Category # Category name Caption (if any) 1 Central lipid and phospholipid metabolism Thousands of genes are involved in lipid metabolism. 2 Phospholipases Proteins that liberate arachidonic acid from phospholipids. 3 Arachidonic acid remodeling Proteins that catalyze the formation of other lipids from arachidonic acid. 4 AA-CoA ligases The first step in remodeling arachidonic acid or returning it to central lipid metabolism is to add coenzyme A. 5 Extension of linoleic acid 6 Diet Neither arachidonic acid nor linoleic acid can be synthesized de novo by humans. 7 COX1 Prostaglandin G2 is formed as an intermediate during the synthesis of prostaglandin H2. 8 COX2 Prostaglandin G2 is formed as an intermediate during the synthesis of prostaglandin H2. 9 Prostacyclin synthesis 10 Prostacyclin receptor 11 Prostaglandin synthesis Synthesis of prostaglandins D2, E2, and F2alpha. 12 Prostaglandin receptors 13 Thromboxane A2 synthesis 14 Thromboxane A2 receptor 15 5-Lipoxygenase 16 5-Lipoxygenase protein-level regulation ALOX5AP is required for activation of ALOX5. 17 Glutathione peroxidases 18 Metabolism of leukotriene A4 19 Leukotriene synthesis Synthesis of leukotrienes B4, C4, D4, and F4. 20 Metabolism of leukotrienes 21 Leukotriene receptors 22 Leukotriene transporters 23 15-Lipoxygenase 24 Lipoxin metabolism 25 ALOX12B 26 12-Lipoxygenase 27 Cytochrome P450s 28 HETE-forming Cytochrome P450s 29 Epoxide-forming Cytochrome P450s 30 Epoxide hydrolase 100 Arachidonic acid 101 Non-selective COX inhibitors 102 COX2-specific inhibitors 103 Prostaglandin H2 Prostaglandin G2 is formed as an intermediate during the synthesis of prostaglandin H2. 104 Prostacyclin 105 Prostacyclin metabolites 106 Prostaglandins 107 Prostaglandin metabolites 108 Thromboxane A2 109 Thromboxane metabolites 110 5(S)-HpETE 5(S)-HpETE is formed as an intermediate during the synthesis of leukotriene A4. 111 5-HETEs 112 Leukotriene A4 113 Leukotriene A4 metabolites Includes both direct and downstream metabolites of LTA4. 114 Leukotrienes 115 Leukotriene metabolites Includes both direct and downstream metabolites of LTB4, LTC4, LTD4, and LTE4. 116 15S-HpETE 117 15S-HETE 118 Lipoxins 119 Lipoxin metabolites 120 12(R)-HpETE 121 12(S)-HpETE 122 12(S)-HETE 123 Hepoxilins and Trioxilins 124 Epoxides (EETs) 125 DHETs 126 HETEs 127 Other CyP450 metabolites