Category # Category name Caption (if any)
1 Central lipid and phospholipid metabolism Thousands of genes are involved in lipid metabolism.
2 Phospholipases Proteins that liberate arachidonic acid from phospholipids.
3 Arachidonic acid remodeling Proteins that catalyze the formation of other lipids from arachidonic acid.
4 AA-CoA ligases The first step in remodeling arachidonic acid or returning it to central lipid metabolism is to add coenzyme A.
5 Extension of linoleic acid
6 Diet Neither arachidonic acid nor linoleic acid can be synthesized de novo by humans.
7 COX1 Prostaglandin G2 is formed as an intermediate during the synthesis of prostaglandin H2.
8 COX2 Prostaglandin G2 is formed as an intermediate during the synthesis of prostaglandin H2.
9 Prostacyclin synthesis
10 Prostacyclin receptor
11 Prostaglandin synthesis Synthesis of prostaglandins D2, E2, and F2alpha.
12 Prostaglandin receptors
13 Thromboxane A2 synthesis
14 Thromboxane A2 receptor
15 5-Lipoxygenase
16 5-Lipoxygenase protein-level regulation ALOX5AP is required for activation of ALOX5.
17 Glutathione peroxidases
18 Metabolism of leukotriene A4
19 Leukotriene synthesis Synthesis of leukotrienes B4, C4, D4, and F4.
20 Metabolism of leukotrienes
21 Leukotriene receptors
22 Leukotriene transporters
23 15-Lipoxygenase
24 Lipoxin metabolism
25 ALOX12B
26 12-Lipoxygenase
27 Cytochrome P450s
28 HETE-forming Cytochrome P450s
29 Epoxide-forming Cytochrome P450s
30 Epoxide hydrolase
100 Arachidonic acid
101 Non-selective COX inhibitors
102 COX2-specific inhibitors
103 Prostaglandin H2 Prostaglandin G2 is formed as an intermediate during the synthesis of prostaglandin H2.
104 Prostacyclin
105 Prostacyclin metabolites
106 Prostaglandins
107 Prostaglandin metabolites
108 Thromboxane A2
109 Thromboxane metabolites
110 5(S)-HpETE 5(S)-HpETE is formed as an intermediate during the synthesis of leukotriene A4.
111 5-HETEs
112 Leukotriene A4
113 Leukotriene A4 metabolites Includes both direct and downstream metabolites of LTA4.
114 Leukotrienes
115 Leukotriene metabolites Includes both direct and downstream metabolites of LTB4, LTC4, LTD4, and LTE4.
116 15S-HpETE
117 15S-HETE
118 Lipoxins
119 Lipoxin metabolites
120 12(R)-HpETE
121 12(S)-HpETE
122 12(S)-HETE
123 Hepoxilins and Trioxilins
124 Epoxides (EETs)
125 DHETs
126 HETEs
127 Other CyP450 metabolites