Curator Name UniProt ID NCBI Gene ID Gene Name Species Name Taxonomy ID Data Type Data Value GO Term GO ID Uberon Term Uberon ID BRENDA Tissue Ontology Term BRENDA Tissue Ontology ID Anatomy Ontology Term Anatomy Ontology ID Phenotype Ontology Term Phenotype Ontology ID Developmental Stage Term (BRENDA) Developmental Stage ID (BRENDA) Cell Type Ontology Term (CTO or CL) Cell Type Ontology ID (CTO or CL) Cell Line Ontology Term (CLO) Cell Line Ontology ID (CLO) PATO Qualifier PATO ID OMIM ID Human Disease Ontology Term Human Disease Ontology ID SNOMED Term SNOMED ID ChEBI Chemical Term ChEBI Chemical ID Secondary Source IDs Secondary Source Notes Reviewed (Y/N) Use (Y/N) Evidence Code Primary Source Secondary Source PENTACON Notes Gene Set Secondary Source Version Date Secondary Source Version PENTACON Annotation No Jenn P50393 24653 Pla2g4a Rattus norvegicus 10116 Comment/tissue specificity In untreated rat glomerular epithelial cells, cPLA2 was found in both cytosolic and microsomal fractions glomerular epithelium BTO:0001515 kidney glomerular epithelial cell CL:1000510 Y Y ECO:0000006 PubMed: 14644750 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005469 Jenn P50393 24653 Pla2g4a Rattus norvegicus 10116 Comment/tissue specificity In untreated rat glomerular epithelial cells, cPLA2 was found in both cytosolic and microsomal fractions glomerular epithelium UBERON:0004188 kidney glomerular epithelial cell CL:1000510 Y Y ECO:0000006 PubMed: 14644750 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005470 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Pretreatment of the rats in vivo with a low-salt diet, with the ACE inhibitor ramipril (10 mg/kg per d), or with a combination of both for 1 wk led to, respectively, 60%, 80%, and 230% increases of renocortical COX-2 mRNA levels renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:11316844 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; expression is upregulated in rats on a low-salt diet; Sprague-Dawley strain AAP 4/21/2014 3 3300005487 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Pretreatment of the rats in vivo with a low-salt diet, with the ACE inhibitor ramipril (10 mg/kg per d), or with a combination of both for 1 wk led to, respectively, 60%, 80%, and 230% increases of renocortical COX-2 mRNA levels cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:11316844 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; expression is upregulated in rats on a low-salt diet; Sprague-Dawley strain AAP 4/21/2014 3 3300005488 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity we found that in microdissected afferent arterioles with attached glomeruli, the COX-2 gene transcript was expressed basally and increased after pretreatment with low salt + ramipril renal glomerulus BTO:0000530 Y Y ECO:0000006 PubMed:11316844 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; expression is upregulated in rats on a low-salt diet; Sprague-Dawley strain AAP 4/21/2014 3 3300005491 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity we found that in microdissected afferent arterioles with attached glomeruli, the COX-2 gene transcript was expressed basally and increased after pretreatment with low salt + ramipril renal glomerulus UBERON:0000074 Y Y ECO:0000006 PubMed:11316844 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; expression is upregulated in rats on a low-salt diet; Sprague-Dawley strain AAP 4/21/2014 3 3300005492 Jenn P50393 24653 Pla2g4a Rattus norvegicus 10116 Comment/tissue specificity Rat mesangial cell cultures were derived from 6-week-old Sprague Dawley rats and examined for endogenous cPLA2 expression mesangium BTO:0002494 mesangial cell CL:0000650 Y Y ECO:0000006 PubMed:11416127 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005495 Jenn P50393 24653 Pla2g4a Rattus norvegicus 10116 Comment/tissue specificity Rat mesangial cell cultures were derived from 6-week-old Sprague Dawley rats and examined for endogenous cPLA2 expression mesangium UBERON:0002319 mesangial cell CL:0000650 Y Y ECO:0000006 PubMed:11416127 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005496 Jenn P08516 50549 Cyp4a1 Rattus norvegicus 10116 Comment/tissue specificity Western immunoblotting showed Cyp4a expression in renal arteries obtained from rats subject to either normal salt or low salt intake for 10 days renal artery BTO:0001165 Y Y ECO:0000006 PubMed:12419775 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005497 Jenn P08516 50549 Cyp4a1 Rattus norvegicus 10116 Comment/tissue specificity Western immunoblotting showed Cyp4a expression in renal arteries obtained from rats subject to either normal salt or low salt intake for 10 days renal artery UBERON:0001184 Y Y ECO:0000006 PubMed:12419775 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005498 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Western immunoblotting showed an increase in Cox2 expression in renal arteries obtained from rats subject to elow salt intake for 10 days renal artery BTO:0001165 Y Y ECO:0000006 PubMed:12419775 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005499 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Western immunoblotting showed an increase in Cox2 expression in renal arteries obtained from rats subject to elow salt intake for 10 days renal artery UBERON:0001184 Y Y ECO:0000006 PubMed:12419775 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005500 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity Western immunoblotting showed Cox1 expression in renal arteries obtained from rats subject to either normal salt or low salt intake for 10 days renal artery BTO:0001165 Y Y ECO:0000006 PubMed:12419775 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005501 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity Western immunoblotting showed Cox1 expression in renal arteries obtained from rats subject to either normal salt or low salt intake for 10 days renal artery UBERON:0001184 Y Y ECO:0000006 PubMed:12419775 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005502 Jenn P14423 29692 Pla2g2a Rattus norvegicus 10116 Comment/tissue specificity In the presence of an additional stimulus, like the proinflammatory cytokine IL-1β, hypoxia accelerate sPLA2-IIA expression and activity in rat renal mesangial cells mesangium BTO:0002494 glomerular mesangial cell CL:1000742 Y Y ECO:0000006 PubMed:16135775 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; hypoxia and IL-1β inducible, nitric oxide and IL-1β inducible, PPARG and IL-1β inducible AAP 4/21/2014 3 3300005513 Jenn P14423 29692 Pla2g2a Rattus norvegicus 10116 Comment/tissue specificity In the presence of an additional stimulus, like the proinflammatory cytokine IL-1β, hypoxia accelerate sPLA2-IIA expression and activity in rat renal mesangial cells glomerular mesangium UBERON:0002320 glomerular mesangial cell CL:1000742 Y Y ECO:0000006 PubMed:16135775 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; hypoxia and IL-1β inducible, nitric oxide and IL-1β inducible, PPARG and IL-1β inducible AAP 4/21/2014 3 3300005514 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity PCR product identity was verified by restriction digestion, using glomerular cDNA for COX-1 and macula densa cDNA for COX-2 renal glomerulus BTO:0000530 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005544 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity PCR product identity was verified by restriction digestion, using glomerular cDNA for COX-1 and macula densa cDNA for COX-2 renal glomerulus UBERON:0000074 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005545 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity PCR product identity was verified by restriction digestion, using glomerular cDNA for COX-1 and macula densa cDNA for COX-2 macula densa BTO:0003940 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005546 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity PCR product identity was verified by restriction digestion, using glomerular cDNA for COX-1 and macula densa cDNA for COX-2 macula densa UBERON:0002335 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005547 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity By Western blotting, both COX-1 and COX-2 were virtually exclusively localized to inner medulla renal inner medulla BTO:0001745 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005548 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity By Western blotting, both COX-1 and COX-2 were virtually exclusively localized to inner medulla inner medulla of kidney UBERON:0001294 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005549 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity By Western blotting, both COX-1 and COX-2 were virtually exclusively localized to inner medulla renal inner medulla BTO:0001745 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005550 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity By Western blotting, both COX-1 and COX-2 were virtually exclusively localized to inner medulla inner medulla of kidney UBERON:0001294 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005551 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity By both RT-PCR and Western blotting, both COX-1 and COX-2 were abundant in renal interstitial cells kidney interstitial cell CL:1000500 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005552 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity By both RT-PCR and Western blotting, both COX-1 and COX-2 were abundant in renal interstitial cells kidney interstitial cell CL:1000500 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005553 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity COX-1 product was found to be localized in the glomerulus rather than in the adherent tubule. COX-1 was also consistently detected in MTAL and all portions of the collecting duct (CCD, OMCD, and IMCD) renal glomerulus BTO:0000530 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005554 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity COX-1 product was found to be localized in the glomerulus rather than in the adherent tubule. COX-1 was also consistently detected in MTAL and all portions of the collecting duct (CCD, OMCD, and IMCD) renal glomerulus UBERON:0000074 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005555 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity COX-1 product was found to be localized in the glomerulus rather than in the adherent tubule. COX-1 was also consistently detected in MTAL and all portions of the collecting duct (CCD, OMCD, and IMCD) Henles loop BTO:0004608 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005556 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity COX-1 product was found to be localized in the glomerulus rather than in the adherent tubule. COX-1 was also consistently detected in MTAL and all portions of the collecting duct (CCD, OMCD, and IMCD) thick ascending limb of loop of Henle UBERON:0001291 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005557 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity COX-1 product was found to be localized in the glomerulus rather than in the adherent tubule. COX-1 was also consistently detected in MTAL and all portions of the collecting duct (CCD, OMCD, and IMCD) collecting duct BTO:0000761 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005558 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity COX-1 product was found to be localized in the glomerulus rather than in the adherent tubule. COX-1 was also consistently detected in MTAL and all portions of the collecting duct (CCD, OMCD, and IMCD) renal collecting system UBERON:0004100 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005559 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity COX-2 PCR products were regularly and abundantly amplified in cDNA from macula densa containing segment and cortical thick ascending limb of Henle's loop macula densa BTO:0003940 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; expression is upregulated in rats on a low-salt diet; Sprague-Dawley strain AAP 4/21/2014 3 3300005560 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity COX-2 PCR products were regularly and abundantly amplified in cDNA from macula densa containing segment and cortical thick ascending limb of Henle's loop macula densa UBERON:0002335 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; expression is upregulated in rats on a low-salt diet; Sprague-Dawley strain AAP 4/21/2014 3 3300005561 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity COX-2 PCR products were regularly and abundantly amplified in cDNA from macula densa containing segment and cortical thick ascending limb of Henle's loop Henles loop BTO:0004608 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; expression is upregulated in rats on a low-salt diet; Sprague-Dawley strain AAP 4/21/2014 3 3300005562 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity COX-2 PCR products were regularly and abundantly amplified in cDNA from macula densa containing segment and cortical thick ascending limb of Henle's loop thick ascending limb of loop of Henle UBERON:0001291 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; expression is upregulated in rats on a low-salt diet; Sprague-Dawley strain AAP 4/21/2014 3 3300005563 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Sprague-Dawley rats on a high-salt diet (8.0% NaCl; n=6) for 2 weeks led to significantly greater immunoreactive COX-2 protein in the renal medulla compared with rats maintained on a low-sodium diet (0.4% NaCl; n=6) for 2 weeks. renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:15314032 PENTACON From review: PubMed:20059330;inducible: high-salt diet AAP 4/21/2014 3 3300005585 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Sprague-Dawley rats on a high-salt diet (8.0% NaCl; n=6) for 2 weeks led to significantly greater immunoreactive COX-2 protein in the renal medulla compared with rats maintained on a low-sodium diet (0.4% NaCl; n=6) for 2 weeks. renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:15314032 PENTACON From review: PubMed:20059330;inducible: high-salt diet AAP 4/21/2014 3 3300005586 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Chronic infusion of the COX-2 selective inhibitor NS-398 or antisense oligonucleotide for COX-2 into the renal medullary interstitial space in male Sprague-Dawley rats led to a sustained increase in mean arterial blood pressure in rats maintained on a high-salt (4% NaCl) diet. renal medulla BTO:0001167 hypertension DOID:10763 Hypertensive disorder SNOMEDCT:38341003 Y Y ECO:0000006 PubMed:15314032 PENTACON From review: PubMed:20059330;sodium-sensitive hypertension AAP 4/21/2014 3 3300005587 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Chronic infusion of the COX-2 selective inhibitor NS-398 or antisense oligonucleotide for COX-2 into the renal medullary interstitial space in male Sprague-Dawley rats led to a sustained increase in mean arterial blood pressure in rats maintained on a high-salt (4% NaCl) diet. renal medulla UBERON:0000362 hypertension DOID:10763 Hypertensive disorder SNOMEDCT:38341003 Y Y ECO:0000006 PubMed:15314032 PENTACON From review: PubMed:20059330;sodium-sensitive hypertension AAP 4/21/2014 3 3300005588 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity In normal rat kidney fibroblasts PGF2alpha upregulates Cox-2 expression both at the mRNA and protein level, indicating that that activation of the PG-F2alpha receptor in these fibroblasts induces a positive feedback loop in the production of PGF2alpha. fibroblast BTO:0000452 NRK 49F cell CLO:0008196 Y Y ECO:0000006 PubMed:18703136 PENTACON From primary source: PubMed:19376970; From review: PubMed:20059330;Evidence for Heart - fibroblasts Review Fig. 2;inducible: PGF2alpha AAP 4/21/2014 3 3300005597 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity In normal rat kidney fibroblasts PGF2alpha upregulates Cox-2 expression both at the mRNA and protein level, indicating that that activation of the PG-F2alpha receptor in these fibroblasts induces a positive feedback loop in the production of PGF2alpha. kidney UBERON:0002113 NRK 49F cell CLO:0008196 Y Y ECO:0000006 PubMed:18703136 PENTACON From primary source: PubMed:19376970; From review: PubMed:20059330;Evidence for Heart - fibroblasts Review Fig. 2;inducible: PGF2alpha AAP 4/21/2014 3 3300005598 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/Involvement in disease In normal rat kidney fibroblasts PGF2alpha upregulates Cox-2 expression both at the mRNA and protein level, indicating that that activation of the PG-F2alpha receptor in these fibroblasts induces a positive feedback loop in the production of PGF2alpha. kidney UBERON:0002113 fibroblast BTO:0000452 Fibrosis SNOMEDCT:112674009 Y Y ECO:0000006 PubMed:18703136 PENTACON From primary source: PubMed:19376970; From review: PubMed:20059330;Evidence for Heart - fibroblasts Review Fig. 2; Evidence for fibrosis in conjunction with PubMed:12087084 AAP 4/21/2014 3 3300005599 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity In normal rat kidney fibroblasts PGF2alpha upregulates Cox-2 expression both at the mRNA and protein level, indicating that that activation of the PG-F2alpha receptor in these fibroblasts induces a positive feedback loop in the production of PGF2alpha. (PubMed:18703136) Superfusion of cultured, spontaneously beating, neonatal rat cardiac myocytes with PGF2alpha induced tachyarrhythmia. (PubMed:9380795). fibroblast BTO:0000452 NRK 49F cell CLO:0008196 Y Y ECO:0000006 PubMed:18703136 PENTACON From primary source: PubMed:19376970; From review: PubMed:20059330; Evidence for Heart Review Fig. 2; Evidence for arrythmia together with PubMed:9380795 - Fibroblasts form PGF2alpha which induces arrhythmia (tachyarrhythmia) in cardiac myocytes AAP 4/21/2014 3 3300005600 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity In normal rat kidney fibroblasts PGF2alpha upregulates Cox-2 expression both at the mRNA and protein level, indicating that that activation of the PG-F2alpha receptor in these fibroblasts induces a positive feedback loop in the production of PGF2alpha. (PubMed:18703136) Superfusion of cultured, spontaneously beating, neonatal rat cardiac myocytes with PGF2alpha induced tachyarrhythmia. (PubMed:9380795). kidney UBERON:0002113 NRK 49F cell CLO:0008196 Y Y ECO:0000006 PubMed:18703136 PENTACON From primary source: PubMed:19376970; From review: PubMed:20059330; Evidence for Heart Review Fig. 2; Evidence for arrythmia together with PubMed:9380795 - Fibroblasts form PGF2alpha which induces arrhythmia (tachyarrhythmia) in cardiac myocytes AAP 4/21/2014 3 3300005601 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity In situ hybridization and immunohistochemistry indicated that renal cortical COX-2 expression was localized to the macula densa of the juxtaglomerular apparatus and to adjacent epithelial cells of the cortical thick ascending limb of Henle in male Sprague-Dawley rats. In addition, COX-2 immunoreactivity was detected in interstitial cells in the papilla. When animals were chronically sodium restricted (< 25 mg/kg Na+), the level of COX-2 in the region of the macula densa increased threefold and the total area of the COX-2 immunoreactive cells in cortex increased. macula densa BTO:0003940 Y Y ECO:0000006 PubMed:7989609 PENTACON From primary source: PubMed:12093889; From review: PubMed:17361113 AAP 4/21/2014 3 3300005628 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity In situ hybridization and immunohistochemistry indicated that renal cortical COX-2 expression was localized to the macula densa of the juxtaglomerular apparatus and to adjacent epithelial cells of the cortical thick ascending limb of Henle in male Sprague-Dawley rats. In addition, COX-2 immunoreactivity was detected in interstitial cells in the papilla. When animals were chronically sodium restricted (< 25 mg/kg Na+), the level of COX-2 in the region of the macula densa increased threefold and the total area of the COX-2 immunoreactive cells in cortex increased. macula densa UBERON:0002335 Y Y ECO:0000006 PubMed:7989609 PENTACON From primary source: PubMed:12093889; From review: PubMed:17361113 AAP 4/21/2014 3 3300005629 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity In situ hybridization and immunohistochemistry indicated that renal cortical COX-2 expression was localized to the macula densa of the juxtaglomerular apparatus and to adjacent epithelial cells of the cortical thick ascending limb of Henle in male Sprague-Dawley rats. In addition, COX-2 immunoreactivity was detected in interstitial cells in the papilla. When animals were chronically sodium restricted (< 25 mg/kg Na+), the level of COX-2 in the region of the macula densa increased threefold and the total area of the COX-2 immunoreactive cells in cortex increased. Henles loop BTO:0004608 Y Y ECO:0000006 PubMed:7989609 PENTACON From primary source: PubMed:12093889; From review: PubMed:17361113; UBERON term is more specific than BTO term AAP 4/21/2014 3 3300005630 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity In situ hybridization and immunohistochemistry indicated that renal cortical COX-2 expression was localized to the macula densa of the juxtaglomerular apparatus and to adjacent epithelial cells of the cortical thick ascending limb of Henle in male Sprague-Dawley rats. In addition, COX-2 immunoreactivity was detected in interstitial cells in the papilla. When animals were chronically sodium restricted (< 25 mg/kg Na+), the level of COX-2 in the region of the macula densa increased threefold and the total area of the COX-2 immunoreactive cells in cortex increased. thick ascending limb of loop of Henle UBERON:0001291 Y Y ECO:0000006 PubMed:7989609 PENTACON From primary source: PubMed:12093889; From review: PubMed:17361113; UBERON term is more specific than BTO term AAP 4/21/2014 3 3300005631 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity In situ hybridization and immunohistochemistry indicated that renal cortical COX-2 expression was localized to the macula densa of the juxtaglomerular apparatus and to adjacent epithelial cells of the cortical thick ascending limb of Henle in male Sprague-Dawley rats. In addition, COX-2 immunoreactivity was detected in medullary interstitial cells in the papilla with the greatest reactivity at the papillary tip. When animals were chronically sodium restricted (< 25 mg/kg Na+), the level of COX-2 in the region of the macula densa increased threefold and the total area of the COX-2 immunoreactive cells in cortex increased. renal papilla BTO:0003925 kidney medulla interstitial cell CL:1000682 Y Y ECO:0000006 PubMed:7989609 PENTACON From primary source: PubMed:12093889;From review: PubMed:17361113; tissue type and cell type are mixed on this line. UBERON and CL both more specific than BTO AAP 4/21/2014 3 3300005632 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity In situ hybridization and immunohistochemistry indicated that renal cortical COX-2 expression was localized to the macula densa of the juxtaglomerular apparatus and to adjacent epithelial cells of the cortical thick ascending limb of Henle in male Sprague-Dawley rats. In addition, COX-2 immunoreactivity was detected in medullary interstitial cells in the papilla with the greatest reactivity at the papillary tip. When animals were chronically sodium restricted (< 25 mg/kg Na+), the level of COX-2 in the region of the macula densa increased threefold and the total area of the COX-2 immunoreactive cells in cortex increased. tip of renal papilla UBERON:0009095 kidney medulla interstitial cell CL:1000682 Y Y ECO:0000006 PubMed:7989609 PENTACON From primary source: PubMed:12093889;From review: PubMed:17361113; tissue type and cell type are mixed on this line. UBERON and CL both more specific than BTO AAP 4/21/2014 3 3300005633 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity In situ hybridization and immunohistochemistry indicated that renal cortical COX-2 expression was localized to the macula densa of the juxtaglomerular apparatus and to adjacent epithelial cells of the cortical thick ascending limb of Henle in male Sprague-Dawley rats. In addition, COX-2 immunoreactivity was detected in interstitial cells in the papilla. When animals were chronically sodium restricted (< 25 mg/kg Na+), the level of COX-2 in the region of the macula densa increased threefold and the total area of the COX-2 immunoreactive cells in cortex increased. macula densa BTO:0003940 Y Y ECO:0000006 PubMed:7989609 PENTACON From primary source: PubMed:12093889; From review: PubMed:17361113; inducible: low sodium diet AAP 4/21/2014 3 3300005634 Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity In situ hybridization and immunohistochemistry indicated that renal cortical COX-2 expression was localized to the macula densa of the juxtaglomerular apparatus and to adjacent epithelial cells of the cortical thick ascending limb of Henle in male Sprague-Dawley rats. In addition, COX-2 immunoreactivity was detected in interstitial cells in the papilla. When animals were chronically sodium restricted (< 25 mg/kg Na+), the level of COX-2 in the region of the macula densa increased threefold and the total area of the COX-2 immunoreactive cells in cortex increased. macula densa UBERON:0002335 Y Y ECO:0000006 PubMed:7989609 PENTACON From primary source: PubMed:12093889; From review: PubMed:17361113; inducible: low sodium diet AAP 4/21/2014 3 3300005635 Faith Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity In male Sprague-Dawley rats COX-1 immunoreactivity was greatest in medullary collecting ducts and medullary interstitial cells, with much less intense staining in cortical collecting tubules. medullary collecting duct BTO:0004536 Y Y ECO:0000006 PubMed:7989609 PENTACON From primary source: PubMed:12093889; From review: PubMed:17361113 AAP 4/21/2014 3 3300005636 Faith Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity In male Sprague-Dawley rats COX-1 immunoreactivity was greatest in medullary collecting ducts and medullary interstitial cells, with much less intense staining in cortical collecting tubules. renal medulla collecting duct UBERON:0005185 Y Y ECO:0000006 PubMed:7989609 PENTACON From primary source: PubMed:12093889; From review: PubMed:17361113 AAP 4/21/2014 3 3300005637 Faith Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity In male Sprague-Dawley rats COX-1 immunoreactivity was greatest in medullary collecting ducts and medullary interstitial cells, with much less intense staining in cortical collecting tubules. kidney medulla interstitial cell CL:1000682 Y Y ECO:0000006 PubMed:7989609 PENTACON From primary source: PubMed:12093889; From review: PubMed:17361113 AAP 4/21/2014 3 3300005638 Faith Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity In male Sprague-Dawley rats COX-1 immunoreactivity was greatest in medullary collecting ducts and medullary interstitial cells, with much less intense staining in cortical collecting tubules. cortical collecting duct BTO:0002643 Y Y ECO:0000006 PubMed:7989609 PENTACON From primary source: PubMed:12093889; From review: PubMed:17361113; much less intense staining AAP 4/21/2014 3 3300005639 Faith Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity In male Sprague-Dawley rats COX-1 immunoreactivity was greatest in medullary collecting ducts and medullary interstitial cells, with much less intense staining in cortical collecting tubules. cortical collecting duct UBERON:0004203 Y Y ECO:0000006 PubMed:7989609 PENTACON From primary source: PubMed:12093889; From review: PubMed:17361113; much less intense staining AAP 4/21/2014 3 3300005640 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Cyclooxygenase-2 mRNA was highly expressed in glomeruli and in cTAL. Lower COX-2 mRNA levels were detected in CT/CCD and IMCD. No COX-2 mRNA expression was found in all other nephron segments tested renal glomerulus BTO:0000530 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005642 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Cyclooxygenase-2 mRNA was highly expressed in glomeruli and in cTAL. Lower COX-2 mRNA levels were detected in CT/CCD and IMCD. No COX-2 mRNA expression was found in all other nephron segments tested renal glomerulus UBERON:0000074 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005643 Jenn P22057 25526 Ptgds Rattus norvegicus 10116 Comment/tissue specificity The L-PGD synthase was strongly expressed and widely distributed within the cortex and outer medulla of the kidney. Figure 3 (upper panel) shows a representative agarose gel of the L-PGD synthase mRNA localization in the nephron segments. The PCR-product (32 cycles) was detected in PCT, mTAL, cTAL, DCT, CT/CCD, and OMCD. renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005644 Jenn P22057 25526 Ptgds Rattus norvegicus 10116 Comment/tissue specificity The L-PGD synthase was strongly expressed and widely distributed within the cortex and outer medulla of the kidney. Figure 3 (upper panel) shows a representative agarose gel of the L-PGD synthase mRNA localization in the nephron segments. The PCR-product (32 cycles) was detected in PCT, mTAL, cTAL, DCT, CT/CCD, and OMCD. cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005645 Jenn P22057 25526 Ptgds Rattus norvegicus 10116 Comment/tissue specificity The L-PGD synthase was strongly expressed and widely distributed within the cortex and outer medulla of the kidney. Figure 3 (upper panel) shows a representative agarose gel of the L-PGD synthase mRNA localization in the nephron segments. The PCR-product (32 cycles) was detected in PCT, mTAL, cTAL, DCT, CT/CCD, and OMCD. renal outer medulla BTO:0001746 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005646 Jenn P22057 25526 Ptgds Rattus norvegicus 10116 Comment/tissue specificity The L-PGD synthase was strongly expressed and widely distributed within the cortex and outer medulla of the kidney. Figure 3 (upper panel) shows a representative agarose gel of the L-PGD synthase mRNA localization in the nephron segments. The PCR-product (32 cycles) was detected in PCT, mTAL, cTAL, DCT, CT/CCD, and OMCD. outer medulla of kidney UBERON:0001293 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005647 Jenn Q9JHF3 59103 Ptges Rattus norvegicus 10116 Comment/tissue specificity Immunostaining of membrane-associated PGE synthase using sections of kidney tissue of untreated rats (N = 5) revealed immunoreactivity in collecting duct tubules of the cortex, and outer and inner medullas collecting duct BTO:0000761 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005648 Jenn Q9JHF3 59103 Ptges Rattus norvegicus 10116 Comment/tissue specificity Immunostaining of membrane-associated PGE synthase using sections of kidney tissue of untreated rats (N = 5) revealed immunoreactivity in collecting duct tubules of the cortex, and outer and inner medullas collecting duct of renal tubule UBERON:0001232 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005649 Jenn O35543 58962 Hpgds Rattus norvegicus 10116 Comment/tissue specificity The RT-PCR (34 cycles) of the H-PGD synthase mRNA revealed a very weak overall expression of H-PGD-synthase in the whole kidney kidney BTO:0000671 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005650 Jenn O35543 58962 Hpgds Rattus norvegicus 10116 Comment/tissue specificity The RT-PCR (34 cycles) of the H-PGD synthase mRNA revealed a very weak overall expression of H-PGD-synthase in the whole kidney kidney UBERON:0002113 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005651 Jenn Q62969 25527 Ptgis Rattus norvegicus 10116 Comment/tissue specificity PGI synthase mRNA was detected in cDNA derived from the whole kidney (34 cycles), but PGI synthase mRNA was not found in any nephron segment kidney BTO:0000671 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005652 Jenn Q62969 25527 Ptgis Rattus norvegicus 10116 Comment/tissue specificity PGI synthase mRNA was detected in cDNA derived from the whole kidney (34 cycles), but PGI synthase mRNA was not found in any nephron segment kidney UBERON:0002113 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005653 Jenn P49430 24886 Tbxas1 Rattus norvegicus 10116 Comment/tissue specificity the TXA synthase mRNA level was rather low in the whole kidney and in glomeruli kidney BTO:0000671 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005654 Jenn P49430 24886 Tbxas1 Rattus norvegicus 10116 Comment/tissue specificity the TXA synthase mRNA level was rather low in the whole kidney and in glomeruli kidney UBERON:0002113 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005655 Jenn P22057 25526 Ptgds Rattus norvegicus 10116 Comment/tissue specificity The L-PGD synthase was strongly expressed and widely distributed within the cortex and outer medulla of the kidney. Figure 3 (upper panel) shows a representative agarose gel of the L-PGD synthase mRNA localization in the nephron segments. The PCR-product (32 cycles) was detected in PCT, mTAL, cTAL, DCT, CT/CCD, and OMCD. nephron BTO:0000924 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005656 Jenn P22057 25526 Ptgds Rattus norvegicus 10116 Comment/tissue specificity The L-PGD synthase was strongly expressed and widely distributed within the cortex and outer medulla of the kidney. Figure 3 (upper panel) shows a representative agarose gel of the L-PGD synthase mRNA localization in the nephron segments. The PCR-product (32 cycles) was detected in PCT, mTAL, cTAL, DCT, CT/CCD, and OMCD. nephron UBERON:0001285 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005657 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Cyclooxygenase-2 mRNA was highly expressed in glomeruli and in cTAL. Lower COX-2 mRNA levels were detected in CT/CCD and IMCD. No COX-2 mRNA expression was found in all other nephron segments tested cortical collecting duct BTO:0002643 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005662 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Cyclooxygenase-2 mRNA was highly expressed in glomeruli and in cTAL. Lower COX-2 mRNA levels were detected in CT/CCD and IMCD. No COX-2 mRNA expression was found in all other nephron segments tested cortical collecting duct UBERON:0004203 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005663 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Cyclooxygenase-2 mRNA was highly expressed in glomeruli and in cTAL. Lower COX-2 mRNA levels were detected in CT/CCD and IMCD. No COX-2 mRNA expression was found in all other nephron segments tested inner medullary collecting duct BTO:0004544 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005664 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Cyclooxygenase-2 mRNA was highly expressed in glomeruli and in cTAL. Lower COX-2 mRNA levels were detected in CT/CCD and IMCD. No COX-2 mRNA expression was found in all other nephron segments tested inner medullary collecting duct UBERON:0004205 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005665 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Cyclooxygenase-2 mRNA was highly expressed in glomeruli and in cTAL. Lower COX-2 mRNA levels were detected in CT/CCD and IMCD. No COX-2 mRNA expression was found in all other nephron segments tested Henles loop BTO:0004608 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005666 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Cyclooxygenase-2 mRNA was highly expressed in glomeruli and in cTAL. Lower COX-2 mRNA levels were detected in CT/CCD and IMCD. No COX-2 mRNA expression was found in all other nephron segments tested thick ascending limb of loop of Henle UBERON:0001291 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005667 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity In the microdissected segments COX-1 mRNA (Figure 2a, upper panel) was highly abundant in connecting tubule and cortical collecting duct (CT/CCD), outer medullary and inner medullary collecting duct (OMCD and IMCD, respectively). A weak COX-1 mRNA expression was observed in glomeruli and in outer medullary descending thin limb of Henle's loop (DTL). The COX-1 mRNA was absent in all other nephron segments tested, proximal convoluted tubule (PCT), proximal straight tubule (PST), inner medullary descending and ascending thin limb of Henle (TL), medullary and cortical thick ascending limb of Henle's loop (mTAL and cTAL, respectively), and distal convoluted tubule (DCT). connecting tubule BTO:0004539 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005668 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity In the microdissected segments COX-1 mRNA (Figure 2a, upper panel) was highly abundant in connecting tubule and cortical collecting duct (CT/CCD), outer medullary and inner medullary collecting duct (OMCD and IMCD, respectively). A weak COX-1 mRNA expression was observed in glomeruli and in outer medullary descending thin limb of Henle's loop (DTL). The COX-1 mRNA was absent in all other nephron segments tested, proximal convoluted tubule (PCT), proximal straight tubule (PST), inner medullary descending and ascending thin limb of Henle (TL), medullary and cortical thick ascending limb of Henle's loop (mTAL and cTAL, respectively), and distal convoluted tubule (DCT). renal connecting tubule UBERON:0005097 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005669 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity In the microdissected segments COX-1 mRNA (Figure 2a, upper panel) was highly abundant in connecting tubule and cortical collecting duct (CT/CCD), outer medullary and inner medullary collecting duct (OMCD and IMCD, respectively). A weak COX-1 mRNA expression was observed in glomeruli and in outer medullary descending thin limb of Henle's loop (DTL). The COX-1 mRNA was absent in all other nephron segments tested, proximal convoluted tubule (PCT), proximal straight tubule (PST), inner medullary descending and ascending thin limb of Henle (TL), medullary and cortical thick ascending limb of Henle's loop (mTAL and cTAL, respectively), and distal convoluted tubule (DCT). medullary collecting duct BTO:0004536 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005670 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity In the microdissected segments COX-1 mRNA (Figure 2a, upper panel) was highly abundant in connecting tubule and cortical collecting duct (CT/CCD), outer medullary and inner medullary collecting duct (OMCD and IMCD, respectively). A weak COX-1 mRNA expression was observed in glomeruli and in outer medullary descending thin limb of Henle's loop (DTL). The COX-1 mRNA was absent in all other nephron segments tested, proximal convoluted tubule (PCT), proximal straight tubule (PST), inner medullary descending and ascending thin limb of Henle (TL), medullary and cortical thick ascending limb of Henle's loop (mTAL and cTAL, respectively), and distal convoluted tubule (DCT). renal medulla collecting duct UBERON:0005185 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005671 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity In the microdissected segments COX-1 mRNA (Figure 2a, upper panel) was highly abundant in connecting tubule and cortical collecting duct (CT/CCD), outer medullary and inner medullary collecting duct (OMCD and IMCD, respectively). A weak COX-1 mRNA expression was observed in glomeruli and in outer medullary descending thin limb of Henle's loop (DTL). The COX-1 mRNA was absent in all other nephron segments tested, proximal convoluted tubule (PCT), proximal straight tubule (PST), inner medullary descending and ascending thin limb of Henle (TL), medullary and cortical thick ascending limb of Henle's loop (mTAL and cTAL, respectively), and distal convoluted tubule (DCT). cortical collecting duct BTO:0002643 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005672 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity In the microdissected segments COX-1 mRNA (Figure 2a, upper panel) was highly abundant in connecting tubule and cortical collecting duct (CT/CCD), outer medullary and inner medullary collecting duct (OMCD and IMCD, respectively). A weak COX-1 mRNA expression was observed in glomeruli and in outer medullary descending thin limb of Henle's loop (DTL). The COX-1 mRNA was absent in all other nephron segments tested, proximal convoluted tubule (PCT), proximal straight tubule (PST), inner medullary descending and ascending thin limb of Henle (TL), medullary and cortical thick ascending limb of Henle's loop (mTAL and cTAL, respectively), and distal convoluted tubule (DCT). cortical collecting duct UBERON:0004203 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005673 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity In the microdissected segments COX-1 mRNA (Figure 2a, upper panel) was highly abundant in connecting tubule and cortical collecting duct (CT/CCD), outer medullary and inner medullary collecting duct (OMCD and IMCD, respectively). A weak COX-1 mRNA expression was observed in glomeruli and in outer medullary descending thin limb of Henle's loop (DTL). The COX-1 mRNA was absent in all other nephron segments tested, proximal convoluted tubule (PCT), proximal straight tubule (PST), inner medullary descending and ascending thin limb of Henle (TL), medullary and cortical thick ascending limb of Henle's loop (mTAL and cTAL, respectively), and distal convoluted tubule (DCT). renal glomerulus BTO:0000530 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005674 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity In the microdissected segments COX-1 mRNA (Figure 2a, upper panel) was highly abundant in connecting tubule and cortical collecting duct (CT/CCD), outer medullary and inner medullary collecting duct (OMCD and IMCD, respectively). A weak COX-1 mRNA expression was observed in glomeruli and in outer medullary descending thin limb of Henle's loop (DTL). The COX-1 mRNA was absent in all other nephron segments tested, proximal convoluted tubule (PCT), proximal straight tubule (PST), inner medullary descending and ascending thin limb of Henle (TL), medullary and cortical thick ascending limb of Henle's loop (mTAL and cTAL, respectively), and distal convoluted tubule (DCT). renal glomerulus UBERON:0000074 Y Y ECO:0000006 PubMed:12371957 PENTACON From review: PubMed:17361113; From review: PubMed:19095631; Sprague-Dawley strain AAP 4/21/2014 3 3300005675 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Western blot analysis revealed increased expression of COX-2 immunoreactive protein in the renal cortex of diabetic rats as compared with control animals or diabetic rats on intensive insulin treatment renal cortex BTO:0001166 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:11285308 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005708 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Western blot analysis revealed increased expression of COX-2 immunoreactive protein in the renal cortex of diabetic rats as compared with control animals or diabetic rats on intensive insulin treatment cortex of kidney UBERON:0001225 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:11285308 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005709 Jenn/Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Western blot analysis revealed increased expression of COX-2 immunoreactive protein in the renal cortex of diabetic rats as compared with control animals or diabetic rats on intensive insulin treatment renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:11285308 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005710 Jenn/Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Western blot analysis revealed increased expression of COX-2 immunoreactive protein in the renal cortex of diabetic rats as compared with control animals or diabetic rats on intensive insulin treatment cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:11285308 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005711 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity Immunohistochemical studies showed expression of COX-1 protein in collecting ducts. collecting duct BTO:0000761 Y Y ECO:0000006 PubMed:11285308 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005712 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity Immunohistochemical studies showed expression of COX-1 protein in collecting ducts. collecting duct of renal tubule UBERON:0001232 Y Y ECO:0000006 PubMed:11285308 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005713 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Zucker diabetic fatty rats demonstrated increases in renal cortical COX-2 protein expression as compared to Zucker lean rats renal cortex BTO:0001166 type 2 diabetes mellitus DOID:9352 Y Y ECO:0000006 PubMed:15882258 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005714 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Zucker diabetic fatty rats demonstrated increases in renal cortical COX-2 protein expression as compared to Zucker lean rats cortex of kidney UBERON:0001225 type 2 diabetes mellitus DOID:9352 Y Y ECO:0000006 PubMed:15882258 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005715 Jenn/Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Zucker diabetic fatty rats demonstrated increases in renal cortical COX-2 protein expression as compared to Zucker lean rats renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:15882258 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005716 Jenn/Faith P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Zucker diabetic fatty rats demonstrated increases in renal cortical COX-2 protein expression as compared to Zucker lean rats cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:15882258 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005717 Jenn Q02759 81639 Alox15 Rattus norvegicus 10116 Comment/tissue specificity 15-LOX showed rising abundance from the cortex to the inner medulla. We found weak expression of 15-LOX mRNA in the distal nephron beginning in the cTAL and the DCT, and strong expression along the whole collecting duct renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005778 Jenn Q02759 81639 Alox15 Rattus norvegicus 10116 Comment/tissue specificity 15-LOX showed rising abundance from the cortex to the inner medulla. We found weak expression of 15-LOX mRNA in the distal nephron beginning in the cTAL and the DCT, and strong expression along the whole collecting duct cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005779 Jenn Q02759 81639 Alox15 Rattus norvegicus 10116 Comment/tissue specificity 15-LOX showed rising abundance from the cortex to the inner medulla. We found weak expression of 15-LOX mRNA in the distal nephron beginning in the cTAL and the DCT, and strong expression along the whole collecting duct renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005780 Jenn Q02759 81639 Alox15 Rattus norvegicus 10116 Comment/tissue specificity 15-LOX showed rising abundance from the cortex to the inner medulla. We found weak expression of 15-LOX mRNA in the distal nephron beginning in the cTAL and the DCT, and strong expression along the whole collecting duct renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005781 Jenn Q02759 81639 Alox15 Rattus norvegicus 10116 Comment/tissue specificity 15-LOX showed rising abundance from the cortex to the inner medulla. We found weak expression of 15-LOX mRNA in the distal nephron beginning in the cTAL and the DCT, and strong expression along the whole collecting duct collecting duct BTO:0000761 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005782 Jenn Q02759 81639 Alox15 Rattus norvegicus 10116 Comment/tissue specificity 15-LOX showed rising abundance from the cortex to the inner medulla. We found weak expression of 15-LOX mRNA in the distal nephron beginning in the cTAL and the DCT, and strong expression along the whole collecting duct collecting duct of renal tubule UBERON:0001232 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005783 Jenn F1LQ70 287454 Alox12 Rattus norvegicus 10116 Comment/tissue specificity 12-LOX mRNA abundance was equally low in the cortex, outer medulla, and inner medulla. We observed 12-LOX mRNA expression in microdissected nephron segments only in the glomerulus renal glomerulus BTO:0000530 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005784 Jenn F1LQ70 287454 Alox12 Rattus norvegicus 10116 Comment/tissue specificity 12-LOX mRNA abundance was equally low in the cortex, outer medulla, and inner medulla. We observed 12-LOX mRNA expression in microdissected nephron segments only in the glomerulus renal glomerulus UBERON:0000074 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005785 Jenn P12527 25290 Alox5 Rattus norvegicus 10116 Comment/tissue specificity 5-LOX and FLAP expression in the cortex, outer medulla, and inner medulla was at about the same level in all three zones, but the expression of FLAP mRNAs was higher than 5-LOX expression. For 5-LOX, we found mRNA signals in the glomerulus and in vasa recta renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005786 Jenn P12527 25290 Alox5 Rattus norvegicus 10116 Comment/tissue specificity 5-LOX and FLAP expression in the cortex, outer medulla, and inner medulla was at about the same level in all three zones, but the expression of FLAP mRNAs was higher than 5-LOX expression. For 5-LOX, we found mRNA signals in the glomerulus and in vasa recta cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005787 Jenn P12527 25290 Alox5 Rattus norvegicus 10116 Comment/tissue specificity 5-LOX and FLAP expression in the cortex, outer medulla, and inner medulla was at about the same level in all three zones, but the expression of FLAP mRNAs was higher than 5-LOX expression. For 5-LOX, we found mRNA signals in the glomerulus and in vasa recta renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005788 Jenn P12527 25290 Alox5 Rattus norvegicus 10116 Comment/tissue specificity 5-LOX and FLAP expression in the cortex, outer medulla, and inner medulla was at about the same level in all three zones, but the expression of FLAP mRNAs was higher than 5-LOX expression. For 5-LOX, we found mRNA signals in the glomerulus and in vasa recta renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005789 Jenn P12527 25290 Alox5 Rattus norvegicus 10116 Comment/tissue specificity 5-LOX and FLAP expression in the cortex, outer medulla, and inner medulla was at about the same level in all three zones, but the expression of FLAP mRNAs was higher than 5-LOX expression. For 5-LOX, we found mRNA signals in the glomerulus and in vasa recta renal glomerulus BTO:0000530 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005790 Jenn P12527 25290 Alox5 Rattus norvegicus 10116 Comment/tissue specificity 5-LOX and FLAP expression in the cortex, outer medulla, and inner medulla was at about the same level in all three zones, but the expression of FLAP mRNAs was higher than 5-LOX expression. For 5-LOX, we found mRNA signals in the glomerulus and in vasa recta renal glomerulus UBERON:0000074 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005791 Jenn P12527 25290 Alox5 Rattus norvegicus 10116 Comment/tissue specificity 5-LOX and FLAP expression in the cortex, outer medulla, and inner medulla was at about the same level in all three zones, but the expression of FLAP mRNAs was higher than 5-LOX expression. For 5-LOX, we found mRNA signals in the glomerulus and in vasa recta vasa recta UBERON:0004726 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005792 Jenn P20291 29624 Alox5ap Rattus norvegicus 10116 Comment/tissue specificity 5-LOX and FLAP expression in the cortex, outer medulla, and inner medulla was at about the same level in all three zones, but the expression of FLAP mRNAs was higher than 5-LOX expression.. The mRNA for 5-LOX-activating protein showed the same expression pattern as the mRNA for 5-LOX in microdissected nephron segments, with additional weak expression along the distal nephron from the mTAL to OMCD renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005793 Jenn P20291 29624 Alox5ap Rattus norvegicus 10116 Comment/tissue specificity 5-LOX and FLAP expression in the cortex, outer medulla, and inner medulla was at about the same level in all three zones, but the expression of FLAP mRNAs was higher than 5-LOX expression.. The mRNA for 5-LOX-activating protein showed the same expression pattern as the mRNA for 5-LOX in microdissected nephron segments, with additional weak expression along the distal nephron from the mTAL to OMCD cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005794 Jenn P20291 29624 Alox5ap Rattus norvegicus 10116 Comment/tissue specificity 5-LOX and FLAP expression in the cortex, outer medulla, and inner medulla was at about the same level in all three zones, but the expression of FLAP mRNAs was higher than 5-LOX expression.. The mRNA for 5-LOX-activating protein showed the same expression pattern as the mRNA for 5-LOX in microdissected nephron segments, with additional weak expression along the distal nephron from the mTAL to OMCD renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005795 Jenn P20291 29624 Alox5ap Rattus norvegicus 10116 Comment/tissue specificity 5-LOX and FLAP expression in the cortex, outer medulla, and inner medulla was at about the same level in all three zones, but the expression of FLAP mRNAs was higher than 5-LOX expression.. The mRNA for 5-LOX-activating protein showed the same expression pattern as the mRNA for 5-LOX in microdissected nephron segments, with additional weak expression along the distal nephron from the mTAL to OMCD renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005796 Jenn P20291 29624 Alox5ap Rattus norvegicus 10116 Comment/tissue specificity 5-LOX and FLAP expression in the cortex, outer medulla, and inner medulla was at about the same level in all three zones, but the expression of FLAP mRNAs was higher than 5-LOX expression.. The mRNA for 5-LOX-activating protein showed the same expression pattern as the mRNA for 5-LOX in microdissected nephron segments, with additional weak expression along the distal nephron from the mTAL to OMCD renal glomerulus BTO:0000530 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005797 Jenn P20291 29624 Alox5ap Rattus norvegicus 10116 Comment/tissue specificity 5-LOX and FLAP expression in the cortex, outer medulla, and inner medulla was at about the same level in all three zones, but the expression of FLAP mRNAs was higher than 5-LOX expression.. The mRNA for 5-LOX-activating protein showed the same expression pattern as the mRNA for 5-LOX in microdissected nephron segments, with additional weak expression along the distal nephron from the mTAL to OMCD renal glomerulus UBERON:0000074 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005798 Jenn P20291 29624 Alox5ap Rattus norvegicus 10116 Comment/tissue specificity 5-LOX and FLAP expression in the cortex, outer medulla, and inner medulla was at about the same level in all three zones, but the expression of FLAP mRNAs was higher than 5-LOX expression.. The mRNA for 5-LOX-activating protein showed the same expression pattern as the mRNA for 5-LOX in microdissected nephron segments, with additional weak expression along the distal nephron from the mTAL to OMCD vasa recta UBERON:0004726 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005799 Jenn P30349 299732 Lta4h Rattus norvegicus 10116 Comment/tissue specificity LTA4 hydrolase mRNA expression was remarkably higher than LTC4 synthase mRNA expression, which even decreased from the cortex to the inner medulla. LTA4 hydrolase mRNA showed high abundance in all nephron segments except the outer medullary vasa recta, where we found weaker expression. LTC4 synthase mRNA was detected in whole kidney, but not in any of the microdissected nephron segments nephron BTO:0000924 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005800 Jenn P30349 299732 Lta4h Rattus norvegicus 10116 Comment/tissue specificity LTA4 hydrolase mRNA expression was remarkably higher than LTC4 synthase mRNA expression, which even decreased from the cortex to the inner medulla. LTA4 hydrolase mRNA showed high abundance in all nephron segments except the outer medullary vasa recta, where we found weaker expression. LTC4 synthase mRNA was detected in whole kidney, but not in any of the microdissected nephron segments nephron UBERON:0001285 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005801 Jenn Q925U2 114097 Ltc4s Rattus norvegicus 10116 Comment/tissue specificity LTA4 hydrolase mRNA expression was remarkably higher than LTC4 synthase mRNA expression, which even decreased from the cortex to the inner medulla. LTA4 hydrolase mRNA showed high abundance in all nephron segments except the outer medullary vasa recta, where we found weaker expression. LTC4 synthase mRNA was detected in whole kidney, but not in any of the microdissected nephron segments kidney BTO:0000671 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005802 Jenn Q925U2 114097 Ltc4s Rattus norvegicus 10116 Comment/tissue specificity LTA4 hydrolase mRNA expression was remarkably higher than LTC4 synthase mRNA expression, which even decreased from the cortex to the inner medulla. LTA4 hydrolase mRNA showed high abundance in all nephron segments except the outer medullary vasa recta, where we found weaker expression. LTC4 synthase mRNA was detected in whole kidney, but not in any of the microdissected nephron segments kidney UBERON:0002113 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005803 Jenn Q9R0Q2 59264 Ltb4r Rattus norvegicus 10116 Comment/tissue specificity the expression of the LTB4 receptor was the strongest, followed by the cys-LT1 receptor, and cys-LT2 receptor expression was the lowest. The mRNAs for cys-LT1 and LTB4 receptors were highly abundant in flushed and nonflushed glomeruli renal glomerulus BTO:0000530 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005804 Jenn Q9R0Q2 59264 Ltb4r Rattus norvegicus 10116 Comment/tissue specificity the expression of the LTB4 receptor was the strongest, followed by the cys-LT1 receptor, and cys-LT2 receptor expression was the lowest. The mRNAs for cys-LT1 and LTB4 receptors were highly abundant in flushed and nonflushed glomeruli renal glomerulus UBERON:0000074 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005805 Jenn Q924T8 114099 Cysltr1 Rattus norvegicus 10116 Comment/tissue specificity the expression of the LTB4 receptor was the strongest, followed by the cys-LT1 receptor, and cys-LT2 receptor expression was the lowest. The mRNAs for cys-LT1 and LTB4 receptors were highly abundant in flushed and nonflushed glomeruli renal glomerulus BTO:0000530 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005806 Jenn Q924T8 114099 Cysltr1 Rattus norvegicus 10116 Comment/tissue specificity the expression of the LTB4 receptor was the strongest, followed by the cys-LT1 receptor, and cys-LT2 receptor expression was the lowest. The mRNAs for cys-LT1 and LTB4 receptors were highly abundant in flushed and nonflushed glomeruli renal glomerulus UBERON:0000074 Y Y ECO:0000006 PubMed:16219916 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005807 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity COX-2 expression was increased by chronic hypoxia in vascular smooth muscle, endothelial cells, and bronchial epithelial cells, whereas COX-1 expression was unaltered lung BTO:0000763 vascular associated smooth muscle cell CL:0000359 Y Y ECO:0000006 PubMed:15492320 PENTACON From review: PubMed:16395396; inducible by hypoxia AAP 4/21/2014 3 3300005826 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity COX-2 expression was increased by chronic hypoxia in vascular smooth muscle, endothelial cells, and bronchial epithelial cells, whereas COX-1 expression was unaltered lung UBERON:0002048 vascular associated smooth muscle cell CL:0000359 Y Y ECO:0000006 PubMed:15492320 PENTACON From review: PubMed:16395396; inducible by hypoxia AAP 4/21/2014 3 3300005827 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity COX-2 expression was increased by chronic hypoxia in vascular smooth muscle, endothelial cells, and bronchial epithelial cells, whereas COX-1 expression was unaltered lung BTO:0000763 endothelial cell CL:0000115 Y Y ECO:0000006 PubMed:15492320 PENTACON From review: PubMed:16395396; inducible by hypoxia AAP 4/21/2014 3 3300005828 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity COX-2 expression was increased by chronic hypoxia in vascular smooth muscle, endothelial cells, and bronchial epithelial cells, whereas COX-1 expression was unaltered lung UBERON:0002048 endothelial cell CL:0000115 Y Y ECO:0000006 PubMed:15492320 PENTACON From review: PubMed:16395396; inducible by hypoxia AAP 4/21/2014 3 3300005829 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity COX-2 expression was increased by chronic hypoxia in vascular smooth muscle, endothelial cells, and bronchial epithelial cells, whereas COX-1 expression was unaltered lung BTO:0000763 bronchial epithelial cell CL:0002328 Y Y ECO:0000006 PubMed:15492320 PENTACON From review: PubMed:16395396; inducible by hypoxia AAP 4/21/2014 3 3300005830 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity COX-2 expression was increased by chronic hypoxia in vascular smooth muscle, endothelial cells, and bronchial epithelial cells, whereas COX-1 expression was unaltered lung UBERON:0002048 bronchial epithelial cell CL:0002328 Y Y ECO:0000006 PubMed:15492320 PENTACON From review: PubMed:16395396; inducible by hypoxia AAP 4/21/2014 3 3300005831 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity COX-1 was constitutively expressed in the normal rat lung, with little COX-2 in the tissue under normoxic conditions lung BTO:0000763 vascular associated smooth muscle cell CL:0000359 Y Y ECO:0000006 PubMed:15492320 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005832 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity COX-1 was constitutively expressed in the normal rat lung, with little COX-2 in the tissue under normoxic conditions lung UBERON:0002048 vascular associated smooth muscle cell CL:0000359 Y Y ECO:0000006 PubMed:15492320 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005833 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity COX-1 was constitutively expressed in the normal rat lung, with little COX-2 in the tissue under normoxic conditions lung BTO:0000763 endothelial cell CL:0000115 Y Y ECO:0000006 PubMed:15492320 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005834 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity COX-1 was constitutively expressed in the normal rat lung, with little COX-2 in the tissue under normoxic conditions lung UBERON:0002048 endothelial cell CL:0000115 Y Y ECO:0000006 PubMed:15492320 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005835 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity COX-1 was constitutively expressed in the normal rat lung, with little COX-2 in the tissue under normoxic conditions lung BTO:0000763 bronchial epithelial cell CL:0002328 Y Y ECO:0000006 PubMed:15492320 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005836 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity COX-1 was constitutively expressed in the normal rat lung, with little COX-2 in the tissue under normoxic conditions lung UBERON:0002048 bronchial epithelial cell CL:0002328 Y Y ECO:0000006 PubMed:15492320 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005837 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Immunohistochemistry showed constitutive expression of COX-1 in cardiac cells and in the myocytes of the diaphragm. COX-2 was absent from the normal heart but was induced 4 hours after the administration of DX (Figure ​(Figure1).1). In contrast, COX-2 expression was absent in the diaphragm of DX-treated rats. cardiac muscle BTO:0000199 cardiac muscle cell CL:0000746 doxorubicin CHEBI:28748 Y Y ECO:0000006 PubMed:11518732 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005838 Jenn P35355 29527 Ptgs2 Rattus norvegicus 10116 Comment/tissue specificity Immunohistochemistry showed constitutive expression of COX-1 in cardiac cells and in the myocytes of the diaphragm. COX-2 was absent from the normal heart but was induced 4 hours after the administration of DX (Figure ​(Figure1).1). In contrast, COX-2 expression was absent in the diaphragm of DX-treated rats. cardiac muscle tissue UBERON:0001133 cardiac muscle cell CL:0000746 doxorubicin CHEBI:28748 Y Y ECO:0000006 PubMed:11518732 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005839 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity Immunohistochemistry showed constitutive expression of COX-1 in cardiac cells and in the myocytes of the diaphragm. COX-2 was absent from the normal heart but was induced 4 hours after the administration of DX (Figure ​(Figure1).1). In contrast, COX-2 expression was absent in the diaphragm of DX-treated rats. cardiac muscle BTO:0000199 cardiac muscle cell CL:0000746 Y Y ECO:0000006 PubMed:11518732 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005840 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity Immunohistochemistry showed constitutive expression of COX-1 in cardiac cells and in the myocytes of the diaphragm. COX-2 was absent from the normal heart but was induced 4 hours after the administration of DX (Figure ​(Figure1).1). In contrast, COX-2 expression was absent in the diaphragm of DX-treated rats. cardiac muscle tissue UBERON:0001133 cardiac muscle cell CL:0000746 Y Y ECO:0000006 PubMed:11518732 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005841 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity Immunohistochemistry showed constitutive expression of COX-1 in cardiac cells and in the myocytes of the diaphragm. COX-2 was absent from the normal heart but was induced 4 hours after the administration of DX (Figure ​(Figure1).1). In contrast, COX-2 expression was absent in the diaphragm of DX-treated rats. diaphragm BTO:0000341 muscle cell CL:0000187 Y Y ECO:0000006 PubMed:11518732 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005842 Jenn Q63921 24693 Ptgs1 Rattus norvegicus 10116 Comment/tissue specificity Immunohistochemistry showed constitutive expression of COX-1 in cardiac cells and in the myocytes of the diaphragm. COX-2 was absent from the normal heart but was induced 4 hours after the administration of DX (Figure ​(Figure1).1). In contrast, COX-2 expression was absent in the diaphragm of DX-treated rats. diaphragm UBERON:0001103 muscle cell CL:0000187 Y Y ECO:0000006 PubMed:11518732 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005843