Katie Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 6.0 uM for 17-beta-estradiol 6.0 uM 17beta-estradiol CHEBI:16469 Y Y ECO:0000006 PubMed:10426814 UniProtKB Curated by Faith AAP, ASD 11/28/2012 148 2200001407 Katie Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 14.95 nmol/min/mg enzyme for 17-beta-estradiol 4-hydroxylation 14.95 nmol/min/mg 17beta-estradiol CHEBI:16469 Y Y ECO:0000311 UniProtKB Curated by Faith 4-hydroxylation AAP, ASD 11/28/2012 148 2200001408 Katie Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 6.9 nmol/min/mg enzyme for 17-beta-estradiol 2-hydroxylation 6.9 nmol/min/mg 17beta-estradiol CHEBI:16469 Y Y ECO:0000311 UniProtKB Curated by Faith 2-hydroxylation AAP, ASD 11/28/2012 148 2200001409 Katie Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 24.0 uM for progesterone 24.0 uM progesterone CHEBI:17026 Y Y ECO:0000311 UniProtKB Curated by Faith AAP, ASD 11/28/2012 148 2200001410 Katie Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 9.86 nmol/min/mg enzyme for progesterone 6-beta-hydroxylation 9.86 nmol/min/mg progesterone CHEBI:17026 Y Y ECO:0000311 UniProtKB Curated by Faith AAP, ASD 11/28/2012 148 2200001411 Katie Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 37.80 nmol/min/mg enzyme for progesterone 16-alpha-hydroxylation 37.8 nmol/min/mg progesterone CHEBI:17026 Y Y ECO:0000311 UniProtKB Curated by Faith AAP, ASD 11/28/2012 148 2200001412 Katie/Faith Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 17.0 uM for testosterone 17.0 uM testosterone CHEBI:17347 Y Y ECO:0000311 UniProtKB Curated by Faith AAP, ASD 11/28/2012 148 2200001413 Katie/Faith Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 36.16 nmol/min/mg enzyme for testosterone 6-beta-hydroxylation 36.16 nmol/min/mg testosterone CHEBI:17347 Y Y ECO:0000311 UniProtKB Curated by Faith AAP, ASD 11/28/2012 148 2200001414 Rose P20813 1555 CYP2B6 Homo sapiens 9606 Comment/biophysicochemical properties/KM 360 uM for 1,4-cineole 360.0 uM cineole CHEBI:23243 Y Y ECO:0000006 PubMed:11695850 UniProtKB 1,4-cineole not in ChEBI, send request. AAP, ASD 11/28/2012 143 2200001415 Rose P20813 1555 CYP2B6 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 3.4 nmol/min/nmol enzyme toward 2-exo-hydroxy-1,4-cineole 3.4 nmol/min/nmol cineole CHEBI:23243 Y Y ECO:0000311 UniProtKB 2-exo-hydroxy-1,4-cineole not in ChEBI,send request. AAP, ASD 11/28/2012 143 2200001416 Faith Q7Z449 113612 CYP2U1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.7 uM for arachidonic acid 2.7 uM arachidonic acid CHEBI:15843 Y Y ECO:0000311 UniProtKB AAP 11/28/2012 94 2200001417 Faith Q5TCH4 284541 CYP4A22 Homo sapiens 9606 Comment/biophysicochemical properties/KM 56.7 uM for laurate 56.7 uM laurate CHEBI:18262 Y Y ECO:0000006 PubMed:10860550 UniProtKB AAP 11/28/2012 75 2200001418 Faith Q5TCH4 284541 CYP4A22 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax Vmax:15.2 umol/min/umol enzyme. 15.2 umol/min/umol laurate CHEBI:18262 Y Y ECO:0000006 PubMed:10860550 UniProtKB AAP 11/28/2012 75 2200001419 Faith P98187 11283 CYP4F8 Homo sapiens 9606 Comment/biophysicochemical properties/KM 7 uM for 9-alpha,11-alpha-epoxymethano-PGH2 (U-44069) 7.0 uM prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 PubMed:10791960 UniProtKB Substrate used is a stable analog of PGH2. Request: 9-alpha,11-alpha-epoxymethano-PGH2 (U-44069) AAP 2/6/2013 106 2200001420 Faith P98187 11283 CYP4F8 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax The Vmax of the reaction with U-44069 as substrate is 260 pmol/min/pmol enzyme. 260.0 pmol/min/pmol prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 PubMed:10791960 UniProtKB Substrate used is a stable analog of PGH2. Request: 9-alpha,11-alpha-epoxymethano-PGH2 (U-44069) AAP 2/6/2013 106 2200001421 Faith P98187 11283 CYP4F8 Homo sapiens 9606 Comment/biophysicochemical properties/KM 40 uM for 6,9-alpha-methylene-PGI2 40.0 uM prostaglandin I2 CHEBI:15552 Y Y ECO:0000006 PubMed:15789615 UniProtKB Substrate used is a stable analog of PGI2. Request: 6,9-alpha-methylene-PGI2 AAP 2/6/2013 106 2200001422 Rose P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 1.1 mM for p-nitrophenyl phosphate 1.1 mM 4-nitrophenyl phosphate CHEBI:17440 Y Y ECO:0000311 UniProtKB AAP, DGA, ASD 1/9/2013 131 2200001423 Rose P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 5.8 nmol/min/mg enzyme with p-nitrophenyl phosphate 5.8 nmol/min/mg 4-nitrophenyl phosphate CHEBI:17440 Y Y ECO:0000311 UniProtKB AAP, DGA, ASD 1/9/2013 131 2200001424 Rose P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 338 nmol/min/mg enzyme with threo-9,10-phosphonooxy-hydroxy-octadecanoic acid 338.0 nmol/min/mg Y Y ECO:0000311 UniProtKB AAP, DGA, ASD 1/9/2013 131 2200001425 Katie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM 38 uM for NAD 38.0 uM NAD(+) CHEBI:15846 Y Y ECO:0000006 PubMed:16828555 UniProtKB Curated by Faith. I put NAD+ instead of NAD because that is how substrate is listed in the ref AAP, ASD 2/6/2013 135 2200001426 Katie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM 3.4 uM for prostaglandin E2 3.4 uM prostaglandin E2 CHEBI:15551 Y Y ECO:0000006 PubMed:16828555 UniProtKB Curated by Faith AAP, ASD 2/6/2013 135 2200001427 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 5.1 umol/min/mg enzyme with 1-chloro-2,4-dinitrobenzene as substrate 5.1 umol/min/mg 1-chloro-2,4-dinitrobenzene CHEBI:34718 Y Y ECO:0000311 UniProtKB AAP, ASD 2/6/2013 124 2200001428 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 44.3 umol/min/mg enzyme with 1-fluoro-2,4-dinitrobenzene as substrate 44.3 umol/min/mg 1-fluoro-2,4-dinitrobenzene CHEBI:53049 Y Y ECO:0000311 UniProtKB AAP, ASD 2/6/2013 124 2200001429 Mike/Rose O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 6.8 umol/min/mg enzyme with allyl isothiocyanate as substrate 6.8 umol/min/mg allyl isothiocyanate CHEBI:73224 Y Y ECO:0000311 UniProtKB request from ChEBI: allyl isothiocyanate; PUBCHEMcid:5971 AAP, ASD 2/6/2013 124 2200001430 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 6.3 umol/min/mg enzyme with benzyl isothiocyanate as substrate 6.3 umol/min/mg benzyl isothiocyanate CHEBI:17484 Y Y ECO:0000311 UniProtKB AAP, ASD 2/6/2013 124 2200001431 Mike/Rose O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.05 umol/min/mg enzyme with cumene hydroperoxide as substrate 0.05 umol/min/mg cumene hydroperoxide CHEBI:NONE_148503 Y Y ECO:0000311 UniProtKB request from ChEBI: cumene hydroperoxide; PUBCHEMcid:6629 AAP, ASD 2/6/2013 124 2200001432 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 8.6 umol/min/mg enzyme with 1-bromo-2,4-dinitrobenzene as substrate 8.6 umol/min/mg dinitrobenzene CHEBI:51396 Y Y ECO:0000311 UniProtKB request from ChEBI AAP, ASD 2/6/2013 124 2200001433 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 10.7 umol/min/mg enzyme with 1-iodo-2,4-dinitrobenzene as substrate 10.7 umol/min/mg dinitrobenzene CHEBI:51396 Y Y ECO:0000311 UniProtKB request from ChEBI AAP, ASD 2/6/2013 124 2200001434 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/KM 8 mM for glutathione for the glutathione-conjugating activity 8.0 mM glutathione CHEBI:16856 Y Y ECO:0000006 PubMed:11672424 PubMed:12627223 PubMed:15113825 UniProtKB AAP, ASD 2/6/2013 124 2200001435 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.6 mM for glutathione for the prostaglandin D synthase activity in the presence of EDTA 0.6 mM glutathione CHEBI:16856 Y Y ECO:0000311 UniProtKB AAP, ASD 2/6/2013 124 2200001436 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.14 mM for glutathione for the prostaglandin D synthase activity in the presence of magnesium ions 0.14 mM glutathione CHEBI:16856 Y Y ECO:0000311 UniProtKB AAP, ASD 2/6/2013 124 2200001437 Mike P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.4 mM for HDL(2) 0.4 mM high-density lipoprotein CHEBI:39025 Y Y ECO:0000311 UniProtKB request from ChEBI AAP, DGA 11/28/2012 141 2200001438 Mike P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.10 mM for HDL(3) 0.1 mM high-density lipoprotein CHEBI:39025 Y Y ECO:0000311 UniProtKB request from ChEBI AAP, DGA 11/28/2012 141 2200001439 Mike P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 8.3 mmol/min/mg enzyme with LDL as substrate 8.3 mmol/min/mg high-density lipoprotein CHEBI:39025 Y Y ECO:0000311 UniProtKB AAP, DGA 11/28/2012 141 2200001440 Mike P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.58 mmol/min/mg enzyme with HDL(2) as substrate 0.58 mmol/min/mg high-density lipoprotein CHEBI:39025 Y Y ECO:0000311 UniProtKB request from ChEBI AAP, DGA 11/28/2012 141 2200001441 Mike P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2.0 mmol/min/mg enzyme with HDL(3) as substrate 2.0 mmol/min/mg high-density lipoprotein CHEBI:39025 Y Y ECO:0000311 UniProtKB request from ChEBI AAP, DGA 11/28/2012 141 2200001442 Mike P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.97 mM for LDL 0.97 mM low-density lipoprotein CHEBI:39026 Y Y ECO:0000006 PubMed:10329423 UniProtKB AAP, DGA 11/28/2012 141 2200001443 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 71.56 uM for arachidonoyl-CoA 71.56 uM arachidonoyl-CoA CHEBI:15514 Y Y ECO:0000311 UniProtKB AAP 1/9/2013 82 2200001444 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 201.4 uM for linoleoyl-CoA 201.4 uM linoleoyl-CoA CHEBI:15530 Y Y ECO:0000311 UniProtKB AAP 1/9/2013 82 2200001445 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 72.19 uM for 1-palmitoyl-lysophosphatidylcholine 72.19 uM lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB LPC16:0 covers a connection of palmitoyl at either 1 or 2 in the glycero moiety. AAP 1/9/2013 82 2200001446 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 72.68 uM for oleoyl-CoA 72.68 uM oleoyl-CoA CHEBI:15534 Y Y ECO:0000311 UniProtKB AAP 1/9/2013 82 2200001447 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 41.29 uM for palmitoyl-CoA 41.29 uM palmitoyl-CoA CHEBI:15525 Y Y ECO:0000006 PubMed:18195019 UniProtKB AAP 1/9/2013 82 2200001448 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 36.65 uM for stearoyl-CoA 36.65 uM stearoyl-CoA CHEBI:15541 Y Y ECO:0000311 UniProtKB AAP 1/9/2013 82 2200001449 Rose P47712 5321 PLA2G4A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2.7 umol/min/mg enzyme for the phospholipase A2 reaction 2.7 umol/min/mg Y Y ECO:0000006 PubMed:8083230 UniProtKB AAP, ASD 11/28/2012 140 2200001450 Rose P47712 5321 PLA2G4A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 4.6 umol/min/mg enzyme for the lysophosphatase reaction 4.6 umol/min/mg Y Y ECO:0000311 UniProtKB AAP, ASD 11/28/2012 140 2200001451 Mike P0C869 100137049 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2.1 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PC as substrate (isoform 5) 2.1 nmol/min/ug 1-O-palmitoyl-2-O-arachidonoyl-sn-glycero-3-phosphocholine CHEBI:60378 Y Y ECO:0000311 UniProtKB isoform 5 AAP 11/28/2012 45 2200001452 Mike P0C869 100137049 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 3.6 pmol/min/ug enzyme with cAMP as substrate (isoform 4) 3.6 pmol/min/ug 3',5'-cyclic AMP CHEBI:17489 Y Y ECO:0000311 UniProtKB AAP 11/28/2012 45 2200001453 Mike P0C869 100137049 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.6 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 5) 0.6 nmol/min/ug dialkylglycerophosphoethanolamine CHEBI:37814 Y Y ECO:0000311 UniProtKB request from ChEBI: 1-16:0-2-[14C]20:4-PE AAP 11/28/2012 45 2200001454 Mike P0C869 100137049 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.8 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 3) 0.8 nmol/min/ug dialkylglycerophosphoethanolamine CHEBI:37814 Y Y ECO:0000311 UniProtKB request from ChEBI: 1-16:0-2-[14C]20:4-PE AAP 11/28/2012 45 2200001455 Mike P0C869 100137049 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.3 nmol/min/ug enzyme with 1-16:0-2-[14C]18:2-PE as substrate (isoform 3) 0.3 nmol/min/ug dialkylglycerophosphoethanolamine CHEBI:37814 Y Y ECO:0000311 UniProtKB request from ChEBI: 1-16:0-2-[14C]18:2-PE AAP 11/28/2012 45 2200001456 Mike P0C869 100137049 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 140 nmol/min/ug enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 5) 140.0 nmol/min/ug lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB request from ChEBI: 1-[14C]16:0-2-lyso-PC AAP 11/28/2012 45 2200001457 Mike P0C869 100137049 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1.6 nmol/min/ug enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 3) 1.6 nmol/min/ug lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB request from ChEBI: 1-[14C]16:0-2-lyso-PC AAP 11/28/2012 45 2200001458 Mike P0C869 100137049 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 7.9 pmol/min/mg enzyme (isoform 5) 7.9 pmol/min/mg Y Y ECO:0000006 PubMed:10085124 UniProtKB substrate unclear AAP 11/28/2012 45 2200001459 Faith Q9UP65 8605 PLA2G4C Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 218 pmol/min/mg enzyme 218.0 pmol/min/mg 1-O-palmitoyl-2-O-arachidonoyl-sn-glycero-3-phosphocholine CHEBI:60378 Y Y ECO:0000006 PubMed:10085124 UniProtKB Curated by Faith. Article states that enzyme assay carried out as previously in two cited articles. One article used 1-palmitoyl-2-[14C]arachidonoyl-sn-glycero-3-phosphocholine and other [14C]arachidonoyl phosphatidylcholine. I could note phosphatidylcholine, but there are more specific options (diacylPC or specificacylPC AAP 11/28/2012 93 2200001460 Faith Q15185 10728 PTGES3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 14 uM for PGH2 14.0 uM prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 PubMed:10922363 UniProtKB AAP, ASD 2/6/2013 125 2200001461 Faith Q15185 10728 PTGES3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 190 nmol/min/mg enzyme toward PGH2 190.0 nmol/min/mg prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 PubMed:10922363 UniProtKB AAP, ASD 2/6/2013 125 2200001462 Rose P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 16.2 uM for arachidonate (in absence of sodium nitroprusside NO donor) 16.2 uM arachidonate CHEBI:32395 Y Y ECO:0000006 PubMed:16373578 UniProtKB AAP, DGA, AAP-M, ASD 2/6/2013 143 2200001463 Rose P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 17.0 uM for arachidonate (in presence of sodium nitroprusside NO donor) 17.0 uM arachidonate CHEBI:32395 Y Y ECO:0000311 UniProtKB AAP, DGA, AAP-M, ASD 2/6/2013 143 2200001464 Rose P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 81.3 nmol/min/mg enzyme (in absence of sodium nitroprusside NO donor) 81.3 nmol/min/mg Y Y ECO:0000311 UniProtKB AAP, DGA, AAP-M, ASD 2/6/2013 143 2200001465 Rose P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 132 nmol/min/mg enzyme (in absence of sodium nitroprusside NO donor) 132.0 nmol/min/mg Y Y ECO:0000311 UniProtKB AAP, DGA, AAP-M, ASD 2/6/2013 143 2200001466 Faith P53816 11145 PLA2G16 Homo sapiens 9606 Comment/biophysicochemical properties/KM 300 uM for dipalmitoyl-PC 300.0 uM 1,2-di-O-palmitoyl-sn-glycero-3-phosphocholine CHEBI:40265 Y Y ECO:0000006 PubMed:19615464 UniProtKB AAP 5/29/2013 109 2200001467 Faith P53816 11145 PLA2G16 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2.57 umol/min/mg enzyme with dipalmitoyl-PC as substrate 2.57 umol/min/mg 1,2-di-O-palmitoyl-sn-glycero-3-phosphocholine CHEBI:40265 Y Y PubMed:19615464 UniProtKB AAP 5/29/2013 109 2200001468 Faith P53816 11145 PLA2G16 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 267 nmol/min/mg enzyme with dipalmitoyl-PE as substrate 267.0 nmol/min/mg 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine CHEBI:73127 Y Y UniProtKB AAP 5/29/2013 109 2200001469 Faith P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4.5 uM for arachidonate 4.5 uM arachidonate CHEBI:32395 Y Y PubMed:7947975 PENTACON also contains IC50 values for various NSAIDs AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001470 Faith P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 5.1 uM for arachidonate 5.1 uM arachidonate CHEBI:32395 Y Y PubMed:7947975 PENTACON also contains IC50 values for various NSAIDs AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001471 Faith P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 10.2 uM for [3H]arachidonic acid 10.2 uM arachidonic acid CHEBI:15843 Y Y PubMed:9139685 PENTACON [3H]arachidonic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001472 Faith P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 10.0 uM for [3H]arachidonic acid 10.0 uM arachidonic acid CHEBI:15843 Y Y PubMed:9139685 PENTACON [3H]arachidonic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001473 Faith P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.9 uM for arachidonic acid 0.9 uM arachidonic acid CHEBI:15843 Y Y PubMed:7979387 PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001474 Faith P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 1.1 uM for arachidonic acid 1.1 uM arachidonic acid CHEBI:15843 Y Y PubMed:12433707 PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001475 Faith P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 1.7 uM for arachidonate 1.7 uM arachidonate CHEBI:32395 Y Y PubMed:16770009 PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001476 Faith P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 9.2 uM for arachidonic acid 9.2 uM arachidonic acid CHEBI:15843 Y Y PubMed:19218248 PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001477 Faith P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 9 uM for arachidonic acid 9.0 uM arachidonic acid CHEBI:15843 Y Y PubMed:11602656 PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001478 Faith P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 14.7 uM for arachidonic acid 14.7 uM arachidonic acid CHEBI:15843 Y Y PubMed:9172778 PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001479 Faith Q16647 5740 PTGIS Homo sapiens 9606 Comment/biophysicochemical properties/Km 30 uM for PGH2 30.0 uM prostaglandin H2 CHEBI:15554 Modeling Data; Michaelis Y Y ECO:0000006 PubMed:15115769 PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001480 Faith Q16647 5740 PTGIS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 15 umol/min/mg enzyme with PGH2 as substrate 15.0 umol/min/mg prostaglandin H2 CHEBI:15554 Modeling Data; Michaelis Y Y PubMed:15115769 PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001481 Jodi O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.2 {glutathione} <31> 0.2 mM glutathione CHEBI:16856 5.3.99.2 Y Y ECO:0000033 Pubmed:11672424 BRENDA <31> Jowsey, I.R.; Thomson, A.M.; Flanagan, J.U.; Murdock, P.R.; Moore,G.B.T.; Meyer, D.J.; Murphy, G.J.; Smith, S.A.; Hayes, J.D.: Mammalianclass Sigma glutathione S-transferases: catalytic properties andtissue-specific expression of human and rat GSH-dependent prostaglandinD2 synthases. Biochem. J. (2001) 359, 507-516. {Pubmed:11672424} AAP, ASD 12/7/2011 1111 2200001482 Jodi O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 3.2 {1-chloro-2,4-dinitrobenzene} <31> 3.2 mM 1-chloro-2,4-dinitrobenzene CHEBI:34718 5.3.99.2 Y Y ECO:0000033 Pubmed:11672424 BRENDA <31> Jowsey, I.R.; Thomson, A.M.; Flanagan, J.U.; Murdock, P.R.; Moore,G.B.T.; Meyer, D.J.; Murphy, G.J.; Smith, S.A.; Hayes, J.D.: Mammalianclass Sigma glutathione S-transferases: catalytic properties andtissue-specific expression of human and rat GSH-dependent prostaglandinD2 synthases. Biochem. J. (2001) 359, 507-516. {Pubmed:11672424} AAP, ASD 12/7/2011 1111 2200001483 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.1 {(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate} (#2# in the presence of 0.3 mM dodecylmaltoside <14>) <14> 0.01 mM prostaglandin H2 CHEBI:15554 5.3.99.3 #2# in the presence of 0.3 mM dodecylmaltoside <14> Y Y ECO:0000006 Pubmed:12460774 BRENDA <14> Ouellet, M.; Falgueyret, J.P.; Ear, P.H.; Pen, A.; Mancini, J.A.;Riendeau, D.; David Percival, M.: Purification and characterization ofrecombinant microsomal prostaglandin E synthase-1. Protein Expr. Purif.(2002) 26, 489-495. {Pubmed:12460774}; PENTACON Notes: corrected value AAP, DGA 12/7/2011 1111 2200001484 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.014 {(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate} <14> 0.014 mM prostaglandin H2 CHEBI:15554 5.3.99.3 Y Y ECO:0000006 Pubmed:12460774 BRENDA <14> Ouellet, M.; Falgueyret, J.P.; Ear, P.H.; Pen, A.; Mancini, J.A.;Riendeau, D.; David Percival, M.: Purification and characterization ofrecombinant microsomal prostaglandin E synthase-1. Protein Expr. Purif.(2002) 26, 489-495. {Pubmed:12460774} AAP, DGA 12/7/2011 1111 2200001485 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #12# 0.75 {glutathione} <14> 0.75 mM glutathione CHEBI:16856 5.3.99.3 Y Y ECO:0000006 Pubmed:12460774 BRENDA <14> Ouellet, M.; Falgueyret, J.P.; Ear, P.H.; Pen, A.; Mancini, J.A.;Riendeau, D.; David Percival, M.: Purification and characterization ofrecombinant microsomal prostaglandin E synthase-1. Protein Expr. Purif.(2002) 26, 489-495. {Pubmed:12460774} AAP, DGA 12/7/2011 1111 2200001486 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.6 {glutathione} (#2# in the presence of 0.3 mM dodecylmaltoside<14>) <14> 0.6 mM glutathione CHEBI:16856 5.3.99.3 #2# in the presence of 0.3 mM dodecylmaltoside<14> Y Y ECO:0000006 Pubmed:12460774 BRENDA <14> Ouellet, M.; Falgueyret, J.P.; Ear, P.H.; Pen, A.; Mancini, J.A.;Riendeau, D.; David Percival, M.: Purification and characterization ofrecombinant microsomal prostaglandin E synthase-1. Protein Expr. Purif.(2002) 26, 489-495. {Pubmed:12460774} AAP, DGA 12/7/2011 1111 2200001487 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 5.5 umol/min/mg no detergent and 2.5mM GSH. 5.5 umol/min/mg glutathione CHEBI:16856 prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 Pubmed:12460774 PENTACON Added by PENTACON; PENTACON Notes: no detergent AAP, DGA 4/21/2014 3 2200001488 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 5.5 umol/min/mg no detergent and 20uM PGH2 5.5 umol/min/mg glutathione CHEBI:16856 prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 Pubmed:12460774 PENTACON Added by PENTACON; PENTACON Notes: no detergent AAP, DGA 4/21/2014 3 2200001489 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 38.6 umol/min/mg in the presence of 0.3 mM dodecylmaltoside and 20uM PGH2 38.6 umol/min/mg glutathione CHEBI:16856 prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 Pubmed:12460774 PENTACON Added by PENTACON; PENTACON Notes: in the presence of 0.3 mM dodecylmaltoside AAP, DGA 4/21/2014 3 2200001490 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 46 umol/min/mg in the presence of 0.3 mM dodecylmaltoside and 2.5mM GSH. 46.0 umol/min/mg glutathione CHEBI:16856 prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 Pubmed:12460774 PENTACON Added by PENTACON; PENTACON Notes: in the presence of 0.3 mM dodecylmaltoside AAP, DGA 4/21/2014 3 2200001491 Christie O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.71 {glutathione} <12> 0.71 mM glutathione CHEBI:16856 5.3.99.3 Y Y ECO:0000006 Pubmed:12672824 BRENDA <12> Thoren, S.; Weinander, R.; Saha, S.; Jegerschoeld, C.; Pettersson,P.L.; Samuelsson, B.; Hebert, H.; Hamberg, M.; Morgenstern, R.;Jakobsson, P.J.: Human microsomal prostaglandin E synthase-1:purification, functional characterization, and projection structuredetermination. J. Biol. Chem. (2003) 278, 22199-22209. {Pubmed:12672824} AAP, DGA 12/7/2011 1111 2200001492 Christie O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.16 {prostaglandin G2} <12,25> 0.16 mM prostaglandin G2 CHEBI:27647 5.3.99.3 Y Y ECO:0000006 Pubmed:12672824 BRENDA <12> Thoren, S.; Weinander, R.; Saha, S.; Jegerschoeld, C.; Pettersson,P.L.; Samuelsson, B.; Hebert, H.; Hamberg, M.; Morgenstern, R.;Jakobsson, P.J.: Human microsomal prostaglandin E synthase-1:purification, functional characterization, and projection structuredetermination. J. Biol. Chem. (2003) 278, 22199-22209. {Pubmed:12672824} AAP, DGA 12/7/2011 1111 2200001493 Christie/Rose O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.16 {(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate} <12> 0.16 mM prostaglandin H2 CHEBI:15554 5.3.99.3 Y Y ECO:0000006 Pubmed:12672824 BRENDA <12> Thoren, S.; Weinander, R.; Saha, S.; Jegerschoeld, C.; Pettersson,P.L.; Samuelsson, B.; Hebert, H.; Hamberg, M.; Morgenstern, R.;Jakobsson, P.J.: Human microsomal prostaglandin E synthase-1:purification, functional characterization, and projection structuredetermination. J. Biol. Chem. (2003) 278, 22199-22209. {Pubmed:12672824} AAP, DGA 12/7/2011 1111 2200001494 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 1.3 {H2O2} (#3# pH 8.0, 23°C, wild-type enzyme <45>) <45> 1.3 mM hydrogen peroxide CHEBI:16240 1.14.99.1 #3# pH 8.0, 23°C, wild-type enzyme <45> Y Y ECO:0000006 Pubmed:14625295 BRENDA <45> Bambai, B.; Rogge, C.E.; Stec, B.; Kulmacz, R.J.: Role of Asn-382and Thr-383 in activation and inactivation of human prostaglandin Hsynthase cyclooxygenase catalysis. J. Biol. Chem. (2004) 279,4084-4092. {Pubmed:14625295} (c) AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001495 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 5.5 {H2O2} (#3# pH 8.0, 23°C, mutant enzyme N382L <45>) <45> 5.5 mM hydrogen peroxide CHEBI:16240 1.14.99.1 #3# pH 8.0, 23°C, mutant enzyme N382L <45> Y Y ECO:0000006 Pubmed:14625295 BRENDA <45> Bambai, B.; Rogge, C.E.; Stec, B.; Kulmacz, R.J.: Role of Asn-382and Thr-383 in activation and inactivation of human prostaglandin Hsynthase cyclooxygenase catalysis. J. Biol. Chem. (2004) 279,4084-4092. {Pubmed:14625295} (c) AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001496 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.08 {Guaiacol} (#3# pH 8.0, 23°C, wild-type enzyme <45>) <45> 0.08 mM guaiacol CHEBI:28591 1.14.99.1 #3# pH 8.0, 23°C, wild-type enzyme <45> Y Y ECO:0000006 Pubmed:14625295 BRENDA <45> Bambai, B.; Rogge, C.E.; Stec, B.; Kulmacz, R.J.: Role of Asn-382and Thr-383 in activation and inactivation of human prostaglandin Hsynthase cyclooxygenase catalysis. J. Biol. Chem. (2004) 279,4084-4092. {Pubmed:14625295} (c) AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001497 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.29 {Guaiacol} (#3# pH 8.0, 23°C, mutant enzyme N382L <45>) <45> 0.29 mM guaiacol CHEBI:28591 1.14.99.1 #3# pH 8.0, 23°C, mutant enzyme N382L <45> Y Y ECO:0000006 Pubmed:14625295 BRENDA <45> Bambai, B.; Rogge, C.E.; Stec, B.; Kulmacz, R.J.: Role of Asn-382and Thr-383 in activation and inactivation of human prostaglandin Hsynthase cyclooxygenase catalysis. J. Biol. Chem. (2004) 279,4084-4092. {Pubmed:14625295} (c) AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001498 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0021 {arachidonate} (#3# native enzyme <43>; #3# pH 7.2, 30°C,mutant enzyme N382L <45>; #3# pH 7.2, 30°C, PGHS-2 wild-type enzyme<45>) <43,45> 0.0021 mM arachidonate CHEBI:32395 1.14.99.1 #3# native enzyme <43>; #3# pH 7.2, 30°C,mutant enzyme N382L <45>; #3# pH 7.2, 30°C, PGHS-2 wild-type enzyme<45> Y Y ECO:0000006 Pubmed:14625295 BRENDA <45> Bambai, B.; Rogge, C.E.; Stec, B.; Kulmacz, R.J.: Role of Asn-382and Thr-383 in activation and inactivation of human prostaglandin Hsynthase cyclooxygenase catalysis. J. Biol. Chem. (2004) 279,4084-4092. {Pubmed:14625295} (c) AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001499 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0022 {arachidonate} (#3# pH 7.2, 30°C, mutant enzyme N383D<45>) <45> 0.0022 mM arachidonate CHEBI:32395 1.14.99.1 #3# pH 7.2, 30°C, mutant enzyme N383D<45> Y Y ECO:0000006 Pubmed:14625295 BRENDA <45> Bambai, B.; Rogge, C.E.; Stec, B.; Kulmacz, R.J.: Role of Asn-382and Thr-383 in activation and inactivation of human prostaglandin Hsynthase cyclooxygenase catalysis. J. Biol. Chem. (2004) 279,4084-4092. {Pubmed:14625295} (c); PENTACON Notes: Mutant: N383D mutant is really T383D AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001500 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0029 {arachidonate} (#3# pH 7.2, 30°C, mutant enzyme N382D<45>) <45> 0.0029 mM arachidonate CHEBI:32395 1.14.99.1 #3# pH 7.2, 30°C, mutant enzyme N382D<45> Y Y ECO:0000006 Pubmed:14625295 BRENDA <45> Bambai, B.; Rogge, C.E.; Stec, B.; Kulmacz, R.J.: Role of Asn-382and Thr-383 in activation and inactivation of human prostaglandin Hsynthase cyclooxygenase catalysis. J. Biol. Chem. (2004) 279,4084-4092. {Pubmed:14625295} (c) AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001501 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0041 {arachidonate} (#3# pH 7.2, 30°C, mutant enzyme N382A<45>) <45> 0.0041 mM arachidonate CHEBI:32395 1.14.99.1 #3# pH 7.2, 30°C, mutant enzyme N382A<45> Y Y ECO:0000006 Pubmed:14625295 BRENDA <45> Bambai, B.; Rogge, C.E.; Stec, B.; Kulmacz, R.J.: Role of Asn-382and Thr-383 in activation and inactivation of human prostaglandin Hsynthase cyclooxygenase catalysis. J. Biol. Chem. (2004) 279,4084-4092. {Pubmed:14625295} (c) AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001502 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0083 {N,N,N',N'-tetramethyl-p-phenylenediamine} (#3# pH 7.2,30°C, mutant enzyme N383H <45>) <45> 0.0083 mM N,N,N',N'-tetramethyl-p-phenylenediamine CHEBI:NONE_148504 1.14.99.1 #3# pH 7.2,30°C, mutant enzyme N383H <45> Y Y ECO:0000006 Pubmed:14625295 BRENDA <45> Bambai, B.; Rogge, C.E.; Stec, B.; Kulmacz, R.J.: Role of Asn-382and Thr-383 in activation and inactivation of human prostaglandin Hsynthase cyclooxygenase catalysis. J. Biol. Chem. (2004) 279,4084-4092. {Pubmed:14625295} (c); PENTACON Notes: Request ChEBI ID: N,N,N',N'-tetramethyl-p-phenylenediamine; Mutant: N383H mutant is really T383H AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001503 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.01 {N,N,N',N'-tetramethyl-p-phenylenediamine} (#3# pH 7.2,30°C, mutant enzyme N383D <45>) <45> 0.01 mM N,N,N',N'-tetramethyl-p-phenylenediamine CHEBI:NONE_148504 1.14.99.1 #3# pH 7.2,30°C, mutant enzyme N383D <45> Y Y ECO:0000006 Pubmed:14625295 BRENDA <45> Bambai, B.; Rogge, C.E.; Stec, B.; Kulmacz, R.J.: Role of Asn-382and Thr-383 in activation and inactivation of human prostaglandin Hsynthase cyclooxygenase catalysis. J. Biol. Chem. (2004) 279,4084-4092. {Pubmed:14625295} (c); PENTACON Notes: Request ChEBI ID: N,N,N',N'-tetramethyl-p-phenylenediamine; Mutant: N383D mutant is really T383D AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001504 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0156 {N,N,N',N'-tetramethyl-p-phenylenediamine} (#3# pH 7.2,30°C, mutant enzyme N382D <45>) <45> 0.0156 mM N,N,N',N'-tetramethyl-p-phenylenediamine CHEBI:NONE_148504 1.14.99.1 #3# pH 7.2,30°C, mutant enzyme N382D <45> Y Y ECO:0000006 Pubmed:14625295 BRENDA <45> Bambai, B.; Rogge, C.E.; Stec, B.; Kulmacz, R.J.: Role of Asn-382and Thr-383 in activation and inactivation of human prostaglandin Hsynthase cyclooxygenase catalysis. J. Biol. Chem. (2004) 279,4084-4092. {Pubmed:14625295} (c); PENTACON Notes: Request ChEBI ID: N,N,N',N'-tetramethyl-p-phenylenediamine AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001505 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0163 {N,N,N',N'-tetramethyl-p-phenylenediamine} (#3# pH 7.2,30°C, PGHS-2 wild-type enzyme <45>) <45> 0.0163 mM N,N,N',N'-tetramethyl-p-phenylenediamine CHEBI:NONE_148504 1.14.99.1 #3# pH 7.2,30°C, PGHS-2 wild-type enzyme <45> Y Y ECO:0000006 Pubmed:14625295 BRENDA <45> Bambai, B.; Rogge, C.E.; Stec, B.; Kulmacz, R.J.: Role of Asn-382and Thr-383 in activation and inactivation of human prostaglandin Hsynthase cyclooxygenase catalysis. J. Biol. Chem. (2004) 279,4084-4092. {Pubmed:14625295} (c); PENTACON Notes: Request ChEBI ID: N,N,N',N'-tetramethyl-p-phenylenediamine AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001506 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0854 {N,N,N',N'-tetramethyl-p-phenylenediamine} (#3# pH 7.2,30°C, mutant enzyme N382L <45>) <45> 0.0854 mM N,N,N',N'-tetramethyl-p-phenylenediamine CHEBI:NONE_148504 1.14.99.1 #3# pH 7.2,30°C, mutant enzyme N382L <45> Y Y ECO:0000006 Pubmed:14625295 BRENDA <45> Bambai, B.; Rogge, C.E.; Stec, B.; Kulmacz, R.J.: Role of Asn-382and Thr-383 in activation and inactivation of human prostaglandin Hsynthase cyclooxygenase catalysis. J. Biol. Chem. (2004) 279,4084-4092. {Pubmed:14625295} (c); PENTACON Notes: Request ChEBI ID: N,N,N',N'-tetramethyl-p-phenylenediamine AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001507 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0021 {arachidonate} (#3# native enzyme <43>) <43> 0.0021 mM arachidonate CHEBI:32395 1.14.99.1 #3# native enzyme <43> Y Y ECO:0000006 Pubmed:14769032 BRENDA <43> Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai,A.L.: Identification of Tyr504 as an alternative tyrosyl radical sitein human prostaglandin H synthase-2. Biochemistry (2004) 43, 1560-1568.{Pubmed:14769032} (c) AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001508 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0032 {arachidonate} (#3# mutant enzyme Y148F <43>) <43> 0.0032 mM arachidonate CHEBI:32395 1.14.99.1 #3# mutant enzyme Y148F <43> Y Y ECO:0000006 Pubmed:14769032 BRENDA <43> Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai,A.L.: Identification of Tyr504 as an alternative tyrosyl radical sitein human prostaglandin H synthase-2. Biochemistry (2004) 43, 1560-1568.{Pubmed:14769032} (c); PENTACON Notes: Mutant: Y148F AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001509 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0036 {arachidonate} (#3# mutant enzyme Y404F <43>) <43> 0.0036 mM arachidonate CHEBI:32395 1.14.99.1 #3# mutant enzyme Y404F <43> Y Y ECO:0000006 Pubmed:14769032 BRENDA <43> Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai,A.L.: Identification of Tyr504 as an alternative tyrosyl radical sitein human prostaglandin H synthase-2. Biochemistry (2004) 43, 1560-1568.{Pubmed:14769032} (c); PENTACON Notes: Mutant: Y404F AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001510 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0038 {arachidonate} (#3# mutant enzyme Y348F <43>) <43> 0.0038 mM arachidonate CHEBI:32395 1.14.99.1 #3# mutant enzyme Y348F <43> Y Y ECO:0000006 Pubmed:14769032 BRENDA <43> Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai,A.L.: Identification of Tyr504 as an alternative tyrosyl radical sitein human prostaglandin H synthase-2. Biochemistry (2004) 43, 1560-1568.{Pubmed:14769032} (c); PENTACON Notes: Mutant: Y348F AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001511 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0042 {arachidonate} (#3# mutant enzyme Y504F <43>) <43> 0.0042 mM arachidonate CHEBI:32395 1.14.99.1 #3# mutant enzyme Y504F <43> Y Y ECO:0000006 Pubmed:14769032 BRENDA <43> Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai,A.L.: Identification of Tyr504 as an alternative tyrosyl radical sitein human prostaglandin H synthase-2. Biochemistry (2004) 43, 1560-1568.{Pubmed:14769032} (c); PENTACON Notes: Mutant: Y504F AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001512 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0043 {arachidonate} (#3# mutant enzyme Y148F/Y348F/Y404F/Y504F<43>) <43> 0.0043 mM arachidonate CHEBI:32395 1.14.99.1 #3# mutant enzyme Y148F/Y348F/Y404F/Y504F<43> Y Y ECO:0000006 Pubmed:14769032 BRENDA <43> Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai,A.L.: Identification of Tyr504 as an alternative tyrosyl radical sitein human prostaglandin H synthase-2. Biochemistry (2004) 43, 1560-1568.{Pubmed:14769032} (c); PENTACON Notes: Mutant: Y148F/Y348F/Y404F/Y504F AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001513 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.02 {trans-5-phenyl-4-pentenyl-1-hydroperoxide} (#3# mutantenzyme Y148F <43>) <43> 0.02 mM trans-5-phenyl-4-pentenyl-1-hydroperoxide CHEBI:NONE_148505 1.14.99.1 #3# mutantenzyme Y148F <43> Y Y ECO:0000006 Pubmed:14769032 BRENDA <43> Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai,A.L.: Identification of Tyr504 as an alternative tyrosyl radical sitein human prostaglandin H synthase-2. Biochemistry (2004) 43, 1560-1568.{Pubmed:14769032} (c); PENTACON Notes: Mutant: Y148F; Request ChEBI ID: trans-5-phenyl-4-pentenyl-1-hydroperoxide, PubChem ID: CID 6438577 AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001514 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.061 {trans-5-phenyl-4-pentenyl-1-hydroperoxide} (#3# mutantenzyme Y404F <43>) <43> 0.061 mM trans-5-phenyl-4-pentenyl-1-hydroperoxide CHEBI:NONE_148505 1.14.99.1 #3# mutantenzyme Y404F <43> Y Y ECO:0000006 Pubmed:14769032 BRENDA <43> Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai,A.L.: Identification of Tyr504 as an alternative tyrosyl radical sitein human prostaglandin H synthase-2. Biochemistry (2004) 43, 1560-1568.{Pubmed:14769032} (c); PENTACON Notes: Request ChEBI ID: trans-5-phenyl-4-pentenyl-1-hydroperoxide, PubChem ID: CID 6438577 AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001515 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.072 {trans-5-phenyl-4-pentenyl-1-hydroperoxide} (#3# mutantenzyme Y348F <43>) <43> 0.072 mM trans-5-phenyl-4-pentenyl-1-hydroperoxide CHEBI:NONE_148505 1.14.99.1 #3# mutantenzyme Y348F <43> Y Y ECO:0000006 Pubmed:14769032 BRENDA <43> Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai,A.L.: Identification of Tyr504 as an alternative tyrosyl radical sitein human prostaglandin H synthase-2. Biochemistry (2004) 43, 1560-1568.{Pubmed:14769032} (c); PENTACON Notes: Mutant:Y348F; Request ChEBI ID: trans-5-phenyl-4-pentenyl-1-hydroperoxide, PubChem ID: CID 6438577 AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001516 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.103 {trans-5-phenyl-4-pentenyl-1-hydroperoxide} (#3# mutantenzyme Y148F/Y348F/Y385F/Y404F/Y504F <43>) <43> 0.103 mM trans-5-phenyl-4-pentenyl-1-hydroperoxide CHEBI:NONE_148505 1.14.99.1 #3# mutantenzyme Y148F/Y348F/Y385F/Y404F/Y504F <43> Y Y ECO:0000006 Pubmed:14769032 BRENDA <43> Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai,A.L.: Identification of Tyr504 as an alternative tyrosyl radical sitein human prostaglandin H synthase-2. Biochemistry (2004) 43, 1560-1568.{Pubmed:14769032} (c); PENTACON Notes: Mutant:Y148F/Y348F/Y385F/Y404F/Y504F; Request ChEBI ID: trans-5-phenyl-4-pentenyl-1-hydroperoxide, PubChem ID: CID 6438577 AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001517 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.138 {trans-5-phenyl-4-pentenyl-1-hydroperoxide} (#3# nativeenzyme <43>) <43> 0.138 mM trans-5-phenyl-4-pentenyl-1-hydroperoxide CHEBI:NONE_148505 1.14.99.1 #3# nativeenzyme <43> Y Y ECO:0000006 Pubmed:14769032 BRENDA <43> Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai,A.L.: Identification of Tyr504 as an alternative tyrosyl radical sitein human prostaglandin H synthase-2. Biochemistry (2004) 43, 1560-1568.{Pubmed:14769032} (c); PENTACON Notes: Request ChEBI ID: trans-5-phenyl-4-pentenyl-1-hydroperoxide, PubChem ID: CID 6438577 AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001518 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.339 {trans-5-phenyl-4-pentenyl-1-hydroperoxide} (#3# mutantenzyme Y385F <43>) <43> 0.339 mM trans-5-phenyl-4-pentenyl-1-hydroperoxide CHEBI:NONE_148505 1.14.99.1 #3# mutantenzyme Y385F <43> Y Y ECO:0000006 Pubmed:14769032 BRENDA <43> Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai,A.L.: Identification of Tyr504 as an alternative tyrosyl radical sitein human prostaglandin H synthase-2. Biochemistry (2004) 43, 1560-1568.{Pubmed:14769032} (c); PENTACON Notes: Mutant: Y385F; Request ChEBI ID: trans-5-phenyl-4-pentenyl-1-hydroperoxide, PubChem ID: CID 6438577 AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001519 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.37 {trans-5-phenyl-4-pentenyl-1-hydroperoxide} (#3# mutantenzyme Y148F/Y348F/Y404F/Y504F <43>) <43> 0.37 mM trans-5-phenyl-4-pentenyl-1-hydroperoxide CHEBI:NONE_148505 1.14.99.1 #3# mutantenzyme Y148F/Y348F/Y404F/Y504F <43> Y Y ECO:0000006 Pubmed:14769032 BRENDA <43> Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai,A.L.: Identification of Tyr504 as an alternative tyrosyl radical sitein human prostaglandin H synthase-2. Biochemistry (2004) 43, 1560-1568.{Pubmed:14769032} (c); PENTACON Notes: Mutant: Y148F/Y348F/Y404F/Y504F; Request ChEBI ID: trans-5-phenyl-4-pentenyl-1-hydroperoxide, PubChem ID: CID 6438577 AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001520 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.437 {trans-5-phenyl-4-pentenyl-1-hydroperoxide} (#3# mutantenzyme Y504F <43>) <43> 0.437 mM trans-5-phenyl-4-pentenyl-1-hydroperoxide CHEBI:NONE_148505 1.14.99.1 #3# mutantenzyme Y504F <43> Y Y ECO:0000006 Pubmed:14769032 BRENDA <43> Rogge, C.E.; Liu, W.; Wu, G.; Wang, L.H.; Kulmacz, R.J.; Tsai,A.L.: Identification of Tyr504 as an alternative tyrosyl radical sitein human prostaglandin H synthase-2. Biochemistry (2004) 43, 1560-1568.{Pubmed:14769032} (c); PENTACON Notes: Mutant: Y504F; Request ChEBI ID: trans-5-phenyl-4-pentenyl-1-hydroperoxide, PubChem ID: CID 6438577 AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001521 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.24 {prostaglandin E2} (#6# form CR2 <16>) <16> 0.24 mM prostaglandin E2 CHEBI:15551 1.1.1.184 #6# form CR2 <16> Y Y ECO:0000006 Pubmed:1540623 BRENDA <16> Inazu, N.; Ruepp, B.; Wirth, H.; Wermuth, B.: Carbonyl reductasefrom human testis: purification and comparison with carbonyl reductasefrom human brain and rat testis. Biochim. Biophys. Acta (1992) 1116,50-56. {Pubmed:1540623}; PENTACON Notes: Tissue: Testis AAP, ASD 12/7/2011 1111 2200001522 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.15 {5alpha-androstane-3,17-dione} (#6# form CR2 <16>) <16> 0.15 mM 5alpha-androstane-3,17-dione CHEBI:15994 1.1.1.184 #6# form CR2 <16> Y Y ECO:0000006 Pubmed:1540623 BRENDA <16> Inazu, N.; Ruepp, B.; Wirth, H.; Wermuth, B.: Carbonyl reductasefrom human testis: purification and comparison with carbonyl reductasefrom human brain and rat testis. Biochim. Biophys. Acta (1992) 1116,50-56. {Pubmed:1540623}; PENTACON Notes: Tissue: Testis AAP, ASD 12/7/2011 1111 2200001523 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.14-0.21 {Prostaglandin B2} (#6# Km depending on enzyme form<16>) <16> mM prostaglandin B2 CHEBI:28099 1.1.1.184 #6# Km depending on enzyme form<16> Y Y ECO:0000006 Pubmed:1540623 BRENDA <16> Inazu, N.; Ruepp, B.; Wirth, H.; Wermuth, B.: Carbonyl reductasefrom human testis: purification and comparison with carbonyl reductasefrom human brain and rat testis. Biochim. Biophys. Acta (1992) 1116,50-56. {Pubmed:1540623}; PENTACON Notes: Tissue: Testis AAP, ASD 12/7/2011 1111 2200001524 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.3-2.5 {4-Nitroacetophenone} (#6# Km depending on enzyme form<16>) <16> mM 4-nitroacetophenone CHEBI:28735 1.1.1.184 #6# Km depending on enzyme form<16> Y Y ECO:0000006 Pubmed:1540623 BRENDA <16> Inazu, N.; Ruepp, B.; Wirth, H.; Wermuth, B.: Carbonyl reductasefrom human testis: purification and comparison with carbonyl reductasefrom human brain and rat testis. Biochim. Biophys. Acta (1992) 1116,50-56. {Pubmed:1540623}; PENTACON Notes: Tissue: Testis AAP, ASD 12/7/2011 1111 2200001525 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.05-0.07 {menadione} (#6# Km depending on enzyme form <16>) <16> mM menadione CHEBI:28869 1.1.1.184 #6# Km depending on enzyme form <16> Y Y ECO:0000006 Pubmed:1540623 BRENDA <16> Inazu, N.; Ruepp, B.; Wirth, H.; Wermuth, B.: Carbonyl reductasefrom human testis: purification and comparison with carbonyl reductasefrom human brain and rat testis. Biochim. Biophys. Acta (1992) 1116,50-56.{Pubmed:1540623}; PENTACON Notes: Tissue: Testis AAP, ASD 12/7/2011 1111 2200001526 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.3-1.6 {4-Nitrobenzaldehyde} (#6# Km depending on enzyme form<16>) <16> mM 4-nitrobenzaldehyde CHEBI:66926 1.1.1.184 #6# Km depending on enzyme form<16> Y Y ECO:0000006 Pubmed:1540623 BRENDA <16> Inazu, N.; Ruepp, B.; Wirth, H.; Wermuth, B.: Carbonyl reductasefrom human testis: purification and comparison with carbonyl reductasefrom human brain and rat testis. Biochim. Biophys. Acta (1992) 1116,50-56. {Pubmed:1540623}; PENTACON Notes: Tissue: Testis AAP, ASD 12/7/2011 1111 2200001527 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.31-0.45 {4-benzoylpyridine} (#6# Km depending on enzyme form<16>) <16> mM 4-benzoylpyridine CHEBI:NONE_148506 1.1.1.184 #6# Km depending on enzyme form<16> Y Y ECO:0000006 Pubmed:1540623 BRENDA <16> Inazu, N.; Ruepp, B.; Wirth, H.; Wermuth, B.: Carbonyl reductasefrom human testis: purification and comparison with carbonyl reductasefrom human brain and rat testis. Biochim. Biophys. Acta (1992) 1116,50-56. {Pubmed:1540623}; PENTACON Notes: Tissue: Testis; Request ChEBI ID: 4-benzoylpyridine, PubChem ID: CID 26731 AAP, ASD 12/7/2011 1111 2200001528 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.38-0.65 {4-carboxybenzaldehde} (#6# Km depending on enzyme form<16>) <16> mM 4-carboxybenzaldehde CHEBI:NONE_148507 1.1.1.184 #6# Km depending on enzyme form<16> Y Y ECO:0000006 Pubmed:1540623 BRENDA <16> Inazu, N.; Ruepp, B.; Wirth, H.; Wermuth, B.: Carbonyl reductasefrom human testis: purification and comparison with carbonyl reductasefrom human brain and rat testis. Biochim. Biophys. Acta (1992) 1116,50-56. {Pubmed:1540623}; PENTACON Notes: Tissue: Testis; Request ChEBI ID: 4-Carboxybenzaldehyde, Pubchem ID: CID 12088 AAP, ASD 12/7/2011 1111 2200001529 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.49-2 {pyridine-4-carboxaldehyde} (#6# Km depending on enzymeform <16>) <16> mM pyridine-4-carboxaldehyde CHEBI:NONE_148508 1.1.1.184 #6# Km depending on enzymeform <16> Y Y ECO:0000006 Pubmed:1540623 BRENDA <16> Inazu, N.; Ruepp, B.; Wirth, H.; Wermuth, B.: Carbonyl reductasefrom human testis: purification and comparison with carbonyl reductasefrom human brain and rat testis. Biochim. Biophys. Acta (1992) 1116,50-56. {Pubmed:1540623}; PENTACON Notes: Tissue: Testis; Request ChEBI ID: Pyridine4-carboxaldehyde, PubChem ID: CID 13389 AAP, ASD 12/7/2011 1111 2200001530 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.34 {prostaglandin E2} (#6# form CR8 <16>) <16> 0.34 mM prostaglandin E2 CHEBI:15551 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain AAP, ASD 4/21/2014 3 2200001531 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.08 {5alpha-androstane-3,17-dione} (#6# form CR8 <16>) <16> 0.08 mM 5alpha-androstane-3,17-dione CHEBI:15994 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain AAP, ASD 4/21/2014 3 2200001532 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.03 {5alpha-androstan-17beta-ol-3-one} (#6# form CR8 <16>) <16> 0.03 mM 17beta-hydroxy-5alpha-androstan-3-one CHEBI:16330 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain AAP, ASD 4/21/2014 3 2200001533 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.05 {5alpha-androstan-17beta-ol-3-one} (#6# form CR2 <16>) <16> 0.05 mM 17beta-hydroxy-5alpha-androstan-3-one CHEBI:16330 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Testis AAP, ASD 4/21/2014 3 2200001534 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.33 {prostaglandin B2} (#6# form CR8 <16>) <16> 0.33 mM prostaglandin B2 CHEBI:28099 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain AAP, ASD 4/21/2014 3 2200001535 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.39 {prostaglandin B2} (#6# form CR2 <16>) <16> 0.39 mM prostaglandin B2 CHEBI:28099 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Testis AAP, ASD 4/21/2014 3 2200001536 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.16-0.51 {Prostaglandin B2} (#6# Km depending on enzyme form<16>) <16> mM prostaglandin B2 CHEBI:28099 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain AAP, ASD 4/21/2014 3 2200001537 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.9 {4-nitroacetophenone} (#6# form CR8 <16>) <16> 1.9 mM 4-nitroacetophenone CHEBI:28735 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain AAP, ASD 4/21/2014 3 2200001538 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 2.5 {4-nitroacetophenone} (#6# form CR2 <16>) <16> 2.5 mM 4-nitroacetophenone CHEBI:28735 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Testis AAP, ASD 4/21/2014 3 2200001539 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.9-2.7 {4-Nitroacetophenone} (#6# Km depending on enzyme form<16>) <16> mM 4-nitroacetophenone CHEBI:28735 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain AAP, ASD 4/21/2014 3 2200001540 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.07 {menadione} (#6# form CR2 <16>) <16> 0.07 mM menadione CHEBI:28869 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Testis AAP, ASD 4/21/2014 3 2200001541 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.07 {menadione} (#6# form CR8 <16>) <16> 0.07 mM menadione CHEBI:28869 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain AAP, ASD 4/21/2014 3 2200001542 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.05-0.07 {menadione} (#6# Km depending on enzyme form <16>) <16> mM menadione CHEBI:28869 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain AAP, ASD 4/21/2014 3 2200001543 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.5 {4-nitrobenzaldehyde} (#6# form CR2 <16>) <16> 1.5 mM 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Testis AAP, ASD 4/21/2014 3 2200001544 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 2.0 {4-nitrobenzaldehyde} (#6# form CR8 <16>) <16> 2.0 mM 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain AAP, ASD 4/21/2014 3 2200001545 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.9-2.1 {4-Nitrobenzaldehyde} (#6# Km depending on enzyme form<16>) <16> mM 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain AAP, ASD 4/21/2014 3 2200001546 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.31 {4-benzoylpyridine} (#6# form CR2 <16>) <16> 0.31 mM 4-benzoylpyridine CHEBI:NONE_148506 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Testis; Request ChEBI ID: 4-benzoylpyridine, PubChem ID: CID 26731 AAP, ASD 4/21/2014 3 2200001547 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.32 {4-benzoylpyridine} (#6# form CR8 <16>) <16> 0.32 mM 4-benzoylpyridine CHEBI:NONE_148506 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain; Request ChEBI ID: 4-benzoylpyridine, PubChem ID: CID 26731 AAP, ASD 4/21/2014 3 2200001548 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.32-0.44 {4-benzoylpyridine} (#6# Km depending on enzyme form<16>) <16> mM 4-benzoylpyridine CHEBI:NONE_148506 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain; Request ChEBI ID: 4-benzoylpyridine, PubChem ID: CID 26731 AAP, ASD 4/21/2014 3 2200001549 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.54-1.37 {4-carboxybenzaldehde} (#6# Km depending on enzyme form<16>) <16> mM 4-carboxybenzaldehde CHEBI:NONE_148507 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain; Request ChEBI ID: 4-Carboxybenzaldehyde, Pubchem ID: CID 12088 AAP, ASD 4/21/2014 3 2200001550 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.4 {4-Carboxybenzaldehyde} (#6# form CR2 <16>) <16> 0.4 mM 4-Carboxybenzaldehyde CHEBI:NONE_148509 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Testis; Request ChEBI ID: 4-Carboxybenzaldehyde, Pubchem ID: CID 12088 AAP, ASD 4/21/2014 3 2200001551 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.37 {4-Carboxybenzaldehyde} (#6# form CR8 <16>) <16> 1.37 mM 4-Carboxybenzaldehyde CHEBI:NONE_148509 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain; Request ChEBI ID: 4-Carboxybenzaldehyde, Pubchem ID: CID 12088 AAP, ASD 4/21/2014 3 2200001552 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.2-2.8 {pyridine-4-carboxaldehyde} (#6# Km depending on enzymeform <16>) <16> mM pyridine-4-carboxaldehyde CHEBI:NONE_148508 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain; Request ChEBI ID: Pyridine4-carboxaldehyde, PubChem ID: CID 13389 AAP, ASD 4/21/2014 3 2200001553 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.49 {Pyridine4-carboxaldehyde} (#6# form CR2 <16>) <16> 0.49 mM Pyridine4-carboxaldehyde CHEBI:NONE_148510 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Testis; Request ChEBI ID: Pyridine4-carboxaldehyde, PubChem ID: CID 13389 AAP, ASD 4/21/2014 3 2200001554 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.2 {Pyridine4-carboxaldehyde} (#6# form CR8 <16>) <16> 1.2 mM Pyridine4-carboxaldehyde CHEBI:NONE_148510 Y Y ECO:0000006 Pubmed:1540623 PENTACON Added by PENTACON; PENTACON Notes: Tissue: Brain; Request ChEBI ID: Pyridine4-carboxaldehyde, PubChem ID: CID 13389 AAP, ASD 4/21/2014 3 2200001555 Jodi P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0097 {1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine} (#4# pH 6.0, 30°C <46>) <46> 0.0097 mM 1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine CHEBI:NONE_148511 1.1.1.21 #4# pH 6.0, 30°C <46> Y Y ECO:0000006 Pubmed:15465833 BRENDA <46> Srivastava, S.; Spite, M.; Trent, J.O.; West, M.B.; Ahmed, Y.;Bhatnagar, A.: Aldose reductase-catalyzed reduction of aldehydephospholipids. J. Biol. Chem. (2004) 279, 53395-53406. {Pubmed:15465833}; PENTACON Notes: Request ChEBI ID: 1-palmitoyl-2-(5-oxovaleryl)sn-glycero-3-phosphocholine AAP, DGA, ASD 12/7/2011 1111 2200001556 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.025 {menadione} (#6# pH 7.4, 37°C, recombinant enzyme <33>) <33> 0.025 mM menadione CHEBI:28869 1.1.1.184 #6# pH 7.4, 37°C, recombinant enzyme <33> Y Y ECO:0000006 Pubmed:15476404 BRENDA <33> Doorn, J.A.; Maser, E.; Blum, A.; Claffey, D.J.; Petersen, D.R.:Human carbonyl reductase catalyzes reduction of 4-oxonon-2-enal.Biochemistry (2004) 43, 13106-13114. {Pubmed:15476404} AAP, ASD 12/7/2011 1111 2200001557 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.345 {4-oxonon-2-enal} (#6# pH 7.4, 37°C, recombinant enzyme<33>) <33> 0.345 mM (E)-4-oxonon-2-enal CHEBI:58972 1.1.1.184 #6# pH 7.4, 37°C, recombinant enzyme<33> Y Y ECO:0000006 Pubmed:15476404 BRENDA <33> Doorn, J.A.; Maser, E.; Blum, A.; Claffey, D.J.; Petersen, D.R.:Human carbonyl reductase catalyzes reduction of 4-oxonon-2-enal.Biochemistry (2004) 43, 13106-13114. {Pubmed:15476404} AAP, ASD 12/7/2011 1111 2200001558 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.329 {glutathione-4-oxonon-2-enal} (#6# pH 7.4, 37°C,recombinant enzyme <33>) <33> 0.329 mM glutathione-4-oxonon-2-enal CHEBI:NONE_148512 1.1.1.184 #6# pH 7.4, 37°C,recombinant enzyme <33> Y Y ECO:0000006 Pubmed:15476404 BRENDA <33> Doorn, J.A.; Maser, E.; Blum, A.; Claffey, D.J.; Petersen, D.R.:Human carbonyl reductase catalyzes reduction of 4-oxonon-2-enal.Biochemistry (2004) 43, 13106-13114. {Pubmed:15476404} ; PENTACON Notes: Request ChEBI ID: glutathione-4-oxonon-2-enal AAP, ASD 12/7/2011 1111 2200001559 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 8200 {menadione} (#6# pH 7.4, 37°C, recombinant enzyme <33>) <33> 8200.0 nmol/min/mg menadione CHEBI:28869 Y Y ECO:0000006 Pubmed:15476404 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001560 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 7330 {4-oxonon-2-enal} (#6# pH 7.4, 37°C, recombinant enzyme<33>) <33> 7330.0 nmol/min/mg (E)-4-oxonon-2-enal CHEBI:58972 Y Y ECO:0000006 Pubmed:15476404 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001561 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 214 {glutathione-4-oxonon-2-enal} (#6# pH 7.4, 37°C,recombinant enzyme <33>) <33> 214.0 nmol/min/mg glutathione-4-oxonon-2-enal CHEBI:NONE_148512 Y Y ECO:0000006 Pubmed:15476404 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: glutathione-4-oxonon-2-enal; pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001562 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.085 {NADPH} (#6# pH 7.4, 37°C, recombinant isozyme CBR M244<50>) <50> 0.085 mM NADPH CHEBI:16474 1.1.1.184 #6# pH 7.4, 37°C, recombinant isozyme CBR M244<50> Y Y ECO:0000006 Pubmed:15537833 BRENDA <50> Lakhman, S.S.; Ghosh, D.; Blanco, J.G.: Functional significance ofa natural allelic variant of human carbonyl reductase 3 (CBR3). DrugMetab. Dispos. (2005) 33, 254-257. {Pubmed:15537833}; PENTACON Notes: Isoform: M244 AAP, ASD 12/7/2011 1111 2200001563 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.0905 {NADPH} (#6# pH 7.4, 37°C, recombinant isozyme CBR V244<50>) <50> 0.0905 mM NADPH CHEBI:16474 1.1.1.184 #6# pH 7.4, 37°C, recombinant isozyme CBR V244<50> Y Y ECO:0000006 Pubmed:15537833 BRENDA <50> Lakhman, S.S.; Ghosh, D.; Blanco, J.G.: Functional significance ofa natural allelic variant of human carbonyl reductase 3 (CBR3). DrugMetab. Dispos. (2005) 33, 254-257. {Pubmed:15537833} AAP, ASD 12/7/2011 1111 2200001564 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.0229 {menadione} (#6# pH 7.4, 37°C, recombinant isozyme CBRM244 <50>) <50> 0.0229 mM menadione CHEBI:28869 1.1.1.184 #6# pH 7.4, 37°C, recombinant isozyme CBRM244 <50> Y Y ECO:0000006 Pubmed:15537833 BRENDA <50> Lakhman, S.S.; Ghosh, D.; Blanco, J.G.: Functional significance ofa natural allelic variant of human carbonyl reductase 3 (CBR3). DrugMetab. Dispos. (2005) 33, 254-257. {Pubmed:15537833}; PENTACON Notes: Isoform: M244 AAP, ASD 12/7/2011 1111 2200001565 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.0246 {menadione} (#6# pH 7.4, 37°C, recombinant isozyme CBRV244 <50>) <50> 0.0246 mM menadione CHEBI:28869 1.1.1.184 #6# pH 7.4, 37°C, recombinant isozyme CBRV244 <50> Y Y ECO:0000006 Pubmed:15537833 BRENDA <50> Lakhman, S.S.; Ghosh, D.; Blanco, J.G.: Functional significance ofa natural allelic variant of human carbonyl reductase 3 (CBR3). DrugMetab. Dispos. (2005) 33, 254-257. {Pubmed:15537833} AAP, ASD 12/7/2011 1111 2200001566 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 32400 {NADPH} (#6# pH 7.4, 37°C, recombinant isozyme CBR V244<50>) <50> 32400.0 nmol/min/mg NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:15537833 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001567 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 53000 {NADPH} (#6# pH 7.4, 37°C, recombinant isozyme CBR M244<50>) <50> 53000.0 nmol/min/mg NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:15537833 PENTACON Added by PENTACON; PENTACON Notes: Isoform: M244; pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001568 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 19600 {menadione} (#6# pH 7.4, 37°C, recombinant isozyme CBRV244 <50>) <50> 19600.0 nmol/min/mg menadione CHEBI:28869 Y Y ECO:0000006 Pubmed:15537833 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001569 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 40600 {menadione} (#6# pH 7.4, 37°C, recombinant isozyme CBRM244 <50>) <50> 40600.0 nmol/min/mg menadione CHEBI:28869 Y Y ECO:0000006 Pubmed:15537833 PENTACON Added by PENTACON; PENTACON Notes: Isoform: M244; pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001570 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.02 {DL-glyceraldehyde} (#4# pH 7.0, 25°C, recombinant wild-typeenzyme <59>) <19,59> 0.02 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# pH 7.0, 25°C, recombinant wild-typeenzyme <59> Y Y ECO:0000006 Pubmed:15769597 BRENDA <59> Bohren, K.M.; Brownlee, J.M.; Milne, A.C.; Gabbay, K.H.; Harrison,D.H.: The structure of Apo R268A human aldose reductase: Hinges andlatches that control the kinetic mechanism. Biochim. Biophys. Acta(2005) 1748, 201-212. {Pubmed:15769597} AAP, DGA, ASD 12/7/2011 1111 2200001571 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4,8# 0.03 {DL-glyceraldehyde} (#4# pH 7.0, 25°C, recombinant mutantS226A <59>) <12,59> 0.03 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# pH 7.0, 25°C, recombinant mutantS226A <59> Y Y ECO:0000006 Pubmed:15769597 BRENDA <59> Bohren, K.M.; Brownlee, J.M.; Milne, A.C.; Gabbay, K.H.; Harrison,D.H.: The structure of Apo R268A human aldose reductase: Hinges andlatches that control the kinetic mechanism. Biochim. Biophys. Acta(2005) 1748, 201-212. {Pubmed:15769597}; PENTACON Notes: Mutant: S226A AAP, DGA, ASD 12/7/2011 1111 2200001572 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.05 {DL-glyceraldehyde} (#4# pH 7.0, 25°C, recombinant mutantR268A <59>) <59> 0.05 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# pH 7.0, 25°C, recombinant mutantR268A <59> Y Y ECO:0000006 Pubmed:15769597 BRENDA <59> Bohren, K.M.; Brownlee, J.M.; Milne, A.C.; Gabbay, K.H.; Harrison,D.H.: The structure of Apo R268A human aldose reductase: Hinges andlatches that control the kinetic mechanism. Biochim. Biophys. Acta(2005) 1748, 201-212. {Pubmed:15769597}; PENTACON Notes: Mutant: R268A AAP, DGA, ASD 12/7/2011 1111 2200001573 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.11 {DL-glyceraldehyde} (#4# pH 7.0, 25°C, recombinant mutantS210A <59>) <59> 0.11 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# pH 7.0, 25°C, recombinant mutantS210A <59> Y Y ECO:0000006 Pubmed:15769597 BRENDA <59> Bohren, K.M.; Brownlee, J.M.; Milne, A.C.; Gabbay, K.H.; Harrison,D.H.: The structure of Apo R268A human aldose reductase: Hinges andlatches that control the kinetic mechanism. Biochim. Biophys. Acta(2005) 1748, 201-212. {Pubmed:15769597}; PENTACON Notes: Mutant: S210A AAP, DGA, ASD 12/7/2011 1111 2200001574 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.13 {DL-glyceraldehyde} (#4# pH 7.0, 25°C, recombinant mutantS214A <59>) <59> 0.13 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# pH 7.0, 25°C, recombinant mutantS214A <59> Y Y ECO:0000006 Pubmed:15769597 BRENDA <59> Bohren, K.M.; Brownlee, J.M.; Milne, A.C.; Gabbay, K.H.; Harrison,D.H.: The structure of Apo R268A human aldose reductase: Hinges andlatches that control the kinetic mechanism. Biochim. Biophys. Acta(2005) 1748, 201-212. {Pubmed:15769597}; PENTACON Notes: Mutant: S214A AAP, DGA, ASD 12/7/2011 1111 2200001575 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.42 {DL-glyceraldehyde} (#4# pH 7.0, 25°C, recombinant mutantG213S <59>) <59> 0.42 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# pH 7.0, 25°C, recombinant mutantG213S <59> Y Y ECO:0000006 Pubmed:15769597 BRENDA <59> Bohren, K.M.; Brownlee, J.M.; Milne, A.C.; Gabbay, K.H.; Harrison,D.H.: The structure of Apo R268A human aldose reductase: Hinges andlatches that control the kinetic mechanism. Biochim. Biophys. Acta(2005) 1748, 201-212. {Pubmed:15769597}; PENTACON Notes: Mutant: G213S AAP, DGA, ASD 12/7/2011 1111 2200001576 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.5 {DL-glyceraldehyde} (#4# pH 7.0, 25°C, recombinant mutantDELTA214-219 <59>) <59> 0.5 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# pH 7.0, 25°C, recombinant mutantDELTA214-219 <59> Y Y ECO:0000006 Pubmed:15769597 BRENDA <59> Bohren, K.M.; Brownlee, J.M.; Milne, A.C.; Gabbay, K.H.; Harrison,D.H.: The structure of Apo R268A human aldose reductase: Hinges andlatches that control the kinetic mechanism. Biochim. Biophys. Acta(2005) 1748, 201-212. {Pubmed:15769597}; PENTACON Notes: Mutant: DELTA214-219 AAP, DGA, ASD 12/7/2011 1111 2200001577 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.6 {DL-glyceraldehyde} (#4# pH 7.0, 25°C, recombinant mutantC298A <59>) <59> 0.6 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# pH 7.0, 25°C, recombinant mutantC298A <59> Y Y ECO:0000006 Pubmed:15769597 BRENDA <59> Bohren, K.M.; Brownlee, J.M.; Milne, A.C.; Gabbay, K.H.; Harrison,D.H.: The structure of Apo R268A human aldose reductase: Hinges andlatches that control the kinetic mechanism. Biochim. Biophys. Acta(2005) 1748, 201-212. {Pubmed:15769597}; PENTACON Notes: Mutant: C298A AAP, DGA, ASD 12/7/2011 1111 2200001578 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 3.7 {DL-glyceraldehyde} (#4# pH 7.0, 25°C, recombinant mutantG213P <59>) <59> 3.7 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# pH 7.0, 25°C, recombinant mutantG213P <59> Y Y ECO:0000006 Pubmed:15769597 BRENDA <59> Bohren, K.M.; Brownlee, J.M.; Milne, A.C.; Gabbay, K.H.; Harrison,D.H.: The structure of Apo R268A human aldose reductase: Hinges andlatches that control the kinetic mechanism. Biochim. Biophys. Acta(2005) 1748, 201-212. {Pubmed:15769597}; PENTACON Notes: Mutant: G213P AAP, DGA, ASD 12/7/2011 1111 2200001579 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.02 {DL-glyceraldehyde} (#4# pH 7.0, 25°C, recombinant mutant R293A <59>; #4# pH7.0, 25°C, recombinant mutant W219A <59>; #4# pH 7.0, 25°C,recombinant mutant W219E <59>) <19,59> 0.02 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# pH 7.0, 25°C, recombinant mutant R293A <59>; #4# pH7.0, 25°C, recombinant mutant W219A <59>; #4# pH 7.0, 25°C,recombinant mutant W219E <59> Y Y ECO:0000006 Pubmed:15769597 BRENDA <59> Bohren, K.M.; Brownlee, J.M.; Milne, A.C.; Gabbay, K.H.; Harrison,D.H.: The structure of Apo R268A human aldose reductase: Hinges andlatches that control the kinetic mechanism. Biochim. Biophys. Acta(2005) 1748, 201-212. {Pubmed:15769597}; PENTACON Notes: Mutant: recombinant mutant R293A, recombinant mutant W219A, recombinant mutant W219E AAP, DGA, ASD 12/7/2011 1111 2200001580 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.1 {D-Xylose} mutant R293A 2.1 mM D-xylose CHEBI:65327 Y Y ECO:0000006 Pubmed:15769597 PENTACON Added by PENTACON; PENTACON Notes: Mutant: R293A AAP, DGA, ASD 4/21/2014 3 2200001581 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 5.6 {D-Xylose} mutant W219E 5.6 mM D-xylose CHEBI:65327 Y Y ECO:0000006 Pubmed:15769597 PENTACON Added by PENTACON; PENTACON Notes: Mutant: W219E AAP, DGA, ASD 4/21/2014 3 2200001582 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 6.0 {D-Xylose} wild-type 6.0 mM D-xylose CHEBI:65327 Y Y ECO:0000006 Pubmed:15769597 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001583 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 8.0 {D-Xylose} mutant R268A 8.0 mM D-xylose CHEBI:65327 Y Y ECO:0000006 Pubmed:15769597 PENTACON Added by PENTACON; PENTACON Notes: Mutant: R268A AAP, DGA, ASD 4/21/2014 3 2200001584 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 9.2 {D-Xylose} mutant W219A 9.2 mM D-xylose CHEBI:65327 Y Y ECO:0000006 Pubmed:15769597 PENTACON Added by PENTACON; PENTACON Notes: Mutant: W219A AAP, DGA, ASD 4/21/2014 3 2200001585 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 11 {D-Xylose} mutant S226A 11.0 mM D-xylose CHEBI:65327 Y Y ECO:0000006 Pubmed:15769597 PENTACON Added by PENTACON; PENTACON Notes: Mutant: S226A AAP, DGA, ASD 4/21/2014 3 2200001586 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 48 {D-Xylose} mutant S214A 48.0 mM D-xylose CHEBI:65327 Y Y ECO:0000006 Pubmed:15769597 PENTACON Added by PENTACON; PENTACON Notes: Mutant: S214A AAP, DGA, ASD 4/21/2014 3 2200001587 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 58 {D-Xylose} mutant S210A 58.0 mM D-xylose CHEBI:65327 Y Y ECO:0000006 Pubmed:15769597 PENTACON Added by PENTACON; PENTACON Notes: Mutant: S210A AAP, DGA, ASD 4/21/2014 3 2200001588 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 260 {D-Xylose} mutant G213S 260.0 mM D-xylose CHEBI:65327 Y Y ECO:0000006 Pubmed:15769597 PENTACON Added by PENTACON; PENTACON Notes: Mutant: G213S AAP, DGA, ASD 4/21/2014 3 2200001589 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 270 {D-Xylose} mutant DELTA214-219 270.0 mM D-xylose CHEBI:65327 Y Y ECO:0000006 Pubmed:15769597 PENTACON Added by PENTACON; PENTACON Notes: Mutant: DELTA214-219 AAP, DGA, ASD 4/21/2014 3 2200001590 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 400 {D-Xylose} mutant C298A 400.0 mM D-xylose CHEBI:65327 Y Y ECO:0000006 Pubmed:15769597 PENTACON Added by PENTACON; PENTACON Notes: Mutant: C298A AAP, DGA, ASD 4/21/2014 3 2200001591 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 5000 {D-Xylose} mutant G213P 5000.0 mM D-xylose CHEBI:65327 Y Y ECO:0000006 Pubmed:15769597 PENTACON Added by PENTACON; PENTACON Notes: Mutant: G213P AAP, DGA, ASD 4/21/2014 3 2200001592 Jodi O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.16 {prostaglandin H2} <25> 0.16 mM prostaglandin H2 CHEBI:15554 5.3.99.3 Y Y ECO:0000006 Pubmed:16399384 BRENDA <25> Pettersson, P.L.; Thoren, S.; Jakobsson, P.J.: Human microsomalprostaglandin E synthase 1: a member of the MAPEG protein superfamily.Methods Enzymol. (2005) 401, 147-161. {Pubmed:16399384} AAP, DGA 12/7/2011 1111 2200001593 Jodi O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.16 {prostaglandin G2} <12,25> 0.16 mM prostaglandin G2 CHEBI:27647 5.3.99.3 Y Y ECO:0000006 Pubmed:16399384 BRENDA <25> Pettersson, P.L.; Thoren, S.; Jakobsson, P.J.: Human microsomalprostaglandin E synthase 1: a member of the MAPEG protein superfamily.Methods Enzymol. (2005) 401, 147-161. {Pubmed:16399384} AAP, DGA 12/7/2011 1111 2200001594 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0021 {arachidonic acid} (#3# wild-type, cyclooxygenase activity<51>) <51> 0.0021 mM arachidonic acid CHEBI:15843 1.14.99.1 #3# wild-type, cyclooxygenase activity<51> Y Y ECO:0000006 Pubmed:16401081 BRENDA <51> Rogge, C.E.; Ho, B.; Liu, W.; Kulmacz, R.J.; Tsai, A.L.: Role ofTyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitorinteractions in prostaglandin H synthase-2. Biochemistry (2006) 45,523-532. {Pubmed:16401081} AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001595 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0034 {arachidonic acid} (#3# mutant Y348F/Y504F, cyclooxygenaseactivity <51>) <51> 0.0034 mM arachidonic acid CHEBI:15843 1.14.99.1 #3# mutant Y348F/Y504F, cyclooxygenaseactivity <51> Y Y ECO:0000006 Pubmed:16401081 BRENDA <51> Rogge, C.E.; Ho, B.; Liu, W.; Kulmacz, R.J.; Tsai, A.L.: Role ofTyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitorinteractions in prostaglandin H synthase-2. Biochemistry (2006) 45,523-532. {Pubmed:16401081}; PENTACON Notes: Mutant: mutant Y348F/Y504F AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001596 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0038 {arachidonic acid} (#3# mutant Y348F, cyclooxygenaseactivity <51>) <51> 0.0038 mM arachidonic acid CHEBI:15843 1.14.99.1 #3# mutant Y348F, cyclooxygenaseactivity <51> Y Y ECO:0000006 Pubmed:16401081 BRENDA <51> Rogge, C.E.; Ho, B.; Liu, W.; Kulmacz, R.J.; Tsai, A.L.: Role ofTyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitorinteractions in prostaglandin H synthase-2. Biochemistry (2006) 45,523-532. {Pubmed:16401081}; PENTACON Notes: Mutant: mutant Y348F AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001597 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0042 {arachidonic acid} (#3# mutant Y504F, cyclooxygenaseactivity <51>) <51> 0.0042 mM arachidonic acid CHEBI:15843 1.14.99.1 #3# mutant Y504F, cyclooxygenaseactivity <51> Y Y ECO:0000006 Pubmed:16401081 BRENDA <51> Rogge, C.E.; Ho, B.; Liu, W.; Kulmacz, R.J.; Tsai, A.L.: Role ofTyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitorinteractions in prostaglandin H synthase-2. Biochemistry (2006) 45,523-532. {Pubmed:16401081}; PENTACON Notes: Mutant: mutant Y504F AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001598 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #3# 0.00068 {nimesulide} (#3# wildtype <51>) <51> 0.00068 mM nimesulide CHEBI:44445 arachidonate CHEBI:32395 Y Y ECO:0000006 Pubmed:16401081 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001599 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# .138 {PPHP} (#3# wildtype, peroxidase activity <51>) <51> 0.138 mM PPHP CHEBI:NONE_148513 Y Y ECO:0000006 Pubmed:16401081 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: 5-phenylpent-4-enyl-1-hydroperoxide, Pubchem ID: CID 6438577 AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001600 Jenn O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.13 {prostaglandin H2} (#2#wild-type, 0°C, pH 7.2 <38>) <38> 0.13 mM prostaglandin H2 CHEBI:15554 5.3.99.3 #2#wild-type, 0°C, pH 7.2 <38> Y Y ECO:0000006 Pubmed:16439136 BRENDA <38> Huang, X.; Yan, W.; Gao, D.; Tong, M.; Tai, H.H.; Zhan, C.G.:Structural and functional characterization of human microsomalprostaglandin E synthase-1 by computational modeling and site-directedmutagenesis. Bioorg. Med. Chem. (2006) 14, 3553-3562. {Pubmed:16439136} AAP, DGA 12/7/2011 1111 2200001601 Jenn O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.734 {prostaglandin H2} (#2#mutant Q134E, 0°C, pH 7.2 <38>) <38> 0.734 mM prostaglandin H2 CHEBI:15554 5.3.99.3 #2#mutant Q134E, 0°C, pH 7.2 <38> Y Y ECO:0000006 Pubmed:16439136 BRENDA <38> Huang, X.; Yan, W.; Gao, D.; Tong, M.; Tai, H.H.; Zhan, C.G.:Structural and functional characterization of human microsomalprostaglandin E synthase-1 by computational modeling and site-directedmutagenesis. Bioorg. Med. Chem. (2006) 14, 3553-3562. {Pubmed:16439136}; PENTACON Notes: Mutant: mutant Q134E AAP, DGA 12/7/2011 1111 2200001602 Jenn O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 1.61 {prostaglandin H2} (#2#mutant Q36E, 0°C, pH 7.2 <38>) <38> 1.61 mM prostaglandin H2 CHEBI:15554 5.3.99.3 #2#mutant Q36E, 0°C, pH 7.2 <38> Y Y ECO:0000006 Pubmed:16439136 BRENDA <38> Huang, X.; Yan, W.; Gao, D.; Tong, M.; Tai, H.H.; Zhan, C.G.:Structural and functional characterization of human microsomalprostaglandin E synthase-1 by computational modeling and site-directedmutagenesis. Bioorg. Med. Chem. (2006) 14, 3553-3562. {Pubmed:16439136}; PENTACON Notes: Mutant: mutant Q36E AAP, DGA 12/7/2011 1111 2200001603 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #16# 0.002 {cis-8,11,14-eicosatrienoic acid} <57> 0.002 mM all-cis-icosa-8,11,14-trienoic acid CHEBI:53486 1.14.99.1 Y Y ECO:0000006 Pubmed:16770009 BRENDA <57> Liu, W.; Cao, D.; Oh, S.F.; Serhan, C.N.; Kulmacz, R.J.: Divergentcyclooxygenase responses to fatty acid structure and peroxide level infish and mammalian prostaglandin H synthases. FASEB J. (2006) 20,1097-1108. {Pubmed:16770009} AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001604 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.0017 {cis-5,8,11,14-eicosatetraenoic acid} <57> 0.0017 mM arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16770009 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001605 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.0031 {alpha-linolenic acid} <57> 0.0031 mM alpha-linolenic acid CHEBI:27432 Y Y ECO:0000006 Pubmed:16770009 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001606 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.0011 {cis-4,7,10,13,16,19-docosahexaenoic acid} <57> 0.0011 mM all-cis-docosa-4,7,10,13,16,19-hexaenoic acid CHEBI:28125 Y Y ECO:0000006 Pubmed:16770009 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001607 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.0012 {cis-5,8,11,14,17-eicosapentaenoic acid} <57> 0.0012 mM all-cis-5,8,11,14,17-icosapentaenoic acid CHEBI:28364 Y Y ECO:0000006 Pubmed:16770009 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001608 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.0048 {gamma-linolenic acid} <57> 0.0048 mM gamma-linolenic acid CHEBI:28661 Y Y ECO:0000006 Pubmed:16770009 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001609 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.0027 {cis-7,10,13,16-docosatetraenoic acid} <57> 0.0027 mM all-cis-docosa-7,10,13,16-tetraenoic acid CHEBI:53487 Y Y ECO:0000006 Pubmed:16770009 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001610 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.0052 {cis-11,14-eicosadienoic acid} <57> 0.0052 mM (11Z,14Z)-eicosadienoic acid CHEBI:73731 Y Y ECO:0000006 Pubmed:16770009 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001611 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.309 {prostaglandin E2} (#6# wild-type, 37°C, pH 7.4 <61>) <61> 0.309 mM prostaglandin E2 CHEBI:15551 1.1.1.184 #6# wild-type, 37°C, pH 7.4 <61> Y Y ECO:0000006 Pubmed:17344335 BRENDA <61> Gonzalez-Covarrubias, V.; Ghosh, D.; Lakhman, S.S.; Pendyala, L.;Blanco, J.G.: A functional genetic polymorphism on human carbonylreductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH bindingaffinity. Drug Metab. Dispos. (2007) 35, 973-980. {Pubmed:17344335} AAP, ASD 12/7/2011 1111 2200001612 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.32 {prostaglandin E2} (#6# mutant V88I, 37°C, pH 7.4 <61>) <61> 0.32 mM prostaglandin E2 CHEBI:15551 1.1.1.184 #6# mutant V88I, 37°C, pH 7.4 <61> Y Y ECO:0000006 Pubmed:17344335 BRENDA <61> Gonzalez-Covarrubias, V.; Ghosh, D.; Lakhman, S.S.; Pendyala, L.;Blanco, J.G.: A functional genetic polymorphism on human carbonylreductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH bindingaffinity. Drug Metab. Dispos. (2007) 35, 973-980. {Pubmed:17344335}; PENTACON Notes: Mutant: mutant V88I AAP, ASD 12/7/2011 1111 2200001613 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.247 {NADPH} (#6# wild-type, 37°C, pH 7.4 <61>) <61> 0.247 mM NADPH CHEBI:16474 1.1.1.184 #6# wild-type, 37°C, pH 7.4 <61> Y Y ECO:0000006 Pubmed:17344335 BRENDA <61> Gonzalez-Covarrubias, V.; Ghosh, D.; Lakhman, S.S.; Pendyala, L.;Blanco, J.G.: A functional genetic polymorphism on human carbonylreductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH bindingaffinity. Drug Metab. Dispos. (2007) 35, 973-980. {Pubmed:17344335} AAP, ASD 12/7/2011 1111 2200001614 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.343 {NADPH} (#6# mutant V88I, 37°C, pH 7.4 <61>) <61> 0.343 mM NADPH CHEBI:16474 1.1.1.184 #6# mutant V88I, 37°C, pH 7.4 <61> Y Y ECO:0000006 Pubmed:17344335 BRENDA <61> Gonzalez-Covarrubias, V.; Ghosh, D.; Lakhman, S.S.; Pendyala, L.;Blanco, J.G.: A functional genetic polymorphism on human carbonylreductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH bindingaffinity. Drug Metab. Dispos. (2007) 35, 973-980. {Pubmed:17344335} ; PENTACON Notes: Mutant: mutant V88I AAP, ASD 12/7/2011 1111 2200001615 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.042 {menadione} (#6# wild-type, 37°C, pH 7.4 <61>) <61> 0.042 mM menadione CHEBI:28869 1.1.1.184 #6# wild-type, 37°C, pH 7.4 <61> Y Y ECO:0000006 Pubmed:17344335 BRENDA <61> Gonzalez-Covarrubias, V.; Ghosh, D.; Lakhman, S.S.; Pendyala, L.;Blanco, J.G.: A functional genetic polymorphism on human carbonylreductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH bindingaffinity. Drug Metab. Dispos. (2007) 35, 973-980. {Pubmed:17344335} AAP, ASD 12/7/2011 1111 2200001616 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.055 {menadione} (#6# mutant V88I, 37°C, pH 7.4 <61>) <61> 0.055 mM menadione CHEBI:28869 1.1.1.184 #6# mutant V88I, 37°C, pH 7.4 <61> Y Y ECO:0000006 Pubmed:17344335 BRENDA <61> Gonzalez-Covarrubias, V.; Ghosh, D.; Lakhman, S.S.; Pendyala, L.;Blanco, J.G.: A functional genetic polymorphism on human carbonylreductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH bindingaffinity. Drug Metab. Dispos. (2007) 35, 973-980. {Pubmed:17344335}; PENTACON Notes: Mutant: mutant V88I AAP, ASD 12/7/2011 1111 2200001617 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.14 {daunorubicin} (#6# mutant V88I, 37°C, pH 7.4 <61>) <61> 0.14 mM daunorubicin CHEBI:41977 1.1.1.184 #6# mutant V88I, 37°C, pH 7.4 <61> Y Y ECO:0000006 Pubmed:17344335 BRENDA <61> Gonzalez-Covarrubias, V.; Ghosh, D.; Lakhman, S.S.; Pendyala, L.;Blanco, J.G.: A functional genetic polymorphism on human carbonylreductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH bindingaffinity. Drug Metab. Dispos. (2007) 35, 973-980. {Pubmed:17344335}; PENTACON Notes: Mutant: mutant V88I AAP, ASD 12/7/2011 1111 2200001618 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.173 {daunorubicin} (#6# wild-type, 37°C, pH 7.4 <61>) <61> 0.173 mM daunorubicin CHEBI:41977 1.1.1.184 #6# wild-type, 37°C, pH 7.4 <61> Y Y ECO:0000006 Pubmed:17344335 BRENDA <61> Gonzalez-Covarrubias, V.; Ghosh, D.; Lakhman, S.S.; Pendyala, L.;Blanco, J.G.: A functional genetic polymorphism on human carbonylreductase 1 (CBR1 V88I) impacts on catalytic activity and NADPH bindingaffinity. Drug Metab. Dispos. (2007) 35, 973-980. {Pubmed:17344335} AAP, ASD 12/7/2011 1111 2200001619 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 35 {prostaglandin E2} (#6# mutant V88I, 37°C, pH 7.4 <61>) <61> 35.0 nmol/min/mg prostaglandin E2 CHEBI:15551 Y Y ECO:0000006 Pubmed:17344335 PENTACON Added by PENTACON; PENTACON Notes: Mutant: mutant V88I; pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001620 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 53 {prostaglandin E2} (#6# wild-type, 37°C, pH 7.4 <61>) <61> 53.0 nmol/min/mg prostaglandin E2 CHEBI:15551 Y Y ECO:0000006 Pubmed:17344335 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001621 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 295 {NADPH} (#6# mutant V88I, 37°C, pH 7.4 <61>) <61> 295.0 nmol/min/mg NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:17344335 PENTACON Added by PENTACON; PENTACON Notes: Mutant: mutant V88I; pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001622 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 356 {NADPH} (#6# wild-type, 37°C, pH 7.4 <61>) <61> 356.0 nmol/min/mg NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:17344335 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001623 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 168 {menadione} (#6# mutant V88I, 37°C, pH 7.4 <61>) <61> 168.0 nmol/min/mg menadione CHEBI:28869 Y Y ECO:0000006 Pubmed:17344335 PENTACON Added by PENTACON; PENTACON Notes: Mutant: mutant V88I; pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001624 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 220 {menadione} (#6# wild-type, 37°C, pH 7.4 <61>) <61> 220.0 nmol/min/mg menadione CHEBI:28869 Y Y ECO:0000006 Pubmed:17344335 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001625 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 121 {daunorubicin} (#6# mutant V88I, 37°C, pH 7.4 <61>) <61> 121.0 nmol/min/mg daunorubicin CHEBI:41977 Y Y ECO:0000006 Pubmed:17344335 PENTACON Added by PENTACON; PENTACON Notes: Mutant: mutant V88I; pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001626 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 181 {daunorubicin} (#6# wild-type, 37°C, pH 7.4 <61>) <61> 181.0 nmol/min/mg daunorubicin CHEBI:41977 Y Y ECO:0000006 Pubmed:17344335 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 37°C AAP, ASD 4/21/2014 3 2200001627 Jenn P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0066 {DELTA4-andostene-3,17-dione} (#2# pH 7.0, 37°C <39>) <39> 0.0066 mM androst-4-ene-3,17-dione CHEBI:16422 1.1.1.188 #2# pH 7.0, 37°C <39> Y Y ECO:0000006 Pubmed:17950253 BRENDA <39> Byrns, M.C.; Steckelbroeck, S.; Penning, T.M.: An indomethacinanalogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor ofaldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, andprostaglandin F synthase), a potential target for the treatment ofhormone dependent and hormone independent malignancies. Biochem.Pharmacol. (2008) 75, 484-493. {Pubmed:17950253} AAP, ASD 12/7/2011 1111 2200001628 Jenn P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0015 {9,10-Phenanthrenequinone} (#2# pH 7.0, 37°C <39>) <39> 0.0015 mM 9,10-phenanthroquinone CHEBI:37454 1.1.1.188 #2# pH 7.0, 37°C <39> Y Y ECO:0000006 Pubmed:17950253 BRENDA <39> Byrns, M.C.; Steckelbroeck, S.; Penning, T.M.: An indomethacinanalogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor ofaldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, andprostaglandin F synthase), a potential target for the treatment ofhormone dependent and hormone independent malignancies. Biochem.Pharmacol. (2008) 75, 484-493. {Pubmed:17950253} AAP, ASD 12/7/2011 1111 2200001629 Jenn P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #2# 0.04 {Zomepirac} (#2# pH 7.0, 37°C <39>) <39> 0.04 mM zomepirac CHEBI:35859 9,10-phenanthroquinone CHEBI:37454 Y Y ECO:0000006 Pubmed:17950253 PENTACON Added by PENTACON; PENTACON Notes: pH 7.0, 37°C AAP, ASD 4/21/2014 3 2200001630 Jenn P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #2# 0.0023 {indomethacin} (#2# pH 7.0, 37°C <39>) <39> 0.0023 mM indometacin CHEBI:49662 9,10-phenanthroquinone CHEBI:37454 Y Y ECO:0000006 Pubmed:17950253 PENTACON Added by PENTACON; PENTACON Notes: pH 7.0, 37°C AAP, ASD 4/21/2014 3 2200001631 Jenn P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #2# 0.0078 {Flurbiprofen} (#2# pH 7.0, 37°C <39>) <39> 0.0078 mM flurbiprofen CHEBI:5130 9,10-phenanthroquinone CHEBI:37454 Y Y ECO:0000006 Pubmed:17950253 PENTACON Added by PENTACON; PENTACON Notes: pH 7.0, 37°C AAP, ASD 4/21/2014 3 2200001632 Jenn P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #2# 0.0099 {Ibuprofen} (#2# pH 7.0, 37°C <39>) <39> 0.0099 mM ibuprofen CHEBI:5855 9,10-phenanthroquinone CHEBI:37454 Y Y ECO:0000006 Pubmed:17950253 PENTACON Added by PENTACON; PENTACON Notes: pH 7.0, 37°C AAP, ASD 4/21/2014 3 2200001633 Jenn P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #2# 0.007 {Meclofenamic Acid} (#2# pH 7.0, 37°C <39>) <39> 0.007 mM meclofenamic acid CHEBI:6710 9,10-phenanthroquinone CHEBI:37454 Y Y ECO:0000006 Pubmed:17950253 PENTACON Added by PENTACON; PENTACON Notes: pH 7.0, 37°C AAP, ASD 4/21/2014 3 2200001634 Jenn P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #2# 0.0014 {Naproxen} (#2# pH 7.0, 37°C <39>) <39> 0.0014 mM naproxen CHEBI:7476 9,10-phenanthroquinone CHEBI:37454 Y Y ECO:0000006 Pubmed:17950253 PENTACON Added by PENTACON; PENTACON Notes: pH 7.0, 37°C AAP, ASD 4/21/2014 3 2200001635 Jenn P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #2# 0.0034 {sulindac} (#2# pH 7.0, 37°C <39>) <39> 0.0034 mM sulindac CHEBI:9352 9,10-phenanthroquinone CHEBI:37454 Y Y ECO:0000006 Pubmed:17950253 PENTACON Added by PENTACON; PENTACON Notes: pH 7.0, 37°C AAP, ASD 4/21/2014 3 2200001636 Jenn P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #2# 0.052 {N-(4-aminobenzyl)-6-methoxy-3-indole acetic acid} (#2# pH 7.0, 37°C <39>) <39> 0.052 mM N-(4-aminobenzyl)-6-methoxy-3-indole acetic acid CHEBI:NONE_148514 9,10-phenanthroquinone CHEBI:37454 Y Y ECO:0000006 Pubmed:17950253 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: N-(4-aminobenzyl)-6-methoxy-3-indole acetic acid; PENTACON Notes: Added by PENTACON; PENTACON Notes: pH 7.0, 37°C AAP, ASD 4/21/2014 3 2200001637 Jodi O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 0.13 {4-Nitrobenzaldehyde} (#27# pH 6.5, 25°C <65>) <65> 0.13 mM 4-nitrobenzaldehyde CHEBI:66926 1.1.1.184 #27# pH 6.5, 25°C <65> Y Y ECO:0000006 Pubmed:18493841 BRENDA <65> Miura, T.; Nishinaka, T.; Terada, T.: Different functions betweenhuman monomeric carbonyl reductase 3 and carbonyl reductase 1. Mol.Cell. Biochem. (2008) 315, 113-121. {Pubmed:18493841} AAP, ASD 12/7/2011 1111 2200001638 Jodi O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 0.3 {4-benzoylpyridine} (#27# pH 6.5, 25°C <65>) <65> 0.3 mM 4-benzoylpyridine CHEBI:NONE_148506 1.1.1.184 #27# pH 6.5, 25°C <65> Y Y ECO:0000006 Pubmed:18493841 BRENDA <65> Miura, T.; Nishinaka, T.; Terada, T.: Different functions betweenhuman monomeric carbonyl reductase 3 and carbonyl reductase 1. Mol.Cell. Biochem. (2008) 315, 113-121. {Pubmed:18493841}; PENTACON Notes: Request ChEBI ID: 4-benzoylpyridine, PubChem ID: CID 26731 AAP, ASD 12/7/2011 1111 2200001639 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.0852 {daunorubicin} (#6# pH 7.4, 37°C <60>) <60> 0.0852 mM daunorubicin CHEBI:41977 1.1.1.184 #6# pH 7.4, 37°C <60> Y Y ECO:0000006 Pubmed:18579125 BRENDA <60> Carlquist, M.; Frejd, T.; Gorwa-Grauslund, M.F.: Flavonoids asinhibitors of human carbonyl reductase 1. Chem. Biol. Interact. (2008)174, 98-108. {Pubmed:18579125} AAP, ASD 12/7/2011 1111 2200001640 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 3.490 {daunorubicin} 3490.0 nmol/min/mg daunorubicin CHEBI:41977 Y Y ECO:0000006 Pubmed:18579125 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001641 Jenn P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #25# 0.129 {Doxorubicin} (#25# purified enzyme <76>) <76> 0.129 mM doxorubicin CHEBI:28748 Y Y ECO:0000006 Pubmed:18635746 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001642 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #25# 20.6 {Doxorubicin} (#25# purified enzyme <76>) <76> 20.6 nmol/min/mg doxorubicin CHEBI:28748 Y Y ECO:0000006 Pubmed:18635746 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001643 Jenn P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #25# 183.5 {Doxorubicin} (#25# purified enzyme <76>) <76> 183.5 nmol/min/mg doxorubicin CHEBI:28748 Y Y ECO:0000006 Pubmed:18635746 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001644 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #25# 0.167 {Doxorubicin} (#25# purified enzyme <76>) <76> 0.167 mM doxorubicin CHEBI:28748 1.1.1.184 #25# purified enzyme <76> Y Y ECO:0000006 Pubmed:18635746 BRENDA <76> Kassner, N.; Huse, K.; Martin, H.J.; Goedtel-Armbrust, U.;Metzger, A.; Meineke, I.; Brockmoeller, J.; Klein, K.; Zanger, U.M.;Maser, E.; Wojnowski, L.: Carbonyl reductase 1 is a predominantdoxorubicin reductase in the human liver. Drug Metab. Dispos. (2008)36, 2113-2120. {Pubmed:18635746} AAP, ASD 12/7/2011 1111 2200001645 Jodi P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #11# 0.0019 {prostaglandin H2} <47> 0.0019 mM prostaglandin H2 CHEBI:15554 1.1.1.188 Y Y ECO:0000006 Pubmed:19010934 BRENDA <47> Kabututu, Z.; Manin, M.; Pointud, J.C.; Maruyama, T.; Nagata, N.;Lambert, S.; Lefrancois-Martinez, A.M.; Martinez, A.; Urade, Y.:Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1,1B3 and 1B7. J. Biochem. (2009) 145, 161-168. {Pubmed:19010934} AAP, DGA, ASD 12/7/2011 1111 2200001646 Jodi P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #15# 0.018 {prostaglandin H2} <47> 0.018 mM prostaglandin H2 CHEBI:15554 1.1.1.188 Y Y ECO:0000006 Pubmed:19010934 BRENDA <47> Kabututu, Z.; Manin, M.; Pointud, J.C.; Maruyama, T.; Nagata, N.;Lambert, S.; Lefrancois-Martinez, A.M.; Martinez, A.; Urade, Y.:Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1,1B3 and 1B7. J. Biochem. (2009) 145, 161-168. {Pubmed:19010934} AAP, ASD 12/7/2011 1111 2200001647 Jodi P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #11# 0.0057 {NADPH} <47> 0.0057 mM NADPH CHEBI:16474 1.1.1.188 Y Y ECO:0000006 Pubmed:19010934 BRENDA <47> Kabututu, Z.; Manin, M.; Pointud, J.C.; Maruyama, T.; Nagata, N.;Lambert, S.; Lefrancois-Martinez, A.M.; Martinez, A.; Urade, Y.:Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1,1B3 and 1B7. J. Biochem. (2009) 145, 161-168. {Pubmed:19010934} AAP, DGA, ASD 12/7/2011 1111 2200001648 Jodi P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #15# 3.9 {prostaglandin H2} <47> 3.9 nmol/min/mg prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 Pubmed:19010934 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001649 Jodi P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #15# 26 {prostaglandin H2} <47> 26.0 nmol/min/mg prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 Pubmed:19010934 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001650 Jodi P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #11# 0.009 {4-nitrobenzaldehyde} <47> 0.009 mM 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:19010934 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001651 Jodi P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #11# 37.1 {4-nitrobenzaldehyde} <47> 37.1 nmol/min/mg 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:19010934 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001652 Jodi P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #11# 0.012 {4-nitrobenzaldehyde} <47> 0.012 mM 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:19010934 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001653 Jodi P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #11# 408.3 {4-nitrobenzaldehyde} <47> 408.3 nmol/min/mg 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:19010934 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001654 Jenn O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0024 {(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate} <55> 0.0024 mM prostaglandin H2 CHEBI:15554 5.3.99.3 Y Y ECO:0000006 Pubmed:19017494 BRENDA <55> Kim, W.I.; Choi, K.A.; Do, H.S.; Yu, Y.G.: Expression andpurification of human mPGES-1 in E. coli and identification ofinhibitory compounds from a drug-library. BMB Rep. (2008) 41, 808-813.{Pubmed:19017494} AAP, DGA 12/7/2011 1111 2200001655 Jenn O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #2# 0.0024 {(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate} <55> 0.23 mM dyphylline CHEBI:4728 prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 Pubmed:19017494 PENTACON Added by PENTACON AAP, DGA 4/21/2014 3 2200001656 Jenn O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #2# 0.0024 {(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate} <55> 0.11 mM oxacillin CHEBI:7809 prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 Pubmed:19017494 PENTACON Added by PENTACON AAP, DGA 4/21/2014 3 2200001657 Jenn O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #2# 0.0024 {(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate} <55> 3.5 nmol/min/mg prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 Pubmed:19017494 PENTACON Added by PENTACON AAP, DGA 4/21/2014 3 2200001658 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 49.3 {D-galactose} <2> 49.3 mM D-galactose CHEBI:12936 1.1.1.21 Y Y ECO:0000006 Pubmed:1901806 BRENDA <2> Tanimoto, T.; Ohta, M.; Tanaka, A.; Ikemoto, I.; Machida, T.:Purification and characterization of human testis aldose and aldehydereductase. Int. J. Biochem. (1991) 23, 421-428. {Pubmed:1901806} AAP, DGA, ASD 12/7/2011 1111 2200001659 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 5.05 {D-glucuronate} <2> 5.05 mM D-glucuronate CHEBI:15748 1.1.1.21 Y Y ECO:0000006 Pubmed:1901806 BRENDA <2> Tanimoto, T.; Ohta, M.; Tanaka, A.; Ikemoto, I.; Machida, T.:Purification and characterization of human testis aldose and aldehydereductase. Int. J. Biochem. (1991) 23, 421-428. {Pubmed:1901806} AAP, DGA, ASD 12/7/2011 1111 2200001660 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0032 {NADPH} <2> 0.0032 mM NADPH CHEBI:16474 1.1.1.21 Y Y ECO:0000006 Pubmed:1901806 BRENDA <2> Tanimoto, T.; Ohta, M.; Tanaka, A.; Ikemoto, I.; Machida, T.:Purification and characterization of human testis aldose and aldehydereductase. Int. J. Biochem. (1991) 23, 421-428. {Pubmed:1901806} AAP, DGA, ASD 12/7/2011 1111 2200001661 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.25 {NADH} <2> 0.25 mM NADH CHEBI:16908 1.1.1.21 Y Y ECO:0000006 Pubmed:1901806 BRENDA <2> Tanimoto, T.; Ohta, M.; Tanaka, A.; Ikemoto, I.; Machida, T.:Purification and characterization of human testis aldose and aldehydereductase. Int. J. Biochem. (1991) 23, 421-428. {Pubmed:1901806} AAP, DGA, ASD 12/7/2011 1111 2200001662 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 57.3 {D-glucose} <2> 57.3 mM D-glucose CHEBI:17634 1.1.1.21 Y Y ECO:0000006 Pubmed:1901806 BRENDA <2> Tanimoto, T.; Ohta, M.; Tanaka, A.; Ikemoto, I.; Machida, T.:Purification and characterization of human testis aldose and aldehydereductase. Int. J. Biochem. (1991) 23, 421-428. {Pubmed:1901806} AAP, DGA, ASD 12/7/2011 1111 2200001663 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.026 {DL-glyceraldehyde} <2,6> 0.026 mM glyceraldehyde CHEBI:5445 1.1.1.21 Y Y ECO:0000006 Pubmed:1901806 BRENDA <2> Tanimoto, T.; Ohta, M.; Tanaka, A.; Ikemoto, I.; Machida, T.:Purification and characterization of human testis aldose and aldehydereductase. Int. J. Biochem. (1991) 23, 421-428. {Pubmed:1901806} AAP, DGA, ASD 12/7/2011 1111 2200001664 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 6.2 {D-xylose} <2> 6.2 mM D-xylose CHEBI:65327 1.1.1.21 Y Y ECO:0000006 Pubmed:1901806 BRENDA <2> Tanimoto, T.; Ohta, M.; Tanaka, A.; Ikemoto, I.; Machida, T.:Purification and characterization of human testis aldose and aldehydereductase. Int. J. Biochem. (1991) 23, 421-428. {Pubmed:1901806} AAP, DGA, ASD 12/7/2011 1111 2200001665 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 43.3 {D-galactose} (#4# recombinant from baculovirus system inSpodoptera frugiperda cells <26>) <26> 43.3 mM D-galactose CHEBI:12936 1.1.1.21 #4# recombinant from baculovirus system inSpodoptera frugiperda cells <26> Y Y ECO:0000006 Pubmed:1905957 BRENDA <26> Nishimura, C.; Yamaoka, T.; Mizutani, M.; Yamashita, K.; Akera,T.; Tanimoto, T.: Purification and characterization of the recombinanthuman aldose reductase expressed in baculovirus system. Biochim.Biophys. Acta (1991) 1078, 171-178. {Pubmed:1905957} AAP, DGA, ASD 12/7/2011 1111 2200001666 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 3.53 {D-glucuronate} (#4# recombinant from baculovirus system inSpodoptera frugiperda cells <26>) <26> 3.53 mM D-glucuronate CHEBI:15748 1.1.1.21 #4# recombinant from baculovirus system inSpodoptera frugiperda cells <26> Y Y ECO:0000006 Pubmed:1905957 BRENDA <26> Nishimura, C.; Yamaoka, T.; Mizutani, M.; Yamashita, K.; Akera,T.; Tanimoto, T.: Purification and characterization of the recombinanthuman aldose reductase expressed in baculovirus system. Biochim.Biophys. Acta (1991) 1078, 171-178. {Pubmed:1905957} AAP, DGA, ASD 12/7/2011 1111 2200001667 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.004 {NADPH} (#4# recombinant from baculovirus system inSpodoptera frugiperda cells <26>) <26> 0.004 mM NADPH CHEBI:16474 1.1.1.21 #4# recombinant from baculovirus system inSpodoptera frugiperda cells <26> Y Y ECO:0000006 Pubmed:1905957 BRENDA <26> Nishimura, C.; Yamaoka, T.; Mizutani, M.; Yamashita, K.; Akera,T.; Tanimoto, T.: Purification and characterization of the recombinanthuman aldose reductase expressed in baculovirus system. Biochim.Biophys. Acta (1991) 1078, 171-178. {Pubmed:1905957} AAP, DGA, ASD 12/7/2011 1111 2200001668 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 98.1 {D-glucose} (#4# recombinant from E. coli <25>; #4#recombinant from baculovirus system in Spodoptera frugiperda cells<26>) <25,26> 98.1 mM D-glucose CHEBI:17634 1.1.1.21 #4# recombinant from E. coli <25>; #4#recombinant from baculovirus system in Spodoptera frugiperda cells<26> Y Y ECO:0000006 Pubmed:1905957 BRENDA <26> Nishimura, C.; Yamaoka, T.; Mizutani, M.; Yamashita, K.; Akera,T.; Tanimoto, T.: Purification and characterization of the recombinanthuman aldose reductase expressed in baculovirus system. Biochim.Biophys. Acta (1991) 1078, 171-178. {Pubmed:1905957} AAP, DGA, ASD 12/7/2011 1111 2200001669 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.018 {Glyceraldehyde} (#4# recombinant from baculovirus systemwith Spodoptera frugiperda cells <26>) <6,26> 0.018 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# recombinant from baculovirus systemwith Spodoptera frugiperda cells <26> Y Y ECO:0000006 Pubmed:1905957 BRENDA <26> Nishimura, C.; Yamaoka, T.; Mizutani, M.; Yamashita, K.; Akera,T.; Tanimoto, T.: Purification and characterization of the recombinanthuman aldose reductase expressed in baculovirus system. Biochim.Biophys. Acta (1991) 1078, 171-178. {Pubmed:1905957} AAP, DGA, ASD 12/7/2011 1111 2200001670 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 5.04 {D-xylose} (#4# recombinant fron baculovirus system inSpodoptera frugiperda cells <26>) <26> 5.04 mM D-xylose CHEBI:65327 1.1.1.21 #4# recombinant fron baculovirus system inSpodoptera frugiperda cells <26> Y Y ECO:0000006 Pubmed:1905957 BRENDA <26> Nishimura, C.; Yamaoka, T.; Mizutani, M.; Yamashita, K.; Akera,T.; Tanimoto, T.: Purification and characterization of the recombinanthuman aldose reductase expressed in baculovirus system. Biochim.Biophys. Acta (1991) 1078, 171-178. {Pubmed:1905957} AAP, DGA, ASD 12/7/2011 1111 2200001671 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #4# 0.00032 {sorbinil} (#4# recombinant from baculovirus system inSpodoptera frugiperda cells <26>) <26> 0.00032 mM sorbinil CHEBI:102029 NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:1905957 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001672 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #4# 0.00055 {sorbinil} (#4# purified from human testis <26>) <26> 0.00055 mM sorbinil CHEBI:102029 NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:1905957 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001673 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #4# 0.000018 {tolrestat} (#4# recombinant from baculovirus system inSpodoptera frugiperda cells <26>) <26> 1.8e-05 mM tolrestat CHEBI:48549 NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:1905957 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001674 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #4# 0.000018 {tolrestat} (#4# purified from human testis <26>) <26> 2e-05 mM tolrestat CHEBI:48549 NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:1905957 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001675 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #4# 0.00026 {epalrestat} (#4# purified from human testis <26>) <26> 2.1e-05 mM epalrestat CHEBI:31539 NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:1905957 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: epalrestat, Chembl ID: CHEMBL56337 AAP, DGA, ASD 4/21/2014 3 2200001676 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #4# 0.00026 {epalrestat} (#4# recombinant from baculovirus system inSpodoptera frugiperda cells <26>) <26> 0.00026 mM epalrestat CHEBI:31539 NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:1905957 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: epalrestat, Chembl ID: CHEMBL56337 AAP, DGA, ASD 4/21/2014 3 2200001677 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #4# 0.000014 {imirestat} (#4# recombinant from baculovirus system inSpodoptera frugiperda cells <26>) <26> 1.4e-05 mM imirestat CHEBI:NONE_148515 NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:1905957 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: imirestat, Pubchem ID: CID 65673 AAP, DGA, ASD 4/21/2014 3 2200001678 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #4# 0.000014 {imirestat} (#4# purified from human testis <26>) <26> 1.5e-05 mM imirestat CHEBI:NONE_148515 NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:1905957 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: imirestat, Pubchem ID: CID 65673 AAP, DGA, ASD 4/21/2014 3 2200001679 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #4# 0.0002 {M79175} (#4# recombinant from baculovirus system inSpodoptera frugiperda cells <26>) <26> 0.0002 mM M 79175 CHEBI:NONE_148516 NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:1905957 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: M 79175, Pubchem ID: CID 115090 AAP, DGA, ASD 4/21/2014 3 2200001680 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #4# 0.0002 {M79175} (#4# purified from human testis <26>) <26> 0.00044 mM M 79175 CHEBI:NONE_148516 NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:1905957 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: M 79175, Pubchem ID: CID 115090 AAP, DGA, ASD 4/21/2014 3 2200001681 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #4# 0.000011 {statil} (#4# purified from human testis <26>) <26> 7e-06 mM statil CHEBI:NONE_148517 NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:1905957 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: statil Chembl ID: CHEMBL7679 AAP, DGA, ASD 4/21/2014 3 2200001682 Jenn P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #4# 0.000011 {statil} (#4# recombinant from baculovirus system inSpodoptera frugiperda cells <26>) <26> 0.00032 mM statil CHEBI:NONE_148517 NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:1905957 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: statil, Chembl ID: CHEMBL7679 AAP, DGA, ASD 4/21/2014 3 2200001683 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #25# 0.0078 {isatin} (#25# wild-type CBR1 <75>) <75> 0.0078 mM isatin CHEBI:27539 1.1.1.184 #25# wild-type CBR1 <75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875} AAP, ASD 12/7/2011 1111 2200001684 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 0.0225 {isatin} (#27# residues 142-143, 230, 236-244, 270 of CBR3exchanged to the corresponding amino acids of CBR1 <75>) <75> 0.0225 mM isatin CHEBI:27539 1.1.1.184 #27# residues 142-143, 230, 236-244, 270 of CBR3exchanged to the corresponding amino acids of CBR1 <75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875} ; PENTACON Notes: Mutant: residues 142-143, 230, 236-244, 270 of CBR3 exchanged to the corresponding amino acids of CBR1 AAP, ASD 12/7/2011 1111 2200001685 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 0.0315 {isatin} (#27# residues 142-143, 230, 236-244 of CBR3exchanged to the corresponding amino acids of CBR1 <75>) <75> 0.0315 mM isatin CHEBI:27539 1.1.1.184 #27# residues 142-143, 230, 236-244 of CBR3exchanged to the corresponding amino acids of CBR1 <75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875} ; PENTACON Notes: Mutant: residues 142-143, 230, 236-244 of CBR3 exchanged to the corresponding amino acids of CBR1 AAP, ASD 12/7/2011 1111 2200001686 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 0.0327 {isatin} (#27# residues 230, 236-244, 270 of CBR3exchanged to the corresponding amino acids of CBR1 <75>) <75> 0.0327 mM isatin CHEBI:27539 1.1.1.184 #27# residues 230, 236-244, 270 of CBR3exchanged to the corresponding amino acids of CBR1 <75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875} ; PENTACON Notes: Mutant: residues 230, 236-244, 270 of CBR3 exchanged to the corresponding amino acids of CBR1 AAP, ASD 12/7/2011 1111 2200001687 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 0.0471 {isatin} (#27# residues 230, 236-244 of CBR3 exchanged tothe corresponding amino acids of CBR1 <75>) <75> 0.0471 mM isatin CHEBI:27539 1.1.1.184 #27# residues 230, 236-244 of CBR3 exchanged tothe corresponding amino acids of CBR1 <75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875} ; PENTACON Notes: Mutant: residues 230, 236-244 of CBR3 exchanged to the corresponding amino acids of CBR1 AAP, ASD 12/7/2011 1111 2200001688 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 0.055 {isatin} (#27# residues 97-98, 230, 236-244 of CBR3exchanged to the corresponding amino acids of CBR1 <75>) <75> 0.055 mM isatin CHEBI:27539 1.1.1.184 #27# residues 97-98, 230, 236-244 of CBR3exchanged to the corresponding amino acids of CBR1 <75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875} ; PENTACON Notes: Mutant: residues 97-98, 230, 236-244 of CBR3 exchanged to the corresponding amino acids of CBR1 AAP, ASD 12/7/2011 1111 2200001689 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 1.6 {isatin} (#27# residues 236-244 of CBR3 exchanged to thecorresponding amino acids of CBR1 <75>) <75> 1.6 mM isatin CHEBI:27539 1.1.1.184 #27# residues 236-244 of CBR3 exchanged to thecorresponding amino acids of CBR1 <75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875} ; PENTACON Notes: Mutant: residues 236-244 of CBR3 exchanged to the corresponding amino acids of CBR1 AAP, ASD 12/7/2011 1111 2200001690 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 4 {isatin} (#27# wild-type CBR3 and mutant V244M. Residues262-277, 236-244/262-277 or 230 of CBR3 exchanged to the correspondingamino acids of CBR1 <75>) <75> mM isatin CHEBI:27539 1.1.1.184 #27# wild-type CBR3 and mutant V244M. Residues262-277, 236-244/262-277 or 230 of CBR3 exchanged to the correspondingamino acids of CBR1 <75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875} AAP, ASD 12/7/2011 1111 2200001691 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 4 {isatin} (#27# wild-type CBR3 and mutant V244M. Residues262-277, 236-244/262-277 or 230 of CBR3 exchanged to the correspondingamino acids of CBR1 <75>) <75> mM isatin CHEBI:27539 1.1.1.184 #27# wild-type CBR3 and mutant V244M. Residues262-277, 236-244/262-277 or 230 of CBR3 exchanged to the correspondingamino acids of CBR1 <75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875}; PENTACON Notes: Mutant: mutant V244M. Residues 262-277, 236-244/262-277 or 230 of CBR3 exchanged to the corresponding amino acids of CBR1 AAP, ASD 12/7/2011 1111 2200001692 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 0.0043 {9,10-Phenanthrenequinone} (#27# residues 142-143, 230,236-244, 270 of CBR3 exchanged to the corresponding amino acids of CBR1<75>) <75> 0.0043 mM 9,10-phenanthroquinone CHEBI:37454 1.1.1.184 #27# residues 142-143, 230,236-244, 270 of CBR3 exchanged to the corresponding amino acids of CBR1<75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875}; PENTACON Notes: Mutant: residues 142-143, 230,236-244, 270 of CBR3 exchanged to the corresponding amino acids of CBR1 AAP, ASD 12/7/2011 1111 2200001693 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 0.0089 {9,10-Phenanthrenequinone} (#27# residues 230, 236-244,270 of CBR3 exchanged to the corresponding amino acids of CBR1 <75>) <75> 0.0089 mM 9,10-phenanthroquinone CHEBI:37454 1.1.1.184 #27# residues 230, 236-244,270 of CBR3 exchanged to the corresponding amino acids of CBR1 <75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875}; PENTACON Notes: Mutant: residues 230, 236-244,270 of CBR3 exchanged to the corresponding amino acids of CBR1 AAP, ASD 12/7/2011 1111 2200001694 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 0.0092 {9,10-Phenanthrenequinone} (#27# residues 97-98, 230,236-244 of CBR3 exchanged to the corresponding amino acids of CBR1<75>) <75> 0.0092 mM 9,10-phenanthroquinone CHEBI:37454 1.1.1.184 #27# residues 97-98, 230,236-244 of CBR3 exchanged to the corresponding amino acids of CBR1<75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875}; PENTACON Notes: Mutant: residues 97-98, 230, 236-244 of CBR3 exchanged to the corresponding amino acids of CBR1 AAP, ASD 12/7/2011 1111 2200001695 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #25# 0.0354 {9,10-Phenanthrenequinone} (#25# wild-type CBR1 <75>) <75> 0.0354 mM 9,10-phenanthroquinone CHEBI:37454 1.1.1.184 #25# wild-type CBR1 <75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875} AAP, ASD 12/7/2011 1111 2200001696 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 0.0393 {9,10-Phenanthrenequinone} (#27# residues 142-143, 230,236-244 of CBR3 exchanged to the corresponding amino acids of CBR1<75>) <75> 0.0393 mM 9,10-phenanthroquinone CHEBI:37454 1.1.1.184 #27# residues 142-143, 230,236-244 of CBR3 exchanged to the corresponding amino acids of CBR1<75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875}; PENTACON Notes: Mutant: residues 142-143, 230, 236-244 of CBR3 exchanged to the corresponding amino acids of CBR1 AAP, ASD 12/7/2011 1111 2200001697 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 0.0564 {9,10-Phenanthrenequinone} (#27# residues 230, 236-“244 of CBR3 exchanged to the corresponding amino acids of CBR1 <75>) <75> 0.0564 mM 9,10-phenanthroquinone CHEBI:37454 1.1.1.184 #27# residues 230, 236–244of CBR3 exchanged to the corresponding amino acids of CBR1 <75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875}; PENTACON Notes: Mutant: residues 230, 236-€“244 of CBR3 exchanged to the corresponding amino acids of CBR1 AAP, ASD 12/7/2011 1111 2200001698 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 0.078 {9,10-Phenanthrenequinone} (#27# wild-type CBR3 and mutantV244M. Residues 236-244, 262-277, 236-244/262-277 or 230 of CBR3exchanged to the corresponding amino acids of CBR1 <75>) <75> mM 9,10-phenanthroquinone CHEBI:37454 1.1.1.184 #27# wild-type CBR3 and mutantV244M. Residues 236-244, 262-277, 236-244/262-277 or 230 of CBR3exchanged to the corresponding amino acids of CBR1 <75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875} AAP, ASD 12/7/2011 1111 2200001699 Jenn O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #27# 0.078 {9,10-Phenanthrenequinone} (#27# wild-type CBR3 and mutantV244M. Residues 236-244, 262-277, 236-244/262-277 or 230 of CBR3exchanged to the corresponding amino acids of CBR1 <75>) <75> mM 9,10-phenanthroquinone CHEBI:37454 1.1.1.184 #27# wild-type CBR3 and mutantV244M. Residues 236-244, 262-277, 236-244/262-277 or 230 of CBR3exchanged to the corresponding amino acids of CBR1 <75> Y Y ECO:0000006 Pubmed:19061875 BRENDA <75> El-Hawari, Y.; Favia, A.D.; Pilka, E.S.; Kisiela, M.; Oppermann,U.; Martin, H.J.; Maser, E.: Analysis of the substrate-binding site ofhuman carbonyl reductases CBR1 and CBR3 by site-directed mutagenesis.Chem. Biol. Interact. (2009) 178, 234-241. {Pubmed:19061875} ; PENTACON Notes: Mutant: mutant V244M. Residues 236-244, 262-277, 236-244/262-277 or 230 of CBR3 exchanged to the corresponding amino acids of CBR1 AAP, ASD 12/7/2011 1111 2200001700 Jodi P41222 5730 PTGDS Homo sapiens 9606 Comment/biophysicochemical properties/KM #4,13# 0.014 {(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate} (#4,13# pH 8.0 <65>) <65> 0.014 mM prostaglandin H2 CHEBI:15554 5.3.99.2 #4,13# pH 8.0 <65> Y Y ECO:0000006 Pubmed:19131342 BRENDA <65> Irikura, D.; Aritake, K.; Nagata, N.; Maruyama, T.; Shimamoto, S.;Urade, Y.: Biochemical, functional and pharmacological characterizationof AT-56, an orally active and selective inhibitor of lipocalin-typeprostaglandin d synthase. J. Biol. Chem. (2009) 284, 7623-7630.{Pubmed:19131342} AAP, DGA 12/7/2011 1111 2200001701 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #25# 0.287 {Doxorubicin} (#25# wild-type <77>) <77> 0.287 mM doxorubicin CHEBI:28748 1.1.1.184 #25# wild-type <77> Y Y ECO:0000006 Pubmed:19204081 BRENDA <77> Bains, O.S.; Karkling, M.J.; Grigliatti, T.A.; Reid, R.E.; Riggs,K.W.: Two nonsynonymous single nucleotide polymorphisms of humancarbonyl reductase 1 demonstrate reduced in vitro metabolism ofdaunorubicin and doxorubicin. Drug Metab. Dispos. (2009) 37, 1107-1114.{Pubmed:19204081} AAP, ASD 12/7/2011 1111 2200001702 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #25# 0.325 {Doxorubicin} (#25# single nucleotide polymorphism P131Smutation <77>) <77> 0.325 mM doxorubicin CHEBI:28748 1.1.1.184 #25# single nucleotide polymorphism P131Smutation <77> Y Y ECO:0000006 Pubmed:19204081 BRENDA <77> Bains, O.S.; Karkling, M.J.; Grigliatti, T.A.; Reid, R.E.; Riggs,K.W.: Two nonsynonymous single nucleotide polymorphisms of humancarbonyl reductase 1 demonstrate reduced in vitro metabolism ofdaunorubicin and doxorubicin. Drug Metab. Dispos. (2009) 37, 1107-1114.{Pubmed:19204081}; PENTACON Notes: Mutant: P131S mutation AAP, ASD 12/7/2011 1111 2200001703 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #25# 0.335 {Doxorubicin} (#25# single nucleotide polymorphism V88Imutation <77>) <77> 0.335 mM doxorubicin CHEBI:28748 1.1.1.184 #25# single nucleotide polymorphism V88Imutation <77> Y Y ECO:0000006 Pubmed:19204081 BRENDA <77> Bains, O.S.; Karkling, M.J.; Grigliatti, T.A.; Reid, R.E.; Riggs,K.W.: Two nonsynonymous single nucleotide polymorphisms of humancarbonyl reductase 1 demonstrate reduced in vitro metabolism ofdaunorubicin and doxorubicin. Drug Metab. Dispos. (2009) 37, 1107-1114.{Pubmed:19204081}; PENTACON Notes: Mutant: V88I mutation AAP, ASD 12/7/2011 1111 2200001704 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #25# 0.018 {menadione} (#25# single nucleotide polymorphism V88Imutation <77>) <77> 0.018 mM menadione CHEBI:28869 1.1.1.184 #25# single nucleotide polymorphism V88Imutation <77> Y Y ECO:0000006 Pubmed:19204081 BRENDA <77> Bains, O.S.; Karkling, M.J.; Grigliatti, T.A.; Reid, R.E.; Riggs,K.W.: Two nonsynonymous single nucleotide polymorphisms of humancarbonyl reductase 1 demonstrate reduced in vitro metabolism ofdaunorubicin and doxorubicin. Drug Metab. Dispos. (2009) 37, 1107-1114.{Pubmed:19204081}; PENTACON Notes: Mutant: V88I mutation AAP, ASD 12/7/2011 1111 2200001705 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #25# 0.024 {menadione} (#25# wild-type <77>) <77> 0.024 mM menadione CHEBI:28869 1.1.1.184 #25# wild-type <77> Y Y ECO:0000006 Pubmed:19204081 BRENDA <77> Bains, O.S.; Karkling, M.J.; Grigliatti, T.A.; Reid, R.E.; Riggs,K.W.: Two nonsynonymous single nucleotide polymorphisms of humancarbonyl reductase 1 demonstrate reduced in vitro metabolism ofdaunorubicin and doxorubicin. Drug Metab. Dispos. (2009) 37, 1107-1114.{Pubmed:19204081} AAP, ASD 12/7/2011 1111 2200001706 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #25# 0.045 {menadione} (#25# single nucleotide polymorphism P131Smutation <77>) <77> 0.045 mM menadione CHEBI:28869 1.1.1.184 #25# single nucleotide polymorphism P131Smutation <77> Y Y ECO:0000006 Pubmed:19204081 BRENDA <77> Bains, O.S.; Karkling, M.J.; Grigliatti, T.A.; Reid, R.E.; Riggs,K.W.: Two nonsynonymous single nucleotide polymorphisms of humancarbonyl reductase 1 demonstrate reduced in vitro metabolism ofdaunorubicin and doxorubicin. Drug Metab. Dispos. (2009) 37, 1107-1114.{Pubmed:19204081}; PENTACON Notes: Mutant: P131S mutation AAP, ASD 12/7/2011 1111 2200001707 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #25# 0.051 {daunorubicin} (#25# wild-type <77>) <77> 0.051 mM daunorubicin CHEBI:41977 1.1.1.184 #25# wild-type <77> Y Y ECO:0000006 Pubmed:19204081 BRENDA <77> Bains, O.S.; Karkling, M.J.; Grigliatti, T.A.; Reid, R.E.; Riggs,K.W.: Two nonsynonymous single nucleotide polymorphisms of humancarbonyl reductase 1 demonstrate reduced in vitro metabolism ofdaunorubicin and doxorubicin. Drug Metab. Dispos. (2009) 37, 1107-1114.{Pubmed:19204081} AAP, ASD 12/7/2011 1111 2200001708 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #25# 0.089 {daunorubicin} (#25# single nucleotide polymorphism P131Smutation <77>) <77> 0.089 mM daunorubicin CHEBI:41977 1.1.1.184 #25# single nucleotide polymorphism P131Smutation <77> Y Y ECO:0000006 Pubmed:19204081 BRENDA <77> Bains, O.S.; Karkling, M.J.; Grigliatti, T.A.; Reid, R.E.; Riggs,K.W.: Two nonsynonymous single nucleotide polymorphisms of humancarbonyl reductase 1 demonstrate reduced in vitro metabolism ofdaunorubicin and doxorubicin. Drug Metab. Dispos. (2009) 37, 1107-1114.{Pubmed:19204081}; PENTACON Notes: Mutant: P131S mutation AAP, ASD 12/7/2011 1111 2200001709 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 257 {doxorubicin} single nucleotide polymorphism V88I mutation 257.0 nmol/min/mg doxorubicin CHEBI:28748 Y Y ECO:0000006 Pubmed:19204081 PENTACON Added by PENTACON; PENTACON Notes: Mutant: V88I mutation AAP, ASD 4/21/2014 3 2200001710 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 325 {doxorubicin} single nucleotide polymorphism P131S mutation 325.0 nmol/min/mg doxorubicin CHEBI:28748 Y Y ECO:0000006 Pubmed:19204081 PENTACON Added by PENTACON; PENTACON Notes: Mutant: P131S mutation AAP, ASD 4/21/2014 3 2200001711 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 364 {doxorubicin} wild-type 364.0 nmol/min/mg doxorubicin CHEBI:28748 Y Y ECO:0000006 Pubmed:19204081 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001712 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 334 {menadione} single nucleotide polymorphism V88I mutation 334.0 nmol/min/mg menadione CHEBI:28869 Y Y ECO:0000006 Pubmed:19204081 PENTACON Added by PENTACON; PENTACON Notes: Mutant: V88I mutation AAP, ASD 4/21/2014 3 2200001713 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 537 {menadione} wild-type 537.0 nmol/min/mg menadione CHEBI:28869 Y Y ECO:0000006 Pubmed:19204081 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001714 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 581 {menadione} single nucleotide polymorphism P131S mutation 581.0 nmol/min/mg menadione CHEBI:28869 Y Y ECO:0000006 Pubmed:19204081 PENTACON Added by PENTACON; PENTACON Notes: Mutant: P131S mutation AAP, ASD 4/21/2014 3 2200001715 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #25# 0.051 {daunorubicin} (#25# single nucleotidepolymorphism V88I mutation <77>) <77> 0.051 mM daunorubicin CHEBI:41977 1.1.1.184 #25# single nucleotidepolymorphism V88I mutation <77> Y Y ECO:0000006 Pubmed:19204081 BRENDA <77> Bains, O.S.; Karkling, M.J.; Grigliatti, T.A.; Reid, R.E.; Riggs,K.W.: Two nonsynonymous single nucleotide polymorphisms of humancarbonyl reductase 1 demonstrate reduced in vitro metabolism ofdaunorubicin and doxorubicin. Drug Metab. Dispos. (2009) 37, 1107-1114.{Pubmed:19204081}; PENTACON Notes: Mutant: V88I mutation AAP, ASD 12/7/2011 1111 2200001716 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2090 {daunorubicin} single nucleotide polymorphism V88I mutation 2090.0 nmol/min/mg daunorubicin CHEBI:41977 Y Y ECO:0000006 Pubmed:19204081 PENTACON Added by PENTACON; PENTACON Notes: Mutant: V88I mutation AAP, ASD 4/21/2014 3 2200001717 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 3430 {daunorubicin} wild-type 3430.0 nmol/min/mg daunorubicin CHEBI:41977 Y Y ECO:0000006 Pubmed:19204081 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001718 Christie P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 3570 {daunorubicin} single nucleotide polymorphism P131S mutation 3570.0 nmol/min/mg daunorubicin CHEBI:41977 Y Y ECO:0000006 Pubmed:19204081 PENTACON Added by PENTACON; PENTACON Notes: Mutant: P131S mutation AAP, ASD 4/21/2014 3 2200001719 Christie P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.0055 {Linoleic acid} (#14# isozyme PGHS-1, in 100 mM Tris-HClbuffer (pH 7.4), at 24°C <73>) <73> 0.0055 mM linoleic acid CHEBI:17351 1.14.99.1 #14# isozyme PGHS-1, in 100 mM Tris-HClbuffer (pH 7.4), at 24°C <73> Y Y ECO:0000006 Pubmed:19457650 BRENDA <73> Kawakami, Y.; Nakamura, T.; Hosokawa, T.; Suzuki-Yamamoto, T.;Yamashita, H.; Kimoto, M.; Tsuji, H.; Yoshida, H.; Hada, T.; Takahashi,Y.: Antiproliferative activity of guava leaf extract via inhibition ofprostaglandin endoperoxide H synthase isoforms. Prostaglandins Leukot.Essent. Fatty Acids (2009) 80, 239-245. {Pubmed:19457650} AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001720 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #16# 0.0068 {Linoleic acid} (#16# isozyme PGHS-2, in 100 mM Tris-HClbuffer (pH 7.4), at 24°C <73>) <73> 0.0068 mM linoleic acid CHEBI:17351 1.14.99.1 #16# isozyme PGHS-2, in 100 mM Tris-HClbuffer (pH 7.4), at 24°C <73> Y Y ECO:0000006 Pubmed:19457650 BRENDA <73> Kawakami, Y.; Nakamura, T.; Hosokawa, T.; Suzuki-Yamamoto, T.;Yamashita, H.; Kimoto, M.; Tsuji, H.; Yoshida, H.; Hada, T.; Takahashi,Y.: Antiproliferative activity of guava leaf extract via inhibition ofprostaglandin endoperoxide H synthase isoforms. Prostaglandins Leukot.Essent. Fatty Acids (2009) 80, 239-245. {Pubmed:19457650} AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001721 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.0009 {arachidonate} (#14# purified isoform PGHS-2, method:coupled, homo-vanilic acid <66>) <66> 0.0009 mM arachidonate CHEBI:32395 Y Y ECO:0000033 Pubmed:19728984 PENTACON Added by PENTACON; PENTACON Notes: purified isoform PGHS-2, method:coupled, homo-vanilic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001722 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.0011 {arachidonate} (#14# purified isoform PGHS-2, method:direct, O2 <66>) <66> 0.0011 mM arachidonate CHEBI:32395 Y Y ECO:0000033 Pubmed:19728984 PENTACON Added by PENTACON; PENTACON Notes: purified isoform PGHS-2, method:direct, O2 AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001723 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.0017 {arachidonate} (#14# purified isoform PGHS-2, method:direct, O2 <66>) <66> 0.0017 mM arachidonate CHEBI:32395 Y Y ECO:0000033 Pubmed:19728984 PENTACON Added by PENTACON; PENTACON Notes: purified isoform PGHS-2, method:direct, O2 AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001724 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.002 {arachidonate} (#14# purified isoform PGHS-2, method:direct, O2 <66>) <66> 0.002 mM arachidonate CHEBI:32395 Y Y ECO:0000033 Pubmed:19728984 PENTACON Added by PENTACON; PENTACON Notes: purified isoform PGHS-2, method:direct, O2 AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001725 Jodi P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #16# 0.0045 {arachidonate} (#16# purified isoform PGHS-1, method:direct, O2 <66>) <66> 0.0045 mM arachidonate CHEBI:32395 Y Y ECO:0000033 Pubmed:19728984 PENTACON Added by PENTACON; PENTACON Notes: purified isoform PGHS-1, method:direct, O2 AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001726 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.005 {arachidonate} (#14# purified isoform PGHS-2, method:direct, O2 <66>) <66> 0.005 mM arachidonate CHEBI:32395 Y Y ECO:0000033 Pubmed:19728984 PENTACON Added by PENTACON; PENTACON Notes: purified isoform PGHS-2, method:direct, O2 AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001727 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.0051 {arachidonate} (#14# purified isoform PGHS-2, method:direct, O2 <66>) <66> 0.0051 mM arachidonate CHEBI:32395 Y Y ECO:0000033 Pubmed:19728984 PENTACON Added by PENTACON; PENTACON Notes: purified isoform PGHS-2, method:direct, O2 AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001728 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.009 {arachidonate} (#14# purified isoform PGHS-2, method:direct, O2 <66>) <66> 0.009 mM arachidonate CHEBI:32395 Y Y ECO:0000033 Pubmed:19728984 PENTACON Added by PENTACON; PENTACON Notes: purified isoform PGHS-2, method:direct, O2 AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001729 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.0092 {arachidonate} (#14# purified isoform PGHS-2, method:direct, O2 <66>) <66> 0.0092 mM arachidonate CHEBI:32395 Y Y ECO:0000033 Pubmed:19728984 PENTACON Added by PENTACON; PENTACON Notes: purified isoform PGHS-2, method:direct, O2 AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001730 Jodi P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #14# 0.01 {arachidonate} (#14# purified isoform PGHS-2, method:direct, arachidonate <66>; #14# purified isoform PGHS-2, method:direct, trimethyl phosphine oxide <66>) <66> 0.01 mM arachidonate CHEBI:32395 Y Y ECO:0000033 Pubmed:19728984 PENTACON Added by PENTACON; PENTACON Notes: purified isoform PGHS-2, method:direct, O2 AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001731 Jodi P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #16# 0.0102 {arachidonate} (#16# purified isoform PGHS-1, method:direct, arachidonate <66>) <66> 0.0102 mM arachidonate CHEBI:32395 Y Y ECO:0000033 Pubmed:19728984 PENTACON Added by PENTACON; PENTACON Notes: purified isoform PGHS-1, method:direct, O2 AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001732 Jodi P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.232 {NADPH} (#4# pH 6.0, 30°C, ALR2 <137>) <137> 0.232 mM NADPH CHEBI:16474 1.1.1.21 #4# pH 6.0, 30°C, ALR2 <137> Y Y ECO:0000006 Pubmed:19850041 BRENDA <137> Muthenna, P.; Suryanarayana, P.; Gunda, S.K.; Petrash, J.M.;Reddy, G.B.: Inhibition of aldose reductase by dietary antioxidantcurcumin: mechanism of inhibition, specificity and significance. FEBSLett. (2009) 583, 3637-3642. {Pubmed:19850041} AAP, DGA, ASD 12/7/2011 1111 2200001733 Jodi P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #4# 0.074 {NADPH} (#4# pH 6.0, 30°C, ALR2 <137>) <137> 0.074 umol/min/mg NADPH CHEBI:16474 Y Y ECO:0000006 Pubmed:19850041 PENTACON Added by PENTACON; PENTACON Notes: pH 6.0, 30°C, ALR2 AAP, DGA, ASD 4/21/2014 3 2200001734 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.215 {prostaglandin H2} (#2# wild type enzyme <80>) <80> 0.215 mM prostaglandin H2 CHEBI:15554 5.3.99.3 #2# wild type enzyme <80> Y Y ECO:0000006 Pubmed:20369883 BRENDA <80> Hamza, A.; Tong, M.; AbdulHameed, M.D.; Liu, J.; Goren, A.C.; Tai,H.H.; Zhan, C.G.: Understanding microscopic binding of human microsomalprostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 andcofactor GSH: insights from computational alanine scanning andsite-directed mutagenesis. J. Phys. Chem. B (2010) 114, 5605-5616.{Pubmed:20369883} AAP, DGA 12/7/2011 1111 2200001735 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.2832 {prostaglandin H2} (#2# mutant enzyme Y117S <80>) <80> 0.2832 mM prostaglandin H2 CHEBI:15554 5.3.99.3 #2# mutant enzyme Y117S <80> Y Y ECO:0000006 Pubmed:20369883 BRENDA <80> Hamza, A.; Tong, M.; AbdulHameed, M.D.; Liu, J.; Goren, A.C.; Tai,H.H.; Zhan, C.G.: Understanding microscopic binding of human microsomalprostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 andcofactor GSH: insights from computational alanine scanning andsite-directed mutagenesis. J. Phys. Chem. B (2010) 114, 5605-5616.{Pubmed:20369883}; PENTACON Notes: Mutant: Y117S AAP, DGA 12/7/2011 1111 2200001736 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.296 {prostaglandin H2} (#2# mutant enzyme R70A <80>) <80> 0.296 mM prostaglandin H2 CHEBI:15554 5.3.99.3 #2# mutant enzyme R70A <80> Y Y ECO:0000006 Pubmed:20369883 BRENDA <80> Hamza, A.; Tong, M.; AbdulHameed, M.D.; Liu, J.; Goren, A.C.; Tai,H.H.; Zhan, C.G.: Understanding microscopic binding of human microsomalprostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 andcofactor GSH: insights from computational alanine scanning andsite-directed mutagenesis. J. Phys. Chem. B (2010) 114, 5605-5616.{Pubmed:20369883}; PENTACON Notes: Mutant: R70A AAP, DGA 12/7/2011 1111 2200001737 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.372 {prostaglandin H2} (#2# mutant enzyme R122A <80>) <80> 0.372 mM prostaglandin H2 CHEBI:15554 5.3.99.3 #2# mutant enzyme R122A <80> Y Y ECO:0000006 Pubmed:20369883 BRENDA <80> Hamza, A.; Tong, M.; AbdulHameed, M.D.; Liu, J.; Goren, A.C.; Tai,H.H.; Zhan, C.G.: Understanding microscopic binding of human microsomalprostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 andcofactor GSH: insights from computational alanine scanning andsite-directed mutagenesis. J. Phys. Chem. B (2010) 114, 5605-5616.{Pubmed:20369883}; PENTACON Notes: Mutant: R122A AAP, DGA 12/7/2011 1111 2200001738 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.3842 {prostaglandin H2} (#2# mutant enzyme T129V <80>) <80> 0.3842 mM prostaglandin H2 CHEBI:15554 5.3.99.3 #2# mutant enzyme T129V <80> Y Y ECO:0000006 Pubmed:20369883 BRENDA <80> Hamza, A.; Tong, M.; AbdulHameed, M.D.; Liu, J.; Goren, A.C.; Tai,H.H.; Zhan, C.G.: Understanding microscopic binding of human microsomalprostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 andcofactor GSH: insights from computational alanine scanning andsite-directed mutagenesis. J. Phys. Chem. B (2010) 114, 5605-5616.{Pubmed:20369883}; PENTACON Notes: Mutant: T129V AAP, DGA 12/7/2011 1111 2200001739 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.4643 {prostaglandin H2} (#2# mutant enzyme N74A <80>) <80> 0.4643 mM prostaglandin H2 CHEBI:15554 5.3.99.3 #2# mutant enzyme N74A <80> Y Y ECO:0000006 Pubmed:20369883 BRENDA <80> Hamza, A.; Tong, M.; AbdulHameed, M.D.; Liu, J.; Goren, A.C.; Tai,H.H.; Zhan, C.G.: Understanding microscopic binding of human microsomalprostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 andcofactor GSH: insights from computational alanine scanning andsite-directed mutagenesis. J. Phys. Chem. B (2010) 114, 5605-5616.{Pubmed:20369883}; PENTACON Notes: Mutant: N74A AAP, DGA 12/7/2011 1111 2200001740 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.4737 {prostaglandin H2} (#2# mutant enzyme R70A/R122A <80>) <80> 0.4737 mM prostaglandin H2 CHEBI:15554 5.3.99.3 #2# mutant enzyme R70A/R122A <80> Y Y ECO:0000006 Pubmed:20369883 BRENDA <80> Hamza, A.; Tong, M.; AbdulHameed, M.D.; Liu, J.; Goren, A.C.; Tai,H.H.; Zhan, C.G.: Understanding microscopic binding of human microsomalprostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 andcofactor GSH: insights from computational alanine scanning andsite-directed mutagenesis. J. Phys. Chem. B (2010) 114, 5605-5616.{Pubmed:20369883}; PENTACON Notes: Mutant: R70A/R122A AAP, DGA 12/7/2011 1111 2200001741 Chandra O14684 9536 PTGES Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.5345 {prostaglandin H2} (#2# mutant enzyme Y117A <80>) <80> 0.5345 mM prostaglandin H2 CHEBI:15554 5.3.99.3 #2# mutant enzyme Y117A <80> Y Y ECO:0000006 Pubmed:20369883 BRENDA <80> Hamza, A.; Tong, M.; AbdulHameed, M.D.; Liu, J.; Goren, A.C.; Tai,H.H.; Zhan, C.G.: Understanding microscopic binding of human microsomalprostaglandin E synthase-1 (mPGES-1) trimer with substrate PGH2 andcofactor GSH: insights from computational alanine scanning andsite-directed mutagenesis. J. Phys. Chem. B (2010) 114, 5605-5616.{Pubmed:20369883}; PENTACON Notes: Mutant: Y117A AAP, DGA 12/7/2011 1111 2200001742 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 40 {D-galactose} <6> 40.0 mM D-galactose CHEBI:12936 1.1.1.21 Y Y ECO:0000006 Pubmed:6814912 BRENDA <6> Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.:Purification and characterization of human-brain aldose reductase. Eur.J. Biochem. (1982) 127, 279-284. {Pubmed:6814912} AAP, DGA, ASD 12/7/2011 1111 2200001743 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4,8# 5 {D-glucuronate} <6,12> 5.0 mM D-glucuronate CHEBI:15748 1.1.1.21 Y Y ECO:0000006 Pubmed:6814912 BRENDA <6> Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.:Purification and characterization of human-brain aldose reductase. Eur.J. Biochem. (1982) 127, 279-284. {Pubmed:6814912} AAP, DGA, ASD 12/7/2011 1111 2200001744 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.035 {D-glyceraldehyde} <6> 0.035 mM D-glyceraldehyde CHEBI:17378 1.1.1.21 Y Y ECO:0000006 Pubmed:6814912 BRENDA <6> Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.:Purification and characterization of human-brain aldose reductase. Eur.J. Biochem. (1982) 127, 279-284. {Pubmed:6814912} AAP, DGA, ASD 12/7/2011 1111 2200001745 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 95 {D-glucose} <6> 95.0 mM D-glucose CHEBI:17634 1.1.1.21 Y Y ECO:0000006 Pubmed:6814912 BRENDA <6> Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.:Purification and characterization of human-brain aldose reductase. Eur.J. Biochem. (1982) 127, 279-284. {Pubmed:6814912} AAP, DGA, ASD 12/7/2011 1111 2200001746 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.018 {L-Glyceraldehyde} (#4# recombinant from baculovirus systemwith Spodoptera frugiperda cells <26>) <6,26> 0.018 mM L-glyceraldehyde CHEBI:27975 1.1.1.21 #4# recombinant from baculovirus systemwith Spodoptera frugiperda cells <26> Y Y ECO:0000006 Pubmed:6814912 BRENDA <6> Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.:Purification and characterization of human-brain aldose reductase. Eur.J. Biochem. (1982) 127, 279-284. {Pubmed:6814912} AAP, DGA, ASD 12/7/2011 1111 2200001747 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.025 {DL-glyceraldehyde} <2,6> 0.025 mM glyceraldehyde CHEBI:5445 1.1.1.21 Y Y ECO:0000006 Pubmed:6814912 BRENDA <6> Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.:Purification and characterization of human-brain aldose reductase. Eur.J. Biochem. (1982) 127, 279-284. {Pubmed:6814912} AAP, DGA, ASD 12/7/2011 1111 2200001748 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 5.1 {D-xylose} <6> 5.1 mM D-xylose CHEBI:65327 1.1.1.21 Y Y ECO:0000006 Pubmed:6814912 BRENDA <6> Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.:Purification and characterization of human-brain aldose reductase. Eur.J. Biochem. (1982) 127, 279-284. {Pubmed:6814912} AAP, DGA, ASD 12/7/2011 1111 2200001749 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 100 {L-Xylose} <6> 100.0 mM L-xylose CHEBI:65328 1.1.1.21 Y Y ECO:0000006 Pubmed:6814912 BRENDA <6> Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.:Purification and characterization of human-brain aldose reductase. Eur.J. Biochem. (1982) 127, 279-284. {Pubmed:6814912} AAP, DGA, ASD 12/7/2011 1111 2200001750 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.002 {4-Nitrobenzaldehyde} <6> 0.002 mM 4-nitrobenzaldehyde CHEBI:66926 1.1.1.21 Y Y ECO:0000006 Pubmed:6814912 BRENDA <6> Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.:Purification and characterization of human-brain aldose reductase. Eur.J. Biochem. (1982) 127, 279-284. {Pubmed:6814912} AAP, DGA, ASD 12/7/2011 1111 2200001751 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4,22# 0.003 {4-Nitrobenzaldehyde} (#4# 4-hydroxyphenylglycolaldehyde<6>) <3,6> 0.003 mM 4-nitrobenzaldehyde CHEBI:66926 1.1.1.21 #4# 4-hydroxyphenylglycolaldehyde<6> Y Y ECO:0000006 Pubmed:6814912 BRENDA <6> Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.:Purification and characterization of human-brain aldose reductase. Eur.J. Biochem. (1982) 127, 279-284. {Pubmed:6814912} AAP, DGA, ASD 12/7/2011 1111 2200001752 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.01 {4-Hydroxyphenylacetaldehyde} <6> 0.01 mM (4-hydroxyphenyl)acetaldehyde CHEBI:15621 1.1.1.21 Y Y ECO:0000006 Pubmed:6814912 BRENDA <6> Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.:Purification and characterization of human-brain aldose reductase. Eur.J. Biochem. (1982) 127, 279-284. {Pubmed:6814912} AAP, DGA, ASD 12/7/2011 1111 2200001753 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.016 {Indole-3-acetaldehyde} <6> 0.016 mM indol-3-ylacetaldehyde CHEBI:18086 1.1.1.21 Y Y ECO:0000006 Pubmed:6814912 BRENDA <6> Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.:Purification and characterization of human-brain aldose reductase. Eur.J. Biochem. (1982) 127, 279-284. {Pubmed:6814912} AAP, DGA, ASD 12/7/2011 1111 2200001754 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.001 {20alpha-Isocorticosterone} (#4# and 20alpha-isocortisol,values below <6>) <6> 0.001 mM 20alpha-Isocorticosterone CHEBI:NONE_148518 1.1.1.21 #4# and 20alpha-isocortisol,values below <6> Y Y ECO:0000006 Pubmed:6814912 BRENDA <6> Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.:Purification and characterization of human-brain aldose reductase. Eur.J. Biochem. (1982) 127, 279-284. {Pubmed:6814912}; PENTACON Notes: Request ChEBI ID: 20alpha-Isocorticosterone AAP, DGA, ASD 12/7/2011 1111 2200001755 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.45 {prostaglandin E1} (#6# enzyme form CR8 <2>) <2> 0.45 mM prostaglandin E1 CHEBI:15544 1.1.1.184 #6# enzyme form CR8 <2> Y Y ECO:0000006 Pubmed:7005231 BRENDA <2> Wermuth, B.: Purification and properties of an NADPH-dependentcarbonyl reductase from human brain. Relationship to prostaglandin9-ketoreductase and xenobiotic ketone reductase. J. Biol. Chem. (1981)256, 1206-1213. {Pubmed:7005231} AAP, ASD 12/7/2011 1111 2200001756 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.004-0.01 {NADPH} (#6# + 4-nitrobenzaldehyde, Km depending onenzyme form <2>) <2> mM NADPH CHEBI:16474 1.1.1.184 #6# + 4-nitrobenzaldehyde, Km depending onenzyme form <2> Y Y ECO:0000006 Pubmed:7005231 BRENDA <2> Wermuth, B.: Purification and properties of an NADPH-dependentcarbonyl reductase from human brain. Relationship to prostaglandin9-ketoreductase and xenobiotic ketone reductase. J. Biol. Chem. (1981)256, 1206-1213. {Pubmed:7005231} AAP, ASD 12/7/2011 1111 2200001757 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.045-0.06 {menadione} (#6# Km depending on enzyme form <2>) <2> mM menadione CHEBI:28869 1.1.1.184 #6# Km depending on enzyme form <2> Y Y ECO:0000006 Pubmed:7005231 BRENDA <2> Wermuth, B.: Purification and properties of an NADPH-dependentcarbonyl reductase from human brain. Relationship to prostaglandin9-ketoreductase and xenobiotic ketone reductase. J. Biol. Chem. (1981)256, 1206-1213. {Pubmed:7005231} AAP, ASD 12/7/2011 1111 2200001758 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.13 {daunorubicin} (#6# enzyme form CR8 <2>) <2> 0.13 mM daunorubicin CHEBI:41977 1.1.1.184 #6# enzyme form CR8 <2> Y Y ECO:0000006 Pubmed:7005231 BRENDA <2> Wermuth, B.: Purification and properties of an NADPH-dependentcarbonyl reductase from human brain. Relationship to prostaglandin9-ketoreductase and xenobiotic ketone reductase. J. Biol. Chem. (1981)256, 1206-1213. {Pubmed:7005231} AAP, ASD 12/7/2011 1111 2200001759 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.015-0.017 {ubiquinone-1} (#6# Km depending on enzyme form <2>) <2> mM ubiquinone-1 CHEBI:46234 1.1.1.184 #6# Km depending on enzyme form <2> Y Y ECO:0000006 Pubmed:7005231 BRENDA <2> Wermuth, B.: Purification and properties of an NADPH-dependentcarbonyl reductase from human brain. Relationship to prostaglandin9-ketoreductase and xenobiotic ketone reductase. J. Biol. Chem. (1981)256, 1206-1213. {Pubmed:7005231} AAP, ASD 12/7/2011 1111 2200001760 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.6-2 {4-Nitrobenzaldehyde} (#6# Km depending on enzyme form <2>) <2> mM 4-nitrobenzaldehyde CHEBI:66926 1.1.1.184 #6# Km depending on enzyme form <2> Y Y ECO:0000006 Pubmed:7005231 BRENDA <2> Wermuth, B.: Purification and properties of an NADPH-dependentcarbonyl reductase from human brain. Relationship to prostaglandin9-ketoreductase and xenobiotic ketone reductase. J. Biol. Chem. (1981)256, 1206-1213. {Pubmed:7005231} AAP, ASD 12/7/2011 1111 2200001761 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 4-5 {Phenylglyoxal} (#6# Km depending on enzyme form <2>) <2> mM Phenylglyoxal CHEBI:NONE_148519 1.1.1.184 #6# Km depending on enzyme form <2> Y Y ECO:0000006 Pubmed:7005231 BRENDA <2> Wermuth, B.: Purification and properties of an NADPH-dependentcarbonyl reductase from human brain. Relationship to prostaglandin9-ketoreductase and xenobiotic ketone reductase. J. Biol. Chem. (1981)256, 1206-1213. {Pubmed:7005231}; PENTACON Notes: Request ChEBI ID: Phenylglyoxal, Puchem ID: CID 14090 AAP, ASD 12/7/2011 1111 2200001762 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #6# 0.1 {FAD} (#6# enzyme form CR8 <2>) <2> 0.1 mM FAD CHEBI:16238 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:7005231 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001763 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #6# 0.2 {dicoumarol} (#6# enzyme form CR8 <2>) <2> 0.2 mM dicoumarol CHEBI:4513 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:7005231 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001764 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #6# 0.005 {cibacron blue} (#6# enzyme form CR8 <2>) <2> 0.005 mM CIBACRON BLUE CHEBI:47301 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:7005231 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001765 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #6# 0.1 {indometacin} (#6# enzyme form CR8 <2>) <2> 0.1 mM indometacin CHEBI:49662 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:7005231 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001766 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 #6# 1 {iodoacetic acid} (#6# enzyme form CR8 <2>) <2> 1.0 mM iodoacetic acid CHEBI:74571 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:7005231 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001767 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 1.7 {prostaglandin E1} (#6# enzyme form CR8 <2>) <2> 1.7 nmol/min/mg prostaglandin E1 CHEBI:15544 Y Y ECO:0000006 Pubmed:7005231 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001768 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #6# 25 {daunorubicin} (#6# enzyme form CR8 <2>) <2> 25.0 nmol/min/mg daunorubicin CHEBI:41977 Y Y ECO:0000006 Pubmed:7005231 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001769 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4,17# 42.9 {D-galactose} (#4# recombinant from E. coli <25>) <20,25> 42.9 mM D-galactose CHEBI:12936 1.1.1.21 #4# recombinant from E. coli <25> Y Y ECO:0000006 Pubmed:7484387 BRENDA <25> Sato, S.; Old, S.; Carper, D.; Kador, P.F.: Purification andcharacterization of recombinant human placental and rat lens aldosereductases expressed in Escherichia coli. Enzymol. Mol. Biol. CarbonylMetab. (1995) 5, 259-268. {Pubmed:7484387} AAP, DGA, ASD 12/7/2011 1111 2200001770 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 46.7 {D-galactose} <25> 46.7 mM D-galactose CHEBI:12936 1.1.1.21 Y Y ECO:0000006 Pubmed:7484387 BRENDA <25> Sato, S.; Old, S.; Carper, D.; Kador, P.F.: Purification andcharacterization of recombinant human placental and rat lens aldosereductases expressed in Escherichia coli. Enzymol. Mol. Biol. CarbonylMetab. (1995) 5, 259-268. {Pubmed:7484387} AAP, DGA, ASD 12/7/2011 1111 2200001771 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 4.8 {D-glucuronate} <25> 4.8 mM D-glucuronate CHEBI:15748 1.1.1.21 Y Y ECO:0000006 Pubmed:7484387 BRENDA <25> Sato, S.; Old, S.; Carper, D.; Kador, P.F.: Purification andcharacterization of recombinant human placental and rat lens aldosereductases expressed in Escherichia coli. Enzymol. Mol. Biol. CarbonylMetab. (1995) 5, 259-268. {Pubmed:7484387} AAP, DGA, ASD 12/7/2011 1111 2200001772 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 6.4 {D-glucuronate} (#4# recombinant from E. coli <25>) <25> 6.4 mM D-glucuronate CHEBI:15748 1.1.1.21 #4# recombinant from E. coli <25> Y Y ECO:0000006 Pubmed:7484387 BRENDA <25> Sato, S.; Old, S.; Carper, D.; Kador, P.F.: Purification andcharacterization of recombinant human placental and rat lens aldosereductases expressed in Escherichia coli. Enzymol. Mol. Biol. CarbonylMetab. (1995) 5, 259-268. {Pubmed:7484387} AAP, DGA, ASD 12/7/2011 1111 2200001773 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 86.8 {D-glucose} <25> 86.8 mM D-glucose CHEBI:17634 1.1.1.21 Y Y ECO:0000006 Pubmed:7484387 BRENDA <25> Sato, S.; Old, S.; Carper, D.; Kador, P.F.: Purification andcharacterization of recombinant human placental and rat lens aldosereductases expressed in Escherichia coli. Enzymol. Mol. Biol. CarbonylMetab. (1995) 5, 259-268. {Pubmed:7484387} AAP, DGA, ASD 12/7/2011 1111 2200001774 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 98.1 {D-glucose} (#4# recombinant from E. coli <25>; #4#recombinant from baculovirus system in Spodoptera frugiperda cells<26>) <25,26> 98.1 mM D-glucose CHEBI:17634 1.1.1.21 #4# recombinant from E. coli <25>; #4#recombinant from baculovirus system in Spodoptera frugiperda cells<26> Y Y ECO:0000006 Pubmed:7484387 BRENDA <25> Sato, S.; Old, S.; Carper, D.; Kador, P.F.: Purification andcharacterization of recombinant human placental and rat lens aldosereductases expressed in Escherichia coli. Enzymol. Mol. Biol. CarbonylMetab. (1995) 5, 259-268. {Pubmed:7484387} AAP, DGA, ASD 12/7/2011 1111 2200001775 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.046 {DL-glyceraldehyde} <25> 0.046 mM glyceraldehyde CHEBI:5445 1.1.1.21 Y Y ECO:0000006 Pubmed:7484387 BRENDA <25> Sato, S.; Old, S.; Carper, D.; Kador, P.F.: Purification andcharacterization of recombinant human placental and rat lens aldosereductases expressed in Escherichia coli. Enzymol. Mol. Biol. CarbonylMetab. (1995) 5, 259-268. {Pubmed:7484387} AAP, DGA, ASD 12/7/2011 1111 2200001776 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.047 {DL-glyceraldehyde} (#4# recombinant from E. coli <25>) <25> 0.047 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# recombinant from E. coli <25> Y Y ECO:0000006 Pubmed:7484387 BRENDA <25> Sato, S.; Old, S.; Carper, D.; Kador, P.F.: Purification andcharacterization of recombinant human placental and rat lens aldosereductases expressed in Escherichia coli. Enzymol. Mol. Biol. CarbonylMetab. (1995) 5, 259-268. {Pubmed:7484387} AAP, DGA, ASD 12/7/2011 1111 2200001777 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 8.2 {D-xylose} <25> 8.2 mM D-xylose CHEBI:65327 1.1.1.21 Y Y ECO:0000006 Pubmed:7484387 BRENDA <25> Sato, S.; Old, S.; Carper, D.; Kador, P.F.: Purification andcharacterization of recombinant human placental and rat lens aldosereductases expressed in Escherichia coli. Enzymol. Mol. Biol. CarbonylMetab. (1995) 5, 259-268. {Pubmed:7484387} AAP, DGA, ASD 12/7/2011 1111 2200001778 Chandra P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 8.7 {D-xylose} (#4# recombinant from E. coli <25>) <25> 8.7 mM D-xylose CHEBI:65327 1.1.1.21 #4# recombinant from E. coli <25> Y Y ECO:0000006 Pubmed:7484387 BRENDA <25> Sato, S.; Old, S.; Carper, D.; Kador, P.F.: Purification andcharacterization of recombinant human placental and rat lens aldosereductases expressed in Escherichia coli. Enzymol. Mol. Biol. CarbonylMetab. (1995) 5, 259-268. {Pubmed:7484387} AAP, DGA, ASD 12/7/2011 1111 2200001779 Chandra P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0045 {arachidonic acid} (#3# isozyme 1 <34>) <34> 0.0045 mM arachidonic acid CHEBI:15843 1.14.99.1 #3# isozyme 1 <34> Y Y ECO:0000006 Pubmed:7947975 BRENDA <34> Barnett, J.; Chow, J.; Ives, D.; Chiou, M.; Mackenzie, R.; Osen,E.; Nguyen, B.; Tsing, S.; Bach, C.; Freire, J.; et al.: Purification,characterization and selective inhibition of human prostaglandin G/Hsynthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys.Acta (1994) 1209, 130-139. {Pubmed:7947975} AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001780 Chandra P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.005 {arachidonic acid} (#3# isozyme 2 <34>) <34> 0.005 mM arachidonic acid CHEBI:15843 1.14.99.1 #3# isozyme 2 <34> Y Y ECO:0000006 Pubmed:7947975 BRENDA <34> Barnett, J.; Chow, J.; Ives, D.; Chiou, M.; Mackenzie, R.; Osen,E.; Nguyen, B.; Tsing, S.; Bach, C.; Freire, J.; et al.: Purification,characterization and selective inhibition of human prostaglandin G/Hsynthase 1 and 2 expressed in the baculovirus system. Biochim. Biophys.Acta (1994) 1209, 130-139. {Pubmed:7947975} AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001781 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.1 {prostaglandin E2} <23> 0.1 mM prostaglandin E2 CHEBI:15551 1.1.1.184 Y Y ECO:0000006 Pubmed:7990149 BRENDA <23> Bohren, K.M.; Wermuth, B.; Harrison, D.; Ringe, D.; Petsko, G.A.;Gabbay, K.H.: Expression, crystallization and preliminarycrystallographic analysis of human carbonyl reductase. J. Mol. Biol.(1994) 244, 659-664. {Pubmed:7990149} AAP, ASD 12/7/2011 1111 2200001782 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.1 {5alpha-androstan-17beta-ol-3-one} <23> 0.1 mM 17beta-hydroxy-5alpha-androstan-3-one CHEBI:16330 1.1.1.184 Y Y ECO:0000006 Pubmed:7990149 BRENDA <23> Bohren, K.M.; Wermuth, B.; Harrison, D.; Ringe, D.; Petsko, G.A.;Gabbay, K.H.: Expression, crystallization and preliminarycrystallographic analysis of human carbonyl reductase. J. Mol. Biol.(1994) 244, 659-664. {Pubmed:7990149} AAP, ASD 12/7/2011 1111 2200001783 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.8 {2,3-Butanedione} <23> 1.8 mM butane-2,3-dione CHEBI:16583 1.1.1.184 Y Y ECO:0000006 Pubmed:7990149 BRENDA <23> Bohren, K.M.; Wermuth, B.; Harrison, D.; Ringe, D.; Petsko, G.A.;Gabbay, K.H.: Expression, crystallization and preliminarycrystallographic analysis of human carbonyl reductase. J. Mol. Biol.(1994) 244, 659-664. {Pubmed:7990149} AAP, ASD 12/7/2011 1111 2200001784 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.03 {menadione} <23> 0.03 mM menadione CHEBI:28869 1.1.1.184 Y Y ECO:0000006 Pubmed:7990149 BRENDA <23> Bohren, K.M.; Wermuth, B.; Harrison, D.; Ringe, D.; Petsko, G.A.;Gabbay, K.H.: Expression, crystallization and preliminarycrystallographic analysis of human carbonyl reductase. J. Mol. Biol.(1994) 244, 659-664. {Pubmed:7990149} AAP, ASD 12/7/2011 1111 2200001785 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.3 {daunorubicin} <23> 0.3 mM daunorubicin CHEBI:41977 1.1.1.184 Y Y ECO:0000006 Pubmed:7990149 BRENDA <23> Bohren, K.M.; Wermuth, B.; Harrison, D.; Ringe, D.; Petsko, G.A.;Gabbay, K.H.: Expression, crystallization and preliminarycrystallographic analysis of human carbonyl reductase. J. Mol. Biol.(1994) 244, 659-664. {Pubmed:7990149} AAP, ASD 12/7/2011 1111 2200001786 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.1 {4-Nitrobenzaldehyde} <23> 1.1 mM 4-nitrobenzaldehyde CHEBI:66926 1.1.1.184 Y Y ECO:0000006 Pubmed:7990149 BRENDA <23> Bohren, K.M.; Wermuth, B.; Harrison, D.; Ringe, D.; Petsko, G.A.;Gabbay, K.H.: Expression, crystallization and preliminarycrystallographic analysis of human carbonyl reductase. J. Mol. Biol.(1994) 244, 659-664. {Pubmed:7990149} AAP, ASD 12/7/2011 1111 2200001787 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.8 {2-Nitrobenzaldehyde} <23> 0.8 mM 2-nitrobenzaldehyde CHEBI:66927 1.1.1.184 Y Y ECO:0000006 Pubmed:7990149 BRENDA <23> Bohren, K.M.; Wermuth, B.; Harrison, D.; Ringe, D.; Petsko, G.A.;Gabbay, K.H.: Expression, crystallization and preliminarycrystallographic analysis of human carbonyl reductase. J. Mol. Biol.(1994) 244, 659-664. {Pubmed:7990149} AAP, ASD 12/7/2011 1111 2200001788 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.3 {benzoylpyridine} <23> 0.3 mM benzoylpyridine CHEBI:NONE_148521 1.1.1.184 Y Y ECO:0000006 Pubmed:7990149 BRENDA <23> Bohren, K.M.; Wermuth, B.; Harrison, D.; Ringe, D.; Petsko, G.A.;Gabbay, K.H.: Expression, crystallization and preliminarycrystallographic analysis of human carbonyl reductase. J. Mol. Biol.(1994) 244, 659-664. {Pubmed:7990149}; PENTACON Notes: Request ChEBI ID:benzoylpyridine, Puchem ID: CID 7038 AAP, ASD 12/7/2011 1111 2200001789 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1 {Phenylglyoxal} <23> 1.0 mM Phenylglyoxal CHEBI:NONE_148519 1.1.1.184 Y Y ECO:0000006 Pubmed:7990149 BRENDA <23> Bohren, K.M.; Wermuth, B.; Harrison, D.; Ringe, D.; Petsko, G.A.;Gabbay, K.H.: Expression, crystallization and preliminarycrystallographic analysis of human carbonyl reductase. J. Mol. Biol.(1994) 244, 659-664. {Pubmed:7990149}; PENTACON Notes: Request ChEBI ID: Phenylglyoxal, Puchem ID: CID 14090 AAP, ASD 12/7/2011 1111 2200001790 Jenn P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.4 {pyridine-4-carboxaldehyde} <23> 1.4 mM pyridine-4-carboxaldehyde CHEBI:NONE_148508 1.1.1.184 Y Y ECO:0000006 Pubmed:7990149 BRENDA <23> Bohren, K.M.; Wermuth, B.; Harrison, D.; Ringe, D.; Petsko, G.A.;Gabbay, K.H.: Expression, crystallization and preliminarycrystallographic analysis of human carbonyl reductase. J. Mol. Biol.(1994) 244, 659-664. {Pubmed:7990149}; PENTACON Notes: Request ChEBI ID: pyridine-4-carboxaldehyde, Puchem ID: CID 13389 AAP, ASD 12/7/2011 1111 2200001791 Jodi P41222 5730 PTGDS Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.004 {prostaglandin H2} <14> 0.004 mM prostaglandin H2 CHEBI:15554 5.3.99.2 Y Y ECO:0000006 Pubmed:8093029 BRENDA <14> Watanabe, K.; Urade, Y.; Mäder, M.; Murphy, C.; Hayaishi, O.:Identification of beta-trace as prostaglandin D synthase. Biochem.Biophys. Res. Commun. (1994) 203, 1110-1116. {Pubmed:8093029} (c) AAP, DGA 12/7/2011 1111 2200001792 Jodi P41222 5730 PTGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #4# 1000 {prostaglandin H2} <14> 1000.0 nmol/min/mg prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 Pubmed:8093029 PENTACON Added by PENTACON AAP, DGA 4/21/2014 3 2200001793 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.02 {DL-glyceraldehyde} <19> 0.02 mM glyceraldehyde CHEBI:5445 1.1.1.21 Y Y ECO:0000006 Pubmed:8117659 BRENDA <19> Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe,D.; Petsko, G.A.; Gabbay, K.H.: Tyrosine-48 is the proton donor andhistidine-110 directs substrate stereochemical selectivity in thereduction reaction of human aldose reductase: enzyme kinetics andcrystal structure of the Y48H mutant enzyme. Biochemistry (1994) 33,2021-2032. {Pubmed:8117659} AAP, DGA, ASD 12/7/2011 1111 2200001794 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 12 {DL-glyceraldehyde} (#4# mutant H110Q <19>) <19> 12.0 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# mutant H110Q <19> Y Y ECO:0000006 Pubmed:8117659 BRENDA <19> Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe,D.; Petsko, G.A.; Gabbay, K.H.: Tyrosine-48 is the proton donor andhistidine-110 directs substrate stereochemical selectivity in thereduction reaction of human aldose reductase: enzyme kinetics andcrystal structure of the Y48H mutant enzyme. Biochemistry (1994) 33,2021-2032. {Pubmed:8117659}; PENTACON Notes: Mutant: H110Q mutant AAP, DGA, ASD 12/7/2011 1111 2200001795 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 64 {DL-glyceraldehyde} (#4# mutant Y48S <19>) <19> 64.0 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# mutant Y48S <19> Y Y ECO:0000006 Pubmed:8117659 BRENDA <19> Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe,D.; Petsko, G.A.; Gabbay, K.H.: Tyrosine-48 is the proton donor andhistidine-110 directs substrate stereochemical selectivity in thereduction reaction of human aldose reductase: enzyme kinetics andcrystal structure of the Y48H mutant enzyme. Biochemistry (1994) 33,2021-2032. {Pubmed:8117659}; PENTACON Notes: Mutant: Y48S mutant AAP, DGA, ASD 12/7/2011 1111 2200001796 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 71 {DL-glyceraldehyde} (#4# mutant Y48H <19>) <19> 71.0 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# mutant Y48H <19> Y Y ECO:0000006 Pubmed:8117659 BRENDA <19> Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe,D.; Petsko, G.A.; Gabbay, K.H.: Tyrosine-48 is the proton donor andhistidine-110 directs substrate stereochemical selectivity in thereduction reaction of human aldose reductase: enzyme kinetics andcrystal structure of the Y48H mutant enzyme. Biochemistry (1994) 33,2021-2032. {Pubmed:8117659}; PENTACON Notes: Mutant: Y48H mutant AAP, DGA, ASD 12/7/2011 1111 2200001797 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 84 {DL-glyceraldehyde} (#4# mutant H110A <19>) <19> 84.0 mM glyceraldehyde CHEBI:5445 1.1.1.21 #4# mutant H110A <19> Y Y ECO:0000006 Pubmed:8117659 BRENDA <19> Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe,D.; Petsko, G.A.; Gabbay, K.H.: Tyrosine-48 is the proton donor andhistidine-110 directs substrate stereochemical selectivity in thereduction reaction of human aldose reductase: enzyme kinetics andcrystal structure of the Y48H mutant enzyme. Biochemistry (1994) 33,2021-2032. {Pubmed:8117659}; PENTACON Notes: Mutant: H110A mutant AAP, DGA, ASD 12/7/2011 1111 2200001798 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 506 {D-Lyxose} (#4# mutant H110Q <19>) <19> 506.0 mM D-lyxose CHEBI:62318 1.1.1.21 #4# mutant H110Q <19> Y Y ECO:0000006 Pubmed:8117659 BRENDA <19> Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe,D.; Petsko, G.A.; Gabbay, K.H.: Tyrosine-48 is the proton donor andhistidine-110 directs substrate stereochemical selectivity in thereduction reaction of human aldose reductase: enzyme kinetics andcrystal structure of the Y48H mutant enzyme. Biochemistry (1994) 33,2021-2032. {Pubmed:8117659}; PENTACON Notes: Mutant: H110Q mutant AAP, DGA, ASD 12/7/2011 1111 2200001799 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 2630 {D-Lyxose} <19> 2630.0 mM D-lyxose CHEBI:62318 1.1.1.21 Y Y ECO:0000006 Pubmed:8117659 BRENDA <19> Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe,D.; Petsko, G.A.; Gabbay, K.H.: Tyrosine-48 is the proton donor andhistidine-110 directs substrate stereochemical selectivity in thereduction reaction of human aldose reductase: enzyme kinetics andcrystal structure of the Y48H mutant enzyme. Biochemistry (1994) 33,2021-2032. {Pubmed:8117659} AAP, DGA, ASD 12/7/2011 1111 2200001800 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 2740 {D-Lyxose} (#4# mutant H110A <19>) <19> 2740.0 mM D-lyxose CHEBI:62318 1.1.1.21 #4# mutant H110A <19> Y Y ECO:0000006 Pubmed:8117659 BRENDA <19> Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe,D.; Petsko, G.A.; Gabbay, K.H.: Tyrosine-48 is the proton donor andhistidine-110 directs substrate stereochemical selectivity in thereduction reaction of human aldose reductase: enzyme kinetics andcrystal structure of the Y48H mutant enzyme. Biochemistry (1994) 33,2021-2032. {Pubmed:8117659}; PENTACON Notes: Mutant: H110A mutant AAP, DGA, ASD 12/7/2011 1111 2200001801 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 7.4 {D-xylose} <19> 7.4 mM D-xylose CHEBI:65327 1.1.1.21 Y Y ECO:0000006 Pubmed:8117659 BRENDA <19> Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe,D.; Petsko, G.A.; Gabbay, K.H.: Tyrosine-48 is the proton donor andhistidine-110 directs substrate stereochemical selectivity in thereduction reaction of human aldose reductase: enzyme kinetics andcrystal structure of the Y48H mutant enzyme. Biochemistry (1994) 33,2021-2032. {Pubmed:8117659} AAP, DGA, ASD 12/7/2011 1111 2200001802 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 861 {D-xylose} (#4# mutant H110Q <19>) <19> 861.0 mM D-xylose CHEBI:65327 1.1.1.21 #4# mutant H110Q <19> Y Y ECO:0000006 Pubmed:8117659 BRENDA <19> Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe,D.; Petsko, G.A.; Gabbay, K.H.: Tyrosine-48 is the proton donor andhistidine-110 directs substrate stereochemical selectivity in thereduction reaction of human aldose reductase: enzyme kinetics andcrystal structure of the Y48H mutant enzyme. Biochemistry (1994) 33,2021-2032. {Pubmed:8117659}; PENTACON Notes: Mutant: H110Q mutant AAP, DGA, ASD 12/7/2011 1111 2200001803 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 1340 {D-xylose} (#4# mutant H110A <19>) <19> 1340.0 mM D-xylose CHEBI:65327 1.1.1.21 #4# mutant H110A <19> Y Y ECO:0000006 Pubmed:8117659 BRENDA <19> Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe,D.; Petsko, G.A.; Gabbay, K.H.: Tyrosine-48 is the proton donor andhistidine-110 directs substrate stereochemical selectivity in thereduction reaction of human aldose reductase: enzyme kinetics andcrystal structure of the Y48H mutant enzyme. Biochemistry (1994) 33,2021-2032. {Pubmed:8117659}; PENTACON Notes: Mutant: H110A mutant AAP, DGA, ASD 12/7/2011 1111 2200001804 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 111 {L-Xylose} <19> 111.0 mM L-xylose CHEBI:65328 1.1.1.21 Y Y ECO:0000006 Pubmed:8117659 BRENDA <19> Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe,D.; Petsko, G.A.; Gabbay, K.H.: Tyrosine-48 is the proton donor andhistidine-110 directs substrate stereochemical selectivity in thereduction reaction of human aldose reductase: enzyme kinetics andcrystal structure of the Y48H mutant enzyme. Biochemistry (1994) 33,2021-2032. {Pubmed:8117659} AAP, DGA, ASD 12/7/2011 1111 2200001805 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 360 {L-Xylose} (#4# mutant H110A <19>) <19> 360.0 mM L-xylose CHEBI:65328 1.1.1.21 #4# mutant H110A <19> Y Y ECO:0000006 Pubmed:8117659 BRENDA <19> Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe,D.; Petsko, G.A.; Gabbay, K.H.: Tyrosine-48 is the proton donor andhistidine-110 directs substrate stereochemical selectivity in thereduction reaction of human aldose reductase: enzyme kinetics andcrystal structure of the Y48H mutant enzyme. Biochemistry (1994) 33,2021-2032. {Pubmed:8117659}; PENTACON Notes: Mutant: H110A mutant AAP, DGA, ASD 12/7/2011 1111 2200001806 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 1190 {L-Xylose} (#4# mutant H110Q <19>) <19> 1190.0 mM L-xylose CHEBI:65328 1.1.1.21 #4# mutant H110Q <19> Y Y ECO:0000006 Pubmed:8117659 BRENDA <19> Bohren, K.M.; Grimshaw, C.E.; Lai, C.J.; Harrison, D.H.; Ringe,D.; Petsko, G.A.; Gabbay, K.H.: Tyrosine-48 is the proton donor andhistidine-110 directs substrate stereochemical selectivity in thereduction reaction of human aldose reductase: enzyme kinetics andcrystal structure of the Y48H mutant enzyme. Biochemistry (1994) 33,2021-2032. {Pubmed:8117659}; PENTACON Notes: Mutant: H110Q mutant AAP, DGA, ASD 12/7/2011 1111 2200001807 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM .004 {4-nitrobenzaldehyde} 0.004 mM 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:8117659 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001808 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM .1 {4-nitrobenzaldehyde} mutant Y48H 0.1 mM 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:8117659 PENTACON Added by PENTACON; PENTACON Notes: Mutant: Y48H mutant AAP, DGA, ASD 4/21/2014 3 2200001809 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM .19 {4-nitrobenzaldehyde} mutant H110A 0.19 mM 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:8117659 PENTACON Added by PENTACON; PENTACON Notes: Mutant: H110A mutant AAP, DGA, ASD 4/21/2014 3 2200001810 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM .86 {4-nitrobenzaldehyde} mutant H110Q 0.86 mM 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:8117659 PENTACON Added by PENTACON; PENTACON Notes: Mutant: H110Q mutant AAP, DGA, ASD 4/21/2014 3 2200001811 Christie P15121 231 AKR1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM .88 {4-nitrobenzaldehyde} mutant Y48S 0.88 mM 4-nitrobenzaldehyde CHEBI:66926 Y Y ECO:0000006 Pubmed:8117659 PENTACON Added by PENTACON; PENTACON Notes: Mutant: Y48S mutant AAP, DGA, ASD 4/21/2014 3 2200001812 Chandra P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.001 {arachidonic acid} (#3# isozyme 1 and 2 <28>) <28> 0.001 mM arachidonic acid CHEBI:15843 1.14.99.1 #3# isozyme 1 and 2 <28> Y Y ECO:0000006 Pubmed:8831731 BRENDA <28> Kargman, S.; Wong, E.; Greig, G.M.; Falgueyret, J.P.; Cromlish,W.; Ethier, D.; Yergey, J.A.; Riendeau, D.; Evans, J.F.; Kennedy, B.;Tagari, P.; Francis, D.A.; O'Neill, G.P.: Mechanism of selectiveinhibition of human prostaglandin G/H synthase-1 and -2 in intactcells. Biochem. Pharmacol. (1996) 52, 1113-1125. {Pubmed:8831731} AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001813 Chandra P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.001 {arachidonic acid} (#3# isozyme 1 and 2 <28>) <28> 0.001 mM arachidonic acid CHEBI:15843 1.14.99.1 #3# isozyme 1 and 2 <28> Y Y ECO:0000006 Pubmed:8831731 BRENDA <28> Kargman, S.; Wong, E.; Greig, G.M.; Falgueyret, J.P.; Cromlish,W.; Ethier, D.; Yergey, J.A.; Riendeau, D.; Evans, J.F.; Kennedy, B.;Tagari, P.; Francis, D.A.; O'Neill, G.P.: Mechanism of selectiveinhibition of human prostaglandin G/H synthase-1 and -2 in intactcells. Biochem. Pharmacol. (1996) 52, 1113-1125. {Pubmed:8831731} AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001814 Chandra P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.0074 {arachidonic acid} 0.0074 mM arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:8831731 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001815 Chandra P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.015 {arachidonic acid} <31> 0.015 mM arachidonic acid CHEBI:15843 1.14.99.1 Y Y ECO:0000006 Pubmed:9172778 BRENDA <31> George, H.J.; Van Dyk, D.E.; Straney, R.A.; Trzaskos, J.M.;Copeland, R.A.: Expression purification and characterization ofrecombinant human inducible prostaglandin G/H synthase frombaculovirus-infected insect cells. Protein Expr. Purif. (1996) 7,19-26. {Pubmed:9172778} AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001816 Chandra P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.006 {arachidonic acid} <29> 0.006 mM arachidonic acid CHEBI:15843 1.14.99.1 Y Y ECO:0000006 Pubmed:9866686 BRENDA <29> Forghani, F.; Ouellet, M.; Keen, S.; Percival, M.D.; Tagari, P.:Analysis of prostaglandin G/H synthase-2 inhibition usingperoxidase-induced luminol luminescence. Anal. Biochem. (1998) 264,216-221. {Pubmed:9866686} AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200001817 Jenn O15296 247 ALOX15B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2000 {arachidonic acid} (splice variant 15-LOb2) 2000.0 nmol/min/mg arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:10542053 PENTACON Added by PENTACON; PENTACON Notes: splice variant 15-LOb2 AAP 4/21/2014 3 2200001818 Jenn O15296 247 ALOX15B Homo sapiens 9606 Comment/biophysicochemical properties/IC50 >1 {CDP-choline} (splice variant 15-LOb2) mM CDP-choline CHEBI:16436 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:10542053 PENTACON Added by PENTACON; PENTACON Notes: splice variant 15-LOb2 AAP 4/21/2014 3 2200001819 Jenn O15296 247 ALOX15B Homo sapiens 9606 Comment/biophysicochemical properties/IC50 >1 {nordihydroguaiaretic acid} (splice variant 15-LOb2) mM nordihydroguaiaretic acid CHEBI:7625 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:10542053 PENTACON Added by PENTACON; PENTACON Notes: splice variant 15-LOb2 AAP 4/21/2014 3 2200001820 Jenn O15296 247 ALOX15B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 4000 {arachidonic acid} (splice variant 15-LOb1) 4000.0 nmol/min/mg arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:10542053 PENTACON Added by PENTACON; PENTACON Notes: splice variant 15-LOb1 AAP 4/21/2014 3 2200001821 Jenn O15296 247 ALOX15B Homo sapiens 9606 Comment/biophysicochemical properties/IC50 0.0085 {CDP-choline} (splice variant 15-LOb1) 0.0085 mM CDP-choline CHEBI:16436 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:10542053 PENTACON Added by PENTACON; PENTACON Notes: splice variant 15-LOb1 AAP 4/21/2014 3 2200001822 Jenn O15296 247 ALOX15B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 4000 {lipoic acid} (splice variant 15-LOb1) 4000.0 nmol/min/mg lipoic acid CHEBI:16494 Y Y ECO:0000006 Pubmed:10542053 PENTACON Added by PENTACON; PENTACON Notes: splice variant 15-LOb1 AAP 4/21/2014 3 2200001823 Jenn O15296 247 ALOX15B Homo sapiens 9606 Comment/biophysicochemical properties/IC50 0.0769 {nordihydroguaiaretic acid} (splice variant 15-LOb1) 0.0769 mM nordihydroguaiaretic acid CHEBI:7625 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:10542053 PENTACON Added by PENTACON; PENTACON Notes: splice variant 15-LOb1 AAP 4/21/2014 3 2200001824 Jenn O15296 247 ALOX15B Homo sapiens 9606 Comment/biophysicochemical properties/IC50 >1 {Eicosatetraynoic acid} (splice variant 15-LOb2) mM Eicosatetraynoic acid CHEBI:NONE_148522 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:10542053 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: Eicosatetraynoic acid; Pubchem ID: CID 135235; splice variant 15-LOb2 AAP 4/21/2014 3 2200001825 Jenn O15296 247 ALOX15B Homo sapiens 9606 Comment/biophysicochemical properties/IC50 0.180 {Eicosatetraynoic acid} (splice variant 15-LOb1) 0.18 mM Eicosatetraynoic acid CHEBI:NONE_148522 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:10542053 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: Eicosatetraynoic acid; Pubchem ID: CID 135235; splice variant 15-LOb1 AAP 4/21/2014 3 2200001826 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 .0065 {Eicosatetraynoic acid} 0.0065 mM Eicosatetraynoic acid CHEBI:NONE_148522 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:10542053 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: Eicosatetraynoic acid; Pubchem ID: CID 135235 AAP, DGA, ASD 4/21/2014 3 2200001827 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 .0033 {CDP-choline} 0.0033 mM CDP-choline CHEBI:16436 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:10542053 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001828 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 .023 {nordihydroguaiaretic acid} 0.023 mM nordihydroguaiaretic acid CHEBI:7625 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:10542053 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001829 Jenn O15296 247 ALOX15B Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 1.1 {arachidonic acid} (#2# splice variant 15-LOb2 <29>) <29> 1.1 mM arachidonic acid CHEBI:15843 1.13.11.33 #2# splice variant 15-LOb2 <29> Y Y ECO:0000006 Pubmed:10542053 BRENDA <29> Kilty, I.; Logan, A.; Vickers, P.J.: Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase. Eur. J. Biochem. (1999) 266, 83-93. {Pubmed:10542053} AAP 12/7/2011 1111 2200001830 Jenn O15296 247 ALOX15B Homo sapiens 9606 Comment/biophysicochemical properties/KM #2,10# 0.025 {arachidonic acid} (#2# splice variant 15-LOb1 <29>) <7,29> 0.025 mM arachidonic acid CHEBI:15843 1.13.11.33 #2# splice variant 15-LOb1 <29> Y Y ECO:0000006 Pubmed:10542053 BRENDA <29> Kilty, I.; Logan, A.; Vickers, P.J.: Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase. Eur. J. Biochem. (1999) 266, 83-93. {Pubmed:10542053} AAP 12/7/2011 1111 2200001831 Jenn O15296 247 ALOX15B Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.01 {lipoic acid} (#2# splice variant 15-LOb1 <29>) <29> 0.01 mM lipoic acid CHEBI:16494 1.13.11.33 #2# splice variant 15-LOb1 <29> Y Y ECO:0000006 Pubmed:10542053 BRENDA <29> Kilty, I.; Logan, A.; Vickers, P.J.: Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase. Eur. J. Biochem. (1999) 266, 83-93. {Pubmed:10542053} AAP 12/7/2011 1111 2200001832 Jenn P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 40 {trans-diphenylpropene oxide} ( pH 7.4, 37°C ) 40.0 nmol/min/mg trans-diphenylpropene oxide CHEBI:NONE_148523 Y Y ECO:0000006 Pubmed:10568695 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: trans-diphenylpropene oxide; pH 7.4, 37°C AAP, DGA, ASD 4/21/2014 3 2200001833 Jenn P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.0081 {trans-diphenylpropene oxide} (#6# pH 7.4, 37°C <66>) <66> 0.0081 mM trans-diphenylpropene oxide CHEBI:NONE_148523 3.3.2.10 #6# pH 7.4, 37°C <66> Y Y ECO:0000006 Pubmed:10568695 BRENDA <66> Draper, A.J.; Hammock, B.D.: Inhibition of soluble and microsomal epoxide hydrolase by zinc and other metals. Toxicol. Sci. (1999) 52, 26-32. {Pubmed:10568695}; PENTACON NOTES: Request ChEBI ID: trans-diphenylpropene oxide AAP, DGA, ASD 12/7/2011 1111 2200001834 Jenn P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/IC50 0.00002 {thioamine} ( pH 7.5, 22°C) 2e-05 mM thioamine CHEBI:NONE_148524 leucine-4-nitroanilide CHEBI:NONE_148525 Y Y ECO:0000006 Pubmed:10574934 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: thioamine; pH 7.5, 22°C AAP, ASD 4/21/2014 3 2200001835 Jenn P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 310 {leucine-4-nitroanilide} ( pH 7.5, 22°C) 310.0 nmol/min/mg leucine-4-nitroanilide CHEBI:NONE_148525 Y Y ECO:0000006 Pubmed:10574934 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: leucine-4-nitroanilide; pH 7.5, 22°C AAP, ASD 4/21/2014 3 2200001836 Jenn P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/IC50 0.0005 {bestatin} ( pH 7.5, 22°C) 0.0005 mM bestatin CHEBI:NONE_148526 leucine-4-nitroanilide CHEBI:NONE_148525 Y Y ECO:0000006 Pubmed:10574934 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: bestatin, Chembl ID: CHEMBL29292; pH 7.5, 22°C AAP, ASD 4/21/2014 3 2200001837 Jenn P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/IC50 0.00003 {hydroxamic acid} ( pH 7.5, 22°C) 3e-05 mM hydroxamic acid CHEBI:24650 leucine-4-nitroanilide CHEBI:NONE_148525 Y Y ECO:0000006 Pubmed:10574934 PENTACON Added by PENTACON; PENTACON Notes: pH 7.5, 22°C AAP, ASD 4/21/2014 3 2200001838 Jenn P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.15 {leucine-4-nitroanilide} (#4# pH 7.5, 22°C <32>) <32> 0.15 mM leucine-4-nitroanilide CHEBI:NONE_148525 3.3.2.6 #4# pH 7.5, 22°C <32> Y Y ECO:0000006 Pubmed:10574934 BRENDA <32> Kull, F.; Ohlson, E.; Haeggstrom, J.Z.: Cloning and characterization of a bifunctional leukotriene A4 hydrolase from Saccharomyces cerevisiae. J. Biol. Chem. (1999) 274, 34683-34690. {Pubmed:10574934}; PENTACON Notes: Request ChEBI ID: leucine-4-nitroanilide AAP, ASD 12/7/2011 1111 2200001839 Jenn O00154 11332 ACOT7 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 270000 {arachidoyl-CoA} (#41# pH 7.4, 30°C <52>) <52> 270000.0 nmol/min/mg icosanoyl-CoA CHEBI:15527 Y Y ECO:0000006 Pubmed:10578051 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 30°C AAP, ASD 4/21/2014 3 2200001840 Jenn O00154 11332 ACOT7 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 295000 {Dodecanoyl-CoA} (#41# pH 7.4, 30°C <52>) <52> 295000.0 nmol/min/mg lauroyl-CoA CHEBI:15521 Y Y ECO:0000006 Pubmed:10578051 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 30°C AAP, ASD 4/21/2014 3 2200001841 Jenn O00154 11332 ACOT7 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 269000 {Octanoyl-CoA} (pH 7.4, 30°C) 269000.0 nmol/min/mg octanoyl-CoA CHEBI:15533 Y Y ECO:0000006 Pubmed:10578051 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 30°C AAP, ASD 4/21/2014 3 2200001842 Jenn O00154 11332 ACOT7 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 50000 {oleoyl-CoA} (#41# pH 7.4, 30°C <52>) <52> 50000.0 nmol/min/mg oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 Pubmed:10578051 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 30°C AAP, ASD 4/21/2014 3 2200001843 Jenn O00154 11332 ACOT7 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 275000 {hexadecanoyl-CoA} (#41# pH 7.4, 30°C <52>) <52> 275000.0 nmol/min/mg palmitoyl-CoA CHEBI:15525 Y Y ECO:0000006 Pubmed:10578051 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 30°C AAP, ASD 4/21/2014 3 2200001844 Jenn O00154 11332 ACOT7 Homo sapiens 9606 Comment/biophysicochemical properties/KM #41# 0.0092 {arachidoyl-CoA} (#41# pH 7.4, 30°C <52>) <52> 0.0092 mM icosanoyl-CoA CHEBI:15527 3.1.2.2 #41# pH 7.4, 30°C <52> Y Y ECO:0000006 Pubmed:10578051 BRENDA <52> Yamada, J.; Kurata, A.; Hirata, M.; Taniguchi, T.; Takama, H.; Furihata, T.; Shiratori, K.; Iida, N.; Takagi-Sakuma, M.; Watanabe, T.; Kurosaki, K.; Endo, T.; Suga, T.: Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. J. Biochem. (1999) 126, 1013-1019. {Pubmed:10578051} AAP, ASD 12/7/2011 1111 2200001845 Jenn O00154 11332 ACOT7 Homo sapiens 9606 Comment/biophysicochemical properties/KM #41# 0.0076 {Dodecanoyl-CoA} (#41# pH 7.4, 30°C <52>) <52> 0.0076 mM lauroyl-CoA CHEBI:15521 3.1.2.2 #41# pH 7.4, 30°C <52> Y Y ECO:0000006 Pubmed:10578051 BRENDA <52> Yamada, J.; Kurata, A.; Hirata, M.; Taniguchi, T.; Takama, H.; Furihata, T.; Shiratori, K.; Iida, N.; Takagi-Sakuma, M.; Watanabe, T.; Kurosaki, K.; Endo, T.; Suga, T.: Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. J. Biochem. (1999) 126, 1013-1019. {Pubmed:10578051} AAP, ASD 12/7/2011 1111 2200001846 Jenn O00154 11332 ACOT7 Homo sapiens 9606 Comment/biophysicochemical properties/KM #41# 0.014 {Octanoyl-CoA} (#41# pH 7.4, 30°C <52>) <52> 0.014 mM octanoyl-CoA CHEBI:15533 3.1.2.2 #41# pH 7.4, 30°C <52> Y Y ECO:0000006 Pubmed:10578051 BRENDA <52> Yamada, J.; Kurata, A.; Hirata, M.; Taniguchi, T.; Takama, H.; Furihata, T.; Shiratori, K.; Iida, N.; Takagi-Sakuma, M.; Watanabe, T.; Kurosaki, K.; Endo, T.; Suga, T.: Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. J. Biochem. (1999) 126, 1013-1019. {Pubmed:10578051} AAP, ASD 12/7/2011 1111 2200001847 Jenn O00154 11332 ACOT7 Homo sapiens 9606 Comment/biophysicochemical properties/KM #41# 0.0088 {oleoyl-CoA} (#41# pH 7.4, 30°C <52>) <52> 0.0088 mM oleoyl-CoA CHEBI:15534 3.1.2.2 #41# pH 7.4, 30°C <52> Y Y ECO:0000006 Pubmed:10578051 BRENDA <52> Yamada, J.; Kurata, A.; Hirata, M.; Taniguchi, T.; Takama, H.; Furihata, T.; Shiratori, K.; Iida, N.; Takagi-Sakuma, M.; Watanabe, T.; Kurosaki, K.; Endo, T.; Suga, T.: Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. J. Biochem. (1999) 126, 1013-1019. {Pubmed:10578051} AAP, ASD 12/7/2011 1111 2200001848 Jenn O00154 11332 ACOT7 Homo sapiens 9606 Comment/biophysicochemical properties/KM #41# 0.0064 {hexadecanoyl-CoA} (#41# pH 7.4, 30°C <52>) <52> 0.0064 mM palmitoyl-CoA CHEBI:15525 3.1.2.2 #41# pH 7.4, 30°C <52> Y Y ECO:0000006 Pubmed:10578051 BRENDA <52> Yamada, J.; Kurata, A.; Hirata, M.; Taniguchi, T.; Takama, H.; Furihata, T.; Shiratori, K.; Iida, N.; Takagi-Sakuma, M.; Watanabe, T.; Kurosaki, K.; Endo, T.; Suga, T.: Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase. J. Biochem. (1999) 126, 1013-1019. {Pubmed:10578051} AAP, ASD 12/7/2011 1111 2200001849 Christie Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0099 {leukotriene A4} <3> 0.0099 mM leukotriene A4 CHEBI:15651 4.4.1.20 Y Y ECO:0000033 Pubmed:10591082 BRENDA <3> Penrose, J.F.; Austen, K.F.: The biochemical, molecular, and genomic aspects of leukotriene C4 synthase. Proc. Assoc. Am. Phys. (1999) 111, 537-546. {Pubmed:} (c) AAP, DGA, ASD 12/7/2011 1111 2200001850 Jenn P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 25.9 {cholesterol} (#3# recombinant enzyme expressed in hepatic Mc-7777 cells <39>) <39> 25.9 nmol/min/mg cholesterol CHEBI:16113 Y Y ECO:0000006 Pubmed:10685026 PENTACON Added by PENTACON AAP, DGA 4/21/2014 3 2200001851 Jenn P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 27.6 {cholesterol} (#3# recombinant enzyme expressed in baby hamster kidney cells <39>) <39> 27.6 nmol/min/mg cholesterol CHEBI:16113 Y Y ECO:0000006 Pubmed:10685026 PENTACON Added by PENTACON AAP, DGA 4/21/2014 3 2200001852 Jenn P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.00083 {cholesterol} (#3# recombinant enzyme expressed in hepatic Mc-7777 cells <39>) <39> 0.00083 mM cholesterol CHEBI:16113 2.3.1.43 #3# recombinant enzyme expressed in hepatic Mc-7777 cells <39> Y Y ECO:0000006 Pubmed:10685026 BRENDA <39> Ayyobi, A.F.; Lacko, A.G.; Murray, K.; Nair, M.; Li, M.; Molhuizen, H.O.F.; Pritchard, P.H.: Biochemical and compositional analyses of recombinant lecithin:cholesterol acyltransferase (LCAT) obtained from a hepatic source. Biochim. Biophys. Acta (2000) 1484, 1-13. {Pubmed:10685026} AAP, DGA 12/7/2011 1111 2200001853 Jenn P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.00057 {cholesterol} (#3# recombinant enzyme expressed in baby hamster kidney cells <39>) <39> 0.00057 mM cholesterol CHEBI:16113 2.3.1.43 #3# recombinant enzyme expressed in baby hamster kidney cells <39> Y Y ECO:0000006 Pubmed:10685026 BRENDA <39> Ayyobi, A.F.; Lacko, A.G.; Murray, K.; Nair, M.; Li, M.; Molhuizen, H.O.F.; Pritchard, P.H.: Biochemical and compositional analyses of recombinant lecithin:cholesterol acyltransferase (LCAT) obtained from a hepatic source. Biochim. Biophys. Acta (2000) 1484, 1-13. {Pubmed:10685026} AAP, DGA 12/7/2011 1111 2200001854 Jenn P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.0062 {2,3-epoxy-1,3-diphenyl-propane} (#6# 30°C <23>) <23> 0.0062 mM 2,3-epoxy-1,3-diphenyl-propane CHEBI:NONE_148527 3.3.2.10 #6# 30°C <23> Y Y ECO:0000006 Pubmed:10860549 BRENDA <23> Morisseau, C.; Beetham, J.K.; Pinot, F.; Debernard, S.; Newman, J.W.; Hammock, B.D.: Cress and potato soluble epoxide hydrolases: purification, biochemical characterization, and comparison to mammalian enzymes. Arch. Biochem. Biophys. (2000) 378, 321-332. {Pubmed:10860549} (c) AAP, DGA, ASD 12/7/2011 1111 2200001855 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM .0051 {PGE2-ester} 0.0051 mM prostaglandin E2 methyl ester CHEBI:NONE_148528 Y Y ECO:0000006 Pubmed:11422365 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: prostaglandin E2 methyl ester; Pubchem CID 6434107 AAP, ASD 4/21/2014 3 2200001856 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 13480 {PGE2-ester} 13480.0 nmol/min/mg prostaglandin E2 methyl ester CHEBI:NONE_148528 Y Y ECO:0000006 Pubmed:11422365 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: prostaglandin E2 methyl ester; Pubchem CID 6434107 AAP, ASD 4/21/2014 3 2200001857 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM .0456 {NAD+} 0.0456 mM NAD(+) CHEBI:15846 Y Y ECO:0000006 Pubmed:11422365 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001858 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM .0384 {NAD+} 0.0384 mM NAD(+) CHEBI:15846 Y Y ECO:0000006 Pubmed:11422365 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001859 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 19200 {NAD+} 19200.0 nmol/min/mg NAD(+) CHEBI:15846 Y Y ECO:0000006 Pubmed:11422365 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001860 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 21300 {NAD+} 21300.0 nmol/min/mg NAD(+) CHEBI:15846 Y Y ECO:0000006 Pubmed:11422365 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001861 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM .0039 {PGE2} 0.0039 mM prostaglandin E2 CHEBI:15551 Y Y ECO:0000006 Pubmed:11422365 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001862 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM .0043 {PGE2} 0.0043 mM prostaglandin E2 CHEBI:15551 Y Y ECO:0000006 Pubmed:11422365 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001863 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 18600 {PGE2} 18600.0 nmol/min/mg prostaglandin E2 CHEBI:15551 Y Y ECO:0000006 Pubmed:11422365 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001864 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 20450 {PGE2} 20450.0 nmol/min/mg prostaglandin E2 CHEBI:15551 Y Y ECO:0000006 Pubmed:11422365 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001865 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.3-3.8 {alanine-p-nitroanilide} mM alanine-4-nitroanilide CHEBI:NONE_148529 Y Y ECO:0000006 Pubmed:11675384 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: alanine-4-nitroanilide; Pubchem CID 150936 AAP, ASD 4/21/2014 3 2200001866 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.006-0.028 {leukotriene A4} (#4# pH 8.0, wild-type enzyme in comparison to mutant enzymes <36,37>) <36,37> mM leukotriene A4 CHEBI:15651 3.3.2.6 #4# pH 8.0, wild-type enzyme in comparison to mutant enzymes <36,37> Y Y ECO:0000006 Pubmed:11675384 BRENDA <36> Rudberg, P.C.; Tholander, F.; Thunnissen, M.M.; Haeggstrom, J.Z.: Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms. J. Biol. Chem. (2002) 277, 1398-1404. {Pubmed:11675384} AAP, ASD 12/7/2011 1111 2200001867 Christie P35610 6646 SOAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM .0147 {oleoyl-CoA} (mutant C92A/C333A/C345A/C365A/C467A/C516A/C546A) 0.0147 mM oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 Pubmed:11684695 PENTACON Added by PENTACON; PENTACON Notes: Mutant: C92A/C333A/C345A/C365A/C467A/C516A/C546A AAP, ASD 4/21/2014 3 2200001868 Christie P35610 6646 SOAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM .013 {oleoyl-CoA} (mutant C92A/C333A/C345A/C365A/C387A/C467A/C516A/C546A) 0.013 mM oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 Pubmed:11684695 PENTACON Added by PENTACON; PENTACON Notes: Mutant: C92A/C333A/C345A/C365A/C387A/C467A/C516A/C546A AAP, ASD 4/21/2014 3 2200001869 Christie P35610 6646 SOAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM .0118 {oleoyl-CoA} (mutant C92A/C333A/C345A/C365A/C387A/C467A/C516A/C528A/C546A) 0.0118 mM oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 Pubmed:11684695 PENTACON Added by PENTACON; PENTACON Notes: Mutant: C92A/C333A/C345A/C365A/C387A/C467A/C516A/C528A/C546A AAP, ASD 4/21/2014 3 2200001870 Christie P35610 6646 SOAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.0071 {oleoyl-CoA} (#6# wild-type enzyme <36>) <36> 0.0071 mM oleoyl-CoA CHEBI:15534 2.3.1.26 #6# wild-type enzyme <36> Y Y ECO:0000006 Pubmed:11684695 BRENDA <36> Lu, X.; Lin, S.; Chang, C.C.Y.; Chang, T.: Mutant acyl-coenzyme A: cholesterol acyltransferase 1 devoid of cysteine residues remains catalytically active. J. Biol. Chem. (2002) 277, 711-718. {Pubmed:11684695} AAP, ASD 12/7/2011 1111 2200001871 Christie P35610 6646 SOAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.0072 {oleoyl-CoA} (#6# mutant HisACAT1/P64 <37>) <37> 0.0072 mM oleoyl-CoA CHEBI:15534 2.3.1.26 #6# HisACAT1, mutant HisACAT1/P64 <37> Y Y ECO:0000006 Pubmed:11888294 BRENDA <37> Yu, C.; Zhang, Y.; Lu, X.; Chen, J.; Chang, C.C.Y.; Chang, T.: Role of the N-terminal hydrophilic domain of acyl-coenzyme A:cholesterol acyltransferase 1 on the enzymes's quaternary structure and catalytic efficiency. Biochemistry (2002) 41, 3762-3769. {Pubmed:11888294}; PENTACON Notes: Mutant: P64 AAP, ASD 12/7/2011 1111 2200001872 Christie P35610 6646 SOAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.0154 {oleoyl-CoA} (#6# mutant HisACAT1/1-65 <37>) <37> 0.0154 mM oleoyl-CoA CHEBI:15534 2.3.1.26 #6# mutant HisACAT1/1-65 <37> Y Y ECO:0000006 Pubmed:11888294 BRENDA <37> Yu, C.; Zhang, Y.; Lu, X.; Chen, J.; Chang, C.C.Y.; Chang, T.: Role of the N-terminal hydrophilic domain of acyl-coenzyme A:cholesterol acyltransferase 1 on the enzymes's quaternary structure and catalytic efficiency. Biochemistry (2002) 41, 3762-3769. {Pubmed:11888294}; PENTACON Notes: Mutant: delta1-65 AAP, ASD 12/7/2011 1111 2200001873 Christie P35610 6646 SOAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.0072 {oleoyl-CoA} (#6# HisACAT1 <37>) <37> 0.0072 mM oleoyl-CoA CHEBI:15534 2.3.1.26 #6# HisACAT1 <37> Y Y ECO:0000006 Pubmed:11888294 BRENDA <37> Yu, C.; Zhang, Y.; Lu, X.; Chen, J.; Chang, C.C.Y.; Chang, T.: Role of the N-terminal hydrophilic domain of acyl-coenzyme A:cholesterol acyltransferase 1 on the enzymes's quaternary structure and catalytic efficiency. Biochemistry (2002) 41, 3762-3769. {Pubmed:11888294} AAP, ASD 12/7/2011 1111 2200001874 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.3-3.8 {alanine-p-nitroanilide} mM alanine-4-nitroanilide CHEBI:NONE_148529 Y Y ECO:0000006 Pubmed:11917124 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: alanine-4-nitroanilide; Pubchem CID 150936 AAP, ASD 4/21/2014 3 2200001875 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.006-0.028 {leukotriene A4} (#4# pH 8.0, wild-type enzyme in comparison to mutant enzymes <36,37>) <36,37> mM leukotriene A4 CHEBI:15651 3.3.2.6 #4# pH 8.0, wild-type enzyme in comparison to mutant enzymes <36,37> Y Y ECO:0000006 Pubmed:11917124 BRENDA <37> Rudberg, P.C.; Tholander, F.; Thunnissen, M.M.; Samuelsson, B.; Haeggstrom, J.Z.: Leukotriene A4 hydrolase: selective abrogation of leukotriene B4 formation by mutation of aspartic acid 375. Proc. Natl. Acad. Sci. USA (2002) 99, 4215-4220. {Pubmed:11917124} AAP, ASD 12/7/2011 1111 2200001876 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.7 {NAD+} (#4# 37°C, pH 7.5, T11S mutant <35>) <35> 0.7 mM NAD(+) CHEBI:15846 1.1.1.141 #4# 37°C, pH 7.5, T11S mutant <35> Y Y ECO:0000006 Pubmed:12144871 BRENDA <35> Cho, H.; Tai, H.H.: Threonine 11 of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase may interact with NAD(+) during catalysis. Prostaglandins (2002) 66, 505-509. {Pubmed:12144871}; PENTACON Notes: Mutant: T11S AAP, ASD 12/7/2011 1111 2200001877 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0086 {(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate} (#4# 37°C, pH 7.5, T11S mutant <35>) <35> 0.0086 mM prostaglandin E2 CHEBI:15551 1.1.1.141 #4# 37°C, pH 7.5, T11S mutant <35> Y Y ECO:0000006 Pubmed:12144871 BRENDA <35> Cho, H.; Tai, H.H.: Threonine 11 of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase may interact with NAD(+) during catalysis. Prostaglandins (2002) 66, 505-509. {Pubmed:12144871}; PENTACON Notes: Mutant: T11S AAP, ASD 12/7/2011 1111 2200001878 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.03 {NAD+} (#4# 37°C, pH 7.5 <35>) <35> 0.03 mM NAD(+) CHEBI:15846 1.1.1.141 #4# 37°C, pH 7.5 <35> Y Y ECO:0000006 Pubmed:12144871 BRENDA <35> Cho, H.; Tai, H.H.: Threonine 11 of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase may interact with NAD(+) during catalysis. Prostaglandins (2002) 66, 505-509. {Pubmed:12144871} AAP, ASD 12/7/2011 1111 2200001879 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0071 {(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate} (#4# 37°C, pH 7.5 <35>) <35> 0.0071 mM prostaglandin E2 CHEBI:15551 1.1.1.141 #4# 37°C, pH 7.5 <35> Y Y ECO:0000006 Pubmed:12144871 BRENDA <35> Cho, H.; Tai, H.H.: Threonine 11 of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase may interact with NAD(+) during catalysis. Prostaglandins (2002) 66, 505-509. {Pubmed:12144871} AAP, ASD 12/7/2011 1111 2200001880 Jodi P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 338 {threo-10-hydroxy-9-phosphonooxy-octadecanoic acid} 338.0 nmol/min/mg threo-10-hydroxy-9-phosphonooxy-octadecanoic acid CHEBI:NONE_148530 Y Y ECO:0000006 Pubmed:12574510 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: threo-10-hydroxy-9-phosphonooxy-octadecanoic acid AAP, DGA, ASD 4/21/2014 3 2200001881 Jodi P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 57.6 {p-nitrophenyl phosphate} 57.6 nmol/min/mg 4-nitrophenyl phosphate CHEBI:17440 Y Y ECO:0000006 Pubmed:12574510 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001882 Jodi P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.6 {p-nitrophenyl phosphate} <33> 1.6 mM 4-nitrophenyl phosphate CHEBI:17440 3.3.2.10 Y Y ECO:0000006 Pubmed:12574510 BRENDA <33> Newman, J.W.; Morisseau, C.; Harris, T.R.; Hammock, B.D.: The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc. Natl. Acad. Sci. USA (2003) 100, 1558-1563. {Pubmed:12574510} (c); PENTACON Notes: Request ChEBI ID: threo-10-hydroxy-9-phosphonooxy-octadecanoic acid AAP, DGA, ASD 12/7/2011 1111 2200001883 Jodi P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.0209 {threo-10-hydroxy-9-phosphonooxy-octadecanoic acid} <33> 0.0209 mM threo-10-hydroxy-9-phosphonooxy-octadecanoic acid CHEBI:NONE_148530 3.3.2.10 Y Y ECO:0000006 Pubmed:12574510 BRENDA <33> Newman, J.W.; Morisseau, C.; Harris, T.R.; Hammock, B.D.: The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity. Proc. Natl. Acad. Sci. USA (2003) 100, 1558-1563. {Pubmed:12574510} (c) AAP, DGA, ASD 12/7/2011 1111 2200001884 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0039 {(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate} <30> 0.0039 mM prostaglandin E2 CHEBI:15551 1.1.1.141 Y Y ECO:0000033 Pubmed:12664592 BRENDA <30> Tai, H.H.; Ensor, C.M.; Zhou, H.; Yan, F.: Structure and function of human NAD+-linked 15-hydroxyprostaglandin dehydrogenase. Adv. Exp. Med. Biol. (2002) 507, 245-250. {Pubmed:12664592} AAP, ASD 12/7/2011 1111 2200001885 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.046 {NAD+} <30> 0.046 mM NAD(+) CHEBI:15846 1.1.1.141 Y Y ECO:0000033 Pubmed:12664592 BRENDA <30> Tai, H.H.; Ensor, C.M.; Zhou, H.; Yan, F.: Structure and function of human NAD+-linked 15-hydroxyprostaglandin dehydrogenase. Adv. Exp. Med. Biol. (2002) 507, 245-250. {Pubmed:12664592} AAP, ASD 12/7/2011 1111 2200001886 Christie P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# .007 {O2} <40> 0.007 mM dioxygen CHEBI:15379 1.13.11.31 Y Y ECO:0000006 Pubmed:12731864 BRENDA <40> Segraves, E.N.; Holman, T.R.: Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase. Biochemistry (2003) 42, 5236-5243. {Pubmed:12731864} (c) AAP, DGA, AAP-M 12/7/2011 1111 2200001887 Christie P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# .0042 {O2} <34> 0.0042 mM dioxygen CHEBI:15379 1.13.11.33 Y Y ECO:0000006 Pubmed:12731864 BRENDA <34> Segraves, E.N.; Holman, T.R.: Kinetic investigations of the rate-limiting step in human 12- and 15-lipoxygenase. Biochemistry (2003) 42, 5236-5243. {Pubmed:12731864} (c) AAP, DGA, ASD 12/7/2011 1111 2200001888 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #11# 1.6 {glutathione} (#11# human recombinant enzyme <37>) <37> 2700.0 nmol/min/mg glutathione CHEBI:16856 Y Y ECO:0000033 Pubmed:12895593 PENTACON Added by PENTACON; PENTACON Notes: human recombinant enzyme AAP, DGA, ASD 4/21/2014 3 2200001889 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1300 {leukotriene A4} (#11# human recombinant enzyme <37>) <37> 1300.0 nmol/min/mg leukotriene A4 CHEBI:15651 Y Y ECO:0000033 Pubmed:12895593 PENTACON Added by PENTACON; PENTACON Notes: human recombinant enzyme AAP, DGA, ASD 4/21/2014 3 2200001890 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/KM #11# 1.6 {glutathione} (#11# human recombinant enzyme <37>) <37> 1.6 mM glutathione CHEBI:16856 4.4.1.20 #11# human recombinant enzyme <37> Y Y ECO:0000033 Pubmed:12895593 BRENDA <37> Lam, B.K.: Leukotriene C4 synthase. Prostaglandins Leukot. Essent. Fatty Acids (2003) 69, 111-116. {Pubmed:} AAP, DGA, ASD 12/7/2011 1111 2200001891 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/KM #11# 0.0036 {leukotriene A4} (#11# human recombinant enzyme <37>) <37> 0.0036 mM leukotriene A4 CHEBI:15651 4.4.1.20 #11# human recombinant enzyme <37> Y Y ECO:0000033 Pubmed:12895593 BRENDA <37> Lam, B.K.: Leukotriene C4 synthase. Prostaglandins Leukot. Essent. Fatty Acids (2003) 69, 111-116. {Pubmed:} AAP, DGA, ASD 12/7/2011 1111 2200001892 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.11 {leukotriene A5} (#3# pH 6.5, 30°C <15>) 0.11 mM leukotriene A5 CHEBI:NONE_148531 Y Y ECO:0000006 Pubmed:1312812 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: Leukotriene A5; pH 6.5, 30°C AAP, DGA, ASD 4/21/2014 3 2200001893 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.41 {leukotriene A5} (#3# pH 6.5, 30°C <15>) 0.41 nmol/min/mg leukotriene A5 CHEBI:NONE_148531 Y Y ECO:0000006 Pubmed:1312812 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: Leukotriene A5; pH 6.5, 30°C AAP, DGA, ASD 4/21/2014 3 2200001894 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.04 {leukotriene methyl ester} (#3# pH 6.5, 30°C <15>; #1# 22°C, pH 7.6 <23>) <15,23> 0.04 nmol/min/mg leukotriene methyl ester CHEBI:NONE_148532 Y Y ECO:0000006 Pubmed:1312812 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: 5S-€‹trans-€‹5,€‹6-€‹oxido-€‹7E,€‹9E,€‹11Z,€‹14Z-€‹eicosatetraenoic acid,€‹ methyl ester AAP, DGA, ASD 4/21/2014 3 2200001895 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.56 {leukotriene A4} (#3# pH 6.5, 30°C <15>) <15> 0.56 nmol/min/mg leukotriene A4 CHEBI:15651 Y Y ECO:0000006 Pubmed:1312812 PENTACON Added by PENTACON; PENTACON Notes: pH 6.5, 30°C AAP, DGA, ASD 4/21/2014 3 2200001896 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/KM #1,3# 0.015 {leukotriene methyl ester} (#3# pH 6.5, 30°C <15>; #1# 22°C, pH 7.6 <23>) <15,23> 0.015 mM leukotriene methyl ester CHEBI:NONE_148532 4.4.1.20 #3# pH 6.5, 30°C <15>; #1# 22°C, pH 7.6 <23> Y Y ECO:0000006 Pubmed:1312812 BRENDA <15> Soderstrom, M.; Mannervik, B.; Garkov, V.; Hammarstrom, S.: On the nature of leukotriene C4 synthase in human platelets. Arch. Biochem. Biophys. (1992) 294, 70-74. {Pubmed:1312812} (c); PENTACON Notes: Request ChEBI ID: 5S-€‹trans-€‹5,€‹6-€‹oxido-€‹7E,€‹9E,€‹11Z,€‹14Z-€‹eicosatetraenoic acid,€‹ methyl ester AAP, DGA, ASD 12/7/2011 1111 2200001897 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.007 {leukotriene A4} (#3# pH 6.5, 30°C <15>) <15> 0.007 mM leukotriene A4 CHEBI:15651 4.4.1.20 #3# pH 6.5, 30°C <15> Y Y ECO:0000006 Pubmed:1312812 BRENDA <15> Soderstrom, M.; Mannervik, B.; Garkov, V.; Hammarstrom, S.: On the nature of leukotriene C4 synthase in human platelets. Arch. Biochem. Biophys. (1992) 294, 70-74. {Pubmed:1312812} (c) AAP, DGA, ASD 12/7/2011 1111 2200001898 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/KM 1.83 {glutathione} <21> 1.83 mM glutathione CHEBI:16856 Y Y ECO:0000006 Pubmed:1425677 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001899 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0166 {leukotriene A4} <21> 0.0166 mM leukotriene A4 CHEBI:15651 4.4.1.20 Y Y ECO:0000006 Pubmed:1425677 BRENDA <21> Nicholson, D.W.; Klemba, M.W.; Rasper, D.M.; Metters, K.M.; Zamboni, R.J.: Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells. Eur. J. Biochem. (1992) 209, 725-734. {Pubmed:1425677} (c) AAP, DGA, ASD 12/7/2011 1111 2200001900 Jenn P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0279-0.9145 {NAD+} (#4# 37°C, pH 7.5 <32>; #4# 37°C, pH 7.5, various mutants <33>) <32,33> mM NAD(+) CHEBI:15846 1.1.1.141 #4# 37°C, pH 7.5 <32>; #4# 37°C, pH 7.5, various mutants <33> Y Y ECO:0000006 Pubmed:14592457 BRENDA <32> Cho, H.; Oliveira, M.A.; Tai, H.H.: Critical residues for the coenzyme specificity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2003) 419, 139-146. {Pubmed:14592457}; PENTACON Notes: various mutants AAP, ASD 12/7/2011 1111 2200001901 Jenn P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.0053-1.068 {prostaglandin E2} (#4# 37°C, pH 7.5, various mutants <32>) <32> mM prostaglandin E2 CHEBI:15551 1.1.1.141 #4# 37°C, pH 7.5, various mutants <32> Y Y ECO:0000006 Pubmed:14592457 BRENDA <32> Cho, H.; Oliveira, M.A.; Tai, H.H.: Critical residues for the coenzyme specificity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2003) 419, 139-146. {Pubmed:14592457}; PENTACON Notes: various mutants AAP, ASD 12/7/2011 1111 2200001902 Jenn P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0315 {NAD+} (#4# 37°C, pH 7.5 <32>; #4# 37°C, pH 7.5 <33>) <32,33> 0.032 mM NAD(+) CHEBI:15846 1.1.1.141 #4# 37°C, pH 7.5 <32>; #4# 37°C, pH 7.5 <33> Y Y ECO:0000006 Pubmed:14592457 BRENDA <32> Cho, H.; Oliveira, M.A.; Tai, H.H.: Critical residues for the coenzyme specificity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2003) 419, 139-146. {Pubmed:14592457} AAP, ASD 12/7/2011 1111 2200001903 Jenn P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0063 {(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate} (#4# 37°C, pH 7.5 <32>) <32> 0.0063 mM prostaglandin E2 CHEBI:15551 1.1.1.141 #4# 37°C, pH 7.5 <32> Y Y ECO:0000006 Pubmed:14592457 BRENDA <32> Cho, H.; Oliveira, M.A.; Tai, H.H.: Critical residues for the coenzyme specificity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2003) 419, 139-146. {Pubmed:14592457} AAP, ASD 12/7/2011 1111 2200001904 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0117 {prostaglandin E2} <22> 0.0117 mM prostaglandin E2 CHEBI:15551 1.1.1.141 Y Y ECO:0000006 Pubmed:1508959 BRENDA <22> Mibe, M.; Nagai, K.; Oshige, T.; Mori, N.: Endogenous inhibitors of human placental prostaglandin dehydrogenase. Prostaglandins Leukot. Essent. Fatty Acids (1992) 46, 241-245. {Pubmed:1508959} AAP, ASD 12/7/2011 1111 2200001905 Jodi Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/IC50 0.050 {diethylcarbamazine} 0.05 mM diethylcarbamazine CHEBI:4527 Y Y ECO:0000006 Pubmed:1517222 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001906 Jodi Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/IC50 0.020 {N-ethylmaleimide} 0.02 mM N-ethylmaleimide CHEBI:44485 Y Y ECO:0000006 Pubmed:1517222 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200001907 Jodi Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 1.2 {glutathione} (#3# pH 7.4, 25°C <10>) <10> 1.2 mM glutathione CHEBI:16856 4.4.1.20 #3# pH 7.4, 25°C <10> Y Y ECO:0000006 Pubmed:1517222 BRENDA <10> Nicholson, D.W.; Ali, A.; Klemba, M.W.; Munday, N.A.; Zamboni, R.J.; Ford-Hutchinson, A.W.: Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells. J. Biol. Chem. (1992) 267, 17849-17857. {Pubmed:1517222} (c) AAP, DGA, ASD 12/7/2011 1111 2200001908 Jodi Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0056 {leukotriene A4} (#3# pH 7.4, 25°C <10>) <10> 0.0056 mM leukotriene A4 CHEBI:15651 4.4.1.20 #3# pH 7.4, 25°C <10> Y Y ECO:0000006 Pubmed:1517222 BRENDA <10> Nicholson, D.W.; Ali, A.; Klemba, M.W.; Munday, N.A.; Zamboni, R.J.; Ford-Hutchinson, A.W.: Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells. J. Biol. Chem. (1992) 267, 17849-17857. {Pubmed:1517222} (c) AAP, DGA, ASD 12/7/2011 1111 2200001909 Jodi P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 27.2 {1,2-bis[4-(1-pyreno)butanoyl]-sn-glycero-3-phosphocholine} 27.2 uM/min/ug 1,2-bis[4-(1-pyreno)butanoyl]-sn-glycero-3-phosphocholine CHEBI:NONE_148533 Y Y ECO:0000006 Pubmed:15249036 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: 1,2-bis[4-(1-pyreno)butanoyl]-sn-glycero-3-phosphocholine AAP, DGA 4/21/2014 3 2200001910 Jodi P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 10.0 {Phosphatidylcholine} 10.0 uM/min/ug phosphatidylcholine CHEBI:49183 Y Y ECO:0000006 Pubmed:15249036 PENTACON Added by PENTACON AAP, DGA 4/21/2014 3 2200001911 Jodi P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM #13# 0.00056 {1,2-bis[4-(1-pyreno)butanoyl]-sn-glycero-3-phosphocholine} (#13# fluorescent assay, pH 7.4, 25°C, recombinant enzyme <61>) <61> 0.00056 mM 1,2-bis[4-(1-pyreno)butanoyl]-sn-glycero-3-phosphocholine CHEBI:NONE_148533 2.3.1.43 #13# fluorescent assay, pH 7.4, 25°C, recombinant enzyme <61> Y Y ECO:0000006 Pubmed:15249036 BRENDA <61> Lane, S.B.; Tchedre, K.T.; Nair, M.P.; Thigpen, A.E.; Lacko, A.G.: Characterization of lecithin:cholesterol acyltransferase expressed in a human lung cell line. Protein Expr. Purif. (2004) 36, 157-164. {Pubmed:15249036}; PENTACON Notes: Request ChEBI ID: 1,2-bis[4-(1-pyreno)butanoyl]-sn-glycero-3-phosphocholine AAP, DGA 12/7/2011 1111 2200001912 Jodi P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM #13# 0.0006 {Phosphatidylcholine} (#13# radioassay, pH 7.4, 37°C, recombinant enzyme <61>) <61> 0.0006 mM phosphatidylcholine CHEBI:49183 2.3.1.43 #13# radioassay, pH 7.4, 37°C, recombinant enzyme <61> Y Y ECO:0000006 Pubmed:15249036 BRENDA <61> Lane, S.B.; Tchedre, K.T.; Nair, M.P.; Thigpen, A.E.; Lacko, A.G.: Characterization of lecithin:cholesterol acyltransferase expressed in a human lung cell line. Protein Expr. Purif. (2004) 36, 157-164. {Pubmed:15249036} AAP, DGA 12/7/2011 1111 2200001913 Jodi Q05469 3991 LIPE Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 70 {vinyl propionate} (#2# 37°C, pH 8.0 <16>) <16> 70.0 mM vinyl propionate CHEBI:NONE_148534 3.1.1.79 #2# 37°C, pH 8.0 <16> Y Y ECO:0000006 Pubmed:15260473 BRENDA <16> Ben Ali, Y.; Chahinian, H.; Petry, S.; Muller, G.; Carriere, F.; Verger, R.; Abousalham, A.: Might the kinetic behavior of hormone-sensitive lipase reflect the absence of the lid domain?. Biochemistry (2004) 43, 9298-9306. {Pubmed:15260473}; PENTACON Notes: Request ChEBI ID: vinyl propionate; Pubchem ID: CID 7750 AAP, DGA, ASD 12/7/2011 1111 2200001914 Jodi Q05469 3991 LIPE Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 10 {vinyl butyrate} (#2# 37°C, pH 8.0 <16>) <16> 10.0 mM vinyl butyrate CHEBI:NONE_148535 3.1.1.79 #2# 37°C, pH 8.0 <16> Y Y ECO:0000006 Pubmed:15260473 BRENDA <16> Ben Ali, Y.; Chahinian, H.; Petry, S.; Muller, G.; Carriere, F.; Verger, R.; Abousalham, A.: Might the kinetic behavior of hormone-sensitive lipase reflect the absence of the lid domain?. Biochemistry (2004) 43, 9298-9306. {Pubmed:15260473}; PENTACON Notes: Request ChEBI ID: vinyl butyrate; Pubchem ID: CID 31247 AAP, DGA, ASD 12/7/2011 1111 2200001915 Jodi Q05469 3991 LIPE Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 15 {tripropionyl glycerol} (#2# 37°C, pH 8.0 <16>) <16> 15.0 mM tripropionyl glycerol CHEBI:NONE_148536 3.1.1.79 #2# 37°C, pH 8.0 <16> Y Y ECO:0000006 Pubmed:15260473 BRENDA <16> Ben Ali, Y.; Chahinian, H.; Petry, S.; Muller, G.; Carriere, F.; Verger, R.; Abousalham, A.: Might the kinetic behavior of hormone-sensitive lipase reflect the absence of the lid domain?. Biochemistry (2004) 43, 9298-9306. {Pubmed:15260473}; PENTACON Notes: Request ChEBI ID: tripropionyl glycerol; Pubchem ID: CID 8763 AAP, DGA, ASD 12/7/2011 1111 2200001916 Jodi Q05469 3991 LIPE Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.4 {tributanoyl glycerol} (#2# 37°C, pH 8.0 <16>) <16> 0.4 mM tributanoyl glycerol CHEBI:NONE_148537 3.1.1.79 #2# 37°C, pH 8.0 <16> Y Y ECO:0000006 Pubmed:15260473 BRENDA <16> Ben Ali, Y.; Chahinian, H.; Petry, S.; Muller, G.; Carriere, F.; Verger, R.; Abousalham, A.: Might the kinetic behavior of hormone-sensitive lipase reflect the absence of the lid domain?. Biochemistry (2004) 43, 9298-9306. {Pubmed:15260473}; PENTACON Notes: Request ChEBI ID: tributanoyl glycerol AAP, DGA, ASD 12/7/2011 1111 2200001917 Jodi Q05469 3991 LIPE Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 170 {vinyl acetate} (#2# 37°C, pH 8.0 <16>) <16> 170.0 mM vinyl acetate CHEBI:46916 3.1.1.79 #2# 37°C, pH 8.0 <16> Y Y ECO:0000006 Pubmed:15260473 BRENDA <16> Ben Ali, Y.; Chahinian, H.; Petry, S.; Muller, G.; Carriere, F.; Verger, R.; Abousalham, A.: Might the kinetic behavior of hormone-sensitive lipase reflect the absence of the lid domain?. Biochemistry (2004) 43, 9298-9306. {Pubmed:15260473} AAP, DGA, ASD 12/7/2011 1111 2200001918 Jodi P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 130 {proline-4-nitroanilide} 130.0 nmol/min/mg proline-4-nitroanilide CHEBI:NONE_148538 Y Y ECO:0000006 Pubmed:1536866 PENTACON Added by PENTACON; PENTACON Notes: pH 7.6, 22°C, 100 mM NaCl; Request ChEBI ID: proline-4-nitroanilide AAP, ASD 4/21/2014 3 2200001919 Jodi P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 30 {lysine-4-nitroanilide} 30.0 nmol/min/mg lysine-4-nitroanilide CHEBI:NONE_148539 Y Y ECO:0000006 Pubmed:1536866 PENTACON Added by PENTACON; PENTACON Notes: pH 7.6, 22°C, 100 mM NaCl; Request ChEBI ID: lysine-4-nitroanilide AAP, ASD 4/21/2014 3 2200001920 Jodi P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 130 {leucine-4-nitroanilide} 130.0 nmol/min/mg leucine-4-nitroanilide CHEBI:NONE_148525 Y Y ECO:0000006 Pubmed:1536866 PENTACON Added by PENTACON; PENTACON Notes: pH 7.6, 22°C, 100 mM NaCl; Request ChEBI ID: leucine-4-nitroanilide: CID 121895 AAP, ASD 4/21/2014 3 2200001921 Jodi P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 140 {arginine-4-nitroanilide} 140.0 nmol/min/mg arginine-4-nitroanilide CHEBI:NONE_148540 Y Y ECO:0000006 Pubmed:1536866 PENTACON Added by PENTACON; PENTACON Notes: pH 7.6, 22°C, 100 mM NaCl; Request ChEBI ID: arginine-4-nitroanilide AAP, ASD 4/21/2014 3 2200001922 Jodi P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 530 {alanine-4-nitroanilide} 530.0 nmol/min/mg alanine-4-nitroanilide CHEBI:NONE_148529 Y Y ECO:0000006 Pubmed:1536866 PENTACON Added by PENTACON; PENTACON Notes: pH 7.6, 22°C, 100 mM NaCl; Request ChEBI ID: alanine-4-nitroanilide; Pubchem ID: CID 150936 AAP, ASD 4/21/2014 3 2200001923 Jodi P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.1 {lysine-4-nitroanilide} (#4# pH 7.6, 22°C <17>) <17> 0.1 mM lysine-4-nitroanilide CHEBI:NONE_148539 3.3.2.6 #4# pH 7.6, 22°C <17> Y Y ECO:0000006 Pubmed:1536866 BRENDA <17> Wetterholm, A.; Haeggstrom, J.Z.: Leukotriene A4 hydrolase: an anion activated peptidase. Biochim. Biophys. Acta (1992) 1123, 275-281. {Pubmed:1536866}; PENTACON Notes: Request ChEBI ID: lysine-4-nitroanilide AAP, ASD 12/7/2011 1111 2200001924 Jodi P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.1 {proline-4-nitroanilide} (#4# pH 7.6, 22°C <17>) <17> 0.1 mM proline-4-nitroanilide CHEBI:NONE_148538 3.3.2.6 #4# pH 7.6, 22°C <17> Y Y ECO:0000006 Pubmed:1536866 BRENDA <17> Wetterholm, A.; Haeggstrom, J.Z.: Leukotriene A4 hydrolase: an anion activated peptidase. Biochim. Biophys. Acta (1992) 1123, 275-281. {Pubmed:1536866}; PENTACON Notes: 100 mM NaCl; Request ChEBI ID: proline-4-nitroanilide AAP, ASD 12/7/2011 1111 2200001925 Jodi P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.3 {leucine-4-nitroanilide} (#4# pH 7.6, 22°C <17>) <17> 0.3 mM leucine-4-nitroanilide CHEBI:NONE_148525 3.3.2.6 #4# pH 7.6, 22°C <17> Y Y ECO:0000006 Pubmed:1536866 BRENDA <17> Wetterholm, A.; Haeggstrom, J.Z.: Leukotriene A4 hydrolase: an anion activated peptidase. Biochim. Biophys. Acta (1992) 1123, 275-281. {Pubmed:1536866}; PENTACON Notes: 100 mM NaCl; Request ChEBI ID: leucine-4-nitroanilide AAP, ASD 12/7/2011 1111 2200001926 Jodi P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.2 {arginine-4-nitroanilide} (#4# pH 7.6, 22°C <17>) <17> 0.2 mM arginine-4-nitroanilide CHEBI:NONE_148540 3.3.2.6 #4# pH 7.6, 22°C <17> Y Y ECO:0000006 Pubmed:1536866 BRENDA <17> Wetterholm, A.; Haeggstrom, J.Z.: Leukotriene A4 hydrolase: an anion activated peptidase. Biochim. Biophys. Acta (1992) 1123, 275-281. {Pubmed:1536866}; PENTACON Notes: 100 mM NaCl; Request ChEBI ID: arginine-4-nitroanilide AAP, ASD 12/7/2011 1111 2200001927 Jodi P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.5 {alanine-4-nitroanilide} (#4# pH 7.6, 22°C <17>) <17> 0.5 mM alanine-4-nitroanilide CHEBI:NONE_148529 3.3.2.6 #4# pH 7.6, 22°C <17> Y Y ECO:0000006 Pubmed:1536866 BRENDA <17> Wetterholm, A.; Haeggstrom, J.Z.: Leukotriene A4 hydrolase: an anion activated peptidase. Biochim. Biophys. Acta (1992) 1123, 275-281. {Pubmed:1536866}; PENTACON Notes: 100 mM NaCl; Request ChEBI ID: alanine-4-nitroanilide; Pubchem ID: CID 150936 AAP, ASD 12/7/2011 1111 2200001928 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.022 {NAD+} (#4# recombinant enzyme expressed in E. coli <26>; #4# 37°C, pH 7.5, V186K mutant <33>) <26,33> 0.022 mM NAD(+) CHEBI:15846 1.1.1.141 #4# recombinant enzyme expressed in E. coli <26>; #4# 37°C, pH 7.5, V186K mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: V186K AAP, ASD 12/7/2011 1111 2200001929 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0035 {(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate} (#4# 37°C, pH 7.5, V186K mutant <33>) <33> 0.0035 mM prostaglandin E2 CHEBI:15551 1.1.1.141 #4# 37°C, pH 7.5, V186K mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: V186K AAP, ASD 12/7/2011 1111 2200001930 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.27 {NAD+} (#4# 37°C, pH 7.5, V186I mutant <33>) <33> 0.27 mM NAD(+) CHEBI:15846 1.1.1.141 #4# 37°C, pH 7.5, V186I mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: V186I AAP, ASD 12/7/2011 1111 2200001931 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.022 {(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate} (#4# 37°C, pH 7.5, V186I mutant <33>) <33> 0.022 mM prostaglandin E2 CHEBI:15551 1.1.1.141 #4# 37°C, pH 7.5, V186I mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: V186I AAP, ASD 12/7/2011 1111 2200001932 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.024 {NAD+} (#4# 37°C, pH 7.5, V186A mutant <33>) <33> 0.024 mM NAD(+) CHEBI:15846 1.1.1.141 #4# 37°C, pH 7.5, V186A mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: V186A AAP, ASD 12/7/2011 1111 2200001933 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.032 {NAD+} (#4# 37°C, pH 7.5 <32>; #4# 37°C, pH 7.5, N91D mutant <33>) <32,33> 0.032 mM NAD(+) CHEBI:15846 1.1.1.141 #4# 37°C, pH 7.5 <32>; #4# 37°C, pH 7.5, N91D mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: N91D AAP, ASD 12/7/2011 1111 2200001934 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0026 {(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate} (#4# 37°C, pH 7.5, N91D mutant <33>) <33> 0.0026 mM prostaglandin E2 CHEBI:15551 1.1.1.141 #4# 37°C, pH 7.5, N91D mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: N91D AAP, ASD 12/7/2011 1111 2200001935 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.72 {NAD+} (#4# 37°C, pH 7.5, N91A mutant <33>) <33> 0.72 mM NAD(+) CHEBI:15846 1.1.1.141 #4# 37°C, pH 7.5, N91A mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: N91A AAP, ASD 12/7/2011 1111 2200001936 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.006 {(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate} (#4# 37°C, pH 7.5, N91A mutant <33>) <33> 0.006 mM prostaglandin E2 CHEBI:15551 1.1.1.141 #4# 37°C, pH 7.5, N91A mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: N91A AAP, ASD 12/7/2011 1111 2200001937 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.098 {NAD+} (#4# 37°C, pH 7.5, I17V mutant <33>) <33> 0.098 mM NAD(+) CHEBI:15846 1.1.1.141 #4# 37°C, pH 7.5, I17V mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: I17V AAP, ASD 12/7/2011 1111 2200001938 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.011 {(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate} (#4# 37°C, pH 7.5, I17V mutant <33>) <33> 0.011 mM prostaglandin E2 CHEBI:15551 1.1.1.141 #4# 37°C, pH 7.5, I17V mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: I17V AAP, ASD 12/7/2011 1111 2200001939 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.059 {NAD+} (#4# 37°C, pH 7.5, I17L mutant <33>) <33> 0.059 mM NAD(+) CHEBI:15846 1.1.1.141 #4# 37°C, pH 7.5, I17L mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: I17L AAP, ASD 12/7/2011 1111 2200001940 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0012 {(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate} (#4# 37°C, pH 7.5, I17L mutant <33>) <33> 0.0012 mM prostaglandin E2 CHEBI:15551 1.1.1.141 #4# 37°C, pH 7.5, I17L mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: I17L AAP, ASD 12/7/2011 1111 2200001941 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.55 {NAD+} (#4# 37°C, pH 7.5, I17A mutant <33>) <33> 0.55 mM NAD(+) CHEBI:15846 1.1.1.141 #4# 37°C, pH 7.5, I17A mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: I17A AAP, ASD 12/7/2011 1111 2200001942 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.011 {(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate} (#4# 37°C, pH 7.5, I17A mutant <33>) <33> 0.011 mM prostaglandin E2 CHEBI:15551 1.1.1.141 #4# 37°C, pH 7.5, I17A mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601}; PENTACON Notes: Mutant: I17A AAP, ASD 12/7/2011 1111 2200001943 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.038 {NAD+} (#4# 37°C, pH 7.5 <33>) <33> 0.038 mM NAD(+) CHEBI:15846 1.1.1.141 #4# 37°C, pH 7.5 <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601} AAP, ASD 12/7/2011 1111 2200001944 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0034 {(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate} (#4# 37°C, pH 7.5 <33>) <33> 0.0034 mM prostaglandin E2 CHEBI:15551 1.1.1.141 #4# 37°C, pH 7.5 <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601} AAP, ASD 12/7/2011 1111 2200001945 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0045 {(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-5,13-dienoate} (#4# 37°C, pH 7.5, V186A mutant <33>) <33> 0.0045 mM prostaglandin E2 CHEBI:15551 1.1.1.141 #4# 37°C, pH 7.5, V186A mutant <33> Y Y ECO:0000006 Pubmed:15581601 BRENDA <33> Cho, H.; Hamza, A.; Zhan, C.G.; Tai, H.H.: Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch. Biochem. Biophys. (2005) 433, 447-453. {Pubmed:15581601} AAP, ASD 12/7/2011 1111 2200001946 Chandra Q9UJ14 2686 GGT7 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.8 {5-L-Glutamyl-4-nitroanilide} <84> 1.8 mM gamma-L-Glutamyl-p-nitroanilide CHEBI:NONE_148541 glycylglycine CHEBI:17201 2.3.2.2 Y Y ECO:0000006 Pubmed:15943911 BRENDA <84> Sener, A.; Yardimci, T.: Activity determination, kinetic analyses and isoenzyme identification of gamma glutamyltransferase in human neutrophils. J. Biochem. Mol. Biol. (2005) 38, 343-349. {Pubmed:15943911} (c); PENTACON Notes: Request ChEBI ID: gamma-L-Glutamyl-p-nitroanilide: CID 16219428; GGT 4 is an alias for GGT7 AAP 12/7/2011 1111 2200001947 Chandra Q9UJ14 2686 GGT7 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 16.9 {Glycylglycine} <84> 16.9 mM glycylglycine CHEBI:17201 gamma-L-Glutamyl-p-nitroanilide CHEBI:NONE_148541 2.3.2.2 Y Y ECO:0000006 Pubmed:15943911 BRENDA <84> Sener, A.; Yardimci, T.: Activity determination, kinetic analyses and isoenzyme identification of gamma glutamyltransferase in human neutrophils. J. Biochem. Mol. Biol. (2005) 38, 343-349. {Pubmed:15943911} (c); PENTACON Notes: Request ChEBI ID: gamma-L-Glutamyl-p-nitroanilide: CID 16219428; GGT 4 is an alias for GGT7 AAP 12/7/2011 1111 2200001948 Jenn Q7L5N7 54947 LPCAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2.83 {acetyl-CoA} (#2# total membrane fractions of mesangial cells <27>) <27> 2.83 nmol/min/mg acetyl-CoA CHEBI:15351 Y Y ECO:0000006 Pubmed:16258193 PENTACON Added by PENTACON; PENTACON Notes: Acetyl-CoA concentration range: 0.025-0.8 mM AAP 4/21/2014 3 2200001949 Jenn Q7L5N7 54947 LPCAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2.69 {acetyl-CoA} (#2# total membrane fractions of mesangial cells <27>) <27> 2.69 nmol/min/mg acetyl-CoA CHEBI:15351 Y Y ECO:0000006 Pubmed:16258193 PENTACON Added by PENTACON; PENTACON Notes: Acetyl-CoA concentration 0.2 mM AAP 4/21/2014 3 2200001950 Jenn Q7L5N7 54947 LPCAT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.00921 {acetyl-CoA} (#2# total membrane fractions of mesangial cells <27>) <27> 0.00921 mM acetyl-CoA CHEBI:15351 2.3.1.67 #2# total membrane fractions of mesangial cells <27> Y Y ECO:0000006 Pubmed:16258193 BRENDA <27> Fragopoulou, E.; Iatrou, C.; Demopoulos, C.A.: Characterization of acetyl-CoA:lyso-PAF acetyltransferase of human mesangial cells. Mediators Inflamm. (2005) 2005, 263-272. {Pubmed:16258193}; PENTACON Notes: Acetyl-CoA concentration range: 0.025-0.8 mM AAP 12/7/2011 1111 2200001951 Jenn Q7L5N7 54947 LPCAT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0712 {acetyl-CoA} (#2# total membrane fractions of mesangial cells <27>) <27> 0.0712 mM acetyl-CoA CHEBI:15351 2.3.1.67 #2# total membrane fractions of mesangial cells <27> Y Y ECO:0000006 Pubmed:16258193 BRENDA <27> Fragopoulou, E.; Iatrou, C.; Demopoulos, C.A.: Characterization of acetyl-CoA:lyso-PAF acetyltransferase of human mesangial cells. Mediators Inflamm. (2005) 2005, 263-272. {Pubmed:16258193}; PENTACON Notes: Acetyl-CoA concentration 0.2 mM AAP 12/7/2011 1111 2200001952 Jenn Q05469 3991 LIPE Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 70 {vinyl propionate} <31> 70.0 mM vinyl propionate CHEBI:NONE_148534 3.1.1.79 Y Y ECO:0000006 Pubmed:16325466 BRENDA <31> Chahinian, H.; Ali, Y.B.; Abousalham, A.; Petry, S.; Mandrich, L.; Manco, G.; Canaan, S.; Sarda, L.: Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterases. Biochim. Biophys. Acta (2005) 1738, 29-36. {Pubmed:16325466} (c); PENTACON Notes: Request ChEBI ID: vinyl propionate; Pubchem:CID 7750 AAP, DGA, ASD 12/7/2011 1111 2200001953 Jenn Q05469 3991 LIPE Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 3 {vinyl laurate} <31> 3.0 mM vinyl laurate CHEBI:NONE_148542 3.1.1.79 Y Y ECO:0000006 Pubmed:16325466 BRENDA <31> Chahinian, H.; Ali, Y.B.; Abousalham, A.; Petry, S.; Mandrich, L.; Manco, G.; Canaan, S.; Sarda, L.: Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterases. Biochim. Biophys. Acta (2005) 1738, 29-36. {Pubmed:16325466} (c); PENTACON Notes: Request ChEBI ID: vinyl laurate; Pubchem ID: CID 75069 AAP, DGA, ASD 12/7/2011 1111 2200001954 Jenn Q05469 3991 LIPE Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 11 {vinyl butyrate} <31> 11.0 mM vinyl butyrate CHEBI:NONE_148535 3.1.1.79 Y Y ECO:0000006 Pubmed:16325466 BRENDA <31> Chahinian, H.; Ali, Y.B.; Abousalham, A.; Petry, S.; Mandrich, L.; Manco, G.; Canaan, S.; Sarda, L.: Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterases. Biochim. Biophys. Acta (2005) 1738, 29-36. {Pubmed:16325466} (c); PENTACON Notes: Request Chebi ID: vinyl butyrate; Pubchem ID:CID 31247 AAP, DGA, ASD 12/7/2011 1111 2200001955 Jenn Q05469 3991 LIPE Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 15 {tripropionin} <31> 15.0 mM tripropionin CHEBI:NONE_148543 3.1.1.79 Y Y ECO:0000006 Pubmed:16325466 BRENDA <31> Chahinian, H.; Ali, Y.B.; Abousalham, A.; Petry, S.; Mandrich, L.; Manco, G.; Canaan, S.; Sarda, L.: Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterases. Biochim. Biophys. Acta (2005) 1738, 29-36. {Pubmed:16325466} (c); PENTACON Notes: Request Chebi ID: tripropionin; Pubchem ID: CID 8763 AAP, DGA, ASD 12/7/2011 1111 2200001956 Jenn Q05469 3991 LIPE Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.4 {tributyrin} <31> 0.4 mM EC 3.1.1.3 (triacylglycerol lipase) inhibitor CHEBI:65001 3.1.1.79 Y Y ECO:0000006 Pubmed:16325466 BRENDA <31> Chahinian, H.; Ali, Y.B.; Abousalham, A.; Petry, S.; Mandrich, L.; Manco, G.; Canaan, S.; Sarda, L.: Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterases. Biochim. Biophys. Acta (2005) 1738, 29-36. {Pubmed:16325466} (c) AAP, DGA, ASD 12/7/2011 1111 2200001957 Jenn Q05469 3991 LIPE Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 170 {vinyl acetate} <31> 170.0 mM vinyl acetate CHEBI:46916 3.1.1.79 Y Y ECO:0000006 Pubmed:16325466 BRENDA <31> Chahinian, H.; Ali, Y.B.; Abousalham, A.; Petry, S.; Mandrich, L.; Manco, G.; Canaan, S.; Sarda, L.: Substrate specificity and kinetic properties of enzymes belonging to the hormone-sensitive lipase family: comparison with non-lipolytic and lipolytic carboxylesterases. Biochim. Biophys. Acta (2005) 1738, 29-36. {Pubmed:16325466} (c) AAP, DGA, ASD 12/7/2011 1111 2200001958 Christie P35610 6646 SOAT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 21.8 {oleoyl-CoA} 21.8 nmol/min/mg oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 Pubmed:16820149 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200001959 Christie P35610 6646 SOAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.00462 {oleoyl-CoA} <69> 0.00462 mM oleoyl-CoA CHEBI:15534 2.3.1.26 Y Y ECO:0000006 Pubmed:16820149 BRENDA <69> Ikenoya, M.; Yoshinaka, Y.; Kobayashi, H.; Kawamine, K.; Shibuya, K.; Sato, F.; Sawanobori, K.; Watanabe, T.; Miyazaki, A.: A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels. Atherosclerosis (2007) 191, 290-297. {Pubmed:16820149} AAP, ASD 12/7/2011 1111 2200001960 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 224 {Decanoyl-CoA} <107> 224.0 nmol/min/mg decanoyl-CoA CHEBI:28493 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001961 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 212 {Decanoyl-CoA} <107> 212.0 nmol/min/mg decanoyl-CoA CHEBI:28493 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001962 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 700 {Dodecanoyl-CoA} <107> 700.0 nmol/min/mg lauroyl-CoA CHEBI:15521 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001963 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 681 {Dodecanoyl-CoA} <107> 681.0 nmol/min/mg lauroyl-CoA CHEBI:15521 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001964 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 520 {eicosanoyl-CoA} <107> 520.0 nmol/min/mg icosanoyl-CoA CHEBI:15527 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001965 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 408 {eicosanoyl-CoA} <107> 408.0 nmol/min/mg icosanoyl-CoA CHEBI:15527 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001966 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 691 {hexadecanoyl-CoA} <107> 691.0 nmol/min/mg hexadecanoyl-CoA CHEBI:24544 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001967 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 656 {hexadecanoyl-CoA} <60,107> 656.0 nmol/min/mg hexadecanoyl-CoA CHEBI:24544 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001968 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 597 {Octadecanoyl-CoA} <107> 597.0 nmol/min/mg stearoyl-CoA CHEBI:15541 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001969 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 488 {Octadecanoyl-CoA} <107> 488.0 nmol/min/mg stearoyl-CoA CHEBI:15541 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001970 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 258 {oleoyl-CoA} <107> 258.0 nmol/min/mg oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001971 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 304 {oleoyl-CoA} <107> 304.0 nmol/min/mg oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001972 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 577 {Palmitoleoyl-CoA} <107> 577.0 nmol/min/mg palmitoleoyl-CoA CHEBI:53152 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001973 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 661 {Palmitoleoyl-CoA} <107> 661.0 nmol/min/mg palmitoleoyl-CoA CHEBI:53152 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001974 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 912 {tetradecanoyl-CoA} <107> 912.0 nmol/min/mg myristoyl-CoA CHEBI:15532 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001975 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 766 {tetradecanoyl-CoA} <107> 766.0 nmol/min/mg myristoyl-CoA CHEBI:15532 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001976 Jenn Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.147 {glutaryl-CoA} <92> 0.147 mM glutaryl-CoA CHEBI:15524 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001977 Jenn Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 132 {glutaryl-CoA} <92> 132.0 nmol/min/mg glutaryl-CoA CHEBI:15524 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001978 Jenn Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 581 {succinyl-CoA} <92> 581.0 nmol/min/mg succinyl-CoA CHEBI:15380 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001979 Jenn Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.00034 {tetradecanoyl-CoA} <92> 0.00034 mM myristoyl-CoA CHEBI:15532 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001980 Jenn Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 137 {tetradecanoyl-CoA} <92> 137.0 nmol/min/mg myristoyl-CoA CHEBI:15532 Y Y ECO:0000006 Pubmed:16940157 PENTACON Added by PENTACON AAP 4/21/2014 3 2200001981 Jenn Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/KM #10# 0.014 {succinyl-CoA} <92> 0.014 mM succinyl-CoA CHEBI:15380 3.1.2.20 Y Y ECO:0000006 Pubmed:16940157 BRENDA <92> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001982 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #65# 0.0358 {Decanoyl-CoA} <107> 0.0358 mM decanoyl-CoA CHEBI:28493 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001983 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #64# 0.0403 {Decanoyl-CoA} <107> 0.0403 mM decanoyl-CoA CHEBI:28493 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001984 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #65# 0.0036 {Dodecanoyl-CoA} <107> 0.0036 mM lauroyl-CoA CHEBI:15521 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001985 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #64# 0.0089 {Dodecanoyl-CoA} <107> 0.0089 mM lauroyl-CoA CHEBI:15521 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001986 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #65# 0.002 {eicosanoyl-CoA} <107> 0.002 mM icosanoyl-CoA CHEBI:15527 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001987 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #64# 0.0048 {eicosanoyl-CoA} <107> 0.0048 mM icosanoyl-CoA CHEBI:15527 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001988 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #65# 0.0036 {hexadecanoyl-CoA} <107> 0.0036 mM hexadecanoyl-CoA CHEBI:24544 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001989 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2,64# 0.002 {hexadecanoyl-CoA} <60,107> 0.002 mM hexadecanoyl-CoA CHEBI:24544 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001990 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #65# 0.0024 {Octadecanoyl-CoA} <107> 0.0024 mM stearoyl-CoA CHEBI:15541 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001991 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #64# 0.0028 {Octadecanoyl-CoA} <107> 0.0028 mM stearoyl-CoA CHEBI:15541 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001992 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #65# 0.0041 {oleoyl-CoA} <107> 0.0041 mM oleoyl-CoA CHEBI:15534 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001993 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #64# 0.0061 {oleoyl-CoA} <107> 0.0061 mM oleoyl-CoA CHEBI:15534 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001994 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #65# 0.0024 {Palmitoleoyl-CoA} <107> 0.0024 mM palmitoleoyl-CoA CHEBI:53152 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001995 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #64# 0.0045 {Palmitoleoyl-CoA} <107> 0.0045 mM palmitoleoyl-CoA CHEBI:53152 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001996 Jenn Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #65# 0.0028 {tetradecanoyl-CoA} <107> 0.0028 mM myristoyl-CoA CHEBI:15532 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001997 Jenn P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #64# 0.0016 {tetradecanoyl-CoA} <107> 0.0016 mM myristoyl-CoA CHEBI:15532 3.1.2.2 Y Y ECO:0000006 Pubmed:16940157 BRENDA <107> Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.: Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. (2006) 20, 1855-1864. {Pubmed:16940157} AAP 12/7/2011 1111 2200001998 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.0075 {arachidonate} (reaction mixture contains 1 mM DTT, 1 mM ATP, 2 mM CaCl2, 0.005 mM RBx 7796 and 0.01 mM indomethacin in phosphate buffered saline, at 37°C) 0.0075 mM arachidonate CHEBI:32395 RBx 7796 CHEBI:NONE_148544 Y Y ECO:0000006 Pubmed:17039282 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: RBx 7796; reaction mixture contains 1 mM DTT, 1 mM ATP, 2 mM CaCl2, 0.005 mM RBx 7796 and 0.01 mM indomethacin in phosphate buffered saline, at 37°C AAP, DGA, AAP-M, ASD 4/21/2014 3 2200001999 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 0.0151 {RBx 7796} (in the presence of 0.003 mM arachidonate at 37°C) 0.0151 mM RBx 7796 CHEBI:NONE_148544 arachidonate CHEBI:32395 Y Y ECO:0000006 Pubmed:17039282 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: RBx 7796; in the presence of 0.03 mM arachidonate at 37°C AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002000 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 0.0593 {RBx 7796} (in the presence of 0.03 mM arachidonate at 37°C) 0.0593 mM RBx 7796 CHEBI:NONE_148544 arachidonate CHEBI:32395 Y Y ECO:0000006 Pubmed:17039282 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: RBx 7796; in the presence of 0.03 mM arachidonate at 37°C AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002001 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 26900 {arachidonate} (reaction mixture contains 1 mM DTT, 1 mM ATP, 2 mM CaCl2, 0.005 mM and 0.01 mM indomethacin in phosphate buffered saline, at 37°C) 26900.0 nmol/min/mg arachidonate CHEBI:32395 Y Y ECO:0000006 Pubmed:17039282 PENTACON Added by PENTACON; PENTACON Notes: reaction mixture contains 1 mM DTT, 1 mM ATP, 2 mM CaCl2, 0.005 mM and 0.01 mM indomethacin in phosphate buffered saline, at 37°C AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002002 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 0.0049 {RBx 7796} (in the presence of 0 arachidonate at 37°C) 0.0049 mM RBx 7796 CHEBI:NONE_148544 Y Y ECO:0000006 Pubmed:17039282 PENTACON Added by PENTACON; PENTACON Notes: in the presence of 0 arachidonate at 37°C AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002003 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0051 {arachidonate} (#3# reaction mixture contains 1 mM DTT, 1 mM ATP, 2 mM CaCl2, and 0.01 mM indomethacin in phosphate buffered saline, at 37°C <52>) <52> 0.0051 mM arachidonate CHEBI:32395 1.13.11.34 #3# reaction mixture contains 1 mM DTT, 1 mM ATP, 2 mM CaCl2, and 0.01 mM indomethacin in phosphate buffered saline, at 37°C <52> Y Y ECO:0000006 Pubmed:17039282 BRENDA <52> Shirumalla R. , S.R.; Naruganahalli K. , N.K.; Dastidar S. , D.S.; Sattigeri , S.V.; Kaur , K.G.; Deb , D.C.; Gupta J. , G.J.; Salman , S.M.; Ray , R.A.: RBx 7796: A novel inhibitor of 5-lipoxygenase. Inflamm. Res. (2006) 55, 517-527. {Pubmed:17039282} AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200002004 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2400000 {1,2-dioctanoyl-sn-glycero-3-phosphoglycol} <30> 2400000.0 nmol/min/mg 1,2-dioctanoyl-sn-glycero-3-phosphoglycol CHEBI:NONE_148545 Y Y ECO:0000006 Pubmed:1730245 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: 1,2-dioctanoyl-sn-glycero-3-phosphoglycol AAP, DGA, ASD 4/21/2014 3 2200002005 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 700000 {1,2-dinonanoyl-sn-glycero-3-phosphocholine} <30> 700000.0 nmol/min/mg 1,2-dinonanoyl-sn-glycero-3-phosphocholine CHEBI:NONE_148546 Y Y ECO:0000006 Pubmed:1730245 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: 1,2-dioctanoyl-sn-glycero-3-phosphocholine AAP, DGA, ASD 4/21/2014 3 2200002006 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1420000 {1,2-dioctanoyl-sn-glycero-3-phosphocholine} <30> 1420000.0 nmol/min/mg 1,2-dioctanoyl-sn-glycero-3-phosphocholine CHEBI:NONE_148547 Y Y ECO:0000006 Pubmed:1730245 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: 1,2-dioctanoyl-sn-glycero-3-phosphocholine AAP, DGA, ASD 4/21/2014 3 2200002007 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 4300000 {1,2-dihexanoyl-sn-glycero-3-phosphocholine} ([M8L and M20L]-loop-deleted PLA2 ) 4300000.0 nmol/min/mg 1,2-dihexanoyl-sn-glycero-3-phosphocholine CHEBI:NONE_148548 Y Y ECO:0000006 Pubmed:1730245 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: 1,2-dihexanoyl-sn-glycero-3-phosphocholine; Mutant: [M8L and M20L]-loop-deleted PLA2 AAP, DGA, ASD 4/21/2014 3 2200002008 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 6000000 {1,2-dihexanoyl-sn-glycero-3-phosphocholine} (#8# loop deleted PLA2 <30>) <30> 6000000.0 nmol/min/mg 1,2-dihexanoyl-sn-glycero-3-phosphocholine CHEBI:NONE_148548 Y Y ECO:0000006 Pubmed:1730245 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: 1,2-dihexanoyl-sn-glycero-3-phosphocholine; Mutant: loop deleted PLA2 AAP, DGA, ASD 4/21/2014 3 2200002009 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #8# 4.3 {1,2-dihexanoyl-sn-glycero-3-phosphocholine} <30> 23000.0 nmol/min/mg 1,2-dihexanoyl-sn-glycero-3-phosphocholine CHEBI:NONE_148548 Y Y ECO:0000006 Pubmed:1730245 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: 1,2-dihexanoyl-sn-glycero-3-phosphocholine AAP, DGA, ASD 4/21/2014 3 2200002010 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 135000 {1,2-diheptanoyl-sn-glycero-3-phosphocholine} <30> 135000.0 nmol/min/mg 1,2-diheptanoyl-sn-glycero-3-phosphocholine CHEBI:NONE_148549 Y Y ECO:0000006 Pubmed:1730245 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: 1,2-diheptanoyl-sn-glycero-3-phosphocholine AAP, DGA, ASD 4/21/2014 3 2200002011 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/KM #8,10# 0.1 {1,2-dioctanoyl-sn-glycero-3-phosphoglycol} <30> 0.1 mM 1,2-dioctanoyl-sn-glycero-3-phosphoglycol CHEBI:NONE_148545 3.1.1.4 Y Y ECO:0000006 Pubmed:1730245 BRENDA <30> Franken, P.A.; van den Berg, L.; Huang, J.; Gunyuzlu, P.; Lugtigheid, R.B.; Verheij, H.M.; de Haas, G.H.: Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Eur. J. Biochem. (1992) 203, 89-98. {Pubmed:1730245}; PENTACON Notes: Request ChEBI ID: 1,2-dioctanoyl-sn-glycero-3-phosphoglycol AAP, DGA, ASD 12/7/2011 1111 2200002012 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/KM #8# 0.9 {1,2-dinonanoyl-sn-glycero-3-phosphocholine} <30> 0.9 mM 1,2-dinonanoyl-sn-glycero-3-phosphocholine CHEBI:NONE_148546 3.1.1.4 Y Y ECO:0000006 Pubmed:1730245 BRENDA <30> Franken, P.A.; van den Berg, L.; Huang, J.; Gunyuzlu, P.; Lugtigheid, R.B.; Verheij, H.M.; de Haas, G.H.: Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Eur. J. Biochem. (1992) 203, 89-98. {Pubmed:1730245}; PENTACON Notes: Request ChEBI ID: 1,2-dioctanoyl-sn-glycero-3-phosphocholine AAP, DGA, ASD 12/7/2011 1111 2200002013 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/KM #8# 0.2 {1,2-dioctanoyl-sn-glycero-3-phosphocholine} <30> 0.2 mM 1,2-dioctanoyl-sn-glycero-3-phosphocholine CHEBI:NONE_148547 3.1.1.4 Y Y ECO:0000006 Pubmed:1730245 BRENDA <30> Franken, P.A.; van den Berg, L.; Huang, J.; Gunyuzlu, P.; Lugtigheid, R.B.; Verheij, H.M.; de Haas, G.H.: Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Eur. J. Biochem. (1992) 203, 89-98. {Pubmed:1730245}; PENTACON Notes: Request ChEBI ID: 1,2-dioctanoyl-sn-glycero-3-phosphocholine AAP, DGA, ASD 12/7/2011 1111 2200002014 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/KM #8# 2.4 {1,2-dihexanoyl-sn-glycero-3-phosphocholine} (#8# [M8L and M20L]-loop-deleted PLA2 <30>) <30> 2.4 mM 1,2-dihexanoyl-sn-glycero-3-phosphocholine CHEBI:NONE_148548 3.1.1.4 #8# [M8L and M20L]-loop-deleted PLA2 <30> Y Y ECO:0000006 Pubmed:1730245 BRENDA <30> Franken, P.A.; van den Berg, L.; Huang, J.; Gunyuzlu, P.; Lugtigheid, R.B.; Verheij, H.M.; de Haas, G.H.: Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Eur. J. Biochem. (1992) 203, 89-98. {Pubmed:1730245}; PENTACON Notes: Request ChEBI ID: 1,2-dihexanoyl-sn-glycero-3-phosphocholine; Mutant: [M8L and M20L]-loop-deleted PLA2 AAP, DGA, ASD 12/7/2011 1111 2200002015 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/KM #8# 2.8 {1,2-dihexanoyl-sn-glycero-3-phosphocholine} (#8# loop deleted PLA2 <30>) <30> 2.8 mM 1,2-dihexanoyl-sn-glycero-3-phosphocholine CHEBI:NONE_148548 3.1.1.4 #8# loop deleted PLA2 <30> Y Y ECO:0000006 Pubmed:1730245 BRENDA <30> Franken, P.A.; van den Berg, L.; Huang, J.; Gunyuzlu, P.; Lugtigheid, R.B.; Verheij, H.M.; de Haas, G.H.: Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Eur. J. Biochem. (1992) 203, 89-98. {Pubmed:1730245}; PENTACON Notes: Request ChEBI ID: 1,2-dihexanoyl-sn-glycero-3-phosphocholine; Mutant: loop deleted PLA2 AAP, DGA, ASD 12/7/2011 1111 2200002016 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/KM #8# 4.3 {1,2-dihexanoyl-sn-glycero-3-phosphocholine} <30> 4.3 mM 1,2-dihexanoyl-sn-glycero-3-phosphocholine CHEBI:NONE_148548 3.1.1.4 Y Y ECO:0000006 Pubmed:1730245 BRENDA <30> Franken, P.A.; van den Berg, L.; Huang, J.; Gunyuzlu, P.; Lugtigheid, R.B.; Verheij, H.M.; de Haas, G.H.: Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Eur. J. Biochem. (1992) 203, 89-98. {Pubmed:1730245}; PENTACON Notes: Request ChEBI ID: 1,2-dihexanoyl-sn-glycero-3-phosphocholine AAP, DGA, ASD 12/7/2011 1111 2200002017 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/KM #8# 3.6 {1,2-diheptanoyl-sn-glycero-3-phosphocholine} <30> 3.6 mM 1,2-diheptanoyl-sn-glycero-3-phosphocholine CHEBI:NONE_148549 3.1.1.4 Y Y ECO:0000006 Pubmed:1730245 BRENDA <30> Franken, P.A.; van den Berg, L.; Huang, J.; Gunyuzlu, P.; Lugtigheid, R.B.; Verheij, H.M.; de Haas, G.H.: Purification and characterization of a mutant human platelet phospholipase A2 expressed in Escherichia coli. Eur. J. Biochem. (1992) 203, 89-98. {Pubmed:1730245}; PENTACON Notes: Request ChEBI ID: 1,2-diheptanoyl-sn-glycero-3-phosphocholine AAP, DGA, ASD 12/7/2011 1111 2200002018 Jenn P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/KM #15# 0.0072 {arachidonic acid} (#15# cytosolic hp-12LOX, pH 7.4, recombinant wild-type enzyme <67>) <67> 0.0072 mM arachidonic acid CHEBI:15843 1.13.11.31 #15# cytosolic hp-12LOX, pH 7.4, recombinant wild-type enzyme <67> Y Y ECO:0000033 Pubmed:18155727 BRENDA <67> Aleem, A.M.; Jankun, J.; Dignam, J.D.; Walther, M.; Kuehn, H.; Svergun, D.I.; Skrzypczak-Jankun, E.: Human platelet 12-lipoxygenase, new findings about its activity, membrane binding and low-resolution structure. J. Mol. Biol. (2008) 376, 193-209. {Pubmed:18155727} AAP, DGA, AAP-M 12/7/2011 1111 2200002019 Jenn P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/KM #15# 0.0087 {arachidonic acid} (#15# membrane hp-12LOX, pH 7.4, recombinant wild-type enzyme <67>) <67> 0.0087 mM arachidonic acid CHEBI:15843 1.13.11.31 #15# membrane hp-12LOX, pH 7.4, recombinant wild-type enzyme <67> Y Y ECO:0000033 Pubmed:18155727 BRENDA <67> Aleem, A.M.; Jankun, J.; Dignam, J.D.; Walther, M.; Kuehn, H.; Svergun, D.I.; Skrzypczak-Jankun, E.: Human platelet 12-lipoxygenase, new findings about its activity, membrane binding and low-resolution structure. J. Mol. Biol. (2008) 376, 193-209. {Pubmed:18155727} AAP, DGA, AAP-M 12/7/2011 1111 2200002020 Jenn Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #5# 0.07219 {1-palmitoyl-lysophosphatidylcholine}(#5# Vmax: 6364 nmol/min/mg protein <56>) <56> 0.07219 mM 1-palmitoyl-lysophosphatidylcholine CHEBI:NONE_148550 2.3.1.23 #5# Vmax: 6364 nmol/min/mg protein <56> Y Y ECO:0000006 Pubmed:18195019 BRENDA <56> Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G.: Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem. (2008) 283, 8258-8265. {Pubmed:18195019}; PENTACON Notes: Request ChEBI ID: 1-Palmitoyl-LPC AAP 12/7/2011 1111 2200002021 Jenn Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #5# 0.07219 {1-palmitoyl-lysophosphatidylcholine}(#5# Vmax: 6364 nmol/min/mg protein <56>) <56> 6364.0 nmol/min/mg 1-palmitoyl-lysophosphatidylcholine CHEBI:NONE_148550 2.3.1.23 #5# Vmax: 6364 nmol/min/mg protein <56> Y Y ECO:0000006 Pubmed:18195019 BRENDA <56> Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G.: Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem. (2008) 283, 8258-8265. {Pubmed:18195019}; PENTACON Notes: Request ChEBI ID: 1-Palmitoyl-LPC AAP 12/7/2011 1111 2200002022 Jenn Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #5# 0.07156 {Arachidonoyl-CoA} (#5# Vmax: 6247 nmol/min/mg protein <56>) <56> 0.07156 mM arachidonoyl-CoA CHEBI:15514 2.3.1.23 #5# Vmax: 6247 nmol/min/mg protein <56> Y Y ECO:0000006 Pubmed:18195019 BRENDA <56> Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G.: Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem. (2008) 283, 8258-8265. {Pubmed:18195019} AAP 12/7/2011 1111 2200002023 Jenn Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #5# 0.07156 {Arachidonoyl-CoA} (#5# Vmax: 6247 nmol/min/mg protein <56>) <56> 6247.0 nmol/min/mg arachidonoyl-CoA CHEBI:15514 2.3.1.23 #5# Vmax: 6247 nmol/min/mg protein <56> Y Y ECO:0000006 Pubmed:18195019 BRENDA <56> Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G.: Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem. (2008) 283, 8258-8265. {Pubmed:18195019} AAP 12/7/2011 1111 2200002024 Jenn Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #5# 0.2014 {linoleoyl-CoA} (#5# Vmax: 18148 nmol/min/mg protein <56>) <56> 0.2014 mM linoleoyl-CoA CHEBI:15530 2.3.1.23 #5# Vmax: 18148 nmol/min/mg protein <56> Y Y ECO:0000006 Pubmed:18195019 BRENDA <56> Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G.: Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem. (2008) 283, 8258-8265. {Pubmed:18195019} AAP 12/7/2011 1111 2200002025 Jenn Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #5# 0.2014 {linoleoyl-CoA} (#5# Vmax: 18148 nmol/min/mg protein <56>) <56> 18148.0 nmol/min/mg linoleoyl-CoA CHEBI:15530 2.3.1.23 #5# Vmax: 18148 nmol/min/mg protein <56> Y Y ECO:0000006 Pubmed:18195019 BRENDA <56> Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G.: Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem. (2008) 283, 8258-8265. {Pubmed:18195019} AAP 12/7/2011 1111 2200002026 Jenn Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #5# 0.07268 {oleoyl-CoA} (#5# Vmax: 4698 nmol/min/mg protein <56>) <56> 0.07268 mM oleoyl-CoA CHEBI:15534 2.3.1.23 #5# Vmax: 4698 nmol/min/mg protein <56> Y Y ECO:0000006 Pubmed:18195019 BRENDA <56> Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G.: Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem. (2008) 283, 8258-8265. {Pubmed:18195019} AAP 12/7/2011 1111 2200002027 Jenn Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #5# 0.07268 {oleoyl-CoA} (#5# Vmax: 4698 nmol/min/mg protein <56>) <56> 4698.0 nmol/min/mg oleoyl-CoA CHEBI:15534 2.3.1.23 #5# Vmax: 4698 nmol/min/mg protein <56> Y Y ECO:0000006 Pubmed:18195019 BRENDA <56> Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G.: Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem. (2008) 283, 8258-8265. {Pubmed:18195019} AAP 12/7/2011 1111 2200002028 Jenn Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #5# 0.04129 {palmitoyl-CoA} (#5# Vmax: 1782 nmol/min/mg protein <56>) <56> 0.04129 mM palmitoyl-CoA CHEBI:15525 2.3.1.23 #5# Vmax: 1782 nmol/min/mg protein <56> Y Y ECO:0000006 Pubmed:18195019 BRENDA <56> Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G.: Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem. (2008) 283, 8258-8265. {Pubmed:18195019} AAP 12/7/2011 1111 2200002029 Jenn Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #5# 0.04129 {palmitoyl-CoA} (#5# Vmax: 1782 nmol/min/mg protein <56>) <56> 1782.0 nmol/min/mg palmitoyl-CoA CHEBI:15525 2.3.1.23 #5# Vmax: 1782 nmol/min/mg protein <56> Y Y ECO:0000006 Pubmed:18195019 BRENDA <56> Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G.: Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem. (2008) 283, 8258-8265. {Pubmed:18195019} AAP 12/7/2011 1111 2200002030 Jenn Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM #5# 0.03565 {stearoyl-CoA} (#5# Vmax: 996 nmol/min/mg protein <56>) <56> 0.03565 mM stearoyl-CoA CHEBI:15541 2.3.1.23 #5# Vmax: 996 nmol/min/mg protein <56> Y Y ECO:0000006 Pubmed:18195019 BRENDA <56> Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G.: Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem. (2008) 283, 8258-8265. {Pubmed:18195019} AAP 12/7/2011 1111 2200002031 Jenn Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #5# 0.03565 {stearoyl-CoA} (#5# Vmax: 996 nmol/min/mg protein <56>) <56> 996.0 nmol/min/mg stearoyl-CoA CHEBI:15541 2.3.1.23 #5# Vmax: 996 nmol/min/mg protein <56> Y Y ECO:0000006 Pubmed:18195019 BRENDA <56> Zhao, Y.; Chen, Y.Q.; Bonacci, T.M.; Bredt, D.S.; Li, S.; Bensch, W.R.; Moller, D.E.; Kowala, M.; Konrad, R.J.; Cao, G.: Identification and characterization of a major liver lysophosphatidylcholine acyltransferase. J. Biol. Chem. (2008) 283, 8258-8265. {Pubmed:18195019} AAP 12/7/2011 1111 2200002032 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 12.4 {Glycylglycine} <45> 12.4 mM glycylglycine CHEBI:17201 L-Glutamic acid gamma-(4-nitroanilide) CHEBI:NONE_148551 2.3.2.2 Y Y ECO:0000006 Pubmed:18197 BRENDA <45> Huseby, N.: Purification and some properties of gamma-glutamyltransferase from human liver. Biochim. Biophys. Acta (1977) 483, 46-56. {Pubmed:18197}; PENTACON Notes: Request ChEBI ID: L-Glutamic acid gamma-(4-nitroanilide): CID 57369855 AAP, DGA, ASD 12/7/2011 1111 2200002033 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.81 {L-Glu-4-nitroanilide} <45> 0.81 mM L-Glutamic acid gamma-(4-nitroanilide) CHEBI:NONE_148551 glycylglycine CHEBI:17201 2.3.2.2 Y Y ECO:0000006 Pubmed:18197 BRENDA <45> Huseby, N.: Purification and some properties of gamma-glutamyltransferase from human liver. Biochim. Biophys. Acta (1977) 483, 46-56. {Pubmed:18197}; PENTACON Notes: Request ChEBI ID: L-Glutamic acid gamma-(4-nitroanilide): CID 57369855 AAP, DGA, ASD 12/7/2011 1111 2200002034 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.5 {L-Glu-4-nitroanilide} (#6# recombinant wild-type <65>; #6# bile enzyme <46>) <46,65> 1.5 mM L-Glutamic acid gamma-(4-nitroanilide) CHEBI:NONE_148551 2.3.2.2 #6# recombinant wild-type <65>; #6# bile enzyme <46> Y Y ECO:0000006 Pubmed:18198 BRENDA <46> Indirani, N.; Hill, P.G.: Partial purification and some properties of gamma-glutamyl transpeptidase from human bile. Biochim. Biophys. Acta (1977) 483, 57-62. {Pubmed:18198}; PENTACON Notes: Request ChEBI ID: L-Glutamic acid gamma-(4-nitroanilide): CID 57369855; Enzyme was purified from bile and not recombinant AAP, DGA, ASD 12/7/2011 1111 2200002035 Jodi P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.003 {5,8,11,14,17-eicosapentaenoic acid} <2> 0.003 mM all-cis-5,8,11,14,17-icosapentaenoic acid CHEBI:28364 1.13.11.31 Y Y ECO:0000006 Pubmed:1851637 BRENDA <2> Hada, T.; Ueda, N.; Takahashi, Y.; Yamamoto, S.: Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins. Biochim. Biophys. Acta (1991) 1083, 89-93. {Pubmed:1851637} (c) AAP, DGA, AAP-M 12/7/2011 1111 2200002036 Jodi P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0035 {8,11,14-Eicosatrienoic acid} <2> 0.0035 mM all-cis-icosa-8,11,14-trienoic acid CHEBI:53486 1.13.11.31 Y Y ECO:0000006 Pubmed:1851637 BRENDA <2> Hada, T.; Ueda, N.; Takahashi, Y.; Yamamoto, S.: Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins. Biochim. Biophys. Acta (1991) 1083, 89-93. {Pubmed:1851637} (c) AAP, DGA, AAP-M 12/7/2011 1111 2200002037 Jodi P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.008 {arachidonic acid} <2> 0.008 mM arachidonic acid CHEBI:15843 1.13.11.31 Y Y ECO:0000006 Pubmed:1851637 BRENDA <2> Hada, T.; Ueda, N.; Takahashi, Y.; Yamamoto, S.: Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins. Biochim. Biophys. Acta (1991) 1083, 89-93. {Pubmed:1851637} (c) AAP, DGA, AAP-M 12/7/2011 1111 2200002038 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 10.8 {L-alanine-4-nitroanilide} <67> 10.8 mM alanine-4-nitroanilide CHEBI:NONE_148529 3.3.2.6 Y Y ECO:0000033 Pubmed:18539590 BRENDA <67> Bauvois, C.; Jacquamet, L.; Huston, A.L.; Borel, F.; Feller, G.; Ferrer, J.L.: Crystal structure of the cold-active aminopeptidase from Colwellia psychrerythraea, a close structural homologue of the human bifunctional leukotriene A4 hydrolase. J. Biol. Chem. (2008) 283, 23315-23325. {Pubmed:18539590}; PENTACON Notes: Request ChEBI ID: alanine-4-nitroanilide; Pubchem ID: CID 150936 AAP, ASD 12/7/2011 1111 2200002039 Jodi P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0025 {arachidonic acid} (#2# 13,13-dideuterated arachidonic acid, pH 7.5, 25°C, recombinant isozyme 15-hLO-1 <72>) <72> 0.0025 mM arachidonic acid CHEBI:15843 1.13.11.33 #2# 13,13-dideuterated arachidonic acid, pH 7.5, 25°C, recombinant isozyme 15-hLO-1 <72> Y Y ECO:0000006 Pubmed:18547056 BRENDA <72> Jacquot, C.; Wecksler, A.T.; McGinley, C.M.; Segraves, E.N.; Holman, T.R.; van der Donk, W.A.: Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry (2008) 47, 7295-7303. {Pubmed:18547056} AAP, DGA, ASD 12/7/2011 1111 2200002040 Jodi P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0037 {arachidonic acid} (#2# unlabeled substrate, pH 7.5, 25°C, recombinant isozyme 15-hLO-1 <72>) <72> 0.0037 mM arachidonic acid CHEBI:15843 1.13.11.33 #2# unlabeled substrate, pH 7.5, 25°C, recombinant isozyme 15-hLO-1 <72> Y Y ECO:0000006 Pubmed:18547056 BRENDA <72> Jacquot, C.; Wecksler, A.T.; McGinley, C.M.; Segraves, E.N.; Holman, T.R.; van der Donk, W.A.: Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry (2008) 47, 7295-7303. {Pubmed:18547056} AAP, DGA, ASD 12/7/2011 1111 2200002041 Jodi P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0034 {arachidonic acid} (#2# 10,10-dideuterated arachidonic acid, pH 7.5, 25°C, recombinant isozyme 15-hLO-1 <72>) <72> 0.0034 mM arachidonic acid CHEBI:15843 1.13.11.33 #2# 10,10-dideuterated arachidonic acid, pH 7.5, 25°C, recombinant isozyme 15-hLO-1 <72> Y Y ECO:0000006 Pubmed:18547056 BRENDA <72> Jacquot, C.; Wecksler, A.T.; McGinley, C.M.; Segraves, E.N.; Holman, T.R.; van der Donk, W.A.: Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry (2008) 47, 7295-7303. {Pubmed:18547056} AAP, DGA, ASD 12/7/2011 1111 2200002042 Jodi P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0028 {arachidonic acid} (#2# 10,10,13,13-tetradeuterated arachidonic acid, pH 7.5, 25°C, recombinant isozyme 15-hLO-1 <72>) <72> 0.0028 mM arachidonic acid CHEBI:15843 1.13.11.33 #2# 10,10,13,13-tetradeuterated arachidonic acid, pH 7.5, 25°C, recombinant isozyme 15-hLO-1 <72> Y Y ECO:0000006 Pubmed:18547056 BRENDA <72> Jacquot, C.; Wecksler, A.T.; McGinley, C.M.; Segraves, E.N.; Holman, T.R.; van der Donk, W.A.: Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry (2008) 47, 7295-7303. {Pubmed:18547056} AAP, DGA, ASD 12/7/2011 1111 2200002043 Christie P15428 3248 HPGD Homo sapiens 9606 #4# 0.0521 {15-ketoprostaglandin E1} (#4# at pH 7.0 <5>) <5> 0.0521 mM 15-dehydro-prostaglandin E1(1-) CHEBI:57401 NADH CHEBI:16908 1.1.1.141 #4# at pH 7.0 <5> Y Y ECO:0000006 Pubmed:187123 BRENDA <5> Jabarak, J.; Braithwaite, S.S.: Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch. Biochem. Biophys. (1976) 177, 245-254. {Pubmed:187123} AAP, ASD 12/7/2011 1111 2200002044 Christie P15428 3248 HPGD Homo sapiens 9606 #4# 0.0156 {NADH} (#4# at pH 7.0, + 15-keto-PGE1 <5>; #4# at pH 7.0<5>) <5> 0.0156 mM NADH CHEBI:16908 15-dehydro-prostaglandin E1(1-) CHEBI:57401 1.1.1.141 #4# at pH 7.0, + 15-keto-PGE1 <5>; #4# at pH 7.0, + 15-ketoprostaglandin E2 <5> Y Y ECO:0000006 Pubmed:187123 BRENDA <5> Jabarak, J.; Braithwaite, S.S.: Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch. Biochem. Biophys. (1976) 177, 245-254. {Pubmed:187123} AAP, ASD 12/7/2011 1111 2200002045 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0528 {15-Ketoprostaglandin E2} (#4# at pH 7.0 <5>) <5> 0.0528 mM 15-dehydro-prostaglandin E2 CHEBI:15547 NADH CHEBI:16908 1.1.1.141 #4# at pH 7.0 <5> Y Y ECO:0000006 Pubmed:187123 BRENDA <5> Jabarak, J.; Braithwaite, S.S.: Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch. Biochem. Biophys. (1976) 177, 245-254. {Pubmed:187123} AAP, ASD 12/7/2011 1111 2200002046 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0266 {15-Ketoprostaglandin E2} (#4# at pH 9.0 <5>) <5> 0.0266 mM 15-dehydro-prostaglandin E2 CHEBI:15547 NADH CHEBI:16908 1.1.1.141 #4# at pH 9.0 <5> Y Y ECO:0000006 Pubmed:187123 BRENDA <5> Jabarak, J.; Braithwaite, S.S.: Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch. Biochem. Biophys. (1976) 177, 245-254. {Pubmed:187123} AAP, ASD 12/7/2011 1111 2200002047 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.029 {NAD+} (#4# at pH 9.0, + prostaglandin E1 <5>) <5> 0.029 mM NAD(+) CHEBI:15846 prostaglandin E1 CHEBI:15544 1.1.1.141 #4# at pH 9.0, + prostaglandin E1 <5> Y Y ECO:0000006 Pubmed:187123 BRENDA <5> Jabarak, J.; Braithwaite, S.S.: Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch. Biochem. Biophys. (1976) 177, 245-254. {Pubmed:187123} AAP, ASD 12/7/2011 1111 2200002048 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0227 {NAD+} (#4# at pH 9.0, + prostaglandin E2 <5>) <5> 0.0227 mM NAD(+) CHEBI:15846 prostaglandin E2 CHEBI:15551 1.1.1.141 #4# at pH 9.0, + prostaglandin E2 <5> Y Y ECO:0000006 Pubmed:187123 BRENDA <5> Jabarak, J.; Braithwaite, S.S.: Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch. Biochem. Biophys. (1976) 177, 245-254. {Pubmed:187123} AAP, ASD 12/7/2011 1111 2200002049 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0308 {NAD+} (#4# at pH 7.0, + prostaglandin E1 <5>) <5> 0.0308 mM NAD(+) CHEBI:15846 prostaglandin E1 CHEBI:15544 1.1.1.141 #4# at pH 7.0, + prostaglandin E1 <5> Y Y ECO:0000006 Pubmed:187123 BRENDA <5> Jabarak, J.; Braithwaite, S.S.: Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch. Biochem. Biophys. (1976) 177, 245-254. {Pubmed:187123} AAP, ASD 12/7/2011 1111 2200002050 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0284 {NAD+} (#4# at pH 7.0, + prostaglandin E2 <5>) <5> 0.0284 mM NAD(+) CHEBI:15846 prostaglandin E2 CHEBI:15551 1.1.1.141 #4# at pH 7.0, + prostaglandin E2 <5> Y Y ECO:0000006 Pubmed:187123 BRENDA <5> Jabarak, J.; Braithwaite, S.S.: Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch. Biochem. Biophys. (1976) 177, 245-254. {Pubmed:187123} AAP, ASD 12/7/2011 1111 2200002051 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0594 {NADH} (#4# at pH 9.0, + 15-ketoprostaglandin E2 <5>) <5> 0.0594 mM NADH CHEBI:16908 15-dehydro-prostaglandin E2 CHEBI:15547 1.1.1.141 #4# at pH 9.0, + 15-ketoprostaglandin E2 <5> Y Y ECO:0000006 Pubmed:187123 BRENDA <5> Jabarak, J.; Braithwaite, S.S.: Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch. Biochem. Biophys. (1976) 177, 245-254. {Pubmed:187123} AAP, ASD 12/7/2011 1111 2200002052 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0156 {NADH} (#4# at pH 7.0, + 15-ketoprostaglandin E2 <5>) <5> 0.0156 mM NADH CHEBI:16908 15-dehydro-prostaglandin E2 CHEBI:15547 1.1.1.141 #4# at pH 7.0, + 15-keto-PGE1 <5>; #4# at pH 7.0, + 15-ketoprostaglandin E2 <5> Y Y ECO:0000006 Pubmed:187123 BRENDA <5> Jabarak, J.; Braithwaite, S.S.: Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch. Biochem. Biophys. (1976) 177, 245-254. {Pubmed:187123} AAP, ASD 12/7/2011 1111 2200002053 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0013 {prostaglandin E1} (#4# at pH 7.0 <5>) <5,12> 0.0013 mM prostaglandin E1 CHEBI:15544 NAD(+) CHEBI:15846 1.1.1.141 #4# at pH 7.0 <5> Y Y ECO:0000006 Pubmed:187123 BRENDA <5> Jabarak, J.; Braithwaite, S.S.: Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch. Biochem. Biophys. (1976) 177, 245-254. {Pubmed:187123} AAP, ASD 12/7/2011 1111 2200002054 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0048 {prostaglandin E1} (#4# at pH 9.0 <5>) <5,12> 0.0048 mM prostaglandin E1 CHEBI:15544 NAD(+) CHEBI:15846 1.1.1.141 #4# at pH 9.0 <5> Y Y ECO:0000006 Pubmed:187123 BRENDA <5> Jabarak, J.; Braithwaite, S.S.: Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch. Biochem. Biophys. (1976) 177, 245-254. {Pubmed:187123} AAP, ASD 12/7/2011 1111 2200002055 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0025 {prostaglandin E2} (#4# at pH 7.0 <5>) <5> 0.0025 mM prostaglandin E2 CHEBI:15551 NAD(+) CHEBI:15846 1.1.1.141 #4# at pH 7.0 <5> Y Y ECO:0000006 Pubmed:187123 BRENDA <5> Jabarak, J.; Braithwaite, S.S.: Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch. Biochem. Biophys. (1976) 177, 245-254. {Pubmed:187123} AAP, ASD 12/7/2011 1111 2200002056 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0028 {prostaglandin E2} (#4# at pH 9.0 <5>) <5> 0.0028 mM prostaglandin E2 CHEBI:15551 NAD(+) CHEBI:15846 1.1.1.141 #4# at pH 9.0 <5> Y Y ECO:0000006 Pubmed:187123 BRENDA <5> Jabarak, J.; Braithwaite, S.S.: Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. Arch. Biochem. Biophys. (1976) 177, 245-254. {Pubmed:187123} AAP, ASD 12/7/2011 1111 2200002057 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 1.9 {L-Ala-p-nitroanilide} (#4# mutant enzyme E296Q, 500 mM KCl in 250 mM Tris buffer (pH 7.5) <64>; #4# wild type enzyme, 500 mM KCl in 250 mM Tris buffer (pH 7.5) <64>) <64> 1.9 mM alanine-4-nitroanilide CHEBI:NONE_148529 3.3.2.6 #4# mutant enzyme E296Q, 500 mM KCl in 250 mM Tris buffer (pH 7.5 Y Y ECO:0000006 Pubmed:18804029 BRENDA <64> Tholander, F.; Muroya, A.; Roques, B.P.; Fournie-Zaluski, M.C.; Thunnissen, M.M.; Haeggstroem, J.Z.: Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design. Chem. Biol. (2008) 15, 920-929. {Pubmed:18804029}; PENTACON Notes: wild type enzyme; Request ChEBI ID: alanine-4-nitroanilide; Pubchem ID: CID 150936 AAP, ASD 12/7/2011 1111 2200002058 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 1.5 {L-Arg-p-nitroanilide} (#4# wild type enzyme, 500 mM KCl in 250 mM Tris buffer (pH 7.5) <64>) <64> 1.5 mM L-Arg-p-nitroanilide CHEBI:NONE_148553 3.3.2.6 #4# wild type enzyme, 500 mM KCl in 250 mM Tris buffer (pH 7.5 Y Y ECO:0000006 Pubmed:18804029 BRENDA <64> Tholander, F.; Muroya, A.; Roques, B.P.; Fournie-Zaluski, M.C.; Thunnissen, M.M.; Haeggstroem, J.Z.: Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design. Chem. Biol. (2008) 15, 920-929. {Pubmed:18804029}; PENTACON Notes: Request ChEBI ID: L-Arg-p-nitroanilide; Pubchem ID: CID 7408187 AAP, ASD 12/7/2011 1111 2200002059 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 1.3 {Arg-Ser-Arg} (#4# wild type enzyme, 500 mM KCl in 250 mM Tris buffer (pH 7.5) <64>) <64> 1.3 mM Arg-Ser-Arg CHEBI:NONE_148554 3.3.2.6 #4# wild type enzyme, 500 mM KCl in 250 mM Tris buffer (pH 7.5 Y Y ECO:0000006 Pubmed:18804029 BRENDA <64> Tholander, F.; Muroya, A.; Roques, B.P.; Fournie-Zaluski, M.C.; Thunnissen, M.M.; Haeggstroem, J.Z.: Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design. Chem. Biol. (2008) 15, 920-929. {Pubmed:18804029}; PENTACON Notes: Request ChEBI ID: Arg-Ser-Arg AAP, ASD 12/7/2011 1111 2200002060 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 2.2 {L-Arg-p-nitroanilide} (#4# mutant enzyme E296Q, 500 mM KCl in 250 mM Tris buffer (pH 7.5) <64>) <64> 2.2 mM L-Arg-p-nitroanilide CHEBI:NONE_148553 3.3.2.6 #4# mutant enzyme E296Q, 500 mM KCl in 250 mM Tris buffer (pH 7.5 Y Y ECO:0000006 Pubmed:18804029 BRENDA <64> Tholander, F.; Muroya, A.; Roques, B.P.; Fournie-Zaluski, M.C.; Thunnissen, M.M.; Haeggstroem, J.Z.: Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design. Chem. Biol. (2008) 15, 920-929. {Pubmed:18804029}; PENTACON Notes: Mutant: E296Q; Request ChEBI ID: L-Arg-p-nitroanilide; Pubchem ID: CID 7408187 AAP, ASD 12/7/2011 1111 2200002061 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 1.9 {L-Ala-p-nitroanilide} (#4# mutant enzyme E296Q, 500 mM KCl in 250 mM Tris buffer (pH 7.5) <64>; #4# wild type enzyme, 500 mM KCl in 250 mM Tris buffer (pH 7.5) <64>) <64> 1.9 mM alanine-4-nitroanilide CHEBI:NONE_148529 3.3.2.6 #4# mutant enzyme E296Q, 500 mM KCl in 250 mM Tris buffer (pH 7.5 Y Y ECO:0000006 Pubmed:18804029 BRENDA <64> Tholander, F.; Muroya, A.; Roques, B.P.; Fournie-Zaluski, M.C.; Thunnissen, M.M.; Haeggstroem, J.Z.: Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design. Chem. Biol. (2008) 15, 920-929. {Pubmed:18804029}; PENTACON Notes: Mutant: E296Q; Request ChEBI ID: alanine-4-nitroanilide; Pubchem ID: CID 150936 AAP, ASD 12/7/2011 1111 2200002062 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 3 {L-Ala-p-nitroanilide} (#4# mutant enzyme D375A, 500 mM KCl in 250 mM Tris buffer (pH 7.5) <64>) <64> 3.0 mM alanine-4-nitroanilide CHEBI:NONE_148529 3.3.2.6 #4# mutant enzyme D375A, 500 mM KCl in 250 mM Tris buffer (pH 7.5 Y Y ECO:0000006 Pubmed:18804029 BRENDA <64> Tholander, F.; Muroya, A.; Roques, B.P.; Fournie-Zaluski, M.C.; Thunnissen, M.M.; Haeggstroem, J.Z.: Structure-based dissection of the active site chemistry of leukotriene A4 hydrolase: implications for M1 aminopeptidases and inhibitor design. Chem. Biol. (2008) 15, 920-929. {Pubmed:18804029}; PENTACON Notes: Mutant: D375A; Request ChEBI ID: alanine-4-nitroanilide; Pubchem ID: CID 150936 AAP, ASD 12/7/2011 1111 2200002063 Jodi P33261 1557 CYP2C19 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.018 {fenthion-sulfoxide} (#3# CYP2C19 <60>) <60> 0.018 mM fenthion-sulfoxide CHEBI:NONE_148555 1.14.14.1 #3# CYP2C19 <60> Y Y ECO:0000006 Pubmed:18845175 BRENDA <60> Leoni, C.; Buratti, F.M.; Testai, E.: The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol. Appl. Pharmacol. (2008) 233, 343-352. {Pubmed:18845175}; PENTACON Notes: Request ChEBI ID: fenthion-sulfoxide; Pubchem ID: CID 19577 AAP, DGA, ASD 12/7/2011 1111 2200002064 Jodi P04798 1543 CYP1A1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.008 {fenthion} (#3# CYP1A1, sulfoxidation to fenthion-sulfoxide <60>) <60> 0.008 mM fenthion CHEBI:34761 1.14.14.1 #3# CYP1A1, sulfoxidation to fenthion-sulfoxide <60> Y Y ECO:0000006 Pubmed:18845175 BRENDA <60> Leoni, C.; Buratti, F.M.; Testai, E.: The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol. Appl. Pharmacol. (2008) 233, 343-352. {Pubmed:18845175} AAP, DGA, ASD 12/7/2011 1111 2200002065 Jodi P05177 1544 CYP1A2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #62# 0.0016 {fenthion} (#62# desulfuration by recombinant human CYPs to fenthion-oxon <60>) <60> 0.0016 mM fenthion CHEBI:34761 1.14.14.1 #62# desulfuration by recombinant human CYPs to fenthion-oxon <60> Y Y ECO:0000006 Pubmed:18845175 BRENDA <60> Leoni, C.; Buratti, F.M.; Testai, E.: The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol. Appl. Pharmacol. (2008) 233, 343-352. {Pubmed:18845175} AAP, DGA, ASD 12/7/2011 1111 2200002066 Jodi P05177 1544 CYP1A2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #62# 0.0022 {fenthion} (#62# sulfoxidation to fenthion-sulfoxide <60>) <60> 0.0022 mM fenthion CHEBI:34761 1.14.14.1 #62# sulfoxidation to fenthion-sulfoxide <60> Y Y ECO:0000006 Pubmed:18845175 BRENDA <60> Leoni, C.; Buratti, F.M.; Testai, E.: The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol. Appl. Pharmacol. (2008) 233, 343-352. {Pubmed:18845175} AAP, DGA, ASD 12/7/2011 1111 2200002067 Jodi P20813 1555 CYP2B6 Homo sapiens 9606 Comment/biophysicochemical properties/KM #64# 0.01 {fenthion} (#64# sulfoxidation to fenthion-sulfoxide <60>) <60> 0.01 mM fenthion CHEBI:34761 1.14.14.1 #64# sulfoxidation to fenthion-sulfoxide <60> Y Y ECO:0000006 Pubmed:18845175 BRENDA <60> Leoni, C.; Buratti, F.M.; Testai, E.: The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol. Appl. Pharmacol. (2008) 233, 343-352. {Pubmed:18845175} AAP, ASD 12/7/2011 1111 2200002068 Jodi P20813 1555 CYP2B6 Homo sapiens 9606 Comment/biophysicochemical properties/KM #64# 0.0027 {fenthion} (#64# desulfuration by recombinant human CYPs to fenthion-oxon <60>) <60> 0.0027 mM fenthion CHEBI:34761 1.14.14.1 #64# desulfuration by recombinant human CYPs to fenthion-oxon <60> Y Y ECO:0000006 Pubmed:18845175 BRENDA <60> Leoni, C.; Buratti, F.M.; Testai, E.: The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol. Appl. Pharmacol. (2008) 233, 343-352. {Pubmed:18845175} AAP, ASD 12/7/2011 1111 2200002069 Jodi P33261 1557 CYP2C19 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0024 {fenthion} (#3# CYP2C19, desulfuration by recombinant human CYPs to fenthion-oxon <60>) <60> 0.0024 mM fenthion CHEBI:34761 1.14.14.1 #3# CYP2C19, desulfuration by recombinant human CYPs to fenthion-oxon <60> Y Y ECO:0000006 Pubmed:18845175 BRENDA <60> Leoni, C.; Buratti, F.M.; Testai, E.: The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol. Appl. Pharmacol. (2008) 233, 343-352. {Pubmed:18845175} AAP, DGA, ASD 12/7/2011 1111 2200002070 Jodi P33261 1557 CYP2C19 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0044 {fenthion} (#3# CYP2C19, sulfoxidation to fenthion-sulfoxide <60>) <60> 0.0044 mM fenthion CHEBI:34761 1.14.14.1 #3# CYP2C19, sulfoxidation to fenthion-sulfoxide <60> Y Y ECO:0000006 Pubmed:18845175 BRENDA <60> Leoni, C.; Buratti, F.M.; Testai, E.: The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol. Appl. Pharmacol. (2008) 233, 343-352. {Pubmed:18845175} AAP, DGA, ASD 12/7/2011 1111 2200002071 Jodi P11712 1559 CYP2C9 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.012 {fenthion} (#3# CYP2C9, desulfuration by recombinant human CYPs to fenthion-oxon <60>) <60> 0.012 mM fenthion CHEBI:34761 1.14.14.1 #3# CYP2C9, desulfuration by recombinant human CYPs to fenthion-oxon <60> Y Y ECO:0000006 Pubmed:18845175 BRENDA <60> Leoni, C.; Buratti, F.M.; Testai, E.: The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol. Appl. Pharmacol. (2008) 233, 343-352. {Pubmed:18845175} AAP, DGA, ASD 12/7/2011 1111 2200002072 Jodi P11712 1559 CYP2C9 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.006 {fenthion} (#3# CYP2C9, sulfoxidation to fenthion-sulfoxide <60>) <60> 0.006 mM fenthion CHEBI:34761 1.14.14.1 #3# CYP2C9, sulfoxidation to fenthion-sulfoxide <60> Y Y ECO:0000006 Pubmed:18845175 BRENDA <60> Leoni, C.; Buratti, F.M.; Testai, E.: The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol. Appl. Pharmacol. (2008) 233, 343-352. {Pubmed:18845175} AAP, DGA, ASD 12/7/2011 1111 2200002073 Jodi P08684 1576 CYP3A4 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.089 {fenthion} (#3# CYP3A4, desulfuration by recombinant human CYPs to fenthion-oxon <60>) <60> 0.089 mM fenthion CHEBI:34761 1.14.14.1 #3# CYP3A4, desulfuration by recombinant human CYPs to fenthion-oxon <60> Y Y ECO:0000006 Pubmed:18845175 BRENDA <60> Leoni, C.; Buratti, F.M.; Testai, E.: The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol. Appl. Pharmacol. (2008) 233, 343-352. {Pubmed:18845175} AAP, DGA, ASD 12/7/2011 1111 2200002074 Jodi P08684 1576 CYP3A4 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.131 {fenthion} (#3# CYP3A4, sulfoxidation to fenthion-sulfoxide <60>) <60> 0.131 mM fenthion CHEBI:34761 1.14.14.1 #3# CYP3A4, sulfoxidation to fenthion-sulfoxide <60> Y Y ECO:0000006 Pubmed:18845175 BRENDA <60> Leoni, C.; Buratti, F.M.; Testai, E.: The participation of human hepatic P450 isoforms, flavin-containing monooxygenases and aldehyde oxidase in the biotransformation of the insecticide fenthion. Toxicol. Appl. Pharmacol. (2008) 233, 343-352. {Pubmed:18845175} AAP, DGA, ASD 12/7/2011 1111 2200002075 Jenn P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.0003 {arachidonate} <116> 0.0003 mM arachidonate CHEBI:32395 Y Y ECO:0000006 Pubmed:18972057 PENTACON Added by PENTACON AAP, DGA, AAP-M 4/21/2014 3 2200002076 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.005 {arachidonate} <116> 0.005 mM arachidonate CHEBI:32395 1.13.11.33 Y Y ECO:0000006 Pubmed:18972057 BRENDA <116> Jacquot, C.; McGinley, C.M.; Plata, E.; Holman, T.R.; van der Donk, W.A.: Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases. Org. Biomol. Chem. (2008) 6, 4242-4252. {Pubmed:18972057} AAP, DGA, ASD 12/7/2011 1111 2200002077 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0062 {Linoleic acid} <116> 0.0062 mM linoleic acid CHEBI:17351 1.13.11.33 Y Y ECO:0000006 Pubmed:18972057 BRENDA <116> Jacquot, C.; McGinley, C.M.; Plata, E.; Holman, T.R.; van der Donk, W.A.: Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases. Org. Biomol. Chem. (2008) 6, 4242-4252. {Pubmed:18972057} AAP, DGA, ASD 12/7/2011 1111 2200002078 Chandra P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 21.4 {cholesterol} (#3# in cholesterol-lecithin vesicles <13>) <13> 21.4 mM cholesterol CHEBI:16113 2.3.1.43 #3# in cholesterol-lecithin vesicles <13> Y Y ECO:0000006 Pubmed:1901219 BRENDA <13> Collet, X.; Fielding, C.J.: Effects of inhibitors of N-linked oligosaccharide processing on the secretion, stability, and activity of lecithin:cholesterol acyltransferase. Biochemistry (1991) 30, 3228-3234. {Pubmed:1901219} AAP, DGA 12/7/2011 1111 2200002079 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.025 {3,5-dihydroxyphenylacetyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.025 mM 3,5-dihydroxyphenylacetyl-CoA CHEBI:NONE_148556 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545}; PENTACON Notes: Request ChEBI ID: 3,5-Dihydroxyphenylacetyl-CoA; Pubchem ID: CID 71448900 AAP, ASD 12/7/2011 1111 2200002080 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.01 {3,4-dihydroxyphenylacetyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.01 mM 3,4-dihydroxyphenylacetyl-CoA CHEBI:NONE_148557 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545}; PENTACON Notes: Request ChEBI ID: 3,4-dihydroxyphenylacetyl-CoA AAP, ASD 12/7/2011 1111 2200002081 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.041 {3-hydroxyphenylacetyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.041 mM 3-hydroxyphenylacetyl-CoA CHEBI:NONE_148558 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545}; PENTACON Notes: Request ChEBI ID: 3-HYDROXYPHENYLACETYL-COA, CID 25245569 AAP, ASD 12/7/2011 1111 2200002082 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.16 {3-hydroxyphenylacetyl-CoA} (#58# T69A mutant protein, pH7.5, 25°C <107>) <107> 0.16 mM 3-hydroxyphenylacetyl-CoA CHEBI:NONE_148558 3.1.2.20 #58# T69A mutant protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545}; PENTACON Notes: Mutant: T69A mutant protein, Request ChEBI ID: 3-HYDROXYPHENYLACETYL-COA; Pubchem ID: CID 25245569 AAP, ASD 12/7/2011 1111 2200002083 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.31 {3-hydroxyphenylacetyl-CoA} (#58# S83A mutant protein, pH7.5, 25°C <107>) <107> 0.31 mM 3-hydroxyphenylacetyl-CoA CHEBI:NONE_148558 3.1.2.20 #58# S83A mutant protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545}; PENTACON Notes: Mutant: S83A; Request ChEBI ID: 3-HYDROXYPHENYLACETYL-COA, CID 25245569 AAP, ASD 12/7/2011 1111 2200002084 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.3 {3-hydroxyphenylacetyl-CoA} (#58# N50A mutant protein, pH7.5, 25°C <107>) <107> 0.3 mM 3-hydroxyphenylacetyl-CoA CHEBI:NONE_148558 3.1.2.20 #58# N50A mutant protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545}; PENTACON Notes: Mutant: N50A mutant protein, Request ChEBI ID: 3-HYDROXYPHENYLACETYL-COA; Pubchem ID: CID 25245569 AAP, ASD 12/7/2011 1111 2200002085 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.12 {3-hydroxyphenylacetyl-CoA} (#58# K136A mutant protein, pH7.5, 25°C <107>) <107> 0.12 mM 3-hydroxyphenylacetyl-CoA CHEBI:NONE_148558 3.1.2.20 #58# K136A mutant protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545}; PENTACON Notes: Mutant: K136A; Request ChEBI ID: 3-HYDROXYPHENYLACETYL-COA, CID 25245569 AAP, ASD 12/7/2011 1111 2200002086 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.026 {3-hydroxyphenylacetyl-CoA} (#58# H56A mutant protein, pH7.5, 25°C <107>) <107> 0.026 mM 3-hydroxyphenylacetyl-CoA CHEBI:NONE_148558 3.1.2.20 #58# H56A mutant protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545}; PENTACON Notes: Mutant: H56A; Request ChEBI ID: 3-HYDROXYPHENYLACETYL-COA, CID 25245569 AAP, ASD 12/7/2011 1111 2200002087 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.9 {3-hydroxyphenylacetyl-CoA} (#58# H137A mutant protein, pH7.5, 25°C <107>) <107> 0.9 mM 3-hydroxyphenylacetyl-CoA CHEBI:NONE_148558 3.1.2.20 #58# H137A mutant protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545}; PENTACON Notes: Mutant: H137A; Request ChEBI ID: 3-HYDROXYPHENYLACETYL-COA, CID 25245569 AAP, ASD 12/7/2011 1111 2200002088 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.62 {3-hydroxyphenylacetyl-CoA} (#58# H134A mutant protein, pH7.5, 25°C <107>) <107> 0.62 mM 3-hydroxyphenylacetyl-CoA CHEBI:NONE_148558 3.1.2.20 #58# H134A mutant protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545}; PENTACON Notes: Mutant: H134A; Request ChEBI ID: 3-HYDROXYPHENYLACETYL-COA, CID 25245569 AAP, ASD 12/7/2011 1111 2200002089 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.36 {3-hydroxyphenylacetyl-CoA} (#58# D65N mutant protein, pH7.5, 25°C <107>) <107> 0.36 mM 3-hydroxyphenylacetyl-CoA CHEBI:NONE_148558 3.1.2.20 #58# D65N mutant protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545}; PENTACON Notes: Mutant: D65N; Request ChEBI ID: 3-HYDROXYPHENYLACETYL-COA, CID 25245569 AAP, ASD 12/7/2011 1111 2200002090 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.23 {3-hydroxyphenylacetyl-CoA} (#58# D65E mutant protein, pH7.5, 25°C <107>) <107> 0.23 mM 3-hydroxyphenylacetyl-CoA CHEBI:NONE_148558 3.1.2.20 #58# D65E mutant protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545}; PENTACON Notes: Mutant: D64E; Request ChEBI ID: 3-HYDROXYPHENYLACETYL-COA, CID 25245569 AAP, ASD 12/7/2011 1111 2200002091 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.22 {2-butenoyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.22 mM butenoyl-CoA CHEBI:22961 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002092 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 2.9 {3-hydroxy-3-methylglutaryl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 2.9 mM 3-hydroxy-3-methylglutaryl-CoA CHEBI:11814 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002093 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.032 {3-Hydroxybenzoyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.032 mM 3-hydroxybenzoyl-CoA CHEBI:15484 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002094 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.13 {4-chlorobenzoyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.13 mM 4-chlorobenzoyl-CoA CHEBI:15498 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002095 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.049 {4-hydroxyphenylacetyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.049 mM 4-hydroxyphenylacetyl-CoA CHEBI:28773 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002096 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.29 {acetyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.29 mM acetyl-CoA CHEBI:15351 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002097 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.02 {Arachidonoyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.02 mM arachidonoyl-CoA CHEBI:15514 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002098 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.11 {beta-hydroxybutyryl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.11 mM 3-hydroxybutanoyl-CoA CHEBI:37050 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002099 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.12 {beta-methylcrotonyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.12 mM 3-methylbut-2-enoyl-CoA CHEBI:15486 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002100 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.18 {crotonyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.18 mM crotonoyl-CoA CHEBI:15473 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002101 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.67 {Glutaryl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.67 mM glutaryl-CoA CHEBI:15524 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002102 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.0099 {Lauroyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.0099 mM lauroyl-CoA CHEBI:15521 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002103 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.31 {linoleoyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.31 mM linoleoyl-CoA CHEBI:15530 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002104 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.28 {malonyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.28 mM malonyl-CoA CHEBI:15531 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002105 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.21 {methylmalonyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.21 mM methylmalonyl-CoA CHEBI:16625 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002106 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.005 {myristoyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.005 mM myristoyl-CoA CHEBI:15532 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002107 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.009 {myristoyl-CoA} (#58# wild-type protein, pH7.5, 37°C <107>) <107> 0.009 mM myristoyl-CoA CHEBI:15532 3.1.2.20 #58# wild-type protein, pH7.5, 37°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002108 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.6 {n-Butyryl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.6 mM butyryl-CoA CHEBI:15517 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002109 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.0049 {n-Decanoyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.0049 mM decanoyl-CoA CHEBI:28493 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002110 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.07 {n-Hexanoyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.07 mM hexanoyl-CoA CHEBI:27540 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002111 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.026 {n-Octanoyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.026 mM octanoyl-CoA CHEBI:15533 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002112 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.016 {n-palmitoyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.016 mM palmitoyl-CoA CHEBI:15525 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002113 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.19 {n-propionyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.19 mM propionyl-CoA CHEBI:15539 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002114 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.009 {oleoyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.009 mM oleoyl-CoA CHEBI:15534 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002115 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.009 {Palmitoleoyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.009 mM palmitoleoyl-CoA CHEBI:53152 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002116 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.24 {phenylacetyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.24 mM phenylacetyl-CoA CHEBI:15537 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002117 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.02 {stearoyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.02 mM stearoyl-CoA CHEBI:15541 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002118 Jenn Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM #58# 0.25 {tiglyl-CoA} (#58# wild-type protein, pH7.5, 25°C <107>) <107> 0.25 mM 2-methylcrotonoyl-CoA CHEBI:15478 3.1.2.20 #58# wild-type protein, pH7.5, 25°C <107> Y Y ECO:0000006 Pubmed:19170545 BRENDA <107> Cao, J.; Xu, H.; Zhao, H.; Gong, W.; Dunaway-Mariano, D.: The mechanisms of human hotdog-fold thioesterase 2 (hTHEM2) substrate recognition and catalysis illuminated by a structure and function based analysis. Biochemistry (2009) 48, 1293-1304. {Pubmed:19170545} AAP, ASD 12/7/2011 1111 2200002119 Jenn O15120 10555 AGPAT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0004 {acyl-CoA} (#4# pH 7.4, 37°C, recombinant <53>) <53> 0.0027 mM acyl-CoA CHEBI:17984 Y Y ECO:0000006 Pubmed:19318427 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 37°C, recombinant AAP 4/21/2014 3 2200002120 Jenn O15120 10555 AGPAT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.002 {LPA} (#4# pH 7.4, 37°C, recombinant<53>) <53> 0.002 mM 1-octadec-9-enoylglycero-3-phosphate CHEBI:52288 Y Y ECO:0000006 Pubmed:19318427 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 37°C, recombinant AAP 4/21/2014 3 2200002121 Christie Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/K0.5 #22# 0.214 {alpha-linolenoyl-CoA} (#22# 28°C, no cooperativity: Hill number 1.0 <64>) <64> 0.214 mM alpha-linolenoyl-CoA CHEBI:51985 2.3.1.23 #22# 28°C, no cooperativity: Hill number 1.0 <64> Y Y ECO:0000006 Pubmed:19351971 BRENDA <64> Jain, S.; Zhang, X.; Khandelwal, P.J.; Saunders, A.J.; Cummings, B.S.; Oelkers, P.: Characterization of human lysophospholipid acyltransferase 3. J. Lipid Res. (2009) 50, 1563-1570. {Pubmed:19351971} AAP 12/7/2011 1111 2200002122 Christie Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/K0.5 #22# 0.245 {Arachidonoyl-CoA} (#22# 37°C, cooperativity: Hill number 2.0 <64>) <64> 0.245 mM arachidonoyl-CoA CHEBI:15514 2.3.1.23 #22# 37°C, cooperativity: Hill number 2.0 <64> Y Y ECO:0000006 Pubmed:19351971 BRENDA <64> Jain, S.; Zhang, X.; Khandelwal, P.J.; Saunders, A.J.; Cummings, B.S.; Oelkers, P.: Characterization of human lysophospholipid acyltransferase 3. J. Lipid Res. (2009) 50, 1563-1570. {Pubmed:19351971} AAP 12/7/2011 1111 2200002123 Christie Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/K0.5 #22# 0.0558 {Arachidonoyl-CoA} (#22# 28°C, cooperativity: Hill number 2.0 <64>) <64> 0.0558 mM arachidonoyl-CoA CHEBI:15514 2.3.1.23 #22# 28°C, cooperativity: Hill number 2.0 <64> Y Y ECO:0000006 Pubmed:19351971 BRENDA <64> Jain, S.; Zhang, X.; Khandelwal, P.J.; Saunders, A.J.; Cummings, B.S.; Oelkers, P.: Characterization of human lysophospholipid acyltransferase 3. J. Lipid Res. (2009) 50, 1563-1570. {Pubmed:19351971} AAP 12/7/2011 1111 2200002124 Christie Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/K0.5 #22# 0.0131 {Lysophosphatidylcholine} (#22# cooperativity: Hill number 1.7 <64>) <64> 0.0131 mM lysophosphatidylcholine 16:0 CHEBI:64563 2.3.1.23 #22# cooperativity: Hill number 1.7 <64> Y Y ECO:0000006 Pubmed:19351971 BRENDA <64> Jain, S.; Zhang, X.; Khandelwal, P.J.; Saunders, A.J.; Cummings, B.S.; Oelkers, P.: Characterization of human lysophospholipid acyltransferase 3. J. Lipid Res. (2009) 50, 1563-1570. {Pubmed:19351971} AAP 12/7/2011 1111 2200002125 Christie Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/K0.5 #22# 0.0122 {oleoyl-CoA} (#22# 37°C, cooperativity: Hill number 1.6 <64>) <64> 0.0122 mM oleoyl-CoA CHEBI:15534 2.3.1.23 #22# 37°C, cooperativity: Hill number 1.6 <64> Y Y ECO:0000006 Pubmed:19351971 BRENDA <64> Jain, S.; Zhang, X.; Khandelwal, P.J.; Saunders, A.J.; Cummings, B.S.; Oelkers, P.: Characterization of human lysophospholipid acyltransferase 3. J. Lipid Res. (2009) 50, 1563-1570. {Pubmed:19351971} AAP 12/7/2011 1111 2200002126 Christie Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/K0.5 #22# 0.0465 {oleoyl-CoA} (#22# 28°C, cooperativity: Hill number 2.0 <64>) <64> 0.0465 mM oleoyl-CoA CHEBI:15534 2.3.1.23 #22# 28°C, cooperativity: Hill number 2.0 <64> Y Y ECO:0000006 Pubmed:19351971 BRENDA <64> Jain, S.; Zhang, X.; Khandelwal, P.J.; Saunders, A.J.; Cummings, B.S.; Oelkers, P.: Characterization of human lysophospholipid acyltransferase 3. J. Lipid Res. (2009) 50, 1563-1570. {Pubmed:19351971} AAP 12/7/2011 1111 2200002127 Christie Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/K0.5 #22# 0.0021 {stearoyl-CoA} (#22# 37°C, cooperativity: Hill number 3.7 <64>) <64> 0.0021 mM stearoyl-CoA CHEBI:15541 2.3.1.23 #22# 37°C, cooperativity: Hill number 3.7 <64> Y Y ECO:0000006 Pubmed:19351971 BRENDA <64> Jain, S.; Zhang, X.; Khandelwal, P.J.; Saunders, A.J.; Cummings, B.S.; Oelkers, P.: Characterization of human lysophospholipid acyltransferase 3. J. Lipid Res. (2009) 50, 1563-1570. {Pubmed:19351971} AAP 12/7/2011 1111 2200002128 Christie Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/K0.5 #22# 0.0051 {stearoyl-CoA} (#22# 28°C, cooperativity: Hill number 2.7 <64>) <64> 0.0051 mM stearoyl-CoA CHEBI:15541 2.3.1.23 #22# 28°C, cooperativity: Hill number 2.7 <64> Y Y ECO:0000006 Pubmed:19351971 BRENDA <64> Jain, S.; Zhang, X.; Khandelwal, P.J.; Saunders, A.J.; Cummings, B.S.; Oelkers, P.: Characterization of human lysophospholipid acyltransferase 3. J. Lipid Res. (2009) 50, 1563-1570. {Pubmed:19351971} AAP 12/7/2011 1111 2200002129 Christie Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/K0.5 #22# 0.232 {stearoyl-CoA} (#22# 37°C, cooperativity: Hill number 1.4 <64>) <64> 0.232 mM stearoyl-CoA CHEBI:15541 2.3.1.23 #22# 37°C, cooperativity: Hill number 1.4 <64> Y Y ECO:0000006 Pubmed:19351971 BRENDA <64> Jain, S.; Zhang, X.; Khandelwal, P.J.; Saunders, A.J.; Cummings, B.S.; Oelkers, P.: Characterization of human lysophospholipid acyltransferase 3. J. Lipid Res. (2009) 50, 1563-1570. {Pubmed:19351971} AAP 12/7/2011 1111 2200002130 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.022 {O2} (#2# with linoleic acid as substrate, in 25 mM Hepes buffer, pH 7.5, 25°C, in the presence of 12(S)-hydroperoxyeicosatetraenoic acid <103>) <103> 0.022 mM dioxygen CHEBI:15379 linoleic acid CHEBI:17351 1.13.11.33 #2# with linoleic acid as substrate, in 25 mM Hepes buffer, pH 7.5, 25°C, in the presence of 12(S)-hydroperoxyeicosatetraenoic acid <103> Y Y ECO:0000006 Pubmed:19469483 BRENDA <103> Wecksler, A.T.; Jacquot, C.; van der Donk, W.A.; Holman, T.R.: Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. Biochemistry (2009) 48, 6259-6267. {Pubmed:19469483}; PENTACON Notes: Km is the concentration of oxygen consumed in the reaction, AA is the substrate AAP, DGA, ASD 12/7/2011 1111 2200002131 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.024 {O2} (#2# with arachidonic acid as substrate, in 25 mM Hepes buffer, pH 7.5, 25°C <103>) <103> 0.024 mM dioxygen CHEBI:15379 arachidonic acid CHEBI:15843 1.13.11.33 #2# with arachidonic acid as substrate, in 25 mM Hepes buffer, pH 7.5, 25°C <103> Y Y ECO:0000006 Pubmed:19469483 BRENDA <103> Wecksler, A.T.; Jacquot, C.; van der Donk, W.A.; Holman, T.R.: Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. Biochemistry (2009) 48, 6259-6267. {Pubmed:19469483}; PENTACON Notes: Km is the concentration of oxygen consumed in the reaction, AA is the substrate AAP, DGA, ASD 12/7/2011 1111 2200002132 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0096 {O2} (#2# with linoleic acid as substrate, in 25 mM Hepes buffer, pH 7.5, 25°C <103>) <103> 0.0096 mM dioxygen CHEBI:15379 linoleic acid CHEBI:17351 1.13.11.33 #2# with linoleic acid as substrate, in 25 mM Hepes buffer, pH 7.5, 25°C <103> Y Y ECO:0000006 Pubmed:19469483 BRENDA <103> Wecksler, A.T.; Jacquot, C.; van der Donk, W.A.; Holman, T.R.: Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. Biochemistry (2009) 48, 6259-6267. {Pubmed:19469483}; PENTACON Notes: Km is the concentration of oxygen consumed in the reaction, AA is the substrate AAP, DGA, ASD 12/7/2011 1111 2200002133 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.015 {O2} (#2# with arachidonic acid as substrate, in 25 mM Hepes buffer, pH 7.5, 25°C, in the presence of 12(S)-hydroperoxyeicosatetraenoic acid <103>) <103> 0.015 mM dioxygen CHEBI:15379 arachidonic acid CHEBI:15843 1.13.11.33 #2# with arachidonic acid as substrate, in 25 mM Hepes buffer, pH 7.5, 25°C, in the presence of 12(S)-hydroperoxyeicosatetraenoic acid <103> Y Y ECO:0000006 Pubmed:19469483 BRENDA <103> Wecksler, A.T.; Jacquot, C.; van der Donk, W.A.; Holman, T.R.: Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid. Biochemistry (2009) 48, 6259-6267. {Pubmed:19469483}; PENTACON Notes: Km is the concentration of oxygen consumed in the reaction, AA is the substrate AAP, DGA, ASD 12/7/2011 1111 2200002134 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6,7# 1.09 {L-Glu-3-carboxy-4-nitroanilide} (#7# L-Cys-Gly, rat kidney enzyme <34>) <1,34> 1.09 mM L-Glu-3-carboxy-4-nitroanilide CHEBI:NONE_148559 2.3.2.2 #7# L-Cys-Gly, rat kidney enzyme <34> Y Y ECO:0000006 Pubmed:1978610 BRENDA <1> Yoshida, K.I.; Arai, K.; Kobayashi, N.; Saitoh, H.: Purification and properties of gamma-glutamyl transpeptidase from human testis. Andrologia (1990) 22, 239-246. {Pubmed:}; PENTACON Notes: Request ChEBI ID: gamma-glutamyl-3-carboxy-4-nitroanilide: CID 104545; Not a rat kidney enzyme as indicated in Secondary Source Notes, but a GGT isolated from human testis, results consistent with GGT1 AAP, DGA, ASD 12/7/2011 1111 2200002135 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.093 {arachidonic acid} <14> 0.093 nmol/min/mg arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:2459258 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200002136 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.077 {Linoleic acid} <14> 0.077 nmol/min/mg linoleic acid CHEBI:17351 Y Y ECO:0000006 Pubmed:2459258 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200002137 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0106 {arachidonic acid} <14> 0.0106 mM arachidonic acid CHEBI:15843 1.13.11.33 Y Y ECO:0000006 Pubmed:2459258 BRENDA <14> Burrall, B.A.; Cheung, M.; Chiu, A.; Goetzel, E.J.: Enzymatic properties of the 15-lipoxygenase of human cultured keratinocytes. J. Invest. Dermatol. (1988) 91, 294-297. {Pubmed:2459258} (c) AAP, DGA, ASD 12/7/2011 1111 2200002138 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0095 {Linoleic acid} <14> 0.0095 mM linoleic acid CHEBI:17351 1.13.11.33 Y Y ECO:0000006 Pubmed:2459258 BRENDA <14> Burrall, B.A.; Cheung, M.; Chiu, A.; Goetzel, E.J.: Enzymatic properties of the 15-lipoxygenase of human cultured keratinocytes. J. Invest. Dermatol. (1988) 91, 294-297. {Pubmed:2459258} (c) AAP, DGA, ASD 12/7/2011 1111 2200002139 Jenn P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/IC50 0.0005 {HgCl2} (#4# pH 7.8, 37°C <13>) <13> 0.0005 mM mercury dichloride CHEBI:31823 leukotriene A4 CHEBI:15651 Y Y ECO:0000006 Pubmed:3038871 PENTACON Added by PENTACON; PENTACON Notes: pH 7.8, 37°C AAP, ASD 4/21/2014 3 2200002140 Jenn P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3 {N-ethylmaleimide} (#4# pH 7.8, 37°C <13>) <13> 3.0 mM N-ethylmaleimide CHEBI:44485 leukotriene A4 CHEBI:15651 Y Y ECO:0000006 Pubmed:3038871 PENTACON Added by PENTACON; PENTACON Notes: pH 7.8, 37°C AAP, ASD 4/21/2014 3 2200002141 Jenn P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/IC50 0.0007 {p-chloromercuribenzoic acid} (#4# pH 7.8, 37°C <13>) <13> 0.0007 mM p-chloromercuribenzoic acid CHEBI:28420 leukotriene A4 CHEBI:15651 Y Y ECO:0000006 Pubmed:3038871 PENTACON Added by PENTACON; PENTACON Notes: pH 7.8, 37°C AAP, ASD 4/21/2014 3 2200002142 Jenn P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2000-3000 {leukotriene A4} (#4# pH 7.8, 37°C <13>) <13> nmol/min/mg leukotriene A4 CHEBI:15651 Y Y ECO:0000006 Pubmed:3038871 PENTACON Added by PENTACON; PENTACON Notes: enzyme purified from two different sources; pH 7.8, 37°C AAP, ASD 4/21/2014 3 2200002143 Jenn P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.013-0.014 {leukotriene A4} (#4# pH 7.8, 37°C <13>) <13> mM leukotriene A4 CHEBI:15651 3.3.2.6 #4# pH 7.8, 37°C <13> Y Y ECO:0000006 Pubmed:3038871 BRENDA <13> Ohishi, N.; Izumi, T.; Minami, M.; Kitamura, S.; Seyama, Y.; Ohkawa, S.; Terao, S.; Yotsumoto, H.; Takaku, F.; Shimizu, T.: Leukotriene A4 hydrolase in the human lung. Inactivation of the enzyme with leukotriene A4 isomers. J. Biol. Chem. (1987) 262, 10200-10205. {Pubmed:3038871}; PENTACON Notes: enzyme purified from two different sources AAP, ASD 12/7/2011 1111 2200002144 Jodi P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.063 {arachidonic acid} 0.063 mM arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:3070300 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200002145 Jodi P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.077 {linoleic acid} 0.077 mM linoleic acid CHEBI:17351 Y Y ECO:0000006 Pubmed:3070300 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200002146 Jodi P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.012 {arachidonic acid} <15> 0.012 mM arachidonic acid CHEBI:15843 ATP CHEBI:15422 1.13.11.34 Y Y ECO:0000006 Pubmed:3070300 BRENDA <15> Soberman, R.J.: 5- and 15(omega-6)-lipoxygenases from human polymorphonuclear leukocytes. Methods Enzymol. (1988) 163, 344-349. {Pubmed:3070300} (c) AAP, DGA, AAP-M, ASD 12/7/2011 1111 2200002147 Christie/Chandra P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.055 {cis-2-methylstyrene oxide} (#6# cytosolic enzyme <12>) <12> 0.055 mM cis-2-methylstyrene oxide CHEBI:NONE_148560 3.3.2.10 #6# cytosolic enzyme <12> Y Y ECO:0000006 Pubmed:3169021 BRENDA <12> Schladt, L.; Thomas, H.; Hartmann, R.; Oesch, F.: Human liver cytosolic epoxide hydrolases. Eur. J. Biochem. (1988) 176, 715-723. {Pubmed:3169021} (c); PENTACON Notes: Request ChEBI ID:cis-2-methylstyrene oxide AAP, DGA, ASD 12/7/2011 1111 2200002148 Christie/Chandra P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.089 {cis-1,2-dimethylstyrene oxide} (#6# cytosolic enzyme <12>) <12> 0.089 mM cis-1,2-dimethylstyrene oxide CHEBI:NONE_148561 3.3.2.10 #6# cytosolic enzyme <12> Y Y ECO:0000006 Pubmed:3169021 BRENDA <12> Schladt, L.; Thomas, H.; Hartmann, R.; Oesch, F.: Human liver cytosolic epoxide hydrolases. Eur. J. Biochem. (1988) 176, 715-723. {Pubmed:3169021} (c); PENTACON Notes: Request ChEBI ID:cis-1,2-dimethylstyrene oxide AAP, DGA, ASD 12/7/2011 1111 2200002149 Christie/Chandra P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.358 {2,2-dimethylstyrene oxide} (#6# cytosolic enzyme <12>) <12> 0.358 mM 2,2-dimethylstyrene oxide CHEBI:NONE_148562 3.3.2.10 #6# cytosolic enzyme <12> Y Y ECO:0000006 Pubmed:3169021 BRENDA <12> Schladt, L.; Thomas, H.; Hartmann, R.; Oesch, F.: Human liver cytosolic epoxide hydrolases. Eur. J. Biochem. (1988) 176, 715-723. {Pubmed:3169021} (c) AAP, DGA, ASD 12/7/2011 1111 2200002150 Christie/Chandra P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 0.517 {7,8-styrene oxide} (#6# cytosolic enzyme <12>) <12> 0.517 mM styrene oxide CHEBI:17907 3.3.2.10 #6# cytosolic enzyme <12> Y Y ECO:0000006 Pubmed:3169021 BRENDA <12> Schladt, L.; Thomas, H.; Hartmann, R.; Oesch, F.: Human liver cytosolic epoxide hydrolases. Eur. J. Biochem. (1988) 176, 715-723. {Pubmed:3169021} (c) AAP, DGA, ASD 12/7/2011 1111 2200002151 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 8.6 {arachidonic acid} <11> 8.6 nmol/min/mg arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:3337718 PENTACON Added by PENTACON; PENTACON Notes: 33°C, pH 7 AAP, DGA, ASD 4/21/2014 3 2200002152 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.068 {arachidonic acid} <11> 0.068 mM arachidonic acid CHEBI:15843 1.13.11.33 Y Y ECO:0000006 Pubmed:3337718 BRENDA <11> Sigal, E.; Grunberger, D.; Cashman, J.R.; Craik, C.S.; Caughey, G.H.; Nadel, J.A.: Arachidonate 15-lipoxygenase from human eosinophil-enriched leukocytes: partial purification and properties. Biochem. Biophys. Res. Commun. (1988) 150, 376-383. {Pubmed:3337718} (c); PENTACON Notes: 33°C, pH 7 AAP, DGA, ASD 12/7/2011 1111 2200002153 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.012 {Arachidonic acid} <15> 0.012 mM arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: ALOX5 prepared from single cell donor AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002154 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1.72 {Arachidonic acid} <15> 1.72 nmol/min/mg arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: ALOX5 prepared from single cell donor AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002155 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.023 {EPA} <15> 0.023 mM icosapentaenoic acid CHEBI:36006 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: ALOX5 prepared from single cell donor AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002156 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 5.5 {EPA} <15> 5.5 nmol/min/mg icosapentaenoic acid CHEBI:36006 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: ALOX5 prepared from single cell donor AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002157 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.0175 {Arachidonic acid} <15> 0.0175 mM arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: ALOX5 prepared from multiple cell donors; pH 7.5 AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002158 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 5.6 {Arachidonic acid} <15> 5.6 nmol/min/mg arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: ALOX5 prepared from multiple cell donors; pH 7.5 AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002159 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.0122 {Arachidonic acid} <15> 0.0122 mM arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: ALOX5 prepared from multiple cell donors AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002160 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2.8 {Arachidonic acid} <15> 2.8 nmol/min/mg arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: ALOX5 prepared from multiple cell donors AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002161 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.025 {EPA} <15> 0.025 mM icosapentaenoic acid CHEBI:36006 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: ALOX5 prepared from multiple cell donors AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002162 Jenn P09917 240 ALOX5 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 5 {EPA} <15> 5.0 nmol/min/mg icosapentaenoic acid CHEBI:36006 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: ALOX5 prepared from multiple cell donors AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002163 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 5.3 {arachidonic acid} <15> 5.3 nmol/min/mg arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: 22°C, pH 7.5. ALOX15 prepared from multiple cell donors AAP, DGA, ASD 4/21/2014 3 2200002164 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 9.5 {Linoleic acid} <15> 9.5 nmol/min/mg linoleic acid CHEBI:17351 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: 22°C, pH 7.5. ALOX15 prepared from multiple cell donors AAP, DGA, ASD 4/21/2014 3 2200002165 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 10 {Linoleic acid} <15> 10.0 nmol/min/mg linoleic acid CHEBI:17351 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: 22°C, pH 7.5. ALOX15 prepared from multiple cell donors AAP, DGA, ASD 4/21/2014 3 2200002166 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0634 {arachidonic acid} <15> 0.0634 mM arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: 22°C, pH 7.5. ALOX15 prepared from a single cell donor AAP, DGA, ASD 4/21/2014 3 2200002167 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.083 {Linoleic acid} <15> 0.083 mM linoleic acid CHEBI:17351 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: 22°C, pH 7.5. ALOX15 prepared from a single cell donor AAP, DGA, ASD 4/21/2014 3 2200002168 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0571 {arachidonic acid} <15> 0.0571 mM arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: 22°C, pH 6.5. ALOX15 prepared from a single cell donor AAP, DGA, ASD 4/21/2014 3 2200002169 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 11.3 {arachidonic acid} <15> 11.3 nmol/min/mg arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: 22°C, pH 6.5. ALOX15 prepared from a single cell donor AAP, DGA, ASD 4/21/2014 3 2200002170 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0725 {Linoleic acid} <15> 0.0725 mM linoleic acid CHEBI:17351 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: 22°C, pH 6.5. ALOX15 prepared from a single cell donor AAP, DGA, ASD 4/21/2014 3 2200002171 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 30.8 {Linoleic acid} <15> 30.8 nmol/min/mg linoleic acid CHEBI:17351 Y Y ECO:0000006 Pubmed:3920219 PENTACON Added by PENTACON; PENTACON Notes: 22°C, pH 6.5. ALOX15 prepared from a single cell donor AAP, DGA, ASD 4/21/2014 3 2200002172 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0631 {arachidonic acid} <15> 0.0631 mM arachidonic acid CHEBI:15843 1.13.11.33 Y Y ECO:0000006 Pubmed:3920219 BRENDA <15> Soberman, R.J.; Harper, T.W.; Betteridge, D.; Lewis, R.A.; Austen, K.F.: Characterization and separation of the arachidonic acid 5-lipoxygenase and linoleic acid omega-6 lipoxygenase (arachidonic acid 15-lipoxygenase) of human polymorphonuclear leukocytes. J. Biol. Chem. (1985) 260, 4508-4515. {Pubmed:3920219} (c); PENTACON Notes: 22°C, pH 7.5. ALOX15 prepared from multiple cell donors AAP, DGA, ASD 12/7/2011 1111 2200002173 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.0772 {Linoleic acid} <15> 0.0772 mM linoleic acid CHEBI:17351 1.13.11.33 Y Y ECO:0000006 Pubmed:3920219 BRENDA <15> Soberman, R.J.; Harper, T.W.; Betteridge, D.; Lewis, R.A.; Austen, K.F.: Characterization and separation of the arachidonic acid 5-lipoxygenase and linoleic acid omega-6 lipoxygenase (arachidonic acid 15-lipoxygenase) of human polymorphonuclear leukocytes. J. Biol. Chem. (1985) 260, 4508-4515. {Pubmed:3920219} (c); PENTACON Notes: 22°C, pH 7.5. ALOX15 prepared from multiple cell donors AAP, DGA, ASD 12/7/2011 1111 2200002174 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.8 mM {gamma-glutamyl-p-nitroanilide} in the presence of glycylglycine (gamma-glutamyl acceptor); purified from kidney 0.8 mM gamma-L-Glutamyl-p-nitroanilide CHEBI:NONE_148541 glycylglycine CHEBI:17201 Y Y ECO:0000006 Pubmed:4442 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: gamma-L-Glutamyl-p-nitroanilide: CID 16219428 AAP, DGA, ASD 4/21/2014 3 2200002175 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.033 {Prostaglandin A1} <16> 0.033 mM prostaglandin A1 CHEBI:15545 1.1.1.141 Y Y ECO:0000006 Pubmed:4822191 BRENDA <16> Schlegel, W.; Demers, L.M.; Hildebrandt-Stark, H.E.; Behrman, H.R.; Greep, R.O.: Partial purification of human placental 15-hydroxy-prostaglandin dehydrogenase: kinetic properties. Prostaglandins (1974) 5, 417-433. {Pubmed:4822191} AAP, ASD 12/7/2011 1111 2200002176 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.032 {Prostaglandin A2} <16> 0.032 mM prostaglandin A2 CHEBI:27820 1.1.1.141 Y Y ECO:0000006 Pubmed:4822191 BRENDA <16> Schlegel, W.; Demers, L.M.; Hildebrandt-Stark, H.E.; Behrman, H.R.; Greep, R.O.: Partial purification of human placental 15-hydroxy-prostaglandin dehydrogenase: kinetic properties. Prostaglandins (1974) 5, 417-433. {Pubmed:4822191} AAP, ASD 12/7/2011 1111 2200002177 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.027 {prostaglandin E1} <16> 0.027 mM prostaglandin E1 CHEBI:15544 1.1.1.141 Y Y ECO:0000006 Pubmed:4822191 BRENDA <16> Schlegel, W.; Demers, L.M.; Hildebrandt-Stark, H.E.; Behrman, H.R.; Greep, R.O.: Partial purification of human placental 15-hydroxy-prostaglandin dehydrogenase: kinetic properties. Prostaglandins (1974) 5, 417-433. {Pubmed:4822191} AAP, ASD 12/7/2011 1111 2200002178 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.01 {prostaglandin E2} <16,24> 0.01 mM prostaglandin E2 CHEBI:15551 1.1.1.141 Y Y ECO:0000006 Pubmed:4822191 BRENDA <16> Schlegel, W.; Demers, L.M.; Hildebrandt-Stark, H.E.; Behrman, H.R.; Greep, R.O.: Partial purification of human placental 15-hydroxy-prostaglandin dehydrogenase: kinetic properties. Prostaglandins (1974) 5, 417-433. {Pubmed:4822191} AAP, ASD 12/7/2011 1111 2200002179 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.059 {prostaglandin F2alpha} <16> 0.059 mM prostaglandin F2alpha CHEBI:15553 1.1.1.141 Y Y ECO:0000006 Pubmed:4822191 BRENDA <16> Schlegel, W.; Demers, L.M.; Hildebrandt-Stark, H.E.; Behrman, H.R.; Greep, R.O.: Partial purification of human placental 15-hydroxy-prostaglandin dehydrogenase: kinetic properties. Prostaglandins (1974) 5, 417-433. {Pubmed:4822191} AAP, ASD 12/7/2011 1111 2200002180 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1700 {leukotriene B4} 1700.0 nmol/min/mg leukotriene B4 CHEBI:15647 Y Y ECO:0000006 Pubmed:6490615 PENTACON Added by PENTACON; PENTACON Notes: 37°C AAP, ASD 4/21/2014 3 2200002181 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1100 {leukotriene B4} 1100.0 nmol/min/mg leukotriene B4 CHEBI:15647 Y Y ECO:0000006 Pubmed:6490615 PENTACON Added by PENTACON; PENTACON Notes: 2°C AAP, ASD 4/21/2014 3 2200002182 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.022 {leukotriene A4} (#4# pH 7.7-8.0, 2°C <7>) <7> 0.022 mM leukotriene A4 CHEBI:15651 3.3.2.6 #4# pH 7.7-8.0, 2°C <7> Y Y ECO:0000006 Pubmed:6490615 BRENDA <7> Radmark, O.; Shimizu, T.; Jornvall, H.; Samuelsson, B.: Leukotriene A4 hydrolase in human leukocytes. Purification and properties. J. Biol. Chem. (1984) 259, 12339-12345. {Pubmed:6490615} AAP, ASD 12/7/2011 1111 2200002183 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.023 {leukotriene A4} (#4# pH 7.7-8.0, 37°C <7>; #4# pH 8.0, 22°C, mutant Y378F <28,29>) <7,28,29> 0.023 mM leukotriene A4 CHEBI:15651 3.3.2.6 #4# pH 7.7-8.0, 37°C <7>; #4# pH 8.0, 22°C, mutant Y378F <28,29> Y Y ECO:0000006 Pubmed:6490615 BRENDA <7> Radmark, O.; Shimizu, T.; Jornvall, H.; Samuelsson, B.: Leukotriene A4 hydrolase in human leukocytes. Purification and properties. J. Biol. Chem. (1984) 259, 12339-12345. {Pubmed:6490615} AAP, ASD 12/7/2011 1111 2200002184 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4,5# 0.02-0.03 {leukotriene A4} (#4,5# pH 7.7-7.8, 37°C <1,7>) <1,7> mM leukotriene A4 CHEBI:15651 3.3.2.6 #4,5# pH 7.7-7.8, 37°C <1,7> Y Y ECO:0000006 Pubmed:6490615 BRENDA <7> Radmark, O.; Shimizu, T.; Jornvall, H.; Samuelsson, B.: Leukotriene A4 hydrolase in human leukocytes. Purification and properties. J. Biol. Chem. (1984) 259, 12339-12345. {Pubmed:6490615} AAP, ASD 12/7/2011 1111 2200002185 Christie P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.024 {5,8,11,14,17-eicosapentaenoic acid} <22> 0.024 mM 5,8,11,14,17-eicosapentaenoic acid CHEBI:NONE_148563 1.13.11.31 Y Y ECO:0000006 Pubmed:6783111 BRENDA <22> Wallach, D.P.; Brown, V.R.: A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases. Biochim. Biophys. Acta (1981) 663, 361-372. {Pubmed:6783111} (c); PENTACON Notes: Request ChEBI ID: 5,8,11,14,17-eicosapentaenoic acid; Pubchem ID: CID 3209 AAP, DGA, AAP-M 12/7/2011 1111 2200002186 Christie P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.079 {8,11,14-Eicosatrienoic acid} <22> 0.079 mM all-cis-icosa-8,11,14-trienoic acid CHEBI:53486 1.13.11.31 Y Y ECO:0000006 Pubmed:6783111 BRENDA <22> Wallach, D.P.; Brown, V.R.: A novel preparation of human platelet lipoxygenase. Characteristics and inhibition by a variety of phenyl hydrazones and comparisons with other lipoxygenases. Biochim. Biophys. Acta (1981) 663, 361-372. {Pubmed:6783111} (c) AAP, DGA, AAP-M 12/7/2011 1111 2200002187 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0013 {prostaglandin E1} (#4# at pH 7.0 <5>) <5,12> 0.0013 mM prostaglandin E1 CHEBI:15544 1.1.1.141 #4# at pH 7.0 <5> Y Y ECO:0000033 Pubmed:7132749 BRENDA <12> Jabarak, J.: Isolation and properties of an NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from human placenta. Methods Enzymol. (1982) 86, 126-130. {Pubmed:7132749} (review) AAP, ASD 12/7/2011 1111 2200002188 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0048 {prostaglandin E1} (#4# at pH 9.0 <5>) <5,12> 0.0048 mM prostaglandin E1 CHEBI:15544 1.1.1.141 #4# at pH 9.0 <5> Y Y ECO:0000033 Pubmed:7132749 BRENDA <12> Jabarak, J.: Isolation and properties of an NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from human placenta. Methods Enzymol. (1982) 86, 126-130. {Pubmed:7132749} (review) AAP, ASD 12/7/2011 1111 2200002189 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 3000 {Phosphatidylcholine} recombinant enzyme <19> 3000.0 nmol/min/mg phosphatidylcholine CHEBI:49183 Y Y ECO:0000006 Pubmed:7798190 PENTACON Added by PENTACON; PENTACON Notes: recombinant enzyme AAP, DGA, ASD 4/21/2014 3 2200002190 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 70000 {Phosphatidylethanolamine} ) recombinant enzyme 70000.0 nmol/min/mg phosphatidylethanolamine CHEBI:16038 Y Y ECO:0000006 Pubmed:7798190 PENTACON Added by PENTACON; PENTACON Notes: recombinant enzyme AAP, DGA, ASD 4/21/2014 3 2200002191 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 6300 {Phosphatidylcholine} (#8# natural PLA2 <19>) <19> 6300.0 nmol/min/mg phosphatidylcholine CHEBI:49183 Y Y ECO:0000006 Pubmed:7798190 PENTACON Added by PENTACON; PENTACON Notes: natural PLA2 AAP, DGA, ASD 4/21/2014 3 2200002192 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 145000 {Phosphatidylethanolamine} (#8# natural PLA2 <19>) <19> 145000.0 nmol/min/mg phosphatidylethanolamine CHEBI:16038 Y Y ECO:0000006 Pubmed:7798190 PENTACON Added by PENTACON; PENTACON Notes: natural PLA2 AAP, DGA, ASD 4/21/2014 3 2200002193 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/KM #8# 0.05 {Phosphatidylcholine} (#8# recombinant PLA2 <19>) <19> 0.05 mM phosphatidylcholine CHEBI:49183 3.1.1.4 #8# recombinant PLA2 <19> Y Y ECO:0000006 Pubmed:7798190 BRENDA <19> Kawauchi, Y.; Takasaki, J.; Matsuura, Y.; Masuho, Y.: Preparation and characterization of human rheumatoid arthritic synovial fluid phospholipase A2 produced by recombinant baculovirus-infected cells. J. Biochem. (1994) 116, 82-87. {Pubmed:} AAP, DGA, ASD 12/7/2011 1111 2200002194 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/KM #8# 0.051 {Phosphatidylcholine} (#8# natural PLA2 <19>) <19> 0.051 mM phosphatidylcholine CHEBI:49183 3.1.1.4 #8# natural PLA2 <19> Y Y ECO:0000006 Pubmed:7798190 BRENDA <19> Kawauchi, Y.; Takasaki, J.; Matsuura, Y.; Masuho, Y.: Preparation and characterization of human rheumatoid arthritic synovial fluid phospholipase A2 produced by recombinant baculovirus-infected cells. J. Biochem. (1994) 116, 82-87. {Pubmed:} AAP, DGA, ASD 12/7/2011 1111 2200002195 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/KM #8# 0.02 {Phosphatidylethanolamine} (#8# recombinant PLA2 <19>) <19> 0.02 mM phosphatidylethanolamine CHEBI:16038 3.1.1.4 #8# recombinant PLA2 <19> Y Y ECO:0000006 Pubmed:7798190 BRENDA <19> Kawauchi, Y.; Takasaki, J.; Matsuura, Y.; Masuho, Y.: Preparation and characterization of human rheumatoid arthritic synovial fluid phospholipase A2 produced by recombinant baculovirus-infected cells. J. Biochem. (1994) 116, 82-87. {Pubmed:} AAP, DGA, ASD 12/7/2011 1111 2200002196 Jenn P14555 5320 PLA2G2A Homo sapiens 9606 Comment/biophysicochemical properties/KM #8# 0.024 {Phosphatidylethanolamine} (#8# natural PLA2 <19>) <19> 0.024 mM phosphatidylethanolamine CHEBI:16038 3.1.1.4 #8# natural PLA2 <19> Y Y ECO:0000006 Pubmed:7798190 BRENDA <19> Kawauchi, Y.; Takasaki, J.; Matsuura, Y.; Masuho, Y.: Preparation and characterization of human rheumatoid arthritic synovial fluid phospholipase A2 produced by recombinant baculovirus-infected cells. J. Biochem. (1994) 116, 82-87. {Pubmed:} AAP, DGA, ASD 12/7/2011 1111 2200002197 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax WT Vmax 640.0 umol/min/mg L-Glutamic acid gamma-(4-nitroanilide) CHEBI:NONE_148551 glycylglycine CHEBI:17201 Y Y ECO:0000006 Pubmed:7816801 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: L-Glutamic acid gamma-(4-nitroanilide): CID 57369855 AAP, DGA, ASD 4/21/2014 3 2200002198 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax WT Vmax 1100.0 umol/min/mg L-Glutamic acid gamma-(4-nitroanilide) CHEBI:NONE_148551 glycylglycine CHEBI:17201 Y Y ECO:0000006 Pubmed:7816801 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: L-Glutamic acid gamma-(4-nitroanilide): CID 57369855 AAP, DGA, ASD 4/21/2014 3 2200002199 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 3.4 {Glycylglycine} (#6# recombinant mutant enzyme <65>) <65> 3.4 mM glycylglycine CHEBI:17201 L-Glutamic acid gamma-(4-nitroanilide) CHEBI:NONE_148551 2.3.2.2 #6# recombinant mutant enzyme <65> Y Y ECO:0000006 Pubmed:7816801 BRENDA <65> Ikeda, Y.; Fujii, J.; Taniguchi, N.; Meister, A.: Expression of an active glycosylated human gamma-glutamyl transpeptidase mutant that lacks a membrane anchor domain. Proc. Natl. Acad. Sci. USA (1995) 92, 126-130. {Pubmed:7816801}; PENTACON Notes: Request ChEBI ID: L-Glutamic acid gamma-(4-nitroanilide): CID 57369855; Mutant:deltaSign AAP, DGA, ASD 12/7/2011 1111 2200002200 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6,21# 2.1 {L-Glu-4-nitroanilide} (#21# isoform II, hydrolase reaction <71>; #6# recombinant mutant enzyme <65>) <65,71> 2.1 mM L-Glutamic acid gamma-(4-nitroanilide) CHEBI:NONE_148551 glycylglycine CHEBI:17201 2.3.2.2 #21# isoform II, hydrolase reaction <71>; #6# recombinant mutant enzyme <65> Y Y ECO:0000006 Pubmed:7816801 BRENDA <65> Ikeda, Y.; Fujii, J.; Taniguchi, N.; Meister, A.: Expression of an active glycosylated human gamma-glutamyl transpeptidase mutant that lacks a membrane anchor domain. Proc. Natl. Acad. Sci. USA (1995) 92, 126-130. {Pubmed:7816801}; PENTACON Notes: Request ChEBI ID: L-Glutamic acid gamma-(4-nitroanilide): CID 57369855; Mutant:deltaSign AAP, DGA, ASD 12/7/2011 1111 2200002201 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6,7,17# 2.9-2.96 {Glycylglycine} (#6# recombinant wild-type enzyme <65>; #7# rat kidney enzyme <34>) <34,50,65> 2.9 mM glycylglycine CHEBI:17201 L-Glutamic acid gamma-(4-nitroanilide) CHEBI:NONE_148551 2.3.2.2 #6# recombinant wild-type enzyme <65>; #7# rat kidney enzyme <34> Y Y ECO:0000006 Pubmed:7816801 BRENDA <65> Ikeda, Y.; Fujii, J.; Taniguchi, N.; Meister, A.: Expression of an active glycosylated human gamma-glutamyl transpeptidase mutant that lacks a membrane anchor domain. Proc. Natl. Acad. Sci. USA (1995) 92, 126-130. {Pubmed:7816801}; PENTACON Notes: Request ChEBI ID: L-Glutamic acid gamma-(4-nitroanilide): CID 57369855; Human protein, not from rat kidney as indicated in Secondary Source notes. AAP, DGA, ASD 12/7/2011 1111 2200002202 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.5 {L-Glu-4-nitroanilide} (#6# recombinant wild-type <65>; #6# bile enzyme <46>) <46,65> 1.5 mM L-Glutamic acid gamma-(4-nitroanilide) CHEBI:NONE_148551 glycylglycine CHEBI:17201 2.3.2.2 #6# recombinant wild-type <65>; #6# bile enzyme <46> Y Y ECO:0000006 Pubmed:7816801 BRENDA <65> Ikeda, Y.; Fujii, J.; Taniguchi, N.; Meister, A.: Expression of an active glycosylated human gamma-glutamyl transpeptidase mutant that lacks a membrane anchor domain. Proc. Natl. Acad. Sci. USA (1995) 92, 126-130. {Pubmed:7816801}; PENTACON Notes: Request ChEBI ID: L-Glutamic acid gamma-(4-nitroanilide): CID 57369855 AAP, DGA, ASD 12/7/2011 1111 2200002203 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 406 {alanine-4-nitroanilide} 406.0 nmol/min/mg alanine-4-nitroanilide CHEBI:NONE_148529 Y Y ECO:0000006 Pubmed:7893649 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: alanine-4-nitroanilide; Pubchem ID: CID 150936 AAP, ASD 4/21/2014 3 2200002204 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1439 {alanine-4-nitroanilide} 1439.0 nmol/min/mg alanine-4-nitroanilide CHEBI:NONE_148529 Y Y ECO:0000006 Pubmed:7893649 PENTACON Added by PENTACON; PENTACON Notes: LTA4H modified with methyl methanethiosulfonate; Request ChEBI ID: alanine-4-nitroanilide; Pubchem ID: CID 150936 AAP, ASD 4/21/2014 3 2200002205 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.47 {alanine-4-nitroanilide} (#4# pH 7.5, 25°C <27>) <27> 0.47 mM alanine-4-nitroanilide CHEBI:NONE_148529 3.3.2.6 #4# pH 7.5, 25°C <27> Y Y ECO:0000006 Pubmed:7893649 BRENDA <27> Mueller, M.J.; Samuelsson, B.; Haeggstrom, J.Z.: Chemical modification of leukotriene A4 hydrolase. Indications for essential tyrosyl and arginyl residues at the active site. Biochemistry (1995) 34, 3536-3543. {Pubmed:7893649}; PENTACON Notes: Request ChEBI ID: alanine-4-nitroanilide; Pubchem ID: CID 150936 AAP, ASD 12/7/2011 1111 2200002206 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 15480 {6-keto prostaglandin F1alpha} 15480.0 nmol/min/mg 6-oxo-prostaglandin F1alpha CHEBI:28158 Y Y ECO:0000006 Pubmed:8086429 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200002207 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 24980 {NAD+} 24980.0 nmol/min/mg NAD(+) CHEBI:15846 Y Y ECO:0000006 Pubmed:8086429 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200002208 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 21580 {prostaglandin A1} 21580.0 nmol/min/mg prostaglandin A1 CHEBI:15545 Y Y ECO:0000006 Pubmed:8086429 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200002209 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 13100 {prostaglandin A2} 13100.0 nmol/min/mg prostaglandin A2 CHEBI:27820 Y Y ECO:0000006 Pubmed:8086429 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200002210 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 22800 {prostaglandin E1} 22800.0 nmol/min/mg prostaglandin E1 CHEBI:15544 Y Y ECO:0000006 Pubmed:8086429 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200002211 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 24600 {prostaglandin E2} 24600.0 nmol/min/mg prostaglandin E2 CHEBI:15551 Y Y ECO:0000006 Pubmed:8086429 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200002212 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 22330 {prostaglandin F2alpha} 22330.0 nmol/min/mg prostaglandin F2alpha CHEBI:15553 Y Y ECO:0000006 Pubmed:8086429 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200002213 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.063 {6-ketoprostaglandin F1alpha} (#4# recombinant enzyme expressed in E. coli <26>) <26> 0.063 mM 6-oxo-prostaglandin F1alpha CHEBI:28158 1.1.1.141 #4# recombinant enzyme expressed in E. coli <26> Y Y ECO:0000006 Pubmed:8086429 BRENDA <26> Ensoe, C.M.; Tai, H.H.: Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Biochim. Biophys. Acta (1994) 1208, 151-156. {Pubmed:8086429} AAP, ASD 12/7/2011 1111 2200002214 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.022 {NAD+} (#4# recombinant enzyme expressed in E. coli <26>; #4# 37°C, pH 7.5, V186K mutant <33>) <26,33> 0.022 mM NAD(+) CHEBI:15846 1.1.1.141 #4# recombinant enzyme expressed in E. coli <26>; #4# 37°C, pH 7.5, V186K mutant <33> Y Y ECO:0000006 Pubmed:8086429 BRENDA <26> Ensoe, C.M.; Tai, H.H.: Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Biochim. Biophys. Acta (1994) 1208, 151-156. {Pubmed:8086429} AAP, ASD 12/7/2011 1111 2200002215 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0045 {Prostaglandin A1} (#4# recombinant enzyme expressed in E. coli <26>) <26> 0.0045 mM prostaglandin A1 CHEBI:15545 1.1.1.141 #4# recombinant enzyme expressed in E. coli <26> Y Y ECO:0000006 Pubmed:8086429 BRENDA <26> Ensoe, C.M.; Tai, H.H.: Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Biochim. Biophys. Acta (1994) 1208, 151-156. {Pubmed:8086429} AAP, ASD 12/7/2011 1111 2200002216 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.022 {Prostaglandin A2} (#4# recombinant enzyme expressed in E. coli <26>) <26> 0.022 mM prostaglandin A2 CHEBI:27820 1.1.1.141 #4# recombinant enzyme expressed in E. coli <26> Y Y ECO:0000006 Pubmed:8086429 BRENDA <26> Ensoe, C.M.; Tai, H.H.: Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Biochim. Biophys. Acta (1994) 1208, 151-156. {Pubmed:8086429} AAP, ASD 12/7/2011 1111 2200002217 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0055 {prostaglandin E1} (#4# recombinant enzyme expressed in E. coli <26>) <26> 0.0055 mM prostaglandin E1 CHEBI:15544 1.1.1.141 #4# recombinant enzyme expressed in E. coli <26> Y Y ECO:0000006 Pubmed:8086429 BRENDA <26> Ensoe, C.M.; Tai, H.H.: Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Biochim. Biophys. Acta (1994) 1208, 151-156. {Pubmed:8086429} AAP, ASD 12/7/2011 1111 2200002218 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.0039 {prostaglandin E2} (#4# recombinant enzyme expressed in E. coli <26>) <26> 0.0039 mM prostaglandin E2 CHEBI:15551 1.1.1.141 #4# recombinant enzyme expressed in E. coli <26> Y Y ECO:0000006 Pubmed:8086429 BRENDA <26> Ensoe, C.M.; Tai, H.H.: Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Biochim. Biophys. Acta (1994) 1208, 151-156. {Pubmed:8086429} AAP, ASD 12/7/2011 1111 2200002219 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.04 {prostaglandin F2alpha} (#4# recombinant enzyme expressed in E. coli <26>) <26> 0.04 mM prostaglandin F2alpha CHEBI:15553 1.1.1.141 #4# recombinant enzyme expressed in E. coli <26> Y Y ECO:0000006 Pubmed:8086429 BRENDA <26> Ensoe, C.M.; Tai, H.H.: Bacterial expression and site-directed mutagenesis of two critical residues (tyrosine-151 and lysine-155) of human placental NAD+-dependent 15-hydroxyprostaglandin dehydrogenase. Biochim. Biophys. Acta (1994) 1208, 151-156. {Pubmed:8086429} AAP, ASD 12/7/2011 1111 2200002220 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 5600 {arachidonic acid} <26> 5600.0 nmol/min/mg arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:8334154 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200002221 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 10600 {Linoleic acid} <26> 10600.0 nmol/min/mg linoleic acid CHEBI:17351 Y Y ECO:0000006 Pubmed:8334154 PENTACON Added by PENTACON AAP, DGA, ASD 4/21/2014 3 2200002222 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.012 {arachidonic acid} <26> 0.012 mM arachidonic acid CHEBI:15843 1.13.11.33 Y Y ECO:0000006 Pubmed:8334154 BRENDA <26> Kuehn, H.; Barnett, J.; Grunberger, D.; Baecker, P.; Chow, J.; Nguyen, B.; Bursztyn-Pettegrew, H.; Chan, H.; Sigal, E.: Overexpression, purification and characterization of human recombinant 15-lipoxygenase. Biochim. Biophys. Acta (1993) 1169, 80-89. {Pubmed:8334154} (c) AAP, DGA, ASD 12/7/2011 1111 2200002223 Jenn P16050 246 ALOX15 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.003 {Linoleic acid} <26> 0.003 mM linoleic acid CHEBI:17351 1.13.11.33 Y Y ECO:0000006 Pubmed:8334154 BRENDA <26> Kuehn, H.; Barnett, J.; Grunberger, D.; Baecker, P.; Chow, J.; Nguyen, B.; Bursztyn-Pettegrew, H.; Chan, H.; Sigal, E.: Overexpression, purification and characterization of human recombinant 15-lipoxygenase. Biochim. Biophys. Acta (1993) 1169, 80-89. {Pubmed:8334154} (c) AAP, DGA, ASD 12/7/2011 1111 2200002224 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM .00968 {(5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid} 0.00968 mM 12-hydroxy-5,8,10-heptadecatrienoic acid CHEBI:NONE_148564 Y Y ECO:0000006 Pubmed:8508808 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID:12-hydroxy-5,8,10-heptadecatrienoic acid; Pubchem ID: CID 5283141 AAP, ASD 4/21/2014 3 2200002225 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM .102 {NAD+} 0.102 mM NAD(+) CHEBI:15846 Y Y ECO:0000006 Pubmed:8508808 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200002226 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.00765 {(5Z,8E,10E,12S)-12-hydroxy-5,8,10-heptadecatrienoic acid} <24> 0.00765 mM 12-hydroxy-5,8,10-heptadecatrienoic acid CHEBI:NONE_148564 1.1.1.141 Y Y ECO:0000006 Pubmed:8508808 BRENDA <24> Hohl, W.; Stahl, B.; Mundkowski, R.; Hofmann, U.; Meese, C.O.; Kuhlmann, U.; Schlegel, W.: Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z,8E,10E,12S)-12-hydroxy-5,8,10,-heptadecatrienoic acid as substrate. Eur. J. Biochem. (1993) 214, 67-73. {Pubmed:8508808}; PENTACON Notes: Request ChEBI ID:12-hydroxy-5,8,10-heptadecatrienoic acid; Pubchem ID: CID 5283141 AAP, ASD 12/7/2011 1111 2200002227 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.117 {NAD+} <24> 0.117 mM NAD(+) CHEBI:15846 1.1.1.141 Y Y ECO:0000006 Pubmed:8508808 BRENDA <24> Hohl, W.; Stahl, B.; Mundkowski, R.; Hofmann, U.; Meese, C.O.; Kuhlmann, U.; Schlegel, W.: Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z,8E,10E,12S)-12-hydroxy-5,8,10,-heptadecatrienoic acid as substrate. Eur. J. Biochem. (1993) 214, 67-73. {Pubmed:8508808} AAP, ASD 12/7/2011 1111 2200002228 Christie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.01 {prostaglandin E2} <16,24> 0.01 mM prostaglandin E2 CHEBI:15551 1.1.1.141 Y Y ECO:0000033 Pubmed:8508808 BRENDA <24> Hohl, W.; Stahl, B.; Mundkowski, R.; Hofmann, U.; Meese, C.O.; Kuhlmann, U.; Schlegel, W.: Mass determination of 15-hydroxyprostaglandin dehydrogenase from human placenta and kinetic studies with (5Z,8E,10E,12S)-12-hydroxy-5,8,10,-heptadecatrienoic acid as substrate. Eur. J. Biochem. (1993) 214, 67-73. {Pubmed:8508808} AAP, ASD 12/7/2011 1111 2200002229 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.023 {leukotriene A4} (#4# pH 7.7-8.0, 37°C <7>; #4# pH 8.0, 22°C, mutant Y378F <28,29>) <7,28,29> 0.023 mM leukotriene A4 CHEBI:15651 3.3.2.6 #4# pH 7.7-8.0, 37°C <7>; #4# pH 8.0, 22°C, mutant Y378F <28,29> Y Y ECO:0000006 Pubmed:8650196 BRENDA <28> Mueller, M.J.; Blomster, M.; Oppermann, U.C.; Jornvall, H.; Samuelsson, B.; Haeggstrom, J.Z.: Leukotriene A4 hydrolase: protection from mechanism-based inactivation by mutation of tyrosine-378. Proc. Natl. Acad. Sci. USA (1996) 93, 5931-5935. {Pubmed:8650196}; PENTACON Notes: Mutant: Y378F AAP, ASD 12/7/2011 1111 2200002230 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.006 {leukotriene A4} (#4# pH 8.0, 22°C, wild-type enzyme <28,29>) <28,29> 0.006 mM leukotriene A4 CHEBI:15651 3.3.2.6 #4# pH 8.0, 22°C, wild-type enzyme <28,29> Y Y ECO:0000006 Pubmed:8650196 BRENDA <28> Mueller, M.J.; Blomster, M.; Oppermann, U.C.; Jornvall, H.; Samuelsson, B.; Haeggstrom, J.Z.: Leukotriene A4 hydrolase: protection from mechanism-based inactivation by mutation of tyrosine-378. Proc. Natl. Acad. Sci. USA (1996) 93, 5931-5935. {Pubmed:8650196} AAP, ASD 12/7/2011 1111 2200002231 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.023 {leukotriene A4} (#4# pH 7.7-8.0, 37°C <7>; #4# pH 8.0, 22°C, mutant Y378F <28,29>) <7,28,29> 0.023 mM leukotriene A4 CHEBI:15651 3.3.2.6 #4# pH 7.7-8.0, 37°C <7>; #4# pH 8.0, 22°C, mutant Y378F <28,29> Y Y ECO:0000006 Pubmed:8798687 BRENDA <29> Mueller, M.J.; Andberg, M.B.; Samuelsson, B.; Haeggstrom, J.Z.: Leukotriene A4 hydrolase, mutation of tyrosine 378 allows conversion of leukotriene A4 into an isomer of leukotriene B4. J. Biol. Chem. (1996) 271, 24345-24348. {Pubmed:8798687}; PENTACON Notes: Mutant: Y378F AAP, ASD 12/7/2011 1111 2200002232 Christie P09960 4048 LTA4H Homo sapiens 9606 Comment/biophysicochemical properties/KM #4# 0.006 {leukotriene A4} (#4# pH 8.0, 22°C, wild-type enzyme <28,29>) <28,29> 0.006 mM leukotriene A4 CHEBI:15651 3.3.2.6 #4# pH 8.0, 22°C, wild-type enzyme <28,29> Y Y ECO:0000006 Pubmed:8798687 BRENDA <29> Mueller, M.J.; Andberg, M.B.; Samuelsson, B.; Haeggstrom, J.Z.: Leukotriene A4 hydrolase, mutation of tyrosine 378 allows conversion of leukotriene A4 into an isomer of leukotriene B4. J. Biol. Chem. (1996) 271, 24345-24348. {Pubmed:8798687} AAP, ASD 12/7/2011 1111 2200002233 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 5.5 5.5 umol/min/mg L-Glutamic acid gamma-(4-nitroanilide) CHEBI:NONE_148551 water CHEBI:15377 Y Y ECO:0000006 Pubmed:8827453 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: L-Glutamic acid gamma-(4-nitroanilide): CID 57369855; hydrolysis reaction AAP, DGA, ASD 4/21/2014 3 2200002234 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1200 1200.0 umol/min/mg L-Glutamic acid gamma-(4-nitroanilide) CHEBI:NONE_148551 glycylglycine CHEBI:17201 Y Y ECO:0000006 Pubmed:8827453 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: L-Glutamic acid gamma-(4-nitroanilide): CID 57369855; transpeptidation AAP, DGA, ASD 4/21/2014 3 2200002235 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 10 10.0 mM glycylglycine CHEBI:17201 L-Glutamic acid gamma-(4-nitroanilide) CHEBI:NONE_148551 Y Y ECO:0000006 Pubmed:8827453 PENTACON Added by PENTACON; PENTACON Notes: recombinant wild-type, transpeptidation AAP, DGA, ASD 4/21/2014 3 2200002236 Chandra P19440 2678 GGT1 Homo sapiens 9606 #6# 0.008 {L-Glu-4-nitroanilide} (#6# hydrolase reaction <67>) <67> 0.008 mM L-Glutamic acid gamma-(4-nitroanilide) CHEBI:NONE_148551 water CHEBI:15377 2.3.2.2 #6# hydrolase reaction <67> Y Y ECO:0000006 Pubmed:8827453 BRENDA <67> Ikeda, Y.; Fujii, J.; Taniguchi, N.: Effects of substitutions of the conserved histidine residues in human gamma-glutamyl transpeptidase. J. Biochem. (1996) 119, 1166-1170. {Pubmed:8827453}; PENTACON Notes: Request ChEBI ID:L-Glutamic acid gamma-(4-nitroanilide): CID 57369855 AAP, DGA, ASD 12/7/2011 1111 2200002237 Chandra P19440 2678 GGT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM #6# 1.4 {L-Glu-4-nitroanilide} (#6# recombinant wild-type, transpeptidation <67>) <67> 1.4 mM L-Glutamic acid gamma-(4-nitroanilide) CHEBI:NONE_148551 glycylglycine CHEBI:17201 2.3.2.2 #6# recombinant wild-type, transpeptidation <67> Y Y ECO:0000006 Pubmed:8827453 BRENDA <67> Ikeda, Y.; Fujii, J.; Taniguchi, N.: Effects of substitutions of the conserved histidine residues in human gamma-glutamyl transpeptidase. J. Biochem. (1996) 119, 1166-1170. {Pubmed:8827453}; PENTACON Notes: Request ChEBI ID: L-Glutamic acid gamma-(4-nitroanilide): CID 57369855 AAP, DGA, ASD 12/7/2011 1111 2200002238 Jenn P08684 1576 CYP3A4 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.00749 {Quinine} (#2# recombinant CYP3A4 <1>) <1> 0.00749 nmol/min/mg quinine CHEBI:15854 Y Y ECO:0000006 Pubmed:8968357 PENTACON Added by PENTACON; PENTACON Notes: recombinant CYP3A4 AAP, DGA, ASD 4/21/2014 3 2200002239 Jenn P33261 1557 CYP2C19 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.000196 {Quinine} (#2# recombinant CYP2C19 <1>) <1> 0.000196 nmol/min/mg quinine CHEBI:15854 Y Y ECO:0000006 Pubmed:8968357 PENTACON Added by PENTACON; PENTACON Notes: recombinant CYP2C19 AAP, DGA, ASD 4/21/2014 3 2200002240 Jenn P33261 1557 CYP2C19 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.046 {Quinine} (#2# recombinant CYP2C19 <1>) <1> 0.046 mM quinine CHEBI:15854 1.14.13.67 #2# recombinant CYP2C19 <1> Y Y ECO:0000006 Pubmed:8968357 BRENDA <1> Zhao, X.J.; Yokoyama, H.; Chiba, K.; Wanwimolruk, S.; Ishizaki, T.: Identification of human cytochrome P450 isoforms involved in the hydroxylation of quinine by human liver microsomes and nine recombinant human cytochromes P450. J. Pharmacol. Exp. Ther. (1996) 279, 1327-1334. {Pubmed:8968357} AAP, DGA, ASD 12/7/2011 1111 2200002241 Jenn P08684 1576 CYP3A4 Homo sapiens 9606 Comment/biophysicochemical properties/KM #2# 0.114 {Quinine} (#2# recombinant CYP3A4 <1>) <1> 0.114 mM quinine CHEBI:15854 1.14.13.67 #2# recombinant CYP3A4 <1> Y Y ECO:0000006 Pubmed:8968357 BRENDA <1> Zhao, X.J.; Yokoyama, H.; Chiba, K.; Wanwimolruk, S.; Ishizaki, T.: Identification of human cytochrome P450 isoforms involved in the hydroxylation of quinine by human liver microsomes and nine recombinant human cytochromes P450. J. Pharmacol. Exp. Ther. (1996) 279, 1327-1334. {Pubmed:8968357} AAP, DGA, ASD 12/7/2011 1111 2200002242 Jenn Q99487 5051 PAFAH2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1700 {1-decanoyl-2-(4-nitrophenylglutaryl) phosphate} <6> 1700.0 nmol/min/mg 1-decanoyl-2-(4-nitrophenylglutaryl) phosphate CHEBI:NONE_148566 Y Y ECO:0000006 Pubmed:9494101 PENTACON Added by PENTACON; PENTACON Notes: Request ChEBI ID: 1-decanoyl-2-(4-nitrophenylglutaryl) phosphate AAP 4/21/2014 3 2200002243 Jenn Q99487 5051 PAFAH2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 35000 {Platelet activating factor} <6> 35000.0 nmol/min/mg 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine CHEBI:44811 Y Y ECO:0000006 Pubmed:9494101 PENTACON Added by PENTACON AAP 4/21/2014 3 2200002244 Jenn Q99487 5051 PAFAH2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #8# 0.01 {1-decanoyl-2-(4-nitrophenylglutaryl) phosphate} <6> 0.01 mM 1-decanoyl-2-(4-nitrophenylglutaryl) phosphate CHEBI:NONE_148566 3.1.1.4 Y Y ECO:0000006 Pubmed:9494101 BRENDA <6> Rice, S.Q.J.; Southan, C.; Boyd, H.F.; Terrett, J.A.; MacPhee, C.H.; Moores, K.; Gloger, I.S.; Tew, D.G.: Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor. Biochem. J. (1998) 330, 1309-1315. {Pubmed:9494101}; PENTACON Notes: Request ChEBI ID: 1-decanoyl-2-(4-nitrophenylglutaryl) phosphate AAP 12/7/2011 1111 2200002245 Jenn Q99487 5051 PAFAH2 Homo sapiens 9606 Comment/biophysicochemical properties/KM #8# 0.042 {Platelet activating factor} <6> 0.042 mM 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine CHEBI:44811 3.1.1.4 Y Y ECO:0000006 Pubmed:9494101 BRENDA <6> Rice, S.Q.J.; Southan, C.; Boyd, H.F.; Terrett, J.A.; MacPhee, C.H.; Moores, K.; Gloger, I.S.; Tew, D.G.: Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor. Biochem. J. (1998) 330, 1309-1315. {Pubmed:9494101} AAP 12/7/2011 1111 2200002246 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.04 {leukotriene A4} (#3# pH 7.4, 25°C <6>) <6> 0.04 mM leukotriene A4 CHEBI:15651 Y Y ECO:0000006 Pubmed:9554994 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 25°C AAP, DGA, ASD 4/21/2014 3 2200002247 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/Vmax #3# 14000 {leukotriene A4} (#3# pH 7.4, 25°C <6>) <6> 14000.0 nmol/min/mg leukotriene A4 CHEBI:15651 Y Y ECO:0000006 Pubmed:9554994 PENTACON Added by PENTACON; PENTACON Notes: pH 7.4, 25°C AAP, DGA, ASD 4/21/2014 3 2200002248 Jenn Q16873 4056 LTC4S Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.0004 {glutathione} (#3# pH 7.4, 25°C <6>) <6> 0.0004 mM glutathione CHEBI:16856 4.4.1.20 #3# pH 7.4, 25°C <6> Y Y ECO:0000006 Pubmed:9554994 BRENDA <6> Gupta, N.; Gresser, M.J.; Ford-Hutchinson, A.W.: Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase. Biochim. Biophys. Acta (1998) 1391, 157-168. {Pubmed:9554994} (c) AAP, DGA, ASD 12/7/2011 1111 2200002249 Jenn P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.00055 {1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine} (#3# phospholipase activity of recombinant enzyme devoid of sialic acid, expressed in baby hamster kidney cells <47>) <47> 0.00055 mM 1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine CHEBI:NONE_148567 2.3.1.43 #3# phospholipase activity of recombinant enzyme devoid of sialic acid, expressed in baby hamster kidney cells <47> Y Y ECO:0000006 Pubmed:9555945 BRENDA <47> Lacko, A.G.; Reason, A.J.; Nuckolls, C.; Kudchodkar, B.J.; Nair, M.P.; Sundarrajan, G.; Pritchard, P.H.; Morris, H.R.; Dell, A.: Characterization of recombinant human plasma lecithin: cholesterol acyltransferase (LCAT): N-linked carbohydrate structures and catalytic properties. J. Lipid Res. (1998) 39, 807-820. {Pubmed:9555945}; PENTACON Notes: Request ChEBI ID: 1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine AAP, DGA 12/7/2011 1111 2200002250 Jenn P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.00014 {1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine} (#3# phospholipase activity <47>) <47> 0.00014 mM 1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine CHEBI:NONE_148567 2.3.1.43 #3# phospholipase activity <47> Y Y ECO:0000006 Pubmed:9555945 BRENDA <47> Lacko, A.G.; Reason, A.J.; Nuckolls, C.; Kudchodkar, B.J.; Nair, M.P.; Sundarrajan, G.; Pritchard, P.H.; Morris, H.R.; Dell, A.: Characterization of recombinant human plasma lecithin: cholesterol acyltransferase (LCAT): N-linked carbohydrate structures and catalytic properties. J. Lipid Res. (1998) 39, 807-820. {Pubmed:9555945}; PENTACON Notes: Request ChEBI ID: 1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine AAP, DGA 12/7/2011 1111 2200002251 Jenn P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.00034 {1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine} (#3# recombinant enzyme devoid of sialic acid, expressed in baby hamster kidney cells <47>) <47> 0.00034 mM 1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine CHEBI:NONE_148567 2.3.1.43 #3# recombinant enzyme devoid of sialic acid, expressed in baby hamster kidney cells <47> Y Y ECO:0000006 Pubmed:9555945 BRENDA <47> Lacko, A.G.; Reason, A.J.; Nuckolls, C.; Kudchodkar, B.J.; Nair, M.P.; Sundarrajan, G.; Pritchard, P.H.; Morris, H.R.; Dell, A.: Characterization of recombinant human plasma lecithin: cholesterol acyltransferase (LCAT): N-linked carbohydrate structures and catalytic properties. J. Lipid Res. (1998) 39, 807-820. {Pubmed:9555945}; PENTACON Notes: Request ChEBI ID: 1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine AAP, DGA 12/7/2011 1111 2200002252 Jenn P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM #3# 0.00019 {1,2-bis-(1-pyrenebutanoyl)-sn-gycero-3-phosphocholine} (#3# phospholipase activity of recombinant enzyme expressed in baby hamster kidney cells <47>) <47> 0.00019 mM 1,2-bis-(1-pyrenebutanoyl)-sn-gycero-3-phosphocholine CHEBI:NONE_148568 2.3.1.43 #3# phospholipase activity of recombinant enzyme expressed in baby hamster kidney cells <47> Y Y ECO:0000006 Pubmed:9555945 BRENDA <47> Lacko, A.G.; Reason, A.J.; Nuckolls, C.; Kudchodkar, B.J.; Nair, M.P.; Sundarrajan, G.; Pritchard, P.H.; Morris, H.R.; Dell, A.: Characterization of recombinant human plasma lecithin: cholesterol acyltransferase (LCAT): N-linked carbohydrate structures and catalytic properties. J. Lipid Res. (1998) 39, 807-820. {Pubmed:9555945}; PENTACON Notes: Request ChEBI ID: 1,2-bis-(1-pyrenebutanoyl)-sn-glycero-3-phosphocholine AAP, DGA 12/7/2011 1111 2200002253 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin; IC50: 750.0 nM; Cyclooxygenase-2; CHEBI:100173 (indomethacin) 750.0 nM indomethacin CHEBI:100173 arachidonate CHEBI:32395 17638 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002254 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 10; IC50: 60.0 nM; Cyclooxygenase-2; CHEBI:258373 60.0 nM Indomethacin derivative, 10 CHEBI:258373 arachidonate CHEBI:32395 22957 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002255 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 11; IC50: 75.0 nM; Cyclooxygenase-2; CHEBI:258629 75.0 nM Indomethacin derivative, 11 CHEBI:258629 arachidonate CHEBI:32395 22958 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002256 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 12; IC50: 50.0 nM; Cyclooxygenase-2; CHEBI:258602 50.0 nM Indomethacin derivative, 12 CHEBI:258602 arachidonate CHEBI:32395 22959 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002257 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 13; IC50: 120.0 nM; Cyclooxygenase-2; CHEBI:258273 120.0 nM Indomethacin derivative, 13 CHEBI:258273 arachidonate CHEBI:32395 22960 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002258 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 14; IC50: 60.0 nM; Cyclooxygenase-2; CHEBI:258615 60.0 nM Indomethacin derivative, 14 CHEBI:258615 arachidonate CHEBI:32395 22961 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002259 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 15; IC50: 50.0 nM; Cyclooxygenase-2; CHEBI:258787 50.0 nM Indomethacin derivative, 15 CHEBI:258787 arachidonate CHEBI:32395 22962 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002260 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 16; IC50: >16500 nM; Cyclooxygenase-2; CHEBI:258316 nM Indomethacin derivative, 16 CHEBI:258316 arachidonate CHEBI:32395 22963 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002261 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 17; IC50: >16500 nM; Cyclooxygenase-2; CHEBI:258289 nM Indomethacin derivative, 17 CHEBI:258289 arachidonate CHEBI:32395 22964 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002262 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 18; IC50: 700.0 nM; Cyclooxygenase-2; CHEBI:258695 700.0 nM Indomethacin derivative, 18 CHEBI:258695 arachidonate CHEBI:32395 22965 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002263 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 19; IC50: 60.0 nM; Cyclooxygenase-2; CHEBI:258321 60.0 nM Indomethacin derivative, 19 CHEBI:258321 arachidonate CHEBI:32395 22966 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002264 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 20; IC50: 50.0 nM; Cyclooxygenase-2; CHEBI:258407 50.0 nM Indomethacin derivative, 20 CHEBI:258407 arachidonate CHEBI:32395 22967 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002265 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 21; IC50: >66000 nM; Cyclooxygenase-2; CHEBI:258849 nM Indomethacin derivative, 21 CHEBI:258849 arachidonate CHEBI:32395 22968 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002266 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 22; IC50: >66000 nM; Cyclooxygenase-2; CHEBI:258881 nM Indomethacin derivative, 22 CHEBI:258881 arachidonate CHEBI:32395 22969 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002267 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 23; IC50: 2500.0 nM; Cyclooxygenase-2; CHEBI:258967 2500.0 nM Indomethacin derivative, 23 CHEBI:258967 arachidonate CHEBI:32395 22970 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002268 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 4; IC50: 700.0 nM; Cyclooxygenase-2; CHEBI:259092 700.0 nM Indomethacin derivative, 4 CHEBI:259092 arachidonate CHEBI:32395 22951 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002269 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 5; IC50: 250.0 nM; Cyclooxygenase-2; CHEBI:216294 250.0 nM Indomethacin derivative, 5 CHEBI:216294 arachidonate CHEBI:32395 22952 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002270 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 6; IC50: 250.0 nM; Cyclooxygenase-2; CHEBI:133478 250.0 nM Indomethacin derivative, 6 CHEBI:133478 arachidonate CHEBI:32395 22953 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002271 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 7; IC50: 120.0 nM; Cyclooxygenase-2; CHEBI:258213 120.0 nM Indomethacin derivative, 7 CHEBI:258213 arachidonate CHEBI:32395 22954 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002272 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 8; IC50: 40.0 nM; Cyclooxygenase-2; CHEBI:258372 40.0 nM Indomethacin derivative, 8 CHEBI:258372 arachidonate CHEBI:32395 22955 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002273 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin derivative, 9; IC50: 300.0 nM; Cyclooxygenase-2; CHEBI:258406 300.0 nM Indomethacin derivative, 9 CHEBI:258406 arachidonate CHEBI:32395 22956 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002274 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Meclofenamic acid; IC50: 50.0 nM; Cyclooxygenase-2; CHEBI:110531 50.0 nM Meclofenamic acid CHEBI:110531 arachidonate CHEBI:32395 22971 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002275 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Meclofenamic acid derivative, 24; IC50: 5500.0 nM; Cyclooxygenase-2; CHEBI:348088 5500.0 nM Meclofenamic acid derivative, 24 CHEBI:348088 arachidonate CHEBI:32395 22972 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002276 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Meclofenamic acid derivative, 25; IC50: 60.0 nM; Cyclooxygenase-2; CHEBI:348823 60.0 nM Meclofenamic acid derivative, 25 CHEBI:348823 arachidonate CHEBI:32395 22973 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002277 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Meclofenamic acid derivative, 26; IC50: 600.0 nM; Cyclooxygenase-2; CHEBI:349120 600.0 nM Meclofenamic acid derivative, 26 CHEBI:349120 arachidonate CHEBI:32395 22974 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002278 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Meclofenamic acid derivative, 27; IC50: 150.0 nM; Cyclooxygenase-2; CHEBI:348276 150.0 nM Meclofenamic acid derivative, 27 CHEBI:348276 arachidonate CHEBI:32395 22975 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002279 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Meclofenamic acid derivative, 28; IC50: 1000.0 nM; Cyclooxygenase-2; CHEBI:348010 1000.0 nM Meclofenamic acid derivative, 28 CHEBI:348010 arachidonate CHEBI:32395 22976 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002280 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Meclofenamic acid derivative, 29; IC50: 200.0 nM; Cyclooxygenase-2; CHEBI:347576 200.0 nM Meclofenamic acid derivative, 29 CHEBI:347576 arachidonate CHEBI:32395 22977 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002281 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Meclofenamic acid derivative, 30; IC50: 4500.0 nM; Cyclooxygenase-2; CHEBI:348179 4500.0 nM Meclofenamic acid derivative, 30 CHEBI:348179 arachidonate CHEBI:32395 22978 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002282 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Meclofenamic acid derivative, 31; IC50: 70.0 nM; Cyclooxygenase-2; CHEBI:348140 70.0 nM Meclofenamic acid derivative, 31 CHEBI:348140 arachidonate CHEBI:32395 22979 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002283 Christie P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Meclofenamic acid derivative, 32; IC50: 400.0 nM; Cyclooxygenase-2; CHEBI:347888 400.0 nM Meclofenamic acid derivative, 32 CHEBI:347888 arachidonate CHEBI:32395 22980 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:10639181 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002284 Chandra P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Km 3alpha-androsteanediol oxidation; Km: 32000.0 nM; 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) 32000.0 nM 5alpha-androstane-3alpha,17beta-diol CHEBI:36713 Y Y ECO:0000006 PubMed:14996743 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200002285 Chandra P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Km Androsterone reduction; Km: 15900.0 nM; 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) 15900.0 nM androsterone CHEBI:16032 Y Y ECO:0000006 PubMed:14996743 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200002286 Chandra P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Km 5a-DHT reduction; Km: 7200.0 nM; 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3) 7200.0 nM 17beta-hydroxy-5alpha-androstan-3-one CHEBI:16330 Y Y ECO:0000006 PubMed:14996743 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200002287 Chandra P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Ki Flufenamic acid; Ki: 140.0 nM; 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3); CHEBI:129860 (flufenamic acid) 140.0 nM flufenamic acid CHEBI:129860 5alpha-androstane-3alpha,17beta-diol CHEBI:36713 17636 pH: 7; temp: 30.00 C Y Y ECO:0000006 PubMed:14996743 BindingDB AAP, ASD 10/25/2013 0 2200002288 Chandra P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Ki Flufenamic acid; Ki: 3100.0 nM; 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3); CHEBI:129860 (flufenamic acid) 3100.0 nM flufenamic acid CHEBI:129860 androsterone CHEBI:16032 17636 pH: 7; temp: 30.00 C Y Y ECO:0000006 PubMed:14996743 BindingDB AAP, ASD 10/25/2013 0 2200002289 Chandra P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Ki Indomethacin; Ki: 270.0 nM; 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3); CHEBI:100173 (indomethacin) 270.0 nM indomethacin CHEBI:100173 5alpha-androstane-3alpha,17beta-diol CHEBI:36713 17638 pH: 7; temp: 30.00 C Y Y ECO:0000006 PubMed:14996743 BindingDB AAP, ASD 10/25/2013 0 2200002290 Chandra P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Ki Indomethacin; Ki: 2100.0 nM; 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3); CHEBI:100173 (indomethacin) 2100.0 nM indomethacin CHEBI:100173 androsterone CHEBI:16032 17638 pH: 7; temp: 30.00 C Y Y ECO:0000006 PubMed:14996743 BindingDB AAP, ASD 10/25/2013 0 2200002291 Chandra P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Km 2.9 micromolar for testosterone 2900.0 nM testosterone CHEBI:17347 Y Y ECO:0000006 PubMed:17166832 PENTACON Added by PENTACON AAP, ASD 4/21/2014 3 2200002292 Chandra P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 EM-1396; IC50: 13.0 nM; 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3); 13.0 nM EM-1396 CHEBI:NONE_148601 testosterone CHEBI:17347 17287 pH: 6; temp: 22.00 C Y Y ECO:0000006 PubMed:17166832 BindingDB PENTACON Notes: Request ChEBI ID: EM-1396 AAP, ASD 10/25/2013 0 2200002293 Chandra P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 EM-1404; IC50: 3.2 nM; 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3); 3.2 nM EM-1404 CHEBI:NONE_148602 testosterone CHEBI:17347 17285 pH: 6; temp: 22.00 C Y Y ECO:0000006 PubMed:17166832 BindingDB PENTACON Notes: Request ChEBI ID: EM-1404 AAP, ASD 10/25/2013 0 2200002294 Chandra P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Ki EM-1404; Ki: 6.9 nM; 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3); 6.9 nM EM-1404 CHEBI:NONE_148602 testosterone CHEBI:17347 17285 pH: 7.5; temp: 37.00 C Y Y ECO:0000006 PubMed:17166832 BindingDB PENTACON Notes: Request ChEBI ID: EM-1404 AAP, ASD 10/25/2013 0 2200002295 Chandra P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 EM-1424; IC50: 9.5 nM; 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3); 9.5 nM EM-1424 CHEBI:NONE_148603 testosterone CHEBI:17347 17286 pH: 6; temp: 22.00 C Y Y ECO:0000006 PubMed:17166832 BindingDB PENTACON Notes: Request ChEBI ID: EM-1424 AAP, ASD 10/25/2013 0 2200002296 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6a; IC50: 77.0 nM; Prostacyclin (IP) Receptor; 77.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6a CHEBI:NONE_148604 23953 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6a; binding activity assay AAP, ASD 10/25/2013 0 2200002297 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6b; EC50: 66.0 nM; Prostacyclin (IP) Receptor; 66.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6b CHEBI:NONE_148605 23955 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6b; functional assay AAP, ASD 10/25/2013 0 2200002298 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6b; IC50: 561.0 nM; Prostacyclin (IP) Receptor; 561.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6b CHEBI:NONE_148605 23955 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6b; binding activity assay AAP, ASD 10/25/2013 0 2200002299 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6c; EC50: 138.0 nM; Prostacyclin (IP) Receptor; 138.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6c CHEBI:NONE_148606 23956 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID:5-(4-phenylbenzyl)oxazole-4-carboxamide, 6c; functional assay AAP, ASD 10/25/2013 0 2200002300 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6c; IC50: 721.0 nM; Prostacyclin (IP) Receptor; 721.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6c CHEBI:NONE_148606 23956 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID:5-(4-phenylbenzyl)oxazole-4-carboxamide, 6c; binding assay AAP, ASD 10/25/2013 0 2200002301 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6d; EC50: 278.0 nM; Prostacyclin (IP) Receptor; 278.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6d CHEBI:NONE_148607 23957 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6d; functional assay AAP, ASD 10/25/2013 0 2200002302 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6d; IC50: 1230.0 nM; Prostacyclin (IP) Receptor; 1230.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6d CHEBI:NONE_148607 23957 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6d; binding assay AAP, ASD 10/25/2013 0 2200002303 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6e; EC50: 2133.0 nM; Prostacyclin (IP) Receptor; 2133.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6e CHEBI:NONE_148608 23958 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6e; functional assay AAP, ASD 10/25/2013 0 2200002304 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6e; IC50: 7160.0 nM; Prostacyclin (IP) Receptor; 7160.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6e CHEBI:NONE_148608 23958 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6e; binding assay AAP, ASD 10/25/2013 0 2200002305 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6f; IC50: 331.0 nM; Prostacyclin (IP) Receptor; 331.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6f CHEBI:NONE_148609 23959 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6f; binding assay AAP, ASD 10/25/2013 0 2200002306 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6f; EC50: 358.0 nM; Prostacyclin (IP) Receptor; 358.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6f CHEBI:NONE_148609 23959 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6f; functional assay AAP, ASD 10/25/2013 0 2200002307 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6g; EC50: 51.0 nM; Prostacyclin (IP) Receptor; 51.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6g CHEBI:NONE_148610 23960 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6g; functional assay AAP, ASD 10/25/2013 0 2200002308 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6g; IC50: 53.0 nM; Prostacyclin (IP) Receptor; 53.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6g CHEBI:NONE_148610 23960 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6g; binding assay AAP, ASD 10/25/2013 0 2200002309 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6h; EC50: 296.0 nM; Prostacyclin (IP) Receptor; 296.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6h CHEBI:NONE_148611 23961 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6h; functional assay AAP, ASD 10/25/2013 0 2200002310 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6h; IC50: 916.0 nM; Prostacyclin (IP) Receptor; 916.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6h CHEBI:NONE_148611 23961 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6h; binding assay AAP, ASD 10/25/2013 0 2200002311 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6i; EC50: 831.0 nM; Prostacyclin (IP) Receptor; 831.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6i CHEBI:NONE_148612 23962 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6i; functional assay AAP, ASD 10/25/2013 0 2200002312 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6i; IC50: 4200.0 nM; Prostacyclin (IP) Receptor; 4200.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6i CHEBI:NONE_148612 23962 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6i; binding assay AAP, ASD 10/25/2013 0 2200002313 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6j; EC50: 16.0 nM; Prostacyclin (IP) Receptor; 16.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6j CHEBI:NONE_148613 23963 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6j; functional assay AAP, ASD 10/25/2013 0 2200002314 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6j; IC50: 476.0 nM; Prostacyclin (IP) Receptor; 476.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6j CHEBI:NONE_148613 23963 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6j; binding assay AAP, ASD 10/25/2013 0 2200002315 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6k; EC50: 1005.0 nM; Prostacyclin (IP) Receptor; 1005.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6k CHEBI:NONE_148614 23964 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6k; functional assay AAP, ASD 10/25/2013 0 2200002316 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6k; IC50: 7600.0 nM; Prostacyclin (IP) Receptor; 7600.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6k CHEBI:NONE_148614 23964 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6k; binding assay AAP, ASD 10/25/2013 0 2200002317 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6l; EC50: 741.0 nM; Prostacyclin (IP) Receptor; 741.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6l CHEBI:NONE_148615 23965 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6l; functional assay AAP, ASD 10/25/2013 0 2200002318 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6l; IC50: 4950.0 nM; Prostacyclin (IP) Receptor; 4950.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6l CHEBI:NONE_148615 23965 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6l; binding assay AAP, ASD 10/25/2013 0 2200002319 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6m; EC50: 476.0 nM; Prostacyclin (IP) Receptor; 476.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6m CHEBI:NONE_148616 23966 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6m; functional assay AAP, ASD 10/25/2013 0 2200002320 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6m; IC50: 4710.0 nM; Prostacyclin (IP) Receptor; 4710.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6m CHEBI:NONE_148616 23966 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6m; binding assay AAP, ASD 10/25/2013 0 2200002321 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6n; EC50: 828.0 nM; Prostacyclin (IP) Receptor; 828.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6n CHEBI:NONE_148617 23967 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6n; functional assay AAP, ASD 10/25/2013 0 2200002322 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6n; IC50: 3480.0 nM; Prostacyclin (IP) Receptor; 3480.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6n CHEBI:NONE_148617 23967 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6n; binding assay AAP, ASD 10/25/2013 0 2200002323 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6o; EC50: 3306.0 nM; Prostacyclin (IP) Receptor; 3306.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6o CHEBI:NONE_148618 23968 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6o; functional assay AAP, ASD 10/25/2013 0 2200002324 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6o; IC50: 12200.0 nM; Prostacyclin (IP) Receptor; 12200.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6o CHEBI:NONE_148618 23968 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6o; binding assay AAP, ASD 10/25/2013 0 2200002325 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6p; EC50: 3584.0 nM; Prostacyclin (IP) Receptor; 3584.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6p CHEBI:NONE_148619 23969 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6p; functional assay AAP, ASD 10/25/2013 0 2200002326 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6p; IC50: 12400.0 nM; Prostacyclin (IP) Receptor; 12400.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6p CHEBI:NONE_148619 23969 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6p; binding assay AAP, ASD 10/25/2013 0 2200002327 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/EC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6q; EC50: 3306.0 nM; Prostacyclin (IP) Receptor; 3306.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6q CHEBI:NONE_148620 23970 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6q; functional assay AAP, ASD 10/25/2013 0 2200002328 Jodi P43119 5739 PTGIR Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6q; IC50: 34100.0 nM; Prostacyclin (IP) Receptor; 34100.0 nM 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6q CHEBI:NONE_148620 23970 pH: 7.4; temp: 22.00 C Y Y ECO:0000006 PubMed:17239589 BindingDB PENTACON Notes: Request ChEBI ID: 5-(4-phenylbenzyl)oxazole-4-carboxamide, 6q; binding assay AAP, ASD 10/25/2013 0 2200002329 Chandra P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 alpha-substituted indomethacin ethanolamide, 14; IC50: 250.0 nM; Cyclooxygenase-2; CHEBI:133883 250.0 nM alpha-substituted indomethacin ethanolamide, 14 CHEBI:133883 22574 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:17656360 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002330 Chandra P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 alpha-substituted indomethacin ethanolamide, 15; IC50: 1000.0 nM; Cyclooxygenase-2; CHEBI:133523 1000.0 nM alpha-substituted indomethacin ethanolamide, 15 CHEBI:133523 22575 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:17656360 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002331 Chandra P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 alpha-substituted indomethacin ethanolamide, 16; IC50: 440.0 nM; Cyclooxygenase-2; CHEBI:133480 440.0 nM alpha-substituted indomethacin ethanolamide, 16 CHEBI:133480 22576 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:17656360 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002332 Chandra P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 alpha-substituted indomethacin ethanolamide, 17; IC50: 85.0 nM; Cyclooxygenase-2; CHEBI:133518 85.0 nM alpha-substituted indomethacin ethanolamide, 17 CHEBI:133518 22577 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:17656360 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002333 Chandra P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 alpha-substituted indomethacin ethanolamide, 6; IC50: 170.0 nM; Cyclooxygenase-2; CHEBI:133605 170.0 nM alpha-substituted indomethacin ethanolamide, 6 CHEBI:133605 22569 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:17656360 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002334 Chandra P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 alpha-substituted indomethacin ethanolamide, 7; IC50: 270.0 nM; Cyclooxygenase-2; CHEBI:133693 270.0 nM alpha-substituted indomethacin ethanolamide, 7 CHEBI:133693 22571 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:17656360 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002335 Chandra P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 alpha-substituted indomethacin ethanolamide, 8; IC50: 100.0 nM; Cyclooxygenase-2; CHEBI:133692 100.0 nM alpha-substituted indomethacin ethanolamide, 8 CHEBI:133692 22572 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:17656360 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002336 Chandra P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 alpha-substituted indomethacin ethanolamide, 9; IC50: 280.0 nM; Cyclooxygenase-2; CHEBI:134429 280.0 nM alpha-substituted indomethacin ethanolamide, 9 CHEBI:134429 22573 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:17656360 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002337 Chandra P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 thiazolidinone derivative, 7; IC50: 262000.0 nM; Cyclooxygenase-2; 262000.0 nM thiazolidinone derivative, 7 CHEBI:NONE_148629 arachidonic acid CHEBI:15843 22342 pH: 8; temp: 37.00 C Y Y ECO:0000006 PubMed:18311898 BindingDB PENTACON Notes: Request ChEBI ID: thiazolidinone derivative, 7 AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002338 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indeno[1,2-c]pyridazin-5-one; IC50: 3800.0 nM; Prostaglandin D Synthase; 3800.0 nM Indeno[1,2-c]pyridazin-5-one CHEBI:NONE_148630 monochlorobimane CHEBI:52158 21629 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request ChEBI ID: Indeno[1,2-c]pyridazin-5-one, CHEMBL125044 AAP, ASD 10/25/2013 0 2200002339 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Methoxynaphthalen-1-yl, 8; IC50: 12400.0 nM; Prostaglandin D Synthase; 12400.0 nM Methoxynaphthalen-1-yl, 8 CHEBI:NONE_148631 monochlorobimane CHEBI:52158 21620 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request ChEBI ID: Methoxynaphthalen-1-yl, 8, Chembl ID: CHEMBL260489 AAP, ASD 10/25/2013 0 2200002340 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Phenol, 11; IC50: 17400.0 nM; Prostaglandin D Synthase; 17400.0 nM Phenol, 11 CHEBI:NONE_148632 monochlorobimane CHEBI:52158 21623 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request ChEBI ID: Phenol, 11 Chembl ID: CHEMBL261678 AAP, ASD 10/25/2013 0 2200002341 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Phenylisothiazole-5-carboxamide, 15; IC50: 75.0 nM; Prostaglandin D Synthase; 75.0 nM Phenylisothiazole-5-carboxamide, 15 CHEBI:NONE_148633 monochlorobimane CHEBI:52158 21627 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request ChEBI ID: Phenylisothiazole-5-carboxamide, 15,Chembl ID: CHEMBL258506 AAP, ASD 10/25/2013 0 2200002342 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Phenylpyridazine-3-carboxylate, 7; IC50: 45000.0 nM; Prostaglandin D Synthase; 45000.0 nM Phenylpyridazine-3-carboxylate, 7 CHEBI:NONE_148634 monochlorobimane CHEBI:52158 21619 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request ChEBI ID: Phenylpyridazine-3-carboxylate, 7, Pubchem ID: CID 24776310 AAP, ASD 10/25/2013 0 2200002343 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyrazol-5-amine, 5; IC50: 33000.0 nM; Prostaglandin D Synthase; 33000.0 nM Pyrazol-5-amine, 5 CHEBI:NONE_148635 monochlorobimane CHEBI:52158 21617 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request ChEBI ID: Pyrazol-5-amine, 5, Chembl ID: CHEMBL405844 AAP, ASD 10/25/2013 0 2200002344 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyrazole, 1; IC50: 890000.0 nM; Prostaglandin D Synthase; 890000.0 nM Pyrazole, 1 CHEBI:NONE_148636 monochlorobimane CHEBI:52158 21615 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request ChEBI ID: Pyrazole, 1, Chembl ID: CHEMBL406105 AAP, ASD 10/25/2013 0 2200002345 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyrazole, 9; IC50: 26400.0 nM; Prostaglandin D Synthase; 26400.0 nM Pyrazole, 9 CHEBI:NONE_148637 monochlorobimane CHEBI:52158 21621 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request ChEBI ID: Pyrazole, 9, Chembl ID: CHEMBL408265 AAP, ASD 10/25/2013 0 2200002346 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyrazolylisoxazole, 14; IC50: 920.0 nM; Prostaglandin D Synthase; 920.0 nM Pyrazolylisoxazole, 14 CHEBI:NONE_148638 monochlorobimane CHEBI:52158 21626 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request ChEBI ID: Pyrazolylisoxazole, 14 Chembl ID: CHEMBL265720 AAP, ASD 10/25/2013 0 2200002347 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyrazolylthiazole, 13; IC50: 21.0 nM; Prostaglandin D Synthase; 21.0 nM Pyrazolylthiazole, 13 CHEBI:NONE_148639 monochlorobimane CHEBI:52158 21625 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request ChEBI ID: Pyrazolylthiazole, 13, Chembl ID: CHEMBL261777 AAP, ASD 10/25/2013 0 2200002348 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyridine-3-carboxylate; IC50: 1500.0 nM; Prostaglandin D Synthase; 1500.0 nM Pyridine-3-carboxylate CHEBI:NONE_148640 monochlorobimane CHEBI:52158 21628 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request ChEBI ID: Pyridine-3-carboxylate AAP, ASD 10/25/2013 0 2200002349 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyridine, 10; IC50: 34700.0 nM; Prostaglandin D Synthase; 34700.0 nM Pyridine, 10 CHEBI:NONE_148641 monochlorobimane CHEBI:52158 21622 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request ChEBI ID: Pyridine, 10, Chembl ID: CHEMBL260289 AAP, ASD 10/25/2013 0 2200002350 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Thiazole, 4; IC50: 994.0 nM; Prostaglandin D Synthase; 994.0 nM Thiazole, 4 CHEBI:NONE_148642 monochlorobimane CHEBI:52158 21616 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request ChEBI ID: Thiazole, 4, Chembl ID: CHEMBL264951 AAP, ASD 10/25/2013 0 2200002351 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Thiazylamino,ol 12; IC50: 138.0 nM; Prostaglandin D Synthase; 138.0 nM Thiazolylamino, 12 CHEBI:NONE_148643 monochlorobimane CHEBI:52158 21624 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request ChEBI ID: Thiazolylamino, 12, Chembl ID: CHEMBL258467 AAP, ASD 10/25/2013 0 2200002352 Jenn O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Tranilast; IC50: 11600.0 nM; Prostaglandin D Synthase; 11600.0 nM Tranilast CHEBI:NONE_148644 monochlorobimane CHEBI:52158 21613 pH: 7.2; temp: 22.00 C Y Y ECO:0000006 PubMed:18341273 BindingDB PENTACON Notes: Request CHebi ID: Tranilast Chembl ID: CHEMBL415324 AAP, ASD 10/25/2013 0 2200002353 Jenn P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Ki 3,5-dichlorosalicylic acid; Ki: 94000.0 nM; 17-beta-Hydroxysteroid Dehydrogenase 5 (17-beta-HSD5, AKR1C3); CHEBI:560901 94000.0 nM 3,5-dichlorosalicylic acid CHEBI:NONE_148645 NADP CHEBI:25523 26269 pH: 7.4; temp: 25.00 C Y Y ECO:0000006 PubMed:18620380 BindingDB PENTACON Notes: Request ChEBI ID: 3,5-dichlorosalicylic acid Chembl ID: CHEMBL449129 AAP, ASD 10/25/2013 0 2200002354 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: <3e+2 nM; Cyclooxygenase-2 (COX-2); nM celecoxib CHEBI:41423 arachidonic acid CHEBI:15843 91683 Y Y ECO:0000006 PubMed:18951238 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002355 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: >1.00e+5 nM; Cyclooxygenase-1 (COX-1); nM celecoxib CHEBI:41423 arachidonic acid CHEBI:15843 91683 Y Y ECO:0000006 PubMed:18951238 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002356 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin; IC50: 260.0 nM; Cyclooxygenase-1 (COX-1); CHEBI:100173 (indomethacin) 260.0 nM indomethacin CHEBI:100173 arachidonic acid CHEBI:15843 17638 Y Y ECO:0000006 PubMed:18951238 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002357 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Indomethacin; IC50: 2630.0 nM; Cyclooxygenase-2 (COX-2); CHEBI:100173 (indomethacin) 2630.0 nM indomethacin CHEBI:100173 arachidonic acid CHEBI:15843 17638 Y Y ECO:0000006 PubMed:18951238 BindingDB AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002358 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyrazolyl benzenesulfonamide derivative, 7a; IC50: 1350.0 nM; Cyclooxygenase-2 (COX-2); 1350.0 nM Pyrazolyl benzenesulfonamide derivative, 7a CHEBI:NONE_148646 arachidonic acid CHEBI:15843 91678 Y Y ECO:0000006 PubMed:18951238 BindingDB PENTACON Notes: Request ChEBI ID: Pyrazolyl benzenesulfonamide derivative, 7a Pubchem ID: CID 57411990 AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002359 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyrazolyl benzenesulfonamide derivative, 7a; IC50: 83620.0 nM; Cyclooxygenase-1 (COX-1); 83620.0 nM Pyrazolyl benzenesulfonamide derivative, 7a CHEBI:NONE_148646 arachidonic acid CHEBI:15843 91678 Y Y ECO:0000006 PubMed:18951238 BindingDB PENTACON Notes: Request ChEBI ID: Pyrazolyl benzenesulfonamide derivative, 7a Pubchem ID: CID 57411990 AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002360 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyrazolyl benzenesulfonamide derivative, 7b; IC50: 1260.0 nM; Cyclooxygenase-2 (COX-2); 1260.0 nM Pyrazolyl benzenesulfonamide derivative, 7b CHEBI:NONE_148647 arachidonic acid CHEBI:15843 91679 Y Y ECO:0000006 PubMed:18951238 BindingDB PENTACON Notes: Request ChEBI ID: Pyrazolyl benzenesulfonamide derivative, 7b, Pubchem ID: CID 57411991 AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002361 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyrazolyl benzenesulfonamide derivative, 7b; IC50: 76410.0 nM; Cyclooxygenase-1 (COX-1); 76410.0 nM Pyrazolyl benzenesulfonamide derivative, 7b CHEBI:NONE_148647 arachidonic acid CHEBI:15843 91679 Y Y ECO:0000006 PubMed:18951238 BindingDB PENTACON Notes: Request ChEBI ID: Pyrazolyl benzenesulfonamide derivative, 7b, Pubchem ID: CID 57411991 AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002362 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyrazolyl benzenesulfonamide derivative, 9a; IC50: 780.0 nM; Cyclooxygenase-2 (COX-2); 780.0 nM Pyrazolyl benzenesulfonamide derivative, 9a CHEBI:NONE_148648 arachidonic acid CHEBI:15843 91684 Y Y ECO:0000006 PubMed:18951238 BindingDB PENTACON Notes: Request ChEBI ID: Pyrazolyl benzenesulfonamide derivative, 9a, Pubchem ID: CID 25227547 AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002363 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyrazolyl benzenesulfonamide derivative, 9a; IC50: >1.00e+5 nM; Cyclooxygenase-1 (COX-1); nM Pyrazolyl benzenesulfonamide derivative, 9a CHEBI:NONE_148648 arachidonic acid CHEBI:15843 91684 Y Y ECO:0000006 PubMed:18951238 BindingDB PENTACON Notes: Request ChEBI ID: Pyrazolyl benzenesulfonamide derivative, 9a, Pubchem ID: CID 25227547 AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002364 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyrazolyl benzenesulfonamide derivative, 9b; IC50: 920.0 nM; Cyclooxygenase-2 (COX-2); 920.0 nM Pyrazolyl benzenesulfonamide derivative, 9b CHEBI:NONE_148649 arachidonic acid CHEBI:15843 91685 Y Y ECO:0000006 PubMed:18951238 BindingDB PENTACON Notes: Request ChEBI ID: Pyrazolyl benzenesulfonamide derivative, 9b, Pubchem ID: CID 25227548 AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002365 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Pyrazolyl benzenesulfonamide derivative, 9b; IC50: 94220.0 nM; Cyclooxygenase-1 (COX-1); 94220.0 nM Pyrazolyl benzenesulfonamide derivative, 9b CHEBI:NONE_148649 arachidonic acid CHEBI:15843 91685 Y Y ECO:0000006 PubMed:18951238 BindingDB PENTACON Notes: Request ChEBI ID: Pyrazolyl benzenesulfonamide derivative, 9b, Pubchem ID: CID 25227548 AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002366 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 5a; IC50: 210.0 nM; Cyclooxygenase-2 (COX-2); 210.0 nM 3-benzyl-2-(4-methylsulfonylphenyl)-1,3- oxazolidine-4(5H)-one, COX inhibitor, 5a CHEBI:NONE_148650 arachidonic acid CHEBI:15843 93103 Y Y ECO:0000006 Zarghi, A.; Arefi, H.; Dadrass, O.G.; Torabi S.: Design and synthesis of new 2-aryl, 3-benzyl-(1,3-oxazolidine or 1,3-thiazolidine)-4-ones as selective cyclooxygenase (COX-2) inhibitors. Medicinal Chemistry Research (2012); 19(8):782-793. BindingDB PENTACON Notes: Request ChEBI ID: 3-benzyl-2-(4-methylsulfonylphenyl)-1,3- oxazolidine-4(5H)-one AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002367 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 5a; IC50: >1.00e+5 nM; Cyclooxygenase-1 (COX-1); nM 3-benzyl-2-(4-methylsulfonylphenyl)-1,3- oxazolidine-4(5H)-one, COX inhibitor, 5a CHEBI:NONE_148650 arachidonic acid CHEBI:15843 93103 Y Y ECO:0000006 Zarghi, A.; Arefi, H.; Dadrass, O.G.; Torabi S.: Design and synthesis of new 2-aryl, 3-benzyl-(1,3-oxazolidine or 1,3-thiazolidine)-4-ones as selective cyclooxygenase (COX-2) inhibitors. Medicinal Chemistry Research (2012); 19(8):782-793. BindingDB PENTACON Notes: Request ChEBI ID: 3-benzyl-2-(4-methylsulfonylphenyl)-1,3- oxazolidine-4(5H)-one AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002368 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 5b; IC50: 320.0 nM; Cyclooxygenase-2 (COX-2); 320.0 nM 3-Benzyl-2-(4-methylsulfonylphenyl)-1,3-thiazolidine 4(5H)-one, COX inhibitor, 5b CHEBI:NONE_148651 arachidonic acid CHEBI:15843 93104 Y Y ECO:0000006 Zarghi, A.; Arefi, H.; Dadrass, O.G.; Torabi S.: Design and synthesis of new 2-aryl, 3-benzyl-(1,3-oxazolidine or 1,3-thiazolidine)-4-ones as selective cyclooxygenase (COX-2) inhibitors. Medicinal Chemistry Research (2012); 19(8):782-793. BindingDB PENTACON Notes: Request ChEBI ID: 3-Benzyl-2-(4-methylsulfonylphenyl)-1,3-thiazolidine 4(5H)-one AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002369 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 5b; IC50: >1.00e+5 nM; Cyclooxygenase-1 (COX-1); nM 3-Benzyl-2-(4-methylsulfonylphenyl)-1,3-thiazolidine 4(5H)-one, COX inhibitor, 5b CHEBI:NONE_148651 arachidonic acid CHEBI:15843 93104 Y Y ECO:0000006 Zarghi, A.; Arefi, H.; Dadrass, O.G.; Torabi S.: Design and synthesis of new 2-aryl, 3-benzyl-(1,3-oxazolidine or 1,3-thiazolidine)-4-ones as selective cyclooxygenase (COX-2) inhibitors. Medicinal Chemistry Research (2012); 19(8):782-793. BindingDB PENTACON Notes: Request ChEBI ID: 3-Benzyl-2-(4-methylsulfonylphenyl)-1,3-thiazolidine 4(5H)-one AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002370 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 8; IC50: 270.0 nM; Cyclooxygenase-2 (COX-2); 270.0 nM 3-Benzyl-5-methyl-2-(4-methylsufonylphenyl)-1,3-oxazolidine 4(5H)-one, COX inhibitor, 8 CHEBI:NONE_148652 arachidonic acid CHEBI:15843 93105 Y Y ECO:0000006 Zarghi, A.; Arefi, H.; Dadrass, O.G.; Torabi S.: Design and synthesis of new 2-aryl, 3-benzyl-(1,3-oxazolidine or 1,3-thiazolidine)-4-ones as selective cyclooxygenase (COX-2) inhibitors. Medicinal Chemistry Research (2012); 19(8):782-793. BindingDB PENTACON Notes: Request ChEBI ID: 3-Benzyl-5-methyl-2-(4-methylsufonylphenyl)-1,3-oxazolidine 4(5H)-one AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002371 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 8; IC50: 85900.0 nM; Cyclooxygenase-1 (COX-1); 85900.0 nM 3-Benzyl-5-methyl-2-(4-methylsufonylphenyl)-1,3-oxazolidine 4(5H)-one, COX inhibitor, 8 CHEBI:NONE_148652 arachidonic acid CHEBI:15843 93105 Y Y ECO:0000006 Zarghi, A.; Arefi, H.; Dadrass, O.G.; Torabi S.: Design and synthesis of new 2-aryl, 3-benzyl-(1,3-oxazolidine or 1,3-thiazolidine)-4-ones as selective cyclooxygenase (COX-2) inhibitors. Medicinal Chemistry Research (2012); 19(8):782-793. BindingDB PENTACON Notes: Request ChEBI ID: 3-Benzyl-5-methyl-2-(4-methylsufonylphenyl)-1,3-oxazolidine 4(5H)-one AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002372 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 9; IC50: 340.0 nM; Cyclooxygenase-2 (COX-2); 340.0 nM 3-Benzyl-5-methyl-2-(4-methylsufonylphenyl)-1,3-thiazolidine 4(5H)-one, COX inhibitor, 9 CHEBI:NONE_148653 arachidonic acid CHEBI:15843 93106 Y Y ECO:0000006 Zarghi, A.; Arefi, H.; Dadrass, O.G.; Torabi S.: Design and synthesis of new 2-aryl, 3-benzyl-(1,3-oxazolidine or 1,3-thiazolidine)-4-ones as selective cyclooxygenase (COX-2) inhibitors. Medicinal Chemistry Research (2012); 19(8):782-793. BindingDB PENTACON Notes: Request ChEBI ID: 3-Benzyl-5-methyl-2-(4-methylsufonylphenyl)-1,3-thiazolidine 4(5H)-one AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002373 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 9; IC50: 75600.0 nM; Cyclooxygenase-1 (COX-1); 75600.0 nM 3-Benzyl-5-methyl-2-(4-methylsufonylphenyl)-1,3-thiazolidine 4(5H)-one, COX inhibitor, 9 CHEBI:NONE_148653 arachidonic acid CHEBI:15843 93106 Y Y ECO:0000006 Zarghi, A.; Arefi, H.; Dadrass, O.G.; Torabi S.: Design and synthesis of new 2-aryl, 3-benzyl-(1,3-oxazolidine or 1,3-thiazolidine)-4-ones as selective cyclooxygenase (COX-2) inhibitors. Medicinal Chemistry Research (2012); 19(8):782-793. BindingDB PENTACON Notes: Request ChEBI ID: 3-Benzyl-5-methyl-2-(4-methylsufonylphenyl)-1,3-thiazolidine 4(5H)-one AAP, DGA, AAP-M, ASD 10/25/2013 0 2200002374 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 2a; IC50: 350 nM; Cyclooxygenase-2 (COX-2); 350.0 nM 2-(4-Methylsulfonylphenyl)-3-phenyl-1,3-benzdiazinan-4-one, COX inhibitor, 2a CHEBI:NONE_148654 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-Methylsulfonylphenyl)-3-phenyl-1,3-benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002375 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 2a; IC50: 99800 nM; Cyclooxygenase-1 (COX-1); 99800.0 nM 2-(4-Methylsulfonylphenyl)-3-phenyl-1,3-benzdiazinan-4-one, COX inhibitor, 2a CHEBI:NONE_148654 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-Methylsulfonylphenyl)-3-phenyl-1,3-benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002376 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 2b; IC50: 70 nM; Cyclooxygenase-2 (COX-2); 70.0 nM 3-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one, COX inhibitor, 2b CHEBI:NONE_148655 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002377 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 2b; IC50: 40100 nM; Cyclooxygenase-1 (COX-1); 40100.0 nM 3-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one, COX inhibitor, 2b CHEBI:NONE_148655 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002378 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 2c; IC50: 170 nM; Cyclooxygenase-2 (COX-2); 170.0 nM 3-(4-Chlorophenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one, COX inhibitor, 2c CHEBI:NONE_148656 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Chlorophenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002379 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 2c; IC50: 17700 nM; Cyclooxygenase-1 (COX-1); 17700.0 nM 3-(4-Chlorophenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one, COX inhibitor, 2c CHEBI:NONE_148656 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Chlorophenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002380 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 2d; IC50: 100 nM; Cyclooxygenase-2 (COX-2); 100.0 nM 3-(4-Methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one, COX inhibitor, 2d CHEBI:NONE_148657 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002381 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 2d; IC50: 37200 nM; Cyclooxygenase-1 (COX-1); 37200.0 nM 3-(4-Methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one, COX inhibitor, 2d CHEBI:NONE_148657 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002382 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 2e; IC50: 70 nM; Cyclooxygenase-2 (COX-2); 70.0 nM 3-(4-Methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one, COX inhibitor, 2e CHEBI:NONE_148658 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002383 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 2e; IC50: 33400 nM; Cyclooxygenase-1 (COX-1); 33400.0 nM 3-(4-Methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one, COX inhibitor, 2e CHEBI:NONE_148658 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002384 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 4a; IC50: 120 nM; Cyclooxygenase-2 (COX-2); 120.0 nM 3-(4-Methylsulfonylphenyl)-2-phenyl-1,3-benzdiazinan-4- one, COX inhibitor, 4a CHEBI:NONE_148659 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Methylsulfonylphenyl)-2-phenyl-1,3-benzdiazinan-4- one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002385 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 4a; IC50: 24100 nM; Cyclooxygenase-1 (COX-1); 24100.0 nM 3-(4-Methylsulfonylphenyl)-2-phenyl-1,3-benzdiazinan-4- one, COX inhibitor, 4a CHEBI:NONE_148659 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Methylsulfonylphenyl)-2-phenyl-1,3-benzdiazinan-4- one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002386 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 4b; IC50: 90 nM; Cyclooxygenase-2 (COX-2); 90.0 nM 2-(4-Fluorophenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one, COX inhibitor, 4b CHEBI:NONE_148660 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-Fluorophenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002387 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 4b; IC50: 31800 nM; Cyclooxygenase-1 (COX-1); 31800.0 nM 2-(4-Fluorophenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one, COX inhibitor, 4b CHEBI:NONE_148660 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-Fluorophenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002388 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 4c; IC50: 220 nM; Cyclooxygenase-2 (COX-2); 220.0 nM 2-(4-Chlorophenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one, COX inhibitor, 4c CHEBI:NONE_148661 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-Chlorophenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002389 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 4c; IC50: 20900 nM; Cyclooxygenase-1 (COX-1); 20900.0 nM 2-(4-Chlorophenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one, COX inhibitor, 4c CHEBI:NONE_148661 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-Chlorophenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002390 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 4d; IC50: 110 nM; Cyclooxygenase-2 (COX-2); 110.0 nM 2-(4-Methylphenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one, COX inhibitor, 4d CHEBI:NONE_148662 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-Methylphenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002391 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 4d; IC50: 24100 nM; Cyclooxygenase-1 (COX-1); 24100.0 nM 2-(4-Methylphenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one, COX inhibitor, 4d CHEBI:NONE_148662 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-Methylphenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002392 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 4e; IC50: 110 nM; Cyclooxygenase-2 (COX-2); 110.0 nM 2-(4-Methoxyphenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one, COX inhibitor, 4e CHEBI:NONE_148663 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-Methoxyphenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002393 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 COX inhibitor, 4e; IC50: 29700 nM; Cyclooxygenase-1 (COX-1); 29700.0 nM 2-(4-Methoxyphenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one, COX inhibitor, 4e CHEBI:NONE_148663 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-Methoxyphenyl)-3-(4-methylsulfonylphenyl)-1,3- benzdiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002394 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 60.0 nM; Cyclooxygenase-2 (COX-2); CHEBI:118694 (celecoxib) 60.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002395 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 24300.0 nM; Cyclooxygenase-1 (COX-1); CHEBI:118694 (celecoxib) 24300.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:22076641 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002396 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 60.0 nM; Cyclooxygenase-2 (COX-2); CHEBI:118694 (celecoxib) 60.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:21886896 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002397 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 24300.0 nM; Cyclooxygenase-1 (COX-1); CHEBI:118694 (celecoxib) 24300.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:21886896 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002398 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-[4-(Methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (5-[4-(Methylsulfonyl)phenyl]-5-phenylhydantoin, Cox Inhibitor, 4; IC50: 77 nM; Cyclooxygenase-2 (COX-2); 77.0 nM 5-[4-(Methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (5-[4-(Methylsulfonyl)phenyl]-5-phenylhydantoin CHEBI:NONE_148665 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:21886896 PENTACON PENTACON Notes: Request ChEBI ID: 5-[4-(Methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (5-[4-(Methylsulfonyl)phenyl]-5-phenylhydantoin' AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002399 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-[4-(Methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (5-[4-(Methylsulfonyl)phenyl]-5-phenylhydantoin, Cox Inhibitor 4; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM 5-[4-(Methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (5-[4-(Methylsulfonyl)phenyl]-5-phenylhydantoin CHEBI:NONE_148665 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:21886896 PENTACON PENTACON Notes: Request ChEBI ID: 5-[4-(Methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (5-[4-(Methylsulfonyl)phenyl]-5-phenylhydantoin' AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002400 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-Methyl-5-[4-(methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (N-3-Methyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin, Cox Inhibitor, 5; IC50: 81 nM; Cyclooxygenase-2 (COX-2); 81.0 nM 5-[4-(Methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (5-[4-(Methylsulfonyl)phenyl]-5-phenylhydantoin CHEBI:NONE_148665 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:21886896 PENTACON PENTACON Notes: Request ChEBI ID: 5-[4-(Methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (5-[4-(Methylsulfonyl)phenyl]-5-phenylhydantoin' AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002401 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-Methyl-5-[4-(methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (N-3-Methyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin, Cox Inhibitor 5; IC50: 22690 nM; Cyclooxygenase-1 (COX-1); 22690.0 nM 3-Methyl-5-[4-(methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (N-3-Methyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin CHEBI:NONE_148666 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:21886896 PENTACON PENTACON Notes: Request ChEBI ID: 3-Methyl-5-[4-(methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (N-3-Methyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002402 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-Ethyl-5-[4-(methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (N-3-Ethyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin, Cox Inhibitor, 6; IC50: 98 nM; Cyclooxygenase-2 (COX-2); 98.0 nM 3-Ethyl-5-[4-(methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (N-3-Ethyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin CHEBI:NONE_148667 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:21886896 PENTACON PENTACON Notes: Request ChEBI ID:3-Ethyl-5-[4-(methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (N-3-Ethyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002403 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-Ethyl-5-[4-(methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (N-3-Ethyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin, Cox Inhibitor 6; IC50: 20210 nM; Cyclooxygenase-1 (COX-1); 20210.0 nM 3-Ethyl-5-[4-(methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (N-3-Ethyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin CHEBI:NONE_148667 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:21886896 PENTACON PENTACON Notes: Request ChEBI ID: 3-Ethyl-5-[4-(methylsulfonyl)phenyl]-5-phenylimidazolidine-2,4-dione (N-3-Ethyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002404 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-[4-(Methylsulfonyl)phenyl]-5-phenyl-3-propylimidazolidine-2,4-dione (5-(4-(Methylsulfonyl)phenyl)-5-phenyl-N-3-propyl-hydantoin, Cox Inhibitor, 7; IC50: 171 nM; Cyclooxygenase-2 (COX-2); 171.0 nM 5-[4-(Methylsulfonyl)phenyl]-5-phenyl-3-propylimidazolidine-2,4-dione (5-(4-(Methylsulfonyl)phenyl)-5-phenyl-N-3-propyl-hydantoin CHEBI:NONE_148668 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:21886896 PENTACON PENTACON Notes: Request ChEBI ID: 5-[4-(Methylsulfonyl)phenyl]-5-phenyl-3-propylimidazolidine-2,4-dione (5-(4-(Methylsulfonyl)phenyl)-5-phenyl-N-3-propyl-hydantoin AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002405 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-[4-(Methylsulfonyl)phenyl]-5-phenyl-3-propylimidazolidine-2,4-dione (5-(4-(Methylsulfonyl)phenyl)-5-phenyl-N-3-propyl-hydantoin, Cox Inhibitor 7; IC50: 12010 nM; Cyclooxygenase-1 (COX-1); 12010.0 nM 5-[4-(Methylsulfonyl)phenyl]-5-phenyl-3-propylimidazolidine-2,4-dione (5-(4-(Methylsulfonyl)phenyl)-5-phenyl-N-3-propyl-hydantoin CHEBI:NONE_148668 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:21886896 PENTACON PENTACON Notes: Request ChEBI ID: 5-[4-(Methylsulfonyl)phenyl]-5-phenyl-3-propylimidazolidine-2,4-dione (5-(4-(Methylsulfonyl)phenyl)-5-phenyl-N-3-propyl-hydantoin AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002406 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-[4-(Methylsulfonyl)phenyl]-5-phenyl-3-(prop-2-en-1-yl)imidazolidine-2,4-dione (N-3-Allyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin, Cox Inhibitor, 8; IC50: 99 nM; Cyclooxygenase-2 (COX-2); 99.0 nM 5-[4-(Methylsulfonyl)phenyl]-5-phenyl-3-(prop-2-en-1-yl)imidazolidine-2,4-dione (N-3-Allyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin CHEBI:NONE_148669 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:21886896 PENTACON PENTACON Notes: Request ChEBI ID: 5-[4-(Methylsulfonyl)phenyl]-5-phenyl-3-(prop-2-en-1-yl)imidazolidine-2,4-dione (N-3-Allyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002407 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 5-[4-(Methylsulfonyl)phenyl]-5-phenyl-3-(prop-2-en-1-yl)imidazolidine-2,4-dione (N-3-Allyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin, Cox Inhibitor 8; IC50:14960 nM; Cyclooxygenase-1 (COX-1); 14960.0 nM 5-[4-(Methylsulfonyl)phenyl]-5-phenyl-3-(prop-2-en-1-yl)imidazolidine-2,4-dione (N-3-Allyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin CHEBI:NONE_148669 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:21886896 PENTACON PENTACON Notes: Request ChEBI ID: 5-[4-(Methylsulfonyl)phenyl]-5-phenyl-3-(prop-2-en-1-yl)imidazolidine-2,4-dione (N-3-Allyl-5-(4-(methylsulfonyl)phenyl)-5-phenylhydantoin AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002408 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 60.0 nM; Cyclooxygenase-2 (COX-2); CHEBI:118694 (celecoxib) 60.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002409 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 24300.0 nM; Cyclooxygenase-1 (COX-1); CHEBI:118694 (celecoxib) 24300.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002410 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(Acetamido)phenyl)-8-benzoyl-quinoline-4-carboxylic acid, Cox Inhibitor 5a; IC50: 80 nM; Cyclooxygenase-2 (COX-2); 80.0 nM 2-(4-(Acetamido)phenyl)-8-benzoyl-quinoline-4-carboxylic acid CHEBI:NONE_148670 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(Acetamido)phenyl)-8-benzoyl-quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002411 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(Acetamido)phenyl)-8-benzoyl-quinoline-4-carboxylic acid, Cox Inhibitor 5a; IC50: 9200 nM; Cyclooxygenase-1 (COX-1); 9200.0 nM 2-(4-(Acetamido)phenyl)-8-benzoyl-quinoline-4-carboxylic acid CHEBI:NONE_148670 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(Acetamido)phenyl)-8-benzoyl-quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002412 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(Acetamido)phenyl)-6-benzoyl-quioline-4-carboxylic acid, Cox Inhibitor 5b; IC50: 85 nM; Cyclooxygenase-2 (COX-2); 85.0 nM 2-(4-(Acetamido)phenyl)-6-benzoyl-quinoline-4-carboxylic acid CHEBI:NONE_148671 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(Acetamido)phenyl)-6-benzoyl-quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002413 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(Acetamido)phenyl)-6-benzoyl-quinoline-4-carboxylic acid, Cox Inhibitor 5b; IC50: 21800 nM; Cyclooxygenase-1 (COX-1); 21800.0 nM 2-(4-(Acetamido)phenyl)-6-benzoyl-quinoline-4-carboxylic acid CHEBI:NONE_148671 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(Acetamido)phenyl)-6-benzoyl-quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002414 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 8-Benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid, Cox Inhibitor 6a; IC50: 69 nM; Cyclooxygenase-2 (COX-2); 69.0 nM 8-Benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid CHEBI:NONE_148672 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON PENTACON Notes: Request ChEBI ID: 8-Benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002415 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 8-Benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid, Cox Inhibitor 6a; IC50: 15900 nM; Cyclooxygenase-1 (COX-1); 15900.0 nM 8-Benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid CHEBI:NONE_148672 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON PENTACON Notes: Request ChEBI ID: 8-Benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002416 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 6-Benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid, Cox Inhibitor 6b; IC50: 77 nM; Cyclooxygenase-2 (COX-2); 77.0 nM 6-Benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid CHEBI:NONE_148673 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON PENTACON Notes: Request ChEBI ID: 6-Benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002417 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 6-Benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid, Cox Inhibitor 6b; IC50: 24400 nM; Cyclooxygenase-1 (COX-1); 24400.0 nM 6-Benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid CHEBI:NONE_148673 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON PENTACON Notes: Request ChEBI ID: 6-Benzoyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002418 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(Azido)phenyl)-8-benzoyl-quinoline-4-carboxylic acid, Cox Inhibitor 8a; IC50: 57 nM; Cyclooxygenase-2 (COX-2); 57.0 nM 2-(4-(Azido)phenyl)-8-benzoyl-quinoline-4-carboxylic acid CHEBI:NONE_148674 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(Azido)phenyl)-8-benzoyl-quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002419 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(Azido)phenyl)-8-benzoyl-quinoline-4-carboxylic acid, Cox Inhibitor 8a; IC50: 65550 nM; Cyclooxygenase-1 (COX-1); 65550.0 nM 2-(4-(Azido)phenyl)-8-benzoyl-quinoline-4-carboxylic acid CHEBI:NONE_148674 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(Azido)phenyl)-8-benzoyl-quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002420 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(Azido)phenyl)-6-benzoyl-quinoline-4-carboxylic acid, Cox Inhibitor 8b; IC50: 77 nM; Cyclooxygenase-2 (COX-2); 77.0 nM 2-(4-(Azido)phenyl)-6-benzoyl-quinoline-4-carboxylic acid CHEBI:NONE_148675 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(Azido)phenyl)-6-benzoyl-quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002421 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(Azido)phenyl)-6-benzoyl-quinoline-4-carboxylic acid, Cox Inhibitor 8b; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM 2-(4-(Azido)phenyl)-6-benzoyl-quinoline-4-carboxylic acid CHEBI:NONE_148675 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(Azido)phenyl)-6-benzoyl-quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002422 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-carboxyl quinoline, Cox Inhibitor A; IC50: 91 nM; Cyclooxygenase-2 (COX-2); 91.0 nM 4-carboxyl quinoline CHEBI:NONE_148676 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON PENTACON Notes: Request ChEBI ID: 4-carboxyl quinoline AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002423 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-carboxyl quinoline, Cox Inhibitor A; IC50: 13400 nM; Cyclooxygenase-1 (COX-1); 13400.0 nM 4-carboxyl quinoline CHEBI:NONE_148676 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20650641 PENTACON PENTACON Notes: Request ChEBI ID: 4-carboxyl quinoline AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002424 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 60.0 nM; Cyclooxygenase-2 (COX-2); CHEBI:118694 (celecoxib) 60.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20061161 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002425 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 24300.0 nM; Cyclooxygenase-1 (COX-1); CHEBI:118694 (celecoxib) 24300.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20061161 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002426 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline, Cox Inhibitor 4; IC50: 110 nM; Cyclooxygenase-2 (COX-2); 110.0 nM 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline CHEBI:NONE_148677 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20061161 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002427 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline, Cox Inhibitor 4; IC50: 33500 nM; Cyclooxygenase-1 (COX-1); 33500.0 nM 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline CHEBI:NONE_148677 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20061161 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002428 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-methyl-2-(4-methylsulfonyl)phenyl)-3-phenylquinoline, Cox Inhibitor 5; IC50: 110 nM; Cyclooxygenase-2 (COX-2); 110.0 nM 4-methyl-2-(4-methylsulfonyl)phenyl)-3-phenylquinoline CHEBI:NONE_148678 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20061161 PENTACON PENTACON Notes: Request ChEBI ID: 4-methyl-2-(4-methylsulfonyl)phenyl)-3-phenylquinoline AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002429 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-methyl-2-(4-methylsulfonyl)phenyl)-3-phenylquinoline, Cox Inhibitor 5; IC50: 13300 nM; Cyclooxygenase-1 (COX-1); 13300.0 nM 4-methyl-2-(4-methylsulfonyl)phenyl)-3-phenylquinoline CHEBI:NONE_148678 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20061161 PENTACON PENTACON Notes: Request ChEBI ID:4-methyl-2-(4-methylsulfonyl)phenyl)-3-phenylquinoline AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002430 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3,4-diphenyl-2-(4-methylsulfonyl)phenyl)-quinoline, Cox Inhibitor 6; IC50: 130 nM; Cyclooxygenase-2 (COX-2); 130.0 nM 3,4-diphenyl-2-(4-methylsulfonyl)phenyl)-quinoline CHEBI:NONE_148679 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20061161 PENTACON PENTACON Notes: Request ChEBI ID: 3,4-diphenyl-2-(4-methylsulfonyl)phenyl)-quinoline AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002431 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3,4-diphenyl-2-(4-methylsulfonyl)phenyl)-quinoline, Cox Inhibitor 6; IC50: 10200 nM; Cyclooxygenase-1 (COX-1); 10200.0 nM 3,4-diphenyl-2-(4-methylsulfonyl)phenyl)-quinoline CHEBI:NONE_148679 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20061161 PENTACON PENTACON Notes: Request ChEBI ID:3,4-diphenyl-2-(4-methylsulfonyl)phenyl)-quinoline AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002432 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-amino-2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline, Cox Inhibitor 7; IC50: 80 nM; Cyclooxygenase-2 (COX-2); 80.0 nM 4-amino-2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline CHEBI:NONE_148680 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20061161 PENTACON PENTACON Notes: Request ChEBI ID: 4-amino-2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002433 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-amino-2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline, Cox Inhibitor 7; IC50: 14400 nM; Cyclooxygenase-1 (COX-1); 14400.0 nM 4-amino-2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline CHEBI:NONE_148680 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20061161 PENTACON PENTACON Notes: Request ChEBI ID: 4-amino-2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002434 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline-4-carboxylic acid, Cox Inhibitor 8; IC50: 70 nM; Cyclooxygenase-2 (COX-2); 70.0 nM 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline-4-carboxylic acid CHEBI:NONE_148681 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20061161 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002435 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline-4-carboxylic acid, Cox Inhibitor 8; IC50: 48100 nM; Cyclooxygenase-1 (COX-1); 48100.0 nM 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline-4-carboxylic acid CHEBI:NONE_148681 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20061161 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(methylsulfonyl)phenyl)-3-phenylquinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002436 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 60.0 nM; Cyclooxygenase-2 (COX-2); CHEBI:118694 (celecoxib) 60.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19596198 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002437 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 24300.0 nM; Cyclooxygenase-1 (COX-1); CHEBI:118694 (celecoxib) 24300.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19596198 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002438 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-Methylsulfonylphenyl)-3-phenyl-1,3-benzthiazinan-4-one, Cox Inhibitor 7a; IC50: 120 nM; Cyclooxygenase-2 (COX-2); 120.0 nM 2-(4-Methylsulfonylphenyl)-3-phenyl-1,3-benzthiazinan-4-one CHEBI:NONE_148682 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19596198 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-Methylsulfonylphenyl)-3-phenyl-1,3-benzthiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002439 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-Methylsulfonylphenyl)-3-phenyl-1,3-benzthiazinan-4-one, Cox Inhibitor 7a; IC50: 16500 nM; Cyclooxygenase-1 (COX-1); 16500.0 nM 2-(4-Methylsulfonylphenyl)-3-phenyl-1,3-benzthiazinan-4-one CHEBI:NONE_148682 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19596198 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-Methylsulfonylphenyl)-3-phenyl-1,3-benzthiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002440 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one, Cox Inhibitor 7b; IC50: 50 nM; Cyclooxygenase-2 (COX-2); 50.0 nM 3-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one CHEBI:NONE_148683 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19596198 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002441 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one, Cox Inhibitor 7b; IC50: 12950 nM; Cyclooxygenase-1 (COX-1); 12950.0 nM 3-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one CHEBI:NONE_148683 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19596198 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002442 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one, Cox Inhibitor 7c; IC50: 60.0 nM; Cyclooxygenase-2 (COX-2); 60.0 nM 3-(4-Methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one CHEBI:NONE_148684 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19596198 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002443 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one, Cox Inhibitor 7c; IC50: 16120 nM; Cyclooxygenase-1 (COX-1); 16120.0 nM 3-(4-Methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one CHEBI:NONE_148684 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19596198 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002444 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one, Cox Inhibitor 7d; IC50: 110 nM; Cyclooxygenase-2 (COX-2); 110.0 nM 3-(4-Methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one CHEBI:NONE_148685 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19596198 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002445 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one, Cox Inhibitor 7d; IC50: 14840 nM; Cyclooxygenase-1 (COX-1); 14840.0 nM 3-(4-Methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one CHEBI:NONE_148685 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19596198 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002446 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-Benzyl-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one, Cox Inhibitor 7e; IC50: 70 nM; Cyclooxygenase-2 (COX-2); 70.0 nM 3-Benzyl-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one CHEBI:NONE_148686 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19596198 PENTACON PENTACON Notes: Request ChEBI ID:3-Benzyl-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002447 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-Benzyl-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one, Cox Inhibitor 7e; IC50: 15800 nM; Cyclooxygenase-1 (COX-1); 15800.0 nM 3-Benzyl-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one CHEBI:NONE_148686 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19596198 PENTACON PENTACON Notes: Request ChEBI ID:3-Benzyl-2-(4-methylsulfonylphenyl)-1,3-benzthiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002448 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-Methylsulfonylphenyl)-3-phenethyl-1,3-benzthiazinan-4-one, Cox Inhibitor 7f; IC50: 80 nM; Cyclooxygenase-2 (COX-2); 80.0 nM 2-(4-Methylsulfonylphenyl)-3-phenethyl-1,3-benzthiazinan-4-one CHEBI:NONE_148687 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19596198 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-Methylsulfonylphenyl)-3-phenethyl-1,3-benzthiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002449 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-Methylsulfonylphenyl)-3-phenethyl-1,3-benzthiazinan-4-one, Cox Inhibitor 7f; IC50: 15910 nM; Cyclooxygenase-1 (COX-1); 15910.0 nM 2-(4-Methylsulfonylphenyl)-3-phenethyl-1,3-benzthiazinan-4-one CHEBI:NONE_148687 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19596198 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-Methylsulfonylphenyl)-3-phenethyl-1,3-benzthiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002450 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 60.0 nM; Cyclooxygenase-2 (COX-2); CHEBI:118694 (celecoxib) 60.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19560931 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002451 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 24300.0 nM; Cyclooxygenase-1 (COX-1); CHEBI:118694 (celecoxib) 24300.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19560931 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002452 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(methylsulfonyl)phenyl)-quinoline-4-carboxylic acid, Cox Inhibitor 4; IC50: 91 nM; Cyclooxygenase-2 (COX-2); 91.0 nM 2-(4-(methylsulfonyl)phenyl)-quinoline-4-carboxylic acid CHEBI:NONE_148688 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19560931 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(methylsulfonyl)phenyl)-quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002453 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(methylsulfonyl)phenyl)-quinoline-4-carboxylic acid, Cox Inhibitor 4; IC50: 13400 nM; Cyclooxygenase-1 (COX-1); 13400.0 nM 2-(4-(methylsulfonyl)phenyl)-quinoline-4-carboxylic acid CHEBI:NONE_148688 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19560931 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(methylsulfonyl)phenyl)-quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002454 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 8-Methyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid, Cox Inhibitor 9a; IC50: 86 nM; Cyclooxygenase-2 (COX-2); 86.0 nM 8-Methyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid CHEBI:NONE_148689 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19560931 PENTACON PENTACON Notes: Request ChEBI ID: 8-Methyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002455 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 8-Methyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid, Cox Inhibitor 9a; IC50: 14200 nM; Cyclooxygenase-1 (COX-1); 14200.0 nM 8-Methyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid CHEBI:NONE_148689 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19560931 PENTACON PENTACON Notes: Request ChEBI ID: 8-Methyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002456 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 7,8-Dimethyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid, Cox Inhibitor 9b; IC50: 75 nM; Cyclooxygenase-2 (COX-2); 75.0 nM 7,8-Dimethyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid CHEBI:NONE_148690 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19560931 PENTACON PENTACON Notes: Request ChEBI ID:7,8-Dimethyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002457 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 7,8-Dimethyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid, Cox Inhibitor 9b; IC50: 14500 nM; Cyclooxygenase-1 (COX-1); 14500.0 nM 7,8-Dimethyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid CHEBI:NONE_148690 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19560931 PENTACON PENTACON Notes: Request ChEBI ID: 7,8-Dimethyl-2-(4-(methylsulfonyl)phenyl)quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002458 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(Methylsulfonyl)phenyl)-8-phenyl-quinoline-4-carboxylic acid, Cox Inhibitor 9c; IC50: 71 nM; Cyclooxygenase-2 (COX-2); 71.0 nM 2-(4-(Methylsulfonyl)phenyl)-8-phenyl-quinoline-4-carboxylic acid CHEBI:NONE_148691 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19560931 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(Methylsulfonyl)phenyl)-8-phenyl-quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002459 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(Methylsulfonyl)phenyl)-8-phenyl-quinoline-4-carboxylic acid, Cox Inhibitor 9c; IC50: 14700 nM; Cyclooxygenase-1 (COX-1); 14700.0 nM 2-(4-(Methylsulfonyl)phenyl)-8-phenyl-quinoline-4-carboxylic acid CHEBI:NONE_148691 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19560931 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(Methylsulfonyl)phenyl)-8-phenyl-quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002460 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(Methylsulfonyl)phenyl)benzo[h]quinoline-4-carboxylic acid, Cox Inhibitor 9d; IC50: 54 nM; Cyclooxygenase-2 (COX-2); 54.0 nM 2-(4-(Methylsulfonyl)phenyl)benzo[h]quinoline-4-carboxylic acid CHEBI:NONE_148692 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19560931 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(Methylsulfonyl)phenyl)benzo[h]quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002461 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 2-(4-(Methylsulfonyl)phenyl)benzo[h]quinoline-4-carboxylic acid, Cox Inhibitor 9d; IC50: 17600 nM; Cyclooxygenase-1 (COX-1); 17600.0 nM 2-(4-(Methylsulfonyl)phenyl)benzo[h]quinoline-4-carboxylic acid CHEBI:NONE_148692 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19560931 PENTACON PENTACON Notes: Request ChEBI ID: 2-(4-(Methylsulfonyl)phenyl)benzo[h]quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002462 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 7,8,9,10-Tetrahydro-2-(4-(methylsulfonyl)phenyl)benzo[h]quinoline-4-carboxylic acid, Cox Inhibitor 9e; IC50: 43 nM; Cyclooxygenase-2 (COX-2); 43.0 nM 7,8,9,10-Tetrahydro-2-(4-(methylsulfonyl)phenyl)benzo[h]quinoline-4-carboxylic acid CHEBI:NONE_148693 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19560931 PENTACON PENTACON Notes: Request ChEBI ID: 7,8,9,10-Tetrahydro-2-(4-(methylsulfonyl)phenyl)benzo[h]quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002463 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 7,8,9,10-Tetrahydro-2-(4-(methylsulfonyl)phenyl)benzo[h]quinoline-4-carboxylic acid, Cox Inhibitor 9e; IC50: 22100 nM; Cyclooxygenase-1 (COX-1); 22100.0 nM 7,8,9,10-Tetrahydro-2-(4-(methylsulfonyl)phenyl)benzo[h]quinoline-4-carboxylic acid CHEBI:NONE_148693 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19560931 PENTACON PENTACON Notes: Request ChEBI ID: 7,8,9,10-Tetrahydro-2-(4-(methylsulfonyl)phenyl)benzo[h]quinoline-4-carboxylic acid AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002464 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 60.0 nM; Cyclooxygenase-2 (COX-2); CHEBI:118694 (celecoxib) 60.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19447036 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002465 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 24300.0 nM; Cyclooxygenase-1 (COX-1); CHEBI:118694 (celecoxib) 24300.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19447036 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002466 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-benzyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one, Cox Inhibitor 11a; IC50: 60.0 nM; Cyclooxygenase-2 (COX-2); 60.0 nM 3-benzyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one CHEBI:NONE_148694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19447036 PENTACON PENTACON Notes: Request ChEBI ID: 3-benzyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002467 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-benzyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one, Cox Inhibitor 11a; IC50: 17150 nM; Cyclooxygenase-1 (COX-1); 17150.0 nM 3-benzyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one CHEBI:NONE_148694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19447036 PENTACON PENTACON Notes: Request ChEBI ID: 3-benzyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002468 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-phenethyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one, Cox Inhibitor 11b; IC50: 70 nM; Cyclooxygenase-2 (COX-2); 70.0 nM 3-phenethyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one CHEBI:NONE_148695 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19447036 PENTACON PENTACON Notes: Request ChEBI ID: 3-phenethyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002469 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-phenethyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one, Cox Inhibitor 11b; IC50: 15980 nM; Cyclooxygenase-1 (COX-1); 15980.0 nM 3-phenethyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one CHEBI:NONE_148695 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19447036 PENTACON PENTACON Notes: Request ChEBI ID: 3-phenethyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002470 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-propyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one, Cox Inhibitor 11d; IC50: 110 nM; Cyclooxygenase-2 (COX-2); 110.0 nM 3-propyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one CHEBI:NONE_148696 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19447036 PENTACON PENTACON Notes: Request ChEBI ID: 3-propyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002471 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-propyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one, Cox Inhibitor 11d; IC50: 14120 nM; Cyclooxygenase-1 (COX-1); 14120.0 nM 3-propyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one CHEBI:NONE_148696 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19447036 PENTACON PENTACON Notes: Request ChEBI ID: 3-propyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002472 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-butyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one, Cox Inhibitor 11e; IC50: 80 nM; Cyclooxygenase-2 (COX-2); 80.0 nM 3-butyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one CHEBI:NONE_148697 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19447036 PENTACON PENTACON Notes: Request ChEBI ID: 3-butyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002473 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-butyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one, Cox Inhibitor 11e; IC50: 14800 nM; Cyclooxygenase-1 (COX-1); 14800.0 nM 3-butyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one CHEBI:NONE_148697 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19447036 PENTACON PENTACON Notes: Request ChEBI ID: 3-butyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002474 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-pentyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one, Cox Inhibitor 11f; IC50: 80 nM; Cyclooxygenase-2 (COX-2); 80.0 nM 3-pentyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one CHEBI:NONE_148698 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19447036 PENTACON PENTACON Notes: Request ChEBI ID: 3-pentyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002475 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-pentyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one, Cox Inhibitor 11f; IC50: 14910 nM; Cyclooxygenase-1 (COX-1); 14910.0 nM 3-pentyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one CHEBI:NONE_148698 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:19447036 PENTACON PENTACON Notes: Request ChEBI ID: 3-pentyl-2-(4-methyl sulfonylphenyl)-1,3-thiazinan-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002476 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 60.0 nM; Cyclooxygenase-2 (COX-2); CHEBI:118694 (celecoxib) 60.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:18226898 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002477 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 24300.0 nM; Cyclooxygenase-1 (COX-1); CHEBI:118694 (celecoxib) 24300.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:18226898 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002478 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 1-(4-methylsulfonylpheny)-3-(4-hydroxyphenyl) urea, Cox Inhibitor 4a; IC50: 170 nM; Cyclooxygenase-2 (COX-2); 170.0 nM 1-(4-methylsulfonylpheny)-3-(4-hydroxyphenyl) urea CHEBI:NONE_148699 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:18226898 PENTACON PENTACON Notes: Request ChEBI ID: 1-(4-methylsulfonylpheny)-3-(4-hydroxyphenyl) urea AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002479 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 1-(4-methylsulfonylpheny)-3-(4-hydroxyphenyl) urea, Cox Inhibitor 4a; IC50: 9200 nM; Cyclooxygenase-1 (COX-1); 9200.0 nM 1-(4-methylsulfonylpheny)-3-(4-hydroxyphenyl) urea CHEBI:NONE_148699 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:18226898 PENTACON PENTACON Notes: Request ChEBI ID: 1-(4-methylsulfonylpheny)-3-(4-hydroxyphenyl) urea AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002480 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 1-(4-methylsulfonylpheny)-3-(4-fluorophenyl) urea, Cox Inhibitor 4b; IC50: 130 nM; Cyclooxygenase-2 (COX-2); 130.0 nM 1-(4-methylsulfonylpheny)-3-(4-fluorophenyl) urea CHEBI:NONE_148700 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:18226898 PENTACON PENTACON Notes: Request ChEBI ID: 1-(4-methylsulfonylpheny)-3-(4-fluorophenyl) urea AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002481 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 1-(4-methylsulfonylpheny)-3-(4-fluorophenyl) urea, Cox Inhibitor 4b; IC50: 21800 nM; Cyclooxygenase-1 (COX-1); 21800.0 nM 1-(4-methylsulfonylpheny)-3-(4-fluorophenyl) urea CHEBI:NONE_148700 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:18226898 PENTACON PENTACON Notes: Request ChEBI ID: 1-(4-methylsulfonylpheny)-3-(4-fluorophenyl) urea AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002482 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 1-(4-methylsulfonylpheny)-3-(4-chlorophenyl) urea, Cox Inhibitor 4c; IC50: 270 nM; Cyclooxygenase-2 (COX-2); 270.0 nM 1-(4-methylsulfonylpheny)-3-(4-chlorophenyl) urea CHEBI:NONE_148701 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:18226898 PENTACON PENTACON Notes: Request ChEBI ID: 1-(4-methylsulfonylpheny)-3-(4-chlorophenyl) urea AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002483 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 1-(4-methylsulfonylpheny)-3-(4-chlorophenyl) urea, Cox Inhibitor 4c; IC50: 21500 nM; Cyclooxygenase-1 (COX-1); 21500.0 nM 1-(4-methylsulfonylpheny)-3-(4-chlorophenyl) urea CHEBI:NONE_148701 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:18226898 PENTACON PENTACON Notes: Request ChEBI ID: 1-(4-methylsulfonylpheny)-3-(4-chlorophenyl) urea AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002484 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 1-(4-methylsulfonylpheny)-3-(4-methylphenyl) urea, Cox Inhibitor 4d; IC50: 330 nM; Cyclooxygenase-2 (COX-2); 330.0 nM 1-(4-methylsulfonylpheny)-3-(4-methylphenyl) urea CHEBI:NONE_148702 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:18226898 PENTACON PENTACON Notes: Request ChEBI ID: 1-(4-methylsulfonylpheny)-3-(4-methylphenyl) urea AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002485 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 1-(4-methylsulfonylpheny)-3-(4-methylphenyl) urea, Cox Inhibitor 4d; IC50: 12500 nM; Cyclooxygenase-1 (COX-1); 12500.0 nM 1-(4-methylsulfonylpheny)-3-(4-methylphenyl) urea CHEBI:NONE_148702 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:18226898 PENTACON PENTACON Notes: Request ChEBI ID: 1-(4-methylsulfonylpheny)-3-(4-methylphenyl) urea AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002486 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 1-(4-methylsulfonylpheny)-3-(4-methoxyphenyl) urea, Cox Inhibitor 4e; IC50: 110 nM; Cyclooxygenase-2 (COX-2); 110.0 nM 1-(4-methylsulfonylpheny)-3-(4-methoxyphenyl) urea CHEBI:NONE_148703 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:18226898 PENTACON PENTACON Notes: Request ChEBI ID:1-(4-methylsulfonylpheny)-3-(4-methoxyphenyl) urea AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002487 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 1-(4-methylsulfonylpheny)-3-(4-methoxyphenyl) urea, Cox Inhibitor 4e; IC50: 22400 nM; Cyclooxygenase-1 (COX-1); 22400.0 nM 1-(4-methylsulfonylpheny)-3-(4-methoxyphenyl) urea CHEBI:NONE_148703 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:18226898 PENTACON PENTACON Notes: Request ChEBI ID: 1-(4-methylsulfonylpheny)-3-(4-methoxyphenyl) urea AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002488 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 60.0 nM; Cyclooxygenase-2 (COX-2); CHEBI:118694 (celecoxib) 60.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002489 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 24300.0 nM; Cyclooxygenase-1 (COX-1); CHEBI:118694 (celecoxib) 24300.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002490 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-(Methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one, Cox Inhibitor 3a; IC50: 110 nM; Cyclooxygenase-2 (COX-2); 110.0 nM (E)-1-(4-(Methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one CHEBI:NONE_148704 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-(Methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002491 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-(Methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one, Cox Inhibitor 3a; IC50: 13270 nM; Cyclooxygenase-1 (COX-1); 13270.0 nM (E)-1-(4-(Methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one CHEBI:NONE_148704 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-(Methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002492 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (Z)-1-(4-(Methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one, Cox Inhibitor 3b; IC50: 70 nM; Cyclooxygenase-2 (COX-2); 70.0 nM (Z)-1-(4-(Methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one CHEBI:NONE_148705 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (Z)-1-(4-(Methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002493 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (Z)-1-(4-(Methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one, Cox Inhibitor 3b; IC50: 14270 nM; Cyclooxygenase-1 (COX-1); 14270.0 nM (Z)-1-(4-(Methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one CHEBI:NONE_148705 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (Z)-1-(4-(Methylsulfonyl)phenyl)-2,3-diphenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002494 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one, Cox Inhibitor 4a; IC50: 190 nM; Cyclooxygenase-2 (COX-2); 190.0 nM (E)-3-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one CHEBI:NONE_148706 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002495 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one, Cox Inhibitor 4a; IC50: 12590 nM; Cyclooxygenase-1 (COX-1); 12590.0 nM (E)-3-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one CHEBI:NONE_148706 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002496 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (Z)-3-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one, Cox Inhibitor 4b; IC50: 160 nM; Cyclooxygenase-2 (COX-2); 160.0 nM (Z)-3-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one CHEBI:NONE_148707 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (Z)-3-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002497 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (Z)-3-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one, Cox Inhibitor 4b; IC50: 30940 nM; Cyclooxygenase-1 (COX-1); 30940.0 nM (Z)-3-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one CHEBI:NONE_148707 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (Z)-3-(4-Fluorophenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002498 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-p-tolylprop-2-en-1-one, Cox Inhibitor 5a; IC50: 280 nM; Cyclooxygenase-2 (COX-2); 280.0 nM (E)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-p-tolylprop-2-en-1-one CHEBI:NONE_148708 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID:(E)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-p-tolylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002499 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-p-tolylprop-2-en-1-one, Cox Inhibitor 5a; IC50: 10370 nM; Cyclooxygenase-1 (COX-1); 10370.0 nM (E)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-p-tolylprop-2-en-1-one CHEBI:NONE_148708 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-p-tolylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002500 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (Z)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-p-tolylprop-2-en-1-one, Cox Inhibitor 5b; IC50: 210 nM; Cyclooxygenase-2 (COX-2); 210.0 nM (Z)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-p-tolylprop-2-en-1-one CHEBI:NONE_148709 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (Z)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-p-tolylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002501 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (Z)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-p-tolylprop-2-en-1-one, Cox Inhibitor 5b; IC50: 12210 nM; Cyclooxygenase-1 (COX-1); 12210.0 nM (Z)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-p-tolylprop-2-en-1-one CHEBI:NONE_148709 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (Z)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-p-tolylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002502 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one, Cox Inhibitor 6a; IC50: 220 nM; Cyclooxygenase-2 (COX-2); 220.0 nM (E)-3-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one CHEBI:NONE_148710 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002503 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one, Cox Inhibitor 6a; IC50: 10680 nM; Cyclooxygenase-1 (COX-1); 10680.0 nM (E)-3-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one CHEBI:NONE_148710 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002504 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (Z)-3-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one, Cox Inhibitor 6b; IC50: 210 nM; Cyclooxygenase-2 (COX-2); 210.0 nM (Z)-3-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one CHEBI:NONE_148711 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (Z)-3-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002505 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (Z)-3-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one, Cox Inhibitor 6b; IC50: 18380 nM; Cyclooxygenase-1 (COX-1); 18380.0 nM (Z)-3-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one CHEBI:NONE_148711 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (Z)-3-(4-Methoxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002506 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Hydroxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one, Cox Inhibitor 7; IC50: 80 nM; Cyclooxygenase-2 (COX-2); 80.0 nM (E)-3-(4-Hydroxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one CHEBI:NONE_148712 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Hydroxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002507 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Hydroxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one, Cox Inhibitor 7; IC50: 14420 nM; Cyclooxygenase-1 (COX-1); 14420.0 nM (E)-3-(4-Hydroxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one CHEBI:NONE_148712 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Hydroxyphenyl)-1-(4-(methylsulfonyl)phenyl)-2-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002508 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-(thiophen-2-yl)prop-2-en-1-one, Cox Inhibitor 8a; IC50: 130 nM; Cyclooxygenase-2 (COX-2); 130.0 nM (E)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-(thiophen-2-yl)prop-2-en-1-one CHEBI:NONE_148713 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-(thiophen-2-yl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002509 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-(thiophen-2-yl)prop-2-en-1-one, Cox Inhibitor 8a; IC50: 13120 nM; Cyclooxygenase-1 (COX-1); 13120.0 nM (E)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-(thiophen-2-yl)prop-2-en-1-one CHEBI:NONE_148713 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-(thiophen-2-yl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002510 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E & Z)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-(pyridin-4-yl)prop-2-en-1-one, Cox Inhibitor 9; IC50: 70 nM; Cyclooxygenase-2 (COX-2); 70.0 nM (E & Z)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-(pyridin-4-yl)prop-2-en-1-one CHEBI:NONE_148714 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (E & Z)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-(pyridin-4-yl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002511 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E & Z)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-(pyridin-4-yl)prop-2-en-1-one, Cox Inhibitor 9; IC50: 12370 nM; Cyclooxygenase-1 (COX-1); 12370.0 nM (E & Z)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-(pyridin-4-yl)prop-2-en-1-one CHEBI:NONE_148714 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:20691338 PENTACON PENTACON Notes: Request ChEBI ID: (E & Z)-1-(4-(Methylsulfonyl)phenyl)-2-phenyl-3-(pyridin-4-yl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002512 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 60.0 nM; Cyclooxygenase-2 (COX-2); CHEBI:118694 (celecoxib) 60.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17822894 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002513 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Celecoxib; IC50: 24300.0 nM; Cyclooxygenase-1 (COX-1); CHEBI:118694 (celecoxib) 24300.0 nM celecoxib CHEBI:118694 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17822894 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002514 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-hydroxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one, Cox Inhibitor 5a; IC50: 20 nM; Cyclooxygenase-2 (COX-2); 20.0 nM 3-(4-hydroxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one CHEBI:NONE_148715 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17822894 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-hydroxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002515 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-hydroxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one, Cox Inhibitor 5a; IC50: 96100 nM; Cyclooxygenase-1 (COX-1); 96100.0 nM 3-(4-hydroxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one CHEBI:NONE_148715 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17822894 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-hydroxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002516 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one, Cox Inhibitor 5b; IC50: 120 nM; Cyclooxygenase-2 (COX-2); 120.0 nM 3-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one CHEBI:NONE_148716 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17822894 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002517 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one, Cox Inhibitor 5b; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM 3-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one CHEBI:NONE_148716 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17822894 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-fluorophenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002518 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one, Cox Inhibitor 5c; IC50: 150 nM; Cyclooxygenase-2 (COX-2); 150.0 nM 3-(4-methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one CHEBI:NONE_148717 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17822894 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002519 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one, Cox Inhibitor 5c; IC50: 53900 nM; Cyclooxygenase-1 (COX-1); 53900.0 nM 3-(4-methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one CHEBI:NONE_148717 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17822894 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-methylphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002520 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one, Cox Inhibitor 5d; IC50: 160 nM; Cyclooxygenase-2 (COX-2); 160.0 nM 3-(4-methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one CHEBI:NONE_148718 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17822894 PENTACON PENTACON Notes: Request ChEBI ID:3-(4-methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002521 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one, Cox Inhibitor 5d; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM 3-(4-methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one CHEBI:NONE_148718 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17822894 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-methoxyphenyl)-2-(4-methylsulfonylphenyl)-1,3-thiazolidine-4-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002522 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Rofecoxib; IC50: 430 nM; Cyclooxygenase-2 (COX-2); CHEBI:8887 (rofecoxib) 430.0 nM rofecoxib CHEBI:8887 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17706175 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002523 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Rofecoxib; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); CHEBI:8887 (rofecoxib) nM rofecoxib CHEBI:8887 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17706175 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002524 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 acetylsalicylic acid; IC50: 2400 nM; Cyclooxygenase-2 (COX-2); CHEBI:15365 (acetylsalicylic acid) 2400.0 nM acetylsalicylic acid CHEBI:15365 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17706175 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002525 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 acetylsalicylic acid; IC50: 350 nM; Cyclooxygenase-1 (COX-1); CHEBI:15365 (acetylsalicylic acid) 350.0 nM acetylsalicylic acid CHEBI:15365 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17706175 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002526 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-Acetylsulfonamido)phenyl]-3-phenyl-2(5H)furanone, Cox Inhibitor 8a; IC50: 320 nM; Cyclooxygenase-2 (COX-2); 320.0 nM 4-[4-(N-Acetylsulfonamido)phenyl]-3-phenyl-2(5H)furanone CHEBI:NONE_148719 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17706175 PENTACON PENTACON Notes: Request ChEBI ID: 4-[4-(N-Acetylsulfonamido)phenyl]-3-phenyl-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002527 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-Acetylsulfonamido)phenyl]-3-phenyl-2(5H)furanone, Cox Inhibitor 8a; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM 4-[4-(N-Acetylsulfonamido)phenyl]-3-phenyl-2(5H)furanone CHEBI:NONE_148719 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17706175 PENTACON PENTACON Notes: Request ChEBI ID: 4-[4-(N-Acetylsulfonamido)phenyl]-3-phenyl-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002528 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-flourophenyl)-2(5H)furanone, Cox Inhibitor 8b; IC50: 1030 nM; Cyclooxygenase-2 (COX-2); 1030.0 nM 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-flourophenyl)-2(5H)furanone CHEBI:NONE_148720 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17706175 PENTACON PENTACON Notes: Request ChEBI ID: 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-flourophenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002529 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-flourophenyl)-2(5H)furanone, Cox Inhibitor 8b; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-flourophenyl)-2(5H)furanone CHEBI:NONE_148720 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17706175 PENTACON PENTACON Notes: Request ChEBI ID: 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-flourophenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002530 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-chlorophenyl)-2(5H)furanone, Cox Inhibitor 8c; IC50: 4480 nM; Cyclooxygenase-2 (COX-2); 4480.0 nM 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-chlorophenyl)-2(5H)furanone CHEBI:NONE_148721 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17706175 PENTACON PENTACON Notes: Request ChEBI ID: 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-chlorophenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002531 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-chlorophenyl)-2(5H)furanone, Cox Inhibitor 8c; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-chlorophenyl)-2(5H)furanone CHEBI:NONE_148721 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17706175 PENTACON PENTACON Notes: Request ChEBI ID: 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-chlorophenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002532 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methylphenyl)-2(5H)furanone, Cox Inhibitor 8d; IC50: 4850 nM; Cyclooxygenase-2 (COX-2); 4850.0 nM 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methylphenyl)-2(5H)furanone CHEBI:NONE_148722 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17706175 PENTACON PENTACON Notes: Request ChEBI ID: 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methylphenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002533 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methylphenyl)-2(5H)furanone, Cox Inhibitor 8d; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methylphenyl)-2(5H)furanone CHEBI:NONE_148722 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17706175 PENTACON PENTACON Notes: Request ChEBI ID: 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methylphenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002534 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methoxylphenyl)-2(5H)furanone, Cox Inhibitor 8e; IC50: 9970 nM; Cyclooxygenase-2 (COX-2); 9970.0 nM 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methoxylphenyl)-2(5H)furanone CHEBI:NONE_148723 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17706175 PENTACON PENTACON Notes: Request ChEBI ID: 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methoxylphenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002535 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methoxylphenyl)-2(5H)furanone, Cox Inhibitor 8e; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methoxylphenyl)-2(5H)furanone CHEBI:NONE_148723 arachidonic acid CHEBI:15843 Y Y ECO:0000006 PubMed:17706175 PENTACON PENTACON Notes: Request ChEBI ID: 4-[4-(N-Acetylsulfonamido)phenyl]-3-(4-methoxylphenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002536 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Rofecoxib; IC50: 500 nM; Cyclooxygenase-2 (COX-2); CHEBI:8887 (rofecoxib) 500.0 nM rofecoxib CHEBI:8887 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:17067801 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002537 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Rofecoxib; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); CHEBI:8887 (rofecoxib) nM rofecoxib CHEBI:8887 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:17067801 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002538 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-(4-Methylsulfonamidophenyl)-3-phenyl-2(5H)furanone, Cox Inhibitor 11a; IC50: 1700 nM; Cyclooxygenase-2 (COX-2); 1700.0 nM 4-(4-Methylsulfonamidophenyl)-3-phenyl-2(5H)furanone CHEBI:NONE_148724 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:17067801 PENTACON PENTACON Notes: Request ChEBI ID: 4-(4-Methylsulfonamidophenyl)-3-phenyl-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002539 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-(4-Methylsulfonamidophenyl)-3-phenyl-2(5H)furanone, Cox Inhibitor 11a; IC50: 31600 nM; Cyclooxygenase-1 (COX-1); 31600.0 nM 4-(4-Methylsulfonamidophenyl)-3-phenyl-2(5H)furanone CHEBI:NONE_148724 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:17067801 PENTACON PENTACON Notes: Request ChEBI ID: 4-(4-Methylsulfonamidophenyl)-3-phenyl-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002540 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Fluorophenyl)-4-(4-methylsulfonamidophenyl)- 2(5H)furanone, Cox Inhibitor 11b; IC50: 3200 nM; Cyclooxygenase-2 (COX-2); 3200.0 nM 3-(4-Fluorophenyl)-4-(4-methylsulfonamidophenyl)- 2(5H)furanone CHEBI:NONE_148725 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:17067801 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Fluorophenyl)-4-(4-methylsulfonamidophenyl)- 2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002541 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Fluorophenyl)-4-(4-methylsulfonamidophenyl)- 2(5H)furanone, Cox Inhibitor 11b; IC50: 10000 nM; Cyclooxygenase-1 (COX-1); 10000.0 nM 3-(4-Fluorophenyl)-4-(4-methylsulfonamidophenyl)- 2(5H)furanone CHEBI:NONE_148725 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:17067801 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Fluorophenyl)-4-(4-methylsulfonamidophenyl)- 2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002542 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Chlorophenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone, Cox Inhibitor 11c; IC50: 800 nM; Cyclooxygenase-2 (COX-2); 800.0 nM 3-(4-Chlorophenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone CHEBI:NONE_148726 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:17067801 PENTACON PENTACON Notes: Request ChEBI ID:3-(4-Chlorophenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002543 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Chlorophenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone, Cox Inhibitor 11c; IC50: 31500 nM; Cyclooxygenase-1 (COX-1); 31500.0 nM 3-(4-Chlorophenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone CHEBI:NONE_148726 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:17067801 PENTACON PENTACON Notes: Request ChEBI ID:3-(4-Chlorophenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002544 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Bromophenyl)-4-(4-methylsulfonamidophenyl)- 2(5H)furanone, Cox Inhibitor 11d; IC50: 3200 nM; Cyclooxygenase-2 (COX-2); 3200.0 nM 3-(4-Bromophenyl)-4-(4-methylsulfonamidophenyl)- 2(5H)furanone CHEBI:NONE_148727 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:17067801 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Bromophenyl)-4-(4-methylsulfonamidophenyl)- 2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002545 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Bromophenyl)-4-(4-methylsulfonamidophenyl)- 2(5H)furanone, Cox Inhibitor 11d; IC50: 35500 nM; Cyclooxygenase-1 (COX-1); 35500.0 nM 3-(4-Bromophenyl)-4-(4-methylsulfonamidophenyl)- 2(5H)furanone CHEBI:NONE_148727 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:17067801 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Bromophenyl)-4-(4-methylsulfonamidophenyl)- 2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002546 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Methylphenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone, Cox Inhibitor 11e; IC50: 900 nM; Cyclooxygenase-2 (COX-2); 900.0 nM 3-(4-Methylphenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone CHEBI:NONE_148728 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:17067801 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Methylphenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002547 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Request ChEBI ID: 3-(4-Methylphenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone, Cox Inhibitor 11e; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM 3-(4-Methylphenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone CHEBI:NONE_148728 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:17067801 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Methylphenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002548 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Methoxyphenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone, Cox Inhibitor 11f; IC50: 31500 nM; Cyclooxygenase-2 (COX-2); 31500.0 nM 3-(4-Methoxyphenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone CHEBI:NONE_148729 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:17067801 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Methoxyphenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002549 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 3-(4-Methoxyphenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone, Cox Inhibitor 11f; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM 3-(4-Methoxyphenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone CHEBI:NONE_148729 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:17067801 PENTACON PENTACON Notes: Request ChEBI ID: 3-(4-Methoxyphenyl)-4-(4-methylsulfonamidophenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002550 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Rofecoxib; IC50: 500 nM; Cyclooxygenase-2 (COX-2); CHEBI:8887 (rofecoxib) 500.0 nM rofecoxib CHEBI:8887 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002551 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Rofecoxib; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); CHEBI:8887 (rofecoxib) nM rofecoxib CHEBI:8887 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002552 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Methanesulfonamidophenyl)-3-phenylprop-2-en-1-one, Cox Inhibitor 7a; IC50: 3200 nM; Cyclooxygenase-2 (COX-2); 3200.0 nM (E)-1-(4-Methanesulfonamidophenyl)-3-phenylprop-2-en-1-one CHEBI:NONE_148730 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Methanesulfonamidophenyl)-3-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002553 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Methanesulfonamidophenyl)-3-phenylprop-2-en-1-one, Cox Inhibitor 7a; IC50: 3000 nM; Cyclooxygenase-1 (COX-1); 3000.0 nM (E)-1-(4-Methanesulfonamidophenyl)-3-phenylprop-2-en-1-one CHEBI:NONE_148730 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Methanesulfonamidophenyl)-3-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002554 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Methanesulfonamidophenyl)-3-(4-methylphenyl)prop-2-en-1-one, Cox Inhibitor 7b; IC50: 1000 nM; Cyclooxygenase-2 (COX-2); 1000.0 nM (E)-1-(4-Methanesulfonamidophenyl)-3-(4-methylphenyl)prop-2-en-1-one CHEBI:NONE_148731 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Methanesulfonamidophenyl)-3-(4-methylphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002555 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Methanesulfonamidophenyl)-3-(4-methylphenyl)prop-2-en-1-one, Cox Inhibitor 7b; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM (E)-1-(4-Methanesulfonamidophenyl)-3-(4-methylphenyl)prop-2-en-1-one CHEBI:NONE_148731 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Methanesulfonamidophenyl)-3-(4-methylphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002556 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Fluorophenyl)-1-(4-methanesulfonamidophenyl)prop-2-en-1-one, Cox Inhibitor 7c; IC50: >100000 nM; Cyclooxygenase-2 (COX-2); nM (E)-3-(4-Fluorophenyl)-1-(4-methanesulfonamidophenyl)prop-2-en-1-one CHEBI:NONE_148732 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Fluorophenyl)-1-(4-methanesulfonamidophenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002557 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Fluorophenyl)-1-(4-methanesulfonamidophenyl)prop-2-en-1-one, Cox Inhibitor 7c; IC50: 3300 nM; Cyclooxygenase-1 (COX-1); 3300.0 nM (E)-3-(4-Fluorophenyl)-1-(4-methanesulfonamidophenyl)prop-2-en-1-one CHEBI:NONE_148732 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Fluorophenyl)-1-(4-methanesulfonamidophenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002558 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Methanesulfonamidophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one, Cox Inhibitor 7d; IC50: 10000 nM; Cyclooxygenase-2 (COX-2); 10000.0 nM (E)-1-(4-Methanesulfonamidophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one CHEBI:NONE_148733 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Methanesulfonamidophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002559 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Methanesulfonamidophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one, Cox Inhibitor 7d; IC50: 1000 nM; Cyclooxygenase-1 (COX-1); 1000.0 nM (E)-1-(4-Methanesulfonamidophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one CHEBI:NONE_148733 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Methanesulfonamidophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002560 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Azidophenyl)-3-phenylprop-2-en-1-one, Cox Inhibitor 7e; IC50: 3400 nM; Cyclooxygenase-2 (COX-2); 3400.0 nM (E)-1-(4-Azidophenyl)-3-phenylprop-2-en-1-one CHEBI:NONE_148734 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Azidophenyl)-3-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002561 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Azidophenyl)-3-phenylprop-2-en-1-one, Cox Inhibitor 7e; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM (E)-1-(4-Azidophenyl)-3-phenylprop-2-en-1-one CHEBI:NONE_148734 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Azidophenyl)-3-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002562 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one, Cox Inhibitor 7f; IC50: 300 nM; Cyclooxygenase-2 (COX-2); 300.0 nM (E)-1-(4-Azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one CHEBI:NONE_148735 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002563 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one, Cox Inhibitor 7f; IC50: 22200 nM; Cyclooxygenase-1 (COX-1); 22200.0 nM (E)-1-(4-Azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one CHEBI:NONE_148735 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Azidophenyl)-3-(4-methylphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002564 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Azidophenyl)-3-(4-fluorophenyl)prop-2-en-1-one, Cox Inhibitor 7g; IC50: 10000 nM; Cyclooxygenase-2 (COX-2); 10000.0 nM (E)-1-(4-Azidophenyl)-3-(4-fluorophenyl)prop-2-en-1-one CHEBI:NONE_148736 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Azidophenyl)-3-(4-fluorophenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002565 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Azidophenyl)-3-(4-fluorophenyl)prop-2-en-1-one, Cox Inhibitor 7g; IC50: 4200 nM; Cyclooxygenase-1 (COX-1); 4200.0 nM (E)-1-(4-Azidophenyl)-3-(4-fluorophenyl)prop-2-en-1-one CHEBI:NONE_148736 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Azidophenyl)-3-(4-fluorophenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002566 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Azidophenyl)-3-(4-methoxyphenyl)prop-2-ene-1-one, Cox Inhibitor 7h; IC50: 3600 nM; Cyclooxygenase-2 (COX-2); 3600.0 nM (E)-1-(4-Azidophenyl)-3-(4-methoxyphenyl)prop-2-ene-1-one CHEBI:NONE_148737 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Azidophenyl)-3-(4-methoxyphenyl)prop-2-ene-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002567 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Azidophenyl)-3-(4-methoxyphenyl)prop-2-ene-1-one, Cox Inhibitor 7h; IC50: 400 nM; Cyclooxygenase-1 (COX-1); 400.0 nM (E)-1-(4-Azidophenyl)-3-(4-methoxyphenyl)prop-2-ene-1-one CHEBI:NONE_148737 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16798002 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Azidophenyl)-3-(4-methoxyphenyl)prop-2-ene-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002568 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Rofecoxib; IC50: 500 nM; Cyclooxygenase-2 (COX-2); CHEBI:8887 (rofecoxib) 500.0 nM rofecoxib CHEBI:8887 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002569 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Rofecoxib; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); CHEBI:8887 (rofecoxib) nM rofecoxib CHEBI:8887 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002570 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Methanesulfonylphenyl)-1-phenylprop-2-en-1-one, Cox Inhibitor 9a; IC50: 800 nM; Cyclooxygenase-2 (COX-2); 800.0 nM (E)-3-(4-Methanesulfonylphenyl)-1-phenylprop-2-en-1-one CHEBI:NONE_148738 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Methanesulfonylphenyl)-1-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002571 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Methanesulfonylphenyl)-1-phenylprop-2-en-1-one, Cox Inhibitor 9a; IC50:1100 nM; Cyclooxygenase-1 (COX-1); 1100.0 nM (E)-3-(4-Methanesulfonylphenyl)-1-phenylprop-2-en-1-one CHEBI:NONE_148738 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Methanesulfonylphenyl)-1-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002572 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Methanesulfonylphenyl)-1-(4-methylphenyl)prop-2-en-1-one, Cox Inhibitor 9b; IC50: 300 nM; Cyclooxygenase-2 (COX-2); 300.0 nM (E)-3-(4-Methanesulfonylphenyl)-1-(4-methylphenyl)prop-2-en-1-one CHEBI:NONE_148739 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Methanesulfonylphenyl)-1-(4-methylphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002573 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Methanesulfonylphenyl)-1-(4-methylphenyl)prop-2-en-1-one, Cox Inhibitor 9b; IC50: 1000 nM; Cyclooxygenase-1 (COX-1); 1000.0 nM (E)-3-(4-Methanesulfonylphenyl)-1-(4-methylphenyl)prop-2-en-1-one CHEBI:NONE_148739 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Methanesulfonylphenyl)-1-(4-methylphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002574 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Fluorophenyl)-3-(4-methanesulfonylphenyl)prop-2-en-1-one, Cox Inhibitor 9c; IC50: 10000 nM; Cyclooxygenase-2 (COX-2); 10000.0 nM (E)-1-(4-Fluorophenyl)-3-(4-methanesulfonylphenyl)prop-2-en-1-one CHEBI:NONE_148740 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Fluorophenyl)-3-(4-methanesulfonylphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002575 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Fluorophenyl)-3-(4-methanesulfonylphenyl)prop-2-en-1-one, Cox Inhibitor 9c; IC50: 4200 nM; Cyclooxygenase-1 (COX-1); 4200.0 nM (E)-1-(4-Fluorophenyl)-3-(4-methanesulfonylphenyl)prop-2-en-1-one CHEBI:NONE_148740 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Fluorophenyl)-3-(4-methanesulfonylphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002576 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Methanesulfonylphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one, Cox Inhibitor 9d; IC50: 4900 nM; Cyclooxygenase-2 (COX-2); 4900.0 nM (E)-3-(4-Methanesulfonylphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one CHEBI:NONE_148741 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Methanesulfonylphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002577 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Methanesulfonylphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one, Cox Inhibitor 9d; IC50: 3200 nM; Cyclooxygenase-1 (COX-1); 3200.0 nM (E)-3-(4-Methanesulfonylphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one CHEBI:NONE_148741 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Methanesulfonylphenyl)-1-(4-methoxyphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002578 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Methanesulfonylphenyl)-3-phenylprop-2-en-1-one, Cox Inhibitor 9e; IC50: 1000 nM; Cyclooxygenase-2 (COX-2); 1000.0 nM (E)-1-(4-Methanesulfonylphenyl)-3-phenylprop-2-en-1-one CHEBI:NONE_148742 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Methanesulfonylphenyl)-3-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002579 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Methanesulfonylphenyl)-3-phenylprop-2-en-1-one, Cox Inhibitor 9e; IC50: 21500 nM; Cyclooxygenase-1 (COX-1); 21500.0 nM (E)-1-(4-Methanesulfonylphenyl)-3-phenylprop-2-en-1-one CHEBI:NONE_148742 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Methanesulfonylphenyl)-3-phenylprop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002580 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Methanesulfonylphenyl)-3-(4-methylphenyl)prop-2-en-1-one, Cox Inhibitor 9f; IC50: 300 nM; Cyclooxygenase-2 (COX-2); 300.0 nM (E)-1-(4-Methanesulfonylphenyl)-3-(4-methylphenyl)prop-2-en-1-one CHEBI:NONE_148743 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Methanesulfonylphenyl)-3-(4-methylphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002581 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Methanesulfonylphenyl)-3-(4-methylphenyl)prop-2-en-1-one, Cox Inhibitor 9f; IC50: 32000 nM; Cyclooxygenase-1 (COX-1); 32000.0 nM (E)-1-(4-Methanesulfonylphenyl)-3-(4-methylphenyl)prop-2-en-1-one CHEBI:NONE_148743 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Methanesulfonylphenyl)-3-(4-methylphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002582 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Fluorophenyl)-1-(4-methanesulfonylphenyl)prop-2-en-1-one, Cox Inhibitor 9g; IC50: 600 nM; Cyclooxygenase-2 (COX-2); 600.0 nM (E)-3-(4-Fluorophenyl)-1-(4-methanesulfonylphenyl)prop-2-en-1-one CHEBI:NONE_148744 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Fluorophenyl)-1-(4-methanesulfonylphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002583 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-3-(4-Fluorophenyl)-1-(4-methanesulfonylphenyl)prop-2-en-1-one, Cox Inhibitor 9g; IC50: 31600 nM; Cyclooxygenase-1 (COX-1); 31600.0 nM (E)-3-(4-Fluorophenyl)-1-(4-methanesulfonylphenyl)prop-2-en-1-one CHEBI:NONE_148744 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-3-(4-Fluorophenyl)-1-(4-methanesulfonylphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002584 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Methanesulfonylphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one, Cox Inhibitor 9h; IC50: 3200 nM; Cyclooxygenase-2 (COX-2); 3200.0 nM (E)-1-(4-Methanesulfonylphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one CHEBI:NONE_148745 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Methanesulfonylphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002585 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 (E)-1-(4-Methanesulfonylphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one, Cox Inhibitor 9h; IC50: 3300 nM; Cyclooxygenase-1 (COX-1); 3300.0 nM (E)-1-(4-Methanesulfonylphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one CHEBI:NONE_148745 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:16356730 PENTACON PENTACON Notes: Request ChEBI ID: (E)-1-(4-Methanesulfonylphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002586 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Rofecoxib; IC50: 430 nM; Cyclooxygenase-2 (COX-2); CHEBI:8887 (rofecoxib) 430.0 nM rofecoxib CHEBI:8887 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:15050636 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002587 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Rofecoxib; IC50: >500000 nM; Cyclooxygenase-1 (COX-1); CHEBI:8887 (rofecoxib) nM rofecoxib CHEBI:8887 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:15050636 PENTACON Added by PENTACON AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002588 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-sulfonylmethylphenyl]-3-(4-(N-sulfonamido)phenyl)-2(5H)furanone, Cox Inhibitor 8a; IC50: >100000 nM; Cyclooxygenase-2 (COX-2); nM 4-[4-(N-sulfonylmethylphenyl\]-3-(4-(N-sulfonamido)phenyl)-2(5H)furanone CHEBI:NONE_148746 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:15050636 PENTACON PENTACON Notes: Request Chebi ID: 4-[4-(N-sulfonylmethylphenyl\]-3-(4-(N-sulfonamido)phenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002589 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-sulfonylmethylphenyl]-3-(4-(N-sulfonamido)phenyl)-2(5H)furanoneCox Inhibitor 8a; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM 4-[4-(N-sulfonylmethylphenyl\]-3-(4-(N-sulfonamido)phenyl)-2(5H)furanone CHEBI:NONE_148746 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:15050636 PENTACON PENTACON Notes: Request Chebi ID: 4-[4-(N-sulfonylmethylphenyl\]-3-(4-(N-sulfonamido)phenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002590 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-sulfonamido)phenyl]-3-(4-(N-sulfonylmethylphenyl)-2(5H)furanone, Cox Inhibitor 8b; IC50: >100000 nM; Cyclooxygenase-2 (COX-2); nM 4-[4-(N-sulfonamido)phenyl]-3-(4-(N-sulfonylmethylphenyl)-2(5H)furanone CHEBI:NONE_148747 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:15050636 PENTACON PENTACON Notes: Request Chebi ID: 4-[4-(N-sulfonamido)phenyl]-3-(4-(N-sulfonylmethylphenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002591 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-sulfonamido)phenyl]-3-(4-(N-sulfonylmethylphenyl)-2(5H)furanone, Cox Inhibitor 8b; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM 4-[4-(N-sulfonamido)phenyl]-3-(4-(N-sulfonylmethylphenyl)-2(5H)furanone CHEBI:NONE_148747 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:15050636 PENTACON PENTACON Notes: Request Chebi ID: 4-[4-(N-sulfonamido)phenyl]-3-(4-(N-sulfonylmethylphenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002592 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-methanesulfonylphenyl]-3-(4-(N-acetylsulfonamido)phenyl)-2(5H)furanone, Cox Inhibitor 9a; IC50: 4600 nM; Cyclooxygenase-2 (COX-2); 4600.0 nM 4-[4-(N-methanesulfonylphenyl]-3-(4-(N-acetylsulfonamido)phenyl)-2(5H)furanone CHEBI:NONE_148748 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:15050636 PENTACON PENTACON Notes: Request Chebi ID: 4-[4-(N-methanesulfonylphenyl]-3-(4-(N-acetylsulfonamido)phenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002593 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-methanesulfonylphenyl]-3-(4-(N-acetylsulfonamido)phenyl)-2(5H)furanone, Cox Inhibitor 9a; IC50: 3200 nM; Cyclooxygenase-1 (COX-1); 3200.0 nM 4-[4-(N-methanesulfonylphenyl]-3-(4-(N-acetylsulfonamido)phenyl)-2(5H)furanone CHEBI:NONE_148748 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:15050636 PENTACON PENTACON Notes: Request Chebi ID: 4-[4-(N-methanesulfonylphenyl]-3-(4-(N-acetylsulfonamido)phenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002594 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone, Cox Inhibitor 9b; IC50: 50 nM; Cyclooxygenase-2 (COX-2); 50.0 nM 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone CHEBI:NONE_148749 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:15050636 PENTACON PENTACON Notes: Request ChEBI ID: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002595 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone, Cox Inhibitor 9b; IC50: >100000 nM; Cyclooxygenase-1 (COX-1); nM 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone CHEBI:NONE_148749 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:15050636 PENTACON PENTACON Notes: Request ChEBI ID: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002596 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-sulfonylmethyl)phenyl]-3-(4-sulfonylazidophenyl)-2(5H)furanone, Cox Inhibitor 10a; IC50: 11000 nM; Cyclooxygenase-2 (COX-2); 11000.0 nM 4-[4-(N-sulfonylmethyl)phenyl]-3-(4-sulfonylazidophenyl)-2(5H)furanone CHEBI:NONE_148750 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:15050636 PENTACON PENTACON Notes: Request Chebi ID: 4-[4-(N-sulfonylmethyl)phenyl]-3-(4-sulfonylazidophenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002597 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-sulfonylmethyl)phenyl]-3-(4-sulfonylazidophenyl)-2(5H)furanone, Cox Inhibitor 10a; IC50: 31500 nM; Cyclooxygenase-1 (COX-1); 31500.0 nM 4-[4-(N-sulfonylmethyl)phenyl]-3-(4-sulfonylazidophenyl)-2(5H)furanone CHEBI:NONE_148750 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:15050636 PENTACON PENTACON Notes: Request Chebi ID: 4-[4-(N-sulfonylmethyl)phenyl]-3-(4-sulfonylazidophenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002598 Jenn P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 4-[4-(N-sulfonylazido)phenyl]-3-(4-sulfonylmethylphenyl)-2(5H)furanone, Cox Inhibitor 10b; IC50: 3100 nM; Cyclooxygenase-2 (COX-2); 3100.0 nM 4-[4-(N-sulfonylazido)phenyl]-3-(4-sulfonylmethylphenyl)-2(5H)furanone CHEBI:NONE_148751 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:15050636 PENTACON PENTACON Notes: Request Chebi ID: 4-[4-(N-sulfonylazido)phenyl]-3-(4-sulfonylmethylphenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002599 Jenn P23219 5742 PTGS1 Homo sapiens 9606 Comment/biophysicochemical properties/IC50 41[4-(N-sulfonylazido)phenyl]-3-(4-sulfonylmethylphenyl)-2(5H)furanone, Cox Inhibitor 10b; IC50: >500000 nM; Cyclooxygenase-1 (COX-1); nM 4-[4-(N-sulfonylazido)phenyl]-3-(4-sulfonylmethylphenyl)-2(5H)furanone CHEBI:NONE_148751 arachidonic acid CHEBI:15843 Y Y ECO:0000006 Pubmed:15050636 PENTACON PENTACON Notes: Request Chebi ID: 4-[4-(N-sulfonylazido)phenyl]-3-(4-sulfonylmethylphenyl)-2(5H)furanone AAP, DGA, AAP-M, ASD 4/21/2014 3 2200002600 curatus P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 PTGS2 protein half-life 12.0 hour Modeling Data; Protein degradation Y Y ECO:0000006 PubMed:19318593 PENTACON zymosan-induced COX2 expression in human dendritic cells AAP, DGA, AAP-M, ASD 2200002648 curatus P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 PTGS2 protein half-life 7.0 hour Modeling Data; Protein degradation Y Y ECO:0000006 PubMed:17429597 PENTACON between 6 and 8 h; Figure 1A AAP, DGA, AAP-M, ASD 2200002649 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km 5 uM for (s)-tetralol 5.0 uM (s)-tetralol CHEBI:NONE_161457 Y Y ECO:0000006 PubMed:8573067 UniProtKB AAP, ASD 9/3/2014 155 2200002650 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km 38 uM for (s)-indan-1-ol 38.0 uM (s)-indan-1-ol CHEBI:NONE_161458 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 155 2200002651 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km 580 uM for benzene dihydrodiol 580.0 uM benzene CHEBI:16716 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 155 2200002652 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km 3 uM for 5-beta-pregnane-3-alpha,20-alpha-diol 3.0 uM 5-beta-pregnane-3-alpha,20-alpha-diol CHEBI:NONE_161459 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 155 2200002653 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km 3 uM for 5-beta-pregnan-20-alpha-ol-3-one 3.0 uM 5-beta-pregnan-20-alpha-ol-3-one CHEBI:NONE_161460 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 155 2200002654 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km 12 uM for 4-pregnen-20-alpha-ol-3-one 12.0 uM 4-pregnen-20-alpha-ol-3-one CHEBI:NONE_161461 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 155 2200002655 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km 133 uM for 9-alpha,11-beta-PGF2 133.0 uM 9-alpha,11-beta-PGF2 CHEBI:NONE_161462 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 155 2200002656 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km 2 uM for 5-beta-pregnan-3-alpha-ol-20-one 2.0 uM 5-beta-pregnan-3-alpha-ol-20-one CHEBI:NONE_161463 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 155 2200002657 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km 1 uM for 5-beta-androstane-3,17-dione 1.0 uM 5-beta-androstane-3,17-dione CHEBI:NONE_161464 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 155 2200002658 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km 12 uM for PGD2 12.0 uM prostaglandin D2 CHEBI:15555 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 155 2200002659 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km 0.6 uM for 20-alpha-hydroxyprogesterone (with NADH) 0.6 uM 20-alpha-hydroxyprogesterone CHEBI:NONE_161465 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 155 2200002660 curatus Q8N8N7 145482 PTGR2 Homo sapiens 9606 Comment/biophysicochemical properties/Km 11.21 uM for 15-keto-PGE2 11.21 uM 15-dehydro-prostaglandin E2 CHEBI:15547 Y Y ECO:0000269 PubMed:19000823 UniProtKB AAP, ASD 9/3/2014 105 2200002661 curatus Q8N8N7 145482 PTGR2 Homo sapiens 9606 Comment/biophysicochemical properties/Km 15.87 uM for NADPH 15.87 uM NADPH CHEBI:16474 Y Y UniProtKB AAP, ASD 9/3/2014 105 2200002662 curatus Q8N8N7 145482 PTGR2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 159 nmol/min/mg enzyme for 15-keto-PGE2 159.0 nmol/min/mg 15-dehydro-prostaglandin E2 CHEBI:15547 Y Y UniProtKB AAP, ASD 9/3/2014 105 2200002663 curatus Q8N8N7 145482 PTGR2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 67 nmol/min/mg enzyme for NADPH 67.0 nmol/min/mg NADPH CHEBI:16474 Y Y UniProtKB AAP, ASD 9/3/2014 105 2200002664 curatus Q5T3U5 89845 ABCC10 Homo sapiens 9606 Comment/biophysicochemical properties/Km 57.8 uM for 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius) 57.8 uM 17beta-estradiol 17-glucosiduronic acid CHEBI:791 Y Y ECO:0000269 PubMed:12527806 UniProtKB temp: 37 degree Celsius AAP, ASD 9/3/2014 94 2200002665 curatus Q5T3U5 89845 ABCC10 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 20 pmol/min/mg enzyme toward 17-beta-estradiol 17-(beta-D-glucuronide) (at 37 degrees Celsius) 20.0 pmol/min/mg 17beta-estradiol 17-glucosiduronic acid CHEBI:791 Y Y UniProtKB temp: 37 degree Celsius AAP, ASD 9/3/2014 94 2200002666 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Comment/biophysicochemical properties/Km 260 uM for (s)-tetralol 260.0 uM (s)-tetralol CHEBI:NONE_161457 Y Y ECO:0000006 PubMed:8573067 UniProtKB AAP, ASD 9/3/2014 148 2200002667 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Comment/biophysicochemical properties/Km 520 uM for (s)-indan-1-ol 520.0 uM (s)-indan-1-ol CHEBI:NONE_161458 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 148 2200002668 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Comment/biophysicochemical properties/Km 5000 uM for benzene dihydrodiol 5000.0 uM benzene CHEBI:16716 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 148 2200002669 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Comment/biophysicochemical properties/Km 1 uM for 5-beta-pregnane-3-alpha,20-alpha-diol 1.0 uM 5-beta-pregnane-3-alpha,20-alpha-diol CHEBI:NONE_161459 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 148 2200002670 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Comment/biophysicochemical properties/Km 208 uM for 9-alpha,11-beta-PGF2 208.0 uM 9-alpha,11-beta-PGF2 CHEBI:NONE_161462 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 148 2200002671 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Comment/biophysicochemical properties/Km 0.3 uM for 5-beta-androstane-3,17-dione 0.3 uM 5-beta-androstane-3,17-dione CHEBI:NONE_161464 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 148 2200002672 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Comment/biophysicochemical properties/Km 79 uM for PGD2 79.0 uM PGD2 MP:0002515 Y Y ECO:0000311 UniProtKB AAP, ASD 9/3/2014 148 2200002673 curatus Q15067 51 ACOX1 Homo sapiens 9606 Comment/biophysicochemical properties/Km 73 uM for palmitoyl-CoA (isoform 1) 73.0 uM palmitoyl-CoA CHEBI:15525 Y Y ECO:0000269 PubMed:17603022 UniProtKB AAP, ASD 9/3/2014 152 2200002674 curatus Q15067 51 ACOX1 Homo sapiens 9606 Comment/biophysicochemical properties/Km 90 uM for palmitoyl-CoA (isoform 2) 90.0 uM palmitoyl-CoA CHEBI:15525 Y Y UniProtKB changed Isoform dropdown box to isoform 2 AAP, ASD 9/3/2014 152 2200002675 curatus Q9Y4D2 747 DAGLA Homo sapiens 9606 Comment/biophysicochemical properties/Km 154.7 uM for diacylglycerol 154.7 uM 1-stearoyl-2-arachidonoyl-sn-glycerol CHEBI:75728 Y Y ECO:0000269 PubMed:14610053 UniProtKB sn-1-stearoyl-2-[14C]arachidonoyl-glycerol as a substrate AAP, ASD 9/3/2014 103 2200002678 curatus Q8N6M6 84909 AOPEP Homo sapiens 9606 Comment/biophysicochemical properties/Km 6 uM for Arg-AMC 6.0 uM peptide CHEBI:16670 Y Y ECO:0000269 PubMed:15687497 UniProtKB substrate is arginine-7-amino-4-methylcoumarin AAP 7/9/2014 103 2200002680 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km #13# 0.0004 {5alpha-pregnane-3alpha,20alpha-diol} (#13# mutant L308V, pH 7.4, 25°C <47>) <47> 0.04 uM 5alpha-pregnane-3alpha,20alpha-diol CHEBI:NONE_161473 1.1.1.149 #13# mutant L308V, pH 7.4, 25°C <47> Y Y ECO:0000006 Pubmed:20656485 BRENDA KEGG COMPOUND: C18042; <47> Dhagat, U.; Endo, S.; Soda, M.; Hara, A.; El-Kabbani, O.: Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme. Bioorg. Med. Chem. Lett. (2010) 20, 5274-5276. {Pubmed:20656485} AAP, ASD 12/7/2011 1111 2200002688 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km #13# 0.007 {(S)-tetralol} (#13# wild-type, pH 7.4, 25°C <47>) <47> 0.7 uM (s)-tetralol CHEBI:NONE_161457 1.1.1.149 #13# wild-type, pH 7.4, 25°C <47> Y Y ECO:0000006 Pubmed:20656485 BRENDA <47> Dhagat, U.; Endo, S.; Soda, M.; Hara, A.; El-Kabbani, O.: Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme. Bioorg. Med. Chem. Lett. (2010) 20, 5274-5276. {Pubmed:20656485} AAP, ASD 12/7/2011 1111 2200002689 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km #13# 0.47 {(S)-tetralol} (#13# mutant L308A, pH 7.4, 25°C <47>) <47> 47.0 uM (s)-tetralol CHEBI:NONE_161457 1.1.1.149 #13# mutant L308A, pH 7.4, 25°C <47> Y Y ECO:0000006 Pubmed:20656485 BRENDA <47> Dhagat, U.; Endo, S.; Soda, M.; Hara, A.; El-Kabbani, O.: Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme. Bioorg. Med. Chem. Lett. (2010) 20, 5274-5276. {Pubmed:20656485} AAP, ASD 12/7/2011 1111 2200002690 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km #13# 0.0062 {5beta-Pregnan-3alpha-ol-20-one} (#13# mutant L308V, pH 7.4, 25°C <47>) <47> 0.62 uM 5beta-Pregnan-3alpha-ol-20-one CHEBI:NONE_161474 1.1.1.149 #13# mutant L308V, pH 7.4, 25°C <47> Y Y ECO:0000006 Pubmed:20656485 BRENDA <47> Dhagat, U.; Endo, S.; Soda, M.; Hara, A.; El-Kabbani, O.: Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme. Bioorg. Med. Chem. Lett. (2010) 20, 5274-5276. {Pubmed:20656485} AAP, ASD 12/7/2011 1111 2200002691 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km #13# 0.016 {(S)-tetralol} (#13# mutant L308V, pH 7.4, 25°C <47>) <47> 1.6 uM (s)-tetralol CHEBI:NONE_161457 1.1.1.149 #13# mutant L308V, pH 7.4, 25°C <47> Y Y ECO:0000006 Pubmed:20656485 BRENDA Chembl chemical ID: CHEMBL206199; <47> Dhagat, U.; Endo, S.; Soda, M.; Hara, A.; El-Kabbani, O.: Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme. Bioorg. Med. Chem. Lett. (2010) 20, 5274-5276. {Pubmed:20656485} AAP, ASD 12/7/2011 1111 2200002692 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km #3,13# 0.0009 {5alpha-pregnane-3alpha,20alpha-diol} (#3# pH 7.0, 25°C <30>; #13# wild-type, pH 7.4, 25°C <47>) <30,47> 0.09 uM 5alpha-pregnane-3alpha,20alpha-diol CHEBI:NONE_161473 1.1.1.149 #3# pH 7.0, 25°C <30>; #13# wild-type, pH 7.4, 25°C <47> Y Y ECO:0000006 Pubmed:20656485 BRENDA KEGG COMPOUND: C18042; <47> Dhagat, U.; Endo, S.; Soda, M.; Hara, A.; El-Kabbani, O.: Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme. Bioorg. Med. Chem. Lett. (2010) 20, 5274-5276. {Pubmed:20656485} AAP, ASD 12/7/2011 1111 2200002693 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Km #3,13# 0.0045 {5beta-Pregnan-3alpha-ol-20-one} (#3# pH 7.0, 25°C <30>; #13# wild-type, pH 7.4, 25°C <47>) <30,47> 0.45 uM 5beta-Pregnan-3alpha-ol-20-one CHEBI:NONE_161474 1.1.1.149 #3# pH 7.0, 25°C <30>; #13# wild-type, pH 7.4, 25°C <47> Y Y ECO:0000006 Pubmed:20656485 BRENDA <47> Dhagat, U.; Endo, S.; Soda, M.; Hara, A.; El-Kabbani, O.: Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme. Bioorg. Med. Chem. Lett. (2010) 20, 5274-5276. {Pubmed:20656485} AAP, ASD 12/7/2011 1111 2200002694 curatus Q99685 11343 MGLL Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Phenylboronic Acid, 3; IC50: 38000.0 nM; Monoglyceride Lipase (MGL); 38000.0 nM Phenylboronic Acid, 3 CHEBI:NONE_161679 26124 pH: 7.4; temp: 37.00 C Y Y ECO:0000006 PubMed:18983140 BindingDB AAP, ASD 9/1/2014 0 2200002974 curatus Q99685 11343 MGLL Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Phenylboronic Acid, 5; IC50: 71000.0 nM; Monoglyceride Lipase (MGL); 71000.0 nM Phenylboronic Acid, 5 CHEBI:NONE_161680 26126 pH: 7.4; temp: 37.00 C Y Y ECO:0000006 PubMed:18983140 BindingDB AAP, ASD 9/1/2014 0 2200002975 curatus Q99685 11343 MGLL Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Phenylboronic Acid, 8; IC50: 20000.0 nM; Monoglyceride Lipase (MGL); 20000.0 nM Phenylboronic Acid, 8 CHEBI:NONE_161681 26129 pH: 7.4; temp: 37.00 C Y Y ECO:0000006 PubMed:18983140 BindingDB AAP, ASD 9/1/2014 0 2200002976 curatus Q99685 11343 MGLL Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Phenylboronic Acid, 11; IC50: 19000.0 nM; Monoglyceride Lipase (MGL); 19000.0 nM Phenylboronic Acid, 11 CHEBI:NONE_161682 26132 pH: 7.4; temp: 37.00 C Y Y ECO:0000006 PubMed:18983140 BindingDB AAP, ASD 9/1/2014 0 2200002977 curatus Q99685 11343 MGLL Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Phenylboronic Acid, 13; IC50: 7900.0 nM; Monoglyceride Lipase (MGL); 7900.0 nM Phenylboronic Acid, 13 CHEBI:NONE_161683 26134 pH: 7.4; temp: 37.00 C Y Y ECO:0000006 PubMed:18983140 BindingDB AAP, ASD 9/1/2014 0 2200002978 curatus Q99685 11343 MGLL Homo sapiens 9606 Comment/biophysicochemical properties/IC50 1-benzothiophen-2-ylboronic acid, 18; IC50: 32000.0 nM; Monoglyceride Lipase (MGL); 32000.0 nM 1-benzothiophen-2-ylboronic acid, 18 CHEBI:NONE_161684 26139 pH: 7.4; temp: 37.00 C Y Y ECO:0000006 PubMed:18983140 BindingDB AAP, ASD 9/1/2014 0 2200002979 curatus Q99685 11343 MGLL Homo sapiens 9606 Comment/biophysicochemical properties/IC50 1-benzofuran-2-ylboronic acid, 19; IC50: 100000.0 nM; Monoglyceride Lipase (MGL); 100000.0 nM 1-benzofuran-2-ylboronic acid, 19 CHEBI:NONE_161685 26140 pH: 7.4; temp: 37.00 C Y Y ECO:0000006 PubMed:18983140 BindingDB AAP, ASD 9/1/2014 0 2200002980 curatus Q99685 11343 MGLL Homo sapiens 9606 Comment/biophysicochemical properties/IC50 Alkenylboronic Acid, 22; IC50: 31000.0 nM; Monoglyceride Lipase (MGL); 31000.0 nM Alkenylboronic Acid, 22 CHEBI:NONE_161686 26143 pH: 7.4; temp: 37.00 C Y Y ECO:0000006 PubMed:18983140 BindingDB AAP, ASD 9/1/2014 0 2200002981 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Comment/biophysicochemical properties/Ki 3,5-dichlorosalicylic acid; Ki: 5.9 nM; 20-alpha-Hydroxysteroid Dehydrogenase (AKR1C1); 5.9 nM 3,5-dichloro-4-hydroxybenzoic acid CHEBI:53685 26269 pH: 7.4; temp: 25.00 C Y Y ECO:0000006 PubMed:18620380 BindingDB AAP, ASD 9/1/2014 0 2200002982 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Comment/biophysicochemical properties/Ki 3,5-dichlorosalicylic acid; Ki: 70.0 nM; 3-alpha-Hydroxysteroid Dehydrogenase Type 3 (AKR1C2); 70.0 nM 3,5-dichloro-4-hydroxybenzoic acid CHEBI:53685 26269 pH: 7.4; temp: 25.00 C Y Y ECO:0000006 PubMed:18620380 BindingDB AAP, ASD 9/1/2014 0 2200002983 curatus P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 PTGS2 protein half-life 5.0 hour Modeling Data; Protein degradation Y Y ECO:0000006 PubMed:18203712 PENTACON Tetracycline-inducible promoter used to drive expression of human COX-2; not induced by growth or cytokine factors; transfected HEK293 cells AAP, DGA, AAP-M, ASD 2200003094 curatus P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 PTGS2 protein half-life 2.5 hour Modeling Data; Protein degradation Y Y ECO:0000006 PubMed:18203712 PENTACON Figure 5A; in mouse NIH/3T3 fibroblasts using Tet-inducible promoter to drive COX-2 expression AAP, DGA, AAP-M, ASD 2200003095 curatus P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 PTGS2 protein half-life 4.0 hour arachidonic acid CHEBI:15843 Modeling Data; Protein degradation Y Y ECO:0000006 PubMed:18203712 PENTACON Figure 8B, lane 8; in mouse NIH3T3 fibroblasts, to induce COX-2 expression serum and 20microMolar arachidonic acid was added to cultures. AAP, DGA, AAP-M, ASD 2200003096 curatus P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 PTGS2 protein half-life 7.0 hour Modeling Data; Protein degradation Y Y ECO:0000006 PubMed:17429597 PENTACON Figure 1A; half life of 6-8 hours for recombinant COX-2 in HeLA cells AAP, DGA, AAP-M, ASD 2200003097 curatus P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 PTGS2 protein half-life 2.0 hour parecoxib CHEBI:73038 Modeling Data; Protein degradation Y Y ECO:0000006 PubMed:17429597 PENTACON Figure 1A; half life of ~<2 hours for recombinant COX-2 in HeLA cells treated with 10 microMolar Parecoxib (half of which was converted to Valdecoxib in culture) AAP, DGA, AAP-M, ASD 2200003098 curatus P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 PTGS2 protein half-life 1.5 hour parecoxib CHEBI:73038 curcumin CHEBI:3962 Modeling Data; Protein degradation Y Y ECO:0000006 PubMed:17429597 PENTACON Figure 1A; half life of ~1 hours for recombinant COX-2 in HeLA cells treated with 10 microMolar Parecoxib (half of which was converted to Valdecoxib in culture) and curcumin AAP, DGA, AAP-M, ASD 2200003099 curatus P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 PTGS2 protein half-life 4.0 hour Modeling Data; Protein degradation Y Y ECO:0000006 PubMed:10930401 PENTACON Figure 7B; ~4 h steady-state stability in colon carcinoma HCA-7 cell line (no induction treatment) AAP, DGA, AAP-M, ASD 2200003100 curatus P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 PTGS2 protein half-life 3.5 hour Modeling Data; Protein degradation Y Y ECO:0000006 PubMed:10930401 PENTACON Figure 7B; ~3.5 h steady-state stability in colon carcinoma Moser cell line (no induction treatment) AAP, DGA, AAP-M, ASD 2200003101 curatus P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 PTGS2 protein half-life 8.0 hour Modeling Data; Protein degradation Y Y ECO:0000006 PubMed:10930401 PENTACON Figure 7B; ~8 h steady-state stability in colon carcinoma LS-174 cell line (no induction treatment) AAP, DGA, AAP-M, ASD 2200003102 curatus P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 PTGS2 protein half-life 4.0 hour Modeling Data; Protein degradation Y Y ECO:0000006 PubMed:10930401 PENTACON Figure 7B; ~4 h steady-state stability in colon carcinoma HT-29 cell line (no induction treatment) AAP, DGA, AAP-M, ASD 2200003103 curatus P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 PTGS2 protein half-life 2.0 hour Modeling Data; Protein degradation Y Y ECO:0000006 PubMed:10766854 PENTACON Fig 6A; THP-1 monocytes, LPS-treated cells AAP, DGA, AAP-M, ASD 2200003104 curatus O60488 2182 ACSL4 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 ACSL4 protein half-life 17.0 hour Modeling Data; Protein Degradation Y Y ECO:0000006 PubMed:24879802 PENTACON 17.3 ± 1.8 h ACSL protein half-life in HepG2 cells AAP, AAP-M, ASD 2200003119 curatus O60488 2182 ACSL4 Homo sapiens 9606 Comment/biophysicochemical properties/t1/2 ACSL4 protein half-life 4.2 hour arachidonic acid CHEBI:15843 Modeling Data; Protein Degradation Y Y ECO:0000006 PubMed:24879802 PENTACON 4.2 ± 0.4 h ACSL protein half-life in HepG2 cells treated with arachidonic acid AAP, AAP-M, ASD 2200003120 curatus P33527 4363 ABCC1 Homo sapiens 9606 Comment/biophysicochemical properties/Velocity Secretion of LTC4 150.0 pmol/min/mg leukotriene C4 CHEBI:16978 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:8621643 PENTACON Figure 1A; inside-out membrane vesicles prepared from HeLa cells transfected with ABCC1; ATP-dependent transport AAP, DGA, AAP-M, ASD 2200003143 curatus P33527 4363 ABCC1 Homo sapiens 9606 Comment/biophysicochemical properties/Velocity Secretion of LTC4 300.0 pmol/min/mg leukotriene C4 CHEBI:16978 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:8621643 PENTACON Figure 1B (estimate); inside-out membrane vesicles prepared from H69AR lung cancer cells (high ABCC1 expression); ATP-dependent transport AAP, DGA, AAP-M, ASD 2200003146 curatus Q96J66 85320 ABCC11 Homo sapiens 9606 Comment/biophysicochemical properties/Velocity Secretion of LTC4 0.42 pmol/min/mg leukotriene C4 CHEBI:16978 ATP CHEBI:15422 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:15537867 PENTACON Figure 4A; membrane vesicles prepared from LLC-PK1 cells transfected with ABCC11 AAP, DGA, AAP-M 2200003147 curatus P33527 4363 ABCC1 Homo sapiens 9606 Comment/biophysicochemical properties/Velocity Secretion of LTC4 55.0 pmol/min/mg leukotriene C4 CHEBI:16978 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:7961706 PENTACON Table 1; membrane vesicles prepared from HeLa cells transfected with ABCC1; ATP-dependent transport AAP, DGA, AAP-M, ASD 2200003164 curatus P33527 4363 ABCC1 Homo sapiens 9606 Comment/biophysicochemical properties/Velocity Secretion of LTD4 15.0 pmol/min/mg leukotriene D4 CHEBI:28666 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:7961706 PENTACON Table 1; membrane vesicles prepared from HeLa cells transfected with ABCC1; ATP-dependent transport; considered background level AAP, DGA, AAP-M, ASD 2200003165 curatus P33527 4363 ABCC1 Homo sapiens 9606 Comment/biophysicochemical properties/Velocity Secretion of LTE4 8.0 pmol/min/mg leukotriene E4 CHEBI:15650 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:7961706 PENTACON Table 1; membrane vesicles prepared from HeLa cells transfected with ABCC1; ATP-dependent transport; considered background level AAP, DGA, AAP-M, ASD 2200003166 curatus O15439 10257 ABCC4 Homo sapiens 9606 Comment/biophysicochemical properties/Velocity Secretion of PGE1 0.0275 pmol/min/mg prostaglandin E1 CHEBI:15544 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:15537867 PENTACON estimated from Figure 6A; membrane vesicles prepared from HEK293 cells transfected with ABCC4; ATP-dependent transport AAP, AAP-M, ASD 2200003169 curatus O15439 10257 ABCC4 Homo sapiens 9606 Comment/biophysicochemical properties/Velocity Secretion of PGE2 0.0018 pmol/min/mg prostaglandin E2 CHEBI:15551 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:15537867 PENTACON estimated from Figure 6B; membrane vesicles prepared from HEK293 cells transfected with ABCC4; ATP-dependent transport AAP, AAP-M, ASD 2200003170 curatus Q92887 1244 ABCC2 Homo sapiens 9606 Comment/biophysicochemical properties/Velocity Secretion of LTC4 48.0 pmol/min/mg leukotriene C4 CHEBI:16978 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:10220572 PENTACON Figure 4; inside-out membrane vesicles prepared from HEK-293 cells transfected with ABCC2; ATP-dependent transport AAP, AAP-M, ASD 2200003171 curatus P33527 4363 ABCC1 Homo sapiens 9606 Comment/biophysicochemical properties/Velocity Secretion of LTC4 25.0 pmol/min/mg leukotriene C4 CHEBI:16978 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:7915193 PENTACON Figure 1A; inside-out membrane vesicles prepared from HL60/ADR cells (ABCC1 overexpression); ATP-dependent transport AAP, DGA, AAP-M, ASD 2200003173 curatus Q16647 5740 PTGIS Homo sapiens 9606 Comment/biophysicochemical properties/Km PGH2 converted to PGI2 by PTGIS 13.3 uM prostaglandin H2 CHEBI:15554 prostaglandin I2 CHEBI:15552 Modeling Data; Michaelis Y Y ECO:0000006 PubMed:16406803 PENTACON PTGIS is modified by replacing the hydrophobic amino-terminal sequence with the more hydrophilic amino-terminal sequence from P450 2C5 and by adding a four-histidine tag at the carboxyl terminus to facilitate purification. AAP, DGA, AAP-M, ASD 2200003174 curatus Q16647 5740 PTGIS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax PGH2 converted to PGI2 by PTGIS 980.0 mol/min/mol prostaglandin H2 CHEBI:15554 prostaglandin I2 CHEBI:15552 Modeling Data; Michaelis Y Y ECO:0000006 PubMed:16406803 PENTACON PTGIS is modified by replacing the hydrophobic amino-terminal sequence with the more hydrophilic amino-terminal sequence from P450 2C5 and by adding a four-histidine tag at the carboxyl terminus to facilitate purification. AAP, DGA, AAP-M, ASD 2200003175 curatus P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/Km AA converted to 12(S)HPETE by ALOX12 3.0 uM arachidonic acid CHEBI:15843 12(S)-HETE CHEBI:34146 Modeling Data; Michaelis Y Y ECO:0000006 PubMed:18155727 PENTACON AAP, DGA, AAP-M 2200003178 curatus P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax AA converted to 12(S)HPETE by ALOX12 0.35 umol/min/mg arachidonic acid CHEBI:15843 12(S)-HETE CHEBI:34146 Modeling Data; Michaelis Y Y ECO:0000006 PubMed:18155727 PENTACON #Copied from ALOX12, anno: 3178 AAP, DGA, AAP-M 2200003179 curatus P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/Km AA converted to 12(S)HPETE by ALOX12 7.2 uM arachidonic acid CHEBI:15843 12(S)-HETE CHEBI:34146 Modeling Data; Michaelis Y Y ECO:0000033 PubMed:18155727 PENTACON cytosol from sonicated platelets; #Copied from ALOX12, anno: 3178 AAP, DGA, AAP-M 2200003180 curatus P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax AA converted to 12(S)HPETE by ALOX12 4.9 nmol/min/mg arachidonic acid CHEBI:15843 12(S)-HETE CHEBI:34146 Modeling Data; Michaelis Y Y ECO:0000033 PubMed:18155727 PENTACON membrane associated enzyme; Copied from ALOX12, anno: 3179 AAP, DGA, AAP-M 2200003181 curatus P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/Km AA converted to 12(S)HPETE by ALOX12 18.0 uM arachidonic acid CHEBI:15843 12(S)-HETE CHEBI:34146 Modeling Data; Michaelis Y Y ECO:0000033 PubMed:18155727 PENTACON enzyme solubilized from intact human platelets; #Copied from ALOX12, anno: 3178 AAP, DGA, AAP-M 2200003182 curatus P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/Km AA converted to 12(S)HPETE by ALOX12 8.7 uM arachidonic acid CHEBI:15843 12(S)-HETE CHEBI:34146 Modeling Data; Michaelis Y Y ECO:0000033 PubMed:18155727 PENTACON membrane-associated enzyme from sonicated platelets; #Copied from ALOX12, anno: 3178 #Copied from ALOX12, anno: 3180 AAP, DGA, AAP-M 2200003183 curatus P18054 239 ALOX12 Homo sapiens 9606 Comment/biophysicochemical properties/Km AA converted to 12(S)HPETE by ALOX12 4.0 uM arachidonic acid CHEBI:15843 12(S)-HETE CHEBI:34146 Modeling Data; Michaelis Y Y ECO:0000033 PubMed:18155727 PENTACON human platelet cytosol LOX activity measured by oxygen consumption; #Copied from ALOX12, anno: 3178 #Copied from ALOX12, anno: 3182 AAP, DGA, AAP-M 2200003184 curatus Q96J66 85320 ABCC11 Homo sapiens 9606 Comment/biophysicochemical properties/Velocity Secretion of LTC4 0.24 pmol/min/mg leukotriene C4 CHEBI:16978 AMP CHEBI:16027 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:15537867 PENTACON Figure 4A; membrane vesicles prepared from LLC-PK1 cells transfected with ABCC11 AAP, DGA, AAP-M 2200003185 curatus Q92887 1244 ABCC2 Homo sapiens 9606 Comment/biophysicochemical properties/Km Secretion of LTC4 1.0 uM leukotriene C4 CHEBI:16978 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:10220572 PENTACON Table 1; inside-out membrane vesicles prepared from HEK-293 cells transfected with ABCC2; ATP-dependent transport AAP, AAP-M, ASD 2200003186 curatus P33527 4363 ABCC1 Homo sapiens 9606 Comment/biophysicochemical properties/Km Secretion of LTC4 97.0 nM leukotriene C4 CHEBI:16978 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:7961706 PENTACON Figure 2; membrane vesicles prepared from HeLa cells transfected with ABCC1; ATP-dependent transport AAP, DGA, AAP-M, ASD 2200003190 curatus P33527 4363 ABCC1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax Secretion of LTC4 100.0 pmol/min/mg leukotriene C4 CHEBI:16978 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:7961706 PENTACON Figure 2; membrane vesicles prepared from HeLa cells transfected with ABCC1; ATP-dependent transport AAP, DGA, AAP-M, ASD 2200003191 curatus P33527 4363 ABCC1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax Secretion of LTC4 529.0 pmol/min/mg leukotriene C4 CHEBI:16978 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:8621643 PENTACON Figure 3A; inside-out membrane vesicles prepared from HeLa cells transfected with ABCC1 AAP, DGA, AAP-M, ASD 2200003192 curatus P33527 4363 ABCC1 Homo sapiens 9606 Comment/biophysicochemical properties/Km Secretion of LTC4 105.0 nM leukotriene C4 CHEBI:16978 Modeling Data; Membrane transport Y Y ECO:0000006 PubMed:8621643 PENTACON Figure 3A; inside-out membrane vesicles prepared from HeLa cells transfected with ABCC1 AAP, DGA, AAP-M, ASD 2200003193 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant V69T; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003255 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.002 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant V69T; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003256 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant V69T; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003257 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 1.9e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant V69T; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003258 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 6.4e-06 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant R51H; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003259 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant R51H; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003260 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0038 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant R51H; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003261 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant R51H; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003262 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant Y93F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003263 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant Y93F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003264 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant C82V; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003265 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.002 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant C82V; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003266 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 1.09e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant C82V; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003267 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant C82V; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003268 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 4.5e-06 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant A52S; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003269 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant A52S; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003270 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant A52S; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003271 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.03 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant A52S; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003272 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant Y59F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003273 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0155 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant Y59F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003274 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant Y59F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003275 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 1.9e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant Y59F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003276 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant Y109I; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003277 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant Y109I; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003278 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0016 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant Y109I; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003279 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0165 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant Y97F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003280 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 1.65e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant Y97F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003281 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant Y97F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003282 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant Y97F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003283 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant N55A; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003284 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0107 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant N55A; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003285 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant N55A; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003286 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 7.7e-06 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant N55A; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003287 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0092 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant V49F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003288 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 1e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant V49F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003289 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant V49F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003290 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant V49F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003291 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 9.4e-06 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant R51K; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003292 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant R51K; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003293 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant R51K; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003294 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0023 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant R51K; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003295 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 6.7e-06 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant L62T; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003296 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant L62T; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003297 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0025 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant L62T; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003298 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant L62T; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003299 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant R511/wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003300 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0032 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant R511/wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003301 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 6.5e-06 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant R511/wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003302 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant R511/wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003303 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.02 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant R51H; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003304 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 6.3e-06 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant R51H; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003305 curatus Q16873 4056 LTC4S Homo sapiens 9606 Vmax Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.000333 mol*s^(-1)*g^(-1) 4.4.1.20;8569 mutant R51H; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003306 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0015 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant R51H; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003307 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 5.4e-06 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant Y93F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003308 curatus Q16873 4056 LTC4S Homo sapiens 9606 Vmax Leukotriene A4 + Reduced glutathione = Leukotriene C4 2.33e-05 mol*s^(-1)*g^(-1) 4.4.1.20;8569 mutant Y93F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003309 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.02 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant Y93F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003310 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.099 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant Y93F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003311 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0009 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 mutant C82V; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003312 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.02 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant C82V; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003313 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 6.3e-06 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 mutant C82V; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003314 curatus Q16873 4056 LTC4S Homo sapiens 9606 Vmax Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.000628 mol*s^(-1)*g^(-1) 4.4.1.20;8569 mutant C82V; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant AAP, DGA, ASD 0 220003315 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK AAP, DGA, ASD 0 220003316 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK AAP, DGA, ASD 0 220003317 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0014 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK AAP, DGA, ASD 0 220003318 curatus Q16873 4056 LTC4S Homo sapiens 9606 Vmax Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.000855 mol*s^(-1)*g^(-1) 4.4.1.20;8569 wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK AAP, DGA, ASD 0 220003319 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 7.4e-06 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK AAP, DGA, ASD 0 220003320 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Km O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 1.71e-06 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 mutant D269A; 37.0; 7.5|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:unknown Y Y PubMed:8486631 SabioRK Mutant AAP 0 220003321 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 kcat O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.0266666667 mol*s^(-1)*mol^(-1) 1.14.13.30;3615 mutant D269A; 37.0; 7.5|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:unknown Y Y PubMed:8486631 SabioRK Mutant AAP 0 220003322 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.001 M NADPH CHEBI:16474 1.14.13.30;3615 mutant D269A; 37.0; 7.5|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:unknown Y Y PubMed:8486631 SabioRK Mutant AAP 0 220003323 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Km 20-CHO-Leukotriene B4 + O2 + H+ + NADPH = 20-COOH-Leukotriene B4 + H2O + NADP+ 8e-08 M 20-CHO-Leukotriene B4 CHEBI:NONE_161822 1.14.13.30;9867 wildtype isoenzyme CYP4F3; 37.0; 8.0|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:microsome Y Y PubMed:2549038 SabioRK AAP 0 220003324 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration 20-CHO-Leukotriene B4 + O2 + H+ + NADPH = 20-COOH-Leukotriene B4 + H2O + NADP+ 0.0001 M NADPH CHEBI:16474 1.14.13.30;9867 wildtype isoenzyme CYP4F3; 37.0; 8.0|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:microsome Y Y PubMed:2549038 SabioRK AAP 0 220003325 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Vmax 20-CHO-Leukotriene B4 + O2 + H+ + NADPH = 20-COOH-Leukotriene B4 + H2O + NADP+ 5.67e-11 mol*s^(-1)*g^(-1) 1.14.13.30;9867 wildtype isoenzyme CYP4F3; 37.0; 8.0|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:microsome Y Y PubMed:2549038 SabioRK AAP 0 220003326 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Km 20-CHO-Leukotriene B4 + O2 + H+ + NADPH = 20-COOH-Leukotriene B4 + H2O + NADP+ 1.2e-07 M 20-CHO-Leukotriene B4 CHEBI:NONE_161822 1.14.13.30;9867 wildtype isoenzyme CYP4F3; 37.0; 8.0|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:microsome Y Y PubMed:2549038 SabioRK AAP 0 220003327 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Vmax 20-CHO-Leukotriene B4 + O2 + H+ + NADPH = 20-COOH-Leukotriene B4 + H2O + NADP+ 8.33e-11 mol*s^(-1)*g^(-1) 1.14.13.30;9867 wildtype isoenzyme CYP4F3; 37.0; 8.0|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:microsome Y Y PubMed:2549038 SabioRK AAP 0 220003328 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Km O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 2.2e-07 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:8.0E-8|Tissue:polymorphonuclear leukocyte|Cellular Location:cytoplasm Y Y PubMed:2986111 SabioRK AAP 0 220003329 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Vmax O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 8e-10 mol*s^(-1)*g^(-1) 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:1.83333E-10|Tissue:polymorphonuclear leukocyte|Cellular Location:cytoplasm Y Y PubMed:2986111 SabioRK AAP 0 220003330 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Km O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 1.01e-06 M NADPH CHEBI:16474 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:5.9E-7|Tissue:polymorphonuclear leukocyte|Cellular Location:cytoplasm Y Y PubMed:2986111 SabioRK AAP 0 220003331 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.0001 M NADPH CHEBI:16474 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:|Tissue:polymorphonuclear leukocyte|Cellular Location:cytoplasm Y Y PubMed:2986111 SabioRK AAP 0 220003332 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Vmax O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 9.12e-10 mol*s^(-1)*g^(-1) 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:|Tissue:polymorphonuclear leukocyte|Cellular Location:cytoplasm Y Y PubMed:2986111 SabioRK AAP 0 220003333 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 1e-06 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype; 37.0; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK AAP 0 220003334 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.05 mg/ml Enzyme CHEBI:NONE_161823 1.14.13.30;3615 wildtype; 37.0; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK AAP 0 220003335 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Km O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 8e-07 M NADPH CHEBI:16474 1.14.13.30;3615 wildtype; 37.0; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK AAP 0 220003336 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.001 M NADPH CHEBI:16474 1.14.13.30;3615 wildtype; 37.0; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK AAP 0 220003337 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Km O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 3e-07 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype; 37.0; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK AAP 0 220003338 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Vmax O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 7e-09 mol*s^(-1)*g^(-1) 1.14.13.30;3615 wildtype; 37.0; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK AAP 0 220003339 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.001 M NADPH CHEBI:16474 1.14.13.30;3615 wildtype; -; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK AAP 0 220003340 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 7.0 mg/ml Enzyme CHEBI:NONE_161823 1.14.13.30;3615 wildtype; -; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK AAP 0 220003341 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Kd O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 4e-07 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype; -; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK AAP 0 220003342 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.001 M NADPH CHEBI:16474 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:unknown Y Y PubMed:8486631 SabioRK AAP 0 220003343 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Km O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 7.1e-07 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:unknown Y Y PubMed:8486631 SabioRK AAP 0 220003344 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Km O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 4e-06 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype isoenzyme CYP4F3A; 37.0; 8.0|std.dev:8.0E-7|Tissue:neutrophil|Cellular Location:unknown Y Y PubMed:10409674 SabioRK AAP 0 220003345 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Vmax O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 9.83e-08 mol*s^(-1)*g^(-1) 1.14.13.30;3615 wildtype isoenzyme CYP4F3A; 37.0; 8.0|std.dev:-|Tissue:neutrophil|Cellular Location:unknown Y Y PubMed:10409674 SabioRK AAP 0 220003346 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.2 mg/ml Enzyme CHEBI:NONE_161823 1.14.13.30;3615 wildtype isoenzyme CYP4F3A; 37.0; 8.0|std.dev:-|Tissue:neutrophil|Cellular Location:unknown Y Y PubMed:10409674 SabioRK AAP 0 220003347 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.0001 M NADPH CHEBI:16474 1.14.13.30;3615 wildtype isoenzyme CYP4F3A; 37.0; 8.0|std.dev:-|Tissue:neutrophil|Cellular Location:unknown Y Y PubMed:10409674 SabioRK AAP 0 220003348 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.0001 M NADPH CHEBI:16474 1.14.13.30;3615 wildtype isoenzyme CYP4F3B; 37.0; 8.0|std.dev:-|Tissue:fetal liver|Cellular Location:microsome Y Y PubMed:10409674 SabioRK AAP 0 220003349 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.2 mg/ml Enzyme CHEBI:NONE_161823 1.14.13.30;3615 wildtype isoenzyme CYP4F3B; 37.0; 8.0|std.dev:-|Tissue:fetal liver|Cellular Location:microsome Y Y PubMed:10409674 SabioRK AAP 0 220003350 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Km O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.000105 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype isoenzyme CYP4F3B; 37.0; 8.0|std.dev:1.3E-5|Tissue:fetal liver|Cellular Location:microsome Y Y PubMed:10409674 SabioRK AAP 0 220003351 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 Vmax O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 1.2e-07 mol*s^(-1)*g^(-1) 1.14.13.30;3615 wildtype isoenzyme CYP4F3B; 37.0; 8.0|std.dev:-|Tissue:fetal liver|Cellular Location:microsome Y Y PubMed:10409674 SabioRK AAP 0 220003352 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.0023 M NADPH CHEBI:16474 1.1.1;7911 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003353 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 kcat/Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 133.333333 M^(-1)*s^(-1) 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1;7911 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003354 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 8.06e-05 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1;7911 wildtype AKR1C1; 25.0; 7.0|std.dev:2.88E-5|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003355 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 kcat H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.011 s^(-1) 1.1.1;7911 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003356 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Vmax H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 3e-07 mol*s^(-1)*g^(-1) 1.1.1;7911 wildtype AKR1C1; 25.0; 7.0|std.dev:8.0E-8|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003357 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.05 mg/ml Enzyme CHEBI:NONE_161823 1.1.1;7911 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003358 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 4.17e-05 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1;2409 wildtype AKR1C1; 25.0; 7.0|std.dev:3.7E-6|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003359 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Vmax NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 2.65e-08 mol*s^(-1)*g^(-1) 1.1.1;2409 wildtype AKR1C1; 25.0; 7.0|std.dev:1.16667E-9|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003360 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.002 M NADP+ CHEBI:NONE_161814 1.1.1;2409 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003361 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 kcat/Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 23.3333333 M^(-1)*s^(-1) 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1;2409 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003362 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 kcat NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.001 s^(-1) 1.1.1;2409 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003363 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.0023 M NADP+ CHEBI:NONE_161814 1.1.1;1917 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003364 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Vmax NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 2e-08 mol*s^(-1)*g^(-1) 1.1.1;1917 wildtype AKR1C1; 25.0; 7.0|std.dev:1.83333E-9|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003365 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.05 mg/ml Enzyme CHEBI:NONE_161823 1.1.1;1917 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003366 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Km NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 3.98e-05 M testosterone CHEBI:17347 1.1.1;1917 wildtype AKR1C1; 25.0; 7.0|std.dev:6.6E-6|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003367 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 kcat/Km NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 18.3333333 M^(-1)*s^(-1) testosterone CHEBI:17347 1.1.1;1917 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003368 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 kcat NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.000733 s^(-1) 1.1.1;1917 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003369 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Km NADP+ + Indan-1-ol = NADPH + Indanone + H+ 4.8e-05 M indan-1-ol CHEBI:16697 1.1.1.112;3366 wildtype isoform AKR1C1; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003370 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 kcat NADP+ + Indan-1-ol = NADPH + Indanone + H+ 0.208333333 s^(-1) 1.1.1.112;3366 wildtype isoform AKR1C1; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003371 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 kcat/Km NADP+ + Indan-1-ol = NADPH + Indanone + H+ 4333.33333 M^(-1)*s^(-1) indan-1-ol CHEBI:16697 1.1.1.112;3366 wildtype isoform AKR1C1; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003372 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration NADP+ + Indan-1-ol = NADPH + Indanone + H+ 0.0023 M NADP+ CHEBI:NONE_161814 1.1.1.112;3366 wildtype isoform AKR1C1; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003373 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 kcat NADPH + H+ + 5alpha-Androstan-17beta-ol-3-one = 5alpha-Androstan-3beta,17beta-diol + NADP+ 0.0123333333 s^(-1) 1.1.1;8080 wildtype AKR1C1; -; 7.0|std.dev:5.0E-4|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK AAP, ASD 0 220003374 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 Km NADPH + H+ + 5alpha-Androstan-17beta-ol-3-one = 5alpha-Androstan-3beta,17beta-diol + NADP+ 4.2e-06 M 5alpha-Dihydrotestosterone CHEBI:NONE_161826 1.1.1;8080 wildtype AKR1C1; -; 7.0|std.dev:5.0E-7|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK AAP, ASD 0 220003375 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 kcat/Km NADPH + H+ + 5alpha-Androstan-17beta-ol-3-one = 5alpha-Androstan-3beta,17beta-diol + NADP+ 3000.0 M^(-1)*s^(-1) 5alpha-Dihydrotestosterone CHEBI:NONE_161826 1.1.1;8080 wildtype AKR1C1; -; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK AAP, ASD 0 220003376 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration NADPH + H+ + 5alpha-Androstan-17beta-ol-3-one = 5alpha-Androstan-3beta,17beta-diol + NADP+ 0.0029 mg/ml Enzyme CHEBI:NONE_161823 1.1.1;8080 wildtype AKR1C1; -; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK AAP, ASD 0 220003377 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 5e-07 M Androstenedione CHEBI:NONE_161827 1.1.1;1917 mutant Y24A; 37.0; 7.3|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:17442338 SabioRK Mutant AAP, ASD 0 220003380 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.001 M NADPH CHEBI:16474 1.1.1;1917 mutant Y24A; 37.0; 7.3|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:17442338 SabioRK Mutant AAP, ASD 0 220003381 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.0215 s^(-1) 1.1.1;1917 mutant Y24A; 37.0; 7.3|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:17442338 SabioRK Mutant AAP, ASD 0 220003382 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat/Km NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 733.333333 M^(-1)*s^(-1) Androstenedione CHEBI:NONE_161827 1.1.1;1917 mutant Y24A; 37.0; 7.3|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:17442338 SabioRK Mutant AAP, ASD 0 220003383 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 2.96e-05 M Androstenedione CHEBI:NONE_161827 1.1.1;1917 mutant Y24A; 37.0; 7.3|std.dev:1.003E-5|Tissue:-|Cellular Location:unknown Y Y PubMed:17442338 SabioRK Mutant AAP, ASD 0 220003384 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 7.8e-06 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1.213;2409 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003385 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.00025 M NADP+ CHEBI:NONE_161814 1.1.1.213;2409 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003386 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.0118333333 s^(-1) 1.1.1.213;2409 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003387 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.000667 s^(-1) 1.1.1.213;7911 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003388 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.00025 M NADP+ CHEBI:NONE_161814 1.1.1.213;7911 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003389 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 5e-06 M 5alpha-androstane-3alpha,17beta-diol CHEBI:36713 1.1.1.213;7911 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003390 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration 5beta-Androstane-17beta-ol-3-one + H+ + NADPH = 5beta-Androstane-3alpha,17beta-diol + NADP+ 5e-06 M 5beta-androstane-3alpha,17beta-diol CHEBI:36714 1.1.1.213;7912 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003391 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat 5beta-Androstane-17beta-ol-3-one + H+ + NADPH = 5beta-Androstane-3alpha,17beta-diol + NADP+ 0.0015 s^(-1) 1.1.1.213;7912 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003392 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration 5beta-Androstane-17beta-ol-3-one + H+ + NADPH = 5beta-Androstane-3alpha,17beta-diol + NADP+ 0.00025 M NADP+ CHEBI:NONE_161814 1.1.1.213;7912 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003393 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 3alpha-Hydroxy-5beta-androstan-17-one = NADPH + H+ + 5beta-Androstane-3,17-dione 0.00025 M NADP+ CHEBI:NONE_161814 1.1.1.213;4009 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003394 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + 3alpha-Hydroxy-5beta-androstan-17-one = NADPH + H+ + 5beta-Androstane-3,17-dione 0.0015 s^(-1) 1.1.1.213;4009 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003395 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 3alpha-Hydroxy-5beta-androstan-17-one = NADPH + H+ + 5beta-Androstane-3,17-dione 5e-06 M 3alpha-hydroxy-5beta-androstan-17-one CHEBI:28195 1.1.1.213;4009 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003396 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.00052 M (s)-indan-1-ol CHEBI:NONE_161458 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003397 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.00025 M NADP+ CHEBI:NONE_161814 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003398 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.266666667 s^(-1) 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003399 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration (R)-Indan-1-ol + NADP+ = H+ + NADPH + Indanone 0.0005 M (R)-Indan-1-ol CHEBI:NONE_161828 1.1.1.213;7881 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003400 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration (R)-Indan-1-ol + NADP+ = H+ + NADPH + Indanone 0.00025 M NADP+ CHEBI:NONE_161814 1.1.1.213;7881 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003401 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat (R)-Indan-1-ol + NADP+ = H+ + NADPH + Indanone 0.005 s^(-1) 1.1.1.213;7881 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003402 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADPH + H+ + 2-Nitrobenzaldehyde = NADP+ + 2-Nitrobenzyl alcohol 6e-07 M 2-nitrobenzaldehyde CHEBI:66927 1.1.1.213;8071 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003403 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADPH + H+ + 2-Nitrobenzaldehyde = NADP+ + 2-Nitrobenzyl alcohol 0.0001 M NADPH CHEBI:16474 1.1.1.213;8071 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003404 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADPH + H+ + 2-Nitrobenzaldehyde = NADP+ + 2-Nitrobenzyl alcohol 0.0533333333 s^(-1) 1.1.1.213;8071 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003405 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + Dimethylglyoxal + NADPH = NADP+ + Acetoin 0.0001 M NADPH CHEBI:16474 1.1.1.213;7997 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003406 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat H+ + Dimethylglyoxal + NADPH = NADP+ + Acetoin 0.035 s^(-1) 1.1.1.213;7997 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003407 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km H+ + Dimethylglyoxal + NADPH = NADP+ + Acetoin 3.3e-06 M Dimethylglyoxal CHEBI:NONE_161829 1.1.1.213;7997 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003408 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 0.0316666667 s^(-1) 1.1.1.213;6776 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003409 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 5.7e-05 M Pyridine-3-aldehyde CHEBI:NONE_161830 1.1.1.213;6776 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003410 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 0.0001 M NADPH CHEBI:16474 1.1.1.213;6776 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003411 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 1.3e-05 M menadione CHEBI:28869 1.1.1.213;9874 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003412 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADPH + Menadione + H+ = Menadiol + NADP+ 0.025 s^(-1) 1.1.1.213;9874 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003413 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.0001 M NADPH CHEBI:16474 1.1.1.213;9874 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003414 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 0.0155 s^(-1) 1.1.1.213;6755 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003415 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 0.0001 M NADPH CHEBI:16474 1.1.1.213;6755 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003416 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 2e-06 M m-Nitrobenzaldehyde CHEBI:NONE_161831 1.1.1.213;6755 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003417 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADPH + H+ + 4-Benzoylpyridine = Unknown + NADP+ 0.011 s^(-1) 1.1.1.213;8093 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003418 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADPH + H+ + 4-Benzoylpyridine = Unknown + NADP+ 0.0001 M NADPH CHEBI:16474 1.1.1.213;8093 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003419 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADPH + H+ + 4-Benzoylpyridine = Unknown + NADP+ 0.0005 M 4-benzoylpyridine CHEBI:NONE_148506 1.1.1.213;8093 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003420 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + Indan-1-ol = NADPH + Indanone + H+ 0.00366666667 s^(-1) 1.1.1.213;3366 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003421 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + Indan-1-ol = NADPH + Indanone + H+ 0.0001 M NADPH CHEBI:16474 1.1.1.213;3366 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003422 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + Indan-1-ol = NADPH + Indanone + H+ 0.0005 M indanone CHEBI:38132 1.1.1.213;3366 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003423 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + 3alpha-Hydroxy-5beta-androstan-17-one = NADPH + H+ + 5beta-Androstane-3,17-dione 0.0103333333 s^(-1) 1.1.1.213;4009 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003424 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 3alpha-Hydroxy-5beta-androstan-17-one = NADPH + H+ + 5beta-Androstane-3,17-dione 0.0001 M NADPH CHEBI:16474 1.1.1.213;4009 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003425 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADP+ + 3alpha-Hydroxy-5beta-androstan-17-one = NADPH + H+ + 5beta-Androstane-3,17-dione 3e-07 M 5beta-androstane-3,17-dione CHEBI:16985 1.1.1.213;4009 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003426 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 5e-06 M 5alpha-androstane-3,17-dione CHEBI:15994 1.1.1.213;2409 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003427 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.00366666667 s^(-1) 1.1.1.213;2409 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003428 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.0001 M NADPH CHEBI:16474 1.1.1.213;2409 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003429 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADPH + H+ + 5beta-Dihydrotestosterone = NADP+ + Androstanediol 0.0001 M NADPH CHEBI:16474 1.1.1.213;10109 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003430 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADPH + H+ + 5beta-Dihydrotestosterone = NADP+ + Androstanediol 0.000167 s^(-1) 1.1.1.213;10109 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003431 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADPH + H+ + 5beta-Dihydrotestosterone = NADP+ + Androstanediol 5e-06 M 5beta-Dihydrotestosterone CHEBI:NONE_161832 1.1.1.213;10109 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003432 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 3e-07 M flufenamic acid CHEBI:42638 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003433 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.0001 M naproxen CHEBI:7476 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003434 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 6e-07 M naproxen CHEBI:7476 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003435 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 1.1e-05 M ibuprofen CHEBI:5855 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003436 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.0001 M ibuprofen CHEBI:5855 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003437 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.0001 M indomethacin CHEBI:100173 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003438 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 4.3e-05 M indomethacin CHEBI:100173 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003439 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.0001 M Aspirin CHEBI:NONE_161833 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003440 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.000113 M Aspirin CHEBI:NONE_161833 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003441 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.0001 M dexamethasone CHEBI:41879 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003442 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.001079 M dexamethasone CHEBI:41879 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003443 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 5e-06 M 3alpha-Hydroxy-5beta-cholanic acid CHEBI:NONE_161834 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003444 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 2e-08 M 3alpha-Hydroxy-5beta-cholanic acid CHEBI:NONE_161834 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003445 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 3e-08 M ursodeoxycholic acid CHEBI:9907 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003446 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 5e-06 M ursodeoxycholic acid CHEBI:9907 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003447 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 4e-08 M 3-oxo-5beta-cholanate CHEBI:11867 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003448 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 5e-06 M 3-oxo-5beta-cholanate CHEBI:11867 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003449 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 1.1e-07 M chenodeoxycholic acid CHEBI:16755 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003450 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 5e-06 M chenodeoxycholic acid CHEBI:16755 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003451 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 5e-06 M deoxycholic acid CHEBI:28834 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003452 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 3.9e-06 M deoxycholic acid CHEBI:28834 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003453 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 1.3e-05 M cholic acid CHEBI:16359 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003454 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 5e-06 M cholic acid CHEBI:16359 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003455 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 3.2e-05 M indomethacin CHEBI:100173 1.1.1.213;2409 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003456 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.00107 M dexamethasone CHEBI:41879 1.1.1.213;2409 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003457 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 3e-08 M 3alpha-Hydroxy-5beta-cholanic acid CHEBI:NONE_161834 1.1.1.213;2409 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003458 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 5e-08 M 3-oxo-5beta-cholanate CHEBI:11867 1.1.1.213;2409 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003459 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 1.1e-07 M chenodeoxycholic acid CHEBI:16755 1.1.1.213;2409 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003460 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Ki NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 2.6e-06 M deoxycholic acid CHEBI:28834 1.1.1.213;2409 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK AAP, ASD 0 220003461 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.0023 M NADP+ CHEBI:NONE_161814 1.3.1.20;2409 wildtype isozyme DD2; 25.0; 7.4|std.dev:|Tissue:Hep-G2 cell|Cellular Location:unknown Y Y PubMed:9578563 SabioRK AAP, ASD 0 220003462 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.00666666667 s^(-1) 1.3.1.20;2409 wildtype isozyme DD2; 25.0; 7.4|std.dev:|Tissue:Hep-G2 cell|Cellular Location:unknown Y Y PubMed:9578563 SabioRK AAP, ASD 0 220003463 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat/Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 1833.33333 M^(-1)*s^(-1) androsterone CHEBI:16032 1.3.1.20;2409 wildtype isozyme DD2; 25.0; 7.4|std.dev:|Tissue:Hep-G2 cell|Cellular Location:unknown Y Y PubMed:9578563 SabioRK AAP, ASD 0 220003464 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 3.5e-06 M androsterone CHEBI:16032 1.3.1.20;2409 wildtype isozyme DD2; 25.0; 7.4|std.dev:|Tissue:Hep-G2 cell|Cellular Location:unknown Y Y PubMed:9578563 SabioRK AAP, ASD 0 220003465 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 11.0 s^(-1) 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003466 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.25 M NADP+ CHEBI:NONE_161814 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003467 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 490.0 M (s)-indan-1-ol CHEBI:NONE_161458 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003468 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 2.2 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.3.1.20;2409 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003469 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.25 M NADP+ CHEBI:NONE_161814 1.3.1.20;2409 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003470 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.4 s^(-1) 1.3.1.20;2409 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003471 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate + H+ + NADPH = NADP+ + 9alpha,11beta-Prostaglandin F2 0.25 M NADP+ CHEBI:NONE_161814 1.3.1.20;7733 wildtype DD2; 25.0; 10.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003472 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate + H+ + NADPH = NADP+ + 9alpha,11beta-Prostaglandin F2 5.0 s^(-1) 1.3.1.20;7733 wildtype DD2; 25.0; 10.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003473 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate + H+ + NADPH = NADP+ + 9alpha,11beta-Prostaglandin F2 220.0 M 9alpha,11beta-Prostaglandin F2 CHEBI:NONE_161816 1.3.1.20;7733 wildtype DD2; 25.0; 10.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003474 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 2.0 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.3.1.20;2409 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003475 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.08 M lithocholic acid CHEBI:16325 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003476 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 1.0 M (s)-indan-1-ol CHEBI:NONE_161458 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003477 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.07 M lithocholic acid CHEBI:16325 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003478 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.06 M ursodeoxycholic acid CHEBI:9907 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003479 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.08 M ursodeoxycholic acid CHEBI:9907 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003480 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.15 M chenodeoxycholic acid CHEBI:16755 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003481 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.13 M chenodeoxycholic acid CHEBI:16755 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003482 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.7 M flufenamic acid CHEBI:42638 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003483 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.9 M flufenamic acid CHEBI:42638 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003484 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 1.6 M medroxyprogesterone acetate CHEBI:6716 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003485 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 1.7 M medroxyprogesterone acetate CHEBI:6716 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003486 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 3.5 M Hexestrol CHEBI:NONE_161835 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003487 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 2.8 M Hexestrol CHEBI:NONE_161835 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003488 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 10.0 M ibuprofen CHEBI:5855 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003489 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 6.9 M ibuprofen CHEBI:5855 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003490 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 18.0 M phenolphthalein CHEBI:34914 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003491 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 12.0 M phenolphthalein CHEBI:34914 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003492 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 75.0 M indomethacin CHEBI:100173 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003493 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate + H+ + NADPH = NADP+ + 9alpha,11beta-Prostaglandin F2 208.0 M 9alpha,11beta-Prostaglandin F2 CHEBI:NONE_161816 1.3.1.20;7733 wildtype DD2; 25.0; 10.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003494 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat (5Z,13E)-(15S)-9alpha,15-Dihydroxy-11-oxoprosta-5,13-dienoate + H+ + NADPH = NADP+ + 9alpha,11beta-Prostaglandin F2 25.0 s^(-1) 1.3.1.20;7733 wildtype DD2; 25.0; 10.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003495 curatus P52895 1646 AKR1C2 Homo sapiens 9606 IC50 NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 70.0 M indomethacin CHEBI:100173 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK AAP, ASD 0 220003496 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat/Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 150.0 M^(-1)*s^(-1) 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003497 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.0023 M NADPH CHEBI:16474 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003498 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Vmax H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 1.04e-07 mol*s^(-1)*g^(-1) 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:1.36667E-8|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003499 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.00383333333 s^(-1) 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003500 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 2.6e-05 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:6.6E-6|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003501 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.05 mg/ml Enzyme CHEBI:NONE_161823 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003502 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Vmax NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 6.3e-07 mol*s^(-1)*g^(-1) 1.1.1.213;2409 wildtype AKR1C2; 25.0; 7.0|std.dev:2.5E-8|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003503 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat/Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 3700.0 M^(-1)*s^(-1) 5alpha-androstane-3,17-dione CHEBI:15994 1.1.1.213;2409 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003504 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.0002 M NADPH CHEBI:16474 1.1.1.213;2409 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003505 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 6.26e-06 M 5alpha-androstane-3,17-dione CHEBI:15994 1.1.1.213;2409 wildtype AKR1C2; 25.0; 7.0|std.dev:1.59E-6|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003506 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.0231666667 s^(-1) 1.1.1.213;2409 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003507 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.002 M NADP+ CHEBI:NONE_161814 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003508 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.004 s^(-1) 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003509 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 2.2e-05 M 5alpha-androstane-3alpha,17beta-diol CHEBI:36713 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:7.5E-6|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003510 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat/Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 183.333333 M^(-1)*s^(-1) 5alpha-androstane-3alpha,17beta-diol CHEBI:36713 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003511 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Vmax H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 1.1e-07 mol*s^(-1)*g^(-1) 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:2.06667E-8|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003512 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.002 M NADP+ CHEBI:NONE_161814 1.1.1.213;2409 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003513 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Vmax NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 1.88e-07 mol*s^(-1)*g^(-1) 1.1.1.213;2409 wildtype AKR1C2; 25.0; 7.0|std.dev:1.0E-8|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003514 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 9.73e-06 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1.213;2409 wildtype AKR1C2; 25.0; 7.0|std.dev:1.88E-6|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003515 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat/Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 716.666667 M^(-1)*s^(-1) 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1.213;2409 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003516 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.007 s^(-1) 1.1.1.213;2409 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003517 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 1.1e-06 M 5alpha-Dihydrotestosterone CHEBI:NONE_161826 1.1.1.213;7911 wildtype; 37.0; 7.5|std.dev:2.0E-7|Tissue:prostate|Cellular Location:unknown Y Y PubMed:11514561 SabioRK AAP, ASD 0 220003518 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.0001 M NADPH CHEBI:16474 1.1.1.213;7911 wildtype; 37.0; 7.5|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:11514561 SabioRK AAP, ASD 0 220003519 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.025 s^(-1) 1.1.1.213;7911 wildtype; 37.0; 7.5|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:11514561 SabioRK AAP, ASD 0 220003520 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat/Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 21666.6667 M^(-1)*s^(-1) 5alpha-Dihydrotestosterone CHEBI:NONE_161826 1.1.1.213;7911 wildtype; 37.0; 7.5|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:11514561 SabioRK AAP, ASD 0 220003521 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat/Km NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 183.333333 M^(-1)*s^(-1) testosterone CHEBI:17347 1.1.1.213;1917 wildtype; 37.0; 7.5|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:11514561 SabioRK AAP, ASD 0 220003522 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 6.7e-07 M testosterone CHEBI:17347 1.1.1.213;1917 wildtype; 37.0; 7.5|std.dev:1.8E-7|Tissue:prostate|Cellular Location:unknown Y Y PubMed:11514561 SabioRK AAP, ASD 0 220003523 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.0001 M NADP+ CHEBI:NONE_161814 1.1.1.213;1917 wildtype; 37.0; 7.5|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:11514561 SabioRK AAP, ASD 0 220003524 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.000118 s^(-1) 1.1.1.213;1917 wildtype; 37.0; 7.5|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:11514561 SabioRK AAP, ASD 0 220003525 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat/Km NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 816.666667 M^(-1)*s^(-1) androst-4-ene-3,17-dione CHEBI:16422 1.1.1.213;1917 wildtype; 37.0; 7.5|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:11514561 SabioRK AAP, ASD 0 220003526 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 1.38e-06 M androst-4-ene-3,17-dione CHEBI:16422 1.1.1.213;1917 wildtype; 37.0; 7.5|std.dev:3.1E-7|Tissue:prostate|Cellular Location:unknown Y Y PubMed:11514561 SabioRK AAP, ASD 0 220003527 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.00111666667 s^(-1) 1.1.1.213;1917 wildtype; 37.0; 7.5|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:11514561 SabioRK AAP, ASD 0 220003528 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.0001 M NADPH CHEBI:16474 1.1.1.213;1917 wildtype; 37.0; 7.5|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:11514561 SabioRK AAP, ASD 0 220003529 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + Indan-1-ol = NADPH + Indanone + H+ 0.163333333 s^(-1) 1.1.1.112;3366 wildtype isoform AKR1C2; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003530 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + Indan-1-ol = NADPH + Indanone + H+ 0.0023 M NADP+ CHEBI:NONE_161814 1.1.1.112;3366 wildtype isoform AKR1C2; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003531 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat/Km NADP+ + Indan-1-ol = NADPH + Indanone + H+ 183.333333 M^(-1)*s^(-1) indan-1-ol CHEBI:16697 1.1.1.112;3366 wildtype isoform AKR1C2; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003532 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADP+ + Indan-1-ol = NADPH + Indanone + H+ 0.00094 M indan-1-ol CHEBI:16697 1.1.1.112;3366 wildtype isoform AKR1C2; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003533 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat/Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 1833.33333 M^(-1)*s^(-1) 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1.213;2409 wildtype isoform AKR1C2; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003534 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.00666666667 s^(-1) 1.1.1.213;2409 wildtype isoform AKR1C2; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003535 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.0023 M NADP+ CHEBI:NONE_161814 1.1.1.213;2409 wildtype isoform AKR1C2; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003536 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 3.5e-06 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1.213;2409 wildtype isoform AKR1C2; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003537 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat/Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 11333.3333 M^(-1)*s^(-1) 5alpha-Dihydrotestosterone CHEBI:NONE_161826 1.1.1;7911 wildtype AKR1C2; -; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK AAP, ASD 0 220003538 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.0024 mg/ml Enzyme CHEBI:NONE_161823 1.1.1;7911 wildtype AKR1C2; -; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK AAP, ASD 0 220003539 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.033 s^(-1) 1.1.1;7911 wildtype AKR1C2; -; 7.0|std.dev:0.002|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK AAP, ASD 0 220003540 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 2.9e-06 M 5alpha-Dihydrotestosterone CHEBI:NONE_161826 1.1.1;7911 wildtype AKR1C2; -; 7.0|std.dev:2.0E-7|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK AAP, ASD 0 220003541 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NAD+ + 5alpha-Androstane-3alpha-ol-17-one = NADH + 5alpha-Androstane-3,17-dione + H+ 9.3 M androsterone CHEBI:16032 1.1.1.357;2408 wildtype; 37.0; 7.0|std.dev:0.9|Tissue:-|Cellular Location:unknown Y Y PubMed:22437839 SabioRK AAP, ASD 0 220003542 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat/Km NAD+ + 5alpha-Androstane-3alpha-ol-17-one = NADH + 5alpha-Androstane-3,17-dione + H+ 2300.0 M^(-1)*s^(-1) androsterone CHEBI:16032 1.1.1.357;2408 wildtype; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:22437839 SabioRK AAP, ASD 0 220003543 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NAD+ + 5alpha-Androstane-3alpha-ol-17-one = NADH + 5alpha-Androstane-3,17-dione + H+ 0.0217 s^(-1) 1.1.1.357;2408 wildtype; 37.0; 7.0|std.dev:8.0E-4|Tissue:-|Cellular Location:unknown Y Y PubMed:22437839 SabioRK AAP, ASD 0 220003544 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NAD+ + 5alpha-Androstane-3alpha-ol-17-one = NADH + 5alpha-Androstane-3,17-dione + H+ 2.3 M NAD+ CHEBI:NONE_161836 1.1.1.357;2408 wildtype; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:22437839 SabioRK AAP, ASD 0 220003545 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat/Km NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one = H+ + NADH + 5beta-Androstane-3,17-dione 490.0 M^(-1)*s^(-1) 3alpha-hydroxy-5beta-androstan-17-one CHEBI:28195 1.1.1.357;4008 wildtype; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:22437839 SabioRK AAP, ASD 0 220003546 curatus P52895 1646 AKR1C2 Homo sapiens 9606 kcat NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one = H+ + NADH + 5beta-Androstane-3,17-dione 0.014 s^(-1) 1.1.1.357;4008 wildtype; 37.0; 7.0|std.dev:0.001|Tissue:-|Cellular Location:unknown Y Y PubMed:22437839 SabioRK AAP, ASD 0 220003547 curatus P52895 1646 AKR1C2 Homo sapiens 9606 Km NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one = H+ + NADH + 5beta-Androstane-3,17-dione 29.0 M 3alpha-hydroxy-5beta-androstan-17-one CHEBI:28195 1.1.1.357;4008 wildtype; 37.0; 7.0|std.dev:4.2|Tissue:-|Cellular Location:unknown Y Y PubMed:22437839 SabioRK AAP, ASD 0 220003548 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one = H+ + NADH + 5beta-Androstane-3,17-dione 2.3 M NAD+ CHEBI:NONE_161836 1.1.1.357;4008 wildtype; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:22437839 SabioRK AAP, ASD 0 220003549 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 19.2 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.357;7911 wildtype 3alpha HSD type II; 37.0; 7.4|std.dev:3.3|Tissue:-|Cellular Location:cytosol Y Y PubMed:7650035 SabioRK AAP, ASD 0 220003596 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Vmax H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.13 mol*s^(-1)*g^(-1) 1.1.1.357;7911 wildtype 3alpha HSD type II; 37.0; 7.4|std.dev:0.02|Tissue:-|Cellular Location:cytosol Y Y PubMed:7650035 SabioRK AAP, ASD 0 220003597 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 1.0 M NADPH CHEBI:16474 1.1.1.357;7911 wildtype 3alpha HSD type II; 37.0; 7.4|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:7650035 SabioRK AAP, ASD 0 220003598 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat/Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 96.5 M^(-1)*s^(-1) 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003599 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.0002 M NADPH CHEBI:16474 1.1.1.213;7911 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003600 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Vmax H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 4.08e-08 mol*s^(-1)*g^(-1) 1.1.1.213;7911 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:9.83333E-9|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003601 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.00183333333 s^(-1) 1.1.1.213;7911 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:5.0E-4|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003602 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 1.9e-05 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:7.2E-6|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003603 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.008 s^(-1) 1.1.1.213;2409 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:3.33333E-4|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003604 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat/Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 1900.0 M^(-1)*s^(-1) 5alpha-androstane-3,17-dione CHEBI:15994 1.1.1.213;2409 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003605 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Vmax NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 1.85e-07 mol*s^(-1)*g^(-1) 1.1.1.213;2409 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:6.83333E-9|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003606 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.0002 M NADPH CHEBI:16474 1.1.1.213;2409 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003607 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 4.22e-06 M 5alpha-androstane-3,17-dione CHEBI:15994 1.1.1.213;2409 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:6.6E-7|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003608 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration 9,10-Phenanthroquinone + H+ + NADPH = NADP+ + Phenanthrene-9,10-diol 0.0002 M NADPH CHEBI:16474 1.1.1.213;7755 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003609 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Vmax 9,10-Phenanthroquinone + H+ + NADPH = NADP+ + Phenanthrene-9,10-diol 8.97e-06 mol*s^(-1)*g^(-1) 1.1.1.213;7755 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:6.0E-7|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003610 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Km 9,10-Phenanthroquinone + H+ + NADPH = NADP+ + Phenanthrene-9,10-diol 2.06e-05 M 9,10-phenanthroquinone CHEBI:37454 1.1.1.213;7755 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:5.8E-6|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003611 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat 9,10-Phenanthroquinone + H+ + NADPH = NADP+ + Phenanthrene-9,10-diol 0.39 s^(-1) 1.1.1.213;7755 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:0.0266667|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003612 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat/Km 9,10-Phenanthroquinone + H+ + NADPH = NADP+ + Phenanthrene-9,10-diol 18933.3333 M^(-1)*s^(-1) 9,10-phenanthroquinone CHEBI:37454 1.1.1.213;7755 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003613 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat/Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 1078.33333 M^(-1)*s^(-1) p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.213;6758 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003614 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 8.73e-05 M p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.213;6758 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:1.08E-5|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003615 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Vmax NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 2.17e-06 mol*s^(-1)*g^(-1) 1.1.1.213;6758 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:5.0E-8|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003616 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0002 M NADPH CHEBI:16474 1.1.1.213;6758 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003617 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0941666667 s^(-1) 1.1.1.213;6758 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:0.00216667|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003618 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 2.62e-05 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:3.1E-6|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003619 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.0023 M NADPH CHEBI:16474 1.1.1.213;7911 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003620 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat/Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 114.5 M^(-1)*s^(-1) 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003621 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Vmax H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 6.97e-08 mol*s^(-1)*g^(-1) 1.1.1.213;7911 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:4.33333E-9|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003622 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.003 s^(-1) 1.1.1.213;7911 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:1.66667E-4|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003623 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.0009 s^(-1) 1.1.1.213;1917 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:1.33333E-4|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003624 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat/Km NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 75.6666667 M^(-1)*s^(-1) testosterone CHEBI:17347 1.1.1.213;1917 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003625 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Km NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 1.19e-05 M testosterone CHEBI:17347 1.1.1.213;1917 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:4.4E-6|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003626 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.0023 M NADP+ CHEBI:NONE_161814 1.1.1.213;1917 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003627 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Vmax NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 2.08e-08 mol*s^(-1)*g^(-1) 1.1.1.213;1917 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:3.0E-9|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003628 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.0023 M NADP+ CHEBI:NONE_161814 1.1.1.213;2409 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003629 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 4.84e-05 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1.213;2409 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:1.41E-5|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003630 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Vmax NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 8.5e-09 mol*s^(-1)*g^(-1) 1.1.1.213;2409 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:2.5E-9|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003631 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat/Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 7.83333333 M^(-1)*s^(-1) 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1.213;2409 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003632 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.000367 s^(-1) 1.1.1.213;2409 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:1.16667E-4|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK AAP, ASD 0 220003633 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 1.75 mg/ml Enzyme CHEBI:NONE_161823 1.1.1.64;1917 wildtype; 37.0; 7.4|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9927279 SabioRK AAP, ASD 0 220003634 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.1 M androst-4-ene-3,17-dione CHEBI:16422 1.1.1.64;1917 wildtype; 37.0; 7.4|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9927279 SabioRK AAP, ASD 0 220003635 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Vmax NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 30.0 mol*s^(-1)*g^(-1) 1.1.1.64;1917 wildtype; 37.0; 7.4|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9927279 SabioRK AAP, ASD 0 220003636 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 1.0 M NADPH CHEBI:16474 1.1.1.64;1917 wildtype; 37.0; 7.4|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9927279 SabioRK AAP, ASD 0 220003637 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 2.62e-05 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:3.1E-6|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003638 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat/Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 100.0 M^(-1)*s^(-1) 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003639 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.05 mg/ml Enzyme CHEBI:NONE_161823 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003640 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.00416666667 s^(-1) 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003641 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Vmax H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 6.97e-08 mol*s^(-1)*g^(-1) 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:4.33333E-9|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003642 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.0023 M NADPH CHEBI:16474 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003643 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.00433333333 s^(-1) 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003644 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 0.0002 M NADPH CHEBI:16474 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003645 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 1.98e-05 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:7.2E-6|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003646 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat/Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 220.0 M^(-1)*s^(-1) 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003647 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Vmax H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 1.18e-07 mol*s^(-1)*g^(-1) 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:1.81667E-8|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003648 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.000817 s^(-1) 1.1.1.239;1917 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003649 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.05 mg/ml Enzyme CHEBI:NONE_161823 1.1.1.239;1917 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003650 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Vmax NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 2.23e-08 mol*s^(-1)*g^(-1) 1.1.1.239;1917 wildtype AKR1C3; 25.0; 7.0|std.dev:3.0E-9|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003651 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Km NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 2.43e-05 M testosterone CHEBI:17347 1.1.1.239;1917 wildtype AKR1C3; 25.0; 7.0|std.dev:7.5E-6|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003652 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 0.0023 M NADP+ CHEBI:NONE_161814 1.1.1.239;1917 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003653 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat/Km NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 33.3333333 M^(-1)*s^(-1) testosterone CHEBI:17347 1.1.1.239;1917 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK AAP, ASD 0 220003654 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + Indan-1-ol = NADPH + Indanone + H+ 0.0023 M NADP+ CHEBI:NONE_161814 1.1.1.112;3366 wildtype isoform AKR1C3; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003655 curatus P42330 8644 AKR1C3 Homo sapiens 9606 Km NADP+ + Indan-1-ol = NADPH + Indanone + H+ 0.0014 M indan-1-ol CHEBI:16697 1.1.1.112;3366 wildtype isoform AKR1C3; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003656 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat NADP+ + Indan-1-ol = NADPH + Indanone + H+ 0.0866666667 s^(-1) 1.1.1.112;3366 wildtype isoform AKR1C3; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003657 curatus P42330 8644 AKR1C3 Homo sapiens 9606 kcat/Km NADP+ + Indan-1-ol = NADPH + Indanone + H+ 61.6666667 M^(-1)*s^(-1) indan-1-ol CHEBI:16697 1.1.1.112;3366 wildtype isoform AKR1C3; 25.0; 7.4|std.dev:-|Tissue:Hep-G2 cell|Cellular Location:cytoplasm Y Y PubMed:15026176 SabioRK AAP, ASD 0 220003658 curatus P33261 1557 CYP2C19 Homo sapiens 9606 Km O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 8e-06 M 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide CHEBI:NONE_161839 1.14.13;7240 wildtype 2C19; 28.0; 7.4|std.dev:3.0E-6|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK AAP, DGA, ASD 0 220003659 curatus P33261 1557 CYP2C19 Homo sapiens 9606 kcat O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 0.266666667 s^(-1) 1.14.13;7240 wildtype 2C19; 28.0; 7.4|std.dev:0.0333333|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK AAP, DGA, ASD 0 220003660 curatus P33261 1557 CYP2C19 Homo sapiens 9606 kcat/Km O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 33333.3333 M^(-1)*s^(-1) 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide CHEBI:NONE_161839 1.14.13;7240 wildtype 2C19; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK AAP, DGA, ASD 0 220003661 curatus P33260 1562 CYP2C18 Homo sapiens 9606 kcat/Km O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 133333.333 M^(-1)*s^(-1) 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide CHEBI:NONE_161839 1.14.14.1;7240 wildtype 2C18; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK AAP, ASD 0 220003662 curatus P33260 1562 CYP2C18 Homo sapiens 9606 kcat O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 0.666666667 s^(-1) 1.14.14.1;7240 wildtype 2C18; 28.0; 7.4|std.dev:0.133333|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK AAP, ASD 0 220003663 curatus P33260 1562 CYP2C18 Homo sapiens 9606 Km O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 5e-06 M 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide CHEBI:NONE_161839 1.14.14.1;7240 wildtype 2C18; 28.0; 7.4|std.dev:3.0E-6|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK AAP, ASD 0 220003664 curatus P18283 2877 GPX2 Homo sapiens 9606 concentration Reduced glutathione + Cumene hydroperoxide = Oxidized glutathione + 2-Phenyl-2-propanol + H2O 0.00025 M cumene hydroperoxide CHEBI:NONE_148503 1.11.1.9;10575 wildtype Selenium-dependent; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:6882790 SabioRK AAP, ASD 0 220003665 curatus P18283 2877 GPX2 Homo sapiens 9606 Km Reduced glutathione + Cumene hydroperoxide = Oxidized glutathione + 2-Phenyl-2-propanol + H2O 0.00133 M Reduced glutathione CHEBI:NONE_161821 1.11.1.9;10575 wildtype Selenium-dependent; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:6882790 SabioRK AAP, ASD 0 220003666 curatus P18283 2877 GPX2 Homo sapiens 9606 Km Reduced glutathione + Cumene hydroperoxide = Oxidized glutathione + 2-Phenyl-2-propanol + H2O 6e-06 M cumene hydroperoxide CHEBI:NONE_148503 1.11.1.9;10575 wildtype Selenium-dependent; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:6882790 SabioRK AAP, ASD 0 220003667 curatus P18283 2877 GPX2 Homo sapiens 9606 concentration Reduced glutathione + Cumene hydroperoxide = Oxidized glutathione + 2-Phenyl-2-propanol + H2O 0.001 M Reduced glutathione CHEBI:NONE_161821 1.11.1.9;10575 wildtype Selenium-dependent; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:6882790 SabioRK AAP, ASD 0 220003668 curatus P18283 2877 GPX2 Homo sapiens 9606 concentration Reduced glutathione + Cumene hydroperoxide = Oxidized glutathione + 2-Phenyl-2-propanol + H2O 0.00025 M cumene hydroperoxide CHEBI:NONE_148503 1.11.1.9;10575 wildtype Non-selenium-dependent; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:6882790 SabioRK AAP, ASD 0 220003669 curatus P18283 2877 GPX2 Homo sapiens 9606 concentration Reduced glutathione + Cumene hydroperoxide = Oxidized glutathione + 2-Phenyl-2-propanol + H2O 0.001 M Reduced glutathione CHEBI:NONE_161821 1.11.1.9;10575 wildtype Non-selenium-dependent; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:6882790 SabioRK AAP, ASD 0 220003670 curatus P18283 2877 GPX2 Homo sapiens 9606 Km Reduced glutathione + Cumene hydroperoxide = Oxidized glutathione + 2-Phenyl-2-propanol + H2O 0.00022 M Reduced glutathione CHEBI:NONE_161821 1.11.1.9;10575 wildtype Non-selenium-dependent; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:6882790 SabioRK AAP, ASD 0 220003671 curatus P18283 2877 GPX2 Homo sapiens 9606 concentration Reduced glutathione + t-Butylhydroperoxide = Oxidized glutathione + t-Butanol + H2O 0.00025 M t-Butylhydroperoxide CHEBI:NONE_161840 1.11.1.9;10590 wildtype Selenium-dependent; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:6882790 SabioRK AAP, ASD 0 220003672 curatus P18283 2877 GPX2 Homo sapiens 9606 Km Reduced glutathione + t-Butylhydroperoxide = Oxidized glutathione + t-Butanol + H2O 0.00133 M Reduced glutathione CHEBI:NONE_161821 1.11.1.9;10590 wildtype Selenium-dependent; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:6882790 SabioRK AAP, ASD 0 220003673 curatus P18283 2877 GPX2 Homo sapiens 9606 concentration Reduced glutathione + t-Butylhydroperoxide = Oxidized glutathione + t-Butanol + H2O 0.001 M Reduced glutathione CHEBI:NONE_161821 1.11.1.9;10590 wildtype Selenium-dependent; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:6882790 SabioRK AAP, ASD 0 220003674 curatus P18283 2877 GPX2 Homo sapiens 9606 Km Reduced glutathione + t-Butylhydroperoxide = Oxidized glutathione + t-Butanol + H2O 2.4e-05 M t-Butylhydroperoxide CHEBI:NONE_161840 1.11.1.9;10590 wildtype Selenium-dependent; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:6882790 SabioRK AAP, ASD 0 220003675 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 0.0002 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C226A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003676 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C226A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003677 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + Menadione + H+ = Menadiol + NADP+ 8.9 s^(-1) 1.1.1.184;9874 mutant C226A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003678 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003679 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 2.5e-05 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003680 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + Menadione + H+ = Menadiol + NADP+ 8.4 s^(-1) 1.1.1.184;9874 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003681 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 2.2e-05 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003682 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + Menadione + H+ = Menadiol + NADP+ 5.9 s^(-1) 1.1.1.184;9874 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003683 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003684 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + Menadione + H+ = Menadiol + NADP+ 6.6 s^(-1) 1.1.1.184;9874 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003685 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 2.4e-05 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003686 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003687 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C227A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003688 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + Menadione + H+ = Menadiol + NADP+ 0.5 s^(-1) 1.1.1.184;9874 mutant C227A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003689 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 0.00087 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C227A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003690 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C227S; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003691 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + Menadione + H+ = Menadiol + NADP+ 0.8 s^(-1) 1.1.1.184;9874 mutant C227S; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003692 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 0.0008 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C227S; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003693 curatus P16152 873 CBR1 Homo sapiens 9606 Km H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 0.00023 M 4-benzoylpyridine CHEBI:NONE_148506 1.1.1.184;11767 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003694 curatus P16152 873 CBR1 Homo sapiens 9606 kcat H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 3.7 s^(-1) 1.1.1.184;11767 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003695 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 5e-05 M NADPH CHEBI:16474 1.1.1.184;11767 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003696 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 5e-05 M NADPH CHEBI:16474 1.1.1.184;11767 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003697 curatus P16152 873 CBR1 Homo sapiens 9606 Km H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 0.00033 M 4-benzoylpyridine CHEBI:NONE_148506 1.1.1.184;11767 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003698 curatus P16152 873 CBR1 Homo sapiens 9606 kcat H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 4.7 s^(-1) 1.1.1.184;11767 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003699 curatus P16152 873 CBR1 Homo sapiens 9606 Km H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 0.00027 M 4-benzoylpyridine CHEBI:NONE_148506 1.1.1.184;11767 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003700 curatus P16152 873 CBR1 Homo sapiens 9606 kcat H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 5.4 s^(-1) 1.1.1.184;11767 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003701 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 5e-05 M NADPH CHEBI:16474 1.1.1.184;11767 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003702 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.00014 M daunorubicin CHEBI:41977 1.1.1.184;8084 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003703 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;8084 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003704 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + H+ + Daunorubicin = Unknown + NADP+ 1.2 s^(-1) 1.1.1.184;8084 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003705 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;8084 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003706 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.00016 M daunorubicin CHEBI:41977 1.1.1.184;8084 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003707 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + H+ + Daunorubicin = Unknown + NADP+ 1.7 s^(-1) 1.1.1.184;8084 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003708 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;8084 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003709 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.00018 M daunorubicin CHEBI:41977 1.1.1.184;8084 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003710 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + H+ + Daunorubicin = Unknown + NADP+ 1.4 s^(-1) 1.1.1.184;8084 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003711 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.00045 M daunorubicin CHEBI:41977 1.1.1.184;8084 mutant C226A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003712 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;8084 mutant C226A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003713 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.7 s^(-1) 1.1.1.184;8084 mutant C226A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003714 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.00044 M daunorubicin CHEBI:41977 1.1.1.184;8084 mutant C227A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003715 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.12 s^(-1) 1.1.1.184;8084 mutant C227A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003716 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;8084 mutant C227A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003717 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;8084 mutant C227S; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003718 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.00047 M daunorubicin CHEBI:41977 1.1.1.184;8084 mutant C227S; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003719 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.55 s^(-1) 1.1.1.184;8084 mutant C227S; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003720 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadione CHEBI:28869 1.1.1.184;9874 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003721 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 3e-06 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003722 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 3e-06 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003723 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadione CHEBI:28869 1.1.1.184;9874 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003724 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 3e-06 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003725 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadione CHEBI:28869 1.1.1.184;9874 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003726 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadione CHEBI:28869 1.1.1.184;9874 mutant C226A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003727 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 9e-06 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C226A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003728 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadione CHEBI:28869 1.1.1.184;9874 mutant C227A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003729 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 1.3e-05 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C227A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003730 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadione CHEBI:28869 1.1.1.184;9874 mutant C227S; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003731 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 1.2e-05 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C227S; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003732 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 NADPH + Menadione + H+ = Menadiol + NADP+ 1.5e-07 M rutin CHEBI:28527 1.1.1.184;9874 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003733 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003734 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003735 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 NADPH + Menadione + H+ = Menadiol + NADP+ 1.5e-07 M rutin CHEBI:28527 1.1.1.184;9874 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003736 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 NADPH + Menadione + H+ = Menadiol + NADP+ 1.5e-07 M rutin CHEBI:28527 1.1.1.184;9874 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003737 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003738 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 NADPH + Menadione + H+ = Menadiol + NADP+ 1.05e-06 M rutin CHEBI:28527 1.1.1.184;9874 mutant C226A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003739 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C226A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant AAP, ASD 0 220003740 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax 9,10-Phenanthroquinone + H+ + NADPH = NADP+ + Phenanthrene-9,10-diol 0.000317 mol*s^(-1)*g^(-1) 1.1.1.184;7755 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003741 curatus P16152 873 CBR1 Homo sapiens 9606 concentration 9,10-Phenanthroquinone + H+ + NADPH = NADP+ + Phenanthrene-9,10-diol 7.5e-05 M NADPH CHEBI:16474 1.1.1.184;7755 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003742 curatus P16152 873 CBR1 Homo sapiens 9606 Km 9,10-Phenanthroquinone + H+ + NADPH = NADP+ + Phenanthrene-9,10-diol 2e-06 M 9,10-phenanthroquinone CHEBI:37454 1.1.1.184;7755 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003743 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 7.5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003744 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 2e-05 M menadione CHEBI:28869 1.1.1.184;9874 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003745 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax NADPH + Menadione + H+ = Menadiol + NADP+ 6.67e-05 mol*s^(-1)*g^(-1) 1.1.1.184;9874 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003746 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.00015 M daunorubicin CHEBI:41977 1.1.1.184;8084 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003747 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 7.5e-05 M NADPH CHEBI:16474 1.1.1.184;8084 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003748 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax NADPH + H+ + Daunorubicin = Unknown + NADP+ 3.5e-05 mol*s^(-1)*g^(-1) 1.1.1.184;8084 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003749 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + 4-Benzoylpyridine = Unknown + NADP+ 7.5e-05 M NADPH CHEBI:16474 1.1.1.184;8093 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003750 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax NADPH + H+ + 4-Benzoylpyridine = Unknown + NADP+ 9.67e-05 mol*s^(-1)*g^(-1) 1.1.1.184;8093 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003751 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + H+ + 4-Benzoylpyridine = Unknown + NADP+ 0.0002 M 4-benzoylpyridine CHEBI:NONE_148506 1.1.1.184;8093 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003752 curatus P16152 873 CBR1 Homo sapiens 9606 Km H+ + 4-Nitroacetophenone + NADPH = NADP+ + 1-(4-Nitrophenyl)ethanol 0.0013 M 4-nitroacetophenone CHEBI:28735 1.1.1.184;7907 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003753 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + 4-Nitroacetophenone + NADPH = NADP+ + 1-(4-Nitrophenyl)ethanol 7.5e-05 M NADPH CHEBI:16474 1.1.1.184;7907 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003754 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax H+ + 4-Nitroacetophenone + NADPH = NADP+ + 1-(4-Nitrophenyl)ethanol 4.5e-05 mol*s^(-1)*g^(-1) 1.1.1.184;7907 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003755 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 0.0023 M m-Nitrobenzaldehyde CHEBI:NONE_161831 1.1.1.184;6755 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003756 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 8.33e-05 mol*s^(-1)*g^(-1) 1.1.1.184;6755 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003757 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 7.5e-05 M NADPH CHEBI:16474 1.1.1.184;6755 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003758 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0009 M 4-nitrobenzaldehyde CHEBI:66926 1.1.1.184;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003759 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 8.67e-05 mol*s^(-1)*g^(-1) 1.1.1.184;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003760 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 7.5e-05 M NADPH CHEBI:16474 1.1.1.184;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003761 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Pyridine-4-aldehyde = NADP+ + 4-Pyridinemethanol 7.5e-05 M NADPH CHEBI:16474 1.1.1.184;10861 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003762 curatus P16152 873 CBR1 Homo sapiens 9606 Km H+ + NADPH + Pyridine-4-aldehyde = NADP+ + 4-Pyridinemethanol 0.0012 M Pyridine-4-aldehyde CHEBI:NONE_161837 1.1.1.184;10861 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003763 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax H+ + NADPH + Pyridine-4-aldehyde = NADP+ + 4-Pyridinemethanol 0.000157 mol*s^(-1)*g^(-1) 1.1.1.184;10861 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003764 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + Androstanediol 2e-05 mol*s^(-1)*g^(-1) 1.1.1.184;11548 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003765 curatus P16152 873 CBR1 Homo sapiens 9606 Km H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + Androstanediol 0.00049 M 5alpha-Dihydrotestosterone CHEBI:NONE_161826 1.1.1.184;11548 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003766 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + Androstanediol 7.5e-05 M NADPH CHEBI:16474 1.1.1.184;11548 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003767 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 1.32e-05 mol*s^(-1)*g^(-1) 1.1.1.184;2409 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003768 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 7.5e-05 M NADPH CHEBI:16474 1.1.1.184;2409 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003769 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.00019 M 5alpha-androstane-3,17-dione CHEBI:15994 1.1.1.184;2409 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003770 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax NADP+ + 17alpha,20alpha-Dihydroxypregn-4-en-3-one = NADPH + 17alpha-Hydroxyprogesterone + H+ 1.67e-07 mol*s^(-1)*g^(-1) 1.1.1.184;3135 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003771 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADP+ + 17alpha,20alpha-Dihydroxypregn-4-en-3-one = NADPH + 17alpha-Hydroxyprogesterone + H+ 7.5e-05 M NADPH CHEBI:16474 1.1.1.184;3135 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003772 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADP+ + 17alpha,20alpha-Dihydroxypregn-4-en-3-one = NADPH + 17alpha-Hydroxyprogesterone + H+ 2e-05 M 17alpha-hydroxyprogesterone CHEBI:17252 1.1.1.184;3135 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003773 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax NADP+ + Prostaglandin F2alpha = H+ + NADPH + Prostaglandin E2 5.67e-06 mol*s^(-1)*g^(-1) 1.1.1.184;2488 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003774 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADP+ + Prostaglandin F2alpha = H+ + NADPH + Prostaglandin E2 7.5e-05 M NADPH CHEBI:16474 1.1.1.184;2488 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003775 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADP+ + Prostaglandin F2alpha = H+ + NADPH + Prostaglandin E2 0.001 M prostaglandin E2 CHEBI:15551 1.1.1.184;2488 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003776 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax NADP+ + Prostaglandin B1 = Unknown + H+ + NADPH 3.17e-05 mol*s^(-1)*g^(-1) 1.1.1.184;11549 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003777 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADP+ + Prostaglandin B1 = Unknown + H+ + NADPH 5e-05 M prostaglandin B1 CHEBI:27624 1.1.1.184;11549 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003778 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Nonanal + H+ = 1-Nonanol + NADP+ 5e-05 M Nonanal CHEBI:NONE_161838 1.1.1.184;10812 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003779 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Nonanal + H+ = 1-Nonanol + NADP+ 7.5e-05 M NADPH CHEBI:16474 1.1.1.184;10812 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003780 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax NADPH + Nonanal + H+ = 1-Nonanol + NADP+ 5e-07 mol*s^(-1)*g^(-1) 1.1.1.184;10812 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003781 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax H+ + NADPH + Propanal = NADP+ + 1-Propanol 1.67e-07 mol*s^(-1)*g^(-1) 1.1.1.184;6775 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003782 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Propanal = NADP+ + 1-Propanol 7.5e-05 M NADPH CHEBI:16474 1.1.1.184;6775 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003783 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Propanal = NADP+ + 1-Propanol 0.001 M propanal CHEBI:17153 1.1.1.184;6775 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9743262 SabioRK AAP, ASD 0 220003784 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 2.2e-05 M menadiol CHEBI:6746 1.1.1.184;9874 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK AAP, ASD 0 220003785 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK AAP, ASD 0 220003786 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + Menadione + H+ = Menadiol + NADP+ 6.7 s^(-1) 1.1.1.184;9874 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK AAP, ASD 0 220003787 curatus P16152 873 CBR1 Homo sapiens 9606 Km H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 0.00029 M 4-benzoylpyridine CHEBI:NONE_148506 1.1.1.184;11767 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK AAP, ASD 0 220003788 curatus P16152 873 CBR1 Homo sapiens 9606 kcat H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 6.3 s^(-1) 1.1.1.184;11767 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK AAP, ASD 0 220003789 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 5e-05 M NADPH CHEBI:16474 1.1.1.184;11767 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK AAP, ASD 0 220003790 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;8084 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK AAP, ASD 0 220003791 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + H+ + Daunorubicin = Unknown + NADP+ 1.6 s^(-1) 1.1.1.184;8084 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK AAP, ASD 0 220003792 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.00016 M daunorubicin CHEBI:41977 1.1.1.184;8084 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK AAP, ASD 0 220003793 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadione CHEBI:28869 1.1.1.184;9874 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK AAP, ASD 0 220003794 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 3e-06 M NADPH CHEBI:16474 1.1.1.184;9874 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK AAP, ASD 0 220003795 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadiol CHEBI:6746 1.1.1.184;9874 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK AAP, ASD 0 220003796 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 NADPH + Menadione + H+ = Menadiol + NADP+ 1.5e-07 M rutin CHEBI:28527 1.1.1.184;9874 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK AAP, ASD 0 220003797 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 0.0003 M doxorubicin CHEBI:28748 1.1.1.184;12036 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003798 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 0.0002 M NADPH CHEBI:16474 1.1.1.184;12036 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003799 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 5.9e-05 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;12036 wildtype isoform V88; 37.0; 7.4|std.dev:5.0E-6|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003800 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 3.7e-05 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;12036 wildtype isoform I88; 37.0; 7.4|std.dev:4.0E-6|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003801 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 0.0002 M NADPH CHEBI:16474 1.1.1.184;12036 wildtype isoform I88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003802 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 0.0003 M doxorubicin CHEBI:28748 1.1.1.184;12036 wildtype isoform I88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003803 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 5.3e-05 M 5,7,2-Trihydroxyethylrutoside CHEBI:NONE_161842 1.1.1.184;12036 wildtype isoform V88; 37.0; 7.4|std.dev:5.0E-6|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003804 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 3.4e-05 M 5,7,2-Trihydroxyethylrutoside CHEBI:NONE_161842 1.1.1.184;12036 wildtype isoform I88; 37.0; 7.4|std.dev:3.0E-6|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003805 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 4.3e-05 M quercetin CHEBI:16243 1.1.1.184;12036 wildtype isoform V88; 37.0; 7.4|std.dev:3.0E-6|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003806 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 1.9e-05 M quercetin CHEBI:16243 1.1.1.184;12036 wildtype isoform I88; 37.0; 7.4|std.dev:3.0E-6|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003807 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.0002 M NADPH CHEBI:16474 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003808 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.0003 M daunorubicin CHEBI:41977 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003809 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.000219 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:4.0E-6|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003810 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.0002 M NADPH CHEBI:16474 1.1.1.184;12037 wildtype isoform I88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003811 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.000164 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;12037 wildtype isoform I88; 37.0; 7.4|std.dev:5.0E-6|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003812 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.0003 M daunorubicin CHEBI:41977 1.1.1.184;12037 wildtype isoform I88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003813 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.000383 M 5,7,2-Trihydroxyethylrutoside CHEBI:NONE_161842 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:5.0E-6|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003814 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.000214 M 5,7,2-Trihydroxyethylrutoside CHEBI:NONE_161842 1.1.1.184;12037 wildtype isoform I88; 37.0; 7.4|std.dev:3.0E-6|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003815 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 2.5e-05 M quercetin CHEBI:16243 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:3.0E-6|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003816 curatus P16152 873 CBR1 Homo sapiens 9606 IC50 H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 1.4e-05 M quercetin CHEBI:16243 1.1.1.184;12037 wildtype isoform I88; 37.0; 7.4|std.dev:3.0E-6|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003817 curatus P16152 873 CBR1 Homo sapiens 9606 Km H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.0001 M daunorubicin CHEBI:41977 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003818 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 3.02e-06 mol*s^(-1)*g^(-1) 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:2.16667E-7|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003819 curatus P16152 873 CBR1 Homo sapiens 9606 Ki H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 4.5e-05 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:1.8E-5|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003820 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.0004 M daunorubicin CHEBI:41977 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003821 curatus P16152 873 CBR1 Homo sapiens 9606 Ki H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 5e-05 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:1.5E-5|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003822 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax NADPH + Menadione + H+ = Menadiol + NADP+ 3.02e-06 mol*s^(-1)*g^(-1) 1.1.1.184;9874 wildtype isoform V88; 37.0; 7.4|std.dev:2.16667E-7|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003823 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M menadione CHEBI:28869 1.1.1.184;9874 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003824 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.0002 M NADPH CHEBI:16474 1.1.1.184;9874 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003825 curatus P16152 873 CBR1 Homo sapiens 9606 Ki NADPH + Menadione + H+ = Menadiol + NADP+ 3.3e-05 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;9874 wildtype isoform V88; 37.0; 7.4|std.dev:1.7E-5|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003826 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00015 M menadione CHEBI:28869 1.1.1.184;9874 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003827 curatus P16152 873 CBR1 Homo sapiens 9606 Ki NADPH + Menadione + H+ = Menadiol + NADP+ 0.00014 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;9874 wildtype isoform V88; 37.0; 7.4|std.dev:3.7E-5|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003828 curatus P16152 873 CBR1 Homo sapiens 9606 Vmax H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 2.02e-06 mol*s^(-1)*g^(-1) 1.1.1.184;12037 wildtype isoform I88; 37.0; 7.4|std.dev:2.0E-7|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK AAP, ASD 0 220003829 curatus P16152 873 CBR1 Homo sapiens 9606 Km H+ + NADPH + S-Nitrosoglutathione = NADP+ + GSN 3.01e-05 M S-nitrosoglutathione CHEBI:50091 1.1.1.184;11757 wildtype isoenzyme CBR1; 25.0; 6.8|std.dev:3.6E-6|Tissue:-|Cellular Location:cytoplasm Y Y PubMed:18826943 SabioRK AAP, ASD 0 220003830 curatus P16152 873 CBR1 Homo sapiens 9606 kcat/Km H+ + NADPH + S-Nitrosoglutathione = NADP+ + GSN 249166.667 M^(-1)*s^(-1) S-nitrosoglutathione CHEBI:50091 1.1.1.184;11757 wildtype isoenzyme CBR1; 25.0; 6.8|std.dev:-|Tissue:-|Cellular Location:cytoplasm Y Y PubMed:18826943 SabioRK AAP, ASD 0 220003831 curatus P16152 873 CBR1 Homo sapiens 9606 kcat H+ + NADPH + S-Nitrosoglutathione = NADP+ + GSN 7.5 s^(-1) 1.1.1.184;11757 wildtype isoenzyme CBR1; 25.0; 6.8|std.dev:1.41667|Tissue:-|Cellular Location:cytoplasm Y Y PubMed:18826943 SabioRK AAP, ASD 0 220003832 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + S-Nitrosoglutathione = NADP+ + GSN 0.0001 M NADPH CHEBI:16474 1.1.1.184;11757 wildtype isoenzyme CBR1; 25.0; 6.8|std.dev:-|Tissue:-|Cellular Location:cytoplasm Y Y PubMed:18826943 SabioRK AAP, ASD 0 220003833 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.0001 M NADPH CHEBI:16474 1.1.1.184;9874 wildtype isoenzyme CBR1; 25.0; 6.8|std.dev:-|Tissue:-|Cellular Location:cytoplasm Y Y PubMed:18826943 SabioRK AAP, ASD 0 220003834 curatus P16152 873 CBR1 Homo sapiens 9606 kcat/Km NADPH + Menadione + H+ = Menadiol + NADP+ 304533.333 M^(-1)*s^(-1) menadione CHEBI:28869 1.1.1.184;9874 wildtype isoenzyme CBR1; 25.0; 6.8|std.dev:-|Tissue:-|Cellular Location:cytoplasm Y Y PubMed:18826943 SabioRK AAP, ASD 0 220003835 curatus P16152 873 CBR1 Homo sapiens 9606 Km NADPH + Menadione + H+ = Menadiol + NADP+ 2.2e-05 M menadione CHEBI:28869 1.1.1.184;9874 wildtype isoenzyme CBR1; 25.0; 6.8|std.dev:-|Tissue:-|Cellular Location:cytoplasm Y Y PubMed:18826943 SabioRK AAP, ASD 0 220003836 curatus P16152 873 CBR1 Homo sapiens 9606 kcat NADPH + Menadione + H+ = Menadiol + NADP+ 6.7 s^(-1) 1.1.1.184;9874 wildtype isoenzyme CBR1; 25.0; 6.8|std.dev:-|Tissue:-|Cellular Location:cytoplasm Y Y PubMed:18826943 SabioRK AAP, ASD 0 220003837 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 2.28333333 s^(-1) 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytoplasm Y Y PubMed:1537826 SabioRK AAP, DGA, ASD 0 220003838 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00073 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytoplasm Y Y PubMed:1537826 SabioRK AAP, DGA, ASD 0 220003839 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat/Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 3166.66667 M^(-1)*s^(-1) glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytoplasm Y Y PubMed:1537826 SabioRK AAP, DGA, ASD 0 220003840 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0001 M NADPH CHEBI:16474 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytoplasm Y Y PubMed:1537826 SabioRK AAP, DGA, ASD 0 220003841 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat/Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 166666.667 M^(-1)*s^(-1) glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003842 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 2.21666667 s^(-1) 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003843 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 1.3e-05 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003844 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0001 M NADPH CHEBI:16474 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003845 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 3e-06 M p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.21;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003846 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat/Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 883333.333 M^(-1)*s^(-1) p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.21;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003847 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 2.66666667 s^(-1) 1.1.1.21;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003848 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0001 M NADPH CHEBI:16474 1.1.1.21;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003849 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.01 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003850 curatus P15121 231 AKR1B1 Homo sapiens 9606 Ki Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 2.2e-07 M sorbinil CHEBI:102029 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003851 curatus P15121 231 AKR1B1 Homo sapiens 9606 Ki Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 1.7e-08 M tolrestat CHEBI:48549 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003852 curatus P15121 231 AKR1B1 Homo sapiens 9606 Ki Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 3.5e-08 M statil CHEBI:NONE_148517 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003853 curatus P15121 231 AKR1B1 Homo sapiens 9606 Ki NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 1e-07 M sorbinil CHEBI:102029 1.1.1.21;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003854 curatus P15121 231 AKR1B1 Homo sapiens 9606 Ki NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 1.5e-08 M tolrestat CHEBI:48549 1.1.1.21;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003855 curatus P15121 231 AKR1B1 Homo sapiens 9606 Ki NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 1.5e-08 M statil CHEBI:NONE_148517 1.1.1.21;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003856 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 2.28333333 s^(-1) 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003857 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00073 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003858 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 1.78333333 s^(-1) 1.1.1.21;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003859 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 3.2e-05 M p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.21;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003860 curatus P15121 231 AKR1B1 Homo sapiens 9606 Ki Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.000185 M sorbinil CHEBI:102029 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003861 curatus P15121 231 AKR1B1 Homo sapiens 9606 Ki Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 1.5e-07 M tolrestat CHEBI:48549 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003862 curatus P15121 231 AKR1B1 Homo sapiens 9606 Ki Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00024 M statil CHEBI:NONE_148517 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK AAP, DGA, ASD 0 220003863 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 1.1e-05 M p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.21;6758 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK AAP, DGA, ASD 0 220003864 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.00012 M NADPH CHEBI:16474 1.1.1.21;6758 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK AAP, DGA, ASD 0 220003865 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 6.2e-05 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK AAP, DGA, ASD 0 220003866 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00012 M NADPH CHEBI:16474 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK AAP, DGA, ASD 0 220003867 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration NADP+ + Xylitol = D-Xylose + H+ + NADPH 0.00012 M NADPH CHEBI:16474 1.1.1.21;1616 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK AAP, DGA, ASD 0 220003868 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km NADP+ + Xylitol = D-Xylose + H+ + NADPH 0.0163 M D-xylose CHEBI:65327 1.1.1.21;1616 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK AAP, DGA, ASD 0 220003869 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.001 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK AAP, DGA, ASD 0 220003870 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 3.5e-06 M NADPH CHEBI:16474 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK AAP, DGA, ASD 0 220003871 curatus P15121 231 AKR1B1 Homo sapiens 9606 Ki Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 9e-06 M NADP+ CHEBI:NONE_161814 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK AAP, DGA, ASD 0 220003872 curatus P15121 231 AKR1B1 Homo sapiens 9606 Ki Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.23 M glycerol CHEBI:17754 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK AAP, DGA, ASD 0 220003873 curatus P15121 231 AKR1B1 Homo sapiens 9606 Vmax Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 1.02e-05 mol*s^(-1)*g^(-1) 1.1.1.21;6749 wildtype; -; 7.0|std.dev:-|Tissue:brain|Cellular Location:cytoplasm Y Y PubMed:6815419 SabioRK AAP, DGA, ASD 0 220003874 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 8e-05 M NADPH CHEBI:16474 1.1.1.21;6749 wildtype; -; 7.0|std.dev:-|Tissue:brain|Cellular Location:cytoplasm Y Y PubMed:6815419 SabioRK AAP, DGA, ASD 0 220003875 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 6e-05 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; -; 7.0|std.dev:-|Tissue:brain|Cellular Location:cytoplasm Y Y PubMed:6815419 SabioRK AAP, DGA, ASD 0 220003876 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km NADP+ + Xylitol = D-Xylose + H+ + NADPH 0.016 M D-xylose CHEBI:65327 1.1.1.21;1616 wildtype; -; 7.0|std.dev:-|Tissue:brain|Cellular Location:cytoplasm Y Y PubMed:6815419 SabioRK AAP, DGA, ASD 0 220003877 curatus P15121 231 AKR1B1 Homo sapiens 9606 Vmax NADP+ + Xylitol = D-Xylose + H+ + NADPH 7.92e-06 mol*s^(-1)*g^(-1) 1.1.1.21;1616 wildtype; -; 7.0|std.dev:-|Tissue:brain|Cellular Location:cytoplasm Y Y PubMed:6815419 SabioRK AAP, DGA, ASD 0 220003878 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration NADP+ + Xylitol = D-Xylose + H+ + NADPH 8e-05 M NADPH CHEBI:16474 1.1.1.21;1616 wildtype; -; 7.0|std.dev:-|Tissue:brain|Cellular Location:cytoplasm Y Y PubMed:6815419 SabioRK AAP, DGA, ASD 0 220003879 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 1.5e-05 M 4-nitrobenzaldehyde CHEBI:66926 1.1.1.21;6758 wildtype; -; 7.0|std.dev:-|Tissue:brain|Cellular Location:cytoplasm Y Y PubMed:6815419 SabioRK AAP, DGA, ASD 0 220003880 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 8e-05 M NADPH CHEBI:16474 1.1.1.21;6758 wildtype; -; 7.0|std.dev:-|Tissue:brain|Cellular Location:cytoplasm Y Y PubMed:6815419 SabioRK AAP, DGA, ASD 0 220003881 curatus P15121 231 AKR1B1 Homo sapiens 9606 Vmax NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 1.12e-05 mol*s^(-1)*g^(-1) 1.1.1.21;6758 wildtype; -; 7.0|std.dev:-|Tissue:brain|Cellular Location:cytoplasm Y Y PubMed:6815419 SabioRK AAP, DGA, ASD 0 220003882 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km Ethanol + NADP+ = NADPH + H+ + Acetaldehyde 0.067 M acetaldehyde CHEBI:15343 1.1.1.21;49 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003883 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat/Km Ethanol + NADP+ = NADPH + H+ + Acetaldehyde 28.3333333 M^(-1)*s^(-1) acetaldehyde CHEBI:15343 1.1.1.21;49 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003884 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Ethanol + NADP+ = NADPH + H+ + Acetaldehyde 0.0001 M NADPH CHEBI:16474 1.1.1.21;49 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003885 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat Ethanol + NADP+ = NADPH + H+ + Acetaldehyde 1.85 s^(-1) 1.1.1.21;49 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003886 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat H+ + NADPH + Propanal = NADP+ + 1-Propanol 1.86666667 s^(-1) 1.1.1.21;6775 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003887 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km H+ + NADPH + Propanal = NADP+ + 1-Propanol 0.0017 M propanal CHEBI:17153 1.1.1.21;6775 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003888 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration H+ + NADPH + Propanal = NADP+ + 1-Propanol 0.0001 M NADPH CHEBI:16474 1.1.1.21;6775 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003889 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat/Km H+ + NADPH + Propanal = NADP+ + 1-Propanol 1083.33333 M^(-1)*s^(-1) propanal CHEBI:17153 1.1.1.21;6775 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003890 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km NADPH + Phenylglyoxal + H+ = NADP+ + 2-Hydroxyacetophenone 4e-06 M Phenylglyoxal CHEBI:NONE_148519 1.1.1.21;10020 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003891 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat/Km NADPH + Phenylglyoxal + H+ = NADP+ + 2-Hydroxyacetophenone 250000.0 M^(-1)*s^(-1) Phenylglyoxal CHEBI:NONE_148519 1.1.1.21;10020 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003892 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration NADPH + Phenylglyoxal + H+ = NADP+ + 2-Hydroxyacetophenone 0.0001 M NADPH CHEBI:16474 1.1.1.21;10020 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003893 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat NADPH + Phenylglyoxal + H+ = NADP+ + 2-Hydroxyacetophenone 1.0 s^(-1) 1.1.1.21;10020 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003894 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0001 M NADPH CHEBI:16474 1.1.1.21;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003895 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat/Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 883333.333 M^(-1)*s^(-1) 4-nitrobenzaldehyde CHEBI:66926 1.1.1.21;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003896 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 2.66666667 s^(-1) 1.1.1.21;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003897 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 3e-06 M 4-nitrobenzaldehyde CHEBI:66926 1.1.1.21;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:skeletal muscle|Cellular Location:cytosol Y Y PubMed:7599164 SabioRK AAP, DGA, ASD 0 220003898 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 0.2 M NADPH CHEBI:16474 1.1.1.21;6755 wildtype; 30.0; 6.2|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9565553 SabioRK AAP, DGA, ASD 0 220003899 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 343.0 s^(-1) 1.1.1.21;6755 wildtype; 30.0; 6.2|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9565553 SabioRK AAP, DGA, ASD 0 220003900 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 0.014 M m-Nitrobenzaldehyde CHEBI:NONE_161831 1.1.1.21;6755 wildtype; 30.0; 6.2|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9565553 SabioRK AAP, DGA, ASD 0 220003901 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 0.002 M Pyridine-3-aldehyde CHEBI:NONE_161830 1.1.1.21;6776 wildtype; 30.0; 6.2|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9565553 SabioRK AAP, DGA, ASD 0 220003902 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 0.2 M NADPH CHEBI:16474 1.1.1.21;6776 wildtype; 30.0; 6.2|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9565553 SabioRK AAP, DGA, ASD 0 220003903 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 618.0 s^(-1) 1.1.1.21;6776 wildtype; 30.0; 6.2|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9565553 SabioRK AAP, DGA, ASD 0 220003904 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 719.0 s^(-1) 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9565553 SabioRK AAP, DGA, ASD 0 220003905 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.077 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9565553 SabioRK AAP, DGA, ASD 0 220003906 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.2 M NADPH CHEBI:16474 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9565553 SabioRK AAP, DGA, ASD 0 220003907 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat/Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 11000.0 M^(-1)*s^(-1) glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 37.0; 7.4|std.dev:1333.33|Tissue:-|Cellular Location:unknown Y Y PubMed:18087047 SabioRK AAP, DGA, ASD 0 220003908 curatus P15121 231 AKR1B1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 5e-05 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 37.0; 7.4|std.dev:1.0E-5|Tissue:-|Cellular Location:unknown Y Y PubMed:18087047 SabioRK AAP, DGA, ASD 0 220003909 curatus P15121 231 AKR1B1 Homo sapiens 9606 kcat Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.516666667 s^(-1) 1.1.1.21;6749 wildtype; 37.0; 7.4|std.dev:0.0166667|Tissue:-|Cellular Location:unknown Y Y PubMed:18087047 SabioRK AAP, DGA, ASD 0 220003910 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0002 M NADPH CHEBI:16474 1.1.1.21;6749 wildtype; 37.0; 7.4|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:18087047 SabioRK AAP, DGA, ASD 0 220003911 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat/Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 717.0 M^(-1)*s^(-1) glyceraldehyde CHEBI:5445 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003912 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0002 M NADPH CHEBI:16474 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003913 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 1.5 s^(-1) 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003914 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0022 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003915 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0023 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003916 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 1.8 s^(-1) 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003917 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0002 M NADPH CHEBI:16474 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003918 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat/Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 795.0 M^(-1)*s^(-1) glyceraldehyde CHEBI:5445 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003919 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 6.7 s^(-1) 1.1.1.2;6758 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003920 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.00025 M p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.2;6758 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003921 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0002 M NADPH CHEBI:16474 1.1.1.2;6758 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003922 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat/Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 26306.0 M^(-1)*s^(-1) p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.2;6758 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003923 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.00038 M p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.2;6758 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003924 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 4.2 s^(-1) 1.1.1.2;6758 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003925 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat/Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 11060.0 M^(-1)*s^(-1) p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.2;6758 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003926 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0002 M NADPH CHEBI:16474 1.1.1.2;6758 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003927 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.115 M malonic acid CHEBI:30794 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003928 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.004 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003929 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.122 M succinic acid CHEBI:15741 1.1.1.2;6749 mutant 311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003930 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0002 M NADPH CHEBI:16474 1.1.1.2;6749 mutant 311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003931 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.004 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 mutant 311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003932 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.004 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 mutant 308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003933 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0816 M succinic acid CHEBI:15741 1.1.1.2;6749 mutant 308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003934 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0002 M NADPH CHEBI:16474 1.1.1.2;6749 mutant 308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003935 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00283 M glutaric acid CHEBI:17859 1.1.1.2;6749 mutant 308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003936 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0483 M glutaric acid CHEBI:17859 1.1.1.2;6749 mutant 311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003937 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.004 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003938 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0174 M adipic acid CHEBI:30832 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003939 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00502 M adipic acid CHEBI:30832 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003940 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00388 M pimelic acid CHEBI:30531 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003941 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0214 M pimelic acid CHEBI:30531 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003942 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00962 M suberic acid CHEBI:9300 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003943 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00575 M suberic acid CHEBI:9300 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003944 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 1.29e-05 M Dimethylsuccinic acid CHEBI:NONE_161843 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003945 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.000251 M Dimethylsuccinic acid CHEBI:NONE_161843 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003946 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00459 M Tetramethyleneglutaric acid CHEBI:NONE_161844 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003947 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.000417 M Tetramethyleneglutaric acid CHEBI:NONE_161844 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003948 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 3.6e-05 M AL1576 CHEBI:NONE_161845 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003949 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.003 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003950 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.003 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003951 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 9.3e-05 M AL1576 CHEBI:NONE_161845 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003952 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 2.5e-05 M tolrestat CHEBI:48549 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003953 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00051 M tolrestat CHEBI:48549 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003954 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.013 M Ponalrestat CHEBI:NONE_161846 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003955 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0301 M Ponalrestat CHEBI:NONE_161846 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003956 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0024 M sorbinil CHEBI:102029 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003957 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0027 M sorbinil CHEBI:102029 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003958 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0276 M FK366 CHEBI:NONE_161847 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003959 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.028 M FK366 CHEBI:NONE_161847 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003960 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0051 M Zopolrestat CHEBI:NONE_161677 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003961 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0505 M Zopolrestat CHEBI:NONE_161677 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003962 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0673 M Alrestatin CHEBI:NONE_161848 1.1.1.2;6749 mutant R308A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003963 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.119 M Alrestatin CHEBI:NONE_161848 1.1.1.2;6749 mutant R311A; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003964 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Kd Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 4.2e-08 M NADPH CHEBI:16474 1.1.1.2;6749 mutant R311A; 20.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003965 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Kd Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 1e-07 M NADPH CHEBI:16474 1.1.1.2;6749 mutant R308A; 20.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003966 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Kd Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 1.18e-06 M NADP+ CHEBI:NONE_161814 1.1.1.2;6749 mutant R308A; 20.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003967 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Kd Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 4.1e-07 M NADP+ CHEBI:NONE_161814 1.1.1.2;6749 mutant R311A; 20.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK Mutant AAP, ASD 0 220003968 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0001 M NADPH CHEBI:16474 1.1.1.2;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003969 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.00015 M p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.2;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003970 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 9.5 s^(-1) 1.1.1.2;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003971 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 4.7 s^(-1) 1.1.1.2;6755 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003972 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 0.0024 M m-Nitrobenzaldehyde CHEBI:NONE_161831 1.1.1.2;6755 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003973 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 0.0001 M NADPH CHEBI:16474 1.1.1.2;6755 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003974 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0001 M NADPH CHEBI:16474 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003975 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0015 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003976 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 3.0 s^(-1) 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003977 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration H+ + NADPH + Butanal = NADP+ + 1-Butanol 0.0001 M NADPH CHEBI:16474 1.1.1.2;3329 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003978 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat H+ + NADPH + Butanal = NADP+ + 1-Butanol 0.67 s^(-1) 1.1.1.2;3329 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003979 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km H+ + NADPH + Butanal = NADP+ + 1-Butanol 0.0013 M butanal CHEBI:15743 1.1.1.2;3329 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003980 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km H+ + NADPH + Propanal = NADP+ + 1-Propanol 0.0029 M propanal CHEBI:17153 1.1.1.2;6775 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003981 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat H+ + NADPH + Propanal = NADP+ + 1-Propanol 0.46 s^(-1) 1.1.1.2;6775 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003982 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration H+ + NADPH + Propanal = NADP+ + 1-Propanol 0.0001 M NADPH CHEBI:16474 1.1.1.2;6775 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003983 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0005 M p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.2;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003984 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 4e-06 M NADPH CHEBI:16474 1.1.1.2;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003985 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 8e-05 M NADPH CHEBI:16474 1.1.1.2;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003986 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 3e-05 M 5-Phenyl-5-ethylhydantoin CHEBI:NONE_161849 1.1.1.2;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003987 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 5e-05 M phenobarbital CHEBI:8069 1.1.1.2;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK AAP, ASD 0 220003988 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat/Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 2833.33333 M^(-1)*s^(-1) glyceraldehyde CHEBI:5445 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytoplasm Y Y PubMed:1537826 SabioRK AAP, ASD 0 220003989 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0034 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytoplasm Y Y PubMed:1537826 SabioRK AAP, ASD 0 220003990 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 9.33333333 s^(-1) 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytoplasm Y Y PubMed:1537826 SabioRK AAP, ASD 0 220003991 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0001 M NADPH CHEBI:16474 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytoplasm Y Y PubMed:1537826 SabioRK AAP, ASD 0 220003992 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0001 M NADPH CHEBI:16474 1.1.1.2;6749 wildtype AR I; 37.0; 5.3|std.dev:-|Tissue:placenta|Cellular Location:unknown Y Y PubMed:3890957 SabioRK AAP, ASD 0 220003993 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 5e-05 M NADPH CHEBI:16474 1.1.1.2;6749 wildtype AR I; 37.0; 5.3|std.dev:-|Tissue:placenta|Cellular Location:unknown Y Y PubMed:3890957 SabioRK AAP, ASD 0 220003994 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 7e-05 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 wildtype AR I; 37.0; 5.3|std.dev:-|Tissue:placenta|Cellular Location:unknown Y Y PubMed:3890957 SabioRK AAP, ASD 0 220003995 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.02 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 wildtype AR I; 37.0; 5.3|std.dev:-|Tissue:placenta|Cellular Location:unknown Y Y PubMed:3890957 SabioRK AAP, ASD 0 220003996 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km H+ + NADPH + Propanal = NADP+ + 1-Propanol 0.00021 M Propionaldehyde CHEBI:NONE_161850 1.1.1.2;6775 wildtype AR I; 37.0; 5.3|std.dev:-|Tissue:placenta|Cellular Location:unknown Y Y PubMed:3890957 SabioRK AAP, ASD 0 220003997 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration H+ + NADPH + Propanal = NADP+ + 1-Propanol 0.0001 M NADPH CHEBI:16474 1.1.1.2;6775 wildtype AR I; 37.0; 5.3|std.dev:-|Tissue:placenta|Cellular Location:unknown Y Y PubMed:3890957 SabioRK AAP, ASD 0 220003998 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 0.0001 M NADPH CHEBI:16474 1.1.1.2;6776 wildtype AR I; 37.0; 5.3|std.dev:-|Tissue:placenta|Cellular Location:unknown Y Y PubMed:3890957 SabioRK AAP, ASD 0 220003999 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 2e-05 M Pyridine-3-aldehyde CHEBI:NONE_161830 1.1.1.2;6776 wildtype AR I; 37.0; 5.3|std.dev:-|Tissue:placenta|Cellular Location:unknown Y Y PubMed:3890957 SabioRK AAP, ASD 0 220004000 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00294 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 wildtype II; 37.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:6753936 SabioRK AAP, ASD 0 220004001 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0001 M NADPH CHEBI:16474 1.1.1.2;6749 wildtype II; 37.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:6753936 SabioRK AAP, ASD 0 220004002 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km NADP+ + Xylitol = D-Xylose + H+ + NADPH 0.5 M D-xylose CHEBI:65327 1.1.1.2;1616 wildtype II; 37.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:6753936 SabioRK AAP, ASD 0 220004003 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration NADP+ + Xylitol = D-Xylose + H+ + NADPH 0.0001 M NADPH CHEBI:16474 1.1.1.2;1616 wildtype II; 37.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:6753936 SabioRK AAP, ASD 0 220004004 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 0.000606 M Pyridine-3-aldehyde CHEBI:NONE_161830 1.1.1.2;6776 wildtype II; 37.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:6753936 SabioRK AAP, ASD 0 220004005 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 0.0001 M NADPH CHEBI:16474 1.1.1.2;6776 wildtype II; 37.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:6753936 SabioRK AAP, ASD 0 220004006 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.000169 M p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.2;6758 wildtype II; 37.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:6753936 SabioRK AAP, ASD 0 220004007 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0001 M NADPH CHEBI:16474 1.1.1.2;6758 wildtype II; 37.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:6753936 SabioRK AAP, ASD 0 220004008 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km H+ + NADPH + Propanal = NADP+ + 1-Propanol 0.01428 M propanal CHEBI:17153 1.1.1.2;6775 wildtype II; 37.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:6753936 SabioRK AAP, ASD 0 220004009 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration H+ + NADPH + Propanal = NADP+ + 1-Propanol 0.0001 M NADPH CHEBI:16474 1.1.1.2;6775 wildtype II; 37.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:6753936 SabioRK AAP, ASD 0 220004010 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km H+ + NADPH + Butanal = NADP+ + 1-Butanol 0.00769 M butanal CHEBI:15743 1.1.1.2;3329 wildtype II; 37.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:6753936 SabioRK AAP, ASD 0 220004011 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration H+ + NADPH + Butanal = NADP+ + 1-Butanol 0.0001 M NADPH CHEBI:16474 1.1.1.2;3329 wildtype II; 37.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:6753936 SabioRK AAP, ASD 0 220004012 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0017 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004013 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0002 M NADPH CHEBI:16474 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004014 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat/Km Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 786.0 M^(-1)*s^(-1) glyceraldehyde CHEBI:5445 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004015 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 1.3 s^(-1) 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004016 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.00016 M p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.2;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004017 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 5.1 s^(-1) 1.1.1.2;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004018 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0002 M NADPH CHEBI:16474 1.1.1.2;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004019 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat/Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 32025.0 M^(-1)*s^(-1) p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.2;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004020 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.336 M malonic acid CHEBI:30794 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004021 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.004 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004022 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.085 M succinic acid CHEBI:15741 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004023 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00211 M glutaric acid CHEBI:17859 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004024 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00189 M adipic acid CHEBI:30832 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004025 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00161 M pimelic acid CHEBI:30531 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004026 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00173 M suberic acid CHEBI:9300 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004027 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 1.06e-05 M Dimethylsuccinic acid CHEBI:NONE_161843 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004028 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.000138 M Tetramethyleneglutaric acid CHEBI:NONE_161844 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004029 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.003 M glyceraldehyde CHEBI:5445 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004030 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 6.2e-05 M AL1576 CHEBI:NONE_161845 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004031 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00072 M tolrestat CHEBI:48549 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004032 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0046 M Ponalrestat CHEBI:NONE_161846 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004033 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0054 M sorbinil CHEBI:102029 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004034 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0145 M FK366 CHEBI:NONE_161847 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004035 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.027 M Zopolrestat CHEBI:NONE_161677 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004036 curatus P14550 10327 AKR1A1 Homo sapiens 9606 IC50 Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.148 M Alrestatin CHEBI:NONE_161848 1.1.1.2;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004037 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Kd Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 7.1e-08 M NADPH CHEBI:16474 1.1.1.2;6749 wildtype; 20.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004038 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Kd Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 3.6e-07 M NADP+ CHEBI:NONE_161814 1.1.1.2;6749 wildtype; 20.0; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:8916913 SabioRK AAP, ASD 0 220004039 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat/Km NADPH + H+ + 2-Nitrobenzaldehyde = NADP+ + 2-Nitrobenzyl alcohol 833.333333 M^(-1)*s^(-1) 2-nitrobenzaldehyde CHEBI:66927 1.1.1.2;8071 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004040 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km NADPH + H+ + 2-Nitrobenzaldehyde = NADP+ + 2-Nitrobenzyl alcohol 5.4e-05 M 2-nitrobenzaldehyde CHEBI:66927 1.1.1.2;8071 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:4.0E-6|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004041 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration NADPH + H+ + 2-Nitrobenzaldehyde = NADP+ + 2-Nitrobenzyl alcohol 0.0002 M NADPH CHEBI:16474 1.1.1.2;8071 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004042 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat NADPH + H+ + 2-Nitrobenzaldehyde = NADP+ + 2-Nitrobenzyl alcohol 0.05 s^(-1) 1.1.1.2;8071 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:0.00166667|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004043 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 0.0002 M NADPH CHEBI:16474 1.1.1.2;6755 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004044 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 1.68333333 s^(-1) 1.1.1.2;6755 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:0.0166667|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004045 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 0.001008 M m-Nitrobenzaldehyde CHEBI:NONE_161831 1.1.1.2;6755 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:6.0E-6|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004046 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat/Km NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 1666.66667 M^(-1)*s^(-1) m-Nitrobenzaldehyde CHEBI:NONE_161831 1.1.1.2;6755 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004047 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat/Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 36666.6667 M^(-1)*s^(-1) 4-nitrobenzaldehyde CHEBI:66926 1.1.1.2;6758 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004048 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.000191 M 4-nitrobenzaldehyde CHEBI:66926 1.1.1.2;6758 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:1.9E-5|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004049 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 6.95 s^(-1) 1.1.1.2;6758 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:0.0833333|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004050 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0002 M NADPH CHEBI:16474 1.1.1.2;6758 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004051 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 6.18333333 s^(-1) 1.1.1.2;6776 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:0.2|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004052 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat/Km H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 10000.0 M^(-1)*s^(-1) Pyridine-3-aldehyde CHEBI:NONE_161830 1.1.1.2;6776 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004053 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 0.0002 M NADPH CHEBI:16474 1.1.1.2;6776 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004054 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 0.000597 M Pyridine-3-aldehyde CHEBI:NONE_161830 1.1.1.2;6776 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:1.5E-5|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004055 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat H+ + NADPH + Pyridine-4-aldehyde = NADP+ + 4-Pyridinemethanol 6.2 s^(-1) 1.1.1.2;10861 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:0.333333|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004056 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat/Km H+ + NADPH + Pyridine-4-aldehyde = NADP+ + 4-Pyridinemethanol 8333.33333 M^(-1)*s^(-1) Pyridine-4-aldehyde CHEBI:NONE_161837 1.1.1.2;10861 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004057 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km H+ + NADPH + Pyridine-4-aldehyde = NADP+ + 4-Pyridinemethanol 0.000794 M Pyridine-4-aldehyde CHEBI:NONE_161837 1.1.1.2;10861 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:6.9E-5|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004058 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration H+ + NADPH + Pyridine-4-aldehyde = NADP+ + 4-Pyridinemethanol 0.0002 M NADPH CHEBI:16474 1.1.1.2;10861 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004059 curatus P14550 10327 AKR1A1 Homo sapiens 9606 Km 9,10-Phenanthroquinone + H+ + NADPH = NADP+ + Phenanthrene-9,10-diol 0.000152 M 9,10-phenanthroquinone CHEBI:37454 1.1.1.2;7755 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:9.0E-6|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004060 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat/Km 9,10-Phenanthroquinone + H+ + NADPH = NADP+ + Phenanthrene-9,10-diol 5000.0 M^(-1)*s^(-1) 9,10-phenanthroquinone CHEBI:37454 1.1.1.2;7755 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004061 curatus P14550 10327 AKR1A1 Homo sapiens 9606 kcat 9,10-Phenanthroquinone + H+ + NADPH = NADP+ + Phenanthrene-9,10-diol 0.833333333 s^(-1) 1.1.1.2;7755 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:0.0666667|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004062 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration 9,10-Phenanthroquinone + H+ + NADPH = NADP+ + Phenanthrene-9,10-diol 0.0002 M NADPH CHEBI:16474 1.1.1.2;7755 wildtype AKR1A1, his-tagged; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10510318 SabioRK AAP, ASD 0 220004063 curatus P11712 1559 CYP2C9 Homo sapiens 9606 kcat/Km O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 50000.0 M^(-1)*s^(-1) 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide CHEBI:NONE_161839 1.14.13;7240 wildtype 2C9; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK AAP, DGA, ASD 0 220004064 curatus P11712 1559 CYP2C9 Homo sapiens 9606 kcat O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 0.583333333 s^(-1) 1.14.13;7240 wildtype 2C9; 28.0; 7.4|std.dev:0.0833333|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK AAP, DGA, ASD 0 220004065 curatus P11712 1559 CYP2C9 Homo sapiens 9606 Km O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 1.2e-05 M 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide CHEBI:NONE_161839 1.14.13;7240 wildtype 2C9; 28.0; 7.4|std.dev:1.0E-6|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK AAP, DGA, ASD 0 220004066 curatus P10632 1558 CYP2C8 Homo sapiens 9606 kcat O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 0.0666666667 s^(-1) 1.14.14.1;7240 wildtype 2C8; 28.0; 7.4|std.dev:0.0166667|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK AAP, DGA, ASD 0 220004067 curatus P10632 1558 CYP2C8 Homo sapiens 9606 Km O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 4e-05 M 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide CHEBI:NONE_161839 1.14.14.1;7240 wildtype 2C8; 28.0; 7.4|std.dev:5.0E-6|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK AAP, DGA, ASD 0 220004068 curatus P10632 1558 CYP2C8 Homo sapiens 9606 kcat/Km O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 1666.66667 M^(-1)*s^(-1) 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide CHEBI:NONE_161839 1.14.14.1;7240 wildtype 2C8; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK AAP, DGA, ASD 0 220004069 curatus P05181 1571 CYP2E1 Homo sapiens 9606 kcat O2 + H+ + NADPH + Chlorzoxazone = H2O + 6-Hydroxy-chlorzoxazone + NADP+ 0.3145 s^(-1) 1.14.13;11159 wildtype isoform CYP2E1; 37.0; 7.4|std.dev:0.00216667|Tissue:liver|Cellular Location:microsome Y Y PubMed:16168565 SabioRK AAP, DGA, ASD 0 220004096 curatus P05181 1571 CYP2E1 Homo sapiens 9606 Km O2 + H+ + NADPH + Chlorzoxazone = H2O + 6-Hydroxy-chlorzoxazone + NADP+ 0.00107 M chlorzoxazone CHEBI:3655 1.14.13;11159 wildtype isoform CYP2E1; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:16168565 SabioRK AAP, DGA, ASD 0 220004097 curatus P05181 1571 CYP2E1 Homo sapiens 9606 kcat/Km O2 + H+ + NADPH + Chlorzoxazone = H2O + 6-Hydroxy-chlorzoxazone + NADP+ 294.0 M^(-1)*s^(-1) chlorzoxazone CHEBI:3655 1.14.13;11159 wildtype isoform CYP2E1; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:16168565 SabioRK AAP, DGA, ASD 0 220004098 curatus P05181 1571 CYP2E1 Homo sapiens 9606 concentration O2 + H+ + NADPH + Chlorzoxazone = H2O + 6-Hydroxy-chlorzoxazone + NADP+ 0.0005 M NADPH CHEBI:16474 1.14.13;11159 wildtype isoform CYP2E1; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:16168565 SabioRK AAP, DGA, ASD 0 220004099 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0005 mg/ml Enzyme CHEBI:NONE_161823 4.4.1.20;8569 mutant R51H; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant; Original range: 1.5E-5-5.0E-4 AAP, DGA, ASD 0 220004130 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 1.5e-05 mg/ml Enzyme CHEBI:NONE_161823 4.4.1.20;8569 mutant Y93F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant; Original range: 1.5E-5-5.0E-4 AAP, DGA, ASD 0 220004131 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0005 mg/ml Enzyme CHEBI:NONE_161823 4.4.1.20;8569 mutant Y93F; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant; Original range: 1.5E-5-5.0E-4 AAP, DGA, ASD 0 220004132 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 1.5e-05 mg/ml Enzyme CHEBI:NONE_161823 4.4.1.20;8569 mutant C82V; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant; Original range: 1.5E-5-5.0E-4 AAP, DGA, ASD 0 220004133 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0005 mg/ml Enzyme CHEBI:NONE_161823 4.4.1.20;8569 mutant C82V; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Mutant; Original range: 1.5E-5-5.0E-4 AAP, DGA, ASD 0 220004134 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 6e-06 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Original range: 6.0E-6-2.0E-5 AAP, DGA, ASD 0 220004135 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 2e-05 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Original range: 6.0E-6-2.0E-5 AAP, DGA, ASD 0 220004136 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0005 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Original range: 5.0E-4-0.002 AAP, DGA, ASD 0 220004137 curatus Q16873 4056 LTC4S Homo sapiens 9606 Km Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.002 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Original range: 5.0E-4-0.002 AAP, DGA, ASD 0 220004138 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 1.5e-05 mg/ml Enzyme CHEBI:NONE_161823 4.4.1.20;8569 wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Original range: 1.5E-5-5.0E-4 AAP, DGA, ASD 0 220004139 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.0005 mg/ml Enzyme CHEBI:NONE_161823 4.4.1.20;8569 wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Original range: 1.5E-5-5.0E-4 AAP, DGA, ASD 0 220004140 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.02 M leukotriene A4 CHEBI:15651 4.4.1.20;8569 wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Original range: 0.0-0.02 AAP, DGA, ASD 0 220004141 curatus Q16873 4056 LTC4S Homo sapiens 9606 concentration Leukotriene A4 + Reduced glutathione = Leukotriene C4 0.01 M Reduced glutathione CHEBI:NONE_161821 4.4.1.20;8569 wildtype; 22.0; 7.6|std.dev:-|Tissue:-|Cellular Location:microsome Y Y PubMed:9153254 SabioRK Original range: 0.0-0.01 AAP, DGA, ASD 0 220004142 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 1.5e-06 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 mutant D269A; 37.0; 7.5|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:unknown Y Y PubMed:8486631 SabioRK Mutant; Original range: 0.0-1.5E-6 AAP 0 220004143 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 1.0 mg/ml Enzyme CHEBI:NONE_161823 1.14.13.30;3615 mutant D269A; 37.0; 7.5|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:unknown Y Y PubMed:8486631 SabioRK Mutant; Original range: 1.0-2.5 AAP 0 220004144 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 2.5 mg/ml Enzyme CHEBI:NONE_161823 1.14.13.30;3615 mutant D269A; 37.0; 7.5|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:unknown Y Y PubMed:8486631 SabioRK Mutant; Original range: 1.0-2.5 AAP 0 220004145 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration 20-CHO-Leukotriene B4 + O2 + H+ + NADPH = 20-COOH-Leukotriene B4 + H2O + NADP+ 4.8e-06 M 20-CHO-Leukotriene B4 CHEBI:NONE_161822 1.14.13.30;9867 wildtype isoenzyme CYP4F3; 37.0; 8.0|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:microsome Y Y PubMed:2549038 SabioRK Original range: 0.0-4.8E-6 AAP 0 220004146 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 5e-08 M NADPH CHEBI:16474 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:|Tissue:polymorphonuclear leukocyte|Cellular Location:cytoplasm Y Y PubMed:2986111 SabioRK Original range: 5.0E-8-1.0E-4 AAP 0 220004147 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.0001 M NADPH CHEBI:16474 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:|Tissue:polymorphonuclear leukocyte|Cellular Location:cytoplasm Y Y PubMed:2986111 SabioRK Original range: 5.0E-8-1.0E-4 AAP 0 220004148 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 1.5e-06 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:|Tissue:polymorphonuclear leukocyte|Cellular Location:cytoplasm Y Y PubMed:2986111 SabioRK Original range: 1.5E-6-1.0E-4 AAP 0 220004149 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.0001 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:|Tissue:polymorphonuclear leukocyte|Cellular Location:cytoplasm Y Y PubMed:2986111 SabioRK Original range: 1.5E-6-1.0E-4 AAP 0 220004150 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 5e-08 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:|Tissue:polymorphonuclear leukocyte|Cellular Location:cytoplasm Y Y PubMed:2986111 SabioRK Original range: 5.0E-8-5.0E-6 AAP 0 220004151 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 5e-06 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:|Tissue:polymorphonuclear leukocyte|Cellular Location:cytoplasm Y Y PubMed:2986111 SabioRK Original range: 5.0E-8-5.0E-6 AAP 0 220004152 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 3.03e-07 M NADPH CHEBI:16474 1.14.13.30;3615 wildtype; 37.0; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK Original range: 3.03E-7-1.0E-5 AAP 0 220004153 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 1e-05 M NADPH CHEBI:16474 1.14.13.30;3615 wildtype; 37.0; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK Original range: 3.03E-7-1.0E-5 AAP 0 220004154 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 1.1e-07 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype; 37.0; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK Original range: 1.1E-7-2.0E-6 AAP 0 220004155 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 2e-06 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype; 37.0; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK Original range: 1.1E-7-2.0E-6 AAP 0 220004156 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 1.6e-07 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype; -; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK Original range: 1.6E-7-4.0E-6 AAP 0 220004157 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 4e-06 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype; -; 7.4|std.dev:-|Tissue:neutrophil|Cellular Location:microsome Y Y PubMed:3127205 SabioRK Original range: 1.6E-7-4.0E-6 AAP 0 220004158 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 kcat O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.013 mol*s^(-1)*mol^(-1) 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:unknown Y Y PubMed:8486631 SabioRK Original range: 0.013-0.0233333333 AAP 0 220004159 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 kcat O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 0.0233333333 mol*s^(-1)*mol^(-1) 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:unknown Y Y PubMed:8486631 SabioRK Original range: 0.013-0.0233333333 AAP 0 220004160 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 1.5e-06 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:unknown Y Y PubMed:8486631 SabioRK Original range: 0.0-1.5E-6 AAP 0 220004161 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 1.0 mg/ml Enzyme CHEBI:NONE_161823 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:unknown Y Y PubMed:8486631 SabioRK Original range: 1.0-2.5 AAP 0 220004162 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 2.5 mg/ml Enzyme CHEBI:NONE_161823 1.14.13.30;3615 wildtype; 37.0; 7.5|std.dev:-|Tissue:polymorphonuclear leukocyte|Cellular Location:unknown Y Y PubMed:8486631 SabioRK Original range: 1.0-2.5 AAP 0 220004163 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 3e-07 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype isoenzyme CYP4F3A; 37.0; 8.0|std.dev:-|Tissue:neutrophil|Cellular Location:unknown Y Y PubMed:10409674 SabioRK Original range: 3.0E-7-8.0E-6 AAP 0 220004164 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 8e-06 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype isoenzyme CYP4F3A; 37.0; 8.0|std.dev:-|Tissue:neutrophil|Cellular Location:unknown Y Y PubMed:10409674 SabioRK Original range: 3.0E-7-8.0E-6 AAP 0 220004165 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 1.4e-06 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype isoenzyme CYP4F3B; 37.0; 8.0|std.dev:-|Tissue:fetal liver|Cellular Location:microsome Y Y PubMed:10409674 SabioRK Original range: 1.4E-6-8.0E-5 AAP 0 220004166 curatus Q08477 4051 CYP4F3 Homo sapiens 9606 concentration O2 + H+ + NADPH + Leukotriene B4 = 20-OH-Leukotriene B4 + H2O + NADP+ 8e-05 M leukotriene B4 CHEBI:15647 1.14.13.30;3615 wildtype isoenzyme CYP4F3B; 37.0; 8.0|std.dev:-|Tissue:fetal liver|Cellular Location:microsome Y Y PubMed:10409674 SabioRK Original range: 1.4E-6-8.0E-5 AAP 0 220004167 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 3e-06 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1;7911 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.0E-6-5.0E-5 AAP, ASD 0 220004168 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 5e-05 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1;7911 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.0E-6-5.0E-5 AAP, ASD 0 220004169 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 3.75e-06 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1;2409 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.75E-6-7.5E-5 AAP, ASD 0 220004170 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 7.5e-05 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1;2409 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.75E-6-7.5E-5 AAP, ASD 0 220004171 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 3e-06 M testosterone CHEBI:17347 1.1.1;1917 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.0E-6-5.0E-5 AAP, ASD 0 220004172 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 5e-05 M testosterone CHEBI:17347 1.1.1;1917 wildtype AKR1C1; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.0E-6-5.0E-5 AAP, ASD 0 220004173 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration NADPH + H+ + 5alpha-Androstan-17beta-ol-3-one = 5alpha-Androstan-3beta,17beta-diol + NADP+ 1.2e-05 M NADPH CHEBI:16474 1.1.1;8080 wildtype AKR1C1; -; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK Original range: 1.2E-5-2.5E-5 AAP, ASD 0 220004174 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration NADPH + H+ + 5alpha-Androstan-17beta-ol-3-one = 5alpha-Androstan-3beta,17beta-diol + NADP+ 2.5e-05 M NADPH CHEBI:16474 1.1.1;8080 wildtype AKR1C1; -; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK Original range: 1.2E-5-2.5E-5 AAP, ASD 0 220004175 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration NADPH + H+ + 5alpha-Androstan-17beta-ol-3-one = 5alpha-Androstan-3beta,17beta-diol + NADP+ 1e-07 M 5alpha-Dihydrotestosterone CHEBI:NONE_161826 1.1.1;8080 wildtype AKR1C1; -; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK Original range: 1.0E-7-5.0E-5 AAP, ASD 0 220004176 curatus Q04828 1645 AKR1C1 Homo sapiens 9606 concentration NADPH + H+ + 5alpha-Androstan-17beta-ol-3-one = 5alpha-Androstan-3beta,17beta-diol + NADP+ 5e-05 M 5alpha-Dihydrotestosterone CHEBI:NONE_161826 1.1.1;8080 wildtype AKR1C1; -; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK Original range: 1.0E-7-5.0E-5 AAP, ASD 0 220004177 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.0002 M (s)-indan-1-ol CHEBI:NONE_161458 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK Original range: 2.0E-4-0.001 AAP, ASD 0 220004178 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 0.001 M (s)-indan-1-ol CHEBI:NONE_161458 1.1.1.213;7882 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK Original range: 2.0E-4-0.001 AAP, ASD 0 220004179 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.0002 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1.213;2409 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK Original range: 2.0E-4-0.001 AAP, ASD 0 220004180 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 0.001 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1.213;2409 wildtype isoenzyme dihydrodiol dehydrogenase 2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:1554355 SabioRK Original range: 2.0E-4-0.001 AAP, ASD 0 220004181 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + (S)-Indan-1-ol = H+ + Indanone + NADPH 1.0 M (s)-indan-1-ol CHEBI:NONE_161458 1.3.1.20;7882 wildtype DD2; 25.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:9716498 SabioRK Original range: 0.0-1.0 AAP, ASD 0 220004182 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 3e-06 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.0E-6-5.0E-5 AAP, ASD 0 220004183 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 5e-05 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.0E-6-5.0E-5 AAP, ASD 0 220004184 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 2.5e-06 M 5alpha-androstane-3,17-dione CHEBI:15994 1.1.1.213;2409 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 2.5E-6-5.0E-5 AAP, ASD 0 220004185 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 5e-05 M 5alpha-androstane-3,17-dione CHEBI:15994 1.1.1.213;2409 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 2.5E-6-5.0E-5 AAP, ASD 0 220004186 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 3.75e-06 M 5alpha-androstane-3alpha,17beta-diol CHEBI:36713 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.75E-6-7.5E-5 AAP, ASD 0 220004187 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 7.5e-05 M 5alpha-androstane-3alpha,17beta-diol CHEBI:36713 1.1.1.213;7911 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.75E-6-7.5E-5 AAP, ASD 0 220004188 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 3.75e-06 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1.213;2409 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.75E-6-7.5E-5 AAP, ASD 0 220004189 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 7.5e-05 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1.213;2409 wildtype AKR1C2; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.75E-6-7.5E-5 AAP, ASD 0 220004190 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 1.2e-05 M NADPH CHEBI:16474 1.1.1;7911 wildtype AKR1C2; -; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK Original range: 1.2E-5-2.5E-5 AAP, ASD 0 220004191 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 2.5e-05 M NADPH CHEBI:16474 1.1.1;7911 wildtype AKR1C2; -; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK Original range: 1.2E-5-2.5E-5 AAP, ASD 0 220004192 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 1e-07 M 5alpha-Dihydrotestosterone CHEBI:NONE_161826 1.1.1;7911 wildtype AKR1C2; -; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK Original range: 1.0E-7-5.0E-5 AAP, ASD 0 220004193 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 5e-05 M 5alpha-Dihydrotestosterone CHEBI:NONE_161826 1.1.1;7911 wildtype AKR1C2; -; 7.0|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:19218247 SabioRK Original range: 1.0E-7-5.0E-5 AAP, ASD 0 220004194 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NAD+ + 5alpha-Androstane-3alpha-ol-17-one = NADH + 5alpha-Androstane-3,17-dione + H+ 0.2 M androsterone CHEBI:16032 1.1.1.357;2408 wildtype; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:22437839 SabioRK Original range: 0.2-60.0 AAP, ASD 0 220004195 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NAD+ + 5alpha-Androstane-3alpha-ol-17-one = NADH + 5alpha-Androstane-3,17-dione + H+ 60.0 M androsterone CHEBI:16032 1.1.1.357;2408 wildtype; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:22437839 SabioRK Original range: 0.2-60.0 AAP, ASD 0 220004196 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one = H+ + NADH + 5beta-Androstane-3,17-dione 0.2 M 3alpha-hydroxy-5beta-androstan-17-one CHEBI:28195 1.1.1.357;4008 wildtype; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:22437839 SabioRK Original range: 0.2-60.0 AAP, ASD 0 220004197 curatus P52895 1646 AKR1C2 Homo sapiens 9606 concentration NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one = H+ + NADH + 5beta-Androstane-3,17-dione 60.0 M 3alpha-hydroxy-5beta-androstan-17-one CHEBI:28195 1.1.1.357;4008 wildtype; 37.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:22437839 SabioRK Original range: 0.2-60.0 AAP, ASD 0 220004198 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 1.0 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.357;7911 wildtype 3alpha HSD type II; 37.0; 7.4|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:7650035 SabioRK Original range: 1.0-20.0 AAP, ASD 0 220004201 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 20.0 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.357;7911 wildtype 3alpha HSD type II; 37.0; 7.4|std.dev:-|Tissue:-|Cellular Location:cytosol Y Y PubMed:7650035 SabioRK Original range: 1.0-20.0 AAP, ASD 0 220004202 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 3.5e-06 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK Original range: 3.5E-6-5.25E-5 AAP, ASD 0 220004203 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 5.25e-05 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK Original range: 3.5E-6-5.25E-5 AAP, ASD 0 220004204 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 1.85e-06 M 5alpha-androstane-3,17-dione CHEBI:15994 1.1.1.213;2409 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK Original range: 1.85E-6-5.625E-5 AAP, ASD 0 220004205 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 5.625e-05 M 5alpha-androstane-3,17-dione CHEBI:15994 1.1.1.213;2409 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK Original range: 1.85E-6-5.625E-5 AAP, ASD 0 220004206 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration 9,10-Phenanthroquinone + H+ + NADPH = NADP+ + Phenanthrene-9,10-diol 5e-06 M 9,10-phenanthroquinone CHEBI:37454 1.1.1.213;7755 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK Original range: 5.0E-6-2.0E-4 AAP, ASD 0 220004207 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration 9,10-Phenanthroquinone + H+ + NADPH = NADP+ + Phenanthrene-9,10-diol 0.0002 M 9,10-phenanthroquinone CHEBI:37454 1.1.1.213;7755 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK Original range: 5.0E-6-2.0E-4 AAP, ASD 0 220004208 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 5e-05 M p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.213;6758 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK Original range: 5.0E-5-0.0015 AAP, ASD 0 220004209 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0015 M p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.213;6758 wildtype 3alpha-HSD Type 2; 25.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK Original range: 5.0E-5-0.0015 AAP, ASD 0 220004210 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 3.8e-06 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK Original range: 3.8E-6-3.82E-5 AAP, ASD 0 220004211 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 3.82e-05 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK Original range: 3.8E-6-3.82E-5 AAP, ASD 0 220004212 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 2.5e-06 M testosterone CHEBI:17347 1.1.1.213;1917 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK Original range: 2.5E-6-5.0E-5 AAP, ASD 0 220004213 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 5e-05 M testosterone CHEBI:17347 1.1.1.213;1917 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK Original range: 2.5E-6-5.0E-5 AAP, ASD 0 220004214 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 3.75e-06 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1.213;2409 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK Original range: 3.75E-6-7.5E-5 AAP, ASD 0 220004215 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + 5alpha-Androstane-3alpha-ol-17-one = NADPH + H+ + 5alpha-Androstane-3,17-dione 7.5e-05 M 5alpha-Androstane-3alpha-ol-17-one CHEBI:NONE_161825 1.1.1.213;2409 wildtype 3alpha-HSD Type 2; 37.0; 7.0|std.dev:-|Tissue:prostate|Cellular Location:unknown Y Y PubMed:9415401 SabioRK Original range: 3.75E-6-7.5E-5 AAP, ASD 0 220004216 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 3e-06 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.0E-6-5.0E-5 AAP, ASD 0 220004217 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 5e-05 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.0E-6-5.0E-5 AAP, ASD 0 220004218 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 3.75e-06 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.75E-6-7.5E-5 AAP, ASD 0 220004219 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration H+ + NADPH + 5alpha-Androstan-17beta-ol-3-one = NADP+ + 5alpha-Androstane-3alpha,17beta-diol 7.5e-05 M 5alpha-Androstan-17beta-ol-3-one CHEBI:NONE_161824 1.1.1.213;7911 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.75E-6-7.5E-5 AAP, ASD 0 220004220 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 3e-06 M testosterone CHEBI:17347 1.1.1.239;1917 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.0E-6-5.0E-5 AAP, ASD 0 220004221 curatus P42330 8644 AKR1C3 Homo sapiens 9606 concentration NADP+ + Testosterone = H+ + NADPH + Androst-4-ene-3,17-dione 5e-05 M testosterone CHEBI:17347 1.1.1.239;1917 wildtype AKR1C3; 25.0; 7.0|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:10998348 SabioRK Original range: 3.0E-6-5.0E-5 AAP, ASD 0 220004222 curatus P33261 1557 CYP2C19 Homo sapiens 9606 concentration O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 2e-08 M Enzyme CHEBI:NONE_161823 1.14.13;7240 wildtype 2C19; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK Original range: 2.0E-8-1.0E-7 AAP, DGA, ASD 0 220004223 curatus P33261 1557 CYP2C19 Homo sapiens 9606 concentration O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 1e-07 M Enzyme CHEBI:NONE_161823 1.14.13;7240 wildtype 2C19; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK Original range: 2.0E-8-1.0E-7 AAP, DGA, ASD 0 220004224 curatus P33261 1557 CYP2C19 Homo sapiens 9606 concentration O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 0.0001 M 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide CHEBI:NONE_161839 1.14.13;7240 wildtype 2C19; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK Original range: 0.0-1.0E-4 AAP, DGA, ASD 0 220004225 curatus P33260 1562 CYP2C18 Homo sapiens 9606 concentration O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 0.0001 M 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide CHEBI:NONE_161839 1.14.14.1;7240 wildtype 2C18; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK Original range: 0.0-1.0E-4 AAP, ASD 0 220004226 curatus P33260 1562 CYP2C18 Homo sapiens 9606 concentration O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 2e-08 M Enzyme CHEBI:NONE_161823 1.14.14.1;7240 wildtype 2C18; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK Original range: 2.0E-8-1.0E-7 AAP, ASD 0 220004227 curatus P33260 1562 CYP2C18 Homo sapiens 9606 concentration O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 1e-07 M Enzyme CHEBI:NONE_161823 1.14.14.1;7240 wildtype 2C18; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK Original range: 2.0E-8-1.0E-7 AAP, ASD 0 220004228 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.001 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C226A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-0.001 AAP, ASD 0 220004229 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-2.5E-4 AAP, ASD 0 220004230 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-2.5E-4 AAP, ASD 0 220004231 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-2.5E-4 AAP, ASD 0 220004232 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.004 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C227A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-0.004 AAP, ASD 0 220004233 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.004 M menadiol CHEBI:6746 1.1.1.184;9874 mutant C227S; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-0.004 AAP, ASD 0 220004234 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 0.0025 M 4-benzoylpyridine CHEBI:NONE_148506 1.1.1.184;11767 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-0.0025 AAP, ASD 0 220004235 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 0.0025 M 4-benzoylpyridine CHEBI:NONE_148506 1.1.1.184;11767 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-0.0025 AAP, ASD 0 220004236 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 0.0025 M 4-benzoylpyridine CHEBI:NONE_148506 1.1.1.184;11767 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-0.0025 AAP, ASD 0 220004237 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.001 M daunorubicin CHEBI:41977 1.1.1.184;8084 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-0.001 AAP, ASD 0 220004238 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.001 M daunorubicin CHEBI:41977 1.1.1.184;8084 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-0.001 AAP, ASD 0 220004239 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.001 M daunorubicin CHEBI:41977 1.1.1.184;8084 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-0.001 AAP, ASD 0 220004240 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.002 M daunorubicin CHEBI:41977 1.1.1.184;8084 mutant C226A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-0.002 AAP, ASD 0 220004241 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.002 M daunorubicin CHEBI:41977 1.1.1.184;8084 mutant C227A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-0.002 AAP, ASD 0 220004242 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.002 M daunorubicin CHEBI:41977 1.1.1.184;8084 mutant C227S; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-0.002 AAP, ASD 0 220004243 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C26A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-5.0E-5 AAP, ASD 0 220004244 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C122A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-5.0E-5 AAP, ASD 0 220004245 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C150A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-5.0E-5 AAP, ASD 0 220004246 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C226A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-5.0E-5 AAP, ASD 0 220004247 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C227A; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-5.0E-5 AAP, ASD 0 220004248 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 mutant C227S; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Mutant; Original range: 0.0-5.0E-5 AAP, ASD 0 220004249 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00025 M menadiol CHEBI:6746 1.1.1.184;9874 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Original range: 0.0-2.5E-4 AAP, ASD 0 220004250 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + 4-Benzoylpyridine = NADP+ + Phenyl(pyridin-4-yl)methanol 0.0025 M 4-benzoylpyridine CHEBI:NONE_148506 1.1.1.184;11767 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Original range: 0.0-0.0025 AAP, ASD 0 220004251 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + H+ + Daunorubicin = Unknown + NADP+ 0.001 M daunorubicin CHEBI:41977 1.1.1.184;8084 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Original range: 0.0-0.001 AAP, ASD 0 220004252 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 wildtype; 25.0; 7.0|std.dev:-|Tissue:placenta|Cellular Location:cytosol Y Y PubMed:10091578 SabioRK Original range: 0.0-5.0E-5 AAP, ASD 0 220004253 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 0.00025 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;12036 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-2.5E-4 AAP, ASD 0 220004254 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 0.00025 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;12036 wildtype isoform I88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-2.5E-4 AAP, ASD 0 220004255 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 0.00025 M 5,7,2-Trihydroxyethylrutoside CHEBI:NONE_161842 1.1.1.184;12036 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-2.5E-4 AAP, ASD 0 220004256 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 0.00025 M 5,7,2-Trihydroxyethylrutoside CHEBI:NONE_161842 1.1.1.184;12036 wildtype isoform I88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-2.5E-4 AAP, ASD 0 220004257 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 0.00025 M quercetin CHEBI:16243 1.1.1.184;12036 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-2.5E-4 AAP, ASD 0 220004258 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Adriamycin = NADP+ + Doxorubicinol 0.00025 M quercetin CHEBI:16243 1.1.1.184;12036 wildtype isoform I88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-2.5E-4 AAP, ASD 0 220004259 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.00025 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-2.5E-4 AAP, ASD 0 220004260 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.00025 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;12037 wildtype isoform I88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-2.5E-4 AAP, ASD 0 220004261 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.00025 M 5,7,2-Trihydroxyethylrutoside CHEBI:NONE_161842 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-2.5E-4 AAP, ASD 0 220004262 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.00025 M 5,7,2-Trihydroxyethylrutoside CHEBI:NONE_161842 1.1.1.184;12037 wildtype isoform I88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-2.5E-4 AAP, ASD 0 220004263 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.00025 M quercetin CHEBI:16243 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-2.5E-4 AAP, ASD 0 220004264 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.00025 M quercetin CHEBI:16243 1.1.1.184;12037 wildtype isoform I88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-2.5E-4 AAP, ASD 0 220004265 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.0007 M daunorubicin CHEBI:41977 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-7.0E-4 AAP, ASD 0 220004266 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 2e-05 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 2.0E-5-1.0E-4 AAP, ASD 0 220004267 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.0001 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 2.0E-5-1.0E-4 AAP, ASD 0 220004268 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 2.5e-05 M NADPH CHEBI:16474 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 2.5E-5-3.0E-4 AAP, ASD 0 220004269 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.0003 M NADPH CHEBI:16474 1.1.1.184;12037 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 2.5E-5-3.0E-4 AAP, ASD 0 220004270 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.0003 M menadione CHEBI:28869 1.1.1.184;9874 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-3.0E-4 AAP, ASD 0 220004271 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 2e-05 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;9874 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 2.0E-5-1.0E-4 AAP, ASD 0 220004272 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.0001 M 7-Monohydroxyethylrutoside CHEBI:NONE_161841 1.1.1.184;9874 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 2.0E-5-1.0E-4 AAP, ASD 0 220004273 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 2.5e-05 M NADPH CHEBI:16474 1.1.1.184;9874 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 2.5E-5-3.0E-4 AAP, ASD 0 220004274 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.0003 M NADPH CHEBI:16474 1.1.1.184;9874 wildtype isoform V88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 2.5E-5-3.0E-4 AAP, ASD 0 220004275 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + Daunorubicin = NADP+ + 13-Dihydrodaunorubicin 0.0007 M daunorubicin CHEBI:41977 1.1.1.184;12037 wildtype isoform I88; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:18449627 SabioRK Original range: 0.0-7.0E-4 AAP, ASD 0 220004276 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + S-Nitrosoglutathione = NADP+ + GSN 1.26e-07 M Enzyme CHEBI:NONE_161823 1.1.1.184;11757 wildtype isoenzyme CBR1; 25.0; 6.8|std.dev:-|Tissue:-|Cellular Location:cytoplasm Y Y PubMed:18826943 SabioRK Original range: 1.26E-7-2.52E-7 AAP, ASD 0 220004277 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + S-Nitrosoglutathione = NADP+ + GSN 2.52e-07 M Enzyme CHEBI:NONE_161823 1.1.1.184;11757 wildtype isoenzyme CBR1; 25.0; 6.8|std.dev:-|Tissue:-|Cellular Location:cytoplasm Y Y PubMed:18826943 SabioRK Original range: 1.26E-7-2.52E-7 AAP, ASD 0 220004278 curatus P16152 873 CBR1 Homo sapiens 9606 concentration H+ + NADPH + S-Nitrosoglutathione = NADP+ + GSN 0.00015 M S-nitrosoglutathione CHEBI:50091 1.1.1.184;11757 wildtype isoenzyme CBR1; 25.0; 6.8|std.dev:-|Tissue:-|Cellular Location:cytoplasm Y Y PubMed:18826943 SabioRK Original range: 0.0-1.5E-4 AAP, ASD 0 220004279 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 0.00015 M menadione CHEBI:28869 1.1.1.184;9874 wildtype isoenzyme CBR1; 25.0; 6.8|std.dev:-|Tissue:-|Cellular Location:cytoplasm Y Y PubMed:18826943 SabioRK Original range: 0.0-1.5E-4 AAP, ASD 0 220004280 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 1.26e-07 M Enzyme CHEBI:NONE_161823 1.1.1.184;9874 wildtype isoenzyme CBR1; 25.0; 6.8|std.dev:-|Tissue:-|Cellular Location:cytoplasm Y Y PubMed:18826943 SabioRK Original range: 1.26E-7-2.52E-7 AAP, ASD 0 220004281 curatus P16152 873 CBR1 Homo sapiens 9606 concentration NADPH + Menadione + H+ = Menadiol + NADP+ 2.52e-07 M Enzyme CHEBI:NONE_161823 1.1.1.184;9874 wildtype isoenzyme CBR1; 25.0; 6.8|std.dev:-|Tissue:-|Cellular Location:cytoplasm Y Y PubMed:18826943 SabioRK Original range: 1.26E-7-2.52E-7 AAP, ASD 0 220004282 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0015 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK Original range: 0.0-0.0015 AAP, DGA, ASD 0 220004283 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.01 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 25.0; 7.0|std.dev:-|Tissue:muscle|Cellular Location:unknown Y Y PubMed:2174432 SabioRK Original range: 0.0-0.01 AAP, DGA, ASD 0 220004284 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.001 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK Original range: 0.0-0.001 AAP, DGA, ASD 0 220004285 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.00012 M NADPH CHEBI:16474 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK Original range: 0.0-1.2E-4 AAP, DGA, ASD 0 220004286 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.3 M glycerol CHEBI:17754 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK Original range: 0.0-0.3 AAP, DGA, ASD 0 220004287 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0001 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK Original range: 1.0E-4-8.0E-4 AAP, DGA, ASD 0 220004288 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0008 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:brain|Cellular Location:unknown Y Y PubMed:6773519 SabioRK Original range: 1.0E-4-8.0E-4 AAP, DGA, ASD 0 220004289 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.01 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; -; 7.0|std.dev:-|Tissue:brain|Cellular Location:cytoplasm Y Y PubMed:6815419 SabioRK Original range: 0.0-0.01 AAP, DGA, ASD 0 220004290 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration NADP+ + Xylitol = D-Xylose + H+ + NADPH 0.1 M D-xylose CHEBI:65327 1.1.1.21;1616 wildtype; -; 7.0|std.dev:-|Tissue:brain|Cellular Location:cytoplasm Y Y PubMed:6815419 SabioRK Original range: 0.0-0.1 AAP, DGA, ASD 0 220004291 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration NADPH + m-Nitrobenzaldehyde + H+ = NADP+ + m-Nitrobenzyl alcohol 0.25 M m-Nitrobenzaldehyde CHEBI:NONE_161831 1.1.1.21;6755 wildtype; 30.0; 6.2|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9565553 SabioRK Original range: 0.0-0.25 AAP, DGA, ASD 0 220004292 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration H+ + NADPH + Pyridine-3-aldehyde = NADP+ + 3-Pyridinemethanol 4.0 M Pyridine-3-aldehyde CHEBI:NONE_161830 1.1.1.21;6776 wildtype; 30.0; 6.2|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9565553 SabioRK Original range: 0.0-4.0 AAP, DGA, ASD 0 220004293 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 20.0 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 30.0; 6.2|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:9565553 SabioRK Original range: 0.0-20.0 AAP, DGA, ASD 0 220004294 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 5e-06 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 37.0; 7.4|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:18087047 SabioRK Original range: 5.0E-6-5.0E-4 AAP, DGA, ASD 0 220004295 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.0005 M glyceraldehyde CHEBI:5445 1.1.1.21;6749 wildtype; 37.0; 7.4|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:18087047 SabioRK Original range: 5.0E-6-5.0E-4 AAP, DGA, ASD 0 220004296 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.001 mg/ml Enzyme CHEBI:NONE_161823 1.1.1.21;6749 wildtype; 37.0; 7.4|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:18087047 SabioRK Original range: 0.001-0.004 AAP, DGA, ASD 0 220004297 curatus P15121 231 AKR1B1 Homo sapiens 9606 concentration Glyceraldehyde + H+ + NADPH = NADP+ + Glycerol 0.004 mg/ml Enzyme CHEBI:NONE_161823 1.1.1.21;6749 wildtype; 37.0; 7.4|std.dev:-|Tissue:-|Cellular Location:unknown Y Y PubMed:18087047 SabioRK Original range: 0.001-0.004 AAP, DGA, ASD 0 220004298 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0005 M p-Nitrobenzaldehyde CHEBI:NONE_161817 1.1.1.2;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK Original range: 0.0-5.0E-4 AAP, ASD 0 220004299 curatus P14550 10327 AKR1A1 Homo sapiens 9606 concentration NADPH + p-Nitrobenzaldehyde + H+ = NADP+ + p-Nitrobenzyl alcohol 0.0001 M NADPH CHEBI:16474 1.1.1.2;6758 wildtype; 25.0; 7.0|std.dev:-|Tissue:liver|Cellular Location:unknown Y Y PubMed:16919 SabioRK Original range: 0.0-1.0E-4 AAP, ASD 0 220004300 curatus P11712 1559 CYP2C9 Homo sapiens 9606 concentration O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 0.0001 M 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide CHEBI:NONE_161839 1.14.13;7240 wildtype 2C9; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK Original range: 0.0-1.0E-4 AAP, DGA, ASD 0 220004301 curatus P11712 1559 CYP2C9 Homo sapiens 9606 concentration O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 2e-08 M Enzyme CHEBI:NONE_161823 1.14.13;7240 wildtype 2C9; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK Original range: 2.0E-8-1.0E-7 AAP, DGA, ASD 0 220004302 curatus P11712 1559 CYP2C9 Homo sapiens 9606 concentration O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 1e-07 M Enzyme CHEBI:NONE_161823 1.14.13;7240 wildtype 2C9; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK Original range: 2.0E-8-1.0E-7 AAP, DGA, ASD 0 220004303 curatus P10632 1558 CYP2C8 Homo sapiens 9606 concentration O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 2e-08 M Enzyme CHEBI:NONE_161823 1.14.14.1;7240 wildtype 2C8; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK Original range: 2.0E-8-1.0E-7 AAP, DGA, ASD 0 220004304 curatus P10632 1558 CYP2C8 Homo sapiens 9606 concentration O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 1e-07 M Enzyme CHEBI:NONE_161823 1.14.14.1;7240 wildtype 2C8; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK Original range: 2.0E-8-1.0E-7 AAP, DGA, ASD 0 220004305 curatus P10632 1558 CYP2C8 Homo sapiens 9606 concentration O2 + NADPH + H+ + 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide = H2O + NADP+ + 4-Hydroxymethyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide 0.0001 M 4-Methyl-N-methyl-N-(2-phenyl-2H-pyrazol-3-yl)-benzene sulfonamide CHEBI:NONE_161839 1.14.14.1;7240 wildtype 2C8; 28.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:12767217 SabioRK Original range: 0.0-1.0E-4 AAP, DGA, ASD 0 220004306 curatus P05181 1571 CYP2E1 Homo sapiens 9606 concentration O2 + H+ + NADPH + Chlorzoxazone = H2O + 6-Hydroxy-chlorzoxazone + NADP+ 4e-05 M chlorzoxazone CHEBI:3655 1.14.13;11159 wildtype isoform CYP2E1; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:16168565 SabioRK Original range: 4.0E-5-0.0025 AAP, DGA, ASD 0 220004312 curatus P05181 1571 CYP2E1 Homo sapiens 9606 concentration O2 + H+ + NADPH + Chlorzoxazone = H2O + 6-Hydroxy-chlorzoxazone + NADP+ 0.0025 M chlorzoxazone CHEBI:3655 1.14.13;11159 wildtype isoform CYP2E1; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:16168565 SabioRK Original range: 4.0E-5-0.0025 AAP, DGA, ASD 0 220004313 curatus P05181 1571 CYP2E1 Homo sapiens 9606 concentration O2 + H+ + NADPH + Chlorzoxazone = H2O + 6-Hydroxy-chlorzoxazone + NADP+ 5e-08 M Enzyme CHEBI:NONE_161823 1.14.13;11159 wildtype isoform CYP2E1; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:16168565 SabioRK Original range: 5.0E-8-1.0E-7 AAP, DGA, ASD 0 220004314 curatus P05181 1571 CYP2E1 Homo sapiens 9606 concentration O2 + H+ + NADPH + Chlorzoxazone = H2O + 6-Hydroxy-chlorzoxazone + NADP+ 1e-07 M Enzyme CHEBI:NONE_161823 1.14.13;11159 wildtype isoform CYP2E1; 37.0; 7.4|std.dev:-|Tissue:liver|Cellular Location:microsome Y Y PubMed:16168565 SabioRK Original range: 5.0E-8-1.0E-7 AAP, DGA, ASD 0 220004315