Arachidonic Acid Pathway v14

  • Posted on: 22 August 2016
  • By: Sven
PTGS1 PTGS2 COX1 COX2 Arachidonic acidall-cis-5,8,11,14-Eicosatetraenoic acid = other eicosanoids = 15(R)-HETE 15R M = metabolites HETEs DHETs Epoxides(EETs) CyP450 HepoxilinsandTrioxilins 12(S)-HETE GPXs 12(S)-HpETE 12-Lipoxygenase (12-LO) ALOX12B M Lipoxins A4 & B4 (LXA 4 & LXB 4 ) 5-LO 15(S)-HETE GPXs 15(S)-HpETE 15-Lipoxygenase Leukotrienetransporters Leukotrienereceptors M Leukotrienes M Leukotriene A4 (LTA 4 ) LOX5 regulators 5-Lipoxygenase (5-LO) 5-HETEs acetylated COX2 15R ThromboxaneA2 receptor M Thromboxane A2 (TxA 2 ) Prostaglandinreceptors M Prostaglandins Prostacyclinreceptor M Prostacyclin (PGI 2 ) Prostaglandin H2 (PGH 2 ) COX2 inhibitors(e.g. celecoxib) Non-selective NSAIDs (e.g. aspirin, ibuprofen, naproxen) COX2 COX1 Central lipid andphospholipid metabolism diet e x t e n s i o n o f l i n o l e i c a c i d arachidonic acid remodeling addition of CoA c l e a v a g e o f p h o s p h o l i p i d s