Curator Name UniProt ID NCBI Gene ID Gene Name Species Name Taxonomy ID Data Type Data Value GO Term GO ID Uberon Term Uberon ID BRENDA Tissue Ontology Term BRENDA Tissue Ontology ID Anatomy Ontology Term Anatomy Ontology ID Phenotype Ontology Term Phenotype Ontology ID Developmental Stage Term (BRENDA) Developmental Stage ID (BRENDA) Cell Type Ontology Term (CTO or CL) Cell Type Ontology ID (CTO or CL) Cell Line Ontology Term (CLO) Cell Line Ontology ID (CLO) PATO Qualifier PATO ID OMIM ID Human Disease Ontology Term Human Disease Ontology ID SNOMED Term SNOMED ID ChEBI Chemical Term ChEBI Chemical ID Secondary Source IDs Secondary Source Notes Reviewed (Y/N) Use (Y/N) Evidence Code Primary Source Secondary Source PENTACON Notes Gene Set Secondary Source Version Date Secondary Source Version PENTACON Annotation No Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues kidney BTO:0000671 Y Y ECO:0000006 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005471 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues kidney UBERON:0002113 Y Y ECO:0000006 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005472 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues lung BTO:0000763 Y Y ECO:0000006 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005473 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues lung UBERON:0002048 Y Y ECO:0000006 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005474 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues spleen BTO:0001281 Y Y ECO:0000006 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005475 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues spleen UBERON:0002106 Y Y ECO:0000006 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005476 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues uterus BTO:0001424 Y Y ECO:0000006 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005477 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues uterus UBERON:0000995 Y Y ECO:0000006 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005478 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues kidney BTO:0000671 hypercalcemia DOID:12678 Hypercalcemia SNOMEDCT:66931009 Y Y ECO:0000033 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005479 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues kidney UBERON:0002113 hypercalcemia DOID:12678 Hypercalcemia SNOMEDCT:66931009 Y Y ECO:0000033 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005480 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues kidney BTO:0000671 diabetic nephropathy DOID:2370 Y Y ECO:0000033 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005481 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues kidney UBERON:0002113 diabetic nephropathy DOID:2370 Y Y ECO:0000033 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005482 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues kidney BTO:0000671 glomerulonephritis DOID:2921 Glomerulonephritis SNOMEDCT:36171008 Y Y ECO:0000033 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005483 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues kidney UBERON:0002113 glomerulonephritis DOID:2921 Glomerulonephritis SNOMEDCT:36171008 Y Y ECO:0000033 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005484 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues cell volume homeostasis GO:0006884 kidney BTO:0000671 Y Y ECO:0000033 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005485 Jenn P47713 18783 Pla2g4a Mus musculus 10090 Comment/tissue specificity Western blot analysis of cPLA2 in mouse kidney and other tissues cell volume homeostasis GO:0006884 kidney UBERON:0002113 Y Y ECO:0000033 PubMed:10215342 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005486 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Immunostaining shows COX-2 upregulation 4 weeks after left common carotid artery ligation in mice carotid artery BTO:0000168 Y Y ECO:0000006 PubMed:16395396 PENTACON AAP 4/21/2014 3 3300005515 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Immunostaining shows COX-2 upregulation 4 weeks after left common carotid artery ligation in mice common carotid artery plus branches UBERON:0001530 Y Y ECO:0000006 PubMed:16395396 PENTACON AAP 4/21/2014 3 3300005516 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cox2 mRNA in primary embryonice fibroblasts and Cox2 mRNA in whole brain lysates from Cox +/+ and Cox-/- mice embryonic fibroblast BTO:0004725 embryo BTO:0000379 fibroblast CL:0000057 Y Y ECO:0000006 PubMed:7477380 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005517 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cox2-/- mice show increased incidence of diffuse myocardial fibrosis and other cardiac abnormalities regulation of cardiac muscle fiber development GO:0055018 myocardium BTO:0000901 Y Y ECO:0000006 PubMed:7477380 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005518 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cox2-/- mice show increased incidence of diffuse myocardial fibrosis and other cardiac abnormalities regulation of cardiac muscle fiber development GO:0055018 myocardium of ventricle UBERON:0001083 Y Y ECO:0000006 PubMed:7477380 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005519 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity LPS induces Cox2 expression in mouse peritoneal macrophage peritoneum BTO:0001472 peritoneal macrophage CL:0000581 Y Y ECO:0000006 PubMed:8521477 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005520 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity LPS induces Cox2 expression in mouse peritoneal macrophage peritoneum UBERON:0002358 peritoneal macrophage CL:0000581 Y Y ECO:0000006 PubMed:8521477 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005521 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Homozygous null Cox2 mice showed kidney lesions, nephropathy and nephron hypoplasia and occasionally supurative peritonitis kidney development GO:0001822 kidney BTO:0000671 Y Y ECO:0000006 PubMed:8521477 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005522 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Homozygous null Cox2 mice showed kidney lesions, nephropathy and nephron hypoplasia and occasionally supurative peritonitis kidney development GO:0001822 kidney UBERON:0002113 Y Y ECO:0000006 PubMed:8521477 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005523 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Homozygous null Cox2 mice showed kidney lesions, nephropathy and nephron hypoplasia and occasionally supurative peritonitis peritoneum BTO:0001472 peritonitis DOID:8283 Peritonitis SNOMEDCT:155797008 Y Y ECO:0000006 PubMed:8521477 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005524 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Homozygous null Cox2 mice showed kidney lesions, nephropathy and nephron hypoplasia and occasionally supurative peritonitis peritoneum UBERON:0002358 peritonitis DOID:8283 Peritonitis SNOMEDCT:155797008 Y Y ECO:0000006 PubMed:8521477 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005525 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity COX-1 was also abundant in collecting duct-derived cells and in primary mesangial cells M-1 collecting duct cell BTO:0004545 kidney collecting duct cell CL:1001225 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005526 Jenn Q9JM51 64292 Ptges Mus musculus 10090 Comment/tissue specificity Immunostaining showing mPGES-1 is expressed in macula densa. mPGES-1 immunoreactivity is intensively present in medullary collecting ducts, low but detectable mPGES-1 immunoreactivity is evident in medullary interstitial cells macula densa BTO:0003940 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005527 Jenn Q9JM51 64292 Ptges Mus musculus 10090 Comment/tissue specificity Immunostaining showing mPGES-1 is expressed in macula densa. mPGES-1 immunoreactivity is intensively present in medullary collecting ducts, low but detectable mPGES-1 immunoreactivity is evident in medullary interstitial cells macula densa UBERON:0002335 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005528 Jenn Q9JM51 64292 Ptges Mus musculus 10090 Comment/tissue specificity Immunostaining showing mPGES-1 is expressed in macula densa. mPGES-1 immunoreactivity is intensively present in medullary collecting ducts, low but detectable mPGES-1 immunoreactivity is evident in medullary interstitial cells medullary collecting duct BTO:0004536 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005529 Jenn Q9JM51 64292 Ptges Mus musculus 10090 Comment/tissue specificity Immunostaining showing mPGES-1 is expressed in macula densa. mPGES-1 immunoreactivity is intensively present in medullary collecting ducts, low but detectable mPGES-1 immunoreactivity is evident in medullary interstitial cells renal medulla collecting duct UBERON:0005185 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005530 Jenn Q9JM51 64292 Ptges Mus musculus 10090 Comment/tissue specificity In situ hybridization of mPGES-1 and immunostaining of COX-1 showing mPGES-1 (black grains, arrow) is colocalized with COX-1 (brown color) in both distal convoluted tubules and cortical collecting ducts renal distal tubule BTO:0000482 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005531 Jenn Q9JM51 64292 Ptges Mus musculus 10090 Comment/tissue specificity In situ hybridization of mPGES-1 and immunostaining of COX-1 showing mPGES-1 (black grains, arrow) is colocalized with COX-1 (brown color) in both distal convoluted tubules and cortical collecting ducts distal convoluted tubule UBERON:0001292 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005532 Jenn Q9JM51 64292 Ptges Mus musculus 10090 Comment/tissue specificity In situ hybridization of mPGES-1 and immunostaining of COX-1 showing mPGES-1 (black grains, arrow) is colocalized with COX-1 (brown color) in both distal convoluted tubules and cortical collecting ducts cortical collecting duct BTO:0002643 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005533 Jenn Q9JM51 64292 Ptges Mus musculus 10090 Comment/tissue specificity In situ hybridization of mPGES-1 and immunostaining of COX-1 showing mPGES-1 (black grains, arrow) is colocalized with COX-1 (brown color) in both distal convoluted tubules and cortical collecting ducts cortical collecting duct UBERON:0004203 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005534 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity In situ hybridization of mPGES-1 and immunostaining of COX-1 showing mPGES-1 (black grains, arrow) is colocalized with COX-1 (brown color) in both distal convoluted tubules and cortical collecting ducts renal distal tubule BTO:0000482 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005535 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity In situ hybridization of mPGES-1 and immunostaining of COX-1 showing mPGES-1 (black grains, arrow) is colocalized with COX-1 (brown color) in both distal convoluted tubules and cortical collecting ducts distal convoluted tubule UBERON:0001292 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005536 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity In situ hybridization of mPGES-1 and immunostaining of COX-1 showing mPGES-1 (black grains, arrow) is colocalized with COX-1 (brown color) in both distal convoluted tubules and cortical collecting ducts cortical collecting duct BTO:0002643 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005537 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity In situ hybridization of mPGES-1 and immunostaining of COX-1 showing mPGES-1 (black grains, arrow) is colocalized with COX-1 (brown color) in both distal convoluted tubules and cortical collecting ducts cortical collecting duct UBERON:0004203 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005538 Jenn Q9JM51 64292 Ptges Mus musculus 10090 Comment/tissue specificity Immunostaining showing mPGES-1 is expressed in macula densa. mPGES-1 immunoreactivity is intensively present in medullary collecting ducts, low but detectable mPGES-1 immunoreactivity is evident in medullary interstitial cells renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005539 Jenn Q9JM51 64292 Ptges Mus musculus 10090 Comment/tissue specificity Immunostaining showing mPGES-1 is expressed in macula densa. mPGES-1 immunoreactivity is intensively present in medullary collecting ducts, low but detectable mPGES-1 immunoreactivity is evident in medullary interstitial cells renal medulla interstitium UBERON:0005211 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005540 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity The high magnification of in situ hybridization of COX-2 and immunostaining of mPGES-1 of the mouse kidney demonstrates COX-2 mRNA expression in the medullary interstitial cells renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005541 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity The high magnification of in situ hybridization of COX-2 and immunostaining of mPGES-1 of the mouse kidney demonstrates COX-2 mRNA expression in the medullary interstitial cells renal medulla interstitium UBERON:0005211 Y Y ECO:0000006 PubMed:15086459 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005542 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity COX-1 was also abundant in collecting duct-derived cells and in primary mesangial cells mesangial cell CL:0000650 Y Y ECO:0000006 PubMed:9530264 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005543 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In control mice (mixed B6/129 background), there was sparse immunoreactive COX-2 expression in macula densa cells and surrounding cTALH. Treatment with the ACE inhibitor captopril increased expression of macula densa COX-2 expression, similar to that seen in rats. In control +/- mice, renal cortical COX-2 expression was less than in +/+ mice, and captopril also induced COX-2. Treatment with captopril increased renal renin mRNA expression in +/+ mice and plasma renin activity. COX-2 KO mice failed to increase renin expression in response to inhibition of ANG II production with ACE inhitor captopril, indicating an important role for COX-2 in regulation of renin. macula densa BTO:0003940 Y Y ECO:0000006 PubMed:11181406 PENTACON From primary source: PubMed:12093889 AAP 4/21/2014 3 3300005564 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In control mice (mixed B6/129 background), there was sparse immunoreactive COX-2 expression in macula densa cells and surrounding cTALH. Treatment with the ACE inhibitor captopril increased expression of macula densa COX-2 expression, similar to that seen in rats. In control +/- mice, renal cortical COX-2 expression was less than in +/+ mice, and captopril also induced COX-2. Treatment with captopril increased renal renin mRNA expression in +/+ mice and plasma renin activity. COX-2 KO mice failed to increase renin expression in response to inhibition of ANG II production with ACE inhitor captopril, indicating an important role for COX-2 in regulation of renin. macula densa UBERON:0002335 Y Y ECO:0000006 PubMed:11181406 PENTACON From primary source: PubMed:12093889 AAP 4/21/2014 3 3300005565 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In control mice (mixed B6/129 background), there was sparse immunoreactive COX-2 expression in macula densa cells and surrounding cTALH. Treatment with the ACE inhibitor captopril increased expression of macula densa COX-2 expression, similar to that seen in rats. In control +/- mice, renal cortical COX-2 expression was less than in +/+ mice, and captopril also induced COX-2. Treatment with captopril increased renal renin mRNA expression in +/+ mice and plasma renin activity. COX-2 KO mice failed to increase renin expression in response to inhibition of ANG II production with ACE inhitor captopril, indicating an important role for COX-2 in regulation of renin. Henles loop BTO:0004608 Y Y ECO:0000006 PubMed:11181406 PENTACON From primary source: PubMed:12093889;UBERON term is more specific than BTO term AAP 4/21/2014 3 3300005566 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In control mice (mixed B6/129 background), there was sparse immunoreactive COX-2 expression in macula densa cells and surrounding cTALH. Treatment with the ACE inhibitor captopril increased expression of macula densa COX-2 expression, similar to that seen in rats. In control +/- mice, renal cortical COX-2 expression was less than in +/+ mice, and captopril also induced COX-2. Treatment with captopril increased renal renin mRNA expression in +/+ mice and plasma renin activity. COX-2 KO mice failed to increase renin expression in response to inhibition of ANG II production with ACE inhitor captopril, indicating an important role for COX-2 in regulation of renin. thick ascending limb of loop of Henle UBERON:0001291 Y Y ECO:0000006 PubMed:11181406 PENTACON From primary source: PubMed:12093889;UBERON term is more specific than BTO term AAP 4/21/2014 3 3300005567 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In control mice (mixed B6/129 background), there was sparse immunoreactive COX-2 expression in macula densa cells and surrounding cTALH. Treatment with the ACE inhibitor captopril increased expression of macula densa COX-2 expression, similar to that seen in rats. In control +/- mice, renal cortical COX-2 expression was less than in +/+ mice, and captopril also induced COX-2. Treatment with captopril increased renal renin mRNA expression in +/+ mice and plasma renin activity. COX-2 KO mice failed to increase renin expression in response to inhibition of ANG II production with ACE inhitor captopril, indicating an important role for COX-2 in regulation of renin. positive regulation of renin secretion into blood stream GO:1900135 macula densa BTO:0003940 Y Y ECO:0000006 PubMed:11181406 PENTACON From primary source: PubMed:12093889;inducible:captopril AAP 4/21/2014 3 3300005568 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In control mice (mixed B6/129 background), there was sparse immunoreactive COX-2 expression in macula densa cells and surrounding cTALH. Treatment with the ACE inhibitor captopril increased expression of macula densa COX-2 expression, similar to that seen in rats. In control +/- mice, renal cortical COX-2 expression was less than in +/+ mice, and captopril also induced COX-2. Treatment with captopril increased renal renin mRNA expression in +/+ mice and plasma renin activity. COX-2 KO mice failed to increase renin expression in response to inhibition of ANG II production with ACE inhitor captopril, indicating an important role for COX-2 in regulation of renin. positive regulation of renin secretion into blood stream GO:1900135 macula densa UBERON:0002335 Y Y ECO:0000006 PubMed:11181406 PENTACON From primary source: PubMed:12093889;inducible:captopril AAP 4/21/2014 3 3300005569 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In control mice (mixed B6/129 background), there was sparse immunoreactive COX-2 expression in macula densa cells and surrounding cTALH. Treatment with the ACE inhibitor captopril increased expression of macula densa COX-2 expression, similar to that seen in rats. In control +/- mice, renal cortical COX-2 expression was less than in +/+ mice, and captopril also induced COX-2. Treatment with captopril increased renal renin mRNA expression in +/+ mice and plasma renin activity. COX-2 KO mice failed to increase renin expression in response to inhibition of ANG II production with ACE inhitor captopril, indicating an important role for COX-2 in regulation of renin. positive regulation of renin secretion into blood stream GO:1900135 Henles loop BTO:0004608 Y Y ECO:0000006 PubMed:11181406 PENTACON From primary source: PubMed:12093889;inducible:captopril;UBERON term is more specific than BTO term AAP 4/21/2014 3 3300005570 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In control mice (mixed B6/129 background), there was sparse immunoreactive COX-2 expression in macula densa cells and surrounding cTALH. Treatment with the ACE inhibitor captopril increased expression of macula densa COX-2 expression, similar to that seen in rats. In control +/- mice, renal cortical COX-2 expression was less than in +/+ mice, and captopril also induced COX-2. Treatment with captopril increased renal renin mRNA expression in +/+ mice and plasma renin activity. COX-2 KO mice failed to increase renin expression in response to inhibition of ANG II production with ACE inhitor captopril, indicating an important role for COX-2 in regulation of renin. positive regulation of renin secretion into blood stream GO:1900135 thick ascending limb of loop of Henle UBERON:0001291 Y Y ECO:0000006 PubMed:11181406 PENTACON From primary source: PubMed:12093889;inducible:captopril;UBERON term is more specific than BTO term AAP 4/21/2014 3 3300005571 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Angiotensin II infusion reduced medullary blood flow in COX2 deficient (-/-) female mice and WT female mice (C57BL/6J) treated with the COX-2 inhibitor SC58236 suggesting synthesis of COX2 dependent vasodilators in renal medulla. COX2 inhibition or gene disruption completely blocked the angiotensin II-induced increase in renal medullary PGE2 and PGI2 metabolite 6-keto-PGF1alpha. Treatment with COX2 inhibitor also decrease urine flow and enhanced the pressor effect of angiontensin II. COX2 was present in renal medullary interstitial cells and macula densa. negative regulation of blood pressure GO:0045776 kidney medulla interstitial cell CL:1000682 Y Y ECO:0000006 PubMed:12093889 PENTACON From review: PubMed:20059330; From review: 17003913 No cell term in BRENDA. Closest term is renal medulla. AAP 4/21/2014 3 3300005572 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Angiotensin II infusion reduced medullary blood flow in COX2 deficient (-/-) female mice and WT female mice (C57BL/6J) treated with the COX-2 inhibitor SC58236 suggesting synthesis of COX2 dependent vasodilators in renal medulla. COX2 inhibition or gene disruption completely blocked the angiotensin II-induced increase in renal medullary PGE2 and PGI2 metabolite 6-keto-PGF1alpha. Treatment with COX2 inhibitor also decrease urine flow and enhanced the pressor effect of angiontensin II. COX2 was present in renal medullary interstitial cells and macula densa. positive regulation of urine volume GO:0035810 kidney medulla interstitial cell CL:1000682 Y Y ECO:0000006 PubMed:12093889 PENTACON From review: PubMed:20059330; From review: 17003913 No cell term in BRENDA. Closest term is renal medulla. AAP 4/21/2014 3 3300005573 Faith P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity After a brief increase, the pressor effect of Ang II was abolished by COX1 deficiency (either inhibitor or knockout). COX1 was observed in renal collecting ducts. regulation of blood pressure GO:0008217 medullary collecting duct BTO:0004536 Y Y ECO:0000006 PubMed:12093889 PENTACON From review: PubMed:20059330; From review: 17003913 AAP 4/21/2014 3 3300005574 Faith P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity After a brief increase, the pressor effect of Ang II was abolished by COX1 deficiency (either inhibitor or knockout). COX1 was observed in renal collecting ducts. regulation of blood pressure GO:0008217 renal medulla collecting duct UBERON:0005185 Y Y ECO:0000006 PubMed:12093889 PENTACON From review: PubMed:20059330; From review: 17003913 AAP 4/21/2014 3 3300005575 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Angiotensin II infusion reduced medullary blood flow in COX2 deficient (-/-) female mice and WT female mice (C57BL/6J) treated with the COX-2 inhibitor SC58236 suggesting synthesis of COX2 dependent vasodilators in renal medulla. COX2 inhibition or gene disruption completely blocked the angiotensin II-induced increase in renal medullary PGE2 and PGI2 metabolite 6-keto-PGF1alpha. Treatment with COX2 inhibitor also decrease urine flow and enhanced the pressor effect of angiontensin II. COX2 was present in renal medullary interstitial cells and macula densa. renal system process involved in regulation of systemic arterial blood pressure GO:0003071 kidney medulla interstitial cell CL:1000682 Y Y ECO:0000006 PubMed:12093889 PENTACON From review: PubMed:20059330; From review: 17003913 No cell term in BRENDA. Closest term is renal medulla. AAP 4/21/2014 3 3300005576 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Angiotensin II infusion reduced medullary blood flow in COX2 deficient (-/-) female mice and WT female mice (C57BL/6J) treated with the COX-2 inhibitor SC58236 suggesting synthesis of COX2 dependent vasodilators in renal medulla. COX2 inhibition or gene disruption completely blocked the angiotensin II-induced increase in renal medullary PGE2 and PGI2 metabolite 6-keto-PGF1alpha. Treatment with COX2 inhibitor also decrease urine flow and enhanced the pressor effect of angiontensin II. COX2 was present in renal medullary interstitial cells and macula densa. macula densa BTO:0003940 Y Y ECO:0000006 PubMed:12093889 PENTACON From review: PubMed:20059330; From review: 17003913 AAP 4/21/2014 3 3300005577 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Angiotensin II infusion reduced medullary blood flow in COX2 deficient (-/-) female mice and WT female mice (C57BL/6J) treated with the COX-2 inhibitor SC58236 suggesting synthesis of COX2 dependent vasodilators in renal medulla. COX2 inhibition or gene disruption completely blocked the angiotensin II-induced increase in renal medullary PGE2 and PGI2 metabolite 6-keto-PGF1alpha. Treatment with COX2 inhibitor also decrease urine flow and enhanced the pressor effect of angiontensin II. COX2 was present in renal medullary interstitial cells and macula densa. macula densa UBERON:0002335 Y Y ECO:0000006 PubMed:12093889 PENTACON From review: PubMed:20059330; From review: 17003913 AAP 4/21/2014 3 3300005578 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/Involvement in disease Angiotensin II infusion reduced medullary blood flow in COX2 deficient (-/-) female mice and WT female mice (C57BL/6J) treated with the COX-2 inhibitor SC58236 suggesting synthesis of COX2 dependent vasodilators in renal medulla. COX2 inhibition or gene disruption completely blocked the angiotensin II-induced increase in renal medullary PGE2 and PGI2 metabolite 6-keto-PGF1alpha. Treatment with COX2 inhibitor also decrease urine flow and enhanced the pressor effect of angiontensin II. COX2 was present in renal medullary interstitial cells and macula densa. positive regulation of blood pressure GO:0045777 kidney medulla interstitial cell CL:1000682 hypertension DOID:10763 Y Y ECO:0000006 PubMed:12093889 PENTACON From review: PubMed:20059330; From review: 17003913 No cell term in BRENDA. Closest term is renal medulla. AAP 4/21/2014 3 3300005579 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/Involvement in disease Angiotensin II infusion reduced medullary blood flow in COX2 deficient (-/-) female mice and WT female mice (C57BL/6J) treated with the COX-2 inhibitor SC58236 suggesting synthesis of COX2 dependent vasodilators in renal medulla. COX2 inhibition or gene disruption completely blocked the angiotensin II-induced increase in renal medullary PGE2 and PGI2 metabolite 6-keto-PGF1alpha. Treatment with COX2 inhibitor also decrease urine flow and enhanced the pressor effect of angiontensin II. COX2 was present in renal medullary interstitial cells and macula densa. positive regulation of blood pressure GO:0045777 kidney medulla interstitial cell CL:1000682 Hypertensive disorder SNOMEDCT:38341003 Y Y ECO:0000006 PubMed:12093889 PENTACON From review: PubMed:20059330; From review: 17003913 No cell term in BRENDA. Closest term is renal medulla. AAP 4/21/2014 3 3300005580 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/Involvement in disease Angiotensin II infusion reduced medullary blood flow in COX2 deficient (-/-) female mice and WT female mice (C57BL/6J) treated with the COX-2 inhibitor SC58236 suggesting synthesis of COX2 dependent vasodilators in renal medulla. COX2 inhibition or gene disruption completely blocked the angiotensin II-induced increase in renal medullary PGE2 and PGI2 metabolite 6-keto-PGF1alpha. Treatment with COX2 inhibitor also decrease urine flow and enhanced the pressor effect of angiontensin II. COX2 was present in renal medullary interstitial cells and macula densa. negative regulation of urine volume GO:0035811 kidney medulla interstitial cell CL:1000682 hypertension DOID:10763 Y Y ECO:0000006 PubMed:12093889 PENTACON From review: PubMed:20059330; From review: 17003913 No cell term in BRENDA. Closest term is renal medulla. AAP 4/21/2014 3 3300005581 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/Involvement in disease Angiotensin II infusion reduced medullary blood flow in COX2 deficient (-/-) female mice and WT female mice (C57BL/6J) treated with the COX-2 inhibitor SC58236 suggesting synthesis of COX2 dependent vasodilators in renal medulla. COX2 inhibition or gene disruption completely blocked the angiotensin II-induced increase in renal medullary PGE2 and PGI2 metabolite 6-keto-PGF1alpha. Treatment with COX2 inhibitor also decrease urine flow and enhanced the pressor effect of angiontensin II. COX2 was present in renal medullary interstitial cells and macula densa. negative regulation of urine volume GO:0035811 kidney medulla interstitial cell CL:1000682 Hypertensive disorder SNOMEDCT:38341003 Y Y ECO:0000006 PubMed:12093889 PENTACON From review: PubMed:20059330; From review: 17003913 No cell term in BRENDA. Closest term is renal medulla. AAP 4/21/2014 3 3300005582 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/Involvement in disease Angiotensin II infusion reduced medullary blood flow in COX2 deficient (-/-) female mice and WT female mice (C57BL/6J) treated with the COX-2 inhibitor SC58236 suggesting synthesis of COX2 dependent vasodilators in renal medulla. COX2 inhibition or gene disruption completely blocked the angiotensin II-induced increase in renal medullary PGE2 and PGI2 metabolite 6-keto-PGF1alpha. Treatment with COX2 inhibitor also decrease urine flow and enhanced the pressor effect of angiontensin II. COX2 was present in renal medullary interstitial cells and macula densa. renal system process involved in regulation of systemic arterial blood pressure GO:0003071 kidney medulla interstitial cell CL:1000682 hypertension DOID:10763 Y Y ECO:0000006 PubMed:12093889 PENTACON From review: PubMed:20059330; From review: 17003913 No cell term in BRENDA. Closest term is renal medulla. AAP 4/21/2014 3 3300005583 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/Involvement in disease Angiotensin II infusion reduced medullary blood flow in COX2 deficient (-/-) female mice and WT female mice (C57BL/6J) treated with the COX-2 inhibitor SC58236 suggesting synthesis of COX2 dependent vasodilators in renal medulla. COX2 inhibition or gene disruption completely blocked the angiotensin II-induced increase in renal medullary PGE2 and PGI2 metabolite 6-keto-PGF1alpha. Treatment with COX2 inhibitor also decrease urine flow and enhanced the pressor effect of angiontensin II. COX2 was present in renal medullary interstitial cells and macula densa. renal system process involved in regulation of systemic arterial blood pressure GO:0003071 kidney medulla interstitial cell CL:1000682 Hypertensive disorder SNOMEDCT:38341003 Y Y ECO:0000006 PubMed:12093889 PENTACON From review: PubMed:20059330; From review: 17003913 No cell term in BRENDA. Closest term is renal medulla. AAP 4/21/2014 3 3300005584 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity E2 stimulated COX-2 expression and PGI2 formation in cultured mouse aortic smooth muscle cells (MASMCs) aorta BTO:0000135 aortic smooth muscle cell CL:0002539 Y Y ECO:0000006 PubMed:15550624 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005589 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity E2 stimulated COX-2 expression and PGI2 formation in cultured mouse aortic smooth muscle cells (MASMCs) aorta UBERON:0000947 aortic smooth muscle cell CL:0002539 Y Y ECO:0000006 PubMed:15550624 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005590 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Semiquantitative RT-PCR of COX-2 revealed detectable COX-2 mRNA in both control right (RC) and left (LC) common carotid arteries of three naive WT mice carotid artery BTO:0000168 Y Y ECO:0000006 PubMed:15905461 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005591 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Semiquantitative RT-PCR of COX-2 revealed detectable COX-2 mRNA in both control right (RC) and left (LC) common carotid arteries of three naive WT mice common carotid artery plus branches UBERON:0001530 Y Y ECO:0000006 PubMed:15905461 PENTACON From review: PubMed:16395396 AAP 4/21/2014 3 3300005592 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Selective deletion of COX-2 in cardiomyocytes (mixed C57BL/6J and 129SV background) led to depressed left ventricular ejection fraction, increased left ventricular end systolic volume, and depressed heart rate. These mice had a reduced exercise capacity and lost more weight in response to exercise. Deletion of cardiomyocyte COX-2 augments interstitial and perivascular fibrosis in the heart. positive regulation of heart contraction GO:0045823 parenchyma BTO:0001539 cardiac muscle cell CL:0000746 Y Y ECO:0000006 PubMed:19376970 PENTACON From review: PubMed:20059330; GO term chosen to represent COX-2 KO depresses left ventricular ejection fraction and increases end systolic volume AAP 4/21/2014 3 3300005593 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Selective deletion of COX-2 in cardiomyocytes (mixed C57BL/6J and 129SV background) led to depressed left ventricular ejection fraction, increased left ventricular end systolic volume, and depressed heart rate. These mice had a reduced exercise capacity and lost more weight in response to exercise. Deletion of cardiomyocyte COX-2 augments interstitial and perivascular fibrosis in the heart. positive regulation of heart rate GO:0010460 parenchyma BTO:0001539 cardiac muscle cell CL:0000746 Y Y ECO:0000006 PubMed:19376970 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005594 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 is induced by IL-1beta (10 ng/mL for 3 h) in cardiomyocytes and cardiac fibroblasts. parenchyma BTO:0001539 cardiac muscle cell CL:0000746 Y Y ECO:0000006 PubMed:19376970 PENTACON From review: PubMed:20059330;inducible: IL-1beta AAP 4/21/2014 3 3300005595 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 is induced by IL-1beta (10 ng/mL for 3 h) in cardiomyocytes and cardiac fibroblasts. cardiofibroblast BTO:0003093 cardiac fibroblast CL:0002548 Y Y ECO:0000006 PubMed:19376970 PENTACON From review: PubMed:20059330;inducible: IL-1beta AAP 4/21/2014 3 3300005596 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Production of TXA2 and PGF2alpha were localized to the right atrium. The late phase of the bi-phasic response to LPS was not observed in mice lacking the PGF2alpha receptor (Ptgfr-/-). Treatment of wild type mice with the COX-2 inhibitor SC58125 suppressed the late phase of LPS-induced tachycardia. positive regulation of heart rate GO:0010460 right atrium BTO:0001703 Y Y ECO:0000006 PubMed:15834430 PENTACON From primary source: PubMed:19376970; From review: PubMed:20059330; Evidence for Heart Review Fig. 2 AAP 4/21/2014 3 3300005602 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Production of TXA2 and PGF2alpha were localized to the right atrium. The late phase of the bi-phasic response to LPS was not observed in mice lacking the PGF2alpha receptor (Ptgfr-/-). Treatment of wild type mice with the COX-2 inhibitor SC58125 suppressed the late phase of LPS-induced tachycardia. positive regulation of heart rate GO:0010460 right cardiac atrium UBERON:0002078 Y Y ECO:0000006 PubMed:15834430 PENTACON From primary source: PubMed:19376970; From review: PubMed:20059330; Evidence for Heart Review Fig. 2 AAP 4/21/2014 3 3300005603 Faith P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity COX-1 is constitutively expressed in cardiomyocytes and cardiac fibroblasts. parenchyma BTO:0001539 cardiac muscle cell CL:0000746 Y Y ECO:0000006 PubMed:19376970 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005612 Faith P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity COX-1 is constitutively expressed in cardiomyocytes and cardiac fibroblasts. cardiofibroblast BTO:0003093 cardiac fibroblast CL:0002548 Y Y ECO:0000006 PubMed:19376970 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005613 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Selective deletion of COX-2 in cardiomyocytes in mice results in mild heart failure and a predisposition to arrhythmogenesis. Thus, COX-2 has a protective effect against heart failure and displays antiarrythmic activity. positive regulation of heart contraction GO:0045823 parenchyma BTO:0001539 cardiac muscle cell CL:0000746 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005614 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Selective deletion of COX-2 in cardiomyocytes in mice results in mild heart failure and a predisposition to arrhythmogenesis. Thus, COX-2 has a protective effect against heart failure and displays antiarrythmic activity. positive regulation of heart contraction GO:0045823 cardiac muscle tissue UBERON:0001133 cardiac muscle cell CL:0000746 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005615 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Selective deletion of COX-2 in cardiomyocytes in mice results in mild heart failure and a predisposition to arrhythmogenesis. Thus, COX-2 has a protective effect against heart failure and displays antiarrythmic activity. positive regulation of heart rate GO:0010460 parenchyma BTO:0001539 cardiac muscle cell CL:0000746 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005616 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Selective deletion of COX-2 in cardiomyocytes in mice results in mild heart failure and a predisposition to arrhythmogenesis. Thus, COX-2 has a protective effect against heart failure and displays antiarrythmic activity. positive regulation of heart rate GO:0010460 cardiac muscle tissue UBERON:0001133 cardiac muscle cell CL:0000746 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005617 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cox-2 plays a cardioprotective role in cardiomyocytes through production of PGI2 and PGE2 which play a role in ischemic preconditioning and protection against oxidative injury response to oxidative stress GO:0006979 parenchyma BTO:0001539 cardiac muscle cell CL:0000746 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005618 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cox-2 plays a cardioprotective role in cardiomyocytes through production of PGI2 and PGE2 which play a role in ischemic preconditioning and protection against oxidative injury response to oxidative stress GO:0006979 cardiac muscle tissue UBERON:0001133 cardiac muscle cell CL:0000746 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005619 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cox-2 produces PGF2alpha in the fibroblasts contributing to fibrosis and arrythmia and untimately heart failure and myocardial infarction cardiofibroblast BTO:0003093 cardiac fibroblast CL:0002548 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005620 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cox-2 produces PGF2alpha in the fibroblasts contributing to fibrosis and arrythmia and untimately heart failure and myocardial infarction cardiac muscle tissue UBERON:0001133 cardiac fibroblast CL:0002548 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005621 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cox-2 produces PGF2alpha in the fibroblasts contributing to fibrosis and arrythmia and untimately heart failure and myocardial infarction cardiofibroblast BTO:0003093 cardiac fibroblast CL:0002548 myocardial infarction DOID:5844 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005622 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cox-2 produces PGF2alpha in the fibroblasts contributing to fibrosis and arrythmia and untimately heart failure and myocardial infarction cardiac muscle tissue UBERON:0001133 cardiac fibroblast CL:0002548 myocardial infarction DOID:5844 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005623 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cox-2 produces PGF2alpha in the fibroblasts contributing to fibrosis and arrythmia and untimately heart failure and myocardial infarction cardiofibroblast BTO:0003093 cardiac fibroblast CL:0002548 myocardial infarction DOID:5844 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005624 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cox-2 produces PGF2alpha in the fibroblasts contributing to fibrosis and arrythmia and untimately heart failure and myocardial infarction cardiac muscle tissue UBERON:0001133 cardiac fibroblast CL:0002548 myocardial infarction DOID:5844 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005625 Jenn Q8BWM0 96979 Ptges2 Mus musculus 10090 Comment/tissue specificity mPGES-2 mRNA levels were most abundant in the heart, with relatively lower levels in the kidney, brain and small intestine. kidney BTO:0000671 Y Y ECO:0000006 PubMed:17064959 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005676 Jenn Q8BWM0 96979 Ptges2 Mus musculus 10090 Comment/tissue specificity mPGES-2 mRNA levels were most abundant in the heart, with relatively lower levels in the kidney, brain and small intestine. kidney UBERON:0002113 Y Y ECO:0000006 PubMed:17064959 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005677 Jenn Q8BWM0 96979 Ptges2 Mus musculus 10090 Comment/tissue specificity Immunohistochemistry showed mPGES-2 highly expressed in the renal cortex and the outer stripe of the outer medulla, with significant lower levels in the inner stripe of the outer medulla and inner medulla (Fig. 6A). In the cortex and the outer medulla, mPGES-2 protein was highly expressed in the distal convoluted tubule (DCT), followed by the proximal convoluted tubule (PCT) and the thick limbs of loops of Henle. However, only very weak signals were observed in the glomeruli (Fig. 6B). In the AQP2-positive collecting ducts (CD), mPGES-2 appeared to be selectively expressed in intercalated cells (Fig. 6C). Interestingly, mPGES-2 in the collecting ducts gradually increased in expression towards the tip of the renal papilla, where several CDs merge to form ducts of Bellini (Fig. 6D). renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:17064959 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005678 Jenn Q8BWM0 96979 Ptges2 Mus musculus 10090 Comment/tissue specificity Immunohistochemistry showed mPGES-2 highly expressed in the renal cortex and the outer stripe of the outer medulla, with significant lower levels in the inner stripe of the outer medulla and inner medulla (Fig. 6A). In the cortex and the outer medulla, mPGES-2 protein was highly expressed in the distal convoluted tubule (DCT), followed by the proximal convoluted tubule (PCT) and the thick limbs of loops of Henle. However, only very weak signals were observed in the glomeruli (Fig. 6B). In the AQP2-positive collecting ducts (CD), mPGES-2 appeared to be selectively expressed in intercalated cells (Fig. 6C). Interestingly, mPGES-2 in the collecting ducts gradually increased in expression towards the tip of the renal papilla, where several CDs merge to form ducts of Bellini (Fig. 6D). cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:17064959 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005679 Jenn Q8BWM0 96979 Ptges2 Mus musculus 10090 Comment/tissue specificity Immunohistochemistry showed mPGES-2 highly expressed in the renal cortex and the outer stripe of the outer medulla, with significant lower levels in the inner stripe of the outer medulla and inner medulla (Fig. 6A). In the cortex and the outer medulla, mPGES-2 protein was highly expressed in the distal convoluted tubule (DCT), followed by the proximal convoluted tubule (PCT) and the thick limbs of loops of Henle. However, only very weak signals were observed in the glomeruli (Fig. 6B). In the AQP2-positive collecting ducts (CD), mPGES-2 appeared to be selectively expressed in intercalated cells (Fig. 6C). Interestingly, mPGES-2 in the collecting ducts gradually increased in expression towards the tip of the renal papilla, where several CDs merge to form ducts of Bellini (Fig. 6D). renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:17064959 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005680 Jenn Q8BWM0 96979 Ptges2 Mus musculus 10090 Comment/tissue specificity Immunohistochemistry showed mPGES-2 highly expressed in the renal cortex and the outer stripe of the outer medulla, with significant lower levels in the inner stripe of the outer medulla and inner medulla (Fig. 6A). In the cortex and the outer medulla, mPGES-2 protein was highly expressed in the distal convoluted tubule (DCT), followed by the proximal convoluted tubule (PCT) and the thick limbs of loops of Henle. However, only very weak signals were observed in the glomeruli (Fig. 6B). In the AQP2-positive collecting ducts (CD), mPGES-2 appeared to be selectively expressed in intercalated cells (Fig. 6C). Interestingly, mPGES-2 in the collecting ducts gradually increased in expression towards the tip of the renal papilla, where several CDs merge to form ducts of Bellini (Fig. 6D). renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:17064959 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005681 Jenn Q8BWM0 96979 Ptges2 Mus musculus 10090 Comment/tissue specificity Immunohistochemistry showed mPGES-2 highly expressed in the renal cortex and the outer stripe of the outer medulla, with significant lower levels in the inner stripe of the outer medulla and inner medulla (Fig. 6A). In the cortex and the outer medulla, mPGES-2 protein was highly expressed in the distal convoluted tubule (DCT), followed by the proximal convoluted tubule (PCT) and the thick limbs of loops of Henle. However, only very weak signals were observed in the glomeruli (Fig. 6B). In the AQP2-positive collecting ducts (CD), mPGES-2 appeared to be selectively expressed in intercalated cells (Fig. 6C). Interestingly, mPGES-2 in the collecting ducts gradually increased in expression towards the tip of the renal papilla, where several CDs merge to form ducts of Bellini (Fig. 6D). renal distal tubule BTO:0000482 Y Y ECO:0000006 PubMed:17064959 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005682 Jenn Q8BWM0 96979 Ptges2 Mus musculus 10090 Comment/tissue specificity Immunohistochemistry showed mPGES-2 highly expressed in the renal cortex and the outer stripe of the outer medulla, with significant lower levels in the inner stripe of the outer medulla and inner medulla (Fig. 6A). In the cortex and the outer medulla, mPGES-2 protein was highly expressed in the distal convoluted tubule (DCT), followed by the proximal convoluted tubule (PCT) and the thick limbs of loops of Henle. However, only very weak signals were observed in the glomeruli (Fig. 6B). In the AQP2-positive collecting ducts (CD), mPGES-2 appeared to be selectively expressed in intercalated cells (Fig. 6C). Interestingly, mPGES-2 in the collecting ducts gradually increased in expression towards the tip of the renal papilla, where several CDs merge to form ducts of Bellini (Fig. 6D). renal convoluted tubule UBERON:0006534 Y Y ECO:0000006 PubMed:17064959 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005683 Jenn Q8BWM0 96979 Ptges2 Mus musculus 10090 Comment/tissue specificity Immunohistochemistry showed mPGES-2 highly expressed in the renal cortex and the outer stripe of the outer medulla, with significant lower levels in the inner stripe of the outer medulla and inner medulla (Fig. 6A). In the cortex and the outer medulla, mPGES-2 protein was highly expressed in the distal convoluted tubule (DCT), followed by the proximal convoluted tubule (PCT) and the thick limbs of loops of Henle. However, only very weak signals were observed in the glomeruli (Fig. 6B). In the AQP2-positive collecting ducts (CD), mPGES-2 appeared to be selectively expressed in intercalated cells (Fig. 6C). Interestingly, mPGES-2 in the collecting ducts gradually increased in expression towards the tip of the renal papilla, where several CDs merge to form ducts of Bellini (Fig. 6D). renal proximal tubule BTO:0001498 Y Y ECO:0000006 PubMed:17064959 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005684 Jenn Q9R0Q7 56351 Ptges3 Mus musculus 10090 Comment/tissue specificity RT-PCR shows expression in mouse kidney and IMCD-3 cells. n situ hybridization was used to examine the distribution of cPGES mRNA in mouse kidneys. As shown in Fig. 5A, cPGES was ubiquitously expressed in the kidney with slightly higher expression in the medulla kidney BTO:0000671 Y Y ECO:0000006 PubMed:14563409 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005685 Jenn Q9R0Q7 56351 Ptges3 Mus musculus 10090 Comment/tissue specificity RT-PCR shows expression in mouse kidney and IMCD-3 cells. n situ hybridization was used to examine the distribution of cPGES mRNA in mouse kidneys. As shown in Fig. 5A, cPGES was ubiquitously expressed in the kidney with slightly higher expression in the medulla kidney UBERON:0002113 Y Y ECO:0000006 PubMed:14563409 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005686 Jenn Q9R0Q7 56351 Ptges3 Mus musculus 10090 Comment/tissue specificity RT-PCR shows expression in mouse kidney and IMCD-3 cells inner medullary collecting duct cell BTO:0004543 Y Y ECO:0000006 PubMed:14563409 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005687 Jenn P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity Within the kidney, EP1 mRNA has been mapped by in situ hybridization and is expressed primarily in the collecting duct, with levels increasing from the cortex to the papillae; EP1 receptor may also be present in glomerular mesangial cells collecting duct BTO:0000761 Y Y ECO:0000033 PubMed:11181968 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005688 Jenn P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity Within the kidney, EP1 mRNA has been mapped by in situ hybridization and is expressed primarily in the collecting duct, with levels increasing from the cortex to the papillae; EP1 receptor may also be present in glomerular mesangial cells collecting duct of renal tubule UBERON:0001232 Y Y ECO:0000033 PubMed:11181968 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005689 Jenn P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity Within the kidney, EP1 mRNA has been mapped by in situ hybridization and is expressed primarily in the collecting duct, with levels increasing from the cortex to the papillae; EP1 receptor may also be present in glomerular mesangial cells renal glomerulus BTO:0000530 glomerular mesangial cell CL:1000742 Y Y ECO:0000033 PubMed:11181968 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005690 Jenn P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity Within the kidney, EP1 mRNA has been mapped by in situ hybridization and is expressed primarily in the collecting duct, with levels increasing from the cortex to the papillae; EP1 receptor may also be present in glomerular mesangial cells renal glomerulus UBERON:0000074 glomerular mesangial cell CL:1000742 Y Y ECO:0000033 PubMed:11181968 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005691 Jenn P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity In the kidney, in situ hybridization has demonstrated that EP3 receptor mRNA is abundant in the thick ascending limb (TAL) and collecting duct collecting duct BTO:0000761 Y Y ECO:0000033 PubMed:11181968 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005692 Jenn P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity In the kidney, in situ hybridization has demonstrated that EP3 receptor mRNA is abundant in the thick ascending limb (TAL) and collecting duct collecting duct of renal tubule UBERON:0001232 Y Y ECO:0000033 PubMed:11181968 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005693 Jenn P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity In the kidney, in situ hybridization has demonstrated that EP3 receptor mRNA is abundant in the thick ascending limb (TAL) and collecting duct Henles loop BTO:0004608 Y Y ECO:0000033 PubMed:11181968 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005694 Jenn P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity In the kidney, in situ hybridization has demonstrated that EP3 receptor mRNA is abundant in the thick ascending limb (TAL) and collecting duct thick ascending limb of loop of Henle UBERON:0001291 Y Y ECO:0000033 PubMed:11181968 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005695 Jenn Q62053 19217 Ptger2 Mus musculus 10090 Comment/tissue specificity Although only low levels of EP2 receptor mRNA are detected in the kidney and its precise intrarenal localization is uncertain, mice with targeted disruption of the EP2 receptor exhibit salt-sensitive hypertension, suggesting that this receptor may play an important role in salt excretion. kidney BTO:0000671 Y Y ECO:0000033 PubMed:11181968 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005696 Jenn Q62053 19217 Ptger2 Mus musculus 10090 Comment/tissue specificity Although only low levels of EP2 receptor mRNA are detected in the kidney and its precise intrarenal localization is uncertain, mice with targeted disruption of the EP2 receptor exhibit salt-sensitive hypertension, suggesting that this receptor may play an important role in salt excretion. kidney UBERON:0002113 Y Y ECO:0000033 PubMed:11181968 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005697 Jenn P32240 19219 Ptger4 Mus musculus 10090 Comment/tissue specificity EP4 receptor mRNA is predominantly expressed in the glomerulus, where it may contribute to the regulation of glomerular hemodynamics and renin release renal glomerulus BTO:0000530 Y Y ECO:0000033 PubMed:17361113 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005698 Jenn P32240 19219 Ptger4 Mus musculus 10090 Comment/tissue specificity EP4 receptor mRNA is predominantly expressed in the glomerulus, where it may contribute to the regulation of glomerular hemodynamics and renin release renal glomerulus UBERON:0000074 Y Y ECO:0000033 PubMed:17361113 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005699 Jenn P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity The IP receptor mRNA is highly expressed in the afferent arteriole, where it may also dilate renal arterioles and stimulate renin release renal artery BTO:0001165 Y Y ECO:0000033 PubMed:17361113 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005700 Jenn P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity The IP receptor mRNA is highly expressed in the afferent arteriole, where it may also dilate renal arterioles and stimulate renin release afferent arteriole UBERON:0004639 Y Y ECO:0000033 PubMed:17361113 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005701 Jenn P30987 21390 Tbxa2r Mus musculus 10090 Comment/tissue specificity TP receptor in the glomerulus may counteract the effects of these dilator prostanoids and increase glomerular resistance. renal glomerulus BTO:0000530 Y Y ECO:0000033 PubMed:17361113 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005702 Jenn P30987 21390 Tbxa2r Mus musculus 10090 Comment/tissue specificity TP receptor in the glomerulus may counteract the effects of these dilator prostanoids and increase glomerular resistance. renal glomerulus UBERON:0000074 Y Y ECO:0000033 PubMed:17361113 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005703 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In contrast to renal medullary COX2, renal cortical COX2 activity is associated with renin release, and increases blood pressure positive regulation of renin secretion into blood stream GO:1900135 renal cortex BTO:0001166 Y Y ECO:0000033 PubMed:17361113 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005704 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In contrast to renal medullary COX2, renal cortical COX2 activity is associated with renin release, and increases blood pressure positive regulation of renin secretion into blood stream GO:1900135 cortex of kidney UBERON:0001225 Y Y ECO:0000033 PubMed:17361113 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005705 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In contrast to renal medullary COX2, renal cortical COX2 activity is associated with renin release, and increases blood pressure positive regulation of blood pressure GO:0045777 renal cortex BTO:0001166 Y Y ECO:0000033 PubMed:17361113 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005706 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In contrast to renal medullary COX2, renal cortical COX2 activity is associated with renin release, and increases blood pressure positive regulation of blood pressure GO:0045777 cortex of kidney UBERON:0001225 Y Y ECO:0000033 PubMed:17361113 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005707 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity In STZ mouse cortex, both COX-1 and COX-2 are increased 3.6- and 3-fold renal cortex BTO:0001166 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005718 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity In STZ mouse cortex, both COX-1 and COX-2 are increased 3.6- and 3-fold cortex of kidney UBERON:0001225 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005719 Jenn/Faith P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity In STZ mouse cortex, both COX-1 and COX-2 are increased 3.6- and 3-fold renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005720 Jenn/Faith P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity In STZ mouse cortex, both COX-1 and COX-2 are increased 3.6- and 3-fold cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005721 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In STZ mouse cortex, both COX-1 and COX-2 are increased 3.6- and 3-fold renal cortex BTO:0001166 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005722 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In STZ mouse cortex, both COX-1 and COX-2 are increased 3.6- and 3-fold cortex of kidney UBERON:0001225 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005723 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In STZ mouse cortex, both COX-1 and COX-2 are increased 3.6- and 3-fold renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005724 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In STZ mouse cortex, both COX-1 and COX-2 are increased 3.6- and 3-fold cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005725 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity In the medulla, COX-1 is unchanged in the STZ mice, however, COX-2 increases 2- and 2.75-fold in STZ renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005726 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity In the medulla, COX-1 is unchanged in the STZ mice, however, COX-2 increases 2- and 2.75-fold in STZ renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005727 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In the medulla, COX-1 is unchanged in the STZ mice, however, COX-2 increases 2- and 2.75-fold in STZ renal medulla BTO:0001167 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005728 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In the medulla, COX-1 is unchanged in the STZ mice, however, COX-2 increases 2- and 2.75-fold in STZ renal medulla UBERON:0000362 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005729 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In the medulla, COX-1 is unchanged in the STZ mice, however, COX-2 increases 2- and 2.75-fold in STZ renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005730 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In the medulla, COX-1 is unchanged in the STZ mice, however, COX-2 increases 2- and 2.75-fold in STZ renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005731 Jenn P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity there is an increase in cortical EP1 and EP3 receptors in STZ mice. Conversely, EP4 receptors are diminished renal cortex BTO:0001166 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005732 Jenn P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity there is an increase in cortical EP1 and EP3 receptors in STZ mice. Conversely, EP4 receptors are diminished cortex of kidney UBERON:0001225 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005733 Jenn P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity there is an increase in cortical EP1 and EP3 receptors in STZ mice. Conversely, EP4 receptors are diminished renal cortex BTO:0001166 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005734 Jenn P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity there is an increase in cortical EP1 and EP3 receptors in STZ mice. Conversely, EP4 receptors are diminished cortex of kidney UBERON:0001225 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005735 Jenn P32240 19219 Ptger4 Mus musculus 10090 Comment/tissue specificity there is an increase in cortical EP1 and EP3 receptors in STZ mice. Conversely, EP4 receptors are diminished renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005736 Jenn P32240 19219 Ptger4 Mus musculus 10090 Comment/tissue specificity there is an increase in cortical EP1 and EP3 receptors in STZ mice. Conversely, EP4 receptors are diminished cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005737 Jenn P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity medullary EP1 receptors are diminished in STZ mice, while EP3 receptors are increased 3.6-fold renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005738 Jenn P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity medullary EP1 receptors are diminished in STZ mice, while EP3 receptors are increased 3.6-fold renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005739 Jenn P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity medullary EP1 receptors are diminished in STZ mice, while EP3 receptors are increased 3.6-fold renal medulla BTO:0001167 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005740 Jenn P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity medullary EP1 receptors are diminished in STZ mice, while EP3 receptors are increased 3.6-fold renal medulla UBERON:0000362 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005741 Jenn/Faith P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity medullary EP1 receptors are diminished in STZ mice, while EP3 receptors are increased 3.6-fold renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005742 Jenn/Faith P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity medullary EP1 receptors are diminished in STZ mice, while EP3 receptors are increased 3.6-fold renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005743 Jenn P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity in B6-Ins2Akita mice cortical EP1 receptors are increased 2.4-fold (Fig. 5A); however, the remaining EP receptor subtypes are significantly diminished 0.26-, 0.38-, and 0.47-fold for EP2, EP3, and EP4, respectively. renal cortex BTO:0001166 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005744 Jenn P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity in B6-Ins2Akita mice cortical EP1 receptors are increased 2.4-fold (Fig. 5A); however, the remaining EP receptor subtypes are significantly diminished 0.26-, 0.38-, and 0.47-fold for EP2, EP3, and EP4, respectively. cortex of kidney UBERON:0001225 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005745 Jenn/Faith P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity in B6-Ins2Akita mice cortical EP1 receptors are increased 2.4-fold (Fig. 5A); however, the remaining EP receptor subtypes are significantly diminished 0.26-, 0.38-, and 0.47-fold for EP2, EP3, and EP4, respectively. renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005746 Jenn/Faith P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity in B6-Ins2Akita mice cortical EP1 receptors are increased 2.4-fold (Fig. 5A); however, the remaining EP receptor subtypes are significantly diminished 0.26-, 0.38-, and 0.47-fold for EP2, EP3, and EP4, respectively. cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005747 Jenn P32240 19219 Ptger4 Mus musculus 10090 Comment/tissue specificity in B6-Ins2Akita mice cortical EP1 receptors are increased 2.4-fold (Fig. 5A); however, the remaining EP receptor subtypes are significantly diminished 0.26-, 0.38-, and 0.47-fold for EP2, EP3, and EP4, respectively. renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005748 Jenn P32240 19219 Ptger4 Mus musculus 10090 Comment/tissue specificity in B6-Ins2Akita mice cortical EP1 receptors are increased 2.4-fold (Fig. 5A); however, the remaining EP receptor subtypes are significantly diminished 0.26-, 0.38-, and 0.47-fold for EP2, EP3, and EP4, respectively. cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005749 Jenn P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity in B6-Ins2Akita mice cortical EP1 receptors are increased 2.4-fold (Fig. 5A); however, the remaining EP receptor subtypes are significantly diminished 0.26-, 0.38-, and 0.47-fold for EP2, EP3, and EP4, respectively. renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005750 Jenn P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity in B6-Ins2Akita mice cortical EP1 receptors are increased 2.4-fold (Fig. 5A); however, the remaining EP receptor subtypes are significantly diminished 0.26-, 0.38-, and 0.47-fold for EP2, EP3, and EP4, respectively. cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005751 Jenn Q62053 19217 Ptger2 Mus musculus 10090 Comment/tissue specificity in B6-Ins2Akita mice cortical EP1 receptors are increased 2.4-fold (Fig. 5A); however, the remaining EP receptor subtypes are significantly diminished 0.26-, 0.38-, and 0.47-fold for EP2, EP3, and EP4, respectively. renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005752 Jenn Q62053 19217 Ptger2 Mus musculus 10090 Comment/tissue specificity in B6-Ins2Akita mice cortical EP1 receptors are increased 2.4-fold (Fig. 5A); however, the remaining EP receptor subtypes are significantly diminished 0.26-, 0.38-, and 0.47-fold for EP2, EP3, and EP4, respectively. cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005753 Jenn P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity In the medullary region of B6-Ins2Akita mice (Fig. 5B), both EP1 and EP3 are increased 5.5- and 1.95-fold, respectively, but EP2 and EP4 are unchanged. renal medulla BTO:0001167 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005754 Jenn P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity In the medullary region of B6-Ins2Akita mice (Fig. 5B), both EP1 and EP3 are increased 5.5- and 1.95-fold, respectively, but EP2 and EP4 are unchanged. renal medulla UBERON:0000362 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005755 Jenn/Faith P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity In the medullary region of B6-Ins2Akita mice (Fig. 5B), both EP1 and EP3 are increased 5.5- and 1.95-fold, respectively, but EP2 and EP4 are unchanged. renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005756 Jenn/Faith P35375 19216 Ptger1 Mus musculus 10090 Comment/tissue specificity In the medullary region of B6-Ins2Akita mice (Fig. 5B), both EP1 and EP3 are increased 5.5- and 1.95-fold, respectively, but EP2 and EP4 are unchanged. renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005757 Jenn P32240 19219 Ptger4 Mus musculus 10090 Comment/tissue specificity In the medullary region of B6-Ins2Akita mice (Fig. 5B), both EP1 and EP3 are increased 5.5- and 1.95-fold, respectively, but EP2 and EP4 are unchanged. renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005758 Jenn P32240 19219 Ptger4 Mus musculus 10090 Comment/tissue specificity In the medullary region of B6-Ins2Akita mice (Fig. 5B), both EP1 and EP3 are increased 5.5- and 1.95-fold, respectively, but EP2 and EP4 are unchanged. renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005759 Jenn P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity In the medullary region of B6-Ins2Akita mice (Fig. 5B), both EP1 and EP3 are increased 5.5- and 1.95-fold, respectively, but EP2 and EP4 are unchanged. renal medulla BTO:0001167 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005760 Jenn P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity In the medullary region of B6-Ins2Akita mice (Fig. 5B), both EP1 and EP3 are increased 5.5- and 1.95-fold, respectively, but EP2 and EP4 are unchanged. renal medulla UBERON:0000362 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005761 Jenn/Faith P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity In the medullary region of B6-Ins2Akita mice (Fig. 5B), both EP1 and EP3 are increased 5.5- and 1.95-fold, respectively, but EP2 and EP4 are unchanged. renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005762 Jenn/Faith P30557 19218 Ptger3 Mus musculus 10090 Comment/tissue specificity In the medullary region of B6-Ins2Akita mice (Fig. 5B), both EP1 and EP3 are increased 5.5- and 1.95-fold, respectively, but EP2 and EP4 are unchanged. renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005763 Jenn Q62053 19217 Ptger2 Mus musculus 10090 Comment/tissue specificity In the medullary region of B6-Ins2Akita mice (Fig. 5B), both EP1 and EP3 are increased 5.5- and 1.95-fold, respectively, but EP2 and EP4 are unchanged. renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005764 Jenn Q62053 19217 Ptger2 Mus musculus 10090 Comment/tissue specificity In the medullary region of B6-Ins2Akita mice (Fig. 5B), both EP1 and EP3 are increased 5.5- and 1.95-fold, respectively, but EP2 and EP4 are unchanged. renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005765 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity In B6-Ins2Akita mice, a 2-fold increase is only seen for COX-1 in the renal cortex while COX-2 levels remain unchanged renal cortex BTO:0001166 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005766 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity In B6-Ins2Akita mice, a 2-fold increase is only seen for COX-1 in the renal cortex while COX-2 levels remain unchanged cortex of kidney UBERON:0001225 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005767 Jenn/Faith P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity In B6-Ins2Akita mice, a 2-fold increase is only seen for COX-1 in the renal cortex while COX-2 levels remain unchanged renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005768 Jenn/Faith P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity In B6-Ins2Akita mice, a 2-fold increase is only seen for COX-1 in the renal cortex while COX-2 levels remain unchanged cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005769 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In B6-Ins2Akita mice, a 2-fold increase is only seen for COX-1 in the renal cortex while COX-2 levels remain unchanged renal cortex BTO:0001166 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005770 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity In B6-Ins2Akita mice, a 2-fold increase is only seen for COX-1 in the renal cortex while COX-2 levels remain unchanged cortex of kidney UBERON:0001225 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005771 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity n the medulla, COX-1 is decreased to 0.14-fold of control in B6-Ins2Akita mice; however, COX-2 increases 2.75-fold in B6-Ins2Akita mice. renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005772 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity n the medulla, COX-1 is decreased to 0.14-fold of control in B6-Ins2Akita mice; however, COX-2 increases 2.75-fold in B6-Ins2Akita mice. renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005773 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity n the medulla, COX-1 is decreased to 0.14-fold of control in B6-Ins2Akita mice; however, COX-2 increases 2.75-fold in B6-Ins2Akita mice. renal medulla BTO:0001167 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005774 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity n the medulla, COX-1 is decreased to 0.14-fold of control in B6-Ins2Akita mice; however, COX-2 increases 2.75-fold in B6-Ins2Akita mice. renal medulla UBERON:0000362 type 1 diabetes mellitus DOID:9744 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005775 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity n the medulla, COX-1 is decreased to 0.14-fold of control in B6-Ins2Akita mice; however, COX-2 increases 2.75-fold in B6-Ins2Akita mice. renal medulla BTO:0001167 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005776 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity n the medulla, COX-1 is decreased to 0.14-fold of control in B6-Ins2Akita mice; however, COX-2 increases 2.75-fold in B6-Ins2Akita mice. renal medulla UBERON:0000362 Y Y ECO:0000006 PubMed:16954344 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300005777 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Both COXs are expressed in renal tissue; COX-1 mainly in the cortical and medullary collecting ducts, mesangial cells, arteriolar endothelium, and the epithelium of Bowman's capsule and COX-2 in medullary interstitial cells, the macula densa, and the cortical thick ascending limb. renal medulla BTO:0001167 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005808 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Both COXs are expressed in renal tissue; COX-1 mainly in the cortical and medullary collecting ducts, mesangial cells, arteriolar endothelium, and the epithelium of Bowman's capsule and COX-2 in medullary interstitial cells, the macula densa, and the cortical thick ascending limb. renal medulla UBERON:0000362 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005809 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Both COXs are expressed in renal tissue; COX-1 mainly in the cortical and medullary collecting ducts, mesangial cells, arteriolar endothelium, and the epithelium of Bowman's capsule and COX-2 in medullary interstitial cells, the macula densa, and the cortical thick ascending limb. macula densa BTO:0003940 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005810 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Both COXs are expressed in renal tissue; COX-1 mainly in the cortical and medullary collecting ducts, mesangial cells, arteriolar endothelium, and the epithelium of Bowman's capsule and COX-2 in medullary interstitial cells, the macula densa, and the cortical thick ascending limb. macula densa UBERON:0002335 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005811 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Both COXs are expressed in renal tissue; COX-1 mainly in the cortical and medullary collecting ducts, mesangial cells, arteriolar endothelium, and the epithelium of Bowman's capsule and COX-2 in medullary interstitial cells, the macula densa, and the cortical thick ascending limb. Henles loop BTO:0004608 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005812 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Both COXs are expressed in renal tissue; COX-1 mainly in the cortical and medullary collecting ducts, mesangial cells, arteriolar endothelium, and the epithelium of Bowman's capsule and COX-2 in medullary interstitial cells, the macula densa, and the cortical thick ascending limb. thick ascending limb of loop of Henle UBERON:0001291 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005813 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity Both COXs are expressed in renal tissue; COX-1 mainly in the cortical and medullary collecting ducts, mesangial cells, arteriolar endothelium, and the epithelium of Bowman's capsule and COX-2 in medullary interstitial cells, the macula densa, and the cortical thick ascending limb. collecting duct BTO:0000761 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005814 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity Both COXs are expressed in renal tissue; COX-1 mainly in the cortical and medullary collecting ducts, mesangial cells, arteriolar endothelium, and the epithelium of Bowman's capsule and COX-2 in medullary interstitial cells, the macula densa, and the cortical thick ascending limb. collecting duct of renal tubule UBERON:0001232 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005815 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity Both COXs are expressed in renal tissue; COX-1 mainly in the cortical and medullary collecting ducts, mesangial cells, arteriolar endothelium, and the epithelium of Bowman's capsule and COX-2 in medullary interstitial cells, the macula densa, and the cortical thick ascending limb. renal glomerular capsule BTO:0002297 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005816 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity Both COXs are expressed in renal tissue; COX-1 mainly in the cortical and medullary collecting ducts, mesangial cells, arteriolar endothelium, and the epithelium of Bowman's capsule and COX-2 in medullary interstitial cells, the macula densa, and the cortical thick ascending limb. glomerular capsule UBERON:0001230 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005817 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity Both COXs are expressed in renal tissue; COX-1 mainly in the cortical and medullary collecting ducts, mesangial cells, arteriolar endothelium, and the epithelium of Bowman's capsule and COX-2 in medullary interstitial cells, the macula densa, and the cortical thick ascending limb. mesangium BTO:0002494 mesangial cell CL:0000650 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005818 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity Both COXs are expressed in renal tissue; COX-1 mainly in the cortical and medullary collecting ducts, mesangial cells, arteriolar endothelium, and the epithelium of Bowman's capsule and COX-2 in medullary interstitial cells, the macula densa, and the cortical thick ascending limb. mesangium UBERON:0002319 mesangial cell CL:0000650 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005819 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cortical COX-2 expression is increased by low dietary salt intake, which, through the action of PGE2, and possibly PGI2, increases renin release, leading to sodium retention and elevated blood pressure. Concordantly, COX-2 inhibition or disruption decreases plasma renin following administration of a low-salt diet positive regulation of renin secretion into blood stream GO:1900135 renal cortex BTO:0001166 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005820 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cortical COX-2 expression is increased by low dietary salt intake, which, through the action of PGE2, and possibly PGI2, increases renin release, leading to sodium retention and elevated blood pressure. Concordantly, COX-2 inhibition or disruption decreases plasma renin following administration of a low-salt diet positive regulation of renin secretion into blood stream GO:1900135 cortex of kidney UBERON:0001225 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005821 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cortical COX-2 expression is increased by low dietary salt intake, which, through the action of PGE2, and possibly PGI2, increases renin release, leading to sodium retention and elevated blood pressure. Concordantly, COX-2 inhibition or disruption decreases plasma renin following administration of a low-salt diet renal sodium excretion GO:0035812 renal cortex BTO:0001166 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005822 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cortical COX-2 expression is increased by low dietary salt intake, which, through the action of PGE2, and possibly PGI2, increases renin release, leading to sodium retention and elevated blood pressure. Concordantly, COX-2 inhibition or disruption decreases plasma renin following administration of a low-salt diet renal sodium excretion GO:0035812 cortex of kidney UBERON:0001225 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005823 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cortical COX-2 expression is increased by low dietary salt intake, which, through the action of PGE2, and possibly PGI2, increases renin release, leading to sodium retention and elevated blood pressure. Concordantly, COX-2 inhibition or disruption decreases plasma renin following administration of a low-salt diet positive regulation of blood pressure GO:0045777 renal cortex BTO:0001166 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005824 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cortical COX-2 expression is increased by low dietary salt intake, which, through the action of PGE2, and possibly PGI2, increases renin release, leading to sodium retention and elevated blood pressure. Concordantly, COX-2 inhibition or disruption decreases plasma renin following administration of a low-salt diet positive regulation of blood pressure GO:0045777 cortex of kidney UBERON:0001225 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005825 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity COX-2 mRNA was increased markedly in the presence of atherosclerosis, whereas COX-1 mRNA was not increased significantly in murine atherosclerotic aortas aorta BTO:0000135 Y Y ECO:0000006 PubMed:11248083 PENTACON From review: PubMed:21508345 AAP 4/21/2014 3 3300005844 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity COX-2 mRNA was increased markedly in the presence of atherosclerosis, whereas COX-1 mRNA was not increased significantly in murine atherosclerotic aortas aorta UBERON:0000947 Y Y ECO:0000006 PubMed:11248083 PENTACON From review: PubMed:21508345 AAP 4/21/2014 3 3300005845 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 mRNA was increased markedly in the presence of atherosclerosis, whereas COX-1 mRNA was not increased significantly in murine atherosclerotic aortas aorta BTO:0000135 aortic atherosclerosis DOID:10230 Y Y ECO:0000006 PubMed:11248083 PENTACON From review: PubMed:21508345 AAP 4/21/2014 3 3300005846 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 mRNA was increased markedly in the presence of atherosclerosis, whereas COX-1 mRNA was not increased significantly in murine atherosclerotic aortas aorta UBERON:0000947 aortic atherosclerosis DOID:10230 Y Y ECO:0000006 PubMed:11248083 PENTACON From review: PubMed:21508345 AAP 4/21/2014 3 3300005847 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 mRNA was increased markedly in the presence of atherosclerosis, whereas COX-1 mRNA was not increased significantly in murine atherosclerotic aortas aorta BTO:0000135 Y Y ECO:0000006 PubMed:11248083 PENTACON From review: PubMed:21508345 AAP 4/21/2014 3 3300005848 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 mRNA was increased markedly in the presence of atherosclerosis, whereas COX-1 mRNA was not increased significantly in murine atherosclerotic aortas aorta UBERON:0000947 Y Y ECO:0000006 PubMed:11248083 PENTACON From review: PubMed:21508345 AAP 4/21/2014 3 3300005849 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Nuclear run-on, Northern blot, and COX-2 RT-PCR analysis of mCOX-2 gene expression in LPS-stimulated RAW264.7 cells RAW-264.7 cell BTO:0003292 macrophage CL:0000235 lipopolysaccharide CHEBI:16412 Y Y ECO:0000006 PubMed:17114486 PENTACON From review: PubMed:21942677 AAP 4/21/2014 3 3300005850 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity PTGS1 and PTGS2 expression is induced in response to serum in NIH-3T3 cells NIH-3T3 cell BTO:0000944 fibroblast CL:0000057 Y Y ECO:0000006 PubMed: 8215426 PENTACON From review: PubMed:21942677 AAP 4/21/2014 3 3300005851 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity PTGS1 and PTGS2 expression is induced in response to serum in NIH-3T3 cells NIH-3T3 cell BTO:0000944 fibroblast CL:0000057 Y Y ECO:0000006 PubMed: 8215426 PENTACON From review: PubMed:21942677 AAP 4/21/2014 3 3300005852 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity PDGF induces PTGS2 expression in NIH-3T3 cells NIH-3T3 cell BTO:0000944 fibroblast CL:0000057 Y Y ECO:0000006 PubMed:8940199 PENTACON From review: PubMed:21942677; inducible by PDGF AAP 4/21/2014 3 3300005853 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity Cox1-/- and Cox2-/- mice show decreased incidence of arthritis in response to collagen injection arthritis DOID:848 Y Y ECO:0000006 PubMed:11145026 PENTACON From review: PubMed:18834304 AAP 4/21/2014 3 3300005854 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cox1-/- and Cox2-/- mice show decreased incidence of arthritis in response to collagen injection arthritis DOID:848 Y Y ECO:0000006 PubMed:11145026 PENTACON From review: PubMed:18834304 AAP 4/21/2014 3 3300005855 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity All of the macrophages ultimately respond to TLR-4 stimulation by greatly up-regulating COX-2 and mPGES-1 and down-regulating 5-LOX (data not shown) from a transcriptomic standpoint. RAW-264.7 cell BTO:0003292 macrophage CL:0000235 Y Y ECO:0000006 PubMed:21653236 PENTACON From review: PubMed:22155285 AAP 4/21/2014 3 3300005856 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity All of the macrophages ultimately respond to TLR-4 stimulation by greatly up-regulating COX-2 and mPGES-1 and down-regulating 5-LOX (data not shown) from a transcriptomic standpoint. peritoneal macrophage BTO:0001034 peritoneal macrophage CL:0000581 Y Y ECO:0000006 PubMed:21653236 PENTACON From review: PubMed:22155285 AAP 4/21/2014 3 3300005857 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity All of the macrophages ultimately respond to TLR-4 stimulation by greatly up-regulating COX-2 and mPGES-1 and down-regulating 5-LOX (data not shown) from a transcriptomic standpoint. peritoneum UBERON:0002358 peritoneal macrophage CL:0000581 Y Y ECO:0000006 PubMed:21653236 PENTACON From review: PubMed:22155285 AAP 4/21/2014 3 3300005858 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity All of the macrophages ultimately respond to TLR-4 stimulation by greatly up-regulating COX-2 and mPGES-1 and down-regulating 5-LOX (data not shown) from a transcriptomic standpoint. macrophage BTO:0000801 macrophage CL:0000235 Y Y ECO:0000006 PubMed:21653236 PENTACON From review: PubMed:22155285; thioglycollate-elicited macrophage AAP 4/21/2014 3 3300005859 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity All of the macrophages ultimately respond to TLR-4 stimulation by greatly up-regulating COX-2 and mPGES-1 and down-regulating 5-LOX (data not shown) from a transcriptomic standpoint. bone marrow-derived macrophage BTO:0004732 bone marrow macrophage CL:0002476 Y Y ECO:0000006 PubMed:21653236 PENTACON From review: PubMed:22155285; thioglycollate-elicited macrophage AAP 4/21/2014 3 3300005860 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity All of the macrophages ultimately respond to TLR-4 stimulation by greatly up-regulating COX-2 and mPGES-1 and down-regulating 5-LOX (data not shown) from a transcriptomic standpoint. bone marrow UBERON:0002371 bone marrow macrophage CL:0002476 Y Y ECO:0000006 PubMed:21653236 PENTACON From review: PubMed:22155285; thioglycollate-elicited macrophage AAP 4/21/2014 3 3300005861 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity selective deletion of cardiomyocyte COX-2 resulted in heart failure and cardiac fibrosis in mice (unpublished observations) parenchyma BTO:0001539 cardiac muscle cell CL:0000746 Y Y ECO:0000006 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005862 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity selective deletion of cardiomyocyte COX-2 resulted in heart failure and cardiac fibrosis in mice (unpublished observations) myocardium UBERON:0002349 cardiac muscle cell CL:0000746 Y Y ECO:0000006 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005863 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Ptgs2 knockdown leads to decreased platelet counts and increased thrombosis. The thrombotic response was accelerated in mice given the PGHS-2 inhibitor DFU. negative regulation of platelet aggregation GO:0090331 vasculature BTO:0003718 Y Y ECO:0000006 PubMed:16614756 PENTACON From review: PubMed:19095631;From review: PubMed:20059330 AAP 4/21/2014 3 3300005864 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Ptgs2 knockdown leads to decreased platelet counts and increased thrombosis. The thrombotic response was accelerated in mice given the PGHS-2 inhibitor DFU. negative regulation of platelet aggregation GO:0090331 vasculature UBERON:0002049 Y Y ECO:0000006 PubMed:16614756 PENTACON From review: PubMed:19095631;From review: PubMed:20059330 AAP 4/21/2014 3 3300005865 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Ptgs2 knockdown leads to decreased platelet counts and increased thrombosis. The thrombotic response was accelerated in mice given the PGHS-2 inhibitor DFU. UKNOWN GO:1901731 vasculature BTO:0003718 cyclooxygenase 2 inhibitor CHEBI:50629 Y Y ECO:0000006 PubMed:16614756 PENTACON From review: PubMed:19095631;From review: PubMed:20059330 AAP 4/21/2014 3 3300005866 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Ptgs2 knockdown leads to decreased platelet counts and increased thrombosis. The thrombotic response was accelerated in mice given the PGHS-2 inhibitor DFU. UKNOWN GO:1901731 vasculature UBERON:0002049 cyclooxygenase 2 inhibitor CHEBI:50629 Y Y ECO:0000006 PubMed:16614756 PENTACON From review: PubMed:19095631;From review: PubMed:20059330 AAP 4/21/2014 3 3300005867 Jenn/Faith P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity PGHS-1 KD delayed the response to a thrombogenic stimulus UKNOWN GO:1901731 vasculature BTO:0003718 Y Y ECO:0000006 PubMed:16614756 PENTACON From review: PubMed:19095631;From review: PubMed:20059330 AAP 4/21/2014 3 3300005868 Jenn/Faith P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity PGHS-1 KD delayed the response to a thrombogenic stimulus UKNOWN GO:1901731 vasculature UBERON:0002049 Y Y ECO:0000006 PubMed:16614756 PENTACON From review: PubMed:19095631;From review: PubMed:20059330 AAP 4/21/2014 3 3300005869 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity blood pressure was elevated by PGHS-2 deletion or mutation or by treatment with the PGHS-2 inhibitor celecoxib compared with that of WT controls on a regular chow diet negative regulation of blood pressure GO:0045776 Y Y ECO:0000006 PubMed:16614756 PENTACON From review: PubMed:19095631;From review: PubMed:20059330 AAP 4/21/2014 3 3300005870 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity Expression of COX-2, but not COX-1 mRNA, was increased in the older GhOEs compared with WTs. heart BTO:0000562 cardiac muscle cell CL:0000746 Y Y ECO:0000006 PubMed:12702643 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005871 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity Expression of COX-2, but not COX-1 mRNA, was increased in the older GhOEs compared with WTs. heart UBERON:0000948 cardiac muscle cell CL:0000746 Y Y ECO:0000006 PubMed:12702643 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005872 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Expression of COX-2, but not COX-1 mRNA, was increased in the older GhOEs compared with WTs. heart BTO:0000562 cardiac muscle cell CL:0000746 heart disease DOID:114 Y Y ECO:0000006 PubMed:12702643 PENTACON From review: PubMed:19095631; in Gh overexpressing cells AAP 4/21/2014 3 3300005873 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Expression of COX-2, but not COX-1 mRNA, was increased in the older GhOEs compared with WTs. heart UBERON:0000948 cardiac muscle cell CL:0000746 heart disease DOID:114 Y Y ECO:0000006 PubMed:12702643 PENTACON From review: PubMed:19095631; in Gh overexpressing cells AAP 4/21/2014 3 3300005874 Jenn/Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 protects retinal vessels from thrombosis, limiting the area of retinal nonperfusion in oxygen-induced retinopathy. response to wounding GO:0009611 vasculature of retina UBERON:0004864 Y Y ECO:0000006 PubMed:16688111 PENTACON From review: PubMed:19095631;From review: PubMed:20059330 AAP 4/21/2014 3 3300005875 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Immunocytochemical studies revealed that COX-2–expressing cells were localized exclusively in atherosclerotic lesions and not in unaffected areas of the artery. aortic atherosclerosis DOID:10230 Y Y ECO:0000006 PubMed:11956125 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005876 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 expression was detected in endothelial cells, smooth muscle cells, and monocyte/macrophages in murine atherosclerotic lesions endothelial cell CL:0000115 aortic atherosclerosis DOID:10230 Y Y ECO:0000006 PubMed:11956125 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005877 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 expression was detected in endothelial cells, smooth muscle cells, and monocyte/macrophages in murine atherosclerotic lesions aortic smooth muscle cell CL:0002539 aortic atherosclerosis DOID:10230 Y Y ECO:0000006 PubMed:11956125 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005878 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 expression was detected in endothelial cells, smooth muscle cells, and monocyte/macrophages in murine atherosclerotic lesions monocyte CL:0000576 aortic atherosclerosis DOID:10230 Y Y ECO:0000006 PubMed:11956125 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005879 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 expression could be clearly identified in endothelium-denuded abdominal aortas as well as medial smooth muscle layer but not in the adventitia abdominal aorta BTO:0002976 aortic smooth muscle cell CL:0002539 Y Y ECO:0000006 PubMed:16645140 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005880 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 expression could be clearly identified in endothelium-denuded abdominal aortas as well as medial smooth muscle layer but not in the adventitia abdominal aorta UBERON:0001516 aortic smooth muscle cell CL:0002539 Y Y ECO:0000006 PubMed:16645140 PENTACON From review: PubMed:19095631 AAP 4/21/2014 3 3300005881 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity there were a little COX-1 and COX-2 staining of the vascular walls of the thoracic aorta aorta thoracica BTO:0000157 Y Y ECO:0000006 PubMed:16440326 PENTACON From review: PubMed:17003913 AAP 4/21/2014 3 3300005882 Jenn P22437 19224 Ptgs1 Mus musculus 10090 Comment/tissue specificity there were a little COX-1 and COX-2 staining of the vascular walls of the thoracic aorta thoracic aorta UBERON:0001515 Y Y ECO:0000006 PubMed:16440326 PENTACON From review: PubMed:17003913 AAP 4/21/2014 3 3300005883 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity there were a little COX-1 and COX-2 staining of the vascular walls of the thoracic aorta Y Y ECO:0000006 PubMed:16440326 PENTACON From review: PubMed:17003913 AAP 4/21/2014 3 3300005884 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity In IP-/- mice the prostacyclin analogue, cicaprost, did not inhibit ADP-induced platelet aggregation negative regulation of platelet aggregation GO:0090331 blood platelet BTO:0000132 platelet CL:0000233 Y Y ECO:0000006 PubMed:9262402 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005885 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Aortic rings isolated from IP-/- mice did not relax in response to cicaprost, although the aorta from wild-type mice did positive regulation of vasodilation GO:0045909 aorta BTO:0000135 Y Y ECO:0000006 PubMed:9262402 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005886 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Aortic rings isolated from IP-/- mice did not relax in response to cicaprost, although the aorta from wild-type mice did positive regulation of vasodilation GO:0045909 aorta UBERON:0000947 Y Y ECO:0000006 PubMed:9262402 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005887 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Intravenous injection of cicaprost caused hypotension in anaesthetized wild-type mice, whereas there was no change in blood pressure in IP-/- mice negative regulation of blood pressure GO:0045776 Y Y ECO:0000006 PubMed:9262402 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005888 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity The bilateral carotid arteries of wild-type and IP-/-mice were exposed and topically painted with 7.5% FeCl3 solution, a procedure known to injure the endothelium. Most of the arteries of wild-type mice showed only mural thrombi of yellowish colour. In contrast, about two-thirds showed obstructive thrombi with reddish tails (in IP-/-mice). FeCl3 treatment for a longer period led to 30% of IP-deficient mice (4 out of 12) dying within 1 day owing to bilateral occlusions of the carotid arteries and/or embolic stroke, whereas the wild-type mice (n = 13) all survived this period. Inflammatory and pain responses in IP -/- mice are reduced to the levels observed in indomethacin-treated wild-type mice response to wounding GO:0009611 carotid artery BTO:0000168 Y Y ECO:0000006 PubMed:9262402 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005889 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity The bilateral carotid arteries of wild-type and IP-/-mice were exposed and topically painted with 7.5% FeCl3 solution, a procedure known to injure the endothelium. Most of the arteries of wild-type mice showed only mural thrombi of yellowish colour. In contrast, about two-thirds showed obstructive thrombi with reddish tails (in IP-/-mice). FeCl3 treatment for a longer period led to 30% of IP-deficient mice (4 out of 12) dying within 1 day owing to bilateral occlusions of the carotid arteries and/or embolic stroke, whereas the wild-type mice (n = 13) all survived this period. Inflammatory and pain responses in IP -/- mice are reduced to the levels observed in indomethacin-treated wild-type mice response to wounding GO:0009611 carotid UBERON:3010217 Y Y ECO:0000006 PubMed:9262402 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005890 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Injury-induced (in carotid artery) vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist. The augmented response to vascular injury was abolished in mice deficient in both receptors response to wounding GO:0009611 carotid artery BTO:0000168 Y Y ECO:0000006 PubMed:11964481 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005891 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Injury-induced (in carotid artery) vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist. The augmented response to vascular injury was abolished in mice deficient in both receptors response to wounding GO:0009611 carotid UBERON:3010217 Y Y ECO:0000006 PubMed:11964481 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005892 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Injury-induced (in carotid artery) vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist. The augmented response to vascular injury was abolished in mice deficient in both receptors negative regulation of cell proliferation GO:0008285 carotid artery BTO:0000168 Y Y ECO:0000006 PubMed:11964481 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005893 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Injury-induced (in carotid artery) vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist. The augmented response to vascular injury was abolished in mice deficient in both receptors negative regulation of cell proliferation GO:0008285 carotid UBERON:3010217 Y Y ECO:0000006 PubMed:11964481 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005894 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Injury-induced (in carotid artery) vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist. The augmented response to vascular injury was abolished in mice deficient in both receptors negative regulation of platelet activation GO:0010544 carotid artery BTO:0000168 Y Y ECO:0000006 PubMed:11964481 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005895 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Injury-induced (in carotid artery) vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist. The augmented response to vascular injury was abolished in mice deficient in both receptors negative regulation of platelet activation GO:0010544 carotid UBERON:3010217 Y Y ECO:0000006 PubMed:11964481 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005896 Faith P30987 21390 Tbxa2r Mus musculus 10090 Comment/tissue specificity Injury-induced (in carotid artery) vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist. The augmented response to vascular injury was abolished in mice deficient in both receptors response to wounding GO:0009611 carotid artery BTO:0000168 Y Y ECO:0000006 PubMed:11964481 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005897 Faith P30987 21390 Tbxa2r Mus musculus 10090 Comment/tissue specificity Injury-induced (in carotid artery) vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist. The augmented response to vascular injury was abolished in mice deficient in both receptors response to wounding GO:0009611 carotid UBERON:3010217 Y Y ECO:0000006 PubMed:11964481 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005898 Faith P30987 21390 Tbxa2r Mus musculus 10090 Comment/tissue specificity Injury-induced (in carotid artery) vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist. The augmented response to vascular injury was abolished in mice deficient in both receptors positive regulation of cell proliferation GO:0008284 carotid artery BTO:0000168 Y Y ECO:0000006 PubMed:11964481 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005899 Faith P30987 21390 Tbxa2r Mus musculus 10090 Comment/tissue specificity Injury-induced (in carotid artery) vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist. The augmented response to vascular injury was abolished in mice deficient in both receptors positive regulation of cell proliferation GO:0008284 carotid UBERON:3010217 Y Y ECO:0000006 PubMed:11964481 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005900 Faith P30987 21390 Tbxa2r Mus musculus 10090 Comment/tissue specificity Injury-induced (in carotid artery) vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist. The augmented response to vascular injury was abolished in mice deficient in both receptors positive regulation of platelet activation GO:0010572 carotid artery BTO:0000168 Y Y ECO:0000006 PubMed:11964481 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005901 Faith P30987 21390 Tbxa2r Mus musculus 10090 Comment/tissue specificity Injury-induced (in carotid artery) vascular proliferation and platelet activation are enhanced in mice that are genetically deficient in the PGI2 receptor (IP) but are depressed in mice genetically deficient in the TxA2 receptor (TP) or treated with a TP antagonist. The augmented response to vascular injury was abolished in mice deficient in both receptors positive regulation of platelet activation GO:0010572 carotid UBERON:3010217 Y Y ECO:0000006 PubMed:11964481 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005902 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Deleting one copy of IP reduced the blood pressure response and reduced the suppressive effect to platelet aggregation after administering IP agonist cicaprost. Time to complete occlusion after photochemical injury was reduced in IP+/- and IP-/- mice. negative regulation of blood pressure GO:0045776 Y Y ECO:0000006 PubMed:16614756 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005903 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Deleting one copy of IP reduced the blood pressure response and reduced the suppressive effect to platelet aggregation after administering IP agonist cicaprost. Time to complete occlusion after photochemical injury was reduced in IP+/- and IP-/- mice. negative regulation of platelet aggregation GO:0090331 blood platelet BTO:0000132 platelet CL:0000233 Y Y ECO:0000006 PubMed:16614756 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005904 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Deleting one copy of IP reduced the blood pressure response and reduced the suppressive effect to platelet aggregation after administering IP agonist cicaprost. Time to complete occlusion after photochemical injury was reduced in IP+/- and IP-/- mice. response to wounding GO:0009611 vasculature BTO:0003718 Y Y ECO:0000006 PubMed:16614756 PENTACON From review: PubMed:20059330;GO term selected for thrombotic response AAP 4/21/2014 3 3300005905 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Deleting one copy of IP reduced the blood pressure response and reduced the suppressive effect to platelet aggregation after administering IP agonist cicaprost. Time to complete occlusion after photochemical injury was reduced in IP+/- and IP-/- mice. response to wounding GO:0009611 vasculature UBERON:0002049 Y Y ECO:0000006 PubMed:16614756 PENTACON From review: PubMed:20059330;GO term selected for thrombotic response AAP 4/21/2014 3 3300005906 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 gene deletion exacerbates pulmonary hypertension, enhances sensitivity to TXA(2), and induces intravascular thrombosis in response to hypoxia. response to hypoxia GO:0001666 vasculature BTO:0003718 Y Y ECO:0000006 PubMed:18375790 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005907 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 gene deletion exacerbates pulmonary hypertension, enhances sensitivity to TXA(2), and induces intravascular thrombosis in response to hypoxia. response to hypoxia GO:0001666 vasculature UBERON:0002049 Y Y ECO:0000006 PubMed:18375790 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005908 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 knockdown mice displayed an increased propensity for thrombogenesis comparted with wild-type littermates and produced 50% less prostacyclin negative regulation of blood coagulation GO:0030195 vasculature BTO:0003718 Y Y ECO:0000006 PubMed:19357295 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005909 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity COX-2 knockdown mice displayed an increased propensity for thrombogenesis comparted with wild-type littermates and produced 50% less prostacyclin negative regulation of blood coagulation GO:0030195 vasculature UBERON:0002049 Y Y ECO:0000006 PubMed:19357295 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005910 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity The thrombotic response was accelerated in mice in which COX-2 was specifically deleted in endothelial cells using a cre/Lox system and in mice in which COX-2 was specifically deleted in vascular smooth muscle cells. negative regulation of blood coagulation GO:0030195 vascular endothelial cell BTO:0001854 blood vessel endothelial cell CL:0000071 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005911 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity The thrombotic response was accelerated in mice in which COX-2 was specifically deleted in endothelial cells using a cre/Lox system and in mice in which COX-2 was specifically deleted in vascular smooth muscle cells. negative regulation of blood coagulation GO:0030195 vasculature UBERON:0002049 blood vessel endothelial cell CL:0000071 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005912 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity The thrombotic response was accelerated in mice in which COX-2 was specifically deleted in endothelial cells using a cre/Lox system and in mice in which COX-2 was specifically deleted in vascular smooth muscle cells. negative regulation of blood coagulation GO:0030195 vascular smooth muscle cell BTO:0004578 vascular associated smooth muscle cell CL:0000359 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005913 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity The thrombotic response was accelerated in mice in which COX-2 was specifically deleted in endothelial cells using a cre/Lox system and in mice in which COX-2 was specifically deleted in vascular smooth muscle cells. negative regulation of blood coagulation GO:0030195 vasculature UBERON:0002049 vascular associated smooth muscle cell CL:0000359 Y Y ECO:0000033 PubMed:20059330 PENTACON AAP 4/21/2014 3 3300005914 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Deletion of the PGI2 receptor (IP) or suppression of PGI2 with the selective COX-2 inhibitor, nimesulide, both augment intimal hyperplasia while preserving luminal geometry in mouse models of transplant arteriosclerosis or flow-induced vascular remodeling. Moreover, nimesulide or IP deletion augments the reduction in blood flow caused by common carotid artery ligation in wild-type mice. negative regulation of blood vessel remodeling GO:0060313 vasculature BTO:0003718 Y Y ECO:0000006 PubMed:15905461 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005915 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Deletion of the PGI2 receptor (IP) or suppression of PGI2 with the selective COX-2 inhibitor, nimesulide, both augment intimal hyperplasia while preserving luminal geometry in mouse models of transplant arteriosclerosis or flow-induced vascular remodeling. Moreover, nimesulide or IP deletion augments the reduction in blood flow caused by common carotid artery ligation in wild-type mice. negative regulation of blood vessel remodeling GO:0060313 vasculature UBERON:0002049 Y Y ECO:0000006 PubMed:15905461 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005916 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Deletion of the PGI2 receptor (IP) or suppression of PGI2 with the selective COX-2 inhibitor, nimesulide, both augment intimal hyperplasia while preserving luminal geometry in mouse models of transplant arteriosclerosis or flow-induced vascular remodeling. Moreover, nimesulide or IP deletion augments the reduction in blood flow caused by common carotid artery ligation in wild-type mice. negative regulation of blood vessel remodeling GO:0060313 vasculature BTO:0003718 Y Y ECO:0000006 PubMed:15905461 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005917 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Deletion of the PGI2 receptor (IP) or suppression of PGI2 with the selective COX-2 inhibitor, nimesulide, both augment intimal hyperplasia while preserving luminal geometry in mouse models of transplant arteriosclerosis or flow-induced vascular remodeling. Moreover, nimesulide or IP deletion augments the reduction in blood flow caused by common carotid artery ligation in wild-type mice. negative regulation of blood vessel remodeling GO:0060313 vasculature UBERON:0002049 Y Y ECO:0000006 PubMed:15905461 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005918 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Deletion of the PGI2 receptor (IP) or suppression of PGI2 with the selective COX-2 inhibitor, nimesulide, both augment intimal hyperplasia while preserving luminal geometry in mouse models of transplant arteriosclerosis or flow-induced vascular remodeling. Moreover, nimesulide or IP deletion augments the reduction in blood flow caused by common carotid artery ligation in wild-type mice. blood circulation GO:0008015 vasculature BTO:0003718 Y Y ECO:0000006 PubMed:15905461 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005919 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity Deletion of the PGI2 receptor (IP) or suppression of PGI2 with the selective COX-2 inhibitor, nimesulide, both augment intimal hyperplasia while preserving luminal geometry in mouse models of transplant arteriosclerosis or flow-induced vascular remodeling. Moreover, nimesulide or IP deletion augments the reduction in blood flow caused by common carotid artery ligation in wild-type mice. blood circulation GO:0008015 vasculature UBERON:0002049 Y Y ECO:0000006 PubMed:15905461 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005920 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Deletion of the PGI2 receptor (IP) or suppression of PGI2 with the selective COX-2 inhibitor, nimesulide, both augment intimal hyperplasia while preserving luminal geometry in mouse models of transplant arteriosclerosis or flow-induced vascular remodeling. Moreover, nimesulide or IP deletion augments the reduction in blood flow caused by common carotid artery ligation in wild-type mice. blood circulation GO:0008015 vasculature BTO:0003718 Y Y ECO:0000006 PubMed:15905461 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005921 Faith Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Deletion of the PGI2 receptor (IP) or suppression of PGI2 with the selective COX-2 inhibitor, nimesulide, both augment intimal hyperplasia while preserving luminal geometry in mouse models of transplant arteriosclerosis or flow-induced vascular remodeling. Moreover, nimesulide or IP deletion augments the reduction in blood flow caused by common carotid artery ligation in wild-type mice. blood circulation GO:0008015 vasculature UBERON:0002049 Y Y ECO:0000006 PubMed:15905461 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005922 Faith P30987 21390 Tbxa2r Mus musculus 10090 Comment/involvement in disease apoE-/-TP-/- mice exhibited a significant delay in atherogenesis compared with mice deficient in apoE alone. P-selectin expression was only marginally induced at 0.3 U/ml thrombin in the platelets of apoE–/–TP–/– mice vasculature BTO:0003718 atherosclerosis DOID:1936 Atherosclerosis of artery SNOMEDCT:441574008 Y Y ECO:0000006 PubMed:15372102 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005923 Faith P30987 21390 Tbxa2r Mus musculus 10090 Comment/involvement in disease apoE-/-TP-/- mice exhibited a significant delay in atherogenesis compared with mice deficient in apoE alone. P-selectin expression was only marginally induced at 0.3 U/ml thrombin in the platelets of apoE–/–TP–/– mice vasculature UBERON:0002049 atherosclerosis DOID:1936 Atherosclerosis of artery SNOMEDCT:441574008 Y Y ECO:0000006 PubMed:15372102 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005924 Faith P30987 21390 Tbxa2r Mus musculus 10090 Comment/tissue specificity apoE-/-TP-/- mice exhibited a significant delay in atherogenesis compared with mice deficient in apoE alone. P-selectin expression was only marginally induced at 0.3 U/ml thrombin in the platelets of apoE–/–TP–/– mice blood platelet BTO:0000132 platelet CL:0000233 atherosclerosis DOID:1936 Y Y ECO:0000006 PubMed:15372102 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005925 Faith P30987 21390 Tbxa2r Mus musculus 10090 Comment/tissue specificity apoE-/-TP-/- mice exhibited a significant delay in atherogenesis compared with mice deficient in apoE alone. P-selectin expression was only marginally induced at 0.3 U/ml thrombin in the platelets of apoE–/–TP–/– mice vasculature UBERON:0002049 platelet CL:0000233 atherosclerosis DOID:1936 Y Y ECO:0000006 PubMed:15372102 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005926 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity An increase in the P-selectin expression was detected at doses as low as 0.1 U/ml and increased significantly with 0.2 U/ml thrombin in the platelets of apoE–/–IP–/– mice. Intravital microscopy of the common carotid artery revealed a significantly greater number of leukocytes rolling on the vessel walls in apoE-/-IP-/- mice than in either apoE-/-TP-/- or apoE-/- mice. negative regulation of platelet activation GO:0010544 blood platelet BTO:0000132 platelet CL:0000233 Y Y ECO:0000006 PubMed:15372102 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005927 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity An increase in the P-selectin expression was detected at doses as low as 0.1 U/ml and increased significantly with 0.2 U/ml thrombin in the platelets of apoE–/–IP–/– mice. Intravital microscopy of the common carotid artery revealed a significantly greater number of leukocytes rolling on the vessel walls in apoE-/-IP-/- mice than in either apoE-/-TP-/- or apoE-/- mice. negative regulation of platelet activation GO:0010544 vasculature UBERON:0002049 platelet CL:0000233 Y Y ECO:0000006 PubMed:15372102 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005928 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity An increase in the P-selectin expression was detected at doses as low as 0.1 U/ml and increased significantly with 0.2 U/ml thrombin in the platelets of apoE–/–IP–/– mice. Intravital microscopy of the common carotid artery revealed a significantly greater number of leukocytes rolling on the vessel walls in apoE-/-IP-/- mice than in either apoE-/-TP-/- or apoE-/- mice. ICAM-1 expression in apoE–/–IP–/– mice significantly increased in endothelial cells overlying the lesions negative regulation of cell-cell adhesion GO:0022408 vasculature BTO:0003718 Y Y ECO:0000006 PubMed:15372102 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005929 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity An increase in the P-selectin expression was detected at doses as low as 0.1 U/ml and increased significantly with 0.2 U/ml thrombin in the platelets of apoE–/–IP–/– mice. Intravital microscopy of the common carotid artery revealed a significantly greater number of leukocytes rolling on the vessel walls in apoE-/-IP-/- mice than in either apoE-/-TP-/- or apoE-/- mice. ICAM-1 expression in apoE–/–IP–/– mice significantly increased in endothelial cells overlying the lesions negative regulation of cell-cell adhesion GO:0022408 vasculature UBERON:0002049 Y Y ECO:0000006 PubMed:15372102 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005930 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity An increase in the P-selectin expression was detected at doses as low as 0.1 U/ml and increased significantly with 0.2 U/ml thrombin in the platelets of apoE–/–IP–/– mice. Intravital microscopy of the common carotid artery revealed a significantly greater number of leukocytes rolling on the vessel walls in apoE-/-IP-/- mice than in either apoE-/-TP-/- or apoE-/- mice. ICAM-1 expression in apoE–/–IP–/– mice significantly increased in endothelial cells overlying the lesions endothelial cell activation GO:0042118 vascular endothelial cell BTO:0001854 blood vessel endothelial cell CL:0000071 Y Y ECO:0000006 PubMed:15372102 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005931 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity An increase in the P-selectin expression was detected at doses as low as 0.1 U/ml and increased significantly with 0.2 U/ml thrombin in the platelets of apoE–/–IP–/– mice. Intravital microscopy of the common carotid artery revealed a significantly greater number of leukocytes rolling on the vessel walls in apoE-/-IP-/- mice than in either apoE-/-TP-/- or apoE-/- mice. ICAM-1 expression in apoE–/–IP–/– mice significantly increased in endothelial cells overlying the lesions endothelial cell activation GO:0042118 blood vessel endothelium UBERON:0004638 blood vessel endothelial cell CL:0000071 Y Y ECO:0000006 PubMed:15372102 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005932 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity IP deletion in female mice on an atherosclerotic background led to an increase in a measure of oxidative stress, increased excretion of the urinary isoprostane 8,12-iso-iPF2alpha-VI. Aortic smooth muscle cells exposed to hydrogen peroxide increased lipid peroxidation in mice with IP deleted. negative regulation of response to reactive oxygen species GO:1901032 aortic smooth muscle cell BTO:0004577 aortic smooth muscle cell CL:0002539 Y Y ECO:0000006 PubMed:15372102 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005933 Faith P43119 19222 Ptgir Mus musculus 10090 Comment/tissue specificity IP deletion in female mice on an atherosclerotic background led to an increase in a measure of oxidative stress, increased excretion of the urinary isoprostane 8,12-iso-iPF2alpha-VI. Aortic smooth muscle cells exposed to hydrogen peroxide increased lipid peroxidation in mice with IP deleted. negative regulation of response to reactive oxygen species GO:1901032 aorta smooth muscle tissue UBERON:0004178 aortic smooth muscle cell CL:0002539 Y Y ECO:0000006 PubMed:15372102 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005934 Faith Q9JM51 64292 Ptges Mus musculus 10090 Comment/involvement in disease mPGES-1-derived PGE(2) accelerates atherogenesis in LDLR(-/-) mice atherosclerosis DOID:1936 Y Y ECO:0000006 PubMed:16973753 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005935 Faith Q9JM51 64292 Ptges Mus musculus 10090 Comment/involvement in disease mPGES-1-derived PGE(2) accelerates atherogenesis in LDLR(-/-) mice Atherosclerosis of artery SNOMEDCT:441574008 Y Y ECO:0000006 PubMed:16973753 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005936 Faith Q9JM51 64292 Ptges Mus musculus 10090 Comment/involvement in disease mPGES-1 deletion attenuates ang II–induced aortic aneurysm aortic aneurysm DOID:3627 Y Y ECO:0000006 PubMed:18285567 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005937 Faith Q9JM51 64292 Ptges Mus musculus 10090 Comment/involvement in disease mPGES-1 deletion attenuates ang II–induced aortic aneurysm Aortic aneurysm SNOMEDCT:155419006 Y Y ECO:0000006 PubMed:18285567 PENTACON From review: PubMed:20059330 AAP 4/21/2014 3 3300005938 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity We recently found that selective deletion of cardiomyocyte COX-2 resulted in heart failure and cardiac fibrosis in mice (unpublished observations), In an alternative heart failure model, COX-2-derived TXA2 contributed to oxidant stress and isoprostane generation to increase cardiomyocyte apoptosis and fibrosis parenchyma BTO:0001539 cardiac muscle cell CL:0000746 heart disease DOID:114 Y Y ECO:0000033 PubMed:19095631 PENTACON AAP 4/21/2014 3 3300005939 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cox2-/- mice show renal failure of developmental origin with few functioning nephrons and an abundance of undeveloped mesechymal tissue, medullary hypoplasia, increased blood urea nitrogen and serum creatinine and other kidney abnormalities nephron development GO:0072006 kidney BTO:0000671 embryo BTO:0000379 Y Y ECO:0000006 PubMed:7477380 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300009544 Jenn Q05769 19225 Ptgs2 Mus musculus 10090 Comment/tissue specificity Cox2-/- mice show renal failure of developmental origin with few functioning nephrons and an abundance of undeveloped mesechymal tissue, medullary hypoplasia, increased blood urea nitrogen and serum creatinine and other kidney abnormalities nephron development GO:0072006 metanephric mesenchyme UBERON:0003220 embryo BTO:0000379 Y Y ECO:0000006 PubMed:7477380 PENTACON From review: PubMed:17361113; From review: PubMed:19095631 AAP 4/21/2014 3 3300009545