Curator Name UniProt ID NCBI Gene ID Gene Name Species Name Taxonomy ID Data Type Data Value KM or Vmax Unit ChEBI Chemical Term A ChEBI Chemical ID A ChEBI Chemical Term B ChEBI Chemical ID B Secondary Source IDs Secondary Source Notes Reviewed (Y/N) Use (Y/N) Evidence Code Primary Source Secondary Source PENTACON Notes Gene Set Secondary Source Version Date Secondary Source Version PENTACON Annotation No Rose P24752 38 ACAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4 uM for acteoacetyl coenzyme A 4 uM acetoacetyl-CoA CHEBI:15345 Y Y ECO:0000006 PubMed:17371050 UniProtKB AAP 11/28/2012 141 2000000001 Rose P24752 38 ACAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 20 uM for coenzyme A 20 uM acetoacetyl-CoA CHEBI:15345 Y Y ECO:0000311 UniProtKB AAP 11/28/2012 141 2000000002 Rose P24752 38 ACAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 8 uM for 2-methylacteoacetyl coenzyme A 8 uM acetoacetyl-CoA CHEBI:15345 Y Y ECO:0000311 UniProtKB 2-methylacteoacetyl coenzyme A not in ChEBI, send request. AAP 11/28/2012 141 2000000003 Rose P24752 38 ACAT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 508 uM for acetyl coenzyme A 508 uM acetoacetyl-CoA CHEBI:15345 Y Y ECO:0000311 UniProtKB AAP 11/28/2012 141 2000000004 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 35.8 uM for C10-acyl-CoA 35.8 uM decanoyl-CoA CHEBI:28493 Y Y ECO:0000006 PubMed:16940157 UniProtKB AAP 5/1/2013 87 2000000005 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 3.6 uM for C12-acyl-CoA 3.6 uM lauroyl-CoA CHEBI:15521 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2000000006 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.8 uM for C14-acyl-CoA 2.8 uM myristoyl-CoA CHEBI:15532 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2000000007 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 3.6 uM for C16-acyl-CoA 3.6 uM palmitoyl-CoA CHEBI:15525 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2000000008 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.4 uM for C18-acyl-CoA 2.4 uM stearoyl-CoA CHEBI:15541 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2000000009 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2 uM for C20-acyl-CoA 2 uM icosanoyl-CoA CHEBI:15527 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2000000010 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.4 uM for C16:1-acyl-CoA 2.4 uM hexadecenoyl-CoA CHEBI:24549 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2000000011 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4.1 uM for C18:1-acyl-CoA 4.1 uM unsaturated fatty acyl-CoA CHEBI:51006 Y Y PubMed:16940157 UniProtKB C18:1-acyl-CoA (should we assume that this is oleoyl-CoA?) AAP 5/1/2013 87 2000000012 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.1 uM for C18:1-trans-acyl-CoA 2.1 uM unsaturated fatty acyl-CoA CHEBI:51006 Y Y PubMed:16940157 UniProtKB C18:1-trans-acyl-CoA AAP 5/1/2013 87 2000000013 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 224 nmol/min/mg enzyme toward C10-acyl-CoA 224 nmol/min/mg decanoyl-CoA CHEBI:28493 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2000000014 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 700 nmol/min/mg enzyme toward C12-acyl-CoA 700 nmol/min/mg lauroyl-CoA CHEBI:15521 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2000000015 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 912 nmol/min/mg enzyme toward C14-acyl-CoA 912 nmol/min/mg myristoyl-CoA CHEBI:15532 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2000000016 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 691 nmol/min/mg enzyme toward C16-acyl-CoA 691 nmol/min/mg palmitoyl-CoA CHEBI:15525 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2000000017 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 597 nmol/min/mg enzyme toward C18-acyl-CoA 597 nmol/min/mg stearoyl-CoA CHEBI:15541 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2000000018 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 520 nmol/min/mg enzyme toward C20-acyl-CoA 520 nmol/min/mg icosanoyl-CoA CHEBI:15527 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2000000019 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 577 nmol/min/mg enzyme toward C16:1-acyl-CoA 577 nmol/min/mg hexadecenoyl-CoA CHEBI:24549 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 87 2000000020 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 258 nmol/min/mg enzyme toward C18:1-acyl-CoA 258 nmol/min/mg unsaturated fatty acyl-CoA CHEBI:51006 Y Y PubMed:16940157 UniProtKB C18:1-acyl-CoA (should we assume that this is oleoyl-CoA?) AAP 5/1/2013 87 2000000021 Faith Q86TX2 641371 ACOT1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 309 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA 309 nmol/min/mg unsaturated fatty acyl-CoA CHEBI:51006 Y Y PubMed:16940157 UniProtKB C18:1-trans-acyl-CoA AAP 5/1/2013 87 2000000022 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4.9 uM for n-decanoyl-CoA 4.9 uM decanoyl-CoA CHEBI:28493 Y Y ECO:0000006 PubMed:19170545 UniProtKB n-decanoyl-CoA AAP 5/29/2013 101 2000000023 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 26 uM for n-octanoyl-CoA 26 uM octanoyl-CoA CHEBI:15533 Y Y PubMed:19170545 UniProtKB n-octanoyl-CoA AAP 5/29/2013 101 2000000024 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 5 uM for myristoyl-CoA 5 uM myristoyl-CoA CHEBI:15532 Y Y UniProtKB AAP 5/29/2013 101 2000000025 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 9 uM for palmitoyl-CoA 9 uM palmitoyl-CoA CHEBI:15525 Y Y UniProtKB AAP 5/29/2013 101 2000000026 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 9 uM for oleoyl-CoA 9 uM oleoyl-CoA CHEBI:15534 Y Y UniProtKB AAP 5/29/2013 101 2000000027 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 10 uM for 3,4-dihydrohyphenylacetyl-CoA 10 uM phenylacetyl-CoAs CHEBI:25981 Y Y PubMed:19170545 UniProtKB Typo in UniProt will be fixed in October release. Chemical name is 3,4-dihydroxyphenylacetyl-CoA (not in ChEBI). AAP 5/29/2013 101 2000000028 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 40 uM for 3-hydrohyphenylacetyl-CoA 40 uM phenylacetyl-CoAs CHEBI:25981 Y Y PubMed:19170545 UniProtKB Typo in UniProt will be fixed in October release. Chemical name is 3-hydroxyphenylacetyl-CoA (not in ChEBI). AAP 5/29/2013 101 2000000029 Faith Q9NPJ3 55856 ACOT13 Homo sapiens 9606 Comment/biophysicochemical properties/KM 20 uM for arachidonoyl-CoA 20 uM arachidonoyl-CoA CHEBI:15514 Y Y PubMed:19170545 Many substrates from this paper are not listed in UniProt. I added this one due to the scope of PENTACON. AAP 5/29/2013 101 2000000030 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 40.3 uM for C10-acyl-CoA 40.3 uM decanoyl-CoA CHEBI:28493 Y Y ECO:0000006 PubMed:16940157 UniProtKB AAP 5/29/2013 127 2000000031 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 8.9 uM for C12-acyl-CoA 8.9 uM lauroyl-CoA CHEBI:15521 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2000000032 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 1.6 uM for C14-acyl-CoA 1.6 uM myristoyl-CoA CHEBI:15532 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2000000033 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.0 uM for C16-acyl-CoA 2 uM palmitoyl-CoA CHEBI:15525 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2000000034 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.8 uM for C18-acyl-CoA 2.8 uM stearoyl-CoA CHEBI:15541 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2000000035 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4.8 uM for C20-acyl-CoA 4.8 uM icosanoyl-CoA CHEBI:15527 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2000000036 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4.5 uM for C16:1-acyl-CoA 4.5 uM hexadecenoyl-CoA CHEBI:24549 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2000000037 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 6.1 uM for C18:1-acyl-CoA 6.1 uM unsaturated fatty acyl-CoA CHEBI:51006 Y Y UniProtKB C18:1-acyl-CoA (should we assume that this is oleoyl-CoA?) AAP 5/29/2013 127 2000000038 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4.3 uM for C18:1-trans-acyl-CoA 4.3 uM unsaturated fatty acyl-CoA CHEBI:51006 Y Y UniProtKB C18:1-trans-acyl-CoA AAP 5/29/2013 127 2000000039 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 212 nmol/min/mg enzyme toward C10-acyl-CoA 212 nmol/min/mg decanoyl-CoA CHEBI:28493 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2000000040 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 681 nmol/min/mg enzyme toward C12-acyl-CoA 681 nmol/min/mg lauroyl-CoA CHEBI:15521 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2000000041 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 766 nmol/min/mg enzyme toward C14-acyl-CoA 766 nmol/min/mg myristoyl-CoA CHEBI:15532 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2000000042 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 656 nmol/min/mg enzyme toward C16-acyl-CoA 656 nmol/min/mg palmitoyl-CoA CHEBI:15525 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2000000043 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 488 nmol/min/mg enzyme toward C18-acyl-CoA 488 nmol/min/mg stearoyl-CoA CHEBI:15541 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2000000044 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 408 nmol/min/mg enzyme toward C20-acyl-CoA 408 nmol/min/mg icosanoyl-CoA CHEBI:15527 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2000000045 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 661 nmol/min/mg enzyme toward C16:1-acyl-CoA 661 nmol/min/mg hexadecenoyl-CoA CHEBI:24549 Y Y PubMed:16940157 UniProtKB AAP 5/29/2013 127 2000000046 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 304 nmol/min/mg enzyme toward C18:1-acyl-CoA 304 nmol/min/mg unsaturated fatty acyl-CoA CHEBI:51006 Y Y UniProtKB C18:1-acyl-CoA (should we assume that this is oleoyl-CoA?) AAP 5/29/2013 127 2000000047 Faith P49753 10965 ACOT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 418 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA 418 nmol/min/mg unsaturated fatty acyl-CoA CHEBI:51006 Y Y UniProtKB C18:1-trans-acyl-CoA AAP 5/29/2013 127 2000000048 Faith Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/KM 14 uM for succinyl-CoA 14 uM succinyl-CoA CHEBI:15380 Y Y ECO:0000006 PubMed:16940157 UniProtKB AAP 5/1/2013 92 2000000049 Faith Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/KM 147 uM for glutaryl-CoA 147 uM glutaryl-CoA CHEBI:15524 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 92 2000000050 Faith Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/KM 3.4 uM for C14-acyl-CoA 3.4 uM myristoyl-CoA CHEBI:15532 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 92 2000000051 Faith Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 581 nmol/min/mg enzyme toward succinyl-CoA 581 nmol/min/mg succinyl-CoA CHEBI:15380 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 92 2000000052 Faith Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 132 nmol/min/mg enzyme toward glutaryl-CoA 132 nmol/min/mg glutaryl-CoA CHEBI:15524 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 92 2000000053 Faith Q8N9L9 122970 ACOT4 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 137 nmol/min/mg enzyme toward C14-acyl-CoA 137 nmol/min/mg myristoyl-CoA CHEBI:15532 Y Y PubMed:16940157 UniProtKB AAP 5/1/2013 92 2000000054 Katie Q9ULC5 51703 ACSL5 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.11 uM for palmitic acid (isoform 1 at pH 7.5) 0.11 uM palmitic acid CHEBI:15756 Y Y ECO:0000006 PubMed:17681178 UniProtKB Curated by Faith. pH 7.5 AAP 11/28/2012 121 2000000055 Katie Q9ULC5 51703 ACSL5 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.38 uM for palmitic acid (isoform 1 at pH 9.5) 0.38 uM palmitic acid CHEBI:15756 Y Y ECO:0000311 UniProtKB Curated by Faith AAP 11/28/2012 121 2000000056 Katie Q9ULC5 51703 ACSL5 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.04 uM for palmitic acid (isoform 3 at pH 7.5) 0.04 uM palmitic acid CHEBI:15756 Y Y ECO:0000311 UniProtKB Curated by Faith AAP 11/28/2012 121 2000000057 Katie Q9ULC5 51703 ACSL5 Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.15 uM for palmitic acid (isoform 3 at pH 8.5) 0.15 uM palmitic acid CHEBI:15756 Y Y ECO:0000311 UniProtKB Curated by Faith AAP 11/28/2012 121 2000000058 Rose P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 1.0 uM for androstanediol 1 uM androstane-3,17-diol CHEBI:27727 Y Y ECO:0000311 UniProtKB AAP 2/6/2013 142 2000000059 Rose P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 4.4 nmol/min/mg enzyme with androstanediol as substrate 4.4 nmol/min/mg androstane-3,17-diol CHEBI:27727 Y Y ECO:0000311 UniProtKB AAP 2/6/2013 142 2000000060 Rose P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 142.1 uM for progesterone 142.1 uM progesterone CHEBI:17026 Y Y ECO:0000006 PubMed:10557352 UniProtKB AAP 2/6/2013 142 2000000061 Rose P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 20.1 nmol/min/mg enzyme with progesterone as substrate 20.1 nmol/min/mg progesterone CHEBI:17026 Y Y ECO:0000311 UniProtKB AAP 2/6/2013 142 2000000062 Rose P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.37 uM for 5-alpha-dihydrotestosterone 2.37 uM testosterone CHEBI:17347 Y Y ECO:0000311 UniProtKB 5-alpha-dihydrotestosterone not in ChEBI, send request. AAP 2/6/2013 142 2000000063 Rose P42330 8644 AKR1C3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1.8 nmol/min/mg enzyme with 5-alpha-dihydrotestosterone as substrate 1.8 nmol/min/mg testosterone CHEBI:17347 Y Y ECO:0000311 UniProtKB AAP 2/6/2013 142 2000000064 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 524 pmol/min/mg hexadecan-1-ol CHEBI:16125 palmitoyl-CoA CHEBI:15525 Y Y ECO:0000006 PubMed:15671038 Two substrates, where first substrate is [14C] labeled. Info added from publication AAP 10/31/2012 72 2000000065 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 11.4 pmol/min/mg 1,2-dioleoyl-sn-glycerol CHEBI:52333 oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 Two substrates, where second substrate is [14C] labeled. Info added from publication AAP 10/31/2012 72 2000000066 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 27 pmol/min/mg Arachidyl C-20 alcohol oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 I cannot find the first substrate. The class is 'fatty alcohol'. There is also a 'arachidyl group' in ChEBI. Two substrates, where second substrate is [14C] labeled. Info added from publication Request: arachidyl alcohol AAP 10/31/2012 72 2000000067 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax -50 pmol/min/mg decan-1-ol CHEBI:28903 oleoyl-CoA CHEBI:15534 Y N ECO:0000006 PubMed:15671038 No activity; the negative number may reflect the removal of background. Two substrates, where second substrate is [14C] labeled. Info added from publication AAP 10/31/2012 72 2000000068 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1232 pmol/min/mg enzyme with [14C]cetyl-CoA as substrate 1232 pmol/min/mg hexadecan-1-ol CHEBI:16125 oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 UniProtKB Info in UniProt is incorrect. I will send an email to UniProt. Substrate 1 is [14C] labeled hexadecan-1-ol AAP 10/31/2012 72 2000000069 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1066 pmol/min/mg hexadecan-1-ol CHEBI:16125 oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 Two substrates, where second substrate is [14C] labeled. Info added from publication AAP 10/31/2012 72 2000000070 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 665 pmol/min/mg hexadecan-1-ol CHEBI:16125 oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 Two substrates, where second substrate is [14C] labeled. Info added from publication AAP 10/31/2012 72 2000000071 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 892 pmol/min/mg Oleyl C-18:1 alcohol oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 Two substrates, where second substrate is [14C] labeled. Info added from publication Request: oleyl alcohol AAP 10/31/2012 72 2000000072 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 582 pmol/min/mg Palmitoleyl C-16:1 alcohol oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 Two substrates, where second substrate is [14C] labeled. Info added from publication Request: palmitoleyl alcohol AAP 10/31/2012 72 2000000073 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 138 pmol/min/mg stearyl alcohol CHEBI:32154 oleoyl-CoA CHEBI:15534 Y Y ECO:0000006 PubMed:15671038 Two substrates, where second substrate is [14C] labeled. Info added from publication AAP 10/31/2012 72 2000000074 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 549 pmol/min/mg hexadecan-1-ol CHEBI:16125 stearoyl-CoA CHEBI:15541 Y Y ECO:0000006 PubMed:15671038 Two substrates, where first substrate is [14C] labeled. Info added from publication AAP 10/31/2012 72 2000000075 Faith Q6E213 158835 AWAT2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1125 pmol/min/mg hexadecan-1-ol CHEBI:16125 palmitoleoyl-CoA CHEBI:53152 Y Y ECO:0000006 PubMed:15671038 Two substrates, where first substrate is [14C] labeled. Info added from publication AAP 10/31/2012 72 2000000076 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/KM 1.1 mM for taurine toward choloyl-CoA 1.1 mM taurine CHEBI:15891 choloyl-CoA CHEBI:15519 Y Y ECO:0000006 PubMed:8034703 UniProtKB AAP 5/1/2013 102 2000000077 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.2 mM for 2-fluoro-beta-alanine toward choloyl-CoA 2.2 mM beta-alanine derivative CHEBI:22823 Y Y UniProtKB 2-fluoro-beta-alanine AAP 5/1/2013 102 2000000078 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/KM 5.8 mM for glycine toward choloyl-CoA 5.8 mM glycine CHEBI:15428 choloyl-CoA CHEBI:15519 Y Y UniProtKB AAP 5/1/2013 102 2000000079 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/KM 19.3 uM for arachidoyl-CoA 19.3 uM icosanoyl-CoA CHEBI:15527 Y Y UniProtKB AAP 5/1/2013 102 2000000080 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.33 umol/min/mg enzyme with taurine as substrate for acyltransferase activity 0.33 umol/min/mg taurine CHEBI:15891 Y Y UniProtKB AAP 5/1/2013 102 2000000081 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.19 umol/min/mg enzyme with 2-fluoro-beta-alanine as substrate for acyltransferase activity 0.19 umol/min/mg beta-alanine derivative CHEBI:22823 Y Y UniProtKB 2-fluoro-beta-alanine AAP 5/1/2013 102 2000000082 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.77 umol/min/mg enzyme with glycine as substrate for acyltransferase activity 0.77 umol/min/mg glycine CHEBI:15428 Y Y UniProtKB AAP 5/1/2013 102 2000000083 Faith Q14032 570 BAAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 223 nmol/min/mg enzyme with arachidoyl-CoA as substrate for acyl-CoA thioesterase activity 223 nmol/min/mg icosanoyl-CoA CHEBI:15527 Y Y UniProtKB AAP 5/1/2013 102 2000000084 Mike P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 173 uM for daunorubicin 173 uM daunorubicin CHEBI:41977 Y Y ECO:0000311 UniProtKB AAP 11/28/2012 147 2000000085 Mike P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 22 uM for menadione 22 uM menadione CHEBI:28869 Y Y ECO:0000311 UniProtKB AAP 11/28/2012 147 2000000086 Mike P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 247 uM for NADPH 247 uM NADPH CHEBI:16474 Y Y ECO:0000311 UniProtKB AAP 11/28/2012 147 2000000087 Mike P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 309 uM for prostaglandin E2 309 uM prostaglandin E2 CHEBI:15551 Y Y ECO:0000311 UniProtKB AAP 11/28/2012 147 2000000088 Mike P16152 873 CBR1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 30 uM for S-nitrosoglutathione 30 uM S-nitrosoglutathione CHEBI:50091 Y Y ECO:0000006 PubMed:18826943 PubMed:17344335 UniProtKB AAP 11/28/2012 147 2000000089 Mike O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 25 uM for menadione (PubMed:15537833) 25 uM menadione CHEBI:28869 Y Y ECO:0000006 PubMed:15537833 UniProtKB AAP 11/28/2012 115 2000000090 Mike O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 43 uM for menadione (PubMed:18493841) 43 uM menadione CHEBI:28869 Y Y ECO:0000006 PubMed:18493841 UniProtKB AAP 11/28/2012 115 2000000091 Mike O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 90 uM for NADPH (PubMed:15537833) 90 uM NADPH CHEBI:16474 Y Y ECO:0000006 PubMed:15537833 UniProtKB AAP 11/28/2012 115 2000000092 Mike O75828 874 CBR3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 38 uM for NADPH (PubMed:18493841) 38 uM NADPH CHEBI:16474 Y Y ECO:0000006 PubMed:18493841 UniProtKB AAP 11/28/2012 115 2000000093 Mike P05177 1544 CYP1A2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 71 uM for 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine 71 uM 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Y Y ECO:0000311 UniProtKB request from ChEBI:2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine AAP 11/28/2012 140 2000000094 Mike P05177 1544 CYP1A2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 26 uM for 2-amino-2,4-dimethylimidazo[4,5-f]quinoline 26 uM 2-amino-2,4-dimethylimidazo[4,5-f]quinoline Y Y ECO:0000311 UniProtKB request from ChEBI:2-amino-2,4-dimethylimidazo[4,5-f]quinoline AAP 11/28/2012 140 2000000095 Mike P05177 1544 CYP1A2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 21 uM for 2-amino-3-methylimidazo[4,5-f]quinoline 21 uM 2-amino-3-methylimidazo[4,5-f]quinoline Y Y ECO:0000311 UniProtKB request from ChEBI: 2-amino-3-methylimidazo[4,5-f]quinoline AAP 11/28/2012 140 2000000096 Mike P05177 1544 CYP1A2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 27 uM for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline 27 uM 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline Y Y ECO:0000311 UniProtKB request from ChEBI:2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline AAP 11/28/2012 140 2000000097 Mike/Rose P05177 1544 CYP1A2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 4 uM for 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole 4 uM 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole Y Y ECO:0000006 PubMed:14725854 UniProtKB request from ChEBI: 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole; PUBCHEMcid:49971 AAP 11/28/2012 140 2000000098 Mike P05177 1544 CYP1A2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 25 uM for phenacetin 25 uM phenacetin CHEBI:8050 Y Y ECO:0000311 UniProtKB AAP 11/28/2012 140 2000000099 Katie Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 6.0 uM for 17-beta-estradiol 6 uM 17beta-estradiol CHEBI:16469 Y Y ECO:0000006 PubMed:10426814 UniProtKB Curated by Faith AAP 11/28/2012 148 2000000100 Katie Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 14.95 nmol/min/mg enzyme for 17-beta-estradiol 4-hydroxylation 14.95 nmol/min/mg 17beta-estradiol CHEBI:16469 Y Y ECO:0000311 UniProtKB Curated by Faith 4-hydroxylation AAP 11/28/2012 148 2000000101 Katie Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 6.9 nmol/min/mg enzyme for 17-beta-estradiol 2-hydroxylation 6.9 nmol/min/mg 17beta-estradiol CHEBI:16469 Y Y ECO:0000311 UniProtKB Curated by Faith 2-hydroxylation AAP 11/28/2012 148 2000000102 Katie Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 24.0 uM for progesterone 24 uM progesterone CHEBI:17026 Y Y ECO:0000311 UniProtKB Curated by Faith AAP 11/28/2012 148 2000000103 Katie Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 9.86 nmol/min/mg enzyme for progesterone 6-beta-hydroxylation 9.86 nmol/min/mg progesterone CHEBI:17026 Y Y ECO:0000311 UniProtKB Curated by Faith AAP 11/28/2012 148 2000000104 Katie Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 37.80 nmol/min/mg enzyme for progesterone 16-alpha-hydroxylation 37.8 nmol/min/mg progesterone CHEBI:17026 Y Y ECO:0000311 UniProtKB Curated by Faith AAP 11/28/2012 148 2000000105 Katie/Faith Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 17.0 uM for testosterone 17 uM testosterone CHEBI:17347 Y Y ECO:0000311 UniProtKB Curated by Faith AAP 11/28/2012 148 2000000106 Katie/Faith Q16678 1545 CYP1B1 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 36.16 nmol/min/mg enzyme for testosterone 6-beta-hydroxylation 36.16 nmol/min/mg testosterone CHEBI:17347 Y Y ECO:0000311 UniProtKB Curated by Faith AAP 11/28/2012 148 2000000107 Rose P20813 1555 CYP2B6 Homo sapiens 9606 Comment/biophysicochemical properties/KM 360 uM for 1,4-cineole 360 uM cineole CHEBI:23243 Y Y ECO:0000006 PubMed:11695850 UniProtKB 1,4-cineole not in ChEBI, send request. AAP 11/28/2012 143 2000000108 Rose P20813 1555 CYP2B6 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 3.4 nmol/min/nmol enzyme toward 2-exo-hydroxy-1,4-cineole 3.4 nmol/min/nmol cineole CHEBI:23243 Y Y ECO:0000311 UniProtKB 2-exo-hydroxy-1,4-cineole not in ChEBI,send request. AAP 11/28/2012 143 2000000109 Faith Q7Z449 113612 CYP2U1 Homo sapiens 9606 Comment/biophysicochemical properties/KM 2.7 uM for arachidonic acid 2.7 uM arachidonic acid CHEBI:15843 Y Y ECO:0000311 UniProtKB AAP 11/28/2012 94 2000000110 Faith Q5TCH4 284541 CYP4A22 Homo sapiens 9606 Comment/biophysicochemical properties/KM 56.7 uM for laurate 56.7 uM laurate CHEBI:18262 Y Y ECO:0000006 PubMed:10860550 UniProtKB AAP 11/28/2012 75 2000000111 Faith Q5TCH4 284541 CYP4A22 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax Vmax:15.2 umol/min/umol enzyme. 15.2 umol/min/umol laurate CHEBI:18262 Y Y ECO:0000006 PubMed:10860550 UniProtKB AAP 11/28/2012 75 2000000112 Faith P98187 11283 CYP4F8 Homo sapiens 9606 Comment/biophysicochemical properties/KM 7 uM for 9-alpha,11-alpha-epoxymethano-PGH2 (U-44069) 7 uM prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 PubMed:10791960 UniProtKB Substrate used is a stable analog of PGH2. Request: 9-alpha,11-alpha-epoxymethano-PGH2 (U-44069) AAP 2/6/2013 106 2000000113 Faith P98187 11283 CYP4F8 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax The Vmax of the reaction with U-44069 as substrate is 260 pmol/min/pmol enzyme. 260 pmol/min/pmol prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 PubMed:10791960 UniProtKB Substrate used is a stable analog of PGH2. Request: 9-alpha,11-alpha-epoxymethano-PGH2 (U-44069) AAP 2/6/2013 106 2000000114 Faith P98187 11283 CYP4F8 Homo sapiens 9606 Comment/biophysicochemical properties/KM 40 uM for 6,9-alpha-methylene-PGI2 40 uM prostaglandin I2 CHEBI:15552 Y Y ECO:0000006 PubMed:15789615 UniProtKB Substrate used is a stable analog of PGI2. Request: 6,9-alpha-methylene-PGI2 AAP 2/6/2013 106 2000000115 Rose P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 1.1 mM for p-nitrophenyl phosphate 1.1 mM 4-nitrophenyl phosphate CHEBI:17440 Y Y ECO:0000311 UniProtKB AAP 1/9/2013 131 2000000116 Rose P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 5.8 nmol/min/mg enzyme with p-nitrophenyl phosphate 5.8 nmol/min/mg 4-nitrophenyl phosphate CHEBI:17440 Y Y ECO:0000311 UniProtKB AAP 1/9/2013 131 2000000117 Rose P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 21 uM for threo-9,10-phosphonooxy-hydroxy-octadecanoic acid 21 uM threo-9,10-phosphonooxy-hydroxy-octadecanoic acid Y N ECO:0000006 PubMed:12574508 PubMed:12574510 PubMed:15196990 UniProtKB request from ChEBI: threo-9,10-phosphonooxy-hydroxy-octadecanoic acid AAP 1/9/2013 131 2000000118 Rose P34913 2053 EPHX2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 338 nmol/min/mg enzyme with threo-9,10-phosphonooxy-hydroxy-octadecanoic acid 338 nmol/min/mg Y Y ECO:0000311 UniProtKB AAP 1/9/2013 131 2000000119 Katie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM 38 uM for NAD 38 uM NAD(+) CHEBI:15846 Y Y ECO:0000006 PubMed:16828555 UniProtKB Curated by Faith. I put NAD+ instead of NAD because that is how substrate is listed in the ref AAP 2/6/2013 135 2000000120 Katie P15428 3248 HPGD Homo sapiens 9606 Comment/biophysicochemical properties/KM 3.4 uM for prostaglandin E2 3.4 uM prostaglandin E2 CHEBI:15551 Y Y ECO:0000006 PubMed:16828555 UniProtKB Curated by Faith AAP 2/6/2013 135 2000000121 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 5.1 umol/min/mg enzyme with 1-chloro-2,4-dinitrobenzene as substrate 5.1 umol/min/mg 1-chloro-2,4-dinitrobenzene CHEBI:34718 Y Y ECO:0000311 UniProtKB AAP 2/6/2013 124 2000000122 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 44.3 umol/min/mg enzyme with 1-fluoro-2,4-dinitrobenzene as substrate 44.3 umol/min/mg 1-fluoro-2,4-dinitrobenzene CHEBI:53049 Y Y ECO:0000311 UniProtKB AAP 2/6/2013 124 2000000123 Mike/Rose O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 6.8 umol/min/mg enzyme with allyl isothiocyanate as substrate 6.8 umol/min/mg allyl isothiocyanate Y Y ECO:0000311 UniProtKB request from ChEBI: allyl isothiocyanate; PUBCHEMcid:5971 AAP 2/6/2013 124 2000000124 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 6.3 umol/min/mg enzyme with benzyl isothiocyanate as substrate 6.3 umol/min/mg benzyl isothiocyanate CHEBI:17484 Y Y ECO:0000311 UniProtKB AAP 2/6/2013 124 2000000125 Mike/Rose O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.05 umol/min/mg enzyme with cumene hydroperoxide as substrate 0.05 umol/min/mg cumene hydroperoxide Y Y ECO:0000311 UniProtKB request from ChEBI: cumene hydroperoxide; PUBCHEMcid:6629 AAP 2/6/2013 124 2000000126 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 8.6 umol/min/mg enzyme with 1-bromo-2,4-dinitrobenzene as substrate 8.6 umol/min/mg dinitrobenzene CHEBI:51396 Y Y ECO:0000311 UniProtKB request from ChEBI AAP 2/6/2013 124 2000000127 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 10.7 umol/min/mg enzyme with 1-iodo-2,4-dinitrobenzene as substrate 10.7 umol/min/mg dinitrobenzene CHEBI:51396 Y Y ECO:0000311 UniProtKB request from ChEBI AAP 2/6/2013 124 2000000128 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/KM 8 mM for glutathione for the glutathione-conjugating activity 8 mM glutathione CHEBI:16856 Y Y ECO:0000006 PubMed:11672424 PubMed:12627223 PubMed:15113825 UniProtKB AAP 2/6/2013 124 2000000129 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.6 mM for glutathione for the prostaglandin D synthase activity in the presence of EDTA 0.6 mM glutathione CHEBI:16856 Y Y ECO:0000311 UniProtKB AAP 2/6/2013 124 2000000130 Mike O60760 27306 HPGDS Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.14 mM for glutathione for the prostaglandin D synthase activity in the presence of magnesium ions 0.14 mM glutathione CHEBI:16856 Y Y ECO:0000311 UniProtKB AAP 2/6/2013 124 2000000131 Mike P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.4 mM for HDL(2) 0.4 mM high-density lipoprotein CHEBI:39025 Y Y ECO:0000311 UniProtKB request from ChEBI AAP 11/28/2012 141 2000000132 Mike P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.10 mM for HDL(3) 0.10 mM high-density lipoprotein CHEBI:39025 Y Y ECO:0000311 UniProtKB request from ChEBI AAP 11/28/2012 141 2000000133 Mike P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 8.3 mmol/min/mg enzyme with LDL as substrate 8.3 mmol/min/mg high-density lipoprotein CHEBI:39025 Y Y ECO:0000311 UniProtKB AAP 11/28/2012 141 2000000134 Mike P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.58 mmol/min/mg enzyme with HDL(2) as substrate 0.58 mmol/min/mg high-density lipoprotein CHEBI:39025 Y Y ECO:0000311 UniProtKB request from ChEBI AAP 11/28/2012 141 2000000135 Mike P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2.0 mmol/min/mg enzyme with HDL(3) as substrate 2.0 mmol/min/mg high-density lipoprotein CHEBI:39025 Y Y ECO:0000311 UniProtKB request from ChEBI AAP 11/28/2012 141 2000000136 Mike P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM 0.97 mM for LDL 0.97 mM low-density lipoprotein CHEBI:39026 Y Y ECO:0000006 PubMed:10329423 UniProtKB AAP 11/28/2012 141 2000000137 Mike P04180 3931 LCAT Homo sapiens 9606 Comment/biophysicochemical properties/KM Affinity for LDL is 2.3 to 4-fold lower than for HDL. Relative reactivities are 16% for HDL(3), 1.3% for HDL(2) and 6.5% for LDL. Y N ECO:0000311 UniProtKB AAP 11/28/2012 141 2000000138 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 6247 nmol/min/mg enzyme with arachidonoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates 6247 nmol/min/mg arachidonoyl-CoA CHEBI:15514 lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB Two substrates are required. The second substrate is given in Column N. LPC16:0 covers a connection of palmitoyl at either 1 or 2 in the glycero moiety. AAP 1/9/2013 82 2000000139 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 18148 nmol/min/mg enzyme with linoleoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates 18148 nmol/min/mg linoleoyl-CoA CHEBI:15530 lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB Two substrates are required. The second substrate is given in Column N. LPC16:0 covers a connection of palmitoyl at either 1 or 2 in the glycero moiety. AAP 1/9/2013 82 2000000140 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 4698 nmol/min/mg enzyme with oleoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates 4698 nmol/min/mg oleoyl-CoA CHEBI:15534 lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB Two substrates are required. The second substrate is given in Column N. LPC16:0 covers a connection of palmitoyl at either 1 or 2 in the glycero moiety. AAP 1/9/2013 82 2000000141 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1782 nmol/min/mg enzyme with palmitoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates 1782 nmol/min/mg palmitoyl-CoA CHEBI:15525 lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB Two substrates are required. The second substrate is given in Column N. LPC16:0 covers a connection of palmitoyl at either 1 or 2 in the glycero moiety. AAP 1/9/2013 82 2000000142 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 996 nmol/min/mg enzyme with stearoyl-CoA and 1-palmitoyl-lysophosphatidylcholine as substrates 996 nmol/min/mg stearoyl-CoA CHEBI:15541 lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB Two substrates are required. The second substrate is given in Column N. LPC16:0 covers a connection of palmitoyl at either 1 or 2 in the glycero moiety. AAP 1/9/2013 82 2000000143 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 71.56 uM for arachidonoyl-CoA 71.56 uM arachidonoyl-CoA CHEBI:15514 Y Y ECO:0000311 UniProtKB AAP 1/9/2013 82 2000000144 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 201.4 uM for linoleoyl-CoA 201.4 uM linoleoyl-CoA CHEBI:15530 Y Y ECO:0000311 UniProtKB AAP 1/9/2013 82 2000000145 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 72.19 uM for 1-palmitoyl-lysophosphatidylcholine 72.19 uM lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB LPC16:0 covers a connection of palmitoyl at either 1 or 2 in the glycero moiety. AAP 1/9/2013 82 2000000146 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 72.68 uM for oleoyl-CoA 72.68 uM oleoyl-CoA CHEBI:15534 Y Y ECO:0000311 UniProtKB AAP 1/9/2013 82 2000000147 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 41.29 uM for palmitoyl-CoA 41.29 uM palmitoyl-CoA CHEBI:15525 Y Y ECO:0000006 PubMed:18195019 UniProtKB AAP 1/9/2013 82 2000000148 Faith Q6P1A2 10162 LPCAT3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 36.65 uM for stearoyl-CoA 36.65 uM stearoyl-CoA CHEBI:15541 Y Y ECO:0000311 UniProtKB AAP 1/9/2013 82 2000000149 Rose P47712 5321 PLA2G4A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2.7 umol/min/mg enzyme for the phospholipase A2 reaction 2.7 umol/min/mg Y Y ECO:0000006 PubMed:8083230 UniProtKB AAP 11/28/2012 140 2000000150 Rose P47712 5321 PLA2G4A Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 4.6 umol/min/mg enzyme for the lysophosphatase reaction 4.6 umol/min/mg Y Y ECO:0000311 UniProtKB AAP 11/28/2012 140 2000000151 Mike P0C869 100137049;8681 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2.1 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PC as substrate (isoform 5) 2.1 nmol/min/ug 1-O-palmitoyl-2-O-arachidonoyl-sn-glycero-3-phosphocholine CHEBI:60378 Y Y ECO:0000311 UniProtKB isoform 5 AAP 11/28/2012 45 2000000152 Mike P0C869 100137049;8681 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 3.6 pmol/min/ug enzyme with cAMP as substrate (isoform 4) 3.6 pmol/min/ug 3',5'-cyclic AMP CHEBI:17489 Y Y ECO:0000311 UniProtKB AAP 11/28/2012 45 2000000153 Mike P0C869 100137049;8681 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.6 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 5) 0.6 nmol/min/ug dialkylglycerophosphoethanolamine CHEBI:37814 Y Y ECO:0000311 UniProtKB request from ChEBI: 1-16:0-2-[14C]20:4-PE AAP 11/28/2012 45 2000000154 Mike P0C869 100137049;8681 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.8 nmol/min/ug enzyme with 1-16:0-2-[14C]20:4-PE as substrate (isoform 3) 0.8 nmol/min/ug dialkylglycerophosphoethanolamine CHEBI:37814 Y Y ECO:0000311 UniProtKB request from ChEBI: 1-16:0-2-[14C]20:4-PE AAP 11/28/2012 45 2000000155 Mike P0C869 100137049;8681 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 0.3 nmol/min/ug enzyme with 1-16:0-2-[14C]18:2-PE as substrate (isoform 3) 0.3 nmol/min/ug dialkylglycerophosphoethanolamine CHEBI:37814 Y Y ECO:0000311 UniProtKB request from ChEBI: 1-16:0-2-[14C]18:2-PE AAP 11/28/2012 45 2000000156 Mike P0C869 100137049;8681 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 140 nmol/min/ug enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 5) 140 nmol/min/ug lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB request from ChEBI: 1-[14C]16:0-2-lyso-PC AAP 11/28/2012 45 2000000157 Mike P0C869 100137049;8681 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 1.6 nmol/min/ug enzyme with 1-[14C]16:0-2-lyso-PC as substrate (isoform 3) 1.6 nmol/min/ug lysophosphatidylcholine 16:0 CHEBI:64563 Y Y ECO:0000311 UniProtKB request from ChEBI: 1-[14C]16:0-2-lyso-PC AAP 11/28/2012 45 2000000158 Mike P0C869 100137049;8681 PLA2G4B Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 7.9 pmol/min/mg enzyme (isoform 5) 7.9 pmol/min/mg Y Y ECO:0000006 PubMed:10085124 UniProtKB substrate unclear AAP 11/28/2012 45 2000000159 Faith Q9UP65 8605 PLA2G4C Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 218 pmol/min/mg enzyme 218 pmol/min/mg 1-O-palmitoyl-2-O-arachidonoyl-sn-glycero-3-phosphocholine CHEBI:60378 Y Y ECO:0000006 PubMed:10085124 UniProtKB Curated by Faith. Article states that enzyme assay carried out as previously in two cited articles. One article used 1-palmitoyl-2-[14C]arachidonoyl-sn-glycero-3-phosphocholine and other [14C]arachidonoyl phosphatidylcholine. I could note phosphatidylcholine, but there are more specific options (diacylPC or specificacylPC AAP 11/28/2012 93 2000000160 Faith Q15185 10728 PTGES3 Homo sapiens 9606 Comment/biophysicochemical properties/KM 14 uM for PGH2 14 uM prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 PubMed:10922363 UniProtKB AAP 2/6/2013 125 2000000161 Faith Q15185 10728 PTGES3 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 190 nmol/min/mg enzyme toward PGH2 190 nmol/min/mg prostaglandin H2 CHEBI:15554 Y Y ECO:0000006 PubMed:10922363 UniProtKB AAP 2/6/2013 125 2000000162 Rose P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 16.2 uM for arachidonate (in absence of sodium nitroprusside NO donor) 16.2 uM arachidonate CHEBI:32395 Y Y ECO:0000006 PubMed:16373578 UniProtKB AAP 2/6/2013 143 2000000163 Rose P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/KM 17.0 uM for arachidonate (in presence of sodium nitroprusside NO donor) 17 uM arachidonate CHEBI:32395 Y Y ECO:0000311 UniProtKB AAP 2/6/2013 143 2000000164 Rose P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 81.3 nmol/min/mg enzyme (in absence of sodium nitroprusside NO donor) 81.3 nmol/min/mg Y Y ECO:0000311 UniProtKB AAP 2/6/2013 143 2000000165 Rose P35354 5743 PTGS2 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 132 nmol/min/mg enzyme (in absence of sodium nitroprusside NO donor) 132 nmol/min/mg Y Y ECO:0000311 UniProtKB AAP 2/6/2013 143 2000000166 Faith P53816 11145 PLA2G16 Homo sapiens 9606 Comment/biophysicochemical properties/KM 300 uM for dipalmitoyl-PC 300 uM 1,2-di-O-palmitoyl-sn-glycero-3-phosphocholine CHEBI:40265 Y Y ECO:0000006 PubMed:19615464 UniProtKB AAP 5/29/2013 109 2000000167 Faith P53816 11145 PLA2G16 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 2.57 umol/min/mg enzyme with dipalmitoyl-PC as substrate 2.57 umol/min/mg 1,2-di-O-palmitoyl-sn-glycero-3-phosphocholine CHEBI:40265 Y Y PubMed:19615464 UniProtKB AAP 5/29/2013 109 2000000168 Faith P53816 11145 PLA2G16 Homo sapiens 9606 Comment/biophysicochemical properties/Vmax 267 nmol/min/mg enzyme with dipalmitoyl-PE as substrate 267 nmol/min/mg 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine CHEBI:73127 Y Y UniProtKB AAP 5/29/2013 109 2000000169